SIMILAR PATTERNS OF AMINO ACIDS FOR 4RZV_B_032B801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 PHE A  83
SER A 647
HIS A 668
ASP A 185
 None
 1.41A 4rzvB-1b0kA:
0.0		 4rzvB-1b0kA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bmt METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ILE A 832
SER A 838
HIS A 841
ASP A 757
 None
None
None
COB  A 122 (-4.1A)
 1.20A 4rzvB-1bmtA:
undetectable		 4rzvB-1bmtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 ILE A 155
SER A  80
HIS A 132
ASP A 264
 G6P  A 901 (-4.8A)
None
G6P  A 901 (-4.5A)
None
 1.37A 4rzvB-1gz5A:
0.0		 4rzvB-1gz5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		4 ILE A 128
PHE A  31
SER A 185
ASP A 214
 None
None
None
ZN  A1457 (-1.9A)
 1.39A 4rzvB-1ibqA:
undetectable		 4rzvB-1ibqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		4 ILE A 832
SER A 838
HIS A 841
ASP A 757
 None
 1.16A 4rzvB-1k7yA:
0.0		 4rzvB-1k7yA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q47 SEMAPHORIN 3A

(Mus musculus) 		PF01403
(Sema) 		4 ILE A 154
PHE A  80
HIS A 149
ASP A  63
 None
 1.25A 4rzvB-1q47A:
undetectable		 4rzvB-1q47A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF00022
(Actin)
PF04045
(P34-Arc) 		4 ILE A  97
PHE D 181
HIS A 108
ASP D 249
 None
 1.39A 4rzvB-1u2vA:
undetectable		 4rzvB-1u2vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF03070
(TENA_THI-4) 		4 ILE A   5
SER A 188
HIS A 187
ASP A  12
 None
 1.34A 4rzvB-1uddA:
0.6		 4rzvB-1uddA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 ILE A 597
PHE A 673
SER A 548
ASP A 683
 None
None
None
CA  A 802 (-3.2A)
 1.40A 4rzvB-1w7cA:
0.4		 4rzvB-1w7cA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ILE A  39
PHE A 396
SER A 365
ASP A 387
 None
 1.10A 4rzvB-1w9xA:
undetectable		 4rzvB-1w9xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 ILE A 414
PHE A 497
SER A 403
ASP A 408
 None
 1.23A 4rzvB-1wd3A:
undetectable		 4rzvB-1wd3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ILE A 638
PHE A  66
SER A 609
HIS A 617
 None
 1.30A 4rzvB-1wz2A:
undetectable		 4rzvB-1wz2A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 742
SER A 740
HIS A 824
ASP A 629
 None
 1.31A 4rzvB-1xfdA:
undetectable		 4rzvB-1xfdA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		4 ILE A 324
PHE A 233
HIS A 344
ASP A 220
 None
None
None
MG  A 400 (-2.7A)
 1.24A 4rzvB-1xfiA:
undetectable		 4rzvB-1xfiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 ILE A 230
PHE A 145
SER A 295
ASP A  40
 None
 1.37A 4rzvB-1xvxA:
undetectable		 4rzvB-1xvxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 ILE A 253
SER A 250
HIS A 175
ASP A 265
 None
 1.42A 4rzvB-1yyrA:
undetectable		 4rzvB-1yyrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		4 ILE A 178
PHE A   7
HIS A 375
ASP A 147
 None
 1.40A 4rzvB-2cunA:
undetectable		 4rzvB-2cunA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 ILE A 171
PHE A 146
SER A 226
ASP A 264
 None
 1.44A 4rzvB-2eezA:
undetectable		 4rzvB-2eezA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9i F420-0:GAMMA-GLUTAMY
L LIGASE

(Archaeoglobus
fulgidus) 		PF01996
(F420_ligase) 		4 ILE A 148
PHE A 201
SER A 168
ASP A 196
 None
 1.29A 4rzvB-2g9iA:
undetectable		 4rzvB-2g9iA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A  36
PHE A  58
SER A 337
HIS A 368
 None
 1.32A 4rzvB-2gqdA:
undetectable		 4rzvB-2gqdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 117
PHE A 384
SER A 126
ASP A 237
 None
 1.29A 4rzvB-2hi4A:
undetectable		 4rzvB-2hi4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmc DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 ILE A 104
PHE A 280
HIS A 120
ASP A  57
 MG  A 502 (-4.8A)
None
MG  A 502 (-4.6A)
None
 1.27A 4rzvB-2hmcA:
undetectable		 4rzvB-2hmcA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i54 PHOSPHOMANNOMUTASE

(Leishmania
mexicana) 		PF03332
(PMM) 		4 ILE A 157
PHE A 118
SER A 172
ASP A 147
 None
 1.42A 4rzvB-2i54A:
undetectable		 4rzvB-2i54A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		4 ILE B 333
SER A 269
HIS A 266
ASP A 246
 None
 1.20A 4rzvB-2ivfB:
undetectable		 4rzvB-2ivfB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj7 HEMOLYSIN II
REGULATORY PROTEIN

(Bacillus cereus) 		PF00440
(TetR_N) 		4 ILE A 108
PHE A  20
SER A 156
HIS A 152
 None
 1.33A 4rzvB-2jj7A:
undetectable		 4rzvB-2jj7A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kav SODIUM CHANNEL
PROTEIN TYPE 2
SUBUNIT ALPHA

(Homo sapiens) 		PF16905
(GPHH) 		4 ILE A1831
PHE A1795
SER A1819
ASP A1826
 None
 1.37A 4rzvB-2kavA:
undetectable		 4rzvB-2kavA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  51
SER A  30
HIS A   7
ASP A 122
 None
 1.16A 4rzvB-2lgzA:
undetectable		 4rzvB-2lgzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 128
SER A  30
HIS A   7
ASP A 122
 None
 1.33A 4rzvB-2lgzA:
undetectable		 4rzvB-2lgzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 ILE A  76
PHE A 256
HIS A  81
ASP A 135
 A3P  A 999 (-3.9A)
None
None
None
 1.43A 4rzvB-2oq2A:
undetectable		 4rzvB-2oq2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		4 ILE A 149
PHE A 242
SER A 165
ASP A 121
 None
 1.21A 4rzvB-2r9qA:
0.2		 4rzvB-2r9qA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 134
PHE A  26
SER A 130
HIS A 120
 None
None
None
NI  A 466 (-3.4A)
 1.37A 4rzvB-2r9zA:
undetectable		 4rzvB-2r9zA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		4 ILE A 180
PHE A 172
HIS A 403
ASP A 134
 None
 1.31A 4rzvB-2xa2A:
undetectable		 4rzvB-2xa2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 PHE A 322
SER A 355
HIS A 353
ASP A 415
 None
3ES  A1636 (-4.3A)
3ES  A1635 (-3.8A)
3ES  A1635 ( 3.9A)
 1.23A 4rzvB-2xy9A:
undetectable		 4rzvB-2xy9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 PHE A 300
SER A 333
HIS A 331
ASP A 393
 None
3ES  A1611 (-4.4A)
3ES  A1611 (-3.8A)
3ES  A1611 (-3.4A)
 1.26A 4rzvB-2xydA:
undetectable		 4rzvB-2xydA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 485
SER A 503
HIS A 553
ASP A 436
 None
 1.31A 4rzvB-3ahiA:
undetectable		 4rzvB-3ahiA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 485
SER A 503
HIS A 553
ASP A 436
 None
 1.26A 4rzvB-3ai7A:
undetectable		 4rzvB-3ai7A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayn RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		4 ILE A 314
PHE A  72
SER A 316
ASP A  80
 None
 1.37A 4rzvB-3aynA:
2.1		 4rzvB-3aynA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ILE A   5
PHE A 153
SER A 132
ASP A 118
 None
FAD  A 622 (-4.0A)
None
None
 1.42A 4rzvB-3cp8A:
undetectable		 4rzvB-3cp8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cql ENDOCHITINASE

(Carica papaya) 		PF00182
(Glyco_hydro_19) 		4 ILE A   6
PHE A  28
SER A   9
ASP A  32
 None
None
None
GOL  A 248 (-3.4A)
 1.42A 4rzvB-3cqlA:
undetectable		 4rzvB-3cqlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		4 ILE A 790
PHE A 754
SER A 763
ASP A 747
 None
None
SAH  A 854 ( 2.7A)
SAH  A 854 (-3.6A)
 1.26A 4rzvB-3gdhA:
undetectable		 4rzvB-3gdhA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 ILE P 292
PHE P 186
SER P 294
ASP P 280
 None
 1.35A 4rzvB-3hbuP:
undetectable		 4rzvB-3hbuP:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE

(Epichloe
festucae) 		PF00501
(AMP-binding) 		4 ILE A 415
SER A 413
HIS A 346
ASP A 340
 None
 1.39A 4rzvB-3iteA:
1.4		 4rzvB-3iteA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US5

(Plasmodium
falciparum) 		PF00333
(Ribosomal_S5)
PF01249
(Ribosomal_S21e)
PF03719
(Ribosomal_S5_C) 		4 ILE G  69
PHE G 258
SER G  66
HIS Z  29
 None
 1.09A 4rzvB-3j7aG:
undetectable		 4rzvB-3j7aG:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 ILE A1963
PHE A1941
SER A1958
ASP A1945
 None
 1.04A 4rzvB-3jb9A:
undetectable		 4rzvB-3jb9A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 ILE A 408
PHE A  64
HIS A  80
ASP A  69
 None
 1.41A 4rzvB-3k9dA:
undetectable		 4rzvB-3k9dA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmv ALPHA-L-ARABINOFURAN
OSIDASE B

(Ruminiclostridium
thermocellum) 		PF05270
(AbfB) 		4 ILE A 118
PHE A  28
SER A 110
ASP A  76
 None
FMT  A 162 (-3.8A)
None
CA  A 163 (-3.2A)
 1.42A 4rzvB-3kmvA:
undetectable		 4rzvB-3kmvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktb ARSENICAL RESISTANCE
OPERON TRANS-ACTING
REPRESSOR

(Bacteroides
vulgatus) 		PF06953
(ArsD) 		4 ILE A  41
PHE A   7
SER A  95
ASP A  79
 None
 1.19A 4rzvB-3ktbA:
undetectable		 4rzvB-3ktbA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 ILE A 103
PHE A 293
SER A 304
ASP A  97
 None
 1.44A 4rzvB-3kv4A:
undetectable		 4rzvB-3kv4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 ILE A 351
PHE A 285
SER A 469
ASP A 234
 CL  A  21 (-4.4A)
None
None
EDO  A   1 (-2.8A)
 1.33A 4rzvB-3kyaA:
undetectable		 4rzvB-3kyaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 ILE B  17
PHE B  64
SER B  20
ASP B 158
 None
SAM  B 301 (-3.7A)
None
None
 1.38A 4rzvB-3lcvB:
0.4		 4rzvB-3lcvB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		4 PHE A 149
SER A 132
HIS A 101
ASP A 154
 None
None
None
CA  A 323 ( 2.5A)
 1.32A 4rzvB-3m1rA:
undetectable		 4rzvB-3m1rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 335
PHE A 108
SER A 114
ASP A  41
 None
None
SEP  A 338 ( 2.9A)
None
 1.38A 4rzvB-3mvjA:
20.8		 4rzvB-3mvjA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opn PUTATIVE HEMOLYSIN

(Lactococcus
lactis) 		PF01728
(FtsJ) 		4 ILE A  96
PHE A 118
SER A  98
ASP A  86
 None
 1.36A 4rzvB-3opnA:
0.9		 4rzvB-3opnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ILE A  92
PHE A 100
SER A 114
ASP A 105
 None
 1.43A 4rzvB-3qivA:
undetectable		 4rzvB-3qivA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
NUCLEOTIDE EXCHANGE
FACTOR SIL1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70)
PF16782
(SIL1) 		4 ILE C 244
PHE C 155
SER C 239
ASP A 330
 None
 1.43A 4rzvB-3qmlC:
undetectable		 4rzvB-3qmlC:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 ILE A 298
PHE A  60
SER A 240
ASP A  39
 None
None
None
EPE  A 338 (-2.7A)
 1.43A 4rzvB-3qz4A:
undetectable		 4rzvB-3qz4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ILE A 193
PHE A 395
SER A 123
ASP A 209
 None
 1.37A 4rzvB-3vlaA:
undetectable		 4rzvB-3vlaA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0d ELASTASE INHIBITOR
AFUEI

(Aspergillus
fumigatus) 		PF11720
(Inhibitor_I78) 		4 ILE A  54
SER A  64
HIS A  66
ASP A  41
 None
 1.27A 4rzvB-3w0dA:
undetectable		 4rzvB-3w0dA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cit VANADIUM-DEPENDENT
HALOPEROXIDASE

(Zobellia
galactanivorans) 		PF01569
(PAP2) 		4 PHE A 375
SER A 361
HIS A 360
ASP A 383
 None
None
VO4  A1451 ( 3.9A)
None
 1.27A 4rzvB-4citA:
undetectable		 4rzvB-4citA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 ILE A1275
SER A1278
HIS A1252
ASP A1069
 None
None
MN  A1502 (-3.7A)
None
 1.15A 4rzvB-4fbqA:
undetectable		 4rzvB-4fbqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 4 ILE B 275
SER B 278
HIS B 252
ASP B  69
 None
None
MN  B 501 (-3.5A)
None
 1.22A 4rzvB-4fcxB:
undetectable		 4rzvB-4fcxB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		4 ILE A 136
PHE A  79
SER A 145
ASP A 169
 None
 1.17A 4rzvB-4h59A:
undetectable		 4rzvB-4h59A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
HYPOXIA INDUCIBLE
FACTOR 1-ALPHA

(Homo sapiens) 		PF08447
(PAS_3)
PF14598
(PAS_11) 		4 ILE A 324
PHE A 242
SER B 443
ASP B 377
 None
 0.97A 4rzvB-4h6jA:
undetectable		 4rzvB-4h6jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 115
PHE A 384
SER A 124
ASP A 235
 BHF  A 602 (-4.7A)
None
None
None
 1.26A 4rzvB-4i8vA:
undetectable		 4rzvB-4i8vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 340
PHE A 177
SER A 263
ASP A 169
 None
 1.41A 4rzvB-4jr7A:
20.4		 4rzvB-4jr7A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		4 ILE A 203
PHE A 265
SER A 199
ASP A 145
 None
 1.06A 4rzvB-4k05A:
undetectable		 4rzvB-4k05A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 ILE A 320
SER A 302
HIS A 244
ASP A 297
 None
 1.28A 4rzvB-4lgnA:
undetectable		 4rzvB-4lgnA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM

(Caldanaerobacter
subterraneus) 		PF01891
(CbiM) 		4 ILE A  69
PHE A  92
HIS A 190
ASP A 100
 None
 1.19A 4rzvB-4m5bA:
undetectable		 4rzvB-4m5bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mst CLASS I CHITINASE

(Hevea
brasiliensis) 		PF00182
(Glyco_hydro_19) 		4 ILE A  56
PHE A  78
SER A  59
ASP A  82
 None
 1.29A 4rzvB-4mstA:
undetectable		 4rzvB-4mstA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		4 ILE A 203
PHE A 220
SER A 206
ASP A 236
 None
 1.01A 4rzvB-4nj5A:
undetectable		 4rzvB-4nj5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 306
PHE A 250
HIS A 211
ASP A 231
 None
 1.39A 4rzvB-4uhiA:
undetectable		 4rzvB-4uhiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		4 ILE A 571
PHE A 596
HIS A 686
ASP A 644
 None
 1.40A 4rzvB-4wiwA:
undetectable		 4rzvB-4wiwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww3 RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		4 ILE A 314
PHE A  72
SER A 316
ASP A  80
 None
None
PLM  A 403 (-3.1A)
None
 1.37A 4rzvB-4ww3A:
2.0		 4rzvB-4ww3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yke MRE11

(Chaetomium
thermophilum) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 ILE A 266
SER A 269
HIS A 243
ASP A  61
 None
None
MN  A 601 (-3.5A)
None
 1.25A 4rzvB-4ykeA:
undetectable		 4rzvB-4ykeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ILE A   5
PHE A  25
SER A 106
ASP A 113
 None
None
SO4  A 806 (-2.6A)
None
 0.97A 4rzvB-4zlgA:
undetectable		 4rzvB-4zlgA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 PHE A 306
SER A 339
HIS A 337
ASP A 399
 None
None
MLT  A1615 (-3.8A)
None
 1.13A 4rzvB-5a2rA:
undetectable		 4rzvB-5a2rA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeu BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Paraburkholderia
xenovorans) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 135
PHE B 187
SER B 115
ASP B  39
 None
 1.18A 4rzvB-5aeuB:
undetectable		 4rzvB-5aeuB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 ILE A 517
PHE A  22
SER A 502
ASP A  25
 None
 1.41A 4rzvB-5ah5A:
undetectable		 4rzvB-5ah5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czj DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 ILE A 124
PHE A 300
HIS A 140
ASP A  77
 None
 1.38A 4rzvB-5czjA:
undetectable		 4rzvB-5czjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 ILE A 299
PHE A 160
SER A  66
ASP A 435
 None
 1.31A 4rzvB-5dxfA:
undetectable		 4rzvB-5dxfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		4 ILE A  60
SER A  71
HIS A  96
ASP A 122
 None
SAH  A 400 ( 4.8A)
None
None
 1.23A 4rzvB-5f2oA:
undetectable		 4rzvB-5f2oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftz CHITIN BINDING
PROTEIN

(Streptomyces
lividans) 		PF03067
(LPMO_10) 		4 ILE A  77
PHE A 112
SER A  79
ASP A 198
 None
 1.44A 4rzvB-5ftzA:
undetectable		 4rzvB-5ftzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 202
PHE A 272
SER A 445
HIS A 447
 None
 1.25A 4rzvB-5h80A:
0.8		 4rzvB-5h80A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 ILE A 164
SER A  89
HIS A 141
ASP A 274
 None
 1.35A 4rzvB-5hxaA:
undetectable		 4rzvB-5hxaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2

(Homo sapiens) 		PF05609
(LAP1C) 		4 ILE B 328
PHE B 280
SER B 326
ASP B 391
 None
 1.41A 4rzvB-5j1sB:
undetectable		 4rzvB-5j1sB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 ILE A  86
PHE A 310
SER A 218
HIS A  90
 None
 1.09A 4rzvB-5jodA:
undetectable		 4rzvB-5jodA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lg4 PROTEIN SSO2

(Saccharomyces
cerevisiae) 		PF00804
(Syntaxin) 		4 ILE A  57
PHE A 218
SER A  89
ASP A 137
 None
 0.93A 4rzvB-5lg4A:
undetectable		 4rzvB-5lg4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE A  38
PHE A  11
HIS A  58
ASP A 777
 None
 1.38A 4rzvB-5m2nA:
undetectable		 4rzvB-5m2nA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 685
PHE A 490
HIS A 682
ASP A 515
 None
 1.15A 4rzvB-5nd5A:
undetectable		 4rzvB-5nd5A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		4 ILE A 157
SER A  82
HIS A 134
ASP A 267
 None
 1.35A 4rzvB-5tvgA:
undetectable		 4rzvB-5tvgA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqd DUMPY: SHORTER THAN
WILD-TYPE

(Caenorhabditis
elegans) 		no annotation 4 ILE A1408
PHE A1586
SER A1403
ASP A1454
 PG0  A1703 (-4.2A)
None
None
FE2  A1702 (-2.6A)
 1.32A 4rzvB-5uqdA:
undetectable		 4rzvB-5uqdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 ILE A 165
SER A  90
HIS A 142
ASP A 279
 G6P  A 502 (-4.8A)
None
G6P  A 502 (-4.7A)
None
 1.27A 4rzvB-5v0tA:
undetectable		 4rzvB-5v0tA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viq MONOMERIC
NEAR-INFRARED
FLUORESCENT PROTEIN
MIRFP709

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 ILE A  79
PHE A  57
SER A  41
HIS A  45
 None
 1.40A 4rzvB-5viqA:
undetectable		 4rzvB-5viqA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 4 ILE A 164
SER A 147
HIS A 321
ASP A  20
 None
 1.23A 4rzvB-5wa3A:
undetectable		 4rzvB-5wa3A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		4 ILE A 148
PHE A1093
HIS A1102
ASP A1097
 None
 1.36A 4rzvB-5xeiA:
undetectable		 4rzvB-5xeiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		4 PHE B 231
SER B 177
HIS B 178
ASP B 208
 None
 1.33A 4rzvB-5xeqB:
undetectable		 4rzvB-5xeqB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF10588
(NADH-G_4Fe-4S_3)
PF13459
(Fer4_15)
PF13510
(Fer2_4) 		4 PHE B 227
SER D 186
HIS D  88
ASP C 189
 None
 1.42A 4rzvB-5xfaB:
undetectable		 4rzvB-5xfaB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 ILE A 158
PHE A 121
SER A 131
HIS A 133
 None
 1.28A 4rzvB-5y30A:
undetectable		 4rzvB-5y30A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 ILE A 479
PHE A 502
SER A 410
ASP A 401
 None
NAG  A1016 (-4.5A)
None
None
 1.34A 4rzvB-6bv2A:
undetectable		 4rzvB-6bv2A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9w EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TRANSPORTER
PROTEIN LSM14
HOMOLOG A

(Homo sapiens) 		no annotation 4 ILE A  72
PHE A  62
SER A  34
ASP B 979
 None
 1.39A 4rzvB-6f9wA:
undetectable		 4rzvB-6f9wA:
17.72