SIMILAR PATTERNS OF AMINO ACIDS FOR 4S0V_A_SUVA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		5 THR A 214
VAL A 233
GLN A 203
GLU A 268
ILE A 230
 None
 1.32A 4s0vA-1c9lA:
undetectable		 4s0vA-1c9lA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		5 THR A 120
VAL A 121
VAL A 159
ILE A 153
ASN A 241
 None
None
None
HEM  A 501 (-4.3A)
None
 1.27A 4s0vA-1f26A:
undetectable		 4s0vA-1f26A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		5 THR A 202
GLN A  80
THR A  81
VAL A  84
GLU A 100
 PLP  A 342 (-2.9A)
None
None
None
None
 1.15A 4s0vA-1f2dA:
undetectable		 4s0vA-1f2dA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		5 GLN A  57
GLU A  60
ILE A 208
ASN A  36
TYR A  29
 ICP  A2001 (-3.3A)
None
TZP  A2005 (-3.6A)
None
ICP  A2001 (-4.2A)
 1.25A 4s0vA-1g67A:
2.6		 4s0vA-1g67A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		5 THR A  84
THR A 116
VAL A 117
ILE A  72
TYR A  87
 None
 1.28A 4s0vA-1i41A:
3.1		 4s0vA-1i41A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 THR A 292
VAL A 294
GLN A 458
THR A 457
GLN A 460
 None
 1.49A 4s0vA-1k25A:
undetectable		 4s0vA-1k25A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 THR A 142
VAL A 106
THR A 370
VAL A 374
GLN A 136
 None
 1.41A 4s0vA-1kkrA:
undetectable		 4s0vA-1kkrA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pox PYRUVATE OXIDASE

(Lactobacillus
plantarum) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 THR A 206
VAL A 202
THR A 236
GLN A 232
ILE A 217
 None
 1.36A 4s0vA-1poxA:
2.5		 4s0vA-1poxA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pseudomonas sp.
ACP) 		PF00291
(PALP) 		5 THR A 199
GLN A  80
THR A  81
VAL A  84
GLU A 100
 PLP  A 401 ( 2.8A)
None
None
None
None
 0.95A 4s0vA-1tzmA:
undetectable		 4s0vA-1tzmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		5 VAL A 531
GLN A 496
GLU A 492
ILE A 517
ASN A 521
 None
 1.20A 4s0vA-1u2zA:
2.7		 4s0vA-1u2zA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		5 THR A  72
VAL A  69
GLN A   8
ILE A  26
TYR A  33
 None
 1.39A 4s0vA-1v6cA:
3.8		 4s0vA-1v6cA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cex PROTEIN HI0146

(Haemophilus
influenzae) 		PF03480
(DctP) 		5 GLU A 253
ILE A 210
ASN A 212
HIS A 209
TYR A  85
 None
 1.38A 4s0vA-2cexA:
undetectable		 4s0vA-2cexA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 THR A 299
VAL A 295
THR A  11
ILE A  82
ASN A  81
 None
 1.36A 4s0vA-2eklA:
5.3		 4s0vA-2eklA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 304
VAL A 306
THR A 278
GLU A 284
ILE A  15
 None
None
None
None
FAD  A8482 (-4.5A)
 1.49A 4s0vA-2eq9A:
3.0		 4s0vA-2eq9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh8 CAPSID PROTEIN

(Vesicular
exanthema of
swine virus) 		PF00915
(Calici_coat) 		5 THR A 458
VAL A 586
THR A 620
VAL A 612
TYR A 497
 None
 1.24A 4s0vA-2gh8A:
undetectable		 4s0vA-2gh8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 VAL A  74
THR A 178
VAL A  29
ILE A 175
TYR A 160
 None
 1.34A 4s0vA-2h2qA:
undetectable		 4s0vA-2h2qA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 THR A 882
VAL A 881
THR A 588
VAL A 591
GLU A 582
 None
 1.32A 4s0vA-2qf7A:
undetectable		 4s0vA-2qf7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjg PUTATIVE ALDOLASE
MJ0400

(Methanocaldococcus
jannaschii) 		PF01791
(DeoC) 		5 VAL A  36
THR A 104
VAL A 105
ILE A 118
HIS A  85
 None
 1.39A 4s0vA-2qjgA:
undetectable		 4s0vA-2qjgA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d) 		5 THR A 232
VAL A 236
VAL A 220
GLN A 177
GLU A 216
 None
None
None
GAX  A 352 (-4.0A)
GAX  A 352 (-3.7A)
 1.11A 4s0vA-2rhqA:
undetectable		 4s0vA-2rhqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 THR A 113
VAL A 116
THR B 520
GLU A 135
ILE B 581
 None
 1.32A 4s0vA-2rhqA:
undetectable		 4s0vA-2rhqA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 VAL G 488
TRP G 490
THR G 279
GLN G 245
ILE G 306
 None
 0.87A 4s0vA-2uv8G:
undetectable		 4s0vA-2uv8G:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 THR A 176
THR A 250
VAL A 249
ILE A  62
HIS A 134
 None
 1.31A 4s0vA-2vhlA:
undetectable		 4s0vA-2vhlA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		5 THR A 377
THR A 370
ASN A 266
HIS A 374
TYR A 457
 None
None
FAD  A1463 (-4.6A)
None
None
 1.36A 4s0vA-2xryA:
undetectable		 4s0vA-2xryA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 VAL A 395
GLN A 343
VAL A 337
ILE A 387
ASN A 406
 None
 1.40A 4s0vA-2y8nA:
2.0		 4s0vA-2y8nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 THR A 908
VAL A 907
THR A 611
VAL A 614
GLU A 605
 None
 1.35A 4s0vA-3bg9A:
undetectable		 4s0vA-3bg9A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c02 AQUAGLYCEROPORIN

(Plasmodium
falciparum) 		PF00230
(MIP) 		5 THR A 103
VAL A 106
GLU A 125
ILE A 119
HIS A  35
 None
 1.20A 4s0vA-3c02A:
2.3		 4s0vA-3c02A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 THR A  90
THR A  80
VAL A  79
ILE A  60
ASN A  61
 None
 1.21A 4s0vA-3dkhA:
undetectable		 4s0vA-3dkhA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY

(Bacillus
anthracis) 		PF02567
(PhzC-PhzF) 		5 THR A 229
VAL A 228
THR A 160
ILE A 166
HIS A 198
 SO4  A 300 (-4.5A)
None
None
None
None
 1.27A 4s0vA-3ednA:
undetectable		 4s0vA-3ednA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 VAL A 449
GLN A 107
ILE A 181
ASN A 155
HIS A 383
 None
None
None
None
ZN  A 757 ( 3.4A)
 1.42A 4s0vA-3eqnA:
undetectable		 4s0vA-3eqnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
pseudomallei) 		PF02548
(Pantoate_transf) 		5 THR A  21
THR A  55
GLU A 112
ILE A  63
TYR A  23
 None
 1.27A 4s0vA-3ez4A:
3.2		 4s0vA-3ez4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
pseudomallei) 		PF02548
(Pantoate_transf) 		5 THR A  21
THR A  55
VAL A  58
GLU A 112
TYR A  23
 None
 1.44A 4s0vA-3ez4A:
3.2		 4s0vA-3ez4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez4 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Burkholderia
pseudomallei) 		PF02548
(Pantoate_transf) 		5 VAL A 210
THR A  55
VAL A  58
GLU A 112
TYR A  23
 None
 1.40A 4s0vA-3ez4A:
3.2		 4s0vA-3ez4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9s PUTATIVE POLYKETIDE
CYCLASE

(Acidithiobacillus
ferrooxidans) 		PF07366
(SnoaL) 		5 THR A 113
VAL A  18
GLN A  69
HIS A 125
TYR A 115
 GOL  A 146 ( 4.1A)
None
None
GOL  A 146 (-4.1A)
None
 0.99A 4s0vA-3f9sA:
undetectable		 4s0vA-3f9sA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmc PUTATIVE
SUCCINYLGLUTAMATE
DESUCCINYLASE /
ASPARTOACYLASE

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		5 VAL A   8
GLN A  38
ILE A  52
ASN A  49
TYR A  36
 None
 1.33A 4s0vA-3fmcA:
2.7		 4s0vA-3fmcA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		5 GLN A  45
THR A 137
ILE A 223
ASN A 174
HIS A 251
 None
 1.29A 4s0vA-3g6sA:
undetectable		 4s0vA-3g6sA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 THR A 168
VAL A 174
GLN A 303
GLU A 300
ILE A 181
 None
 1.35A 4s0vA-3ihjA:
2.3		 4s0vA-3ihjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwu SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE

(Shewanella
frigidimarina) 		PF04952
(AstE_AspA) 		5 VAL A   9
GLN A  40
ILE A  54
ASN A  51
TYR A  38
 None
 1.34A 4s0vA-3lwuA:
2.2		 4s0vA-3lwuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE

(Saccharomyces
cerevisiae) 		PF00282
(Pyridoxal_deC) 		5 VAL C 173
TRP C 164
GLN C 184
THR C 185
ILE C 427
 None
 1.37A 4s0vA-3mc6C:
undetectable		 4s0vA-3mc6C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 THR A  20
THR A 342
ILE A  35
ASN A 350
HIS A  39
 None
 1.36A 4s0vA-3nz4A:
undetectable		 4s0vA-3nz4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rom ADP-RIBOSYL CYCLASE
1

(Homo sapiens) 		PF02267
(Rib_hydrolayse) 		5 VAL A  85
GLN A 115
THR A 116
VAL A 117
TYR A  70
 None
 1.49A 4s0vA-3romA:
undetectable		 4s0vA-3romA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 THR A 662
VAL A 653
GLN A 668
VAL A 832
HIS A 648
 None
 1.49A 4s0vA-4at3A:
undetectable		 4s0vA-4at3A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eiu UNCHARACTERIZED
HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF12866
(DUF3823) 		5 THR A 251
VAL A 253
VAL A  47
GLN A 134
ILE A  97
 None
PEG  A 302 (-4.8A)
None
None
None
 1.13A 4s0vA-4eiuA:
undetectable		 4s0vA-4eiuA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 THR A 336
VAL A 304
GLN A 339
ILE A 300
TYR A 352
 None
 1.42A 4s0vA-4eviA:
undetectable		 4s0vA-4eviA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 117
THR A 154
VAL A 101
GLN A 158
ILE A 151
 None
None
0RS  A 900 (-4.5A)
None
None
 1.16A 4s0vA-4ez5A:
undetectable		 4s0vA-4ez5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 THR A 882
VAL A 881
THR A 588
VAL A 591
GLU A 582
 PYR  A1101 (-4.4A)
None
None
None
None
 1.31A 4s0vA-4jx6A:
undetectable		 4s0vA-4jx6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3g IMMUNOGLOBULIN
LAMBDA VARIABLE
DOMAIN L5(L89S)

(Homo sapiens) 		PF07686
(V-set) 		5 THR A 105
VAL A 106
GLN A 103
GLU A  85
ILE A  75
 None
 1.48A 4s0vA-4k3gA:
undetectable		 4s0vA-4k3gA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 TRP A 305
GLN A 606
THR A 609
VAL A 608
ILE A 571
 None
 1.47A 4s0vA-4k6mA:
undetectable		 4s0vA-4k6mA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 5 THR H 874
VAL H 873
THR H 580
VAL H 583
GLU H 574
 None
 1.41A 4s0vA-4qslH:
3.5		 4s0vA-4qslH:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		5 THR A 366
GLN A 197
THR A 173
ILE A 136
HIS A 194
 None
None
None
None
ASC  A 501 (-4.1A)
 1.48A 4s0vA-4rp8A:
undetectable		 4s0vA-4rp8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv3 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Staphylococcus
aureus) 		PF00388
(PI-PLC-X) 		5 VAL A 237
THR A  48
GLN A  49
ILE A 259
ASN A 260
 None
None
None
PF5  A 258 ( 4.4A)
None
 1.12A 4s0vA-4rv3A:
undetectable		 4s0vA-4rv3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 TRP A 181
THR A 247
VAL A 216
ASN A  47
HIS A 128
 None
 1.36A 4s0vA-4v2xA:
undetectable		 4s0vA-4v2xA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpx BACTERIOHEMERYTHRIN

(Methylococcus
capsulatus) 		PF01814
(Hemerythrin) 		5 THR A  13
VAL A  15
GLU A  63
ILE A  25
HIS A  22
 None
None
None
None
FE2  A 202 (-3.3A)
 1.45A 4s0vA-4xpxA:
4.3		 4s0vA-4xpxA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yvd PLEIOTROPIC
REGULATOR 1

(Homo sapiens) 		PF00400
(WD40) 		5 VAL A 450
THR A 420
VAL A 379
ILE A 416
HIS A 412
 None
UNX  A 615 ( 3.8A)
UNX  A 617 ( 4.1A)
None
None
 1.33A 4s0vA-4yvdA:
undetectable		 4s0vA-4yvdA:
20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		10 VAL A 106
TRP A 112
GLN A 126
VAL A 130
GLN A 179
GLU A 204
ILE A 314
ASN A 318
HIS A 344
TYR A 348
 SUV  A2001 (-4.5A)
None
SUV  A2001 (-3.8A)
SUV  A2001 (-4.7A)
SUV  A2001 (-3.3A)
SUV  A2001 (-4.4A)
SUV  A2001 (-3.8A)
SUV  A2001 (-2.9A)
SUV  A2001 (-3.5A)
SUV  A2001 (-4.8A)
 0.52A 4s0vA-4zj8A:
46.2		 4s0vA-4zj8A:
83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b48 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N) 		5 THR A 340
VAL A 338
THR A 236
HIS A 404
TYR A 342
 None
 1.23A 4s0vA-5b48A:
3.6		 4s0vA-5b48A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 VAL X 367
VAL X 303
GLU X 411
ILE X 310
HIS X 315
 None
 1.41A 4s0vA-5evyX:
3.5		 4s0vA-5evyX:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcs DIABODY

(Homo sapiens) 		PF07686
(V-set) 		5 THR L  81
VAL L 109
GLN L 121
GLU L 119
ILE L  76
 None
 1.49A 4s0vA-5fcsL:
undetectable		 4s0vA-5fcsL:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcs DIABODY

(Homo sapiens) 		PF07686
(V-set) 		5 THR L  81
VAL L 109
GLN L 121
GLU L 119
TYR L  87
 None
 1.48A 4s0vA-5fcsL:
undetectable		 4s0vA-5fcsL:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fui ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF03422
(CBM_6) 		5 VAL A 317
GLN A 356
THR A 357
VAL A 358
ILE A 383
 None
 1.33A 4s0vA-5fuiA:
undetectable		 4s0vA-5fuiA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy3 ANTITOXIN DMD
MRNA
ENDORIBONUCLEASE
LSOA

(Escherichia
coli;
Escherichia
virus T4) 		PF15935
(RnlA_toxin)
PF17587
(Dmd) 		5 THR B  34
VAL B  56
GLN B  35
GLU A 246
TYR A  94
 None
 1.40A 4s0vA-5hy3B:
undetectable		 4s0vA-5hy3B:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 THR T3568
TRP T3743
THR T3257
ASN T3250
HIS T3570
 None
 1.29A 4s0vA-5ojsT:
undetectable		 4s0vA-5ojsT:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 THR A 473
VAL A 491
THR A 372
ILE A 435
TYR A 516
 None
None
EDO  A 907 (-4.5A)
None
None
 1.34A 4s0vA-5t98A:
undetectable		 4s0vA-5t98A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwz ALDEHYDE
DECARBONYLASE

(Gloeobacter
violaceus) 		no annotation 5 THR A  42
GLN A  96
GLN A  97
GLU A 101
ILE A 110
 None
EDO  A 301 ( 4.9A)
None
None
None
 1.31A 4s0vA-5uwzA:
2.3		 4s0vA-5uwzA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 THR A 232
VAL A 227
GLN A 234
GLU A 418
ILE A 245
 None
FAD  A 503 (-4.1A)
None
None
None
 1.19A 4s0vA-5vj7A:
3.4		 4s0vA-5vj7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1y MERCURIC REDUCTASE

(Lysinibacillus
sphaericus) 		no annotation 5 THR B 428
VAL B 432
VAL B 254
GLN B 279
ILE B 260
 None
None
None
None
FAD  B 601 ( 3.8A)
 1.35A 4s0vA-5x1yB:
undetectable		 4s0vA-5x1yB:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		4 ILE A  80
PRO A  81
TYR A 144
VAL A 148
 None
 1.24A 4s0vA-1edgA:
undetectable		 4s0vA-1edgA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 198
HIS A 247
TYR A 308
VAL A 312
 None
 0.89A 4s0vA-1j0hA:
undetectable		 4s0vA-1j0hA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 195
HIS A 244
TYR A 306
VAL A 310
 None
 0.98A 4s0vA-1jf5A:
undetectable		 4s0vA-1jf5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 212
HIS A 244
TYR A 306
VAL A 310
 None
 1.20A 4s0vA-1jf5A:
undetectable		 4s0vA-1jf5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lme PEPTIDE DEFORMYLASE

(Thermotoga
maritima) 		PF01327
(Pep_deformylase) 		4 ILE A  34
PRO A  65
TYR A 122
VAL A 126
 None
 1.24A 4s0vA-1lmeA:
undetectable		 4s0vA-1lmeA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 CYTOCHROME B6
CYTOCHROME B6-F
COMPLEX IRON-SULFUR
SUBUNIT

(Chlamydomonas
reinhardtii) 		PF00033
(Cytochrome_B)
PF00355
(Rieske) 		4 ILE B 165
PRO B 155
HIS C 155
VAL B 175
 TDS  D 920 ( 4.7A)
TDS  D 920 ( 4.7A)
FES  C 210 ( 3.0A)
None
 1.35A 4s0vA-1q90B:
6.0		 4s0vA-1q90B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 ILE A 375
HIS A 277
TYR A 273
VAL A 345
 None
ZN  A 387 (-3.3A)
None
None
 1.14A 4s0vA-1rrmA:
2.5		 4s0vA-1rrmA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 ILE A 198
HIS A 247
TYR A 308
VAL A 312
 None
 0.89A 4s0vA-1smaA:
undetectable		 4s0vA-1smaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbc POLIOVIRUS TYPE 3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3  49
HIS 3 230
TYR 3 107
VAL 3 222
 None
 1.29A 4s0vA-1vbc3:
undetectable		 4s0vA-1vbc3:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		4 ILE A  46
PRO A  47
TYR A 155
VAL A  15
 None
 1.34A 4s0vA-1vzvA:
undetectable		 4s0vA-1vzvA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7z HUMAN COXSACKIEVIRUS
A21

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3  49
HIS 3 229
TYR 3 106
VAL 3 221
 None
 1.29A 4s0vA-1z7z3:
undetectable		 4s0vA-1z7z3:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 ILE A  67
PRO A  65
HIS A  81
VAL A  91
 None
 1.30A 4s0vA-2dfsA:
undetectable		 4s0vA-2dfsA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ILE A 274
PRO A 273
TYR A 309
VAL A 285
 None
 1.12A 4s0vA-2ebdA:
undetectable		 4s0vA-2ebdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ILE A 312
PRO A 313
HIS A 259
TYR A 601
 None
 1.30A 4s0vA-2fjaA:
3.3		 4s0vA-2fjaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 PRO A 132
HIS A 368
TYR A 277
VAL A 258
 None
 1.34A 4s0vA-2gmhA:
4.4		 4s0vA-2gmhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 PRO A 362
HIS A 368
TYR A 277
VAL A 258
 None
 1.14A 4s0vA-2gmhA:
4.4		 4s0vA-2gmhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		4 ILE A 267
PRO A 288
TYR A 254
VAL A 258
 None
 1.33A 4s0vA-2h1yA:
3.4		 4s0vA-2h1yA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 ILE A 115
HIS A 155
TYR A  39
VAL A  91
 None
 1.35A 4s0vA-2iu4A:
undetectable		 4s0vA-2iu4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfe CYTOSOLIC
BETA-GLUCOSIDASE

(Homo sapiens) 		PF00232
(Glyco_hydro_1) 		4 ILE X  66
HIS X 120
TYR X 370
VAL X 413
 None
 1.34A 4s0vA-2jfeX:
undetectable		 4s0vA-2jfeX:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 138
PRO A  32
TYR A 185
VAL A 152
 None
 1.30A 4s0vA-2nz9A:
undetectable		 4s0vA-2nz9A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		4 ILE A 444
PRO A 443
HIS A 491
VAL A 419
 None
 1.32A 4s0vA-2oudA:
undetectable		 4s0vA-2oudA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A1298
PRO A1297
HIS A1239
TYR A1706
 None
 1.30A 4s0vA-2pffA:
5.1		 4s0vA-2pffA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psm INTERLEUKIN-15
RECEPTOR ALPHA CHAIN

(Mus musculus) 		no annotation 4 ILE F  10
HIS F  56
TYR F  20
VAL F  17
 None
 1.05A 4s0vA-2psmF:
undetectable		 4s0vA-2psmF:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3o 12-OXOPHYTODIENOATE
REDUCTASE 3

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		4 ILE A  61
PRO A  31
HIS A 245
VAL A  77
 None
FMN  A7401 (-4.3A)
None
None
 1.35A 4s0vA-2q3oA:
undetectable		 4s0vA-2q3oA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		4 ILE A 278
HIS A 186
TYR A 207
VAL A 234
 None
 1.23A 4s0vA-2ragA:
undetectable		 4s0vA-2ragA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E1 ENVELOPE
GLYCOPROTEIN
E2 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 ILE A  55
PRO B 304
TYR A  93
VAL A  60
 None
 1.34A 4s0vA-2xfbA:
undetectable		 4s0vA-2xfbA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp2 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 217
PRO A 185
TYR A 233
VAL A 213
 None
 0.86A 4s0vA-2yp2A:
undetectable		 4s0vA-2yp2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		4 ILE A 240
PRO A 262
HIS A 346
VAL A 196
 None
 1.33A 4s0vA-3ax6A:
3.1		 4s0vA-3ax6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 ILE A 379
HIS A 281
TYR A 277
VAL A 349
 None
FE2  A1388 (-3.6A)
None
None
 1.10A 4s0vA-3bfjA:
2.7		 4s0vA-3bfjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 ILE A 382
HIS A 281
TYR A 277
VAL A 349
 None
FE2  A1388 (-3.6A)
None
None
 1.08A 4s0vA-3bfjA:
2.7		 4s0vA-3bfjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		4 ILE A 535
PRO A 530
HIS A 525
VAL A 142
 None
 1.33A 4s0vA-3biwA:
undetectable		 4s0vA-3biwA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ILE A 342
PRO A 341
HIS A 356
VAL A 321
 None
None
None
UDP  A 600 ( 3.9A)
 1.04A 4s0vA-3c4qA:
22.9		 4s0vA-3c4qA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ILE A 210
PRO A 325
HIS A 248
VAL A 305
 None
 1.23A 4s0vA-3cp8A:
undetectable		 4s0vA-3cp8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		4 ILE A  45
HIS A 276
TYR A  22
VAL A  31
 None
 1.20A 4s0vA-3dhuA:
undetectable		 4s0vA-3dhuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 ILE A 470
HIS A 357
TYR A 420
VAL A 425
 None
 1.28A 4s0vA-3fdhA:
undetectable		 4s0vA-3fdhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE A 352
HIS A 213
TYR A 129
VAL A 143
 None
NAG  A 383 (-3.8A)
None
None
 1.14A 4s0vA-3hsyA:
5.2		 4s0vA-3hsyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 ILE A 423
HIS A 332
TYR A 212
VAL A 342
 None
M44  A 518 (-3.7A)
M44  A 518 (-3.6A)
None
 1.36A 4s0vA-3l7gA:
undetectable		 4s0vA-3l7gA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 163
PRO A 193
HIS A 234
VAL A 201
 None
 1.31A 4s0vA-3mwcA:
undetectable		 4s0vA-3mwcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		4 ILE A  97
HIS A 175
TYR A 196
VAL A 167
 None
 1.26A 4s0vA-3vmwA:
undetectable		 4s0vA-3vmwA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 348
HIS A 184
TYR A 197
VAL A 249
 None
FAD  A 607 (-3.8A)
None
None
 1.20A 4s0vA-3vteA:
undetectable		 4s0vA-3vteA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl4 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02585
(PIG-L) 		4 ILE A  35
HIS A 151
TYR A 109
VAL A 120
 None
CD  A 301 ( 3.5A)
None
None
 1.27A 4s0vA-3wl4A:
2.1		 4s0vA-3wl4A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxm PROTEIN PELOTA
HOMOLOG

(Aeropyrum
pernix) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 ILE B 250
PRO B 326
HIS B 298
VAL B 322
 None
 1.33A 4s0vA-3wxmB:
undetectable		 4s0vA-3wxmB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c25 L-FUCULOSE PHOSPHATE
ALDOLASE

(Streptococcus
pneumoniae) 		PF00596
(Aldolase_II) 		4 ILE A  45
PRO A  42
HIS A  78
TYR A 131
 None
 1.28A 4s0vA-4c25A:
undetectable		 4s0vA-4c25A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 ILE B  31
PRO B  30
HIS B 194
TYR B  22
 None
 1.27A 4s0vA-4ccyB:
2.6		 4s0vA-4ccyB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		4 ILE A 198
PRO A 199
TYR A 168
VAL A 172
 None
None
TRS  A 401 (-4.5A)
None
 0.96A 4s0vA-4d9iA:
undetectable		 4s0vA-4d9iA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 143
HIS A 157
TYR A 228
VAL A 213
 None
 1.36A 4s0vA-4d9rA:
undetectable		 4s0vA-4d9rA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ILE A 539
PRO A 536
HIS A 522
VAL A 202
 None
 1.28A 4s0vA-4di5A:
undetectable		 4s0vA-4di5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Dickeya
paradisiaca) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 330
PRO A 327
HIS A 225
TYR A 247
 None
GOL  A 502 (-4.5A)
GOL  A 502 (-4.4A)
None
 1.09A 4s0vA-4ihcA:
undetectable		 4s0vA-4ihcA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhy HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF14730
(DUF4468) 		4 ILE A 153
PRO A 156
TYR A  38
VAL A  36
 None
 1.13A 4s0vA-4jhyA:
undetectable		 4s0vA-4jhyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpz FIBROBLAST GROWTH
FACTOR 13
SODIUM CHANNEL
PROTEIN TYPE 2
SUBUNIT ALPHA

(Homo sapiens) 		PF00167
(FGF)
PF00612
(IQ)
PF16905
(GPHH) 		4 ILE A  52
PRO A  53
HIS B1853
VAL A 100
 None
 1.27A 4s0vA-4jpzA:
undetectable		 4s0vA-4jpzA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0v EXONUCLEASE SUBUNIT
SBCD

(Escherichia
coli) 		PF00149
(Metallophos)
PF12320
(SbcD_C) 		4 ILE A 242
PRO A 241
HIS A   5
VAL A 196
 None
 1.28A 4s0vA-4m0vA:
undetectable		 4s0vA-4m0vA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 PRO A 239
HIS A 452
TYR A 477
VAL A 475
 None
 1.30A 4s0vA-4mifA:
2.6		 4s0vA-4mifA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 ILE A 309
PRO A 310
HIS A 206
VAL A 189
 None
 1.36A 4s0vA-4nfuA:
undetectable		 4s0vA-4nfuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 479
PRO A 480
HIS A 401
VAL A 310
 None
 1.27A 4s0vA-4nkyA:
undetectable		 4s0vA-4nkyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 ILE A 277
PRO A  12
TYR A  26
VAL A  25
 None
 1.36A 4s0vA-4oyaA:
undetectable		 4s0vA-4oyaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE A 432
PRO A 428
TYR A 650
VAL A 649
 None
 1.09A 4s0vA-4pj3A:
undetectable		 4s0vA-4pj3A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1z PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF16215
(DUF4876) 		4 ILE A 253
HIS A 204
TYR A 339
VAL A 260
 None
 1.28A 4s0vA-4q1zA:
undetectable		 4s0vA-4q1zA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP3

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 3  49
HIS 3 229
TYR 3 106
VAL 3 221
 None
 1.24A 4s0vA-4q4y3:
undetectable		 4s0vA-4q4y3:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnw CHANOCLAVINE-I
ALDEHYDE REDUCTASE

(Aspergillus
fumigatus) 		PF00724
(Oxidored_FMN) 		4 ILE A  61
PRO A  29
TYR A 359
VAL A  45
 None
FMN  A 401 (-3.7A)
None
None
 1.31A 4s0vA-4qnwA:
undetectable		 4s0vA-4qnwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ILE A 212
PRO A 213
TYR A 186
VAL A 192
 None
 1.30A 4s0vA-4uzsA:
3.8		 4s0vA-4uzsA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4we6 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ILE A 177
PRO A 145
TYR A 193
VAL A 173
 None
 0.90A 4s0vA-4we6A:
undetectable		 4s0vA-4we6A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z96 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg)
PF14533
(USP7_C2) 		4 ILE A 949
PRO A1006
HIS A1081
VAL A1043
 None
 1.32A 4s0vA-4z96A:
undetectable		 4s0vA-4z96A:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 ILE A 122
PRO A 123
HIS A 216
TYR A 311
VAL A 347
 SUV  A2001 ( 4.8A)
SUV  A2001 (-3.9A)
SUV  A2001 ( 4.8A)
None
SUV  A2001 ( 4.6A)
 0.34A 4s0vA-4zj8A:
46.2		 4s0vA-4zj8A:
83.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		4 ILE A  89
HIS A 140
TYR A 193
VAL A 197
 None
ACT  A1479 (-4.4A)
None
None
 0.98A 4s0vA-5a2aA:
undetectable		 4s0vA-5a2aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 ILE A 381
PRO A 305
HIS A 299
VAL A 226
 None
 1.34A 4s0vA-5djqA:
3.0		 4s0vA-5djqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e55 CONTACTIN-6

(Mus musculus) 		PF00041
(fn3) 		4 ILE A 724
PRO A 725
TYR A 671
VAL A 669
 None
 1.33A 4s0vA-5e55A:
undetectable		 4s0vA-5e55A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f06 GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A  54
PRO A  55
HIS A 169
VAL A 208
 GSH  A 301 (-4.2A)
GSH  A 301 ( 4.8A)
None
None
 1.33A 4s0vA-5f06A:
undetectable		 4s0vA-5f06A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 ILE A 348
PRO A 309
TYR A 268
VAL A 315
 None
 1.16A 4s0vA-5f0oA:
undetectable		 4s0vA-5f0oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		4 ILE A  32
HIS A 145
TYR A 234
VAL A 263
 None
ZN  A 403 ( 3.3A)
None
None
 1.21A 4s0vA-5fbbA:
undetectable		 4s0vA-5fbbA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fql IDURONATE-2-SULFATAS
E

(Homo sapiens) 		PF00884
(Sulfatase) 		4 ILE A  42
HIS A 356
TYR A 300
VAL A 304
 None
 1.34A 4s0vA-5fqlA:
undetectable		 4s0vA-5fqlA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 ILE A  92
PRO A  93
HIS A 123
TYR A 105
 None
 1.24A 4s0vA-5fv4A:
undetectable		 4s0vA-5fv4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 ILE A 325
PRO A 326
HIS A 393
VAL A 307
 None
 1.25A 4s0vA-5gweA:
undetectable		 4s0vA-5gweA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 ILE A  22
PRO A  21
HIS A 179
TYR A  96
 None
None
VDM  A 502 (-3.6A)
None
 1.26A 4s0vA-5hvoA:
6.4		 4s0vA-5hvoA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 PRO A 641
HIS A 553
TYR A 647
VAL A 653
 None
 1.31A 4s0vA-5jbgA:
undetectable		 4s0vA-5jbgA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 ILE A 949
PRO A1006
HIS A1081
VAL A1043
 None
 1.31A 4s0vA-5jtvA:
undetectable		 4s0vA-5jtvA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 ILE A 358
HIS A 219
TYR A 135
VAL A 149
 None
 1.05A 4s0vA-5l1bA:
4.0		 4s0vA-5l1bA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 ILE A  66
PRO A  65
TYR A 687
VAL A 810
 None
 0.67A 4s0vA-5lq3A:
undetectable		 4s0vA-5lq3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n48 FIBRONECTIN
NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		no annotation 4 ILE A  97
PRO A 103
TYR B1323
VAL B1325
 None
 1.16A 4s0vA-5n48A:
undetectable		 4s0vA-5n48A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL

(Rhodopseudomonas
palustris) 		no annotation 4 ILE A 275
HIS A 108
TYR A  89
VAL A  93
 None
 1.20A 4s0vA-5oeiA:
undetectable		 4s0vA-5oeiA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 ILE A 226
PRO A 227
HIS A 152
TYR A 161
 None
 1.25A 4s0vA-5szsA:
undetectable		 4s0vA-5szsA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4z RIBOFLAVIN LYASE

(Herbiconiux) 		no annotation 4 ILE A 404
PRO A 400
HIS A  35
VAL A 302
 None
 1.16A 4s0vA-5w4zA:
undetectable		 4s0vA-5w4zA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 ILE A 358
HIS A 219
TYR A 135
VAL A 149
 None
AJP  A1302 (-4.3A)
None
None
 1.03A 4s0vA-5welA:
4.7		 4s0vA-5welA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		4 ILE A 963
PRO A 962
HIS A1069
TYR A1094
 None
None
None
EDO  A1206 ( 3.9A)
 1.31A 4s0vA-5wqwA:
undetectable		 4s0vA-5wqwA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE

(Homo sapiens) 		no annotation 4 ILE A 128
PRO A 125
TYR A 220
VAL A  47
 None
 1.34A 4s0vA-5wy0A:
2.3		 4s0vA-5wy0A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 ILE A 464
PRO A 463
TYR A 541
VAL A 530
 None
 1.35A 4s0vA-5x59A:
undetectable		 4s0vA-5x59A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8h SHORT-CHAIN
DEHYDROGENASE
REDUCTASE

(Chryseobacterium
sp. CA49) 		no annotation 4 ILE A 189
PRO A 217
TYR A  26
VAL A  11
 None
 1.33A 4s0vA-5x8hA:
6.2		 4s0vA-5x8hA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 ILE F 374
HIS F 209
TYR F  14
VAL F  17
 None
 1.26A 4s0vA-5xagF:
undetectable		 4s0vA-5xagF:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		4 ILE A 298
PRO A 299
HIS A 366
VAL A 280
 None
 1.27A 4s0vA-5xjnA:
undetectable		 4s0vA-5xjnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrt -

(-) 		no annotation 4 ILE A 217
PRO A 185
TYR A 233
VAL A 213
 None
 0.84A 4s0vA-5xrtA:
undetectable		 4s0vA-5xrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S5-B,
PUTATIVE

(Trichomonas
vaginalis) 		PF00177
(Ribosomal_S7) 		4 ILE F  89
PRO F  97
HIS F  35
VAL F 105
 None
 1.27A 4s0vA-5xyiF:
undetectable		 4s0vA-5xyiF:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 4 ILE A 395
HIS A 288
TYR A 283
VAL A 360
 None
NDP  A 502 ( 3.0A)
None
None
 1.01A 4s0vA-5yvsA:
undetectable		 4s0vA-5yvsA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqj KETOL-ACID
REDUCTOISOMERASE
(NADP(+))

(Staphylococcus
aureus) 		no annotation 4 ILE A  84
PRO A  81
HIS A 134
VAL A  22
 NDP  A 407 (-4.3A)
NDP  A 407 (-3.7A)
GOL  A 405 (-4.1A)
None
 1.03A 4s0vA-6aqjA:
2.8		 4s0vA-6aqjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bkp HEMAGGLUTININ

(Influenza A
virus) 		no annotation 4 ILE A 217
PRO A 185
TYR A 233
VAL A 213
 None
 0.88A 4s0vA-6bkpA:
undetectable		 4s0vA-6bkpA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 4 ILE A 750
PRO A 749
TYR A 646
VAL A 745
 None
 1.36A 4s0vA-6c01A:
undetectable		 4s0vA-6c01A:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 4 ILE A 484
PRO A 483
TYR A 330
VAL A 340
 None
 1.21A 4s0vA-6ei1A:
undetectable		 4s0vA-6ei1A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 ILE A 309
PRO A 285
TYR A  28
VAL A  49
 None
 1.23A 4s0vA-6enoA:
3.8		 4s0vA-6enoA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ILE A 126
PRO A 128
HIS A 173
VAL A  90
 None
 1.31A 4s0vA-6ewjA:
undetectable		 4s0vA-6ewjA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 4 ILE S 367
PRO S 366
HIS S 139
TYR S 228
 None
 1.36A 4s0vA-6g79S:
26.2		 4s0vA-6g79S:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 4 ILE A 418
PRO A 549
HIS A 383
VAL A 378
 None
 1.28A 4s0vA-6gl3A:
undetectable		 4s0vA-6gl3A:
undetectable