SIMILAR PATTERNS OF AMINO ACIDS FOR 4RZV_A_032A801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 428
LYS A 430
ILE A 472
THR A 474
PHE A 540
GLY A 541
 None
 0.63A 4rzvA-1k2pA:
8.1		 4rzvA-1k2pA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
ILE A 264
THR A 266
SER A 273
PHE A 333
 None
 0.81A 4rzvA-1k9aA:
7.7		 4rzvA-1k9aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkr AZURIN-I

(Achromobacter
xylosoxidans) 		PF00127
(Copper-bind) 		5 ILE A  87
THR A  84
SER A   4
PHE A  15
GLY A   9
 None
 0.90A 4rzvA-1rkrA:
undetectable		 4rzvA-1rkrA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS B 296
ILE B 364
PHE B 421
GLY B 431
PHE B 433
 None
 0.94A 4rzvA-2a1aB:
21.9		 4rzvA-2a1aB:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA X  37
LYS X  39
ILE X  80
THR X  82
SER X  89
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.1A)
STU  X 902 ( 4.0A)
 0.68A 4rzvA-2dq7X:
27.2		 4rzvA-2dq7X:
33.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ft7 AZURIN

(Pseudomonas
aeruginosa) 		PF00127
(Copper-bind) 		5 ILE A  87
THR A  84
SER A   4
PHE A  15
GLY A   9
 None
 0.87A 4rzvA-2ft7A:
undetectable		 4rzvA-2ft7A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
ILE A 336
THR A 338
SER A 345
PHE A 405
 H8H  A 534 (-3.2A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
None
 0.72A 4rzvA-2h8hA:
7.6		 4rzvA-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
LYS A 295
ILE A 336
THR A 338
SER A 345
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
 0.85A 4rzvA-2h8hA:
7.6		 4rzvA-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ILE A 336
THR A 338
SER A 345
PHE A 405
GLY A 406
 H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 ( 4.5A)
None
None
 0.94A 4rzvA-2h8hA:
7.6		 4rzvA-2h8hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
ILE A 336
THR A 338
SER A 345
PHE A 405
 QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.7A)
None
 0.75A 4rzvA-2hckA:
11.3		 4rzvA-2hckA:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 271
LYS A 273
ILE A 314
THR A 316
SER A 323
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
 0.57A 4rzvA-2hk5A:
26.3		 4rzvA-2hk5A:
32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 271
LYS A 273
THR A 316
SER A 323
PHE A 383
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
None
 0.93A 4rzvA-2hk5A:
26.3		 4rzvA-2hk5A:
32.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
LYS A  49
ILE A 106
PHE A 159
GLY A 170
 None
 0.48A 4rzvA-2i6lA:
7.3		 4rzvA-2i6lA:
27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 271
LYS A 273
ILE A 314
THR A 316
SER A 323
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
None
 0.53A 4rzvA-2og8A:
8.0		 4rzvA-2og8A:
33.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ALA X  53
LYS X  55
LEU X 101
ILE X 115
SER X 124
PHE X 191
 HMD  X 400 (-3.5A)
HMD  X 400 (-4.2A)
HMD  X 400 (-4.2A)
None
None
None
 0.95A 4rzvA-2pmoX:
22.5		 4rzvA-2pmoX:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LYS A 217
LEU A 245
THR A 265
SER A 272
PHE A 340
 ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
None
 0.86A 4rzvA-2qluA:
6.8		 4rzvA-2qluA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 651
LYS A 653
ILE A 697
THR A 699
SER A 706
 PTR  A 701 ( 4.7A)
None
None
None
None
 0.52A 4rzvA-2qobA:
26.4		 4rzvA-2qobA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 651
LYS A 653
THR A 699
SER A 706
PHE A 765
 PTR  A 701 ( 4.7A)
None
None
None
None
 0.92A 4rzvA-2qobA:
26.4		 4rzvA-2qobA:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 705
LYS A 707
ILE A 751
THR A 753
SER A 760
 None
 0.72A 4rzvA-2r2pA:
7.6		 4rzvA-2r2pA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 651
LYS A 653
ILE A 697
THR A 699
SER A 706
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 4.5A)
 0.70A 4rzvA-2xyuA:
7.7		 4rzvA-2xyuA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 326
ILE A 374
SER A 383
PHE A 433
GLY A 462
 770  A 901 (-3.5A)
None
None
770  A 901 (-4.0A)
None
 0.36A 4rzvA-2z2wA:
22.4		 4rzvA-2z2wA:
27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 273
LYS A 275
ILE A 317
THR A 319
SER A 326
 None
 0.62A 4rzvA-2zv7A:
8.0		 4rzvA-2zv7A:
33.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 273
LYS A 275
THR A 319
SER A 326
PHE A 386
 None
 0.94A 4rzvA-2zv7A:
8.0		 4rzvA-2zv7A:
33.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		no annotation 5 ALA A 221
THR A 196
GLY A 225
PHE A 184
GLY A 188
 None
 0.93A 4rzvA-3aqoA:
undetectable		 4rzvA-3aqoA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
ILE A 264
THR A 266
SER A 273
PHE A 333
 None
 0.81A 4rzvA-3d7uA:
28.3		 4rzvA-3d7uA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 ALA A 237
LEU A  99
SER A  91
SER A  92
GLY A 163
 None
None
NA  A 519 ( 2.3A)
None
None
 0.96A 4rzvA-3ed4A:
undetectable		 4rzvA-3ed4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krt CROTONYL COA
REDUCTASE

(Streptomyces
coelicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 404
LEU A 181
ILE A  58
THR A 401
GLY A 122
 None
 0.97A 4rzvA-3krtA:
undetectable		 4rzvA-3krtA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
LYS A 667
ILE A 711
THR A 713
PHE A 779
 None
 0.71A 4rzvA-3kulA:
7.8		 4rzvA-3kulA:
33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
LYS A 667
ILE A 711
THR A 713
SER A 720
 None
 0.49A 4rzvA-3kulA:
7.8		 4rzvA-3kulA:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 6 ALA X 195
LEU X 150
SER X 206
SER X 209
GLY X 146
GLY X  92
 None
None
None
None
C8E  X 623 ( 3.7A)
C8E  X 623 ( 4.4A)
 1.48A 4rzvA-3kvnX:
undetectable		 4rzvA-3kvnX:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 LEU A 537
SER A 643
PHE A 642
GLY A 536
GLY A 531
 None
 0.97A 4rzvA-3l4kA:
undetectable		 4rzvA-3l4kA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln7 GLUTATHIONE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
GSHAB

(Pasteurella
multocida) 		PF02655
(ATP-grasp_3)
PF04262
(Glu_cys_ligase) 		5 ALA A 179
LEU A 267
SER A 235
PHE A 276
GLY A 280
 None
 0.84A 4rzvA-3ln7A:
undetectable		 4rzvA-3ln7A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 ALA A 229
LYS A 231
LEU A 259
THR A 279
SER A 286
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
None
 0.67A 4rzvA-3mdyA:
7.0		 4rzvA-3mdyA:
29.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 227
LYS A 229
LEU A 257
THR A 277
SER A 284
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
None
 0.76A 4rzvA-3my0A:
9.8		 4rzvA-3my0A:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 373
LEU A 406
ILE A 419
THR A 421
SER A 427
SER A 428
PHE A 475
 SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
None
SM5  A   1 (-3.0A)
 0.77A 4rzvA-3omvA:
12.9		 4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 373
LEU A 406
ILE A 419
THR A 421
TRP A 423
SER A 427
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-3.6A)
None
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-3.0A)
None
None
 0.85A 4rzvA-3omvA:
12.9		 4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 373
LEU A 406
THR A 421
TRP A 423
SER A 427
 SM5  A   1 (-3.6A)
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
None
 0.98A 4rzvA-3omvA:
12.9		 4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 373
LYS A 375
ILE A 419
THR A 421
SER A 427
SER A 428
PHE A 475
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
None
None
SM5  A   1 (-3.0A)
 0.80A 4rzvA-3omvA:
12.9		 4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 373
LYS A 375
ILE A 419
THR A 421
TRP A 423
SER A 427
PHE A 475
GLY A 485
PHE A 487
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-3.0A)
None
None
 0.87A 4rzvA-3omvA:
12.9		 4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 373
LYS A 375
ILE A 419
TRP A 423
SER A 427
PHE A 475
GLY A 485
GLY A 488
 SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 ( 4.3A)
SM5  A   1 (-4.3A)
None
SM5  A   1 (-3.0A)
None
None
 1.21A 4rzvA-3omvA:
12.9		 4rzvA-3omvA:
70.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
LYS A 578
ILE A 623
THR A 625
SER A 632
PHE A 695
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 ( 4.3A)
None
 0.84A 4rzvA-3ppzA:
8.3		 4rzvA-3ppzA:
36.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
LYS A 219
LEU A 247
THR A 267
SER A 274
PHE A 341
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
None
 0.96A 4rzvA-3q4tA:
25.4		 4rzvA-3q4tA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B 616
LYS B 618
ILE B 884
PHE B 942
GLY B 952
 None
 0.52A 4rzvA-3qd2B:
22.3		 4rzvA-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B 616
LYS B 618
PHE B 942
GLY B 952
PHE B 954
 None
 0.91A 4rzvA-3qd2B:
22.3		 4rzvA-3qd2B:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr5 PEPTIDE CHAIN
RELEASE FACTOR 3

(Coxiella
burnetii) 		PF00009
(GTP_EFTU)
PF16658
(RF3_C) 		5 ALA A 355
ILE A 360
PHE A 292
GLY A 294
PHE A 295
 None
 0.92A 4rzvA-3tr5A:
undetectable		 4rzvA-3tr5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		6 LEU A 423
SER A 314
SER A 313
PHE A 312
GLY A 420
GLY A 227
 LEU  A 423 ( 0.6A)
SER  A 314 ( 0.0A)
SER  A 313 ( 0.0A)
PHE  A 312 ( 1.3A)
GLY  A 420 ( 0.0A)
GLY  A 227 ( 0.0A)
 1.41A 4rzvA-3ulkA:
undetectable		 4rzvA-3ulkA:
20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1978
LYS A1980
LEU A2010
GLY A2101
PHE A2103
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
VGH  A3000 (-3.5A)
None
 0.97A 4rzvA-3zbfA:
10.5		 4rzvA-3zbfA:
30.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1978
LYS A1980
LEU A2010
ILE A2024
GLY A2101
 VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.8A)
None
VGH  A3000 (-3.5A)
 0.74A 4rzvA-3zbfA:
10.5		 4rzvA-3zbfA:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
LYS A  82
SER A 137
PHE A 183
GLY A 193
GLY A 196
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
None
 1.35A 4rzvA-4a4lA:
6.6		 4rzvA-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  80
LYS A  82
SER A 137
PHE A 183
GLY A 193
PHE A 195
 939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-3.5A)
939  A1331 (-4.0A)
None
None
 0.92A 4rzvA-4a4lA:
6.6		 4rzvA-4a4lA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
LYS A  91
ILE A 137
SER A 146
PHE A 192
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.61A 4rzvA-4b6lA:
23.9		 4rzvA-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  89
LYS A  91
SER A 146
PHE A 192
GLY A 202
PHE A 204
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 0.92A 4rzvA-4b6lA:
23.9		 4rzvA-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 233
LYS A 235
LEU A 263
THR A 283
SER A 290
 TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
None
 0.74A 4rzvA-4c02A:
7.3		 4rzvA-4c02A:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 LEU A 552
SER A 654
PHE A 653
GLY A 551
GLY A 546
 None
 0.98A 4rzvA-4fm9A:
undetectable		 4rzvA-4fm9A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwi ABC-TYPE
DIPEPTIDE/OLIGOPEPTI
DE/NICKEL TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		PF00005
(ABC_tran)
PF08352
(oligo_HPY) 		5 ALA B  24
LEU B  58
THR B  49
SER B  66
GLY B  62
 None
None
ATP  B 402 (-3.4A)
None
None
 0.98A 4rzvA-4fwiB:
undetectable		 4rzvA-4fwiB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A 429
LYS A 431
ILE A 469
SER A 478
GLY A 538
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.9A)
0WB  A 701 ( 4.4A)
None
 0.97A 4rzvA-4g3fA:
7.4		 4rzvA-4g3fA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		5 LEU A 537
SER A 643
PHE A 642
GLY A 536
GLY A 531
 None
 0.93A 4rzvA-4gfhA:
undetectable		 4rzvA-4gfhA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 ALA A 156
LYS A 158
THR A 205
SER A 212
GLY A 269
 None
 0.89A 4rzvA-4hzsA:
10.8		 4rzvA-4hzsA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 ALA A 156
THR A 205
SER A 212
GLY A 269
PHE A 271
 None
 0.62A 4rzvA-4hzsA:
10.8		 4rzvA-4hzsA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
LYS A 111
ILE A 157
SER A 166
PHE A 212
GLY A 222
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
None
1C7  A 401 (-4.0A)
None
 0.64A 4rzvA-4i6fA:
22.4		 4rzvA-4i6fA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
LYS A 111
SER A 166
PHE A 212
GLY A 222
GLY A 225
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.0A)
None
None
 1.28A 4rzvA-4i6fA:
22.4		 4rzvA-4i6fA:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
LYS A 111
SER A 166
PHE A 212
GLY A 222
PHE A 224
 1C7  A 401 (-3.2A)
1C7  A 401 ( 4.7A)
None
1C7  A 401 (-4.0A)
None
None
 0.94A 4rzvA-4i6fA:
22.4		 4rzvA-4i6fA:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 156
LYS A 158
THR A 205
SER A 212
GLY A 269
PHE A 271
 1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.3A)
None
1G0  A 401 ( 4.8A)
 1.10A 4rzvA-4id7A:
7.4		 4rzvA-4id7A:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 427
LYS A 429
ILE A 467
SER A 476
PHE A 535
 T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-3.8A)
None
 0.90A 4rzvA-4idtA:
7.3		 4rzvA-4idtA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 ALA A 110
SER A 221
GLY A 360
PHE A 361
GLY A 333
 None
 0.76A 4rzvA-4iviA:
undetectable		 4rzvA-4iviA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		6 ALA A  66
LYS A  68
SER A 123
PHE A 169
GLY A 179
PHE A 181
 None
 1.07A 4rzvA-4j7bA:
6.3		 4rzvA-4j7bA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  36
LYS A  38
SER A  93
PHE A 158
GLY A 159
 SU6  A 701 (-3.4A)
None
None
None
None
 0.85A 4rzvA-4jlcA:
21.4		 4rzvA-4jlcA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 293
LYS A 295
ILE A 336
SER A 345
PHE A 405
 0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.4A)
0J9  A 601 (-4.5A)
None
 0.95A 4rzvA-4k11A:
28.3		 4rzvA-4k11A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE

(Rhodococcus
opacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 ALA A 106
ILE A 309
THR A 109
SER A   9
GLY A  46
GLY A 355
 None
 1.31A 4rzvA-4m0xA:
undetectable		 4rzvA-4m0xA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
LYS A  51
LEU A  74
THR A  95
SER A 102
PHE A 162
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
ANP  A 401 (-3.6A)
None
 0.95A 4rzvA-4m69A:
7.8		 4rzvA-4m69A:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA B  51
LYS B  53
ILE B  97
SER B 106
PHE B 163
 ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 (-3.4A)
None
 0.77A 4rzvA-4o27B:
7.5		 4rzvA-4o27B:
29.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4our PHYTOCHROME B

(Arabidopsis
thaliana) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ALA B 203
LEU B 175
SER B 194
PHE B 167
PHE B 128
 None
 0.76A 4rzvA-4ourB:
undetectable		 4rzvA-4ourB:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pwn SERINE/THREONINE-PRO
TEIN KINASE WNK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 248
THR A 301
PHE A 356
GLY A 367
GLY A 370
 None
 0.95A 4rzvA-4pwnA:
8.6		 4rzvA-4pwnA:
32.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		6 ILE A  97
THR A 117
SER A 122
SER A 123
GLY A 100
GLY A  75
 None
 1.33A 4rzvA-4qwvA:
undetectable		 4rzvA-4qwvA:
23.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 ALA A  35
LYS A  37
ILE A  79
THR A  81
SER A  88
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-4.3A)
 0.58A 4rzvA-4ueuA:
11.4		 4rzvA-4ueuA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 ALA A  35
LYS A  37
THR A  81
SER A  88
PHE A 148
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-4.3A)
None
 0.92A 4rzvA-4ueuA:
11.4		 4rzvA-4ueuA:
36.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 ALA A 428
LYS A 430
ILE A 472
THR A 474
PHE A 540
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
None
 0.58A 4rzvA-4y93A:
11.3		 4rzvA-4y93A:
23.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 488
LYS A 490
ILE A 537
THR A 539
SER A 546
GLY A 608
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
None
None
 1.11A 4rzvA-4yffA:
25.7		 4rzvA-4yffA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 488
LYS A 490
THR A 539
SER A 546
PHE A 607
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-2.8A)
None
None
 0.91A 4rzvA-4yffA:
25.7		 4rzvA-4yffA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 481
LYS A 483
LEU A 514
ILE A 527
THR A 529
SER A 536
PHE A 583
GLY A 593
PHE A 595
GLY A 596
 5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 ( 4.0A)
5XJ  A 801 (-3.4A)
None
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
5XJ  A 801 (-3.7A)
5XJ  A 801 (-3.7A)
 0.66A 4rzvA-5fd2A:
14.0		 4rzvA-5fd2A:
93.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 481
LYS A 483
LEU A 514
ILE A 527
THR A 529
TRP A 531
PHE A 583
GLY A 593
PHE A 595
GLY A 596
 5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 ( 4.0A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
5XJ  A 801 (-3.7A)
5XJ  A 801 (-3.7A)
 0.53A 4rzvA-5fd2A:
14.0		 4rzvA-5fd2A:
93.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LYS A 483
LEU A 514
ILE A 527
THR A 529
SER A 535
SER A 536
PHE A 583
GLY A 593
PHE A 595
GLY A 596
 5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 ( 4.0A)
5XJ  A 801 (-3.4A)
None
None
5XJ  A 801 (-4.3A)
5XJ  A 801 ( 3.7A)
5XJ  A 801 (-3.7A)
5XJ  A 801 (-3.7A)
 0.71A 4rzvA-5fd2A:
14.0		 4rzvA-5fd2A:
93.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 LEU A 568
SER A 670
PHE A 669
GLY A 567
GLY A 562
 None
 0.98A 4rzvA-5gwjA:
undetectable		 4rzvA-5gwjA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 105
ILE A 146
THR A 148
SER A 155
GLY A 121
 None
 0.93A 4rzvA-5gz8A:
18.3		 4rzvA-5gz8A:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A  43
ILE A  80
THR A  82
SER A  86
PHE A 152
GLY A 153
 032  A 401 (-3.2A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
None
032  A 401 (-4.1A)
032  A 401 (-3.6A)
 1.46A 4rzvA-5hesA:
27.9		 4rzvA-5hesA:
32.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A  43
LYS A  45
ILE A  80
THR A  82
SER A  89
PHE A 152
GLY A 153
 032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.0A)
032  A 401 (-3.7A)
None
032  A 401 (-4.1A)
032  A 401 (-3.6A)
 0.58A 4rzvA-5hesA:
27.9		 4rzvA-5hesA:
32.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syd AZURIN, CHIMERIC
CONSTRUCT

(Pseudomonas
aeruginosa) 		PF00127
(Copper-bind) 		5 ILE A  47
THR A  44
SER A  97
PHE A 108
GLY A 102
 None
 0.91A 4rzvA-5sydA:
undetectable		 4rzvA-5sydA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 137
THR A 187
SER A 193
PHE A 240
GLY A 250
GLY A 253
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 1.11A 4rzvA-5vcxA:
5.4		 4rzvA-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 137
THR A 187
SER A 193
PHE A 240
GLY A 250
PHE A 252
 H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 ( 4.4A)
H8H  A 401 (-4.3A)
None
None
 0.78A 4rzvA-5vcxA:
5.4		 4rzvA-5vcxA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 239
ILE A 287
SER A 296
PHE A 346
GLY A 379
 8X7  A 501 ( 3.7A)
PO4  A 502 (-3.4A)
None
8X7  A 501 (-3.7A)
None
 0.70A 4rzvA-5vdkA:
22.4		 4rzvA-5vdkA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 5 ALA A 707
LYS A 709
ILE A 752
SER A 761
PHE A 823
 9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 ( 3.9A)
None
 0.97A 4rzvA-5vilA:
9.0		 4rzvA-5vilA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 6 ALA A  45
LYS A  47
LEU A  79
ILE A  93
THR A  95
SER A 102
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
 0.85A 4rzvA-5w5jA:
26.5		 4rzvA-5w5jA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 ALA A 917
LEU A 947
ILE A 961
THR A 963
PHE A1029
 ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
None
ANP  A1201 (-3.9A)
None
 0.57A 4rzvA-5wnoA:
27.9		 4rzvA-5wnoA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 5 LEU A 371
ILE A 170
PHE A 125
GLY A 368
GLY A 257
 None
None
None
HEM  A 501 (-3.5A)
HEM  A 501 (-3.3A)
 0.91A 4rzvA-5ysmA:
undetectable		 4rzvA-5ysmA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt7 -

(-) 		no annotation 5 ILE A 106
THR A 103
SER A  23
PHE A  34
GLY A  28
 None
None
NA  A 205 (-4.2A)
None
None
 0.81A 4rzvA-5yt7A:
undetectable		 4rzvA-5yt7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7q FLAGELLIN

(Bacillus cereus) 		no annotation 6 LEU A 136
ILE A 197
THR A 166
PHE A 135
GLY A  76
GLY A  81
 None
 1.48A 4rzvA-5z7qA:
undetectable		 4rzvA-5z7qA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 ALA A  54
ILE A  97
SER A 106
PHE A 165
GLY A 166
 ANP  A 501 ( 3.7A)
None
ANP  A 501 (-2.4A)
None
None
 0.77A 4rzvA-6ao5A:
13.1		 4rzvA-6ao5A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 ALA A 906
LYS A 908
SER A 963
GLY A1020
PHE A1022
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-3.3A)
None
None
 0.93A 4rzvA-6c7yA:
7.6		 4rzvA-6c7yA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 ALA A 217
LEU A 248
ILE A 262
THR A 264
SER A 271
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.4A)
 1.16A 4rzvA-6cz4A:
10.5		 4rzvA-6cz4A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 5 ALA A 545
LEU A 570
ILE A 559
THR A 561
GLY A 599
 None
 0.93A 4rzvA-6d6yA:
undetectable		 4rzvA-6d6yA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmi PROTEIN INHIBITOR OF
NEURONAL NITRIC
OXIDE SYNTHASE

(Homo sapiens) 		PF01221
(Dynein_light) 		4 ILE A  38
VAL A  58
PHE A  73
CYH A  24
 None
 1.31A 4rzvA-1cmiA:
undetectable		 4rzvA-1cmiA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cte CATHEPSIN B

(Rattus
norvegicus) 		PF00112
(Peptidase_C1) 		4 ILE A 201
VAL A 217
CYH A 240
HIS A 199
 PYS  A 255 (-4.6A)
None
None
PYS  A 255 ( 4.1A)
 1.13A 4rzvA-1cteA:
0.0		 4rzvA-1cteA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 4 ILE B 708
VAL B 768
PHE B 757
HIS B 710
 None
 1.36A 4rzvA-1ej6B:
0.0		 4rzvA-1ej6B:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ILE A 261
VAL A 262
PHE A 187
HIS A  26
 None
 1.26A 4rzvA-1flgA:
0.1		 4rzvA-1flgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		4 VAL A 235
PHE A 193
CYH A 267
HIS A 292
 None
 1.17A 4rzvA-1fs2A:
undetectable		 4rzvA-1fs2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 ILE A  67
VAL A 116
PHE A 185
HIS A 143
 None
 1.27A 4rzvA-1lzkA:
0.0		 4rzvA-1lzkA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk1 SEX COMB ON MIDLEG
CG9495-PA

(Drosophila
melanogaster) 		PF00536
(SAM_1) 		4 ILE B  26
VAL B  22
CYH B  73
HIS B  36
 None
 1.35A 4rzvA-1pk1B:
undetectable		 4rzvA-1pk1B:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 431
VAL A 349
PHE A 451
CYH A 309
 None
None
G24  A 462 (-4.7A)
None
 1.27A 4rzvA-1q4xA:
undetectable		 4rzvA-1q4xA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		4 ILE A  62
VAL A  33
PHE A  12
CYH A  69
 None
 1.38A 4rzvA-1q8kA:
undetectable		 4rzvA-1q8kA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj7 ECTODYSPLASIN A

(Homo sapiens) 		PF00229
(TNF) 		4 ILE A 369
VAL A 309
PHE A 379
HIS A 366
 None
 1.35A 4rzvA-1rj7A:
0.0		 4rzvA-1rj7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE A 709
VAL A 707
PHE A 732
CYH A 622
 None
 1.26A 4rzvA-1sb3A:
0.0		 4rzvA-1sb3A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmx HYDROXYQUINOL
1,2-DIOXYGENASE

(Pimelobacter
simplex) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ILE A 125
VAL A 155
PHE A 239
CYH A 134
 None
 1.03A 4rzvA-1tmxA:
undetectable		 4rzvA-1tmxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhd PUTATIVE
ACETYLTRANSFERASE/AC
YLTRANSFERASE

(Bacillus cereus) 		PF00132
(Hexapep) 		4 ILE A  84
PHE A 113
CYH A  88
HIS A  64
 None
None
None
SO4  A 201 (-3.6A)
 1.36A 4rzvA-1xhdA:
undetectable		 4rzvA-1xhdA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		5 ILE A 102
VAL A 132
PHE A  80
CYH A  75
HIS A  39
 None
 1.48A 4rzvA-1xtzA:
undetectable		 4rzvA-1xtzA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 ILE A 508
VAL A 498
PHE A 371
HIS A 478
 None
 1.33A 4rzvA-1yvpA:
undetectable		 4rzvA-1yvpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 ILE A 509
VAL A 512
PHE A 562
HIS A 542
 None
 1.35A 4rzvA-1z1wA:
undetectable		 4rzvA-1z1wA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ILE A 697
VAL A 647
PHE A 641
HIS A 743
 None
 1.20A 4rzvA-1z68A:
undetectable		 4rzvA-1z68A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		4 ILE A  88
VAL A  24
PHE A  44
HIS A  85
 None
 1.33A 4rzvA-1zoiA:
undetectable		 4rzvA-1zoiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME

(Homo sapiens) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		4 ILE A 368
VAL A 314
PHE A 363
CYH A 392
 None
 1.31A 4rzvA-1zxnA:
undetectable		 4rzvA-1zxnA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axc COLICIN E7

(Escherichia
coli) 		PF03515
(Cloacin) 		4 ILE A 267
VAL A 278
PHE A  87
HIS A 216
 None
 1.03A 4rzvA-2axcA:
undetectable		 4rzvA-2axcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 ILE A 177
VAL A 123
PHE A 147
HIS A 207
 None
None
None
SF4  A1000 (-4.1A)
 1.15A 4rzvA-2b3xA:
undetectable		 4rzvA-2b3xA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE

(Podophyllum
peltatum) 		PF13561
(adh_short_C2) 		4 ILE A  87
VAL A 139
PHE A 130
HIS A  90
 None
 1.35A 4rzvA-2bgkA:
undetectable		 4rzvA-2bgkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ILE A 110
VAL A 109
PHE A 121
HIS A  72
 None
None
None
FAD  A 600 (-2.4A)
 1.33A 4rzvA-2bvgA:
undetectable		 4rzvA-2bvgA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwf DELTA1-PIPERIDEINE-2
-CARBOXYLATE
REDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF02615
(Ldh_2) 		4 ILE A 327
VAL A  13
CYH A  43
HIS A  52
 None
 1.19A 4rzvA-2cwfA:
undetectable		 4rzvA-2cwfA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhn 7,8-DIHYDRONEOPTERIN
ALDOLASE

(Staphylococcus
aureus) 		PF02152
(FolB) 		4 ILE A  64
VAL A  61
PHE A   6
HIS A  75
 None
 1.20A 4rzvA-2dhnA:
undetectable		 4rzvA-2dhnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 ILE A  47
VAL A  57
PHE A 113
HIS A  45
 None
 0.98A 4rzvA-2e3jA:
undetectable		 4rzvA-2e3jA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		4 ILE A 313
VAL A  25
PHE A  84
HIS A  41
 None
 1.22A 4rzvA-2f8qA:
undetectable		 4rzvA-2f8qA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gry KINESIN-LIKE PROTEIN
KIF2

(Homo sapiens) 		PF00225
(Kinesin) 		4 ILE A 274
VAL A 271
PHE A 265
CYH A 282
 None
 1.36A 4rzvA-2gryA:
undetectable		 4rzvA-2gryA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3b HUMAN CANCER-RELATED
NTPASE

(Homo sapiens) 		PF03266
(NTPase_1) 		4 ILE A 157
VAL A 154
PHE A 120
HIS A   3
 None
 1.24A 4rzvA-2i3bA:
undetectable		 4rzvA-2i3bA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uwf ALKALINE ACTIVE
ENDOXYLANASE

(Bacillus
halodurans) 		PF00331
(Glyco_hydro_10) 		4 ILE A 319
VAL A  35
PHE A  94
HIS A  51
 None
 1.20A 4rzvA-2uwfA:
undetectable		 4rzvA-2uwfA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whd THIOREDOXIN
REDUCTASE

(Hordeum vulgare) 		PF07992
(Pyr_redox_2) 		4 ILE A  15
VAL A  13
CYH A 310
HIS A  23
 None
 1.28A 4rzvA-2whdA:
undetectable		 4rzvA-2whdA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xbl PHOSPHOHEPTOSE
ISOMERASE

(Burkholderia
pseudomallei) 		PF13580
(SIS_2) 		4 ILE A 120
VAL A  50
PHE A 194
HIS A 178
 None
 1.28A 4rzvA-2xblA:
undetectable		 4rzvA-2xblA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xci 3-DEOXY-D-MANNO-2-OC
TULOSONIC ACID
TRANSFERASE

(Aquifex
aeolicus) 		PF04413
(Glycos_transf_N) 		4 ILE A  95
VAL A 116
PHE A 163
HIS A  46
 None
 1.28A 4rzvA-2xciA:
undetectable		 4rzvA-2xciA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 180
VAL A 178
PHE A 164
HIS A 142
 None
 1.32A 4rzvA-2yxxA:
undetectable		 4rzvA-2yxxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ILE A 414
VAL A 415
PHE A 368
HIS A 303
 None
 1.25A 4rzvA-2zr2A:
1.7		 4rzvA-2zr2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ILE A  22
VAL A 119
PHE A 135
CYH A  40
 None
 1.22A 4rzvA-3eh7A:
undetectable		 4rzvA-3eh7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gde DNA LIGASE

(Archaeoglobus
fulgidus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A 193
VAL A 223
PHE A 336
CYH A 346
 None
 1.14A 4rzvA-3gdeA:
undetectable		 4rzvA-3gdeA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ILE A 374
VAL A 297
PHE A 201
HIS A 462
 None
 1.23A 4rzvA-3h8fA:
undetectable		 4rzvA-3h8fA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9

(Thermus
thermophilus) 		PF12838
(Fer4_7) 		4 ILE 9  68
VAL 9  70
CYH 9 108
HIS 9  41
 SF4  9 183 (-4.8A)
None
SF4  9 184 (-2.3A)
SF4  9 183 (-4.5A)
 1.09A 4rzvA-3i9v9:
undetectable		 4rzvA-3i9v9:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 ILE B  72
VAL B  71
CYH B   8
HIS B  15
 None
 1.35A 4rzvA-3iqdB:
0.9		 4rzvA-3iqdB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis) 		PF00303
(Thymidylat_synt) 		4 ILE A 170
VAL A 174
PHE A  42
HIS A  10
 None
 1.33A 4rzvA-3ix6A:
undetectable		 4rzvA-3ix6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvo GP6

(Escherichia
virus HK97) 		PF05135
(Phage_connect_1) 		4 ILE A  55
VAL A   8
CYH A  40
HIS A  95
 None
 1.30A 4rzvA-3jvoA:
undetectable		 4rzvA-3jvoA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyg UNCHARACTERIZED
PROTEIN

(Wolinella
succinogenes) 		PF01242
(PTPS) 		4 ILE A  80
VAL A 131
CYH A  12
HIS A  38
 None
None
None
ZN  A 200 (-3.3A)
 1.31A 4rzvA-3jygA:
undetectable		 4rzvA-3jygA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		4 VAL A 339
PHE A 394
CYH A 355
HIS A 360
 None
 1.30A 4rzvA-3jz4A:
undetectable		 4rzvA-3jz4A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ILE A 113
VAL A  37
PHE A  60
HIS A 282
 None
 1.14A 4rzvA-3lpdA:
undetectable		 4rzvA-3lpdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 ILE A 175
VAL A 174
PHE A 143
CYH A 246
 None
 1.33A 4rzvA-3oh8A:
undetectable		 4rzvA-3oh8A:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 355
VAL A 363
PHE A 408
CYH A 424
 SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
None
SM5  A   1 ( 4.4A)
 0.46A 4rzvA-3omvA:
12.9		 4rzvA-3omvA:
70.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmq DECAHEME CYTOCHROME
C MTRF

(Shewanella
oneidensis) 		no annotation 4 ILE A 468
VAL A 467
CYH A 546
HIS A 527
 HEC  A 675 ( 4.2A)
HEC  A 677 (-4.4A)
HEC  A 677 (-1.8A)
HEC  A 675 ( 3.0A)
 0.90A 4rzvA-3pmqA:
undetectable		 4rzvA-3pmqA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poy NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 ILE A 559
VAL A 649
PHE A 564
HIS A 549
 None
 1.35A 4rzvA-3poyA:
undetectable		 4rzvA-3poyA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A  12
VAL A   7
PHE A 101
HIS A  14
 None
 1.09A 4rzvA-3pwzA:
undetectable		 4rzvA-3pwzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		4 ILE B 494
PHE B 501
CYH B 412
HIS B  66
 None
 1.22A 4rzvA-3q75B:
undetectable		 4rzvA-3q75B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4i CITRATE LYASE

(Paraburkholderia
xenovorans) 		PF03328
(HpcH_HpaI) 		4 ILE A 261
VAL A 262
PHE A  80
HIS A 222
 None
 1.07A 4rzvA-3r4iA:
undetectable		 4rzvA-3r4iA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjs DYNEIN LIGHT CHAIN
MOTOR PROTEIN

(Toxoplasma
gondii) 		PF01221
(Dynein_light) 		4 ILE A  38
VAL A  58
PHE A  73
CYH A  24
 None
 1.13A 4rzvA-3rjsA:
undetectable		 4rzvA-3rjsA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 ILE L 372
VAL L 375
PHE L 346
HIS L 446
 None
 1.38A 4rzvA-3rkoL:
1.6		 4rzvA-3rkoL:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssm METHYLTRANSFERASE

(Micromonospora
griseorubida) 		no annotation 4 ILE A 271
VAL A 200
PHE A 110
HIS A 189
 None
 1.16A 4rzvA-3ssmA:
undetectable		 4rzvA-3ssmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ILE A 632
VAL A 702
PHE A 694
HIS A 665
 None
 1.35A 4rzvA-3thzA:
undetectable		 4rzvA-3thzA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		4 ILE A 113
VAL A  37
PHE A  60
HIS A 282
 None
 1.20A 4rzvA-3ti7A:
undetectable		 4rzvA-3ti7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		4 ILE A 430
VAL A 433
PHE A 439
CYH A 386
 HEC  A 904 ( 3.9A)
HEC  A 904 ( 3.9A)
HEC  A 905 (-4.5A)
HEC  A 904 (-1.8A)
 1.23A 4rzvA-3ufkA:
undetectable		 4rzvA-3ufkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		4 ILE A 648
VAL A 647
CYH A 751
HIS A 728
 HEC  A 906 ( 3.8A)
HEC  A 909 (-4.6A)
HEC  A 909 (-1.9A)
HEC  A 906 ( 3.1A)
 1.01A 4rzvA-3ufkA:
undetectable		 4rzvA-3ufkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		4 ILE A  32
VAL A   3
CYH A  18
HIS A  24
 None
 1.33A 4rzvA-3w4kA:
undetectable		 4rzvA-3w4kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 4 ILE B 444
VAL B 442
PHE B 574
HIS B 450
 None
 1.32A 4rzvA-3x17B:
undetectable		 4rzvA-3x17B:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		4 ILE A 134
VAL A 102
PHE A  82
CYH A 129
 None
 1.12A 4rzvA-4dppA:
undetectable		 4rzvA-4dppA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 ILE A 357
VAL A 305
PHE A 352
CYH A 381
 None
 1.21A 4rzvA-4gfhA:
undetectable		 4rzvA-4gfhA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2d NADPH-DEPENDENT
DIFLAVIN
OXIDOREDUCTASE 1

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		4 ILE A  55
VAL A  54
PHE A  76
CYH A  58
 None
 1.36A 4rzvA-4h2dA:
undetectable		 4rzvA-4h2dA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilk STARVATION SENSING
PROTEIN RSPB

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  43
VAL A 111
CYH A  37
HIS A  47
 None
None
MN  A 402 (-3.2A)
None
 1.15A 4rzvA-4ilkA:
undetectable		 4rzvA-4ilkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 ILE A 251
VAL A 105
PHE A 187
HIS A 249
 None
 1.20A 4rzvA-4j5uA:
undetectable		 4rzvA-4j5uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mob ACYL-COENZYME A
THIOESTERASE 12

(Homo sapiens) 		PF03061
(4HBT) 		4 ILE A  71
VAL A  91
PHE A 108
HIS A  19
 None
 1.25A 4rzvA-4mobA:
undetectable		 4rzvA-4mobA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 ILE A 219
VAL A 269
PHE A  76
HIS A 214
 None
 1.32A 4rzvA-4n0rA:
undetectable		 4rzvA-4n0rA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbw SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Plesiocystis
pacifica) 		PF13561
(adh_short_C2) 		4 ILE A  83
VAL A  80
PHE A 134
HIS A  38
 None
 1.35A 4rzvA-4nbwA:
undetectable		 4rzvA-4nbwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		4 ILE A 207
VAL A 210
PHE A 217
CYH A 223
 None
 1.34A 4rzvA-4nj5A:
undetectable		 4rzvA-4nj5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oue PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 ILE A 206
VAL A 207
PHE A 217
HIS A 170
 None
 1.38A 4rzvA-4oueA:
undetectable		 4rzvA-4oueA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		4 ILE A 318
VAL A  34
PHE A  94
HIS A  51
 None
 1.24A 4rzvA-4pueA:
undetectable		 4rzvA-4pueA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 ILE A  23
VAL A  89
PHE A 166
CYH A 185
 None
 1.23A 4rzvA-4weoA:
undetectable		 4rzvA-4weoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woj ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Francisella
tularensis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 131
VAL A 110
CYH A  72
HIS A  82
 None
 1.38A 4rzvA-4wojA:
undetectable		 4rzvA-4wojA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28

(Cytomegalovirus) 		PF00001
(7tm_1) 		4 ILE A 204
VAL A 203
CYH A 120
HIS A 283
 None
UNL  A 409 ( 4.2A)
SIN  A 416 ( 4.0A)
None
 1.33A 4rzvA-4xt1A:
undetectable		 4rzvA-4xt1A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqd ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00989
(PAS)
PF08447
(PAS_3) 		4 ILE B 223
VAL B 101
PHE B 134
CYH B 195
 None
 1.27A 4rzvA-4zqdB:
undetectable		 4rzvA-4zqdB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ILE A 485
VAL A 482
PHE A  20
HIS A 645
 None
 1.33A 4rzvA-5a31A:
undetectable		 4rzvA-5a31A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		4 ILE A 129
PHE A 423
CYH A 207
HIS A 127
 None
 1.14A 4rzvA-5d2eA:
undetectable		 4rzvA-5d2eA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		4 ILE A  87
VAL A 115
CYH A  80
HIS A  89
 None
 1.01A 4rzvA-5dpdA:
2.2		 4rzvA-5dpdA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpd PROTEIN LYSINE
METHYLTRANSFERASE 1

(Rickettsia
prowazekii) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		4 ILE A  87
VAL A 115
CYH A  80
HIS A 478
 None
 1.32A 4rzvA-5dpdA:
2.2		 4rzvA-5dpdA:
18.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 463
VAL A 471
PHE A 516
CYH A 532
 5XJ  A 801 ( 4.7A)
5XJ  A 801 (-4.6A)
None
5XJ  A 801 (-4.6A)
 0.54A 4rzvA-5fd2A:
14.0		 4rzvA-5fd2A:
93.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 471
PHE A 516
CYH A 532
HIS A 539
 5XJ  A 801 (-4.6A)
None
5XJ  A 801 (-4.6A)
None
 0.98A 4rzvA-5fd2A:
14.0		 4rzvA-5fd2A:
93.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtk BETAINE-ALDEHYDE
DEHYDROGENASE

(Bacillus cereus) 		PF00171
(Aldedh) 		4 ILE A 237
VAL A 161
PHE A 212
HIS A 235
 None
 1.39A 4rzvA-5gtkA:
undetectable		 4rzvA-5gtkA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 ILE A 158
VAL A 159
PHE A 138
HIS A 466
 None
 1.28A 4rzvA-5hmpA:
undetectable		 4rzvA-5hmpA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		4 ILE A 181
VAL A 186
PHE A 213
CYH A 158
 None
 1.32A 4rzvA-5hstA:
undetectable		 4rzvA-5hstA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER

(Homo sapiens) 		PF00209
(SNF) 		4 ILE A  93
VAL A  92
PHE A 334
CYH A 369
 None
 1.07A 4rzvA-5i6zA:
0.2		 4rzvA-5i6zA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilg PHOTORECEPTOR
DEHYDROGENASE,
ISOFORM C

(Drosophila
melanogaster) 		PF00106
(adh_short) 		4 ILE A  17
VAL A  90
PHE A 160
CYH A 181
 NAD  A 302 (-3.8A)
None
None
None
 1.25A 4rzvA-5ilgA:
undetectable		 4rzvA-5ilgA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		4 ILE A 189
VAL A 159
PHE A 124
CYH A 243
 None
 0.98A 4rzvA-5iw7A:
undetectable		 4rzvA-5iw7A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A 419
VAL A 446
PHE A 397
HIS A 432
 None
 0.88A 4rzvA-5iy9A:
1.2		 4rzvA-5iy9A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ILE A 271
VAL A 656
PHE A 227
HIS A 646
 None
 1.06A 4rzvA-5jxkA:
2.1		 4rzvA-5jxkA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1q METHYL-COENZYME M
REDUCTASE III FROM
METHANOTHERMOCOCCUS
THERMOLITHOTROPHICUS
SUBUNIT BETA

(Methanothermococcus
thermolithotrophicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ILE B 315
VAL B 314
PHE B 375
CYH B 398
 None
 1.34A 4rzvA-5n1qB:
undetectable		 4rzvA-5n1qB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(Methanotorris
formicicus) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ILE B 316
VAL B 315
PHE B 376
CYH B 399
 None
 1.36A 4rzvA-5n28B:
undetectable		 4rzvA-5n28B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 4 ILE A 454
VAL A 450
PHE A 415
CYH A 410
 None
 1.35A 4rzvA-5t3bA:
undetectable		 4rzvA-5t3bA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN

(Human
betaherpesvirus
5;
Lama glama) 		no annotation 4 ILE A 204
VAL A 203
CYH A 120
HIS A 283
 None
 1.33A 4rzvA-5wb1A:
0.7		 4rzvA-5wb1A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wfc HISTONE-LYSINE-N-MET
HYLTRANSFERASE EZH2,
POLYCOMB PROTEIN
SUZ12 CHIMERA

(Chaetomium
thermophilum) 		no annotation 4 ILE B2669
VAL B2668
CYH B 570
HIS B 567
 None
None
ZN  B8008 (-2.2A)
None
 1.37A 4rzvA-5wfcB:
undetectable		 4rzvA-5wfcB:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wof DYNEIN LIGHT CHAIN
1, PUTATIVE

(Plasmodium
falciparum) 		PF01221
(Dynein_light) 		4 ILE A  32
VAL A  52
PHE A  67
CYH A  18
 None
 1.32A 4rzvA-5wofA:
undetectable		 4rzvA-5wofA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1

(Yarrowia
lipolytica) 		no annotation 4 ILE A 233
VAL A 231
PHE A 215
HIS A 192
 None
 1.23A 4rzvA-5y9dA:
undetectable		 4rzvA-5y9dA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnf PHOSPHOETHANOLAMINE
TRANSFERASE

(Moraxella sp.
HMSC061H09) 		no annotation 4 ILE A 421
VAL A 268
PHE A 573
HIS A 414
 None
 1.35A 4rzvA-6bnfA:
undetectable		 4rzvA-6bnfA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 ILE A 157
VAL A 137
PHE A 241
CYH A 128
 None
None
None
GOL  A 503 (-3.0A)
 1.38A 4rzvA-6enoA:
undetectable		 4rzvA-6enoA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhf -

(-) 		no annotation 4 ILE A 321
VAL A  34
PHE A  94
HIS A  51
 None
 1.16A 4rzvA-6fhfA:
undetectable		 4rzvA-6fhfA:
undetectable