SIMILAR PATTERNS OF AMINO ACIDS FOR 4RZV_A_032A801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmi PROTEIN INHIBITOR OF
NEURONAL NITRIC
OXIDE SYNTHASE

(Homo sapiens) 		PF01221
(Dynein_light) 		4 ILE A  38
VAL A  58
PHE A  73
CYH A  24
 None
 1.31A 4rzvA-1cmiA:
undetectable		 4rzvA-1cmiA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cte CATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1) 		4 ILE A 201
VAL A 217
CYH A 240
HIS A 199
 PYS  A 255 (-4.6A)
None
None
PYS  A 255 ( 4.1A)
 1.13A 4rzvA-1cteA:
0.0		 4rzvA-1cteA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 4 ILE B 708
VAL B 768
PHE B 757
HIS B 710
 None
 1.36A 4rzvA-1ej6B:
0.0		 4rzvA-1ej6B:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ILE A 261
VAL A 262
PHE A 187
HIS A  26
 None
 1.26A 4rzvA-1flgA:
0.1		 4rzvA-1flgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		4 VAL A 235
PHE A 193
CYH A 267
HIS A 292
 None
 1.17A 4rzvA-1fs2A:
undetectable		 4rzvA-1fs2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 ILE A  67
VAL A 116
PHE A 185
HIS A 143
 None
 1.27A 4rzvA-1lzkA:
0.0		 4rzvA-1lzkA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk1 SEX COMB ON MIDLEG
CG9495-PA

(Drosophila
melanogaster) 		PF00536
(SAM_1) 		4 ILE B  26
VAL B  22
CYH B  73
HIS B  36
 None
 1.35A 4rzvA-1pk1B:
undetectable		 4rzvA-1pk1B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 431
VAL A 349
PHE A 451
CYH A 309
 None
None
G24  A 462 (-4.7A)
None
 1.27A 4rzvA-1q4xA:
undetectable		 4rzvA-1q4xA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		4 ILE A  62
VAL A  33
PHE A  12
CYH A  69
 None
 1.38A 4rzvA-1q8kA:
undetectable		 4rzvA-1q8kA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj7 ECTODYSPLASIN A

(Homo sapiens) 		PF00229
(TNF) 		4 ILE A 369
VAL A 309
PHE A 379
HIS A 366
 None
 1.35A 4rzvA-1rj7A:
0.0		 4rzvA-1rj7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE A 709
VAL A 707
PHE A 732
CYH A 622
 None
 1.26A 4rzvA-1sb3A:
0.0		 4rzvA-1sb3A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmx HYDROXYQUINOL
1,2-DIOXYGENASE

(Pimelobacter
simplex) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ILE A 125
VAL A 155
PHE A 239
CYH A 134
 None
 1.03A 4rzvA-1tmxA:
undetectable		 4rzvA-1tmxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhd PUTATIVE
ACETYLTRANSFERASE/AC
YLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 ILE A  84
PHE A 113
CYH A  88
HIS A  64
 None
None
None
SO4  A 201 (-3.6A)
 1.36A 4rzvA-1xhdA:
undetectable		 4rzvA-1xhdA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		5 ILE A 102
VAL A 132
PHE A  80
CYH A  75
HIS A  39
 None
 1.48A 4rzvA-1xtzA:
undetectable		 4rzvA-1xtzA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 ILE A 508
VAL A 498
PHE A 371
HIS A 478
 None
 1.33A 4rzvA-1yvpA:
undetectable		 4rzvA-1yvpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 509
VAL A 512
PHE A 562
HIS A 542
 None
 1.35A 4rzvA-1z1wA:
undetectable		 4rzvA-1z1wA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 697
VAL A 647
PHE A 641
HIS A 743
 None
 1.20A 4rzvA-1z68A:
undetectable		 4rzvA-1z68A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		4 ILE A  88
VAL A  24
PHE A  44
HIS A  85
 None
 1.33A 4rzvA-1zoiA:
undetectable		 4rzvA-1zoiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME

(Homo sapiens) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A 368
VAL A 314
PHE A 363
CYH A 392
 None
 1.31A 4rzvA-1zxnA:
undetectable		 4rzvA-1zxnA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axc COLICIN E7

(Escherichia
coli) 		PF03515
(Cloacin) 		4 ILE A 267
VAL A 278
PHE A  87
HIS A 216
 None
 1.03A 4rzvA-2axcA:
undetectable		 4rzvA-2axcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 ILE A 177
VAL A 123
PHE A 147
HIS A 207
 None
None
None
SF4  A1000 (-4.1A)
 1.15A 4rzvA-2b3xA:
undetectable		 4rzvA-2b3xA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE

(Podophyllum
peltatum) 		PF13561
(adh_short_C2) 		4 ILE A  87
VAL A 139
PHE A 130
HIS A  90
 None
 1.35A 4rzvA-2bgkA:
undetectable		 4rzvA-2bgkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 110
VAL A 109
PHE A 121
HIS A  72
 None
None
None
FAD  A 600 (-2.4A)
 1.33A 4rzvA-2bvgA:
undetectable		 4rzvA-2bvgA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		4 ILE A 327
VAL A  13
CYH A  43
HIS A  52
 None
 1.19A 4rzvA-2cwfA:
undetectable		 4rzvA-2cwfA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE

(Staphylococcus
aureus) 		PF02152
(FolB) 		4 ILE A  64
VAL A  61
PHE A   6
HIS A  75
 None
 1.20A 4rzvA-2dhnA:
undetectable		 4rzvA-2dhnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 ILE A  47
VAL A  57
PHE A 113
HIS A  45
 None
 0.98A 4rzvA-2e3jA:
undetectable		 4rzvA-2e3jA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		4 ILE A 313
VAL A  25
PHE A  84
HIS A  41
 None
 1.22A 4rzvA-2f8qA:
undetectable		 4rzvA-2f8qA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gry KINESIN-LIKE PROTEIN
KIF2

(Homo sapiens) 		PF00225
(Kinesin) 		4 ILE A 274
VAL A 271
PHE A 265
CYH A 282
 None
 1.36A 4rzvA-2gryA:
undetectable		 4rzvA-2gryA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3b HUMAN CANCER-RELATED
NTPASE

(Homo sapiens) 		PF03266
(NTPase_1) 		4 ILE A 157
VAL A 154
PHE A 120
HIS A   3
 None
 1.24A 4rzvA-2i3bA:
undetectable		 4rzvA-2i3bA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		4 ILE A 319
VAL A  35
PHE A  94
HIS A  51
 None
 1.20A 4rzvA-2uwfA:
undetectable		 4rzvA-2uwfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whd THIOREDOXIN
REDUCTASE

(Hordeum vulgare) 		PF07992
(Pyr_redox_2) 		4 ILE A  15
VAL A  13
CYH A 310
HIS A  23
 None
 1.28A 4rzvA-2whdA:
undetectable		 4rzvA-2whdA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xbl PHOSPHOHEPTOSE
ISOMERASE

(Burkholderia
pseudomallei) 		PF13580
(SIS_2) 		4 ILE A 120
VAL A  50
PHE A 194
HIS A 178
 None
 1.28A 4rzvA-2xblA:
undetectable		 4rzvA-2xblA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xci 3-DEOXY-D-MANNO-2-OC
TULOSONIC ACID
TRANSFERASE

(Aquifex
aeolicus) 		PF04413
(Glycos_transf_N) 		4 ILE A  95
VAL A 116
PHE A 163
HIS A  46
 None
 1.28A 4rzvA-2xciA:
undetectable		 4rzvA-2xciA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 180
VAL A 178
PHE A 164
HIS A 142
 None
 1.32A 4rzvA-2yxxA:
undetectable		 4rzvA-2yxxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ILE A 414
VAL A 415
PHE A 368
HIS A 303
 None
 1.25A 4rzvA-2zr2A:
1.7		 4rzvA-2zr2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ILE A  22
VAL A 119
PHE A 135
CYH A  40
 None
 1.22A 4rzvA-3eh7A:
undetectable		 4rzvA-3eh7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A 193
VAL A 223
PHE A 336
CYH A 346
 None
 1.14A 4rzvA-3gdeA:
undetectable		 4rzvA-3gdeA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ILE A 374
VAL A 297
PHE A 201
HIS A 462
 None
 1.23A 4rzvA-3h8fA:
undetectable		 4rzvA-3h8fA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9

(Thermus
thermophilus) 		PF12838
(Fer4_7) 		4 ILE 9  68
VAL 9  70
CYH 9 108
HIS 9  41
 SF4  9 183 (-4.8A)
None
SF4  9 184 (-2.3A)
SF4  9 183 (-4.5A)
 1.09A 4rzvA-3i9v9:
undetectable		 4rzvA-3i9v9:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 ILE B  72
VAL B  71
CYH B   8
HIS B  15
 None
 1.35A 4rzvA-3iqdB:
0.9		 4rzvA-3iqdB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis) 		PF00303
(Thymidylat_synt) 		4 ILE A 170
VAL A 174
PHE A  42
HIS A  10
 None
 1.33A 4rzvA-3ix6A:
undetectable		 4rzvA-3ix6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvo GP6

(Escherichia
virus HK97) 		PF05135
(Phage_connect_1) 		4 ILE A  55
VAL A   8
CYH A  40
HIS A  95
 None
 1.30A 4rzvA-3jvoA:
undetectable		 4rzvA-3jvoA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF01242
(PTPS) 		4 ILE A  80
VAL A 131
CYH A  12
HIS A  38
 None
None
None
ZN  A 200 (-3.3A)
 1.31A 4rzvA-3jygA:
undetectable		 4rzvA-3jygA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		4 VAL A 339
PHE A 394
CYH A 355
HIS A 360
 None
 1.30A 4rzvA-3jz4A:
undetectable		 4rzvA-3jz4A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ILE A 113
VAL A  37
PHE A  60
HIS A 282
 None
 1.14A 4rzvA-3lpdA:
undetectable		 4rzvA-3lpdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 ILE A 175
VAL A 174
PHE A 143
CYH A 246
 None
 1.33A 4rzvA-3oh8A:
undetectable		 4rzvA-3oh8A:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
VAL A 363
PHE A 408
CYH A 424
 SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
None
SM5  A   1 ( 4.4A)
 0.46A 4rzvA-3omvA:
12.9		 4rzvA-3omvA:
70.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmq DECAHEME CYTOCHROME
C MTRF

(Shewanella
oneidensis) 		no annotation 4 ILE A 468
VAL A 467
CYH A 546
HIS A 527
 HEC  A 675 ( 4.2A)
HEC  A 677 (-4.4A)
HEC  A 677 (-1.8A)
HEC  A 675 ( 3.0A)
 0.90A 4rzvA-3pmqA:
undetectable		 4rzvA-3pmqA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 ILE A 559
VAL A 649
PHE A 564
HIS A 549
 None
 1.35A 4rzvA-3poyA:
undetectable		 4rzvA-3poyA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A  12
VAL A   7
PHE A 101
HIS A  14
 None
 1.09A 4rzvA-3pwzA:
undetectable		 4rzvA-3pwzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		4 ILE B 494
PHE B 501
CYH B 412
HIS B  66
 None
 1.22A 4rzvA-3q75B:
undetectable		 4rzvA-3q75B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4i CITRATE LYASE

(Paraburkholderia
xenovorans) 		PF03328
(HpcH_HpaI) 		4 ILE A 261
VAL A 262
PHE A  80
HIS A 222
 None
 1.07A 4rzvA-3r4iA:
undetectable		 4rzvA-3r4iA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjs DYNEIN LIGHT CHAIN
MOTOR PROTEIN

(Toxoplasma
gondii) 		PF01221
(Dynein_light) 		4 ILE A  38
VAL A  58
PHE A  73
CYH A  24
 None
 1.13A 4rzvA-3rjsA:
undetectable		 4rzvA-3rjsA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 ILE L 372
VAL L 375
PHE L 346
HIS L 446
 None
 1.38A 4rzvA-3rkoL:
1.6		 4rzvA-3rkoL:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 4 ILE A 271
VAL A 200
PHE A 110
HIS A 189
 None
 1.16A 4rzvA-3ssmA:
undetectable		 4rzvA-3ssmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ILE A 632
VAL A 702
PHE A 694
HIS A 665
 None
 1.35A 4rzvA-3thzA:
undetectable		 4rzvA-3thzA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ILE A 113
VAL A  37
PHE A  60
HIS A 282
 None
 1.20A 4rzvA-3ti7A:
undetectable		 4rzvA-3ti7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		4 ILE A 430
VAL A 433
PHE A 439
CYH A 386
 HEC  A 904 ( 3.9A)
HEC  A 904 ( 3.9A)
HEC  A 905 (-4.5A)
HEC  A 904 (-1.8A)
 1.23A 4rzvA-3ufkA:
undetectable		 4rzvA-3ufkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		4 ILE A 648
VAL A 647
CYH A 751
HIS A 728
 HEC  A 906 ( 3.8A)
HEC  A 909 (-4.6A)
HEC  A 909 (-1.9A)
HEC  A 906 ( 3.1A)
 1.01A 4rzvA-3ufkA:
undetectable		 4rzvA-3ufkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		4 ILE A  32
VAL A   3
CYH A  18
HIS A  24
 None
 1.33A 4rzvA-3w4kA:
undetectable		 4rzvA-3w4kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 4 ILE B 444
VAL B 442
PHE B 574
HIS B 450
 None
 1.32A 4rzvA-3x17B:
undetectable		 4rzvA-3x17B:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		4 ILE A 134
VAL A 102
PHE A  82
CYH A 129
 None
 1.12A 4rzvA-4dppA:
undetectable		 4rzvA-4dppA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 ILE A 357
VAL A 305
PHE A 352
CYH A 381
 None
 1.21A 4rzvA-4gfhA:
undetectable		 4rzvA-4gfhA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2d NADPH-DEPENDENT
DIFLAVIN
OXIDOREDUCTASE 1

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		4 ILE A  55
VAL A  54
PHE A  76
CYH A  58
 None
 1.36A 4rzvA-4h2dA:
undetectable		 4rzvA-4h2dA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilk STARVATION SENSING
PROTEIN RSPB

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  43
VAL A 111
CYH A  37
HIS A  47
 None
None
MN  A 402 (-3.2A)
None
 1.15A 4rzvA-4ilkA:
undetectable		 4rzvA-4ilkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 ILE A 251
VAL A 105
PHE A 187
HIS A 249
 None
 1.20A 4rzvA-4j5uA:
undetectable		 4rzvA-4j5uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mob ACYL-COENZYME A
THIOESTERASE 12

(Homo sapiens) 		PF03061
(4HBT) 		4 ILE A  71
VAL A  91
PHE A 108
HIS A  19
 None
 1.25A 4rzvA-4mobA:
undetectable		 4rzvA-4mobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 ILE A 219
VAL A 269
PHE A  76
HIS A 214
 None
 1.32A 4rzvA-4n0rA:
undetectable		 4rzvA-4n0rA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbw SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Plesiocystis
pacifica) 		PF13561
(adh_short_C2) 		4 ILE A  83
VAL A  80
PHE A 134
HIS A  38
 None
 1.35A 4rzvA-4nbwA:
undetectable		 4rzvA-4nbwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		4 ILE A 207
VAL A 210
PHE A 217
CYH A 223
 None
 1.34A 4rzvA-4nj5A:
undetectable		 4rzvA-4nj5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oue PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 ILE A 206
VAL A 207
PHE A 217
HIS A 170
 None
 1.38A 4rzvA-4oueA:
undetectable		 4rzvA-4oueA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		4 ILE A 318
VAL A  34
PHE A  94
HIS A  51
 None
 1.24A 4rzvA-4pueA:
undetectable		 4rzvA-4pueA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 ILE A  23
VAL A  89
PHE A 166
CYH A 185
 None
 1.23A 4rzvA-4weoA:
undetectable		 4rzvA-4weoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 131
VAL A 110
CYH A  72
HIS A  82
 None
 1.38A 4rzvA-4wojA:
undetectable		 4rzvA-4wojA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28

(Cytomegalovirus) 		PF00001
(7tm_1) 		4 ILE A 204
VAL A 203
CYH A 120
HIS A 283
 None
UNL  A 409 ( 4.2A)
SIN  A 416 ( 4.0A)
None
 1.33A 4rzvA-4xt1A:
undetectable		 4rzvA-4xt1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqd ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00989
(PAS)
PF08447
(PAS_3) 		4 ILE B 223
VAL B 101
PHE B 134
CYH B 195
 None
 1.27A 4rzvA-4zqdB:
undetectable		 4rzvA-4zqdB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ILE A 485
VAL A 482
PHE A  20
HIS A 645
 None
 1.33A 4rzvA-5a31A:
undetectable		 4rzvA-5a31A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		4 ILE A 129
PHE A 423
CYH A 207
HIS A 127
 None
 1.14A 4rzvA-5d2eA:
undetectable		 4rzvA-5d2eA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		4 ILE A  87
VAL A 115
CYH A  80
HIS A  89
 None
 1.01A 4rzvA-5dpdA:
2.2		 4rzvA-5dpdA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		4 ILE A  87
VAL A 115
CYH A  80
HIS A 478
 None
 1.32A 4rzvA-5dpdA:
2.2		 4rzvA-5dpdA:
18.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 463
VAL A 471
PHE A 516
CYH A 532
 5XJ  A 801 ( 4.7A)
5XJ  A 801 (-4.6A)
None
5XJ  A 801 (-4.6A)
 0.54A 4rzvA-5fd2A:
14.0		 4rzvA-5fd2A:
93.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 471
PHE A 516
CYH A 532
HIS A 539
 5XJ  A 801 (-4.6A)
None
5XJ  A 801 (-4.6A)
None
 0.98A 4rzvA-5fd2A:
14.0		 4rzvA-5fd2A:
93.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		4 ILE A 237
VAL A 161
PHE A 212
HIS A 235
 None
 1.39A 4rzvA-5gtkA:
undetectable		 4rzvA-5gtkA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 ILE A 158
VAL A 159
PHE A 138
HIS A 466
 None
 1.28A 4rzvA-5hmpA:
undetectable		 4rzvA-5hmpA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		4 ILE A 181
VAL A 186
PHE A 213
CYH A 158
 None
 1.32A 4rzvA-5hstA:
undetectable		 4rzvA-5hstA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		4 ILE A  93
VAL A  92
PHE A 334
CYH A 369
 None
 1.07A 4rzvA-5i6zA:
0.2		 4rzvA-5i6zA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 ILE A  17
VAL A  90
PHE A 160
CYH A 181
 NAD  A 302 (-3.8A)
None
None
None
 1.25A 4rzvA-5ilgA:
undetectable		 4rzvA-5ilgA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		4 ILE A 189
VAL A 159
PHE A 124
CYH A 243
 None
 0.98A 4rzvA-5iw7A:
undetectable		 4rzvA-5iw7A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 419
VAL A 446
PHE A 397
HIS A 432
 None
 0.88A 4rzvA-5iy9A:
1.2		 4rzvA-5iy9A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ILE A 271
VAL A 656
PHE A 227
HIS A 646
 None
 1.06A 4rzvA-5jxkA:
2.1		 4rzvA-5jxkA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA

(Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ILE B 315
VAL B 314
PHE B 375
CYH B 398
 None
 1.34A 4rzvA-5n1qB:
undetectable		 4rzvA-5n1qB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ILE B 316
VAL B 315
PHE B 376
CYH B 399
 None
 1.36A 4rzvA-5n28B:
undetectable		 4rzvA-5n28B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 4 ILE A 454
VAL A 450
PHE A 415
CYH A 410
 None
 1.35A 4rzvA-5t3bA:
undetectable		 4rzvA-5t3bA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN

(Human
betaherpesvirus
5;
Lama glama) 		no annotation 4 ILE A 204
VAL A 203
CYH A 120
HIS A 283
 None
 1.33A 4rzvA-5wb1A:
0.7		 4rzvA-5wb1A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 4 ILE B2669
VAL B2668
CYH B 570
HIS B 567
 None
None
ZN  B8008 (-2.2A)
None
 1.37A 4rzvA-5wfcB:
undetectable		 4rzvA-5wfcB:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wof DYNEIN LIGHT CHAIN
1, PUTATIVE

(Plasmodium
falciparum) 		PF01221
(Dynein_light) 		4 ILE A  32
VAL A  52
PHE A  67
CYH A  18
 None
 1.32A 4rzvA-5wofA:
undetectable		 4rzvA-5wofA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1

(Yarrowia
lipolytica) 		no annotation 4 ILE A 233
VAL A 231
PHE A 215
HIS A 192
 None
 1.23A 4rzvA-5y9dA:
undetectable		 4rzvA-5y9dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE

(Moraxella sp.
HMSC061H09) 		no annotation 4 ILE A 421
VAL A 268
PHE A 573
HIS A 414
 None
 1.35A 4rzvA-6bnfA:
undetectable		 4rzvA-6bnfA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 ILE A 157
VAL A 137
PHE A 241
CYH A 128
 None
None
None
GOL  A 503 (-3.0A)
 1.38A 4rzvA-6enoA:
undetectable		 4rzvA-6enoA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 4 ILE A 321
VAL A  34
PHE A  94
HIS A  51
 None
 1.16A 4rzvA-6fhfA:
undetectable		 4rzvA-6fhfA:
undetectable