SIMILAR PATTERNS OF AMINO ACIDS FOR 4TWP_B_AXIB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		9 VAL A 588
ALA A 606
LYS A 608
MET A 657
GLY A 660
ASN A 729
LEU A 731
ALA A 741
ASP A 742
 None
 0.65A 4twpB-1lufA:
32.6		 4twpB-1lufA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 267
TYR A 272
VAL A 275
ALA A 288
LYS A 290
PHE A 336
MET A 337
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.80A 4twpB-1opkA:
38.4		 4twpB-1opkA:
98.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 267
VAL A 275
ALA A 288
LYS A 290
PHE A 336
MET A 337
GLY A 340
ASN A 387
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.51A 4twpB-1opkA:
38.4		 4twpB-1opkA:
98.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  26
VAL A  34
ALA A  47
LYS A  49
PHE A 100
GLY A 104
ASN A 153
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
None
 0.70A 4twpB-2bujA:
25.1		 4twpB-2bujA:
22.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
VAL X  25
ALA X  37
LYS X  39
MET X  85
GLY X  88
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.53A 4twpB-2dq7X:
36.7		 4twpB-2dq7X:
46.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
VAL X  25
ALA X  37
MET X  85
GLY X  88
ASN X 135
LEU X 137
ALA X 147
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-3.5A)
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.41A 4twpB-2dq7X:
36.7		 4twpB-2dq7X:
46.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 162
VAL A 170
ALA A 184
LYS A 186
ASN A 288
LEU A 290
ALA A 319
ASP A 320
 None
 0.71A 4twpB-2eu9A:
23.8		 4twpB-2eu9A:
25.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
H8H  A 534 (-4.2A)
 0.74A 4twpB-2h8hA:
30.9		 4twpB-2h8hA:
33.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
PHE A 340
MET A 341
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.97A 4twpB-2hckA:
30.8		 4twpB-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
PHE A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.75A 4twpB-2hckA:
30.8		 4twpB-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 251
VAL A 259
ALA A 271
LYS A 273
PHE A 318
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.81A 4twpB-2hk5A:
31.6		 4twpB-2hk5A:
48.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
VAL A 256
ALA A 269
LYS A 271
PHE A 317
MET A 318
GLY A 321
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.3A)
None
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.59A 4twpB-2hz0A:
36.2		 4twpB-2hz0A:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 248
VAL A 256
ALA A 269
PHE A 317
MET A 318
GLY A 321
ASN A 368
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.3A)
None
None
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.62A 4twpB-2hz0A:
36.2		 4twpB-2hz0A:
99.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
LYS A 273
MET A 319
GLY A 322
LEU A 371
ALA A 381
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.82A 4twpB-2og8A:
26.0		 4twpB-2og8A:
47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.80A 4twpB-2og8A:
26.0		 4twpB-2og8A:
47.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		8 LEU A  25
VAL A  33
ALA A  46
LYS A  48
MET A 106
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.65A 4twpB-2phkA:
19.5		 4twpB-2phkA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		8 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
ASN A 154
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.52A 4twpB-2phkA:
19.5		 4twpB-2phkA:
28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  90
ALA A 103
LYS A 105
MET A 156
GLY A 159
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
None
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.90A 4twpB-2v55A:
21.0		 4twpB-2v55A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  90
ALA A 103
MET A 156
GLY A 159
ASN A 203
LEU A 205
ALA A 215
ASP A 216
 None
ANP  A1480 ( 3.9A)
None
None
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.80A 4twpB-2v55A:
21.0		 4twpB-2v55A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  34
ALA A  47
LYS A  49
GLY A 101
ASN A 145
LEU A 147
ALA A 157
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
J60  A1294 ( 4.6A)
 0.76A 4twpB-2xikA:
21.4		 4twpB-2xikA:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  68
VAL A  76
ALA A  92
PHE A 143
GLY A 147
ASN A 192
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.48A 4twpB-2z7rA:
22.5		 4twpB-2z7rA:
25.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 253
VAL A 261
ALA A 273
PHE A 321
MET A 322
GLY A 325
ASN A 372
LEU A 374
ALA A 384
 None
 0.84A 4twpB-2zv7A:
33.9		 4twpB-2zv7A:
46.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 VAL A 261
ALA A 273
PHE A 321
MET A 322
GLY A 325
ASN A 372
LEU A 374
ALA A 384
ASP A 385
 None
 0.76A 4twpB-2zv7A:
33.9		 4twpB-2zv7A:
46.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
ASN A 631
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
 0.54A 4twpB-3b2tA:
34.5		 4twpB-3b2tA:
41.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLY A 567
ASN A 628
LEU A 630
ALA A 640
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-4.5A)
 0.99A 4twpB-3c4fA:
32.4		 4twpB-3c4fA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 647
ALA A 663
LYS A 665
PHE A 713
MET A 714
GLY A 717
ASN A 763
LEU A 765
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
None
None
IHZ  A1001 ( 3.9A)
None
IHZ  A1001 (-4.6A)
 0.77A 4twpB-3dkoA:
30.8		 4twpB-3dkoA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 158
ALA A 169
LYS A 171
PHE A 222
GLY A 226
ASN A 273
LEU A 275
ASP A 294
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.8A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-4.5A)
VIN  A6331 (-4.0A)
 0.70A 4twpB-3dtcA:
27.3		 4twpB-3dtcA:
35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLY A 915
ASN A1027
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
None
None
None
 0.76A 4twpB-3hngA:
30.9		 4twpB-3hngA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 VAL A  37
ALA A  49
LYS A  51
PHE A 100
MET A 101
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
ADP  A 314 ( 4.3A)
None
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.84A 4twpB-3nizA:
25.0		 4twpB-3nizA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 VAL A  37
ALA A  49
PHE A 100
MET A 101
ASN A 149
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 ( 4.3A)
None
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.63A 4twpB-3nizA:
25.0		 4twpB-3nizA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
MET A 266
GLY A 269
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.67A 4twpB-3nyoA:
24.5		 4twpB-3nyoA:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
ASN A 850
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.70A 4twpB-3pp0A:
32.7		 4twpB-3pp0A:
33.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
VAL A  71
ALA A  84
LYS A  86
PHE A 146
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.68A 4twpB-3q5iA:
22.9		 4twpB-3q5iA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
VAL A  71
ALA A  84
PHE A 146
GLY A 150
ASN A 195
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.8A)
None
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.68A 4twpB-3q5iA:
22.9		 4twpB-3q5iA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLY A 567
ASN A 628
LEU A 630
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.7A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.73A 4twpB-3tt0A:
31.1		 4twpB-3tt0A:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
LYS A 514
GLY A 567
ASN A 628
LEU A 630
ALA A 640
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.7A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
07J  A   1 (-4.7A)
 0.89A 4twpB-3tt0A:
31.1		 4twpB-3tt0A:
34.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 361
VAL A 369
ALA A 382
LYS A 384
PHE A 435
GLY A 439
LEU A 486
ALA A 496
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
 0.75A 4twpB-3txoA:
15.3		 4twpB-3txoA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 361
VAL A 369
ALA A 382
PHE A 435
GLY A 439
ASN A 484
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.75A 4twpB-3txoA:
15.3		 4twpB-3txoA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 544
VAL A 552
ALA A 570
LYS A 572
MET A 620
GLY A 623
ASN A 684
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.97A 4twpB-3v5qA:
31.2		 4twpB-3v5qA:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
 0.67A 4twpB-3vidA:
30.2		 4twpB-3vidA:
34.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 139
VAL A 147
ALA A 160
LYS A 162
GLY A 216
ASN A 261
LEU A 263
ALA A 273
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
N13  A 501 (-3.5A)
None
N13  A 501 (-4.5A)
N13  A 501 ( 3.8A)
 0.83A 4twpB-3w18A:
22.4		 4twpB-3w18A:
27.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
GOL  A1210 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.78A 4twpB-3wzdA:
32.2		 4twpB-3wzdA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1951
VAL A1959
ALA A1978
LYS A1980
MET A2029
GLY A2032
LEU A2086
ASP A2102
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
 0.87A 4twpB-3zbfA:
33.7		 4twpB-3zbfA:
39.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A1959
ALA A1978
LYS A1980
MET A2029
GLY A2032
ASN A2084
LEU A2086
ASP A2102
 None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
None
VGH  A3000 (-4.3A)
None
 0.80A 4twpB-3zbfA:
33.7		 4twpB-3zbfA:
39.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 633
ALA A 649
PHE A 699
MET A 700
GLY A 703
ASN A 749
LEU A 751
ASP A 762
 None
 0.59A 4twpB-3zfxA:
34.4		 4twpB-3zfxA:
40.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  83
VAL A  91
ALA A 104
LYS A 106
GLY A 160
ASN A 205
LEU A 207
ALA A 217
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-4.6A)
VX6  A 500 ( 4.2A)
 1.16A 4twpB-4af3A:
21.0		 4twpB-4af3A:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 560
VAL A 568
ALA A 586
LYS A 588
GLY A 639
ASN A 697
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.87A 4twpB-4at3A:
32.0		 4twpB-4at3A:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 560
VAL A 568
ALA A 586
MET A 636
GLY A 639
ASN A 697
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
None
 0.66A 4twpB-4at3A:
32.0		 4twpB-4at3A:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 105
ALA A 121
LYS A 123
PHE A 171
MET A 172
GLY A 175
ASN A 221
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.4A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.72A 4twpB-4aw5A:
33.3		 4twpB-4aw5A:
39.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  42
VAL A  50
ALA A  63
LYS A  65
PHE A 112
GLY A 116
ASN A 162
LEU A 164
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.98A 4twpB-4bc6A:
23.1		 4twpB-4bc6A:
30.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
VAL A  30
ALA A  43
GLY A  99
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.74A 4twpB-4cfhA:
25.7		 4twpB-4cfhA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASN A 144
LEU A 146
ALA A 156
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.81A 4twpB-4cfhA:
25.7		 4twpB-4cfhA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 653
LYS A 655
MET A 704
ASN A 771
LEU A 773
ALA A 783
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
None
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
 0.70A 4twpB-4ckrA:
30.2		 4twpB-4ckrA:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
GLY A 743
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.54A 4twpB-4crsA:
18.9		 4twpB-4crsA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
PHE A  88
GLY A  92
ASN A 140
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
BX7  A 401 ( 3.7A)
 0.79A 4twpB-4eutA:
14.1		 4twpB-4eutA:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 514
VAL A 522
ALA A 538
LYS A 540
PHE A 595
MET A 596
GLY A 599
ALA A 662
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.5A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
 0.82A 4twpB-4feqA:
22.9		 4twpB-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 514
VAL A 522
ALA A 538
PHE A 595
GLY A 599
ASN A 650
ALA A 662
ASP A 663
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
0T8  A 901 ( 3.8A)
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
 0.80A 4twpB-4feqA:
22.9		 4twpB-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 514
VAL A 522
ALA A 538
PHE A 595
MET A 596
GLY A 599
ALA A 662
ASP A 663
 0T8  A 901 (-3.6A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
 0.78A 4twpB-4feqA:
22.9		 4twpB-4feqA:
40.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
VAL A1130
ALA A1148
MET A1199
GLY A1202
ASN A1254
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.79A 4twpB-4fodA:
31.4		 4twpB-4fodA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLY A 908
ASN A 954
LEU A 956
ALA A 966
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
19S  A1201 ( 3.8A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 0.56A 4twpB-4hviA:
33.7		 4twpB-4hviA:
35.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
PHE A  88
GLY A  92
ASN A 140
ASP A 157
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
None
None
 0.82A 4twpB-4jlcA:
18.6		 4twpB-4jlcA:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.92A 4twpB-4k11A:
30.9		 4twpB-4k11A:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.73A 4twpB-4k11A:
30.9		 4twpB-4k11A:
33.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
VAL A 486
ALA A 506
GLY A 561
ASN A 622
LEU A 624
ALA A 634
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.6A)
MG  A 802 ( 2.4A)
ACP  A 801 (-4.4A)
None
MG  A 802 ( 3.0A)
 0.55A 4twpB-4k33A:
29.5		 4twpB-4k33A:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.74A 4twpB-4lggA:
30.5		 4twpB-4lggA:
47.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLY A 128
ASN A 178
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
None
 0.63A 4twpB-4o38A:
21.5		 4twpB-4o38A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLY A 984
ASN A1028
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.5A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.72A 4twpB-4oliA:
30.8		 4twpB-4oliA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 627
VAL A 635
ALA A 648
GLY A 707
ASN A 751
LEU A 753
ALA A 763
ASP A 764
 None
 0.91A 4twpB-4otdA:
24.4		 4twpB-4otdA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  24
VAL A  32
ALA A  45
GLY A 101
ASN A 146
LEU A 148
ALA A 158
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.7A)
 0.81A 4twpB-4rewA:
25.5		 4twpB-4rewA:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 ALA A  35
LYS A  37
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
None
 0.62A 4twpB-4ueuA:
35.1		 4twpB-4ueuA:
66.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 LEU A  14
VAL A  22
ALA A  35
LYS A  37
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.74A 4twpB-4ueuA:
35.1		 4twpB-4ueuA:
66.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  40
VAL A  48
ALA A  61
PHE A 110
GLY A 114
ASN A 160
LEU A 162
ALA A 172
 6UI  A 700 ( 4.9A)
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
 1.02A 4twpB-4usfA:
18.3		 4twpB-4usfA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		9 LEU A 193
VAL A 201
ALA A 214
LYS A 216
MET A 267
GLY A 270
ASN A 319
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
None
 0.78A 4twpB-4wboA:
25.2		 4twpB-4wboA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  52
VAL A  60
ALA A  72
LYS A  74
PHE A 128
GLY A 132
ASN A 181
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.72A 4twpB-4wsqA:
24.9		 4twpB-4wsqA:
23.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLY A 556
ASN A 617
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.83A 4twpB-4xcuA:
31.9		 4twpB-4xcuA:
40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
VAL B 275
LYS B 290
PHE B 336
MET B 337
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.77A 4twpB-4xeyB:
33.1		 4twpB-4xeyB:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
VAL B 275
PHE B 336
MET B 337
GLY B 340
ASN B 387
LEU B 389
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.62A 4twpB-4xeyB:
33.1		 4twpB-4xeyB:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 VAL B 275
ALA B 288
LYS B 290
PHE B 336
MET B 337
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.76A 4twpB-4xeyB:
33.1		 4twpB-4xeyB:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 VAL B 275
ALA B 288
PHE B 336
MET B 337
GLY B 340
ASN B 387
LEU B 389
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.58A 4twpB-4xeyB:
33.1		 4twpB-4xeyB:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
VAL A 416
ALA A 428
LYS A 430
MET A 477
GLY A 480
ASN A 526
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-2.8A)
746  A 702 (-4.4A)
 0.74A 4twpB-4y93A:
31.3		 4twpB-4y93A:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLY A 567
ASN A 628
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.65A 4twpB-5a46A:
30.7		 4twpB-5a46A:
40.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		8 LEU A  99
VAL A 107
ALA A 120
LYS A 122
PHE A 172
GLY A 176
LEU A 223
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
5U5  A 401 (-4.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.68A 4twpB-5eykA:
16.1		 4twpB-5eykA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
VAL A  28
ALA A  41
GLY A  96
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
MG  A 302 ( 2.8A)
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.59A 4twpB-5hu3A:
26.2		 4twpB-5hu3A:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		9 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.87A 4twpB-5isoA:
25.6		 4twpB-5isoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
LYS A  45
PHE A  92
GLY A  96
ASN A 141
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 4twpB-5j5tA:
22.9		 4twpB-5j5tA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
PHE A  92
GLY A  96
ASN A 141
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.64A 4twpB-5j5tA:
22.9		 4twpB-5j5tA:
24.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 718
VAL A 726
ALA A 743
LYS A 745
MET A 793
GLY A 796
ASN A 842
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
None
6HJ  A1101 ( 4.8A)
 0.86A 4twpB-5j9zA:
31.6		 4twpB-5j9zA:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		8 VAL A 897
ALA A 909
PHE A 958
MET A 959
GLY A 962
ASN A1014
LEU A1016
ASP A1027
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.6A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
 0.51A 4twpB-5lpyA:
25.9		 4twpB-5lpyA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		8 VAL A 897
ALA A 909
PHE A 958
MET A 959
GLY A 962
ASN A1014
LEU A1016
ASP A1027
 ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
ADP  A1200 (-4.1A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-3.6A)
ADP  A1200 (-4.7A)
ADP  A1200 (-3.4A)
 0.45A 4twpB-5lpzA:
26.0		 4twpB-5lpzA:
28.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 593
VAL A 601
ALA A 617
PHE A 673
MET A 674
GLY A 677
ASN A 728
ALA A 740
ASP A 741
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.7A)
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
 0.63A 4twpB-5td2A:
16.9		 4twpB-5td2A:
44.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 542
VAL A 550
ALA A 565
LYS A 567
PHE A 622
MET A 623
GLY A 626
ALA A 689
ASP A 690
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
None
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
7YS  A9001 (-3.4A)
None
 0.79A 4twpB-5u6bA:
30.2		 4twpB-5u6bA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 542
VAL A 550
ALA A 565
PHE A 622
MET A 623
GLY A 626
ASN A 677
ALA A 689
ASP A 690
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
None
7YS  A9001 (-3.4A)
None
 0.76A 4twpB-5u6bA:
30.2		 4twpB-5u6bA:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A 106
ALA A 119
LYS A 121
MET A 172
GLY A 175
ASN A 219
LEU A 221
ALA A 231
ASP A 232
 None
 0.73A 4twpB-5u7qA:
21.4		 4twpB-5u7qA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 8 LEU A  24
VAL A  32
ALA A  45
MET A  98
GLY A 101
ASN A 151
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.63A 4twpB-5w5jA:
24.1		 4twpB-5w5jA:
27.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 8 LEU A 881
VAL A 889
ALA A 906
LYS A 908
PHE A 958
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.64A 4twpB-6c7yA:
32.3		 4twpB-6c7yA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 8 LEU A 881
VAL A 889
ALA A 906
PHE A 958
GLY A 962
ASN A1008
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
MG  A1202 ( 2.5A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.54A 4twpB-6c7yA:
32.3		 4twpB-6c7yA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 8 VAL A 179
ALA A 192
LYS A 194
GLY A 273
ASN A 317
LEU A 319
ALA A 329
ASP A 330
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 3.7A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
F6J  A 501 (-3.8A)
 0.67A 4twpB-6cmjA:
25.2		 4twpB-6cmjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 8 VAL A 200
ALA A 211
LYS A 213
MET A 265
GLY A 268
ASN A 316
LEU A 318
ASP A 329
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
None
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
 0.85A 4twpB-6f3dA:
25.7		 4twpB-6f3dA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 9 LEU U  20
VAL U  28
ALA U  42
LYS U  44
PHE U  93
GLY U  97
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 1.05A 4twpB-6fdyU:
24.9		 4twpB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 9 LEU U  20
VAL U  28
ALA U  42
PHE U  93
GLY U  97
ASN U 142
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.88A 4twpB-6fdyU:
24.9		 4twpB-6fdyU:
undetectable