SIMILAR PATTERNS OF AMINO ACIDS FOR 4RZV_B_032B801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 416
ALA A 428
LYS A 430
THR A 474
PHE A 540
GLY A 541
 None
 0.80A 4rzvB-1k2pA:
28.2		 4rzvB-1k2pA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
THR A 266
SER A 273
PHE A 333
 None
 0.88A 4rzvB-1k9aA:
27.1		 4rzvB-1k9aA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 VAL A 219
ALA A 230
LYS A 232
LEU A 260
SER A 287
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.2A)
None
 0.70A 4rzvB-1py5A:
25.2		 4rzvB-1py5A:
30.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sng COG4826: SERINE
PROTEASE INHIBITOR

(Thermobifida
fusca) 		PF00079
(Serpin) 		6 VAL A 296
ALA A 284
THR A  54
SER A 290
GLY A  49
GLY A  44
 None
None
None
None
None
CAF  A  41 ( 3.6A)
 1.33A 4rzvB-1sngA:
undetectable		 4rzvB-1sngA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
 0.31A 4rzvB-1t46A:
22.9		 4rzvB-1t46A:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
CYH A 108
SER A 111
GLY A 168
GLY A 171
 None
 1.38A 4rzvB-1u5qA:
23.7		 4rzvB-1u5qA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
LYS A  57
CYH A 108
SER A 111
GLY A 171
 None
 1.31A 4rzvB-1u5qA:
23.7		 4rzvB-1u5qA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  23
ALA A  36
LYS A  38
CYH A  87
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
 0.80A 4rzvB-1zltA:
15.9		 4rzvB-1zltA:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B 281
LYS B 296
CYH B 369
PHE B 421
GLY B 431
GLY B 434
 None
 1.35A 4rzvB-2a1aB:
21.9		 4rzvB-2a1aB:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B 281
LYS B 296
CYH B 369
PHE B 421
GLY B 431
PHE B 433
 None
 1.01A 4rzvB-2a1aB:
21.9		 4rzvB-2a1aB:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL X  25
ALA X  37
LYS X  39
THR X  82
SER X  89
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 ( 4.0A)
 0.71A 4rzvB-2dq7X:
26.9		 4rzvB-2dq7X:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
CYH A 108
SER A 111
GLY A 168
GLY A 171
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-4.0A)
STU  A 400 (-3.3A)
None
None
 1.40A 4rzvB-2gcdA:
24.9		 4rzvB-2gcdA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
LYS A 295
THR A 338
SER A 345
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
 0.79A 4rzvB-2h8hA:
28.8		 4rzvB-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
THR A 338
SER A 345
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
None
 0.56A 4rzvB-2h8hA:
28.8		 4rzvB-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
THR A 338
SER A 345
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.7A)
None
 0.78A 4rzvB-2hckA:
28.1		 4rzvB-2hckA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
LYS A 273
THR A 316
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
 0.77A 4rzvB-2hk5A:
25.9		 4rzvB-2hk5A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
LYS A 273
THR A 316
SER A 323
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
 0.63A 4rzvB-2hk5A:
25.9		 4rzvB-2hk5A:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  63
ALA A  76
LYS A  78
LEU A 108
SER A 131
 None
 0.81A 4rzvB-2hw6A:
19.3		 4rzvB-2hw6A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
LYS A  49
PHE A 159
GLY A 170
GLY A 173
 None
 1.42A 4rzvB-2i6lA:
22.3		 4rzvB-2i6lA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 VAL A 436
ALA A 452
LYS A 454
CYH A 502
PHE A 565
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
 0.84A 4rzvB-2j0jA:
27.9		 4rzvB-2j0jA:
16.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 566
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.1A)
None
 0.67A 4rzvB-2jkmA:
26.8		 4rzvB-2jkmA:
30.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
LYS A 616
THR A 663
CYH A 666
GLY A 795
 None
 0.75A 4rzvB-2ogvA:
18.4		 4rzvB-2ogvA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.85A 4rzvB-2qluA:
25.8		 4rzvB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
SER A 272
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.61A 4rzvB-2qluA:
25.8		 4rzvB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 204
ALA A 215
LYS A 217
SER A 272
GLY A 341
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
 0.83A 4rzvB-2qluA:
25.8		 4rzvB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
ALA A 651
LYS A 653
THR A 699
SER A 706
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.73A 4rzvB-2qobA:
25.9		 4rzvB-2qobA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq7 ATP SYNTHASE EPSILON
CHAIN

(Spinacia
oleracea;
Thermosynechococcus
elongatus) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		5 VAL A  74
ALA A  67
LEU A  31
THR A  42
GLY A  32
 None
 0.83A 4rzvB-2rq7A:
undetectable		 4rzvB-2rq7A:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
ALA A 651
LYS A 653
THR A 699
SER A 706
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 4.5A)
 0.75A 4rzvB-2xyuA:
26.6		 4rzvB-2xyuA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 313
ALA A 326
CYH A 379
SER A 383
PHE A 433
GLY A 462
GLY A 465
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-4.0A)
None
None
 1.20A 4rzvB-2z2wA:
22.4		 4rzvB-2z2wA:
27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 261
ALA A 273
LYS A 275
THR A 319
SER A 326
PHE A 386
 None
 0.98A 4rzvB-2zv7A:
26.3		 4rzvB-2zv7A:
33.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
THR A 266
SER A 273
PHE A 333
 None
 0.88A 4rzvB-3d7uA:
27.8		 4rzvB-3d7uA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 VAL A  50
ALA A  40
THR A  38
GLY A 134
GLY A   8
 None
FAD  A 444 ( 4.1A)
FAD  A 444 (-4.5A)
FAD  A 444 (-3.2A)
FAD  A 444 (-3.3A)
 0.67A 4rzvB-3g5sA:
undetectable		 4rzvB-3g5sA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 VAL A  90
ALA A 103
LYS A 105
PHE A 221
GLY A 222
 None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 (-4.1A)
GOL  A 602 ( 3.7A)
 0.74A 4rzvB-3hztA:
22.1		 4rzvB-3hztA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 704
LYS A 723
THR A 768
SER A 775
PHE A 834
 ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
ANP  A   1 ( 4.8A)
None
None
 0.85A 4rzvB-3kexA:
27.5		 4rzvB-3kexA:
29.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 649
ALA A 665
LYS A 667
THR A 713
PHE A 779
 None
 0.83A 4rzvB-3kulA:
24.2		 4rzvB-3kulA:
33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 649
ALA A 665
LYS A 667
THR A 713
SER A 720
 None
 0.78A 4rzvB-3kulA:
24.2		 4rzvB-3kulA:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
SER A 286
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
 0.63A 4rzvB-3mdyA:
26.0		 4rzvB-3mdyA:
29.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
SER A 284
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
 0.74A 4rzvB-3my0A:
25.1		 4rzvB-3my0A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
CYH A 424
SER A 427
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
 1.05A 4rzvB-3omvA:
33.1		 4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 363
ALA A 373
LYS A 375
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
 0.95A 4rzvB-3omvA:
33.1		 4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 363
ALA A 373
LYS A 375
LEU A 406
THR A 421
TRP A 423
CYH A 424
SER A 428
PHE A 475
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
SM5  A   1 (-3.0A)
 1.00A 4rzvB-3omvA:
33.1		 4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 363
ALA A 373
LYS A 375
TRP A 423
CYH A 424
PHE A 475
GLY A 485
GLY A 488
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
 1.30A 4rzvB-3omvA:
33.1		 4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 VAL A 565
ALA A 576
LYS A 578
THR A 625
SER A 632
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 ( 4.3A)
None
 1.00A 4rzvB-3ppzA:
29.3		 4rzvB-3ppzA:
36.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
SER A 274
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.97A 4rzvB-3q4tA:
25.4		 4rzvB-3q4tA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
GLY B 955
 None
 1.26A 4rzvB-3qd2B:
22.3		 4rzvB-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
PHE B 954
 None
 1.02A 4rzvB-3qd2B:
22.3		 4rzvB-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
GLY A 196
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 1.36A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 0.90A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
LYS A  82
CYH A 133
SER A 137
PHE A 183
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
 0.72A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
GLY A 205
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 1.36A 4rzvB-4b6lA:
23.2		 4rzvB-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 0.97A 4rzvB-4b6lA:
23.2		 4rzvB-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
LYS A  91
CYH A 142
SER A 146
PHE A 192
GLY A 202
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.65A 4rzvB-4b6lA:
23.2		 4rzvB-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
SER A 290
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
 0.70A 4rzvB-4c02A:
24.6		 4rzvB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  23
ALA A  36
LYS A  38
CYH A  89
PHE A 158
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 (-4.1A)
None
 0.85A 4rzvB-4eutA:
20.0		 4rzvB-4eutA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
CYH A  89
SER A  93
PHE A 158
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.1A)
BX7  A 401 ( 4.7A)
None
 1.11A 4rzvB-4euuA:
18.8		 4rzvB-4euuA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
 0.99A 4rzvB-4g34A:
23.3		 4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
CYH A 890
PHE A 943
PHE A 955
GLY A 956
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
None
 0.80A 4rzvB-4g34A:
23.3		 4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 955
GLY A 956
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
 0.73A 4rzvB-4g34A:
23.3		 4rzvB-4g34A:
28.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 863
ALA A 880
LYS A 882
SER A 936
GLY A 993
GLY A 996
 None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
 1.45A 4rzvB-4gl9A:
7.8		 4rzvB-4gl9A:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 863
ALA A 880
LYS A 882
SER A 936
GLY A 993
PHE A 995
 None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
 1.02A 4rzvB-4gl9A:
7.8		 4rzvB-4gl9A:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 VAL A 140
ALA A 156
THR A 205
SER A 212
GLY A 269
PHE A 271
 None
 0.84A 4rzvB-4hzsA:
27.1		 4rzvB-4hzsA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
LYS A 111
CYH A 162
SER A 166
PHE A 212
GLY A 222
GLY A 225
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
None
1C7  A 401 (-4.0A)
None
None
 1.42A 4rzvB-4i6fA:
22.1		 4rzvB-4i6fA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
LYS A 111
CYH A 162
SER A 166
PHE A 212
GLY A 222
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
None
1C7  A 401 (-4.0A)
None
None
 1.04A 4rzvB-4i6fA:
22.1		 4rzvB-4i6fA:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
1G0  A 401 ( 4.8A)
 0.87A 4rzvB-4id7A:
26.4		 4rzvB-4id7A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 140
ALA A 156
LYS A 158
THR A 205
SER A 212
GLY A 269
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.3A)
None
 1.06A 4rzvB-4id7A:
26.4		 4rzvB-4id7A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 ALA A 110
SER A 221
GLY A 360
PHE A 361
GLY A 333
 None
 0.81A 4rzvB-4iviA:
undetectable		 4rzvB-4iviA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		7 ALA A  66
LYS A  68
CYH A 119
SER A 123
PHE A 169
GLY A 179
PHE A 181
 None
 1.18A 4rzvB-4j7bA:
23.1		 4rzvB-4j7bA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A  23
ALA A  36
LYS A  38
CYH A  89
SER A  93
PHE A 158
GLY A 159
 None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
None
None
None
 0.88A 4rzvB-4jlcA:
20.8		 4rzvB-4jlcA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  26
ALA A  39
LEU A  73
CYH A  92
PHE A 155
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 (-4.5A)
None
 0.71A 4rzvB-4jxfA:
19.0		 4rzvB-4jxfA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  26
ALA A  39
LYS A  41
LEU A  73
CYH A  92
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 (-4.5A)
 0.75A 4rzvB-4jxfA:
19.0		 4rzvB-4jxfA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  41
ALA A  54
LYS A  56
CYH A 102
SER A 106
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.0A)
None
 0.82A 4rzvB-4lg4A:
23.7		 4rzvB-4lg4A:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
ALA A  49
LEU A  74
THR A  95
SER A 102
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
ANP  A 401 (-3.6A)
None
 0.91A 4rzvB-4m69A:
28.0		 4rzvB-4m69A:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 0.90A 4rzvB-4m69A:
28.0		 4rzvB-4m69A:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B  38
ALA B  51
LYS B  53
SER B 106
PHE B 163
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 (-3.4A)
None
 0.85A 4rzvB-4o27B:
24.0		 4rzvB-4o27B:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.73A 4rzvB-4o38A:
20.1		 4rzvB-4o38A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4our PHYTOCHROME B

(Arabidopsis
thaliana) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ALA B 203
LEU B 175
SER B 194
PHE B 167
PHE B 128
 None
 0.81A 4rzvB-4ourB:
undetectable		 4rzvB-4ourB:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
LYS A  37
THR A  81
SER A  88
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-4.3A)
None
 1.02A 4rzvB-4ueuA:
26.5		 4rzvB-4ueuA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
LYS A 490
THR A 539
SER A 546
PHE A 607
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-2.8A)
None
None
 0.91A 4rzvB-4yffA:
24.9		 4rzvB-4yffA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 492
ALA A 512
LYS A 514
PHE A 642
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-3.7A)
EDO  A1766 (-3.6A)
 0.65A 4rzvB-5a46A:
26.8		 4rzvB-5a46A:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  39
ALA A  52
LYS A  54
SER A 112
PHE A 172
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
SER  A 112 (-0.0A)
PHE  A 172 ( 1.3A)
 0.65A 4rzvB-5d7aA:
25.4		 4rzvB-5d7aA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 258
ALA A 275
LYS A 277
LEU A 305
THR A 325
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
 0.43A 4rzvB-5e8yA:
24.7		 4rzvB-5e8yA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
LYS A 930
SER A 985
GLY A1040
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 ( 4.9A)
None
 1.08A 4rzvB-5f1zA:
26.8		 4rzvB-5f1zA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 VAL A 471
ALA A 481
LYS A 483
LEU A 514
THR A 529
TRP A 531
CYH A 532
SER A 536
PHE A 583
GLY A 593
PHE A 595
GLY A 596
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
None
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
5XJ  A 801 (-3.7A)
5XJ  A 801 (-3.7A)
 0.82A 4rzvB-5fd2A:
36.5		 4rzvB-5fd2A:
93.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.35A 4rzvB-5grnA:
20.8		 4rzvB-5grnA:
28.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A  30
ALA A  43
LYS A  45
THR A  82
SER A  89
PHE A 152
GLY A 153
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
None
032  A 401 (-4.1A)
032  A 401 (-3.6A)
 0.63A 4rzvB-5hesA:
21.6		 4rzvB-5hesA:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1092
ALA A1108
LEU A1140
PHE A1223
GLY A1224
 63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
None
None
 0.63A 4rzvB-5horA:
25.9		 4rzvB-5horA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.82A 4rzvB-5j5tA:
22.7		 4rzvB-5j5tA:
25.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL B 680
ALA B 690
THR B 739
CYH B 742
PHE B 804
 6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
6U7  B1001 (-3.8A)
 0.80A 4rzvB-5kkrB:
23.5		 4rzvB-5kkrB:
36.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 250
GLY A 253
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 1.17A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 250
PHE A 252
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 0.88A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 124
ALA A 137
LYS A 139
THR A 187
CYH A 190
GLY A 253
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 1.11A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 124
ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 253
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
 0.96A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 124
ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
 0.91A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 226
ALA A 239
CYH A 292
PHE A 346
GLY A 379
GLY A 382
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
None
 1.17A 4rzvB-5vdkA:
22.1		 4rzvB-5vdkA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 226
ALA A 239
CYH A 292
SER A 296
PHE A 346
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
None
8X7  A 501 (-3.7A)
None
 0.91A 4rzvB-5vdkA:
22.1		 4rzvB-5vdkA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
SER A 102
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
None
 0.83A 4rzvB-5w5jA:
26.4		 4rzvB-5w5jA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 VAL A 899
ALA A 917
LEU A 947
THR A 963
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
 0.58A 4rzvB-5wnoA:
27.6		 4rzvB-5wnoA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 VAL A  41
ALA A  54
CYH A 102
SER A 106
PHE A 165
GLY A 166
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-4.2A)
ANP  A 501 (-2.4A)
None
None
 0.78A 4rzvB-6ao5A:
24.1		 4rzvB-6ao5A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 VAL A 226
ALA A 237
LYS A 239
SER A 295
GLY A 357
GLY A 360
 None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.6A)
DL1  A 601 ( 4.8A)
None
 1.10A 4rzvB-6bfnA:
24.6		 4rzvB-6bfnA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 VAL A 889
ALA A 906
LYS A 908
SER A 963
GLY A1020
GLY A1023
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-3.3A)
None
MG  A1203 ( 4.7A)
 1.39A 4rzvB-6c7yA:
13.5		 4rzvB-6c7yA:
15.28