SIMILAR PATTERNS OF AMINO ACIDS FOR 4TVT_A_ASCA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7o IGG1-KAPPA D1.3 FV
(LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		3 THR L  18
ASN L  76
SER L  77
 None
 0.67A 4tvtA-1a7oL:
1.1		 4tvtA-1a7oL:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf7 PROTEIN
(TRANSCRIPTION
FACTOR DP-2)

(Homo sapiens) 		PF02319
(E2F_TDP) 		3 THR B 102
ASN B 103
SER B 104
 None
 0.77A 4tvtA-1cf7B:
undetectable		 4tvtA-1cf7B:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp7 MHC CLASS II
TRANSCRIPTION FACTOR
HRFX1

(Homo sapiens) 		PF02257
(RFX_DNA_binding) 		3 THR P  61
ASN P  64
SER P  65
 None
 0.75A 4tvtA-1dp7P:
undetectable		 4tvtA-1dp7P:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 3 THR B1212
ASN B1213
SER B1214
 None
 0.78A 4tvtA-1ej6B:
0.0		 4tvtA-1ej6B:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6l ANTI-FERRITIN
IMMUNOGLOBULIN LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 THR L  18
ASN L  76
SER L  77
 None
 0.74A 4tvtA-1f6lL:
0.0		 4tvtA-1f6lL:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq8 PECTINESTERASE

(Daucus carota) 		PF01095
(Pectinesterase) 		3 THR A  82
ASN A  85
SER A  86
 None
 0.51A 4tvtA-1gq8A:
0.0		 4tvtA-1gq8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ind IGG1-LAMBDA CHA255
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR H 132
ASN H 133
SER H 134
 None
 0.76A 4tvtA-1indH:
0.0		 4tvtA-1indH:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		3 THR A 492
ASN A 495
SER A 496
 None
 0.69A 4tvtA-1jmyA:
0.0		 4tvtA-1jmyA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		3 THR A 105
ASN A 104
SER A 128
 None
 0.77A 4tvtA-1k32A:
0.0		 4tvtA-1k32A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kec PENICILLIN ACYLASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01804
(Penicil_amidase) 		3 THR A 208
ASN A 205
SER A 206
 None
 0.78A 4tvtA-1kecA:
undetectable		 4tvtA-1kecA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 THR A 269
ASN A 272
SER A 273
 None
 0.74A 4tvtA-1orrA:
undetectable		 4tvtA-1orrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 THR A 264
ASN A 189
SER A 190
 None
SO4  A 507 (-3.1A)
None
 0.63A 4tvtA-1pgjA:
undetectable		 4tvtA-1pgjA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qa4 PROTEIN (HIV-1 NEF
ANCHOR DOMAIN
(2-57))

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		3 THR A  44
ASN A  47
SER A  46
 None
 0.63A 4tvtA-1qa4A:
undetectable		 4tvtA-1qa4A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qag UTROPHIN ACTIN
BINDING REGION

(Homo sapiens) 		PF00307
(CH) 		3 THR A 150
ASN A 151
SER A 152
 None
 0.71A 4tvtA-1qagA:
undetectable		 4tvtA-1qagA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		3 THR A 262
ASN A 231
SER A 260
 None
 0.73A 4tvtA-1wraA:
undetectable		 4tvtA-1wraA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 THR A 790
ASN A 766
SER A 765
 None
 0.74A 4tvtA-1xf1A:
undetectable		 4tvtA-1xf1A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS

(Escherichia
coli) 		PF05307
(Bundlin) 		3 THR A  57
ASN A  58
SER A 149
 None
 0.76A 4tvtA-1zwtA:
undetectable		 4tvtA-1zwtA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgz WERNER SYNDROME
PROTEIN VARIANT

(Homo sapiens) 		PF00570
(HRDC) 		3 THR A1225
ASN A1226
SER A1227
 None
 0.55A 4tvtA-2dgzA:
undetectable		 4tvtA-2dgzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		3 THR A 692
ASN A 695
SER A 696
 None
 0.65A 4tvtA-2eaeA:
undetectable		 4tvtA-2eaeA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkk BASEPLATE STRUCTURAL
PROTEIN GP10

(Escherichia
virus T4) 		no annotation 3 THR A 576
ASN A 577
SER A 578
 PO3  A 710 ( 4.1A)
None
None
 0.63A 4tvtA-2fkkA:
undetectable		 4tvtA-2fkkA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g64 PUTATIVE 6-PYRUVOYL
TETRAHYDROBIOPTERIN
SYNTHASE

(Caenorhabditis
elegans) 		PF01242
(PTPS) 		3 THR A  97
ASN A 103
SER A  99
 None
 0.76A 4tvtA-2g64A:
undetectable		 4tvtA-2g64A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		3 THR A   5
ASN A 230
SER A 229
 None
 0.70A 4tvtA-2jfwA:
undetectable		 4tvtA-2jfwA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzw UNCHARACTERIZED
PROTEIN

(Methanosarcina
mazei) 		PF00801
(PKD)
PF05048
(NosD) 		3 THR A  89
ASN A 124
SER A 123
 None
 0.67A 4tvtA-2kzwA:
undetectable		 4tvtA-2kzwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l2n HYPONASTIC LEAVE 1

(Arabidopsis
thaliana) 		PF00035
(dsrm) 		3 THR A  50
ASN A  59
SER A  60
 None
 0.61A 4tvtA-2l2nA:
undetectable		 4tvtA-2l2nA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxc UBIQUITIN-LIKE
PROTEIN MDY2

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin) 		3 THR A 138
ASN A 141
SER A 142
 None
 0.65A 4tvtA-2lxcA:
undetectable		 4tvtA-2lxcA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myh OMEGA-TBO-IT1 TOXIN

(Tibellus
oblongus) 		no annotation 3 THR A  29
ASN A  36
SER A  37
 None
 0.70A 4tvtA-2myhA:
undetectable		 4tvtA-2myhA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1

(Homo sapiens) 		PF13238
(AAA_18) 		3 THR A  12
ASN A  13
SER A  14
 TIZ  A 302 ( 4.2A)
ADP  A 301 ( 4.1A)
ADP  A 301 ( 3.4A)
 0.76A 4tvtA-2ql6A:
undetectable		 4tvtA-2ql6A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF13599
(Pentapeptide_4) 		3 THR A 183
ASN A 163
SER A 162
 None
 0.75A 4tvtA-2w7zA:
undetectable		 4tvtA-2w7zA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 3 THR A 346
ASN A 379
SER A 380
 None
 0.64A 4tvtA-2x3hA:
undetectable		 4tvtA-2x3hA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 THR A 506
ASN A 514
SER A 515
 None
 0.74A 4tvtA-2ycbA:
undetectable		 4tvtA-2ycbA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuc DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Sulfolobus
solfataricus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		3 THR A 213
ASN A 255
SER A 211
 None
 0.73A 4tvtA-2zucA:
undetectable		 4tvtA-2zucA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE

(Photobacterium
phosphoreum) 		PF11477
(PM0188) 		3 THR A 304
ASN A 305
SER A 306
 None
 0.77A 4tvtA-2zwiA:
undetectable		 4tvtA-2zwiA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adg F21M12.9 PROTEIN

(Arabidopsis
thaliana) 		PF00035
(dsrm) 		3 THR A  50
ASN A  59
SER A  60
 None
 0.68A 4tvtA-3adgA:
undetectable		 4tvtA-3adgA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 THR A 223
ASN A 224
SER A 225
 None
 0.76A 4tvtA-3afeA:
undetectable		 4tvtA-3afeA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcw UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF05899
(Cupin_3) 		3 THR A 103
ASN A  63
SER A  62
 None
None
ACT  A 123 (-2.7A)
 0.54A 4tvtA-3bcwA:
undetectable		 4tvtA-3bcwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 THR A 185
ASN A 219
SER A 218
 MPD  A 801 ( 3.8A)
MPD  A 801 ( 3.9A)
None
 0.69A 4tvtA-3cmgA:
undetectable		 4tvtA-3cmgA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y ML43
ML50

(Homo sapiens;
Homo sapiens) 		no annotation
PF01281
(Ribosomal_L9_N) 		3 THR h 155
ASN b  66
SER b  67
 None
 0.70A 4tvtA-3j7yh:
undetectable		 4tvtA-3j7yh:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksc LEGA CLASS

(Pisum sativum) 		PF00190
(Cupin_1) 		3 THR A 437
ASN A 380
SER A 381
 None
 0.74A 4tvtA-3kscA:
undetectable		 4tvtA-3kscA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odn DALLY-LIKE PROTEIN

(Drosophila
melanogaster) 		PF01153
(Glypican) 		3 THR A 567
ASN A 573
SER A 572
 None
 0.73A 4tvtA-3odnA:
undetectable		 4tvtA-3odnA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia pestis) 		PF04095
(NAPRTase) 		3 THR A 233
ASN A 236
SER A 237
 None
 0.50A 4tvtA-3os4A:
undetectable		 4tvtA-3os4A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0s CAPSID PROTEIN VP

(Lepidopteran
iteradensovirus
1) 		PF01057
(Parvo_NS1) 		3 THR A  86
ASN A  87
SER A  88
 None
 0.77A 4tvtA-3p0sA:
undetectable		 4tvtA-3p0sA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8k HYDROLASE,
CARBON-NITROGEN
FAMILY

(Staphylococcus
aureus) 		PF00795
(CN_hydrolase) 		3 THR A  94
ASN A  85
SER A  84
 None
CL  A 271 (-3.7A)
None
 0.76A 4tvtA-3p8kA:
undetectable		 4tvtA-3p8kA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		3 THR A  71
ASN A 245
SER A 235
 None
 0.76A 4tvtA-3qhyA:
undetectable		 4tvtA-3qhyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4r HYPOTHETICAL
FIMBRIAL ASSEMBLY
PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		3 THR A 140
ASN A 147
SER A 148
 None
 0.69A 4tvtA-3r4rA:
undetectable		 4tvtA-3r4rA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkd MONOCLONAL ANTIBODY,
LIGHT CHAIN

(Mus musculus) 		no annotation 3 THR L  18
ASN L  76
SER L  77
 None
 0.48A 4tvtA-3rkdL:
undetectable		 4tvtA-3rkdL:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tjr SHORT CHAIN
DEHYDROGENASE

(Mycobacterium
avium) 		PF00106
(adh_short) 		3 THR A 145
ASN A  94
SER A  93
 UNL  A 281 ( 3.8A)
UNL  A 281 ( 3.3A)
None
 0.37A 4tvtA-3tjrA:
undetectable		 4tvtA-3tjrA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3win HA3

(Clostridium
botulinum) 		PF03505
(Clenterotox) 		3 THR E 625
ASN E 554
SER E 553
 None
 0.78A 4tvtA-3winE:
undetectable		 4tvtA-3winE:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bil DNA MATURASE B

(Escherichia
virus T7) 		no annotation 3 THR A 170
ASN A 167
SER A 168
 None
 0.78A 4tvtA-4bilA:
undetectable		 4tvtA-4bilA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		3 THR A 248
ASN A 278
SER A 279
 NAG  A 411 ( 4.0A)
NAG  A 411 (-1.8A)
None
 0.69A 4tvtA-4c2lA:
undetectable		 4tvtA-4c2lA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		3 THR A 567
ASN A 534
SER A 535
 None
 0.74A 4tvtA-4c4vA:
undetectable		 4tvtA-4c4vA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgn GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Leishmania
major) 		PF01233
(NMT)
PF02799
(NMT_C) 		3 THR A 331
ASN A  91
SER A 330
 None
None
7AH  A1000 (-3.0A)
 0.77A 4tvtA-4cgnA:
undetectable		 4tvtA-4cgnA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		3 THR A 236
ASN A 266
SER A 265
 CSO  A 211 ( 4.3A)
None
None
 0.73A 4tvtA-4cyfA:
undetectable		 4tvtA-4cyfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		3 THR A 501
ASN A 502
SER A 503
 None
 0.77A 4tvtA-4czwA:
undetectable		 4tvtA-4czwA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eln TYPE III EFFECTOR
XOPAI

(Xanthomonas
citri) 		PF01129
(ART) 		3 THR A 199
ASN A 247
SER A 248
 None
 0.70A 4tvtA-4elnA:
undetectable		 4tvtA-4elnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		3 THR A 485
ASN A 486
SER A 487
 None
 0.76A 4tvtA-4fajA:
undetectable		 4tvtA-4fajA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmr UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
vulgatus) 		PF14734
(DUF4469)
PF14848
(HU-DNA_bdg) 		3 THR A  99
ASN A 100
SER A 101
 None
 0.74A 4tvtA-4fmrA:
undetectable		 4tvtA-4fmrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 3 THR A 187
ASN A 205
SER A 206
 None
 0.66A 4tvtA-4gk9A:
undetectable		 4tvtA-4gk9A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzi GLUCAN
ENDO-1,3-BETA-D-GLUC
OSIDASE

(Solanum
tuberosum) 		PF00332
(Glyco_hydro_17) 		3 THR A 164
ASN A 165
SER A 172
 None
 0.66A 4tvtA-4gziA:
undetectable		 4tvtA-4gziA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		3 THR A 216
ASN A 220
SER A 219
 None
 0.74A 4tvtA-4io1A:
undetectable		 4tvtA-4io1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kly BLUE-LIGHT ABSORBING
PROTEORHODOPSIN

(gamma
proteobacterium
'Hot 75m4') 		PF01036
(Bac_rhodopsin) 		3 THR A 177
ASN A 183
SER A 179
 None
 0.74A 4tvtA-4klyA:
undetectable		 4tvtA-4klyA:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l2j OSMOTIN: ANTIFUNGAL
LATICIFER PROTEIN

(Calotropis
procera) 		PF00314
(Thaumatin) 		3 THR A  13
ASN A  27
SER A  28
 None
 0.14A 4tvtA-4l2jA:
34.0		 4tvtA-4l2jA:
59.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		3 THR A 212
ASN A 234
SER A 233
 None
 0.56A 4tvtA-4mp3A:
undetectable		 4tvtA-4mp3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nps BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		PF02661
(Fic) 		3 THR A 209
ASN A 215
SER A 214
 None
 0.68A 4tvtA-4npsA:
undetectable		 4tvtA-4npsA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 THR A 580
ASN A 340
SER A 341
 None
 0.54A 4tvtA-4nreA:
undetectable		 4tvtA-4nreA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6v OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella suis) 		PF13561
(adh_short_C2) 		3 THR A  10
ASN A  81
SER A  82
 None
 0.69A 4tvtA-4o6vA:
undetectable		 4tvtA-4o6vA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oro POLYMERASE PB2

(Influenza B
virus) 		PF00604
(Flu_PB2) 		3 THR A 482
ASN A 389
SER A 390
 None
 0.61A 4tvtA-4oroA:
undetectable		 4tvtA-4oroA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		3 THR A 180
ASN A 161
SER A 162
 None
None
289  A 421 ( 1.3A)
 0.59A 4tvtA-4q1qA:
undetectable		 4tvtA-4q1qA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		3 THR A 161
ASN A 164
SER A 165
 None
None
XA2  A 407 ( 4.4A)
 0.70A 4tvtA-4q3rA:
undetectable		 4tvtA-4q3rA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1

(Saccharomyces
cerevisiae) 		PF02127
(Peptidase_M18) 		3 THR A 301
ASN A 294
SER A 299
 None
 0.72A 4tvtA-4r8fA:
undetectable		 4tvtA-4r8fA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92) 		no annotation 3 THR A 768
ASN A 769
SER A 770
 None
 0.72A 4tvtA-4rmxA:
undetectable		 4tvtA-4rmxA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsw HOPA1

(Pseudomonas
syringae) 		no annotation 3 THR A 259
ASN A 281
SER A 257
 None
 0.68A 4tvtA-4rswA:
undetectable		 4tvtA-4rswA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xae FERULOYL COA
ORTHO-HYDROXYLASE 1

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		3 THR A 123
ASN A 126
SER A 127
 None
 0.76A 4tvtA-4xaeA:
undetectable		 4tvtA-4xaeA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		3 THR A 389
ASN A 408
SER A 409
 None
 0.70A 4tvtA-4xgjA:
undetectable		 4tvtA-4xgjA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue S4B6 FAB LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 THR L  55
ASN L  34
SER L  53
 None
 0.78A 4tvtA-4yueL:
undetectable		 4tvtA-4yueL:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 3 THR A 241
ASN A 244
SER A 245
 None
 0.70A 4tvtA-4zyoA:
undetectable		 4tvtA-4zyoA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5amz THAUMATIN-1

(Thaumatococcus
daniellii) 		PF00314
(Thaumatin) 		3 THR A  12
ASN A  32
SER A  33
 None
 0.06A 4tvtA-5amzA:
40.9		 4tvtA-5amzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqy HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 THR B 156
ASN B 154
SER B 151
 NAG  B 301 (-3.6A)
NAG  B 301 (-1.9A)
None
 0.75A 4tvtA-5bqyB:
undetectable		 4tvtA-5bqyB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE

(Penicillium
cyclopium) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		3 THR A  72
ASN A  73
SER A  74
 None
CL  A 303 (-3.1A)
None
 0.71A 4tvtA-5ch8A:
undetectable		 4tvtA-5ch8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		3 THR B  52
ASN B  84
SER B  50
 None
 0.73A 4tvtA-5d9aB:
undetectable		 4tvtA-5d9aB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfw SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 THR H 518
ASN H 722
SER H 723
 None
 0.51A 4tvtA-5dfwH:
undetectable		 4tvtA-5dfwH:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 THR A 384
ASN A 387
SER A 386
 None
 0.72A 4tvtA-5djwA:
undetectable		 4tvtA-5djwA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 THR A 639
ASN A 621
SER A 622
 None
None
C8E  A1731 (-3.2A)
 0.68A 4tvtA-5fr8A:
undetectable		 4tvtA-5fr8A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 3 THR I 807
ASN I 804
SER I 805
 None
 0.73A 4tvtA-5furI:
undetectable		 4tvtA-5furI:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 THR A 529
ASN A 530
SER A 531
 None
 0.75A 4tvtA-5h1kA:
undetectable		 4tvtA-5h1kA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 3 THR A 473
ASN A 622
SER A 621
 None
 0.74A 4tvtA-5h7jA:
undetectable		 4tvtA-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8k N-CARBAMOYLPUTRESCIN
E AMIDOHYDROLASE

(Medicago
truncatula) 		PF00795
(CN_hydrolase) 		3 THR A 182
ASN A 218
SER A 217
 None
 0.77A 4tvtA-5h8kA:
undetectable		 4tvtA-5h8kA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 LIPOPOLYSACCHARIDE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
LPTB

(Klebsiella
pneumoniae) 		PF00005
(ABC_tran)
PF12399
(BCA_ABC_TP_C) 		3 THR A   3
ASN A  27
SER A  28
 None
 0.77A 4tvtA-5l75A:
undetectable		 4tvtA-5l75A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 THR H 157
ASN H 215
SER H 216
 None
 0.56A 4tvtA-5lx9H:
undetectable		 4tvtA-5lx9H:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 3 THR A 247
ASN A 393
SER A 394
 None
 0.73A 4tvtA-5m3xA:
undetectable		 4tvtA-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 3 THR A 629
ASN A 611
SER A 612
 None
 0.70A 4tvtA-5mzsA:
undetectable		 4tvtA-5mzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n05 AUXILIARY ACTIVITY 9

(Lentinus
similis) 		PF03443
(Glyco_hydro_61) 		3 THR A 109
ASN A 110
SER A 111
 None
 0.73A 4tvtA-5n05A:
undetectable		 4tvtA-5n05A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		3 THR A 311
ASN A 229
SER A 230
 None
 0.71A 4tvtA-5o0sA:
undetectable		 4tvtA-5o0sA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Homo sapiens) 		PF01663
(Phosphodiest) 		3 THR A  65
ASN A 369
SER A 370
 None
NAG  A 506 (-1.8A)
None
 0.67A 4tvtA-5vemA:
undetectable		 4tvtA-5vemA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veo ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5

(Mus musculus) 		PF01663
(Phosphodiest) 		3 THR A  65
ASN A 369
SER A 370
 EDO  A 518 (-3.7A)
NAG  A 509 ( 1.9A)
EDO  A 518 (-2.8A)
 0.70A 4tvtA-5veoA:
undetectable		 4tvtA-5veoA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 THR A 293
ASN A 311
SER A 312
 None
 0.77A 4tvtA-5w7zA:
undetectable		 4tvtA-5w7zA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r PROTEIN CS22

(Spinacia
oleracea) 		no annotation 3 THR v 156
ASN v 163
SER v 162
 None
 0.75A 4tvtA-5x8rv:
undetectable		 4tvtA-5x8rv:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccb GLYCOPROTEIN 41

(Human
immunodeficiency
virus 1) 		no annotation 3 THR A 612
ASN A 616
SER A 615
 None
 0.63A 4tvtA-6ccbA:
undetectable		 4tvtA-6ccbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 3 THR B 160
ASN B 178
SER B 161
 None
 0.78A 4tvtA-6emkB:
undetectable		 4tvtA-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 3 THR A1749
ASN A1765
SER A1766
 None
 0.76A 4tvtA-6fb3A:
undetectable		 4tvtA-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6geb DOTB

(Legionella
pneumophila) 		no annotation 3 THR A  40
ASN A  62
SER A  61
 None
 0.70A 4tvtA-6gebA:
undetectable		 4tvtA-6gebA:
undetectable