SIMILAR PATTERNS OF AMINO ACIDS FOR 4RZ7_A_1E8A901_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 ILE A 503
ALA A 499
ILE A 532
LEU A 205
VAL A 202
 None
 1.03A 4rz7A-1d6mA:
0.0		 4rz7A-1d6mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ILE A 201
ALA A 220
LYS A 222
THR A 266
LEU A 321
 None
 0.70A 4rz7A-1k9aA:
18.3		 4rz7A-1k9aA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  34
ALA A  55
LYS A  57
ILE A  89
LEU A 158
 None
 0.61A 4rz7A-1u5qA:
9.7		 4rz7A-1u5qA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ILE A 251
ALA A 272
LYS A 274
PHE A 321
VAL A 326
LEU A 376
 BI1  A1000 (-3.9A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
None
BI1  A1000 (-3.9A)
BI1  A1000 (-4.8A)
 0.59A 4rz7A-1zrzA:
12.4		 4rz7A-1zrzA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
ILE A  77
LEU A  95
VAL A  96
 None
 0.43A 4rz7A-1zwsA:
28.7		 4rz7A-1zwsA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
ILE A  77
LEU A  95
VAL A  96
 GOL  A3001 (-3.5A)
None
GOL  A3001 (-4.8A)
None
GOL  A3001 (-3.8A)
 0.54A 4rz7A-2a2aA:
10.6		 4rz7A-2a2aA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  52
ALA A  73
LYS A  75
LEU A 121
LEU A 172
 None
5ID  A1300 ( 3.8A)
None
5ID  A1300 (-4.5A)
5ID  A1300 (-4.6A)
 0.58A 4rz7A-2c47A:
22.6		 4rz7A-2c47A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		5 ILE A  18
ALA A  39
LYS A  41
LEU A  87
LEU A 138
 CKI  A 300 (-4.1A)
CKI  A 300 (-3.6A)
None
None
CKI  A 300 (-4.4A)
 0.41A 4rz7A-2csnA:
23.3		 4rz7A-2csnA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  34
ALA A  55
LYS A  57
ILE A  89
LEU A 158
 STU  A 400 (-4.2A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 ( 4.5A)
STU  A 400 ( 4.6A)
 0.85A 4rz7A-2gcdA:
10.6		 4rz7A-2gcdA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 635
ALA A 659
LYS A 661
ILE A 691
THR A 707
 ADP  A 400 (-4.9A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
None
ADP  A 400 (-4.7A)
 0.72A 4rz7A-2henA:
7.5		 4rz7A-2henA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 ILE A 428
ALA A 452
LYS A 454
LEU A 501
LEU A 553
 4ST  A1687 (-4.2A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.4A)
 0.61A 4rz7A-2j0jA:
9.1		 4rz7A-2j0jA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  50
LYS A  52
LEU A 100
VAL A 101
LEU A 151
 J60  A1305 (-3.3A)
EDO  A1304 ( 2.9A)
J60  A1305 (-4.4A)
J60  A1305 (-3.9A)
None
 0.85A 4rz7A-2jamA:
6.1		 4rz7A-2jamA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  50
LYS A  52
LEU A 100
VAL A 101
LEU A 151
 QPP  A1314 ( 3.7A)
None
QPP  A1314 (-4.5A)
QPP  A1314 (-4.0A)
None
 0.66A 4rz7A-2jc6A:
23.7		 4rz7A-2jc6A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 ALA A 182
THR A 112
ILE A 125
THR A 150
LEU A 127
 None
 0.93A 4rz7A-2o7qA:
undetectable		 4rz7A-2o7qA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 ALA A  46
LYS A  48
ILE A  87
LEU A 105
LEU A 156
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 0.57A 4rz7A-2phkA:
24.0		 4rz7A-2phkA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		7 ILE A 428
ALA A 449
LYS A 451
ILE A 477
THR A 493
LEU A 495
LEU A 546
 None
 0.59A 4rz7A-2qr7A:
6.1		 4rz7A-2qr7A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 ILE A 490
ALA A 509
LYS A 511
ILE A 557
LEU A 656
 None
5ID  A1800 (-3.4A)
IOD  A1799 (-3.2A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.5A)
 0.55A 4rz7A-2vuwA:
15.3		 4rz7A-2vuwA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
ILE A  77
LEU A  95
VAL A  96
 ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.2A)
None
ADP  A1303 (-3.6A)
 0.67A 4rz7A-2w4kA:
10.8		 4rz7A-2w4kA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  73
LYS A  75
ILE A 102
LEU A 120
VAL A 121
LEU A 171
 DKI  A1338 ( 3.7A)
None
DKI  A1338 ( 4.4A)
DKI  A1338 (-4.2A)
DKI  A1338 (-3.9A)
DKI  A1338 (-4.9A)
 0.63A 4rz7A-2w4oA:
9.4		 4rz7A-2w4oA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 424
ALA A 445
LYS A 447
ILE A 473
THR A 489
LEU A 491
LEU A 542
 None
 0.53A 4rz7A-2wntA:
22.7		 4rz7A-2wntA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 133
LYS A 135
ILE A 164
VAL A 183
LEU A 234
 16X  A1374 ( 3.8A)
16X  A1374 ( 4.3A)
None
16X  A1374 (-4.0A)
16X  A1374 ( 4.8A)
 0.82A 4rz7A-2x4fA:
20.7		 4rz7A-2x4fA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 627
ALA A 651
LYS A 653
ILE A 683
THR A 699
 None
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
 0.48A 4rz7A-2xyuA:
7.9		 4rz7A-2xyuA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  30
ALA A  51
LYS A  53
ILE A  91
LEU A 109
LEU A 160
 B49  A1294 (-3.9A)
B49  A1294 (-3.2A)
None
B49  A1294 ( 4.6A)
B49  A1294 ( 4.7A)
B49  A1294 (-4.4A)
 0.60A 4rz7A-2y7jA:
11.7		 4rz7A-2y7jA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
ILE A  77
LEU A  95
VAL A  96
 AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.8A)
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.9A)
 0.59A 4rz7A-2yabA:
10.8		 4rz7A-2yabA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ILE A 576
THR A 712
ILE A 648
PHE A 588
LEU A 651
 None
 0.96A 4rz7A-3b2rA:
undetectable		 4rz7A-3b2rA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ILE A 576
THR A 712
ILE A 648
PHE A 588
LEU A 651
 None
 0.91A 4rz7A-3bjcA:
undetectable		 4rz7A-3bjcA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
ILE A  77
LEU A  95
VAL A  96
 4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
4RB  A 401 ( 4.3A)
4RB  A 401 (-4.4A)
4RB  A 401 ( 4.1A)
 0.45A 4rz7A-3bqrA:
6.9		 4rz7A-3bqrA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 201
ALA A 220
LYS A 222
THR A 266
LEU A 321
 None
 0.70A 4rz7A-3d7uA:
8.0		 4rz7A-3d7uA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  23
ALA A  44
LYS A  46
LEU A  94
LEU A 153
 ANP  A   1 (-4.2A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
 0.76A 4rz7A-3dakA:
6.4		 4rz7A-3dakA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  32
ALA A  53
LYS A  55
ILE A  86
LEU A 110
 35F  A   1 ( 4.4A)
35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
None
35F  A   1 (-4.5A)
 0.44A 4rz7A-3e7oA:
8.3		 4rz7A-3e7oA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ILE A  34
ALA A  55
LYS A  57
ILE A  86
LEU A 104
LEU A 155
 DRK  A   1 (-4.2A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 ( 4.8A)
DRK  A   1 (-4.4A)
DRK  A   1 (-4.6A)
 0.52A 4rz7A-3f3zA:
11.3		 4rz7A-3f3zA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		5 ALA A  58
THR A 435
ILE A 439
LEU A  63
VAL A  68
 None
 1.02A 4rz7A-3fw6A:
2.7		 4rz7A-3fw6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  51
LYS A  53
ILE A  84
THR A 106
LEU A 108
 NIL  A   1 (-3.7A)
None
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 ( 4.4A)
 0.55A 4rz7A-3gp0A:
8.0		 4rz7A-3gp0A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ILE A  16
ALA A  37
LYS A  39
LEU A  91
LEU A 182
 ANP  A 329 ( 4.2A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-2.7A)
ANP  A 329 ( 4.7A)
ANP  A 329 (-4.4A)
 0.74A 4rz7A-3hkoA:
9.2		 4rz7A-3hkoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		5 ALA A  40
LYS A  42
LEU A  91
VAL A  92
LEU A 142
 None
 0.70A 4rz7A-3kl8A:
11.4		 4rz7A-3kl8A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 ALA A 700
LYS A 702
ILE A 729
LEU A 747
LEU A 804
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
ADP  A2101 (-4.4A)
 0.81A 4rz7A-3lj0A:
8.3		 4rz7A-3lj0A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		5 ALA A  45
THR A  64
LEU A  91
VAL A  82
LEU A  76
 None
 0.94A 4rz7A-3lstA:
undetectable		 4rz7A-3lstA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 ILE A 210
ALA A 229
LYS A 231
THR A 279
LEU A 339
 LDN  A   1 (-4.1A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
 0.68A 4rz7A-3mdyA:
7.9		 4rz7A-3mdyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		5 ALA A  52
LYS A  54
ILE A  85
THR A 107
LEU A 109
 1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
 0.43A 4rz7A-3ohtA:
17.0		 4rz7A-3ohtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ILE A 557
ALA A 576
LYS A 578
THR A 625
LEU A 683
 STU  A   1 (-4.1A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.65A 4rz7A-3ppzA:
8.6		 4rz7A-3ppzA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5p MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR

(Bacillus
subtilis) 		PF06445
(GyrI-like)
PF13411
(MerR_1) 		6 ALA A 150
THR A 192
ILE A 190
LEU A 148
VAL A 147
LEU A 142
 None
None
None
None
TAC  A7101 (-4.1A)
None
 1.49A 4rz7A-3q5pA:
undetectable		 4rz7A-3q5pA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 110
ALA A 113
THR A 301
LEU A  35
LEU A   7
 None
 1.02A 4rz7A-3qldA:
undetectable		 4rz7A-3qldA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 382
LYS A 384
PHE A 431
VAL A 436
LEU A 486
 07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
07U  A   1 (-3.8A)
07U  A   1 (-4.3A)
 0.48A 4rz7A-3txoA:
29.4		 4rz7A-3txoA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 625
ALA A 649
LYS A 651
ILE A 681
THR A 697
 None
 0.64A 4rz7A-3zfxA:
7.4		 4rz7A-3zfxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A  97
ALA A 121
LYS A 123
ILE A 153
THR A 169
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.8A)
 0.59A 4rz7A-4aw5A:
7.8		 4rz7A-4aw5A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A  97
ALA A 121
LYS A 123
THR A 169
LEU A 223
 30K  A1365 (-4.5A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 0.82A 4rz7A-4aw5A:
7.8		 4rz7A-4aw5A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  61
ALA A  82
LYS A  84
ILE A 115
LEU A 139
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.9A)
R4L  A1394 ( 4.9A)
 0.69A 4rz7A-4b99A:
7.6		 4rz7A-4b99A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  61
ALA A  82
LYS A  84
LEU A 139
LEU A 189
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 ( 4.9A)
R4L  A1394 (-4.5A)
 0.57A 4rz7A-4b99A:
7.6		 4rz7A-4b99A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		5 ALA A 267
LYS A 269
ILE A 302
PHE A 316
LEU A 371
 None
 0.58A 4rz7A-4c0tA:
9.6		 4rz7A-4c0tA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ALA A  43
LYS A  45
ILE A  77
VAL A  96
LEU A 146
 STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
 0.87A 4rz7A-4cfhA:
11.1		 4rz7A-4cfhA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 653
LYS A 655
ILE A 685
THR A 701
LEU A 773
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
 0.89A 4rz7A-4ckrA:
7.1		 4rz7A-4ckrA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ILE A  17
ALA A  38
LYS A  40
VAL A  91
LEU A 141
 None
 1.03A 4rz7A-4d28A:
11.7		 4rz7A-4d28A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ILE A 567
ALA A 588
LEU A 638
VAL A 639
LEU A 690
 GUI  A 901 (-4.0A)
GUI  A 901 (-3.4A)
GUI  A 901 (-4.4A)
GUI  A 901 (-4.0A)
GUI  A 901 (-4.3A)
 0.68A 4rz7A-4e93A:
18.2		 4rz7A-4e93A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  19
ALA A  41
LYS A  43
VAL A 101
LEU A 152
 0RS  A 900 (-4.1A)
0RS  A 900 ( 3.7A)
0RS  A 900 (-3.3A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.3A)
 1.02A 4rz7A-4ez5A:
10.5		 4rz7A-4ez5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
LYS A  49
LEU A  97
VAL A  98
LEU A 148
 ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 ( 4.8A)
ATP  A 401 (-3.9A)
ATP  A 401 (-4.6A)
 0.48A 4rz7A-4fg8A:
9.7		 4rz7A-4fg8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A  29
ALA A  50
LYS A  52
LEU A 102
LEU A 153
 STU  A 401 (-4.1A)
STU  A 401 (-3.2A)
None
STU  A 401 (-4.4A)
STU  A 401 (-4.7A)
 0.81A 4rz7A-4fr4A:
9.4		 4rz7A-4fr4A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huz 2,6-DICHLORO-P-HYDRO
QUINONE
1,2-DIOXYGENASE

(Sphingobium
chlorophenolicum) 		PF00903
(Glyoxalase) 		6 ILE A 318
ALA A  19
THR A  71
ILE A  47
LEU A  50
LEU A  39
 None
 1.26A 4rz7A-4huzA:
undetectable		 4rz7A-4huzA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 ALA A 156
LYS A 158
ILE A 190
THR A 205
LEU A 207
 None
 0.99A 4rz7A-4hzsA:
10.6		 4rz7A-4hzsA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 ALA A 156
LYS A 158
THR A 205
LEU A 207
LEU A 259
 None
 0.75A 4rz7A-4hzsA:
10.6		 4rz7A-4hzsA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 156
LYS A 158
ILE A 190
THR A 205
LEU A 207
LEU A 259
 1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 (-4.6A)
 0.81A 4rz7A-4id7A:
7.7		 4rz7A-4id7A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iiw LMO1499 PROTEIN

(Listeria
monocytogenes) 		PF02618
(YceG) 		5 ILE A 103
ILE A  56
PHE A  77
LEU A  63
LEU A  87
 None
SO4  A 404 (-4.1A)
PGE  A 408 ( 4.7A)
None
None
 0.93A 4rz7A-4iiwA:
undetectable		 4rz7A-4iiwA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		5 ILE A 197
ALA A 218
LYS A 220
PHE A 269
LEU A 273
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
29X  A 702 (-3.6A)
None
29X  A 702 (-4.6A)
 0.52A 4rz7A-4mk0A:
25.4		 4rz7A-4mk0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		5 ILE A 197
ALA A 218
PHE A 269
LEU A 273
LEU A 324
 29X  A 702 (-4.7A)
29X  A 702 (-3.1A)
None
29X  A 702 (-4.6A)
29X  A 702 (-4.6A)
 0.60A 4rz7A-4mk0A:
25.4		 4rz7A-4mk0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE A 369
ALA A 388
LYS A 390
LEU A 434
LEU A 489
 None
 0.88A 4rz7A-4o1oA:
15.2		 4rz7A-4o1oA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  67
LYS A  69
THR A 123
LEU A 125
LEU A 180
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 ( 4.5A)
 0.55A 4rz7A-4o38A:
22.0		 4rz7A-4o38A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ILE B 371
ALA B 390
LYS B 392
LEU B 436
LEU B 492
 ACP  B 801 (-4.2A)
ACP  B 801 (-3.2A)
ACP  B 801 (-2.8A)
ACP  B 801 ( 4.9A)
ACP  B 801 (-4.5A)
 0.72A 4rz7A-4oavB:
16.4		 4rz7A-4oavB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 ILE A  19
ALA A  40
LYS A  42
LEU A  97
VAL A  98
LEU A 148
 None
 0.63A 4rz7A-4ow8A:
9.2		 4rz7A-4ow8A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 ILE A  19
ALA A  40
THR A  65
LEU A  97
VAL A  98
LEU A 148
 None
 0.63A 4rz7A-4ow8A:
9.2		 4rz7A-4ow8A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF01636
(APH) 		5 ALA A  56
LYS A  58
THR A 108
VAL A 111
LEU A 232
 HIS  A 401 (-3.5A)
None
None
HIS  A 401 (-4.2A)
HIS  A 401 (-4.3A)
 0.91A 4rz7A-4pdyA:
8.2		 4rz7A-4pdyA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ALA A  45
LYS A  47
ILE A  79
VAL A  98
LEU A 148
 STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
 0.86A 4rz7A-4rewA:
26.9		 4rz7A-4rewA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 108
 39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
 0.83A 4rz7A-4tyhB:
17.6		 4rz7A-4tyhB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		6 ILE A 377
ALA A 385
PHE A 361
LEU A  41
VAL A  42
LEU A  27
 None
 1.43A 4rz7A-4wb0A:
undetectable		 4rz7A-4wb0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjc DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Bacillus
halodurans) 		PF00692
(dUTPase) 		5 ILE A  69
ALA A  79
ILE A 108
LEU A  77
LEU A 106
 None
 0.96A 4rz7A-4xjcA:
undetectable		 4rz7A-4xjcA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ILE A  29
ALA A  50
ILE A  82
LEU A 105
LEU A 154
 42A  A 402 ( 4.7A)
42A  A 402 (-3.2A)
None
42A  A 402 ( 4.9A)
42A  A 402 ( 4.9A)
 0.75A 4rz7A-4xrlA:
8.3		 4rz7A-4xrlA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 469
ALA A 488
LYS A 490
ILE A 522
THR A 539
LEU A 595
 4CV  A 801 (-4.3A)
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
4CV  A 801 (-4.4A)
 0.61A 4rz7A-4yffA:
13.6		 4rz7A-4yffA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ILE A  30
ALA A  51
LYS A  53
ILE A  84
LEU A 108
 ANP  A 401 (-4.9A)
ANP  A 401 (-3.5A)
ANP  A 401 (-2.9A)
None
ANP  A 401 ( 4.8A)
 0.43A 4rz7A-5awmA:
22.3		 4rz7A-5awmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ILE A  69
ALA A  90
LYS A  92
LEU A 146
LEU A 196
 None
 0.87A 4rz7A-5ci6A:
10.4		 4rz7A-5ci6A:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		10 ILE A 540
ALA A 561
LYS A 563
THR A 586
ILE A 595
PHE A 609
THR A 611
LEU A 613
VAL A 614
LEU A 664
 4ZS  A 901 (-4.2A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.4A)
4ZS  A 901 (-4.3A)
None
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.8A)
4ZS  A 901 (-3.6A)
 0.38A 4rz7A-5ezrA:
55.5		 4rz7A-5ezrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 928
LYS A 930
ILE A 960
VAL A 981
LEU A1030
 5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.6A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.4A)
 0.59A 4rz7A-5f1zA:
23.3		 4rz7A-5f1zA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE C  23
ALA C  44
LYS C  46
LEU C  92
LEU C 143
 None
 0.60A 4rz7A-5fqdC:
23.4		 4rz7A-5fqdC:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT

(Escherichia
coli) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 ALA A 123
THR C 119
THR A  80
LEU A  82
LEU A  90
 None
 0.81A 4rz7A-5g5gA:
undetectable		 4rz7A-5g5gA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ALA A  41
LYS A  43
LEU A  92
VAL A  93
LEU A 143
 ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
ADP  A 301 ( 4.8A)
ADP  A 301 (-4.0A)
ADP  A 301 (-4.7A)
 0.51A 4rz7A-5hu3A:
11.4		 4rz7A-5hu3A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		5 ALA A 356
LYS A 358
THR A 445
LEU A 447
VAL A 448
 ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
ANP  A 700 (-4.1A)
ANP  A 700 ( 4.5A)
ANP  A 700 (-3.8A)
 0.68A 4rz7A-5i35A:
7.3		 4rz7A-5i35A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ALA A  43
LYS A  45
ILE A  77
VAL A  96
LEU A 146
 STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.0A)
STU  A 601 (-4.5A)
 0.95A 4rz7A-5isoA:
11.3		 4rz7A-5isoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 396
ALA A 417
LEU A 467
VAL A 468
LEU A 518
 GUI  A 701 (-4.1A)
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.7A)
GUI  A 701 (-4.0A)
GUI  A 701 (-4.4A)
 0.57A 4rz7A-5jznA:
11.8		 4rz7A-5jznA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 639
ALA A 663
LYS A 665
ILE A 695
THR A 711
 6P6  A1001 (-4.0A)
6P6  A1001 (-3.3A)
None
None
6P6  A1001 (-3.5A)
 0.62A 4rz7A-5l6oA:
8.3		 4rz7A-5l6oA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 176
LYS A 178
ILE A 212
LEU A 230
LEU A 282
 7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
None
7A7  A 501 (-4.9A)
 0.57A 4rz7A-5lxdA:
23.8		 4rz7A-5lxdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 155
ALA A 176
LYS A 178
LEU A 230
LEU A 282
 7A7  A 501 ( 4.3A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
None
7A7  A 501 (-4.9A)
 0.74A 4rz7A-5lxdA:
23.8		 4rz7A-5lxdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 5 ILE C  15
ALA C  36
LYS C  38
LEU C  84
LEU C 135
 9XK  C 301 (-4.2A)
9XK  C 301 ( 3.7A)
9XK  C 301 ( 4.6A)
9XK  C 301 (-3.7A)
9XK  C 301 (-4.6A)
 0.45A 4rz7A-5oktC:
23.1		 4rz7A-5oktC:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ILE A 197
ALA A 218
LYS A 220
PHE A 269
LEU A 273
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
None
None
 0.57A 4rz7A-5uuuA:
12.2		 4rz7A-5uuuA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ILE A 197
ALA A 218
PHE A 269
LEU A 273
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
None
None
 0.60A 4rz7A-5uuuA:
12.2		 4rz7A-5uuuA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A  75
ALA A  96
LYS A  98
ILE A 210
LEU A 144
 None
GOL  A 401 ( 3.8A)
GOL  A 402 (-3.2A)
GOL  A 402 ( 4.0A)
GOL  A 401 (-4.3A)
 1.00A 4rz7A-5x18A:
7.6		 4rz7A-5x18A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ILE A  75
ALA A  96
LYS A  98
LEU A 144
LEU A 195
 None
GOL  A 401 ( 3.8A)
GOL  A 402 (-3.2A)
GOL  A 401 (-4.3A)
None
 0.74A 4rz7A-5x18A:
7.6		 4rz7A-5x18A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 6 ILE A 215
ALA A 236
LYS A 238
ILE A 272
LEU A 290
LEU A 342
 None
HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
HRM  A 601 ( 4.8A)
HRM  A 601 (-4.6A)
None
 0.44A 4rz7A-5y86A:
8.8		 4rz7A-5y86A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 6 ALA A  40
LYS A  42
THR A  65
LEU A  97
VAL A  98
LEU A 148
 CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.5A)
 0.52A 4rz7A-6b2qA:
9.9		 4rz7A-6b2qA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A  19
ALA A  40
LEU A  97
VAL A  98
LEU A 148
 CJJ  A 301 (-4.1A)
CJJ  A 301 (-3.5A)
None
CJJ  A 301 (-3.5A)
CJJ  A 301 (-4.5A)
 0.67A 4rz7A-6b2qA:
9.9		 4rz7A-6b2qA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 5 ILE A 531
ALA A 551
LYS A 553
ILE A 586
LEU A 654
 CQ7  A 801 (-3.6A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
CQ7  A 801 ( 4.5A)
CQ7  A 801 (-4.5A)
 0.73A 4rz7A-6b4wA:
14.2		 4rz7A-6b4wA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 ILE A 171
ALA A 192
LYS A 194
LEU A 269
VAL A 270
LEU A 319
 BI9  A 501 (-4.0A)
BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
BI9  A 501 (-4.4A)
BI9  A 501 (-4.0A)
BI9  A 501 (-4.7A)
 0.65A 4rz7A-6bqlA:
11.8		 4rz7A-6bqlA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 ILE A 134
ALA A 155
LYS A 157
LEU A 232
LEU A 282
 H1N  A 501 (-4.3A)
H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
H1N  A 501 (-4.3A)
H1N  A 501 (-4.8A)
 0.60A 4rz7A-6ccfA:
12.0		 4rz7A-6ccfA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 ILE A 171
ALA A 192
LYS A 194
LEU A 269
VAL A 270
LEU A 319
 F6J  A 501 (-4.3A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.4A)
F6J  A 501 (-4.0A)
F6J  A 501 (-4.5A)
 0.69A 4rz7A-6cmjA:
28.7		 4rz7A-6cmjA:
7.10