SIMILAR PATTERNS OF AMINO ACIDS FOR 4TVT_A_ASCA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b06 PROTEIN (SUPEROXIDE
DISMUTASE)

(Sulfolobus
acidocaldarius) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ARG A   8
GLN A   5
GLU A  53
 None
 0.91A 4tvtA-1b06A:
0.0		 4tvtA-1b06A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4j ANTIBODY

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L 142
GLN L 166
GLU L 165
 None
 0.91A 4tvtA-1b4jL:
0.0		 4tvtA-1b4jL:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG A 208
GLN A 508
GLU A 563
 None
 0.81A 4tvtA-1d6mA:
0.0		 4tvtA-1d6mA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 ARG A 244
GLN A 246
GLU A 272
 None
 0.79A 4tvtA-1ex0A:
0.7		 4tvtA-1ex0A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		3 ARG A 150
GLN A 109
GLU A 122
 None
 0.93A 4tvtA-1gl6A:
0.0		 4tvtA-1gl6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A  45
GLN A  46
GLU A 335
 None
 0.92A 4tvtA-1jvbA:
0.0		 4tvtA-1jvbA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		3 ARG D 463
GLN D 456
GLU D 199
 None
 0.92A 4tvtA-1mhzD:
0.0		 4tvtA-1mhzD:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mim CHIMERIC SDZ CHI621

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L 139
GLN L 163
GLU L 162
 None
 0.93A 4tvtA-1mimL:
0.5		 4tvtA-1mimL:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tba TRANSCRIPTION
INITIATION FACTOR
TFIID

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		3 ARG B 220
GLN B 219
GLU B 129
 None
 0.91A 4tvtA-1tbaB:
0.0		 4tvtA-1tbaB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ARG A  31
GLN A  22
GLU A  25
 None
 0.93A 4tvtA-1tqyA:
undetectable		 4tvtA-1tqyA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u60 PROBABLE GLUTAMINASE
YBAS

(Escherichia
coli) 		PF04960
(Glutaminase) 		3 ARG A 194
GLN A 137
GLU A 133
 None
 0.93A 4tvtA-1u60A:
undetectable		 4tvtA-1u60A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		3 ARG A 150
GLN A 159
GLU A 162
 None
 0.93A 4tvtA-1wf3A:
undetectable		 4tvtA-1wf3A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvi PUTATIVE
MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		3 ARG A  37
GLN A  64
GLU A  80
 None
 0.89A 4tvtA-1xviA:
undetectable		 4tvtA-1xviA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus musculus) 		PF00104
(Hormone_recep) 		3 ARG A 366
GLN A 317
GLU A 238
 None
 0.81A 4tvtA-1yp0A:
undetectable		 4tvtA-1yp0A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbo HYPOTHETICAL PROTEIN
BPP1347

(Bordetella
parapertussis) 		PF02190
(LON_substr_bdg) 		3 ARG A  27
GLN A  99
GLU A  60
 None
 0.93A 4tvtA-1zboA:
undetectable		 4tvtA-1zboA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzw DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		3 ARG A 384
GLN A 454
GLU A 457
 None
 0.88A 4tvtA-1zzwA:
undetectable		 4tvtA-1zzwA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4c CADHERIN-11

(Mus musculus) 		PF00028
(Cadherin) 		3 ARG A  68
GLN A  70
GLU A  42
 None
 0.69A 4tvtA-2a4cA:
undetectable		 4tvtA-2a4cA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4e CADHERIN-11

(Mus musculus) 		PF00028
(Cadherin) 		3 ARG A  68
GLN A  70
GLU A  42
 None
 0.78A 4tvtA-2a4eA:
undetectable		 4tvtA-2a4eA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		no annotation 3 ARG A 116
GLN A 318
GLU A 326
 None
 0.90A 4tvtA-2b2nA:
undetectable		 4tvtA-2b2nA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehb CALCINEURIN B-LIKE
PROTEIN 4
CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7)
PF03822
(NAF) 		3 ARG A  70
GLN D 320
GLU A 142
 None
 0.79A 4tvtA-2ehbA:
undetectable		 4tvtA-2ehbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eho GINS COMPLEX SUBUNIT
3

(Homo sapiens) 		PF05916
(Sld5) 		3 ARG D  97
GLN D  93
GLU D 130
 None
 0.80A 4tvtA-2ehoD:
undetectable		 4tvtA-2ehoD:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		3 ARG A 250
GLN A 244
GLU A 234
 None
 0.79A 4tvtA-2hxgA:
undetectable		 4tvtA-2hxgA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jer AGMATINE DEIMINASE

(Enterococcus
faecalis) 		PF04371
(PAD_porph) 		3 ARG A  16
GLN A 166
GLU A  22
 None
 0.78A 4tvtA-2jerA:
undetectable		 4tvtA-2jerA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		3 ARG A 202
GLN A 206
GLU A 177
 None
 0.91A 4tvtA-2jh9A:
undetectable		 4tvtA-2jh9A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvf 2S ALBUMIN

(Bertholletia
excelsa) 		PF00234
(Tryp_alpha_amyl) 		3 ARG A  14
GLN A  11
GLU A  10
 None
 0.71A 4tvtA-2lvfA:
undetectable		 4tvtA-2lvfA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcd MURINE NOROVIRUS 1

(Norwalk virus) 		no annotation 3 ARG A  80
GLN A  56
GLU A  54
 None
 0.85A 4tvtA-2mcdA:
undetectable		 4tvtA-2mcdA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		3 ARG X 197
GLN X 318
GLU X 322
 None
 0.93A 4tvtA-2p4hX:
undetectable		 4tvtA-2p4hX:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtz METHIONINE SYNTHASE
REDUCTASE

(Homo sapiens) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 ARG A 451
GLN A 449
GLU A 375
 FAD  A 700 (-3.9A)
None
None
 0.81A 4tvtA-2qtzA:
undetectable		 4tvtA-2qtzA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyk PROTEIN TDCF

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		3 ARG A  51
GLN A  93
GLU A  97
 None
 0.80A 4tvtA-2uykA:
undetectable		 4tvtA-2uykA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 ARG A 274
GLN A 271
GLU A 270
 None
 0.87A 4tvtA-2vz9A:
undetectable		 4tvtA-2vz9A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ARG A 313
GLN A 800
GLU A 719
 None
 0.65A 4tvtA-2wyhA:
undetectable		 4tvtA-2wyhA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtj FAB FROM A HUMAN
MONOCLONAL ANTIBODY,
1D05

(Homo sapiens) 		PF07654
(C1-set) 		3 ARG C 141
GLN C 165
GLU C 164
 None
 0.87A 4tvtA-2xtjC:
undetectable		 4tvtA-2xtjC:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 3 ARG A 144
GLN A 161
GLU A 160
 None
 0.84A 4tvtA-2y4lA:
undetectable		 4tvtA-2y4lA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax1 SERRATE RNA EFFECTOR
MOLECULE

(Arabidopsis
thaliana) 		PF04959
(ARS2)
PF12066
(DUF3546) 		3 ARG A 458
GLN A 462
GLU A 356
 None
 0.91A 4tvtA-3ax1A:
undetectable		 4tvtA-3ax1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl2 V-BCL-2

(Murid
gammaherpesvirus
4) 		PF15286
(Bcl-2_3) 		3 ARG A  49
GLN A  46
GLU A 100
 None
 0.86A 4tvtA-3bl2A:
undetectable		 4tvtA-3bl2A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 ARG A 134
GLN A1016
GLU A 127
 None
 0.93A 4tvtA-3cmuA:
undetectable		 4tvtA-3cmuA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 ARG A1134
GLN A2016
GLU A1127
 None
 0.92A 4tvtA-3cmuA:
undetectable		 4tvtA-3cmuA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 ARG A2134
GLN A3016
GLU A2127
 None
 0.92A 4tvtA-3cmuA:
undetectable		 4tvtA-3cmuA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		3 ARG A3134
GLN A4016
GLU A3127
 None
 0.90A 4tvtA-3cmuA:
undetectable		 4tvtA-3cmuA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		3 ARG A 554
GLN A 431
GLU A 432
 PO4  A   2 (-3.9A)
None
None
 0.84A 4tvtA-3f41A:
undetectable		 4tvtA-3f41A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		3 ARG A  49
GLN A  46
GLU A  41
 None
 0.84A 4tvtA-3fmqA:
undetectable		 4tvtA-3fmqA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		3 ARG A 313
GLN A  96
GLU A  95
 None
 0.83A 4tvtA-3gs6A:
undetectable		 4tvtA-3gs6A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4

(Homo sapiens) 		no annotation 3 ARG A 373
GLN A 364
GLU A 366
 None
 0.90A 4tvtA-3l15A:
undetectable		 4tvtA-3l15A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhp FERREDOXIN--NADP
REDUCTASE, LEAF
ISOZYME,
CHLOROPLASTIC

(Pisum sativum) 		PF00175
(NAD_binding_1) 		3 ARG A  65
GLN A  17
GLU A  19
 None
 0.77A 4tvtA-3mhpA:
undetectable		 4tvtA-3mhpA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moz MYO-INOSITOL
HEXAPHOSPHATE
PHOSPHOHYDROLASE

(Selenomonas
ruminantium) 		PF14566
(PTPlike_phytase) 		3 ARG A 258
GLN A 135
GLU A 136
 PO4  A 400 (-3.9A)
None
None
 0.86A 4tvtA-3mozA:
undetectable		 4tvtA-3mozA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4d CEA-RELATED CELL
ADHESION MOLECULE 1,
ISOFORM 1/2S

(Mus musculus) 		PF07686
(V-set)
PF13927
(Ig_3) 		3 ARG A  97
GLN A  99
GLU A   1
 None
 0.83A 4tvtA-3r4dA:
undetectable		 4tvtA-3r4dA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1d ATLASTIN

(Drosophila
melanogaster) 		PF02263
(GBP) 		3 ARG A 229
GLN A 226
GLU A 159
 None
 0.81A 4tvtA-3x1dA:
undetectable		 4tvtA-3x1dA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1o ROQUIN-1

(Homo sapiens) 		no annotation 3 ARG A 251
GLN A 289
GLU A 293
 None
 0.87A 4tvtA-3x1oA:
undetectable		 4tvtA-3x1oA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 ARG A 379
GLN A 375
GLU A 331
 None
 0.72A 4tvtA-3zhyA:
undetectable		 4tvtA-3zhyA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajv TRANSFORMING GROWTH
FACTOR BETA RECEPTOR
TYPE 3

(Mus musculus) 		PF00100
(Zona_pellucida) 		3 ARG A 711
GLN A 629
GLU A 681
 None
 0.83A 4tvtA-4ajvA:
undetectable		 4tvtA-4ajvA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arr TOLL RECEPTOR,
VARIABLE LYMPHOCYTE
RECEPTOR B.61
CHIMERA

(Drosophila
melanogaster;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		3 ARG A 210
GLN A 211
GLU A 187
 None
 0.93A 4tvtA-4arrA:
undetectable		 4tvtA-4arrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bil DNA MATURASE B

(Escherichia
virus T7) 		no annotation 3 ARG A 368
GLN A 358
GLU A 389
 None
 0.89A 4tvtA-4bilA:
undetectable		 4tvtA-4bilA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		3 ARG A  83
GLN A  81
GLU A  38
 None
 0.86A 4tvtA-4bl3A:
undetectable		 4tvtA-4bl3A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR

(Thermoproteus
tenax) 		no annotation 3 ARG A  26
GLN A  33
GLU A  36
 None
 0.91A 4tvtA-4csoA:
undetectable		 4tvtA-4csoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		3 ARG A 464
GLN A 132
GLU A 202
 GOL  A 504 (-3.8A)
None
GOL  A 504 (-3.7A)
 0.86A 4tvtA-4dweA:
undetectable		 4tvtA-4dweA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esp PROFILIN

(Arachis
hypogaea) 		PF00235
(Profilin) 		3 ARG A  84
GLN A  76
GLU A  78
 None
 0.92A 4tvtA-4espA:
undetectable		 4tvtA-4espA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 ARG A  92
GLN A  88
GLU A 356
 None
 0.78A 4tvtA-4ewjA:
undetectable		 4tvtA-4ewjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqg TRANSCRIPTION
ELONGATION REGULATOR
1

(Homo sapiens) 		PF01846
(FF) 		3 ARG A  98
GLN A  72
GLU A  76
 None
 0.78A 4tvtA-4fqgA:
undetectable		 4tvtA-4fqgA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 3 ARG A  37
GLN A  72
GLU A  73
 None
 0.94A 4tvtA-4fyeA:
undetectable		 4tvtA-4fyeA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 2,3-DEHYDROADIPYL-CO
A HYDRATASE

(Escherichia
coli) 		PF00378
(ECH_1) 		3 ARG A 210
GLN A 213
GLU A 214
 None
 0.89A 4tvtA-4fzwA:
undetectable		 4tvtA-4fzwA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1j SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		3 ARG A 139
GLN A 113
GLU A 112
 None
 0.84A 4tvtA-4g1jA:
undetectable		 4tvtA-4g1jA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ARG A 381
GLN A 383
GLU A 553
 None
 0.81A 4tvtA-4hozA:
undetectable		 4tvtA-4hozA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ild ENVELOPE
GLYCOPROTEIN E2

(Pestivirus A) 		PF16329
(Pestivirus_E2) 		3 ARG A 857
GLN A 858
GLU A 792
 None
 0.82A 4tvtA-4ildA:
undetectable		 4tvtA-4ildA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		3 ARG A 236
GLN A 160
GLU A 163
 None
 0.82A 4tvtA-4mydA:
undetectable		 4tvtA-4mydA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT

(Escherichia
coli;
Mus musculus) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		3 ARG A 346
GLN A1143
GLU A  47
 None
 0.87A 4tvtA-4nufA:
undetectable		 4tvtA-4nufA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nx8 PROTEIN-TYROSINE
PHOSPHATASE 2

(Bdellovibrio
bacteriovorus) 		PF14566
(PTPlike_phytase) 		3 ARG A 212
GLN A 102
GLU A 103
 None
 0.88A 4tvtA-4nx8A:
undetectable		 4tvtA-4nx8A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 ARG A2007
GLN A1988
GLU A1715
 None
 0.76A 4tvtA-4o9xA:
undetectable		 4tvtA-4o9xA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E
TYPE II SECRETION
SYSTEM PROTEIN L

(Vibrio
vulnificus;
Vibrio
vulnificus) 		PF00437
(T2SSE)
PF05134
(T2SSL) 		3 ARG A  52
GLN A  57
GLU X  12
 None
 0.72A 4tvtA-4phtA:
undetectable		 4tvtA-4phtA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9z UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		3 ARG A  89
GLN A  81
GLU A  82
 None
 0.81A 4tvtA-4r9zA:
undetectable		 4tvtA-4r9zA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdq BESTROPHIN-1

(Gallus gallus) 		PF01062
(Bestrophin) 		3 ARG A 125
GLN A 327
GLU A 117
 None
 0.87A 4tvtA-4rdqA:
undetectable		 4tvtA-4rdqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsi STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
2
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF06470
(SMC_hinge)
PF06470
(SMC_hinge) 		3 ARG B 653
GLN B 646
GLU A 498
 None
 0.88A 4tvtA-4rsiB:
undetectable		 4tvtA-4rsiB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN

(Legionella
pneumophila) 		PF14566
(PTPlike_phytase) 		3 ARG A 237
GLN A 110
GLU A 111
 PO4  A 402 (-3.8A)
None
None
 0.89A 4tvtA-4tvvA:
undetectable		 4tvtA-4tvvA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 ARG A  69
GLN A 111
GLU A 118
 None
 0.93A 4tvtA-4v2xA:
undetectable		 4tvtA-4v2xA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yco TRNA-DIHYDROURIDINE
SYNTHASE C

(Escherichia
coli) 		PF01207
(Dus) 		3 ARG A 177
GLN A 174
GLU A 173
 None
 0.85A 4tvtA-4ycoA:
undetectable		 4tvtA-4ycoA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi LIGHT CHAIN OF
ANTIBODY
Z258-VRC27.01

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG L 142
GLN L 166
GLU L 165
 None
 0.75A 4tvtA-4ydiL:
undetectable		 4tvtA-4ydiL:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 ARG A 209
GLN A 207
GLU A 134
 None
 0.81A 4tvtA-4zmhA:
2.4		 4tvtA-4zmhA:
12.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5amz THAUMATIN-1

(Thaumatococcus
daniellii) 		PF00314
(Thaumatin) 		3 ARG A  29
GLN A  30
GLU A  35
 None
 0.13A 4tvtA-5amzA:
40.9		 4tvtA-5amzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvr ALPHA-ACTININ-LIKE
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		3 ARG A  25
GLN A  45
GLU A  48
 None
 0.75A 4tvtA-5bvrA:
undetectable		 4tvtA-5bvrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		3 ARG A  41
GLN A  77
GLU A  80
 None
 0.75A 4tvtA-5c2iA:
undetectable		 4tvtA-5c2iA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		3 ARG A 281
GLN A 283
GLU A 287
 None
 0.86A 4tvtA-5h8wA:
undetectable		 4tvtA-5h8wA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ARG A  35
GLN A  42
GLU A  45
 None
 0.76A 4tvtA-5i1wA:
undetectable		 4tvtA-5i1wA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		3 ARG A 227
GLN A 451
GLU A 449
 None
 0.93A 4tvtA-5j90A:
undetectable		 4tvtA-5j90A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l08 CASPASE-8

(Homo sapiens) 		PF01335
(DED) 		3 ARG A 162
GLN A 166
GLU A 126
 None
 0.93A 4tvtA-5l08A:
undetectable		 4tvtA-5l08A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 3 ARG A 223
GLN A 214
GLU A 210
 None
 0.93A 4tvtA-5n2gA:
undetectable		 4tvtA-5n2gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 3 ARG A 755
GLN A 688
GLU A 686
 None
 0.81A 4tvtA-5n8dA:
undetectable		 4tvtA-5n8dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8x SOLUBLE LYTIC
TRANSGLYCOSYLASE B

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A  54
GLN A  57
GLU A  60
 None
 0.89A 4tvtA-5o8xA:
undetectable		 4tvtA-5o8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		3 ARG B 666
GLN B 662
GLU B 235
 None
 0.79A 4tvtA-5of4B:
undetectable		 4tvtA-5of4B:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		3 ARG A1196
GLN A1103
GLU A1200
 None
 0.82A 4tvtA-5t03A:
undetectable		 4tvtA-5t03A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 3 ARG A 616
GLN A 618
GLU A 819
 G  B   8 ( 4.8A)
G  B   8 ( 3.5A)
G  B   8 ( 3.3A)
 0.75A 4tvtA-5u30A:
undetectable		 4tvtA-5u30A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 3 ARG A1103
GLN A1102
GLU A 968
 None
 0.91A 4tvtA-5u30A:
undetectable		 4tvtA-5u30A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3k DH511.2 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 3 ARG L 142
GLN L 166
GLU L 165
 None
 0.91A 4tvtA-5u3kL:
undetectable		 4tvtA-5u3kL:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 ARG A 330
GLN A 274
GLU A 454
 None
 0.93A 4tvtA-5ux5A:
undetectable		 4tvtA-5ux5A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwz RNA-BINDING E3
UBIQUITIN-PROTEIN
LIGASE MEX3C

(Homo sapiens) 		no annotation 3 ARG B 332
GLN B 330
GLU B 368
 None
 0.90A 4tvtA-5wwzB:
undetectable		 4tvtA-5wwzB:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		3 ARG A 700
GLN A 696
GLU A 376
 None
 0.87A 4tvtA-5xapA:
undetectable		 4tvtA-5xapA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		3 ARG A2848
GLN A2852
GLU A2822
 None
 0.79A 4tvtA-5xauA:
undetectable		 4tvtA-5xauA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
SMALL SUBUNIT
ALDEHYDE OXIDASE
MEDIUM SUBUNIT

(Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400) 		no annotation
no annotation 		3 ARG B 103
GLN B  96
GLU A 131
 GOL  B 406 (-4.1A)
None
None
 0.93A 4tvtA-5y6qB:
undetectable		 4tvtA-5y6qB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		no annotation 3 ARG A 175
GLN A 174
GLU A 178
 None
 0.87A 4tvtA-5yt0A:
undetectable		 4tvtA-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 3 ARG B 951
GLN B 952
GLU B 948
 None
 0.93A 4tvtA-6btmB:
undetectable		 4tvtA-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6y JC57-14 LIGHT CHAIN

(Macaca mulatta) 		no annotation 3 ARG B 142
GLN B 166
GLU B 165
 None
 0.86A 4tvtA-6c6yB:
undetectable		 4tvtA-6c6yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgb CADHERIN-11,
CADHERIN-6 CHIMERA

(Mus musculus) 		no annotation 3 ARG A  68
GLN A  70
GLU A  42
 None
 0.75A 4tvtA-6cgbA:
undetectable		 4tvtA-6cgbA:
undetectable