SIMILAR PATTERNS OF AMINO ACIDS FOR 4S0V_A_SUVA2001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		4 ILE A  80
PRO A  81
TYR A 144
VAL A 148
 None
 1.24A 4s0vA-1edgA:
undetectable		 4s0vA-1edgA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 198
HIS A 247
TYR A 308
VAL A 312
 None
 0.89A 4s0vA-1j0hA:
undetectable		 4s0vA-1j0hA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 195
HIS A 244
TYR A 306
VAL A 310
 None
 0.98A 4s0vA-1jf5A:
undetectable		 4s0vA-1jf5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 212
HIS A 244
TYR A 306
VAL A 310
 None
 1.20A 4s0vA-1jf5A:
undetectable		 4s0vA-1jf5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lme PEPTIDE DEFORMYLASE

(Thermotoga
maritima) 		PF01327
(Pep_deformylase) 		4 ILE A  34
PRO A  65
TYR A 122
VAL A 126
 None
 1.24A 4s0vA-1lmeA:
undetectable		 4s0vA-1lmeA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Chlamydomonas
reinhardtii) 		PF00033
(Cytochrome_B)
PF00355
(Rieske) 		4 ILE B 165
PRO B 155
HIS C 155
VAL B 175
 TDS  D 920 ( 4.7A)
TDS  D 920 ( 4.7A)
FES  C 210 ( 3.0A)
None
 1.35A 4s0vA-1q90B:
6.0		 4s0vA-1q90B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 ILE A 375
HIS A 277
TYR A 273
VAL A 345
 None
ZN  A 387 (-3.3A)
None
None
 1.14A 4s0vA-1rrmA:
2.5		 4s0vA-1rrmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 198
HIS A 247
TYR A 308
VAL A 312
 None
 0.89A 4s0vA-1smaA:
undetectable		 4s0vA-1smaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbc POLIOVIRUS TYPE 3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3  49
HIS 3 230
TYR 3 107
VAL 3 222
 None
 1.29A 4s0vA-1vbc3:
undetectable		 4s0vA-1vbc3:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		4 ILE A  46
PRO A  47
TYR A 155
VAL A  15
 None
 1.34A 4s0vA-1vzvA:
undetectable		 4s0vA-1vzvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3  49
HIS 3 229
TYR 3 106
VAL 3 221
 None
 1.29A 4s0vA-1z7z3:
undetectable		 4s0vA-1z7z3:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 ILE A  67
PRO A  65
HIS A  81
VAL A  91
 None
 1.30A 4s0vA-2dfsA:
undetectable		 4s0vA-2dfsA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ILE A 274
PRO A 273
TYR A 309
VAL A 285
 None
 1.12A 4s0vA-2ebdA:
undetectable		 4s0vA-2ebdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ILE A 312
PRO A 313
HIS A 259
TYR A 601
 None
 1.30A 4s0vA-2fjaA:
3.3		 4s0vA-2fjaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 PRO A 132
HIS A 368
TYR A 277
VAL A 258
 None
 1.34A 4s0vA-2gmhA:
4.4		 4s0vA-2gmhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 PRO A 362
HIS A 368
TYR A 277
VAL A 258
 None
 1.14A 4s0vA-2gmhA:
4.4		 4s0vA-2gmhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		4 ILE A 267
PRO A 288
TYR A 254
VAL A 258
 None
 1.33A 4s0vA-2h1yA:
3.4		 4s0vA-2h1yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 ILE A 115
HIS A 155
TYR A  39
VAL A  91
 None
 1.35A 4s0vA-2iu4A:
undetectable		 4s0vA-2iu4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 ILE X  66
HIS X 120
TYR X 370
VAL X 413
 None
 1.34A 4s0vA-2jfeX:
undetectable		 4s0vA-2jfeX:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 138
PRO A  32
TYR A 185
VAL A 152
 None
 1.30A 4s0vA-2nz9A:
undetectable		 4s0vA-2nz9A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		4 ILE A 444
PRO A 443
HIS A 491
VAL A 419
 None
 1.32A 4s0vA-2oudA:
undetectable		 4s0vA-2oudA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A1298
PRO A1297
HIS A1239
TYR A1706
 None
 1.30A 4s0vA-2pffA:
5.1		 4s0vA-2pffA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psm INTERLEUKIN-15
RECEPTOR ALPHA CHAIN

(Mus musculus) 		no annotation 4 ILE F  10
HIS F  56
TYR F  20
VAL F  17
 None
 1.05A 4s0vA-2psmF:
undetectable		 4s0vA-2psmF:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 ILE A  61
PRO A  31
HIS A 245
VAL A  77
 None
FMN  A7401 (-4.3A)
None
None
 1.35A 4s0vA-2q3oA:
undetectable		 4s0vA-2q3oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		4 ILE A 278
HIS A 186
TYR A 207
VAL A 234
 None
 1.23A 4s0vA-2ragA:
undetectable		 4s0vA-2ragA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 ILE A  55
PRO B 304
TYR A  93
VAL A  60
 None
 1.34A 4s0vA-2xfbA:
undetectable		 4s0vA-2xfbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 217
PRO A 185
TYR A 233
VAL A 213
 None
 0.86A 4s0vA-2yp2A:
undetectable		 4s0vA-2yp2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		4 ILE A 240
PRO A 262
HIS A 346
VAL A 196
 None
 1.33A 4s0vA-3ax6A:
3.1		 4s0vA-3ax6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 ILE A 379
HIS A 281
TYR A 277
VAL A 349
 None
FE2  A1388 (-3.6A)
None
None
 1.10A 4s0vA-3bfjA:
2.7		 4s0vA-3bfjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 ILE A 382
HIS A 281
TYR A 277
VAL A 349
 None
FE2  A1388 (-3.6A)
None
None
 1.08A 4s0vA-3bfjA:
2.7		 4s0vA-3bfjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		4 ILE A 535
PRO A 530
HIS A 525
VAL A 142
 None
 1.33A 4s0vA-3biwA:
undetectable		 4s0vA-3biwA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ILE A 342
PRO A 341
HIS A 356
VAL A 321
 None
None
None
UDP  A 600 ( 3.9A)
 1.04A 4s0vA-3c4qA:
22.9		 4s0vA-3c4qA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ILE A 210
PRO A 325
HIS A 248
VAL A 305
 None
 1.23A 4s0vA-3cp8A:
undetectable		 4s0vA-3cp8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		4 ILE A  45
HIS A 276
TYR A  22
VAL A  31
 None
 1.20A 4s0vA-3dhuA:
undetectable		 4s0vA-3dhuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 ILE A 470
HIS A 357
TYR A 420
VAL A 425
 None
 1.28A 4s0vA-3fdhA:
undetectable		 4s0vA-3fdhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE A 352
HIS A 213
TYR A 129
VAL A 143
 None
NAG  A 383 (-3.8A)
None
None
 1.14A 4s0vA-3hsyA:
5.2		 4s0vA-3hsyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 ILE A 423
HIS A 332
TYR A 212
VAL A 342
 None
M44  A 518 (-3.7A)
M44  A 518 (-3.6A)
None
 1.36A 4s0vA-3l7gA:
undetectable		 4s0vA-3l7gA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 163
PRO A 193
HIS A 234
VAL A 201
 None
 1.31A 4s0vA-3mwcA:
undetectable		 4s0vA-3mwcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		4 ILE A  97
HIS A 175
TYR A 196
VAL A 167
 None
 1.26A 4s0vA-3vmwA:
undetectable		 4s0vA-3vmwA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 348
HIS A 184
TYR A 197
VAL A 249
 None
FAD  A 607 (-3.8A)
None
None
 1.20A 4s0vA-3vteA:
undetectable		 4s0vA-3vteA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl4 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02585
(PIG-L) 		4 ILE A  35
HIS A 151
TYR A 109
VAL A 120
 None
CD  A 301 ( 3.5A)
None
None
 1.27A 4s0vA-3wl4A:
2.1		 4s0vA-3wl4A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxm PROTEIN PELOTA
HOMOLOG

(Aeropyrum
pernix) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 ILE B 250
PRO B 326
HIS B 298
VAL B 322
 None
 1.33A 4s0vA-3wxmB:
undetectable		 4s0vA-3wxmB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c25 L-FUCULOSE PHOSPHATE
ALDOLASE

(Streptococcus
pneumoniae) 		PF00596
(Aldolase_II) 		4 ILE A  45
PRO A  42
HIS A  78
TYR A 131
 None
 1.28A 4s0vA-4c25A:
undetectable		 4s0vA-4c25A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 ILE B  31
PRO B  30
HIS B 194
TYR B  22
 None
 1.27A 4s0vA-4ccyB:
2.6		 4s0vA-4ccyB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ILE A 198
PRO A 199
TYR A 168
VAL A 172
 None
None
TRS  A 401 (-4.5A)
None
 0.96A 4s0vA-4d9iA:
undetectable		 4s0vA-4d9iA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 143
HIS A 157
TYR A 228
VAL A 213
 None
 1.36A 4s0vA-4d9rA:
undetectable		 4s0vA-4d9rA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ILE A 539
PRO A 536
HIS A 522
VAL A 202
 None
 1.28A 4s0vA-4di5A:
undetectable		 4s0vA-4di5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 330
PRO A 327
HIS A 225
TYR A 247
 None
GOL  A 502 (-4.5A)
GOL  A 502 (-4.4A)
None
 1.09A 4s0vA-4ihcA:
undetectable		 4s0vA-4ihcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhy HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF14730
(DUF4468) 		4 ILE A 153
PRO A 156
TYR A  38
VAL A  36
 None
 1.13A 4s0vA-4jhyA:
undetectable		 4s0vA-4jhyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpz FIBROBLAST GROWTH
FACTOR 13
SODIUM CHANNEL
PROTEIN TYPE 2
SUBUNIT ALPHA

(Homo sapiens) 		PF00167
(FGF)
PF00612
(IQ)
PF16905
(GPHH) 		4 ILE A  52
PRO A  53
HIS B1853
VAL A 100
 None
 1.27A 4s0vA-4jpzA:
undetectable		 4s0vA-4jpzA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0v EXONUCLEASE SUBUNIT
SBCD

(Escherichia
coli) 		PF00149
(Metallophos)
PF12320
(SbcD_C) 		4 ILE A 242
PRO A 241
HIS A   5
VAL A 196
 None
 1.28A 4s0vA-4m0vA:
undetectable		 4s0vA-4m0vA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 PRO A 239
HIS A 452
TYR A 477
VAL A 475
 None
 1.30A 4s0vA-4mifA:
2.6		 4s0vA-4mifA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 ILE A 309
PRO A 310
HIS A 206
VAL A 189
 None
 1.36A 4s0vA-4nfuA:
undetectable		 4s0vA-4nfuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 479
PRO A 480
HIS A 401
VAL A 310
 None
 1.27A 4s0vA-4nkyA:
undetectable		 4s0vA-4nkyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 ILE A 277
PRO A  12
TYR A  26
VAL A  25
 None
 1.36A 4s0vA-4oyaA:
undetectable		 4s0vA-4oyaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE A 432
PRO A 428
TYR A 650
VAL A 649
 None
 1.09A 4s0vA-4pj3A:
undetectable		 4s0vA-4pj3A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1z PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF16215
(DUF4876) 		4 ILE A 253
HIS A 204
TYR A 339
VAL A 260
 None
 1.28A 4s0vA-4q1zA:
undetectable		 4s0vA-4q1zA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3  49
HIS 3 229
TYR 3 106
VAL 3 221
 None
 1.24A 4s0vA-4q4y3:
undetectable		 4s0vA-4q4y3:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnw CHANOCLAVINE-I
ALDEHYDE REDUCTASE

(Aspergillus
fumigatus) 		PF00724
(Oxidored_FMN) 		4 ILE A  61
PRO A  29
TYR A 359
VAL A  45
 None
FMN  A 401 (-3.7A)
None
None
 1.31A 4s0vA-4qnwA:
undetectable		 4s0vA-4qnwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ILE A 212
PRO A 213
TYR A 186
VAL A 192
 None
 1.30A 4s0vA-4uzsA:
3.8		 4s0vA-4uzsA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4we6 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 177
PRO A 145
TYR A 193
VAL A 173
 None
 0.90A 4s0vA-4we6A:
undetectable		 4s0vA-4we6A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg)
PF14533
(USP7_C2) 		4 ILE A 949
PRO A1006
HIS A1081
VAL A1043
 None
 1.32A 4s0vA-4z96A:
undetectable		 4s0vA-4z96A:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 ILE A 122
PRO A 123
HIS A 216
TYR A 311
VAL A 347
 SUV  A2001 ( 4.8A)
SUV  A2001 (-3.9A)
SUV  A2001 ( 4.8A)
None
SUV  A2001 ( 4.6A)
 0.34A 4s0vA-4zj8A:
46.2		 4s0vA-4zj8A:
83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 ILE A  89
HIS A 140
TYR A 193
VAL A 197
 None
ACT  A1479 (-4.4A)
None
None
 0.98A 4s0vA-5a2aA:
undetectable		 4s0vA-5a2aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 ILE A 381
PRO A 305
HIS A 299
VAL A 226
 None
 1.34A 4s0vA-5djqA:
3.0		 4s0vA-5djqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e55 CONTACTIN-6

(Mus musculus) 		PF00041
(fn3) 		4 ILE A 724
PRO A 725
TYR A 671
VAL A 669
 None
 1.33A 4s0vA-5e55A:
undetectable		 4s0vA-5e55A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A  54
PRO A  55
HIS A 169
VAL A 208
 GSH  A 301 (-4.2A)
GSH  A 301 ( 4.8A)
None
None
 1.33A 4s0vA-5f06A:
undetectable		 4s0vA-5f06A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 ILE A 348
PRO A 309
TYR A 268
VAL A 315
 None
 1.16A 4s0vA-5f0oA:
undetectable		 4s0vA-5f0oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		4 ILE A  32
HIS A 145
TYR A 234
VAL A 263
 None
ZN  A 403 ( 3.3A)
None
None
 1.21A 4s0vA-5fbbA:
undetectable		 4s0vA-5fbbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		4 ILE A  42
HIS A 356
TYR A 300
VAL A 304
 None
 1.34A 4s0vA-5fqlA:
undetectable		 4s0vA-5fqlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 ILE A  92
PRO A  93
HIS A 123
TYR A 105
 None
 1.24A 4s0vA-5fv4A:
undetectable		 4s0vA-5fv4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 ILE A 325
PRO A 326
HIS A 393
VAL A 307
 None
 1.25A 4s0vA-5gweA:
undetectable		 4s0vA-5gweA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 ILE A  22
PRO A  21
HIS A 179
TYR A  96
 None
None
VDM  A 502 (-3.6A)
None
 1.26A 4s0vA-5hvoA:
6.4		 4s0vA-5hvoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 PRO A 641
HIS A 553
TYR A 647
VAL A 653
 None
 1.31A 4s0vA-5jbgA:
undetectable		 4s0vA-5jbgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 ILE A 949
PRO A1006
HIS A1081
VAL A1043
 None
 1.31A 4s0vA-5jtvA:
undetectable		 4s0vA-5jtvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 ILE A 358
HIS A 219
TYR A 135
VAL A 149
 None
 1.05A 4s0vA-5l1bA:
4.0		 4s0vA-5l1bA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 ILE A  66
PRO A  65
TYR A 687
VAL A 810
 None
 0.67A 4s0vA-5lq3A:
undetectable		 4s0vA-5lq3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n48 FIBRONECTIN
NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		no annotation 4 ILE A  97
PRO A 103
TYR B1323
VAL B1325
 None
 1.16A 4s0vA-5n48A:
undetectable		 4s0vA-5n48A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL

(Rhodopseudomonas
palustris) 		no annotation 4 ILE A 275
HIS A 108
TYR A  89
VAL A  93
 None
 1.20A 4s0vA-5oeiA:
undetectable		 4s0vA-5oeiA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 ILE A 226
PRO A 227
HIS A 152
TYR A 161
 None
 1.25A 4s0vA-5szsA:
undetectable		 4s0vA-5szsA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4z RIBOFLAVIN LYASE

(Herbiconiux) 		no annotation 4 ILE A 404
PRO A 400
HIS A  35
VAL A 302
 None
 1.16A 4s0vA-5w4zA:
undetectable		 4s0vA-5w4zA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 ILE A 358
HIS A 219
TYR A 135
VAL A 149
 None
AJP  A1302 (-4.3A)
None
None
 1.03A 4s0vA-5welA:
4.7		 4s0vA-5welA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		4 ILE A 963
PRO A 962
HIS A1069
TYR A1094
 None
None
None
EDO  A1206 ( 3.9A)
 1.31A 4s0vA-5wqwA:
undetectable		 4s0vA-5wqwA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE

(Homo sapiens) 		no annotation 4 ILE A 128
PRO A 125
TYR A 220
VAL A  47
 None
 1.34A 4s0vA-5wy0A:
2.3		 4s0vA-5wy0A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 ILE A 464
PRO A 463
TYR A 541
VAL A 530
 None
 1.35A 4s0vA-5x59A:
undetectable		 4s0vA-5x59A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 4 ILE A 189
PRO A 217
TYR A  26
VAL A  11
 None
 1.33A 4s0vA-5x8hA:
6.2		 4s0vA-5x8hA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 ILE F 374
HIS F 209
TYR F  14
VAL F  17
 None
 1.26A 4s0vA-5xagF:
undetectable		 4s0vA-5xagF:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 ILE A 298
PRO A 299
HIS A 366
VAL A 280
 None
 1.27A 4s0vA-5xjnA:
undetectable		 4s0vA-5xjnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrt -

(-) 		no annotation 4 ILE A 217
PRO A 185
TYR A 233
VAL A 213
 None
 0.84A 4s0vA-5xrtA:
undetectable		 4s0vA-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE

(Trichomonas
vaginalis) 		PF00177
(Ribosomal_S7) 		4 ILE F  89
PRO F  97
HIS F  35
VAL F 105
 None
 1.27A 4s0vA-5xyiF:
undetectable		 4s0vA-5xyiF:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 4 ILE A 395
HIS A 288
TYR A 283
VAL A 360
 None
NDP  A 502 ( 3.0A)
None
None
 1.01A 4s0vA-5yvsA:
undetectable		 4s0vA-5yvsA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqj KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Staphylococcus
aureus) 		no annotation 4 ILE A  84
PRO A  81
HIS A 134
VAL A  22
 NDP  A 407 (-4.3A)
NDP  A 407 (-3.7A)
GOL  A 405 (-4.1A)
None
 1.03A 4s0vA-6aqjA:
2.8		 4s0vA-6aqjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bkp HEMAGGLUTININ

(Influenza A
virus) 		no annotation 4 ILE A 217
PRO A 185
TYR A 233
VAL A 213
 None
 0.88A 4s0vA-6bkpA:
undetectable		 4s0vA-6bkpA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 4 ILE A 750
PRO A 749
TYR A 646
VAL A 745
 None
 1.36A 4s0vA-6c01A:
undetectable		 4s0vA-6c01A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 4 ILE A 484
PRO A 483
TYR A 330
VAL A 340
 None
 1.21A 4s0vA-6ei1A:
undetectable		 4s0vA-6ei1A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 ILE A 309
PRO A 285
TYR A  28
VAL A  49
 None
 1.23A 4s0vA-6enoA:
3.8		 4s0vA-6enoA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ILE A 126
PRO A 128
HIS A 173
VAL A  90
 None
 1.31A 4s0vA-6ewjA:
undetectable		 4s0vA-6ewjA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 4 ILE S 367
PRO S 366
HIS S 139
TYR S 228
 None
 1.36A 4s0vA-6g79S:
26.2		 4s0vA-6g79S:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 4 ILE A 418
PRO A 549
HIS A 383
VAL A 378
 None
 1.28A 4s0vA-6gl3A:
undetectable		 4s0vA-6gl3A:
undetectable