SIMILAR PATTERNS OF AMINO ACIDS FOR 4TVT_A_ASCA305_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 LYS B 341
GLU B 385
PHE B 291
VAL B 290
 None
 1.42A 4tvtA-1lpbB:
0.0		 4tvtA-1lpbB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463

(Pyrococcus
horikoshii) 		PF01887
(SAM_adeno_trans) 		4 LYS A  99
GLU A  51
ILE A 176
PHE A  48
 None
 1.14A 4tvtA-1wu8A:
0.0		 4tvtA-1wu8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		4 GLU A 184
ILE A 182
PHE A 189
VAL A 191
 None
 1.25A 4tvtA-2as0A:
0.0		 4tvtA-2as0A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3j TRNA ADENOSINE
DEAMINASE

(Staphylococcus
aureus) 		PF14437
(MafB19-deam) 		4 LYS A  17
GLU A  14
ILE A  29
VAL A  36
 None
 1.24A 4tvtA-2b3jA:
undetectable		 4tvtA-2b3jA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A 241
ILE A 180
PHE A 228
VAL A 226
 None
 1.50A 4tvtA-2g17A:
0.0		 4tvtA-2g17A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LYS A 300
GLU A 297
ILE A  93
PHE A  90
 None
 1.25A 4tvtA-2ox4A:
0.0		 4tvtA-2ox4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 LYS A  11
GLU A 143
ILE A 193
VAL A 191
 None
 1.29A 4tvtA-3buzA:
0.0		 4tvtA-3buzA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		4 GLU A  95
ILE A  14
PHE A  18
VAL A  15
 None
 1.37A 4tvtA-3e9mA:
0.0		 4tvtA-3e9mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LYS A 352
ILE A 424
PHE A 423
VAL A 378
 None
 1.15A 4tvtA-3g7sA:
0.0		 4tvtA-3g7sA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on5 BH1974 PROTEIN

(Bacillus
halodurans) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		4 LYS A 122
ILE A 142
PHE A 125
VAL A 158
 None
 1.14A 4tvtA-3on5A:
undetectable		 4tvtA-3on5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0q PROBABLE PROTEIN
ARGININE
N-METHYLTRANSFERASE
4.2

(Arabidopsis
thaliana) 		no annotation 4 LYS C 255
ILE C 267
PHE C 155
VAL C 264
 None
 1.32A 4tvtA-3r0qC:
undetectable		 4tvtA-3r0qC:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbf PHIKZ131

(Pseudomonas
virus phiKZ) 		no annotation 4 GLU A 457
ILE A 558
PHE A 559
VAL A 573
 None
 1.22A 4tvtA-4gbfA:
undetectable		 4tvtA-4gbfA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyk DNA POLYMERASE IV

(Sulfolobus
acidocaldarius) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 GLU A 120
ILE A 123
PHE A 119
VAL A 166
 None
 1.29A 4tvtA-4hykA:
undetectable		 4tvtA-4hykA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 GLU A 369
ILE A 372
PHE A 468
VAL A 467
 None
 1.35A 4tvtA-4i8vA:
undetectable		 4tvtA-4i8vA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 GLU A 449
ILE A 179
PHE A 181
VAL A 158
 None
 1.49A 4tvtA-4je5A:
undetectable		 4tvtA-4je5A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lik DNA PRIMASE SMALL
SUBUNIT

(Homo sapiens) 		PF01896
(DNA_primase_S) 		4 LYS A 176
GLU A 103
ILE A  36
VAL A  35
 None
 1.46A 4tvtA-4likA:
undetectable		 4tvtA-4likA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfa LMO0740 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 GLU A 157
ILE A  67
PHE A  68
VAL A  53
 None
 1.44A 4tvtA-4rfaA:
undetectable		 4tvtA-4rfaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE

(Escherichia
coli) 		PF01928
(CYTH) 		4 LYS A   8
GLU A 158
PHE A 124
VAL A 147
 3PO  A1000 (-2.8A)
None
3PO  A1000 (-4.8A)
None
 1.31A 4tvtA-5a60A:
undetectable		 4tvtA-5a60A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeu BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Paraburkholderia
xenovorans) 		PF00866
(Ring_hydroxyl_B) 		4 GLU B  26
ILE B  27
PHE B 128
VAL B 119
 None
 1.44A 4tvtA-5aeuB:
undetectable		 4tvtA-5aeuB:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5amz THAUMATIN-1

(Thaumatococcus
daniellii) 		PF00314
(Thaumatin) 		5 LYS A  49
GLU A  89
ILE A 105
PHE A 181
VAL A 184
 None
 0.10A 4tvtA-5amzA:
40.9		 4tvtA-5amzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 GLU A 305
ILE A 386
PHE A 391
VAL A 369
 None
 1.35A 4tvtA-5hp5A:
undetectable		 4tvtA-5hp5A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6u BETA-MANNOSIDASE

(Dictyoglomus
thermophilum) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 LYS A 580
GLU A 584
ILE A 637
VAL A 706
 None
 1.44A 4tvtA-5n6uA:
undetectable		 4tvtA-5n6uA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nm9 MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG

(Trichoplax
adhaerens) 		no annotation 4 LYS A  44
GLU A  47
PHE A 111
VAL A 120
 None
 1.24A 4tvtA-5nm9A:
undetectable		 4tvtA-5nm9A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4b BOLA-LIKE PROTEIN 2

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A  98
ILE A  72
PHE A  70
VAL A  59
 None
 1.36A 4tvtA-5y4bA:
undetectable		 4tvtA-5y4bA:
undetectable