SIMILAR PATTERNS OF AMINO ACIDS FOR 4RZV_B_032B801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 416
ALA A 428
LYS A 430
THR A 474
PHE A 540
GLY A 541
 None
 0.80A 4rzvB-1k2pA:
28.2		 4rzvB-1k2pA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
THR A 266
SER A 273
PHE A 333
 None
 0.88A 4rzvB-1k9aA:
27.1		 4rzvB-1k9aA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 VAL A 219
ALA A 230
LYS A 232
LEU A 260
SER A 287
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-4.2A)
None
 0.70A 4rzvB-1py5A:
25.2		 4rzvB-1py5A:
30.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sng COG4826: SERINE
PROTEASE INHIBITOR

(Thermobifida
fusca) 		PF00079
(Serpin) 		6 VAL A 296
ALA A 284
THR A  54
SER A 290
GLY A  49
GLY A  44
 None
None
None
None
None
CAF  A  41 ( 3.6A)
 1.33A 4rzvB-1sngA:
undetectable		 4rzvB-1sngA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
 0.31A 4rzvB-1t46A:
22.9		 4rzvB-1t46A:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
CYH A 108
SER A 111
GLY A 168
GLY A 171
 None
 1.38A 4rzvB-1u5qA:
23.7		 4rzvB-1u5qA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
LYS A  57
CYH A 108
SER A 111
GLY A 171
 None
 1.31A 4rzvB-1u5qA:
23.7		 4rzvB-1u5qA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  23
ALA A  36
LYS A  38
CYH A  87
PHE A 149
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
 0.80A 4rzvB-1zltA:
15.9		 4rzvB-1zltA:
26.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B 281
LYS B 296
CYH B 369
PHE B 421
GLY B 431
GLY B 434
 None
 1.35A 4rzvB-2a1aB:
21.9		 4rzvB-2a1aB:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B 281
LYS B 296
CYH B 369
PHE B 421
GLY B 431
PHE B 433
 None
 1.01A 4rzvB-2a1aB:
21.9		 4rzvB-2a1aB:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL X  25
ALA X  37
LYS X  39
THR X  82
SER X  89
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 ( 4.0A)
 0.71A 4rzvB-2dq7X:
26.9		 4rzvB-2dq7X:
33.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
CYH A 108
SER A 111
GLY A 168
GLY A 171
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-4.0A)
STU  A 400 (-3.3A)
None
None
 1.40A 4rzvB-2gcdA:
24.9		 4rzvB-2gcdA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
LYS A 295
THR A 338
SER A 345
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
 0.79A 4rzvB-2h8hA:
28.8		 4rzvB-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
THR A 338
SER A 345
PHE A 405
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
None
 0.56A 4rzvB-2h8hA:
28.8		 4rzvB-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 281
ALA A 293
THR A 338
SER A 345
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.7A)
None
 0.78A 4rzvB-2hckA:
28.1		 4rzvB-2hckA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
LYS A 273
THR A 316
PHE A 383
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
 0.77A 4rzvB-2hk5A:
25.9		 4rzvB-2hk5A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 259
ALA A 271
LYS A 273
THR A 316
SER A 323
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
 0.63A 4rzvB-2hk5A:
25.9		 4rzvB-2hk5A:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  63
ALA A  76
LYS A  78
LEU A 108
SER A 131
 None
 0.81A 4rzvB-2hw6A:
19.3		 4rzvB-2hw6A:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
LYS A  49
PHE A 159
GLY A 170
GLY A 173
 None
 1.42A 4rzvB-2i6lA:
22.3		 4rzvB-2i6lA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 VAL A 436
ALA A 452
LYS A 454
CYH A 502
PHE A 565
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
 0.84A 4rzvB-2j0jA:
27.9		 4rzvB-2j0jA:
16.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 566
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.1A)
None
 0.67A 4rzvB-2jkmA:
26.8		 4rzvB-2jkmA:
30.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
LYS A 616
THR A 663
CYH A 666
GLY A 795
 None
 0.75A 4rzvB-2ogvA:
18.4		 4rzvB-2ogvA:
28.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.85A 4rzvB-2qluA:
25.8		 4rzvB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
SER A 272
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
 0.61A 4rzvB-2qluA:
25.8		 4rzvB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 204
ALA A 215
LYS A 217
SER A 272
GLY A 341
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
 0.83A 4rzvB-2qluA:
25.8		 4rzvB-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
ALA A 651
LYS A 653
THR A 699
SER A 706
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
 0.73A 4rzvB-2qobA:
25.9		 4rzvB-2qobA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rq7 ATP SYNTHASE EPSILON
CHAIN

(Spinacia
oleracea;
Thermosynechococcus
elongatus) 		PF00401
(ATP-synt_DE)
PF02823
(ATP-synt_DE_N) 		5 VAL A  74
ALA A  67
LEU A  31
THR A  42
GLY A  32
 None
 0.83A 4rzvB-2rq7A:
undetectable		 4rzvB-2rq7A:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 635
ALA A 651
LYS A 653
THR A 699
SER A 706
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 4.5A)
 0.75A 4rzvB-2xyuA:
26.6		 4rzvB-2xyuA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 313
ALA A 326
CYH A 379
SER A 383
PHE A 433
GLY A 462
GLY A 465
 770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
None
770  A 901 (-4.0A)
None
None
 1.20A 4rzvB-2z2wA:
22.4		 4rzvB-2z2wA:
27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 261
ALA A 273
LYS A 275
THR A 319
SER A 326
PHE A 386
 None
 0.98A 4rzvB-2zv7A:
26.3		 4rzvB-2zv7A:
33.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
LYS A 222
THR A 266
SER A 273
PHE A 333
 None
 0.88A 4rzvB-3d7uA:
27.8		 4rzvB-3d7uA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 VAL A  50
ALA A  40
THR A  38
GLY A 134
GLY A   8
 None
FAD  A 444 ( 4.1A)
FAD  A 444 (-4.5A)
FAD  A 444 (-3.2A)
FAD  A 444 (-3.3A)
 0.67A 4rzvB-3g5sA:
undetectable		 4rzvB-3g5sA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 VAL A  90
ALA A 103
LYS A 105
PHE A 221
GLY A 222
 None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 (-4.1A)
GOL  A 602 ( 3.7A)
 0.74A 4rzvB-3hztA:
22.1		 4rzvB-3hztA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 704
LYS A 723
THR A 768
SER A 775
PHE A 834
 ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
ANP  A   1 ( 4.8A)
None
None
 0.85A 4rzvB-3kexA:
27.5		 4rzvB-3kexA:
29.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 649
ALA A 665
LYS A 667
THR A 713
PHE A 779
 None
 0.83A 4rzvB-3kulA:
24.2		 4rzvB-3kulA:
33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 VAL A 649
ALA A 665
LYS A 667
THR A 713
SER A 720
 None
 0.78A 4rzvB-3kulA:
24.2		 4rzvB-3kulA:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
SER A 286
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
 0.63A 4rzvB-3mdyA:
26.0		 4rzvB-3mdyA:
29.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
SER A 284
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
 0.74A 4rzvB-3my0A:
25.1		 4rzvB-3my0A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 363
ALA A 373
LEU A 406
THR A 421
TRP A 423
CYH A 424
SER A 427
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
 1.05A 4rzvB-3omvA:
33.1		 4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 363
ALA A 373
LYS A 375
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
 0.95A 4rzvB-3omvA:
33.1		 4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 363
ALA A 373
LYS A 375
LEU A 406
THR A 421
TRP A 423
CYH A 424
SER A 428
PHE A 475
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
None
SM5  A   1 (-3.0A)
 1.00A 4rzvB-3omvA:
33.1		 4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 363
ALA A 373
LYS A 375
TRP A 423
CYH A 424
PHE A 475
GLY A 485
GLY A 488
 SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
None
 1.30A 4rzvB-3omvA:
33.1		 4rzvB-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 VAL A 565
ALA A 576
LYS A 578
THR A 625
SER A 632
PHE A 695
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 ( 4.3A)
None
 1.00A 4rzvB-3ppzA:
29.3		 4rzvB-3ppzA:
36.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
SER A 274
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.97A 4rzvB-3q4tA:
25.4		 4rzvB-3q4tA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
GLY B 955
 None
 1.26A 4rzvB-3qd2B:
22.3		 4rzvB-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 952
PHE B 954
 None
 1.02A 4rzvB-3qd2B:
22.3		 4rzvB-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
GLY A 196
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 1.36A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
LYS A  82
CYH A 133
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
None
 0.90A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
LYS A  82
CYH A 133
SER A 137
PHE A 183
GLY A 193
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
 0.72A 4rzvB-4a4lA:
23.7		 4rzvB-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
GLY A 205
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 1.36A 4rzvB-4b6lA:
23.2		 4rzvB-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 0.97A 4rzvB-4b6lA:
23.2		 4rzvB-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
LYS A  91
CYH A 142
SER A 146
PHE A 192
GLY A 202
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.65A 4rzvB-4b6lA:
23.2		 4rzvB-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
SER A 290
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
 0.70A 4rzvB-4c02A:
24.6		 4rzvB-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  23
ALA A  36
LYS A  38
CYH A  89
PHE A 158
 BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
BX7  A 401 (-4.1A)
None
 0.85A 4rzvB-4eutA:
20.0		 4rzvB-4eutA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
CYH A  89
SER A  93
PHE A 158
 BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
BX7  A 401 (-4.1A)
BX7  A 401 ( 4.7A)
None
 1.11A 4rzvB-4euuA:
18.8		 4rzvB-4euuA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
CYH A 890
PHE A 943
GLY A 953
PHE A 955
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 (-4.6A)
924  A1101 ( 4.4A)
 0.99A 4rzvB-4g34A:
23.3		 4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
CYH A 890
PHE A 943
PHE A 955
GLY A 956
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
None
 0.80A 4rzvB-4g34A:
23.3		 4rzvB-4g34A:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 955
GLY A 956
 924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
 0.73A 4rzvB-4g34A:
23.3		 4rzvB-4g34A:
28.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 863
ALA A 880
LYS A 882
SER A 936
GLY A 993
GLY A 996
 None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
 1.45A 4rzvB-4gl9A:
7.8		 4rzvB-4gl9A:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 863
ALA A 880
LYS A 882
SER A 936
GLY A 993
PHE A 995
 None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
None
 1.02A 4rzvB-4gl9A:
7.8		 4rzvB-4gl9A:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 VAL A 140
ALA A 156
THR A 205
SER A 212
GLY A 269
PHE A 271
 None
 0.84A 4rzvB-4hzsA:
27.1		 4rzvB-4hzsA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
LYS A 111
CYH A 162
SER A 166
PHE A 212
GLY A 222
GLY A 225
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
None
1C7  A 401 (-4.0A)
None
None
 1.42A 4rzvB-4i6fA:
22.1		 4rzvB-4i6fA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
LYS A 111
CYH A 162
SER A 166
PHE A 212
GLY A 222
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
1C7  A 401 (-4.1A)
None
1C7  A 401 (-4.0A)
None
None
 1.04A 4rzvB-4i6fA:
22.1		 4rzvB-4i6fA:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 140
ALA A 156
LYS A 158
THR A 205
GLY A 269
PHE A 271
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
None
1G0  A 401 ( 4.8A)
 0.87A 4rzvB-4id7A:
26.4		 4rzvB-4id7A:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 140
ALA A 156
LYS A 158
THR A 205
SER A 212
GLY A 269
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.3A)
None
 1.06A 4rzvB-4id7A:
26.4		 4rzvB-4id7A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 ALA A 110
SER A 221
GLY A 360
PHE A 361
GLY A 333
 None
 0.81A 4rzvB-4iviA:
undetectable		 4rzvB-4iviA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		7 ALA A  66
LYS A  68
CYH A 119
SER A 123
PHE A 169
GLY A 179
PHE A 181
 None
 1.18A 4rzvB-4j7bA:
23.1		 4rzvB-4j7bA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A  23
ALA A  36
LYS A  38
CYH A  89
SER A  93
PHE A 158
GLY A 159
 None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
None
None
None
 0.88A 4rzvB-4jlcA:
20.8		 4rzvB-4jlcA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  26
ALA A  39
LEU A  73
CYH A  92
PHE A 155
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
None
631  A 301 (-4.5A)
None
 0.71A 4rzvB-4jxfA:
19.0		 4rzvB-4jxfA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  26
ALA A  39
LYS A  41
LEU A  73
CYH A  92
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 (-4.5A)
 0.75A 4rzvB-4jxfA:
19.0		 4rzvB-4jxfA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  41
ALA A  54
LYS A  56
CYH A 102
SER A 106
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.0A)
None
 0.82A 4rzvB-4lg4A:
23.7		 4rzvB-4lg4A:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
ALA A  49
LEU A  74
THR A  95
SER A 102
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
None
ANP  A 401 (-3.8A)
ANP  A 401 (-3.6A)
None
 0.91A 4rzvB-4m69A:
28.0		 4rzvB-4m69A:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
 0.90A 4rzvB-4m69A:
28.0		 4rzvB-4m69A:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL B  38
ALA B  51
LYS B  53
SER B 106
PHE B 163
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
ADP  B 500 (-3.4A)
None
 0.85A 4rzvB-4o27B:
24.0		 4rzvB-4o27B:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
 0.73A 4rzvB-4o38A:
20.1		 4rzvB-4o38A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4our PHYTOCHROME B

(Arabidopsis
thaliana) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ALA B 203
LEU B 175
SER B 194
PHE B 167
PHE B 128
 None
 0.81A 4rzvB-4ourB:
undetectable		 4rzvB-4ourB:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
LYS A  37
THR A  81
SER A  88
PHE A 148
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-4.3A)
None
 1.02A 4rzvB-4ueuA:
26.5		 4rzvB-4ueuA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
LYS A 490
THR A 539
SER A 546
PHE A 607
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-2.8A)
None
None
 0.91A 4rzvB-4yffA:
24.9		 4rzvB-4yffA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 492
ALA A 512
LYS A 514
PHE A 642
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-3.7A)
EDO  A1766 (-3.6A)
 0.65A 4rzvB-5a46A:
26.8		 4rzvB-5a46A:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  39
ALA A  52
LYS A  54
SER A 112
PHE A 172
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
SER  A 112 (-0.0A)
PHE  A 172 ( 1.3A)
 0.65A 4rzvB-5d7aA:
25.4		 4rzvB-5d7aA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 258
ALA A 275
LYS A 277
LEU A 305
THR A 325
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
 0.43A 4rzvB-5e8yA:
24.7		 4rzvB-5e8yA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
LYS A 930
SER A 985
GLY A1040
PHE A1042
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 ( 4.9A)
None
 1.08A 4rzvB-5f1zA:
26.8		 4rzvB-5f1zA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 VAL A 471
ALA A 481
LYS A 483
LEU A 514
THR A 529
TRP A 531
CYH A 532
SER A 536
PHE A 583
GLY A 593
PHE A 595
GLY A 596
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
None
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
5XJ  A 801 (-3.7A)
5XJ  A 801 (-3.7A)
 0.82A 4rzvB-5fd2A:
36.5		 4rzvB-5fd2A:
93.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
 0.35A 4rzvB-5grnA:
20.8		 4rzvB-5grnA:
28.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A  30
ALA A  43
LYS A  45
THR A  82
SER A  89
PHE A 152
GLY A 153
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
None
032  A 401 (-4.1A)
032  A 401 (-3.6A)
 0.63A 4rzvB-5hesA:
21.6		 4rzvB-5hesA:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A1092
ALA A1108
LEU A1140
PHE A1223
GLY A1224
 63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
None
None
 0.63A 4rzvB-5horA:
25.9		 4rzvB-5horA:
29.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
 0.82A 4rzvB-5j5tA:
22.7		 4rzvB-5j5tA:
25.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL B 680
ALA B 690
THR B 739
CYH B 742
PHE B 804
 6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
6U7  B1001 (-3.8A)
 0.80A 4rzvB-5kkrB:
23.5		 4rzvB-5kkrB:
36.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 250
GLY A 253
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 1.17A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 250
PHE A 252
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 0.88A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 124
ALA A 137
LYS A 139
THR A 187
CYH A 190
GLY A 253
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 1.11A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 124
ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
GLY A 253
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
 0.96A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 124
ALA A 137
THR A 187
CYH A 190
SER A 193
PHE A 240
PHE A 252
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
 0.91A 4rzvB-5vcxA:
17.4		 4rzvB-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 226
ALA A 239
CYH A 292
PHE A 346
GLY A 379
GLY A 382
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
None
 1.17A 4rzvB-5vdkA:
22.1		 4rzvB-5vdkA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 226
ALA A 239
CYH A 292
SER A 296
PHE A 346
GLY A 379
 8X7  A 501 ( 4.5A)
8X7  A 501 ( 3.7A)
8X7  A 501 (-3.8A)
None
8X7  A 501 (-3.7A)
None
 0.91A 4rzvB-5vdkA:
22.1		 4rzvB-5vdkA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
SER A 102
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
None
 0.83A 4rzvB-5w5jA:
26.4		 4rzvB-5w5jA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 VAL A 899
ALA A 917
LEU A 947
THR A 963
PHE A1029
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
 0.58A 4rzvB-5wnoA:
27.6		 4rzvB-5wnoA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 VAL A  41
ALA A  54
CYH A 102
SER A 106
PHE A 165
GLY A 166
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-4.2A)
ANP  A 501 (-2.4A)
None
None
 0.78A 4rzvB-6ao5A:
24.1		 4rzvB-6ao5A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 VAL A 226
ALA A 237
LYS A 239
SER A 295
GLY A 357
GLY A 360
 None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
DL1  A 601 ( 4.6A)
DL1  A 601 ( 4.8A)
None
 1.10A 4rzvB-6bfnA:
24.6		 4rzvB-6bfnA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 VAL A 889
ALA A 906
LYS A 908
SER A 963
GLY A1020
GLY A1023
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-3.3A)
None
MG  A1203 ( 4.7A)
 1.39A 4rzvB-6c7yA:
13.5		 4rzvB-6c7yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 PHE A  83
SER A 647
HIS A 668
ASP A 185
 None
 1.41A 4rzvB-1b0kA:
0.0		 4rzvB-1b0kA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bmt METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		4 ILE A 832
SER A 838
HIS A 841
ASP A 757
 None
None
None
COB  A 122 (-4.1A)
 1.20A 4rzvB-1bmtA:
undetectable		 4rzvB-1bmtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 ILE A 155
SER A  80
HIS A 132
ASP A 264
 G6P  A 901 (-4.8A)
None
G6P  A 901 (-4.5A)
None
 1.37A 4rzvB-1gz5A:
0.0		 4rzvB-1gz5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		4 ILE A 128
PHE A  31
SER A 185
ASP A 214
 None
None
None
ZN  A1457 (-1.9A)
 1.39A 4rzvB-1ibqA:
undetectable		 4rzvB-1ibqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		4 ILE A 832
SER A 838
HIS A 841
ASP A 757
 None
 1.16A 4rzvB-1k7yA:
0.0		 4rzvB-1k7yA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q47 SEMAPHORIN 3A

(Mus musculus) 		PF01403
(Sema) 		4 ILE A 154
PHE A  80
HIS A 149
ASP A  63
 None
 1.25A 4rzvB-1q47A:
undetectable		 4rzvB-1q47A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3
ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF00022
(Actin)
PF04045
(P34-Arc) 		4 ILE A  97
PHE D 181
HIS A 108
ASP D 249
 None
 1.39A 4rzvB-1u2vA:
undetectable		 4rzvB-1u2vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF03070
(TENA_THI-4) 		4 ILE A   5
SER A 188
HIS A 187
ASP A  12
 None
 1.34A 4rzvB-1uddA:
0.6		 4rzvB-1uddA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965) 		4 ILE A 597
PHE A 673
SER A 548
ASP A 683
 None
None
None
CA  A 802 (-3.2A)
 1.40A 4rzvB-1w7cA:
0.4		 4rzvB-1w7cA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ILE A  39
PHE A 396
SER A 365
ASP A 387
 None
 1.10A 4rzvB-1w9xA:
undetectable		 4rzvB-1w9xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 ILE A 414
PHE A 497
SER A 403
ASP A 408
 None
 1.23A 4rzvB-1wd3A:
undetectable		 4rzvB-1wd3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 ILE A 638
PHE A  66
SER A 609
HIS A 617
 None
 1.30A 4rzvB-1wz2A:
undetectable		 4rzvB-1wz2A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 742
SER A 740
HIS A 824
ASP A 629
 None
 1.31A 4rzvB-1xfdA:
undetectable		 4rzvB-1xfdA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		4 ILE A 324
PHE A 233
HIS A 344
ASP A 220
 None
None
None
MG  A 400 (-2.7A)
 1.24A 4rzvB-1xfiA:
undetectable		 4rzvB-1xfiA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 ILE A 230
PHE A 145
SER A 295
ASP A  40
 None
 1.37A 4rzvB-1xvxA:
undetectable		 4rzvB-1xvxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 ILE A 253
SER A 250
HIS A 175
ASP A 265
 None
 1.42A 4rzvB-1yyrA:
undetectable		 4rzvB-1yyrA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		4 ILE A 178
PHE A   7
HIS A 375
ASP A 147
 None
 1.40A 4rzvB-2cunA:
undetectable		 4rzvB-2cunA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eez ALANINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 ILE A 171
PHE A 146
SER A 226
ASP A 264
 None
 1.44A 4rzvB-2eezA:
undetectable		 4rzvB-2eezA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9i F420-0:GAMMA-GLUTAMY
L LIGASE

(Archaeoglobus
fulgidus) 		PF01996
(F420_ligase) 		4 ILE A 148
PHE A 201
SER A 168
ASP A 196
 None
 1.29A 4rzvB-2g9iA:
undetectable		 4rzvB-2g9iA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A  36
PHE A  58
SER A 337
HIS A 368
 None
 1.32A 4rzvB-2gqdA:
undetectable		 4rzvB-2gqdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 117
PHE A 384
SER A 126
ASP A 237
 None
 1.29A 4rzvB-2hi4A:
undetectable		 4rzvB-2hi4A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmc DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 ILE A 104
PHE A 280
HIS A 120
ASP A  57
 MG  A 502 (-4.8A)
None
MG  A 502 (-4.6A)
None
 1.27A 4rzvB-2hmcA:
undetectable		 4rzvB-2hmcA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i54 PHOSPHOMANNOMUTASE

(Leishmania
mexicana) 		PF03332
(PMM) 		4 ILE A 157
PHE A 118
SER A 172
ASP A 147
 None
 1.42A 4rzvB-2i54A:
undetectable		 4rzvB-2i54A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		4 ILE B 333
SER A 269
HIS A 266
ASP A 246
 None
 1.20A 4rzvB-2ivfB:
undetectable		 4rzvB-2ivfB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj7 HEMOLYSIN II
REGULATORY PROTEIN

(Bacillus cereus) 		PF00440
(TetR_N) 		4 ILE A 108
PHE A  20
SER A 156
HIS A 152
 None
 1.33A 4rzvB-2jj7A:
undetectable		 4rzvB-2jj7A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kav SODIUM CHANNEL
PROTEIN TYPE 2
SUBUNIT ALPHA

(Homo sapiens) 		PF16905
(GPHH) 		4 ILE A1831
PHE A1795
SER A1819
ASP A1826
 None
 1.37A 4rzvB-2kavA:
undetectable		 4rzvB-2kavA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  51
SER A  30
HIS A   7
ASP A 122
 None
 1.16A 4rzvB-2lgzA:
undetectable		 4rzvB-2lgzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 128
SER A  30
HIS A   7
ASP A 122
 None
 1.33A 4rzvB-2lgzA:
undetectable		 4rzvB-2lgzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 ILE A  76
PHE A 256
HIS A  81
ASP A 135
 A3P  A 999 (-3.9A)
None
None
None
 1.43A 4rzvB-2oq2A:
undetectable		 4rzvB-2oq2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9q 2'-DEOXYCYTIDINE
5'-TRIPHOSPHATE
DEAMINASE

(Agrobacterium
fabrum) 		PF06559
(DCD) 		4 ILE A 149
PHE A 242
SER A 165
ASP A 121
 None
 1.21A 4rzvB-2r9qA:
0.2		 4rzvB-2r9qA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9z GLUTATHIONE AMIDE
REDUCTASE

(Marichromatium
gracile) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 134
PHE A  26
SER A 130
HIS A 120
 None
None
None
NI  A 466 (-3.4A)
 1.37A 4rzvB-2r9zA:
undetectable		 4rzvB-2r9zA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		4 ILE A 180
PHE A 172
HIS A 403
ASP A 134
 None
 1.31A 4rzvB-2xa2A:
undetectable		 4rzvB-2xa2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 PHE A 322
SER A 355
HIS A 353
ASP A 415
 None
3ES  A1636 (-4.3A)
3ES  A1635 (-3.8A)
3ES  A1635 ( 3.9A)
 1.23A 4rzvB-2xy9A:
undetectable		 4rzvB-2xy9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 PHE A 300
SER A 333
HIS A 331
ASP A 393
 None
3ES  A1611 (-4.4A)
3ES  A1611 (-3.8A)
3ES  A1611 (-3.4A)
 1.26A 4rzvB-2xydA:
undetectable		 4rzvB-2xydA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 485
SER A 503
HIS A 553
ASP A 436
 None
 1.31A 4rzvB-3ahiA:
undetectable		 4rzvB-3ahiA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 PHE A 485
SER A 503
HIS A 553
ASP A 436
 None
 1.26A 4rzvB-3ai7A:
undetectable		 4rzvB-3ai7A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayn RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		4 ILE A 314
PHE A  72
SER A 316
ASP A  80
 None
 1.37A 4rzvB-3aynA:
2.1		 4rzvB-3aynA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp8 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Chlorobaculum
tepidum) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 ILE A   5
PHE A 153
SER A 132
ASP A 118
 None
FAD  A 622 (-4.0A)
None
None
 1.42A 4rzvB-3cp8A:
undetectable		 4rzvB-3cp8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cql ENDOCHITINASE

(Carica papaya) 		PF00182
(Glyco_hydro_19) 		4 ILE A   6
PHE A  28
SER A   9
ASP A  32
 None
None
None
GOL  A 248 (-3.4A)
 1.42A 4rzvB-3cqlA:
undetectable		 4rzvB-3cqlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		4 ILE A 790
PHE A 754
SER A 763
ASP A 747
 None
None
SAH  A 854 ( 2.7A)
SAH  A 854 (-3.6A)
 1.26A 4rzvB-3gdhA:
undetectable		 4rzvB-3gdhA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 ILE P 292
PHE P 186
SER P 294
ASP P 280
 None
 1.35A 4rzvB-3hbuP:
undetectable		 4rzvB-3hbuP:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE

(Epichloe
festucae) 		PF00501
(AMP-binding) 		4 ILE A 415
SER A 413
HIS A 346
ASP A 340
 None
 1.39A 4rzvB-3iteA:
1.4		 4rzvB-3iteA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES21
40S RIBOSOMAL
PROTEIN US5

(Plasmodium
falciparum) 		PF00333
(Ribosomal_S5)
PF01249
(Ribosomal_S21e)
PF03719
(Ribosomal_S5_C) 		4 ILE G  69
PHE G 258
SER G  66
HIS Z  29
 None
 1.09A 4rzvB-3j7aG:
undetectable		 4rzvB-3j7aG:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 ILE A1963
PHE A1941
SER A1958
ASP A1945
 None
 1.04A 4rzvB-3jb9A:
undetectable		 4rzvB-3jb9A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		4 ILE A 408
PHE A  64
HIS A  80
ASP A  69
 None
 1.41A 4rzvB-3k9dA:
undetectable		 4rzvB-3k9dA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmv ALPHA-L-ARABINOFURAN
OSIDASE B

(Ruminiclostridium
thermocellum) 		PF05270
(AbfB) 		4 ILE A 118
PHE A  28
SER A 110
ASP A  76
 None
FMT  A 162 (-3.8A)
None
CA  A 163 (-3.2A)
 1.42A 4rzvB-3kmvA:
undetectable		 4rzvB-3kmvA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktb ARSENICAL RESISTANCE
OPERON TRANS-ACTING
REPRESSOR

(Bacteroides
vulgatus) 		PF06953
(ArsD) 		4 ILE A  41
PHE A   7
SER A  95
ASP A  79
 None
 1.19A 4rzvB-3ktbA:
undetectable		 4rzvB-3ktbA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 ILE A 103
PHE A 293
SER A 304
ASP A  97
 None
 1.44A 4rzvB-3kv4A:
undetectable		 4rzvB-3kv4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kya PUTATIVE PHOSPHATASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 ILE A 351
PHE A 285
SER A 469
ASP A 234
 CL  A  21 (-4.4A)
None
None
EDO  A   1 (-2.8A)
 1.33A 4rzvB-3kyaA:
undetectable		 4rzvB-3kyaA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		4 ILE B  17
PHE B  64
SER B  20
ASP B 158
 None
SAM  B 301 (-3.7A)
None
None
 1.38A 4rzvB-3lcvB:
0.4		 4rzvB-3lcvB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		4 PHE A 149
SER A 132
HIS A 101
ASP A 154
 None
None
None
CA  A 323 ( 2.5A)
 1.32A 4rzvB-3m1rA:
undetectable		 4rzvB-3m1rA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 335
PHE A 108
SER A 114
ASP A  41
 None
None
SEP  A 338 ( 2.9A)
None
 1.38A 4rzvB-3mvjA:
20.8		 4rzvB-3mvjA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opn PUTATIVE HEMOLYSIN

(Lactococcus
lactis) 		PF01728
(FtsJ) 		4 ILE A  96
PHE A 118
SER A  98
ASP A  86
 None
 1.36A 4rzvB-3opnA:
0.9		 4rzvB-3opnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 ILE A  92
PHE A 100
SER A 114
ASP A 105
 None
 1.43A 4rzvB-3qivA:
undetectable		 4rzvB-3qivA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qml 78 KDA
GLUCOSE-REGULATED
PROTEIN HOMOLOG
NUCLEOTIDE EXCHANGE
FACTOR SIL1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70)
PF16782
(SIL1) 		4 ILE C 244
PHE C 155
SER C 239
ASP A 330
 None
 1.43A 4rzvB-3qmlC:
undetectable		 4rzvB-3qmlC:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 ILE A 298
PHE A  60
SER A 240
ASP A  39
 None
None
None
EPE  A 338 (-2.7A)
 1.43A 4rzvB-3qz4A:
undetectable		 4rzvB-3qz4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		4 ILE A 193
PHE A 395
SER A 123
ASP A 209
 None
 1.37A 4rzvB-3vlaA:
undetectable		 4rzvB-3vlaA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0d ELASTASE INHIBITOR
AFUEI

(Aspergillus
fumigatus) 		PF11720
(Inhibitor_I78) 		4 ILE A  54
SER A  64
HIS A  66
ASP A  41
 None
 1.27A 4rzvB-3w0dA:
undetectable		 4rzvB-3w0dA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cit VANADIUM-DEPENDENT
HALOPEROXIDASE

(Zobellia
galactanivorans) 		PF01569
(PAP2) 		4 PHE A 375
SER A 361
HIS A 360
ASP A 383
 None
None
VO4  A1451 ( 3.9A)
None
 1.27A 4rzvB-4citA:
undetectable		 4rzvB-4citA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 ILE A1275
SER A1278
HIS A1252
ASP A1069
 None
None
MN  A1502 (-3.7A)
None
 1.15A 4rzvB-4fbqA:
undetectable		 4rzvB-4fbqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 4 ILE B 275
SER B 278
HIS B 252
ASP B  69
 None
None
MN  B 501 (-3.5A)
None
 1.22A 4rzvB-4fcxB:
undetectable		 4rzvB-4fcxB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		4 ILE A 136
PHE A  79
SER A 145
ASP A 169
 None
 1.17A 4rzvB-4h59A:
undetectable		 4rzvB-4h59A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
HYPOXIA INDUCIBLE
FACTOR 1-ALPHA

(Homo sapiens) 		PF08447
(PAS_3)
PF14598
(PAS_11) 		4 ILE A 324
PHE A 242
SER B 443
ASP B 377
 None
 0.97A 4rzvB-4h6jA:
undetectable		 4rzvB-4h6jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 115
PHE A 384
SER A 124
ASP A 235
 BHF  A 602 (-4.7A)
None
None
None
 1.26A 4rzvB-4i8vA:
undetectable		 4rzvB-4i8vA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 340
PHE A 177
SER A 263
ASP A 169
 None
 1.41A 4rzvB-4jr7A:
20.4		 4rzvB-4jr7A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		4 ILE A 203
PHE A 265
SER A 199
ASP A 145
 None
 1.06A 4rzvB-4k05A:
undetectable		 4rzvB-4k05A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 4 ILE A 320
SER A 302
HIS A 244
ASP A 297
 None
 1.28A 4rzvB-4lgnA:
undetectable		 4rzvB-4lgnA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5b COBALAMIN
BIOSYNTHESIS PROTEIN
CBIM

(Caldanaerobacter
subterraneus) 		PF01891
(CbiM) 		4 ILE A  69
PHE A  92
HIS A 190
ASP A 100
 None
 1.19A 4rzvB-4m5bA:
undetectable		 4rzvB-4m5bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mst CLASS I CHITINASE

(Hevea
brasiliensis) 		PF00182
(Glyco_hydro_19) 		4 ILE A  56
PHE A  78
SER A  59
ASP A  82
 None
 1.29A 4rzvB-4mstA:
undetectable		 4rzvB-4mstA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		4 ILE A 203
PHE A 220
SER A 206
ASP A 236
 None
 1.01A 4rzvB-4nj5A:
undetectable		 4rzvB-4nj5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 306
PHE A 250
HIS A 211
ASP A 231
 None
 1.39A 4rzvB-4uhiA:
undetectable		 4rzvB-4uhiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		4 ILE A 571
PHE A 596
HIS A 686
ASP A 644
 None
 1.40A 4rzvB-4wiwA:
undetectable		 4rzvB-4wiwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww3 RHODOPSIN

(Todarodes
pacificus) 		PF00001
(7tm_1) 		4 ILE A 314
PHE A  72
SER A 316
ASP A  80
 None
None
PLM  A 403 (-3.1A)
None
 1.37A 4rzvB-4ww3A:
2.0		 4rzvB-4ww3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yke MRE11

(Chaetomium
thermophilum) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 ILE A 266
SER A 269
HIS A 243
ASP A  61
 None
None
MN  A 601 (-3.5A)
None
 1.25A 4rzvB-4ykeA:
undetectable		 4rzvB-4ykeA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 ILE A   5
PHE A  25
SER A 106
ASP A 113
 None
None
SO4  A 806 (-2.6A)
None
 0.97A 4rzvB-4zlgA:
undetectable		 4rzvB-4zlgA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 PHE A 306
SER A 339
HIS A 337
ASP A 399
 None
None
MLT  A1615 (-3.8A)
None
 1.13A 4rzvB-5a2rA:
undetectable		 4rzvB-5a2rA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeu BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Paraburkholderia
xenovorans) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 135
PHE B 187
SER B 115
ASP B  39
 None
 1.18A 4rzvB-5aeuB:
undetectable		 4rzvB-5aeuB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 ILE A 517
PHE A  22
SER A 502
ASP A  25
 None
 1.41A 4rzvB-5ah5A:
undetectable		 4rzvB-5ah5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czj DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 ILE A 124
PHE A 300
HIS A 140
ASP A  77
 None
 1.38A 4rzvB-5czjA:
undetectable		 4rzvB-5czjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxf TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 ILE A 299
PHE A 160
SER A  66
ASP A 435
 None
 1.31A 4rzvB-5dxfA:
undetectable		 4rzvB-5dxfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		4 ILE A  60
SER A  71
HIS A  96
ASP A 122
 None
SAH  A 400 ( 4.8A)
None
None
 1.23A 4rzvB-5f2oA:
undetectable		 4rzvB-5f2oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftz CHITIN BINDING
PROTEIN

(Streptomyces
lividans) 		PF03067
(LPMO_10) 		4 ILE A  77
PHE A 112
SER A  79
ASP A 198
 None
 1.44A 4rzvB-5ftzA:
undetectable		 4rzvB-5ftzA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A 202
PHE A 272
SER A 445
HIS A 447
 None
 1.25A 4rzvB-5h80A:
0.8		 4rzvB-5h80A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 ILE A 164
SER A  89
HIS A 141
ASP A 274
 None
 1.35A 4rzvB-5hxaA:
undetectable		 4rzvB-5hxaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2

(Homo sapiens) 		PF05609
(LAP1C) 		4 ILE B 328
PHE B 280
SER B 326
ASP B 391
 None
 1.41A 4rzvB-5j1sB:
undetectable		 4rzvB-5j1sB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 ILE A  86
PHE A 310
SER A 218
HIS A  90
 None
 1.09A 4rzvB-5jodA:
undetectable		 4rzvB-5jodA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lg4 PROTEIN SSO2

(Saccharomyces
cerevisiae) 		PF00804
(Syntaxin) 		4 ILE A  57
PHE A 218
SER A  89
ASP A 137
 None
 0.93A 4rzvB-5lg4A:
undetectable		 4rzvB-5lg4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 ILE A  38
PHE A  11
HIS A  58
ASP A 777
 None
 1.38A 4rzvB-5m2nA:
undetectable		 4rzvB-5m2nA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE A 685
PHE A 490
HIS A 682
ASP A 515
 None
 1.15A 4rzvB-5nd5A:
undetectable		 4rzvB-5nd5A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		4 ILE A 157
SER A  82
HIS A 134
ASP A 267
 None
 1.35A 4rzvB-5tvgA:
undetectable		 4rzvB-5tvgA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqd DUMPY: SHORTER THAN
WILD-TYPE

(Caenorhabditis
elegans) 		no annotation 4 ILE A1408
PHE A1586
SER A1403
ASP A1454
 PG0  A1703 (-4.2A)
None
None
FE2  A1702 (-2.6A)
 1.32A 4rzvB-5uqdA:
undetectable		 4rzvB-5uqdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 ILE A 165
SER A  90
HIS A 142
ASP A 279
 G6P  A 502 (-4.8A)
None
G6P  A 502 (-4.7A)
None
 1.27A 4rzvB-5v0tA:
undetectable		 4rzvB-5v0tA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viq MONOMERIC
NEAR-INFRARED
FLUORESCENT PROTEIN
MIRFP709

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 ILE A  79
PHE A  57
SER A  41
HIS A  45
 None
 1.40A 4rzvB-5viqA:
undetectable		 4rzvB-5viqA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 4 ILE A 164
SER A 147
HIS A 321
ASP A  20
 None
 1.23A 4rzvB-5wa3A:
undetectable		 4rzvB-5wa3A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		4 ILE A 148
PHE A1093
HIS A1102
ASP A1097
 None
 1.36A 4rzvB-5xeiA:
undetectable		 4rzvB-5xeiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		4 PHE B 231
SER B 177
HIS B 178
ASP B 208
 None
 1.33A 4rzvB-5xeqB:
undetectable		 4rzvB-5xeqB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF10588
(NADH-G_4Fe-4S_3)
PF13459
(Fer4_15)
PF13510
(Fer2_4) 		4 PHE B 227
SER D 186
HIS D  88
ASP C 189
 None
 1.42A 4rzvB-5xfaB:
undetectable		 4rzvB-5xfaB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 4 ILE A 158
PHE A 121
SER A 131
HIS A 133
 None
 1.28A 4rzvB-5y30A:
undetectable		 4rzvB-5y30A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 ILE A 479
PHE A 502
SER A 410
ASP A 401
 None
NAG  A1016 (-4.5A)
None
None
 1.34A 4rzvB-6bv2A:
undetectable		 4rzvB-6bv2A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9w EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TRANSPORTER
PROTEIN LSM14
HOMOLOG A

(Homo sapiens) 		no annotation 4 ILE A  72
PHE A  62
SER A  34
ASP B 979
 None
 1.39A 4rzvB-6f9wA:
undetectable		 4rzvB-6f9wA:
17.72