SIMILAR PATTERNS OF AMINO ACIDS FOR 4TWD_F_377F402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		4 ALA A 386
ALA A 397
ALA A 395
ALA A 389
 None
 0.80A 4twdF-1a3xA:
0.0
4twdG-1a3xA:
0.0
4twdH-1a3xA:
0.0
4twdI-1a3xA:
0.0
4twdJ-1a3xA:
0.0		 4twdF-1a3xA:
20.71
4twdG-1a3xA:
20.71
4twdH-1a3xA:
20.71
4twdI-1a3xA:
20.71
4twdJ-1a3xA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens) 		PF00079
(Serpin) 		4 ALA A 117
ALA A 350
SER A  56
ALA A 352
 None
 0.79A 4twdF-1as4A:
0.9
4twdG-1as4A:
0.8
4twdH-1as4A:
0.5
4twdI-1as4A:
0.0
4twdJ-1as4A:
0.4		 4twdF-1as4A:
22.22
4twdG-1as4A:
22.22
4twdH-1as4A:
22.22
4twdI-1as4A:
22.22
4twdJ-1as4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbi AK.1 SERINE PROTEASE

(Bacillus sp.
Ak1) 		PF00082
(Peptidase_S8) 		4 ALA A 151
ALA A 123
ALA A 119
ALA A 117
 None
 0.78A 4twdF-1dbiA:
0.0
4twdG-1dbiA:
0.0
4twdH-1dbiA:
0.0
4twdI-1dbiA:
0.0
4twdJ-1dbiA:
0.0		 4twdF-1dbiA:
23.19
4twdG-1dbiA:
23.19
4twdH-1dbiA:
23.19
4twdI-1dbiA:
23.19
4twdJ-1dbiA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 SER A 400
ALA A 354
SER A 398
ALA A 173
 None
 0.79A 4twdF-1e5mA:
0.0
4twdG-1e5mA:
0.0
4twdH-1e5mA:
0.0
4twdI-1e5mA:
0.0
4twdJ-1e5mA:
0.0		 4twdF-1e5mA:
20.41
4twdG-1e5mA:
20.41
4twdH-1e5mA:
20.41
4twdI-1e5mA:
20.41
4twdJ-1e5mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		4 ALA A  41
ALA A  59
ALA A  61
ALA A 206
 None
 0.78A 4twdF-1ekqA:
0.0
4twdG-1ekqA:
0.0
4twdH-1ekqA:
0.0
4twdI-1ekqA:
0.0
4twdJ-1ekqA:
0.0		 4twdF-1ekqA:
19.28
4twdG-1ekqA:
19.28
4twdH-1ekqA:
19.28
4twdI-1ekqA:
19.28
4twdJ-1ekqA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq1 APOLIPOPHORIN-III

(Manduca sexta) 		PF07464
(ApoLp-III) 		4 ALA A  72
ALA A  64
ALA A  79
ALA A  75
 None
 0.71A 4twdF-1eq1A:
undetectable
4twdG-1eq1A:
1.0
4twdH-1eq1A:
2.1
4twdI-1eq1A:
undetectable
4twdJ-1eq1A:
undetectable		 4twdF-1eq1A:
20.79
4twdG-1eq1A:
20.79
4twdH-1eq1A:
20.79
4twdI-1eq1A:
20.79
4twdJ-1eq1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 ALA A 204
ALA A 337
ALA A 331
SER A 418
 None
 0.76A 4twdF-1gk2A:
0.0
4twdG-1gk2A:
0.1
4twdH-1gk2A:
0.8
4twdI-1gk2A:
0.0
4twdJ-1gk2A:
0.0		 4twdF-1gk2A:
20.48
4twdG-1gk2A:
20.48
4twdH-1gk2A:
20.48
4twdI-1gk2A:
20.48
4twdJ-1gk2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 ALA A 331
SER A 418
ALA A 204
ALA A 337
 None
 0.76A 4twdF-1gk2A:
0.0
4twdG-1gk2A:
0.1
4twdH-1gk2A:
0.8
4twdI-1gk2A:
0.0
4twdJ-1gk2A:
0.0		 4twdF-1gk2A:
20.48
4twdG-1gk2A:
20.48
4twdH-1gk2A:
20.48
4twdI-1gk2A:
20.48
4twdJ-1gk2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 SER A 393
ALA A 348
SER A 391
ALA A 167
 None
 0.73A 4twdF-1j3nA:
0.0
4twdG-1j3nA:
0.0
4twdH-1j3nA:
0.0
4twdI-1j3nA:
0.0
4twdJ-1j3nA:
0.0		 4twdF-1j3nA:
20.70
4twdG-1j3nA:
20.70
4twdH-1j3nA:
20.70
4twdI-1j3nA:
20.70
4twdJ-1j3nA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 ALA A 262
ALA A  67
ALA A 247
ALA A 212
 None
 0.78A 4twdF-1mhsA:
3.9
4twdG-1mhsA:
1.0
4twdH-1mhsA:
2.0
4twdI-1mhsA:
0.0
4twdJ-1mhsA:
0.0		 4twdF-1mhsA:
16.14
4twdG-1mhsA:
16.14
4twdH-1mhsA:
16.14
4twdI-1mhsA:
16.14
4twdJ-1mhsA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 ALA A 197
ALA A 201
ALA A 397
ALA A 399
ALA A 403
 None
 1.43A 4twdF-1ocmA:
0.0
4twdG-1ocmA:
0.0
4twdH-1ocmA:
0.0
4twdI-1ocmA:
0.0
4twdJ-1ocmA:
0.0		 4twdF-1ocmA:
22.14
4twdG-1ocmA:
22.14
4twdH-1ocmA:
22.14
4twdI-1ocmA:
22.14
4twdJ-1ocmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A  77
SER A 175
ALA A 350
ALA A 241
 None
 0.66A 4twdF-1tqyA:
undetectable
4twdG-1tqyA:
undetectable
4twdH-1tqyA:
undetectable
4twdI-1tqyA:
undetectable
4twdJ-1tqyA:
undetectable		 4twdF-1tqyA:
21.92
4twdG-1tqyA:
21.92
4twdH-1tqyA:
21.92
4twdI-1tqyA:
21.92
4twdJ-1tqyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 SER A 175
ALA A 350
ALA A 241
ALA A  77
 None
 0.77A 4twdF-1tqyA:
undetectable
4twdG-1tqyA:
undetectable
4twdH-1tqyA:
undetectable
4twdI-1tqyA:
undetectable
4twdJ-1tqyA:
undetectable		 4twdF-1tqyA:
21.92
4twdG-1tqyA:
21.92
4twdH-1tqyA:
21.92
4twdI-1tqyA:
21.92
4twdJ-1tqyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 ALA A  31
ALA A  58
ALA A  38
ALA A  34
 None
 0.70A 4twdF-1vbjA:
undetectable
4twdG-1vbjA:
undetectable
4twdH-1vbjA:
undetectable
4twdI-1vbjA:
undetectable
4twdJ-1vbjA:
undetectable		 4twdF-1vbjA:
20.12
4twdG-1vbjA:
20.12
4twdH-1vbjA:
20.12
4twdI-1vbjA:
20.12
4twdJ-1vbjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 ALA A  38
ALA A  34
ALA A  31
ALA A  58
 None
 0.80A 4twdF-1vbjA:
undetectable
4twdG-1vbjA:
undetectable
4twdH-1vbjA:
undetectable
4twdI-1vbjA:
undetectable
4twdJ-1vbjA:
undetectable		 4twdF-1vbjA:
20.12
4twdG-1vbjA:
20.12
4twdH-1vbjA:
20.12
4twdI-1vbjA:
20.12
4twdJ-1vbjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		4 ALA A  38
ALA A  34
ALA A  31
ALA A  58
 None
 0.80A 4twdF-1vbjA:
undetectable
4twdG-1vbjA:
undetectable
4twdH-1vbjA:
undetectable
4twdI-1vbjA:
undetectable
4twdJ-1vbjA:
undetectable		 4twdF-1vbjA:
20.12
4twdG-1vbjA:
20.12
4twdH-1vbjA:
20.12
4twdI-1vbjA:
20.12
4twdJ-1vbjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc1 L-ASPARTATE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		4 ALA A 165
SER A 168
ALA A  86
ALA A 153
 None
 0.78A 4twdF-2dc1A:
undetectable
4twdG-2dc1A:
undetectable
4twdH-2dc1A:
undetectable
4twdI-2dc1A:
undetectable
4twdJ-2dc1A:
undetectable		 4twdF-2dc1A:
22.04
4twdG-2dc1A:
22.04
4twdH-2dc1A:
22.04
4twdI-2dc1A:
22.04
4twdJ-2dc1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddw PYRIDOXINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		4 ALA A  13
SER A  11
ALA A  85
ALA A  16
 None
 0.79A 4twdF-2ddwA:
undetectable
4twdG-2ddwA:
undetectable
4twdH-2ddwA:
undetectable
4twdI-2ddwA:
undetectable
4twdJ-2ddwA:
undetectable		 4twdF-2ddwA:
23.44
4twdG-2ddwA:
23.44
4twdH-2ddwA:
23.44
4twdI-2ddwA:
23.44
4twdJ-2ddwA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ALA A  97
ALA A 293
ALA A 289
ALA A 287
 None
 0.78A 4twdF-2elcA:
undetectable
4twdG-2elcA:
undetectable
4twdH-2elcA:
undetectable
4twdI-2elcA:
undetectable
4twdJ-2elcA:
undetectable		 4twdF-2elcA:
21.98
4twdG-2elcA:
21.98
4twdH-2elcA:
21.98
4twdI-2elcA:
21.98
4twdJ-2elcA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 ALA A 180
ALA A 241
ALA A 262
ALA A 259
ALA A 265
 None
 1.44A 4twdF-2esnA:
undetectable
4twdG-2esnA:
undetectable
4twdH-2esnA:
undetectable
4twdI-2esnA:
undetectable
4twdJ-2esnA:
undetectable		 4twdF-2esnA:
21.76
4twdG-2esnA:
21.76
4twdH-2esnA:
21.76
4twdI-2esnA:
21.76
4twdJ-2esnA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 ALA A 155
ALA A 122
ALA A 118
ALA A 116
 None
 0.80A 4twdF-2gkoA:
undetectable
4twdG-2gkoA:
undetectable
4twdH-2gkoA:
undetectable
4twdI-2gkoA:
undetectable
4twdJ-2gkoA:
undetectable		 4twdF-2gkoA:
22.19
4twdG-2gkoA:
22.19
4twdH-2gkoA:
22.19
4twdI-2gkoA:
22.19
4twdJ-2gkoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 ALA A 155
ALA A 122
ALA A 118
ALA A 116
 None
 0.80A 4twdF-2gkoA:
undetectable
4twdG-2gkoA:
undetectable
4twdH-2gkoA:
undetectable
4twdI-2gkoA:
undetectable
4twdJ-2gkoA:
undetectable		 4twdF-2gkoA:
22.19
4twdG-2gkoA:
22.19
4twdH-2gkoA:
22.19
4twdI-2gkoA:
22.19
4twdJ-2gkoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		4 ALA A 193
ALA A 183
ALA A 200
ALA A 196
 None
 0.80A 4twdF-2gs9A:
undetectable
4twdG-2gs9A:
undetectable
4twdH-2gs9A:
undetectable
4twdI-2gs9A:
undetectable
4twdJ-2gs9A:
undetectable		 4twdF-2gs9A:
21.97
4twdG-2gs9A:
21.97
4twdH-2gs9A:
21.97
4twdI-2gs9A:
21.97
4twdJ-2gs9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk3 DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 105
ALA A 142
SER A 145
ALA A 110
 None
 0.67A 4twdF-2hk3A:
undetectable
4twdG-2hk3A:
1.3
4twdH-2hk3A:
undetectable
4twdI-2hk3A:
undetectable
4twdJ-2hk3A:
undetectable		 4twdF-2hk3A:
22.04
4twdG-2hk3A:
22.04
4twdH-2hk3A:
22.04
4twdI-2hk3A:
22.04
4twdJ-2hk3A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk3 DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 105
ALA A 142
SER A 145
ALA A 110
 None
 0.77A 4twdF-2hk3A:
undetectable
4twdG-2hk3A:
1.3
4twdH-2hk3A:
undetectable
4twdI-2hk3A:
undetectable
4twdJ-2hk3A:
undetectable		 4twdF-2hk3A:
22.04
4twdG-2hk3A:
22.04
4twdH-2hk3A:
22.04
4twdI-2hk3A:
22.04
4twdJ-2hk3A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifu GAMMA-SNAP

(Danio rerio) 		PF14938
(SNAP) 		5 ALA A  93
ALA A 120
ALA A 116
ALA A 100
SER A 101
 None
 1.26A 4twdF-2ifuA:
undetectable
4twdG-2ifuA:
undetectable
4twdH-2ifuA:
undetectable
4twdI-2ifuA:
undetectable
4twdJ-2ifuA:
undetectable		 4twdF-2ifuA:
20.82
4twdG-2ifuA:
20.82
4twdH-2ifuA:
20.82
4twdI-2ifuA:
20.82
4twdJ-2ifuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jer AGMATINE DEIMINASE

(Enterococcus
faecalis) 		PF04371
(PAD_porph) 		4 SER A 303
ALA A 223
ALA A 250
ALA A 246
 None
 0.79A 4twdF-2jerA:
undetectable
4twdG-2jerA:
undetectable
4twdH-2jerA:
undetectable
4twdI-2jerA:
undetectable
4twdJ-2jerA:
undetectable		 4twdF-2jerA:
21.81
4twdG-2jerA:
21.81
4twdH-2jerA:
21.81
4twdI-2jerA:
21.81
4twdJ-2jerA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3n TUSP1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		5 ALA A  14
ALA A  21
ALA A 115
SER A 116
ALA A 112
 None
 1.23A 4twdF-2k3nA:
undetectable
4twdG-2k3nA:
undetectable
4twdH-2k3nA:
undetectable
4twdI-2k3nA:
undetectable
4twdJ-2k3nA:
undetectable		 4twdF-2k3nA:
17.67
4twdG-2k3nA:
17.67
4twdH-2k3nA:
17.67
4twdI-2k3nA:
17.67
4twdJ-2k3nA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7g PROBABLE RNA
POLYMERASE SIGMA-C
FACTOR

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2) 		4 ALA A  25
ALA A  15
ALA A  32
ALA A  28
 None
 0.76A 4twdF-2o7gA:
undetectable
4twdG-2o7gA:
undetectable
4twdH-2o7gA:
undetectable
4twdI-2o7gA:
undetectable
4twdJ-2o7gA:
undetectable		 4twdF-2o7gA:
16.50
4twdG-2o7gA:
16.50
4twdH-2o7gA:
16.50
4twdI-2o7gA:
16.50
4twdJ-2o7gA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		4 ALA A 277
ALA A 270
ALA A 324
ALA A 298
 None
 0.72A 4twdF-2puzA:
undetectable
4twdG-2puzA:
undetectable
4twdH-2puzA:
undetectable
4twdI-2puzA:
undetectable
4twdJ-2puzA:
undetectable		 4twdF-2puzA:
20.23
4twdG-2puzA:
20.23
4twdH-2puzA:
20.23
4twdI-2puzA:
20.23
4twdJ-2puzA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		4 ALA A 324
ALA A 298
ALA A 277
ALA A 270
 None
 0.73A 4twdF-2puzA:
undetectable
4twdG-2puzA:
undetectable
4twdH-2puzA:
undetectable
4twdI-2puzA:
undetectable
4twdJ-2puzA:
undetectable		 4twdF-2puzA:
20.23
4twdG-2puzA:
20.23
4twdH-2puzA:
20.23
4twdI-2puzA:
20.23
4twdJ-2puzA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		5 ALA A 212
ALA A 238
ALA A 135
ALA A 137
ALA A 120
 None
 1.25A 4twdF-2q74A:
2.1
4twdG-2q74A:
undetectable
4twdH-2q74A:
undetectable
4twdI-2q74A:
undetectable
4twdJ-2q74A:
undetectable		 4twdF-2q74A:
20.87
4twdG-2q74A:
20.87
4twdH-2q74A:
20.87
4twdI-2q74A:
20.87
4twdJ-2q74A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN

(Thermosynechococcus
elongatus) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		4 ALA A  98
ALA A 121
ALA A 118
ALA A 102
 None
 0.68A 4twdF-2rq6A:
2.5
4twdG-2rq6A:
undetectable
4twdH-2rq6A:
undetectable
4twdI-2rq6A:
undetectable
4twdJ-2rq6A:
undetectable		 4twdF-2rq6A:
17.72
4twdG-2rq6A:
17.72
4twdH-2rq6A:
17.72
4twdI-2rq6A:
17.72
4twdJ-2rq6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN

(Thermosynechococcus
elongatus) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		4 ALA A 118
ALA A 102
ALA A  98
ALA A 121
 None
 0.67A 4twdF-2rq6A:
2.5
4twdG-2rq6A:
undetectable
4twdH-2rq6A:
undetectable
4twdI-2rq6A:
undetectable
4twdJ-2rq6A:
undetectable		 4twdF-2rq6A:
17.72
4twdG-2rq6A:
17.72
4twdH-2rq6A:
17.72
4twdI-2rq6A:
17.72
4twdJ-2rq6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq6 ATP SYNTHASE EPSILON
CHAIN

(Thermosynechococcus
elongatus) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		4 ALA A 121
ALA A 118
ALA A 102
ALA A  98
 None
 0.73A 4twdF-2rq6A:
2.5
4twdG-2rq6A:
undetectable
4twdH-2rq6A:
undetectable
4twdI-2rq6A:
undetectable
4twdJ-2rq6A:
undetectable		 4twdF-2rq6A:
17.72
4twdG-2rq6A:
17.72
4twdH-2rq6A:
17.72
4twdI-2rq6A:
17.72
4twdJ-2rq6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alt LECTIN CEL-IV,
C-TYPE

(Cucumaria
echinata) 		PF00059
(Lectin_C) 		4 ALA A 123
ALA A 135
SER A 130
ALA A  80
 None
MLB  A 301 ( 3.9A)
None
None
 0.80A 4twdF-3altA:
undetectable
4twdG-3altA:
undetectable
4twdH-3altA:
undetectable
4twdI-3altA:
undetectable
4twdJ-3altA:
undetectable		 4twdF-3altA:
17.10
4twdG-3altA:
17.10
4twdH-3altA:
17.10
4twdI-3altA:
17.10
4twdJ-3altA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alt LECTIN CEL-IV,
C-TYPE

(Cucumaria
echinata) 		PF00059
(Lectin_C) 		4 ALA A 135
SER A 130
ALA A  80
ALA A 123
 MLB  A 301 ( 3.9A)
None
None
None
 0.67A 4twdF-3altA:
undetectable
4twdG-3altA:
undetectable
4twdH-3altA:
undetectable
4twdI-3altA:
undetectable
4twdJ-3altA:
undetectable		 4twdF-3altA:
17.10
4twdG-3altA:
17.10
4twdH-3altA:
17.10
4twdI-3altA:
17.10
4twdJ-3altA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 ALA A 596
SER A 638
SER A 634
ALA A 602
 None
 0.77A 4twdF-3aqpA:
1.4
4twdG-3aqpA:
0.6
4twdH-3aqpA:
0.7
4twdI-3aqpA:
1.7
4twdJ-3aqpA:
undetectable		 4twdF-3aqpA:
19.92
4twdG-3aqpA:
19.92
4twdH-3aqpA:
19.92
4twdI-3aqpA:
19.92
4twdJ-3aqpA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ALA A 200
ALA A 135
SER A 156
ALA A 145
 None
 0.77A 4twdF-3d1jA:
undetectable
4twdG-3d1jA:
undetectable
4twdH-3d1jA:
undetectable
4twdI-3d1jA:
undetectable
4twdJ-3d1jA:
undetectable		 4twdF-3d1jA:
21.69
4twdG-3d1jA:
21.69
4twdH-3d1jA:
21.69
4twdI-3d1jA:
21.69
4twdJ-3d1jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6s ALLERGEN DER F I

(Dermatophagoides
farinae) 		PF00112
(Peptidase_C1) 		4 ALA A 140
ALA A 172
SER A 192
ALA A  43
 None
 0.80A 4twdF-3d6sA:
undetectable
4twdG-3d6sA:
undetectable
4twdH-3d6sA:
undetectable
4twdI-3d6sA:
undetectable
4twdJ-3d6sA:
undetectable		 4twdF-3d6sA:
19.48
4twdG-3d6sA:
19.48
4twdH-3d6sA:
19.48
4twdI-3d6sA:
19.48
4twdJ-3d6sA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 ALA A 120
SER A 215
ALA A 153
ALA A 114
ALA A 116
 None
None
None
PLP  A 450 (-3.5A)
None
 1.23A 4twdF-3du4A:
undetectable
4twdG-3du4A:
undetectable
4twdH-3du4A:
0.3
4twdI-3du4A:
undetectable
4twdJ-3du4A:
undetectable		 4twdF-3du4A:
21.63
4twdG-3du4A:
21.63
4twdH-3du4A:
21.63
4twdI-3du4A:
21.63
4twdJ-3du4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		5 ALA X  29
SER X 149
ALA X 111
ALA X  38
ALA X  36
 None
 1.09A 4twdF-3dwoX:
undetectable
4twdG-3dwoX:
undetectable
4twdH-3dwoX:
undetectable
4twdI-3dwoX:
undetectable
4twdJ-3dwoX:
undetectable		 4twdF-3dwoX:
23.67
4twdG-3dwoX:
23.67
4twdH-3dwoX:
23.67
4twdI-3dwoX:
23.67
4twdJ-3dwoX:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		5 ALA A  27
ALA A 475
ALA A 471
ALA A 375
SER A 377
 None
 1.30A 4twdF-3foaA:
undetectable
4twdG-3foaA:
undetectable
4twdH-3foaA:
undetectable
4twdI-3foaA:
undetectable
4twdJ-3foaA:
undetectable		 4twdF-3foaA:
20.39
4twdG-3foaA:
20.39
4twdH-3foaA:
20.39
4twdI-3foaA:
20.39
4twdJ-3foaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		5 ALA A 475
ALA A 471
ALA A 375
SER A 377
ALA A  27
 None
 1.22A 4twdF-3foaA:
undetectable
4twdG-3foaA:
undetectable
4twdH-3foaA:
undetectable
4twdI-3foaA:
undetectable
4twdJ-3foaA:
undetectable		 4twdF-3foaA:
20.39
4twdG-3foaA:
20.39
4twdH-3foaA:
20.39
4twdI-3foaA:
20.39
4twdJ-3foaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0u PHOSPHOTHREONINE
LYASE OSPF

(Shigella
flexneri) 		PF03536
(VRP3) 		4 ALA A 151
SER A 106
SER A 209
ALA A 197
 None
 0.60A 4twdF-3i0uA:
undetectable
4twdG-3i0uA:
undetectable
4twdH-3i0uA:
undetectable
4twdI-3i0uA:
undetectable
4twdJ-3i0uA:
undetectable		 4twdF-3i0uA:
21.54
4twdG-3i0uA:
21.54
4twdH-3i0uA:
21.54
4twdI-3i0uA:
21.54
4twdJ-3i0uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0u PHOSPHOTHREONINE
LYASE OSPF

(Shigella
flexneri) 		PF03536
(VRP3) 		4 ALA A 151
SER A 106
SER A 209
ALA A 197
 None
 0.75A 4twdF-3i0uA:
undetectable
4twdG-3i0uA:
undetectable
4twdH-3i0uA:
undetectable
4twdI-3i0uA:
undetectable
4twdJ-3i0uA:
undetectable		 4twdF-3i0uA:
21.54
4twdG-3i0uA:
21.54
4twdH-3i0uA:
21.54
4twdI-3i0uA:
21.54
4twdJ-3i0uA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1c DIISOPROPYL-FLUOROPH
OSPHATASE

(Loligo vulgaris) 		PF08450
(SGL) 		4 ALA A 229
ALA A 272
ALA A 120
ALA A 175
 None
 0.78A 4twdF-3i1cA:
undetectable
4twdG-3i1cA:
undetectable
4twdH-3i1cA:
undetectable
4twdI-3i1cA:
undetectable
4twdJ-3i1cA:
undetectable		 4twdF-3i1cA:
20.92
4twdG-3i1cA:
20.92
4twdH-3i1cA:
20.92
4twdI-3i1cA:
20.92
4twdJ-3i1cA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 ALA U  27
ALA U 475
ALA U 471
ALA U 375
SER U 377
 None
 1.30A 4twdF-3j2nU:
0.8
4twdG-3j2nU:
0.1
4twdH-3j2nU:
0.1
4twdI-3j2nU:
undetectable
4twdJ-3j2nU:
undetectable		 4twdF-3j2nU:
18.44
4twdG-3j2nU:
18.44
4twdH-3j2nU:
18.44
4twdI-3j2nU:
18.44
4twdJ-3j2nU:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		5 ALA U 475
ALA U 471
ALA U 375
SER U 377
ALA U  27
 None
 1.22A 4twdF-3j2nU:
0.8
4twdG-3j2nU:
0.1
4twdH-3j2nU:
0.1
4twdI-3j2nU:
undetectable
4twdJ-3j2nU:
undetectable		 4twdF-3j2nU:
18.44
4twdG-3j2nU:
18.44
4twdH-3j2nU:
18.44
4twdI-3j2nU:
18.44
4twdJ-3j2nU:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 ALA A 155
SER A 314
SER A 165
ALA A 158
 None
 0.72A 4twdF-3tefA:
undetectable
4twdG-3tefA:
undetectable
4twdH-3tefA:
undetectable
4twdI-3tefA:
undetectable
4twdJ-3tefA:
undetectable		 4twdF-3tefA:
21.75
4twdG-3tefA:
21.75
4twdH-3tefA:
21.75
4twdI-3tefA:
21.75
4twdJ-3tefA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 ALA A 155
SER A 314
SER A 165
ALA A 158
 None
 0.75A 4twdF-3tefA:
undetectable
4twdG-3tefA:
undetectable
4twdH-3tefA:
undetectable
4twdI-3tefA:
undetectable
4twdJ-3tefA:
undetectable		 4twdF-3tefA:
21.75
4twdG-3tefA:
21.75
4twdH-3tefA:
21.75
4twdI-3tefA:
21.75
4twdJ-3tefA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Bacillus
anthracis) 		PF00227
(Proteasome) 		4 ALA A 139
ALA A 159
ALA A 147
ALA A 142
 None
 0.73A 4twdF-3ty6A:
undetectable
4twdG-3ty6A:
undetectable
4twdH-3ty6A:
undetectable
4twdI-3ty6A:
undetectable
4twdJ-3ty6A:
undetectable		 4twdF-3ty6A:
21.00
4twdG-3ty6A:
21.00
4twdH-3ty6A:
21.00
4twdI-3ty6A:
21.00
4twdJ-3ty6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty6 ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV

(Bacillus
anthracis) 		PF00227
(Proteasome) 		4 ALA A 147
ALA A 142
ALA A 139
ALA A 159
 None
 0.76A 4twdF-3ty6A:
undetectable
4twdG-3ty6A:
undetectable
4twdH-3ty6A:
undetectable
4twdI-3ty6A:
undetectable
4twdJ-3ty6A:
undetectable		 4twdF-3ty6A:
21.00
4twdG-3ty6A:
21.00
4twdH-3ty6A:
21.00
4twdI-3ty6A:
21.00
4twdJ-3ty6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 ALA A 384
ALA A 374
ALA A1167
SER A1195
 None
 0.78A 4twdF-3ummA:
0.7
4twdG-3ummA:
undetectable
4twdH-3ummA:
undetectable
4twdI-3ummA:
undetectable
4twdJ-3ummA:
undetectable		 4twdF-3ummA:
12.97
4twdG-3ummA:
12.97
4twdH-3ummA:
12.97
4twdI-3ummA:
12.97
4twdJ-3ummA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 ALA A 224
SER A 257
ALA A 111
SER A 105
 None
 0.76A 4twdF-3wzfA:
undetectable
4twdG-3wzfA:
undetectable
4twdH-3wzfA:
undetectable
4twdI-3wzfA:
undetectable
4twdJ-3wzfA:
undetectable		 4twdF-3wzfA:
22.28
4twdG-3wzfA:
22.28
4twdH-3wzfA:
22.28
4twdI-3wzfA:
22.28
4twdJ-3wzfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 ALA A 558
ALA A 310
SER A 313
ALA A 306
ALA A 554
 None
 1.50A 4twdF-4a01A:
2.1
4twdG-4a01A:
0.1
4twdH-4a01A:
0.4
4twdI-4a01A:
undetectable
4twdJ-4a01A:
undetectable		 4twdF-4a01A:
17.15
4twdG-4a01A:
17.15
4twdH-4a01A:
17.15
4twdI-4a01A:
17.15
4twdJ-4a01A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 SER A 713
ALA A 719
ALA A 437
ALA A 705
 None
 0.78A 4twdF-4a01A:
2.1
4twdG-4a01A:
0.1
4twdH-4a01A:
0.4
4twdI-4a01A:
undetectable
4twdJ-4a01A:
undetectable		 4twdF-4a01A:
17.15
4twdG-4a01A:
17.15
4twdH-4a01A:
17.15
4twdI-4a01A:
17.15
4twdJ-4a01A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ALA A  93
ALA A  89
SER A  87
ALA A  64
ALA A 125
 None
 1.21A 4twdF-4bx0A:
undetectable
4twdG-4bx0A:
undetectable
4twdH-4bx0A:
undetectable
4twdI-4bx0A:
undetectable
4twdJ-4bx0A:
undetectable		 4twdF-4bx0A:
21.76
4twdG-4bx0A:
21.76
4twdH-4bx0A:
21.76
4twdI-4bx0A:
21.76
4twdJ-4bx0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		4 ALA A 105
ALA A 142
SER A 145
ALA A 110
 None
 0.66A 4twdF-4dpyA:
0.9
4twdG-4dpyA:
1.3
4twdH-4dpyA:
undetectable
4twdI-4dpyA:
undetectable
4twdJ-4dpyA:
undetectable		 4twdF-4dpyA:
21.63
4twdG-4dpyA:
21.63
4twdH-4dpyA:
21.63
4twdI-4dpyA:
21.63
4twdJ-4dpyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		4 ALA A 105
ALA A 142
SER A 145
ALA A 110
 None
 0.69A 4twdF-4dpyA:
0.9
4twdG-4dpyA:
1.3
4twdH-4dpyA:
undetectable
4twdI-4dpyA:
undetectable
4twdJ-4dpyA:
undetectable		 4twdF-4dpyA:
21.63
4twdG-4dpyA:
21.63
4twdH-4dpyA:
21.63
4twdI-4dpyA:
21.63
4twdJ-4dpyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Staphylococcus
epidermidis) 		PF00288
(GHMP_kinases_N) 		4 ALA A 142
SER A 145
ALA A 110
ALA A 105
 None
 0.70A 4twdF-4dpyA:
0.9
4twdG-4dpyA:
1.3
4twdH-4dpyA:
undetectable
4twdI-4dpyA:
undetectable
4twdJ-4dpyA:
undetectable		 4twdF-4dpyA:
21.63
4twdG-4dpyA:
21.63
4twdH-4dpyA:
21.63
4twdI-4dpyA:
21.63
4twdJ-4dpyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 ALA A 660
ALA A 658
SER A 561
ALA A 664
 None
None
None
EDO  A 815 (-3.2A)
 0.79A 4twdF-4fusA:
2.1
4twdG-4fusA:
0.4
4twdH-4fusA:
undetectable
4twdI-4fusA:
undetectable
4twdJ-4fusA:
undetectable		 4twdF-4fusA:
17.91
4twdG-4fusA:
17.91
4twdH-4fusA:
17.91
4twdI-4fusA:
17.91
4twdJ-4fusA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		4 ALA A 200
ALA A 375
ALA A 214
ALA A 212
 None
 0.75A 4twdF-4iheA:
undetectable
4twdG-4iheA:
undetectable
4twdH-4iheA:
undetectable
4twdI-4iheA:
undetectable
4twdJ-4iheA:
undetectable		 4twdF-4iheA:
22.95
4twdG-4iheA:
22.95
4twdH-4iheA:
22.95
4twdI-4iheA:
22.95
4twdJ-4iheA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Brachyspira
murdochii) 		PF13407
(Peripla_BP_4) 		4 ALA A 305
ALA A 301
ALA A  47
ALA A  51
 None
 0.78A 4twdF-4kqcA:
undetectable
4twdG-4kqcA:
undetectable
4twdH-4kqcA:
undetectable
4twdI-4kqcA:
undetectable
4twdJ-4kqcA:
undetectable		 4twdF-4kqcA:
23.16
4twdG-4kqcA:
23.16
4twdH-4kqcA:
23.16
4twdI-4kqcA:
23.16
4twdJ-4kqcA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 396
ALA A 306
SER A 416
ALA A 437
 None
 0.78A 4twdF-4ksiA:
0.4
4twdG-4ksiA:
undetectable
4twdH-4ksiA:
1.5
4twdI-4ksiA:
undetectable
4twdJ-4ksiA:
undetectable		 4twdF-4ksiA:
20.63
4twdG-4ksiA:
20.63
4twdH-4ksiA:
20.63
4twdI-4ksiA:
20.63
4twdJ-4ksiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyk CYCLIC DI-GMP
PHOSPHODIESTERASE
YAHA

(Escherichia
coli) 		PF00563
(EAL) 		4 ALA A 116
ALA A 112
ALA A 163
SER A 166
 None
 0.80A 4twdF-4lykA:
undetectable
4twdG-4lykA:
undetectable
4twdH-4lykA:
undetectable
4twdI-4lykA:
undetectable
4twdJ-4lykA:
undetectable		 4twdF-4lykA:
22.12
4twdG-4lykA:
22.12
4twdH-4lykA:
22.12
4twdI-4lykA:
22.12
4twdJ-4lykA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis) 		PF05690
(ThiG) 		4 ALA A 200
ALA A 204
ALA A 239
ALA A 232
 None
 0.76A 4twdF-4n6fA:
undetectable
4twdG-4n6fA:
undetectable
4twdH-4n6fA:
undetectable
4twdI-4n6fA:
undetectable
4twdJ-4n6fA:
undetectable		 4twdF-4n6fA:
23.93
4twdG-4n6fA:
23.93
4twdH-4n6fA:
23.93
4twdI-4n6fA:
23.93
4twdJ-4n6fA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5f TYPE III
PANTOTHENATE KINASE

(Burkholderia
thailandensis) 		PF03309
(Pan_kinase) 		4 ALA A 236
ALA A 232
ALA A 229
ALA A 203
 None
 0.80A 4twdF-4o5fA:
undetectable
4twdG-4o5fA:
undetectable
4twdH-4o5fA:
undetectable
4twdI-4o5fA:
undetectable
4twdJ-4o5fA:
undetectable		 4twdF-4o5fA:
20.12
4twdG-4o5fA:
20.12
4twdH-4o5fA:
20.12
4twdI-4o5fA:
20.12
4twdJ-4o5fA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		5 ALA A  78
ALA A  80
ALA A 124
SER A 127
ALA A  74
 None
 1.50A 4twdF-4od7A:
undetectable
4twdG-4od7A:
undetectable
4twdH-4od7A:
undetectable
4twdI-4od7A:
undetectable
4twdJ-4od7A:
undetectable		 4twdF-4od7A:
19.35
4twdG-4od7A:
19.35
4twdH-4od7A:
19.35
4twdI-4od7A:
19.35
4twdJ-4od7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry8 PERIPLASMIC BINDING
PROTEIN

(Pseudothermotoga
lettingae) 		PF13407
(Peripla_BP_4) 		4 ALA A  56
ALA A  60
ALA A 285
ALA A 281
 None
 0.77A 4twdF-4ry8A:
undetectable
4twdG-4ry8A:
undetectable
4twdH-4ry8A:
undetectable
4twdI-4ry8A:
undetectable
4twdJ-4ry8A:
undetectable		 4twdF-4ry8A:
21.65
4twdG-4ry8A:
21.65
4twdH-4ry8A:
21.65
4twdI-4ry8A:
21.65
4twdJ-4ry8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry8 PERIPLASMIC BINDING
PROTEIN

(Pseudothermotoga
lettingae) 		PF13407
(Peripla_BP_4) 		4 ALA A 285
ALA A 281
ALA A  56
ALA A  60
 None
 0.76A 4twdF-4ry8A:
undetectable
4twdG-4ry8A:
undetectable
4twdH-4ry8A:
undetectable
4twdI-4ry8A:
undetectable
4twdJ-4ry8A:
undetectable		 4twdF-4ry8A:
21.65
4twdG-4ry8A:
21.65
4twdH-4ry8A:
21.65
4twdI-4ry8A:
21.65
4twdJ-4ry8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		4 ALA A 428
ALA A 340
SER A 448
ALA A 469
 None
 0.77A 4twdF-5cbmA:
0.6
4twdG-5cbmA:
undetectable
4twdH-5cbmA:
undetectable
4twdI-5cbmA:
undetectable
4twdJ-5cbmA:
undetectable		 4twdF-5cbmA:
20.64
4twdG-5cbmA:
20.64
4twdH-5cbmA:
20.64
4twdI-5cbmA:
20.64
4twdJ-5cbmA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csc CITRATE SYNTHASE

(Gallus gallus) 		PF00285
(Citrate_synt) 		4 ALA B 245
SER B 248
SER B 412
ALA B 407
 None
 0.68A 4twdF-5cscB:
undetectable
4twdG-5cscB:
undetectable
4twdH-5cscB:
undetectable
4twdI-5cscB:
undetectable
4twdJ-5cscB:
undetectable		 4twdF-5cscB:
19.69
4twdG-5cscB:
19.69
4twdH-5cscB:
19.69
4twdI-5cscB:
19.69
4twdJ-5cscB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03170
(BcsB)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 ALA B 551
ALA B 580
SER A  40
ALA B 555
 None
 0.80A 4twdF-5ej1B:
undetectable
4twdG-5ej1B:
undetectable
4twdH-5ej1B:
undetectable
4twdI-5ej1B:
undetectable
4twdJ-5ej1B:
undetectable		 4twdF-5ej1B:
17.88
4twdG-5ej1B:
17.88
4twdH-5ej1B:
17.88
4twdI-5ej1B:
17.88
4twdJ-5ej1B:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03170
(BcsB)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 ALA B 580
SER A  40
ALA B 555
ALA B 551
 None
 0.81A 4twdF-5ej1B:
undetectable
4twdG-5ej1B:
undetectable
4twdH-5ej1B:
undetectable
4twdI-5ej1B:
undetectable
4twdJ-5ej1B:
undetectable		 4twdF-5ej1B:
17.88
4twdG-5ej1B:
17.88
4twdH-5ej1B:
17.88
4twdI-5ej1B:
17.88
4twdJ-5ej1B:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 138
ALA A 464
SER A 446
ALA A 466
ALA A 146
 None
 1.33A 4twdF-5fp2A:
undetectable
4twdG-5fp2A:
undetectable
4twdH-5fp2A:
undetectable
4twdI-5fp2A:
undetectable
4twdJ-5fp2A:
undetectable		 4twdF-5fp2A:
18.46
4twdG-5fp2A:
18.46
4twdH-5fp2A:
18.46
4twdI-5fp2A:
18.46
4twdJ-5fp2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 139
ALA A 463
SER A 445
ALA A 465
ALA A 147
 None
 1.19A 4twdF-5fr8A:
undetectable
4twdG-5fr8A:
undetectable
4twdH-5fr8A:
undetectable
4twdI-5fr8A:
undetectable
4twdJ-5fr8A:
undetectable		 4twdF-5fr8A:
20.06
4twdG-5fr8A:
20.06
4twdH-5fr8A:
20.06
4twdI-5fr8A:
20.06
4twdJ-5fr8A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrz TPR DOMAIN PROTEIN
1NA0C3_3

(synthetic
construct) 		PF13174
(TPR_6)
PF13432
(TPR_16) 		4 ALA A  56
ALA A  73
ALA A  63
ALA A  59
 None
 0.72A 4twdF-5hrzA:
undetectable
4twdG-5hrzA:
undetectable
4twdH-5hrzA:
undetectable
4twdI-5hrzA:
undetectable
4twdJ-5hrzA:
undetectable		 4twdF-5hrzA:
14.71
4twdG-5hrzA:
14.71
4twdH-5hrzA:
14.71
4twdI-5hrzA:
14.71
4twdJ-5hrzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrz TPR DOMAIN PROTEIN
1NA0C3_3

(synthetic
construct) 		PF13174
(TPR_6)
PF13432
(TPR_16) 		4 ALA A  63
ALA A  59
ALA A  56
ALA A  73
 None
 0.77A 4twdF-5hrzA:
undetectable
4twdG-5hrzA:
undetectable
4twdH-5hrzA:
undetectable
4twdI-5hrzA:
undetectable
4twdJ-5hrzA:
undetectable		 4twdF-5hrzA:
14.71
4twdG-5hrzA:
14.71
4twdH-5hrzA:
14.71
4twdI-5hrzA:
14.71
4twdJ-5hrzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrz TPR DOMAIN PROTEIN
1NA0C3_3

(synthetic
construct) 		PF13174
(TPR_6)
PF13432
(TPR_16) 		4 ALA A  73
ALA A  63
ALA A  59
ALA A  56
 None
 0.74A 4twdF-5hrzA:
undetectable
4twdG-5hrzA:
undetectable
4twdH-5hrzA:
undetectable
4twdI-5hrzA:
undetectable
4twdJ-5hrzA:
undetectable		 4twdF-5hrzA:
14.71
4twdG-5hrzA:
14.71
4twdH-5hrzA:
14.71
4twdI-5hrzA:
14.71
4twdJ-5hrzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrz TPR DOMAIN PROTEIN
1NA0C3_3

(synthetic
construct) 		PF13174
(TPR_6)
PF13432
(TPR_16) 		4 ALA A  73
ALA A  63
ALA A  59
ALA A  56
 None
 0.79A 4twdF-5hrzA:
undetectable
4twdG-5hrzA:
undetectable
4twdH-5hrzA:
undetectable
4twdI-5hrzA:
undetectable
4twdJ-5hrzA:
undetectable		 4twdF-5hrzA:
14.71
4twdG-5hrzA:
14.71
4twdH-5hrzA:
14.71
4twdI-5hrzA:
14.71
4twdJ-5hrzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		4 ALA A 210
SER A 256
ALA A 411
ALA A 261
 None
 0.70A 4twdF-5ixpA:
undetectable
4twdG-5ixpA:
undetectable
4twdH-5ixpA:
undetectable
4twdI-5ixpA:
undetectable
4twdJ-5ixpA:
undetectable		 4twdF-5ixpA:
21.62
4twdG-5ixpA:
21.62
4twdH-5ixpA:
21.62
4twdI-5ixpA:
21.62
4twdJ-5ixpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		4 ALA A 261
ALA A 210
SER A 256
ALA A 411
 None
 0.68A 4twdF-5ixpA:
undetectable
4twdG-5ixpA:
undetectable
4twdH-5ixpA:
undetectable
4twdI-5ixpA:
undetectable
4twdJ-5ixpA:
undetectable		 4twdF-5ixpA:
21.62
4twdG-5ixpA:
21.62
4twdH-5ixpA:
21.62
4twdI-5ixpA:
21.62
4twdJ-5ixpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixp EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Kribbella
flavida) 		PF13416
(SBP_bac_8) 		4 ALA A 261
ALA A 210
SER A 256
ALA A 411
 None
 0.68A 4twdF-5ixpA:
undetectable
4twdG-5ixpA:
undetectable
4twdH-5ixpA:
undetectable
4twdI-5ixpA:
undetectable
4twdJ-5ixpA:
undetectable		 4twdF-5ixpA:
21.62
4twdG-5ixpA:
21.62
4twdH-5ixpA:
21.62
4twdI-5ixpA:
21.62
4twdJ-5ixpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		4 ALA A 350
ALA A 381
ALA A 377
ALA A 353
 None
 0.75A 4twdF-5j90A:
undetectable
4twdG-5j90A:
undetectable
4twdH-5j90A:
0.1
4twdI-5j90A:
undetectable
4twdJ-5j90A:
undetectable		 4twdF-5j90A:
20.08
4twdG-5j90A:
20.08
4twdH-5j90A:
20.08
4twdI-5j90A:
20.08
4twdJ-5j90A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		4 ALA A 353
ALA A 350
ALA A 381
ALA A 377
 None
 0.80A 4twdF-5j90A:
undetectable
4twdG-5j90A:
undetectable
4twdH-5j90A:
0.1
4twdI-5j90A:
undetectable
4twdJ-5j90A:
undetectable		 4twdF-5j90A:
20.08
4twdG-5j90A:
20.08
4twdH-5j90A:
20.08
4twdI-5j90A:
20.08
4twdJ-5j90A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 4 ALA A 477
ALA A 481
ALA A 457
ALA A 454
 None
 0.79A 4twdF-5ovnA:
undetectable
4twdG-5ovnA:
undetectable
4twdH-5ovnA:
undetectable
4twdI-5ovnA:
undetectable
4twdJ-5ovnA:
undetectable		 4twdF-5ovnA:
14.38
4twdG-5ovnA:
14.38
4twdH-5ovnA:
14.38
4twdI-5ovnA:
14.38
4twdJ-5ovnA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7w APYRASE

(Trifolium
repens) 		PF01150
(GDA1_CD39) 		4 ALA A  87
SER A  18
ALA A  58
SER A  61
 None
 0.74A 4twdF-5u7wA:
undetectable
4twdG-5u7wA:
undetectable
4twdH-5u7wA:
undetectable
4twdI-5u7wA:
undetectable
4twdJ-5u7wA:
undetectable		 4twdF-5u7wA:
22.45
4twdG-5u7wA:
22.45
4twdH-5u7wA:
22.45
4twdI-5u7wA:
22.45
4twdJ-5u7wA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		4 ALA F  87
SER F  18
ALA F  58
SER F  61
 None
 0.77A 4twdF-5u7xF:
undetectable
4twdG-5u7xF:
undetectable
4twdH-5u7xF:
undetectable
4twdI-5u7xF:
undetectable
4twdJ-5u7xF:
undetectable		 4twdF-5u7xF:
21.53
4twdG-5u7xF:
21.53
4twdH-5u7xF:
21.53
4twdI-5u7xF:
21.53
4twdJ-5u7xF:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 230
ALA A 429
ALA A 238
ALA A 282
SER A 170
 None
 1.36A 4twdF-5vm1A:
undetectable
4twdG-5vm1A:
undetectable
4twdH-5vm1A:
undetectable
4twdI-5vm1A:
undetectable
4twdJ-5vm1A:
undetectable		 4twdF-5vm1A:
20.82
4twdG-5vm1A:
20.82
4twdH-5vm1A:
20.82
4twdI-5vm1A:
20.82
4twdJ-5vm1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydl PKS

(Streptomyces
sp. CNQ431) 		no annotation 4 ALA A  71
ALA A  67
ALA A  64
ALA A  21
 None
 0.81A 4twdF-5ydlA:
undetectable
4twdG-5ydlA:
undetectable
4twdH-5ydlA:
undetectable
4twdI-5ydlA:
undetectable
4twdJ-5ydlA:
undetectable		 4twdF-5ydlA:
15.46
4twdG-5ydlA:
15.46
4twdH-5ydlA:
15.46
4twdI-5ydlA:
15.46
4twdJ-5ydlA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens) 		no annotation 4 ALA B  93
ALA B  89
ALA B 127
ALA B 124
 None
 0.72A 4twdF-6ez8B:
undetectable
4twdG-6ez8B:
undetectable
4twdH-6ez8B:
undetectable
4twdI-6ez8B:
undetectable
4twdJ-6ez8B:
undetectable		 4twdF-6ez8B:
12.84
4twdG-6ez8B:
12.84
4twdH-6ez8B:
12.84
4twdI-6ez8B:
12.84
4twdJ-6ez8B:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens) 		no annotation 4 ALA B 127
ALA B 124
ALA B  93
ALA B  89
 None
 0.77A 4twdF-6ez8B:
undetectable
4twdG-6ez8B:
undetectable
4twdH-6ez8B:
undetectable
4twdI-6ez8B:
undetectable
4twdJ-6ez8B:
undetectable		 4twdF-6ez8B:
12.84
4twdG-6ez8B:
12.84
4twdH-6ez8B:
12.84
4twdI-6ez8B:
12.84
4twdJ-6ez8B:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens) 		no annotation 5 ALA B 128
ALA B 124
ALA B  93
ALA B  89
ALA B  87
 None
 1.32A 4twdF-6ez8B:
undetectable
4twdG-6ez8B:
undetectable
4twdH-6ez8B:
undetectable
4twdI-6ez8B:
undetectable
4twdJ-6ez8B:
undetectable		 4twdF-6ez8B:
12.84
4twdG-6ez8B:
12.84
4twdH-6ez8B:
12.84
4twdI-6ez8B:
12.84
4twdJ-6ez8B:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 5 ALA A1236
ALA A1188
ALA A1494
SER A1492
ALA A1306
 None
 1.46A 4twdF-6fayA:
undetectable
4twdG-6fayA:
undetectable
4twdH-6fayA:
undetectable
4twdI-6fayA:
undetectable
4twdJ-6fayA:
undetectable		 4twdF-6fayA:
18.57
4twdG-6fayA:
18.57
4twdH-6fayA:
18.57
4twdI-6fayA:
18.57
4twdJ-6fayA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ALA A1272
ALA A1449
ALA A1509
ALA A1578
 None
 0.73A 4twdF-6fb3A:
undetectable
4twdG-6fb3A:
undetectable
4twdH-6fb3A:
undetectable
4twdI-6fb3A:
undetectable
4twdJ-6fb3A:
undetectable		 4twdF-6fb3A:
11.96
4twdG-6fb3A:
11.96
4twdH-6fb3A:
11.96
4twdI-6fb3A:
11.96
4twdJ-6fb3A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ALA A1449
ALA A1509
ALA A1578
ALA A1272
 None
 0.77A 4twdF-6fb3A:
undetectable
4twdG-6fb3A:
undetectable
4twdH-6fb3A:
undetectable
4twdI-6fb3A:
undetectable
4twdJ-6fb3A:
undetectable		 4twdF-6fb3A:
11.96
4twdG-6fb3A:
11.96
4twdH-6fb3A:
11.96
4twdI-6fb3A:
11.96
4twdJ-6fb3A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ALA A1509
ALA A1578
ALA A1272
ALA A1449
 None
 0.79A 4twdF-6fb3A:
undetectable
4twdG-6fb3A:
undetectable
4twdH-6fb3A:
undetectable
4twdI-6fb3A:
undetectable
4twdJ-6fb3A:
undetectable		 4twdF-6fb3A:
11.96
4twdG-6fb3A:
11.96
4twdH-6fb3A:
11.96
4twdI-6fb3A:
11.96
4twdJ-6fb3A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 4 ALA A1578
ALA A1272
ALA A1449
ALA A1509
 None
 0.79A 4twdF-6fb3A:
undetectable
4twdG-6fb3A:
undetectable
4twdH-6fb3A:
undetectable
4twdI-6fb3A:
undetectable
4twdJ-6fb3A:
undetectable		 4twdF-6fb3A:
11.96
4twdG-6fb3A:
11.96
4twdH-6fb3A:
11.96
4twdI-6fb3A:
11.96
4twdJ-6fb3A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fth EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		no annotation 5 ALA A  84
ALA A  86
ALA A 129
SER A 332
ALA A 328
 None
 1.32A 4twdF-6fthA:
undetectable
4twdG-6fthA:
undetectable
4twdH-6fthA:
undetectable
4twdI-6fthA:
undetectable
4twdJ-6fthA:
undetectable		 4twdF-6fthA:
14.29
4twdG-6fthA:
14.29
4twdH-6fthA:
14.29
4twdI-6fthA:
14.29
4twdJ-6fthA:
14.29