SIMILAR PATTERNS OF AMINO ACIDS FOR 4RYA_A_MTLA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		3 GLU A  32
TYR A 274
GLU A 276
 None
 0.83A 4ryaA-1b2hA:
3.4		 4ryaA-1b2hA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpl ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE
ALPHA-1,4-GLUCAN-4-G
LUCANOHYDROLASE

(Bacillus
licheniformis;
Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 GLU B 336
TYR A  14
GLU B 376
 None
 0.84A 4ryaA-1bplB:
undetectable		 4ryaA-1bplB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		3 GLU A 264
TYR A 307
GLU A 257
 None
 0.79A 4ryaA-1c4oA:
0.9		 4ryaA-1c4oA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		3 GLU A 279
TYR A 507
GLU A 503
 CA  A 901 ( 3.8A)
None
GOL  A 900 (-3.3A)
 0.78A 4ryaA-1dl2A:
undetectable		 4ryaA-1dl2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 GLU A 336
TYR A  12
GLU A 376
 None
 0.79A 4ryaA-1e43A:
0.0		 4ryaA-1e43A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqc EXO-(B)-(1,3)-GLUCAN
ASE

(Candida
albicans) 		PF00150
(Cellulase) 		3 GLU A 292
TYR A  29
GLU A  27
 CTS  A 401 (-2.8A)
CTS  A 401 (-4.6A)
CTS  A 401 (-2.7A)
 0.65A 4ryaA-1eqcA:
0.0		 4ryaA-1eqcA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyp CHALCONE-FLAVONONE
ISOMERASE 1

(Medicago sativa) 		PF02431
(Chalcone) 		3 GLU A 174
TYR A  28
GLU A  90
 None
 0.83A 4ryaA-1eypA:
0.0		 4ryaA-1eypA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4p GLUCAN
1,3-BETA-GLUCOSIDASE
I/II

(Saccharomyces
cerevisiae) 		PF00150
(Cellulase) 		3 GLU A 334
TYR A  67
GLU A  65
 GOL  A1450 ( 4.1A)
GOL  A1450 (-4.6A)
GOL  A1450 (-2.9A)
 0.70A 4ryaA-1h4pA:
0.0		 4ryaA-1h4pA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1i MEROZOITE SURFACE
PROTEIN-1

(Plasmodium
knowlesi) 		PF12946
(EGF_MSP1_1)
PF12947
(EGF_3) 		3 GLU A  64
TYR A  27
GLU A  33
 None
 0.75A 4ryaA-1n1iA:
undetectable		 4ryaA-1n1iA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		3 GLU A 286
TYR A 325
GLU A 330
 None
None
FE  A 501 ( 2.8A)
 0.75A 4ryaA-1phzA:
undetectable		 4ryaA-1phzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgj CITRATE LYASE, BETA
SUBUNIT

(Deinococcus
radiodurans) 		PF03328
(HpcH_HpaI) 		3 GLU A 201
TYR A 232
GLU A 208
 None
 0.71A 4ryaA-1sgjA:
undetectable		 4ryaA-1sgjA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		3 GLU A 835
TYR A 864
GLU A 923
 None
 0.84A 4ryaA-1wz2A:
undetectable		 4ryaA-1wz2A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 GLU A 299
TYR A 363
GLU A 142
 GAL  A9011 (-2.7A)
None
GAL  A9011 (-2.8A)
 0.81A 4ryaA-1xc6A:
undetectable		 4ryaA-1xc6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xup GLYCEROL KINASE

(Enterococcus
casseliflavus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 GLU O 304
TYR O 136
GLU O  85
 None
None
GOL  O 500 (-3.8A)
 0.78A 4ryaA-1xupO:
undetectable		 4ryaA-1xupO:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbo HYPOTHETICAL PROTEIN
BPP1347

(Bordetella
parapertussis) 		PF02190
(LON_substr_bdg) 		3 GLU A  60
TYR A  28
GLU A  25
 None
 0.82A 4ryaA-1zboA:
undetectable		 4ryaA-1zboA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 GLU A 163
TYR A 281
GLU A 304
 None
 0.81A 4ryaA-2c4kA:
undetectable		 4ryaA-2c4kA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 GLU X 109
TYR X 485
GLU X 484
 None
 0.80A 4ryaA-2epkX:
undetectable		 4ryaA-2epkX:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 GLU A 521
TYR A 535
GLU A 536
 None
 0.73A 4ryaA-2g3nA:
undetectable		 4ryaA-2g3nA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyk BETA-1,3-GLUCANASE

(Nocardiopsis
sp. F96) 		PF00722
(Glyco_hydro_16) 		3 GLU A  14
TYR A 242
GLU A  91
 None
 0.84A 4ryaA-2hykA:
undetectable		 4ryaA-2hykA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		3 GLU A 295
TYR A 205
GLU A 282
 None
 0.76A 4ryaA-2i7gA:
undetectable		 4ryaA-2i7gA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwb METHICILLIN
RESISTANCE MECR1
PROTEIN

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		3 GLU A 509
TYR A 546
GLU A 548
 None
None
GOL  A 606 ( 4.3A)
 0.66A 4ryaA-2iwbA:
undetectable		 4ryaA-2iwbA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 GLU A 352
TYR A  13
GLU A 330
 None
 0.81A 4ryaA-2o1bA:
undetectable		 4ryaA-2o1bA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		3 GLU A  13
TYR A  71
GLU A  72
 None
 0.68A 4ryaA-2o6iA:
undetectable		 4ryaA-2o6iA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		3 GLU A  99
TYR A 103
GLU A 138
 None
 0.82A 4ryaA-2px5A:
undetectable		 4ryaA-2px5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 GLU A 488
TYR A 445
GLU A 495
 None
 0.69A 4ryaA-2r9vA:
undetectable		 4ryaA-2r9vA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		3 GLU A1271
TYR A1476
GLU A1472
 CA  A1550 ( 4.3A)
None
GOL  A1901 (-2.7A)
 0.76A 4ryaA-2ri8A:
undetectable		 4ryaA-2ri8A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rml COPPER-TRANSPORTING
P-TYPE ATPASE COPA

(Bacillus
subtilis) 		PF00403
(HMA) 		3 GLU A 144
TYR A 118
GLU A  74
 None
 0.82A 4ryaA-2rmlA:
undetectable		 4ryaA-2rmlA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		3 GLU A 332
TYR A 371
GLU A 376
 HBI  A 500 (-3.2A)
MTY  A 300 (-3.9A)
FE  A 501 (-2.1A)
 0.82A 4ryaA-2tohA:
undetectable		 4ryaA-2tohA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v28 PHENYLALANINE-4-HYDR
OXYLASE

(Colwellia
psychrerythraea) 		PF00351
(Biopterin_H) 		3 GLU A 123
TYR A 162
GLU A 167
 None
 0.69A 4ryaA-2v28A:
undetectable		 4ryaA-2v28A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl7 XPD

(Sulfurisphaera
tokodaii) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		3 GLU A 476
TYR A 295
GLU A 246
 None
 0.59A 4ryaA-2vl7A:
undetectable		 4ryaA-2vl7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		3 GLU A  53
TYR A 292
GLU A 138
 None
 0.82A 4ryaA-2vy0A:
undetectable		 4ryaA-2vy0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		3 GLU A 274
TYR A 106
GLU A 281
 None
 0.72A 4ryaA-3a3cA:
32.5		 4ryaA-3a3cA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		3 GLU A 271
TYR A 399
GLU A 249
 None
 0.71A 4ryaA-3aeuA:
undetectable		 4ryaA-3aeuA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
kodakarensis) 		PF05916
(Sld5) 		3 GLU B  61
TYR B  75
GLU B 146
 None
 0.80A 4ryaA-3anwB:
undetectable		 4ryaA-3anwB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1

(Saccharomyces
cerevisiae) 		PF03556
(Cullin_binding)
PF14555
(UBA_4) 		3 GLU A  80
TYR A  50
GLU A  54
 None
 0.84A 4ryaA-3bq3A:
undetectable		 4ryaA-3bq3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvw RE11660P

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 GLU A 255
TYR A 442
GLU A 360
 None
 0.79A 4ryaA-3cvwA:
undetectable		 4ryaA-3cvwA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		3 GLU A 302
TYR A 157
GLU A  24
 None
 0.78A 4ryaA-3edyA:
0.7		 4ryaA-3edyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqe PUTATIVE CYSTEIN
DIOXYGENASE

(Bacillus
subtilis) 		PF05995
(CDO_I) 		3 GLU A  71
TYR A  96
GLU A 153
 None
 0.76A 4ryaA-3eqeA:
undetectable		 4ryaA-3eqeA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		3 GLU A 412
TYR A 563
GLU A 600
 None
 0.69A 4ryaA-3fhaA:
undetectable		 4ryaA-3fhaA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 GLU A 477
TYR A 385
GLU A 381
 None
None
PO4  A 504 (-2.7A)
 0.82A 4ryaA-3g25A:
undetectable		 4ryaA-3g25A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 GLU A 505
TYR A 516
GLU A  17
 None
 0.74A 4ryaA-3gyxA:
undetectable		 4ryaA-3gyxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i99 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Vibrio cholerae) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		3 GLU A  85
TYR A 149
GLU A 151
 None
 0.83A 4ryaA-3i99A:
undetectable		 4ryaA-3i99A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iln LAMINARINASE

(Rhodothermus
marinus) 		PF00722
(Glyco_hydro_16) 		3 GLU A  18
TYR A 253
GLU A  95
 None
 0.78A 4ryaA-3ilnA:
undetectable		 4ryaA-3ilnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLU A 292
TYR A 113
GLU A 304
 None
 0.59A 4ryaA-3ip3A:
undetectable		 4ryaA-3ip3A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbb PHOSPHORYLATED
CARBOHYDRATES
PHOSPHATASE TM_1254

(Thermotoga
maritima) 		PF13419
(HAD_2) 		3 GLU A 113
TYR A  19
GLU A  47
 GLU  A 113 ( 0.6A)
TYR  A  19 ( 1.3A)
GLU  A  47 (-0.6A)
 0.82A 4ryaA-3kbbA:
undetectable		 4ryaA-3kbbA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kew DHHA1 DOMAIN PROTEIN

(Clostridium
perfringens) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 GLU A  20
TYR A  60
GLU A  62
 None
 0.60A 4ryaA-3kewA:
undetectable		 4ryaA-3kewA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg6 CURF

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		3 GLU A1959
TYR A1811
GLU A1813
 None
 0.77A 4ryaA-3kg6A:
undetectable		 4ryaA-3kg6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkf PUTATIVE ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASE

(Bacteroides
thetaiotaomicron) 		PF03992
(ABM) 		3 GLU A  55
TYR A  87
GLU A  85
 ACT  A 203 (-2.4A)
None
ACT  A 203 ( 3.9A)
 0.82A 4ryaA-3kkfA:
undetectable		 4ryaA-3kkfA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 GLU A 119
TYR A  82
GLU A 241
 None
 0.73A 4ryaA-3kzuA:
undetectable		 4ryaA-3kzuA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv7 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Helicobacter
pylori) 		PF01467
(CTP_transf_like) 		3 GLU A 114
TYR A  98
GLU A  99
 None
 0.83A 4ryaA-3nv7A:
undetectable		 4ryaA-3nv7A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 GLU A 298
TYR A 362
GLU A 142
 GAL  A1024 (-2.7A)
None
GAL  A1024 (-2.8A)
 0.78A 4ryaA-3ogrA:
undetectable		 4ryaA-3ogrA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		3 GLU A 244
TYR A 300
GLU A 373
 FMT  A 382 ( 4.2A)
None
None
 0.70A 4ryaA-3pmmA:
undetectable		 4ryaA-3pmmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 GLU A  14
TYR A 413
GLU A 388
 None
 0.81A 4ryaA-3pocA:
undetectable		 4ryaA-3pocA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qac 11S GLOBULIN SEED
STORAGE PROTEIN

(Amaranthus
hypochondriacus) 		PF00190
(Cupin_1) 		3 GLU A  36
TYR A 349
GLU A  77
 None
 0.80A 4ryaA-3qacA:
undetectable		 4ryaA-3qacA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwt PUTATIVE GH105
FAMILY PROTEIN

(Salmonella
enterica) 		PF07470
(Glyco_hydro_88) 		3 GLU A 243
TYR A 299
GLU A 372
 GOL  A 381 (-2.9A)
None
None
 0.75A 4ryaA-3qwtA:
undetectable		 4ryaA-3qwtA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 GLU A  96
TYR A 307
GLU A 274
 EDO  A 413 (-4.7A)
None
None
 0.73A 4ryaA-3sf6A:
undetectable		 4ryaA-3sf6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slr UNCHARACTERIZED
PROTEIN BF1531

(Bacteroides
fragilis) 		no annotation 3 GLU A  91
TYR A 191
GLU A 195
 None
 0.80A 4ryaA-3slrA:
2.4		 4ryaA-3slrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8i PURINE NUCLEOSIDASE,
(IUNH-2)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		3 GLU A 111
TYR A  61
GLU A  99
 None
 0.78A 4ryaA-3t8iA:
0.7		 4ryaA-3t8iA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		3 GLU A 268
TYR A 331
GLU A 129
 GAL  A 900 (-2.5A)
None
GAL  A 900 (-2.8A)
 0.77A 4ryaA-3thcA:
undetectable		 4ryaA-3thcA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		3 GLU A 250
TYR A 310
GLU A 120
 EPE  A 804 (-3.8A)
None
EPE  A 804 (-3.4A)
 0.75A 4ryaA-3w5fA:
undetectable		 4ryaA-3w5fA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 GLU E 423
TYR E 397
GLU E 400
 None
 0.70A 4ryaA-4a0lE:
undetectable		 4ryaA-4a0lE:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ate BETA-PORPHYRANASE A

(Zobellia
galactanivorans) 		no annotation 3 GLU A  38
TYR A 270
GLU A 116
 None
 0.64A 4ryaA-4ateA:
undetectable		 4ryaA-4ateA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		3 GLU A 253
TYR A 431
GLU A 427
 CA  A 501 (-3.4A)
None
IFL  A 503 (-2.9A)
 0.75A 4ryaA-4ayrA:
undetectable		 4ryaA-4ayrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		3 GLU A 238
TYR A 303
GLU A  98
 None
 0.84A 4ryaA-4e8dA:
undetectable		 4ryaA-4e8dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		3 GLU A1191
TYR A1311
GLU A1309
 None
 0.59A 4ryaA-4guaA:
undetectable		 4ryaA-4guaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzv HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14869
(DUF4488) 		3 GLU A 146
TYR A  95
GLU A  97
 UNL  A 200 ( 3.0A)
None
UNL  A 200 ( 2.8A)
 0.69A 4ryaA-4gzvA:
undetectable		 4ryaA-4gzvA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans) 		PF11701
(UNC45-central) 		3 GLU A 355
TYR A 549
GLU A 462
 None
 0.74A 4ryaA-4i2wA:
undetectable		 4ryaA-4i2wA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i95 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF14869
(DUF4488) 		3 GLU A 146
TYR A  95
GLU A  97
 UNL  A 200 ( 2.9A)
None
UNL  A 200 ( 2.9A)
 0.65A 4ryaA-4i95A:
undetectable		 4ryaA-4i95A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iab HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF14869
(DUF4488) 		3 GLU A 146
TYR A  95
GLU A  97
 UNL  A 201 ( 2.9A)
None
UNL  A 201 ( 2.9A)
 0.67A 4ryaA-4iabA:
undetectable		 4ryaA-4iabA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 GLU A  99
TYR A 103
GLU A 138
 None
 0.79A 4ryaA-4k6mA:
undetectable		 4ryaA-4k6mA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr4 HYPOTHETICAL PROTEIN

([Eubacterium]
rectale) 		no annotation 3 GLU A 159
TYR A  82
GLU A 293
 None
 0.84A 4ryaA-4lr4A:
undetectable		 4ryaA-4lr4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzi MULTICYSTATIN

(Solanum
tuberosum) 		PF00031
(Cystatin) 		3 GLU A 267
TYR A 244
GLU A 206
 None
 0.72A 4ryaA-4lziA:
undetectable		 4ryaA-4lziA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		3 GLU A 233
TYR A 299
GLU A  98
 None
None
PG0  A 900 (-3.2A)
 0.82A 4ryaA-4madA:
undetectable		 4ryaA-4madA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me4 METAL DEPENDENT
PHOSPHOHYDROLASE

(Persephonella
marina) 		PF01590
(GAF)
PF01966
(HD) 		3 GLU A 198
TYR A 173
GLU A 169
 None
 0.81A 4ryaA-4me4A:
undetectable		 4ryaA-4me4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqe MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS
I-RELATED GENE
PROTEIN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 GLU A 149
TYR A 112
GLU A  76
 None
 0.56A 4ryaA-4nqeA:
undetectable		 4ryaA-4nqeA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		3 GLU A 336
TYR A 267
GLU A 269
 None
 0.76A 4ryaA-4nz6A:
undetectable		 4ryaA-4nz6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ols ENDOLYSIN

(Staphylococcus
virus G15) 		PF01510
(Amidase_2) 		3 GLU A 311
TYR A 244
GLU A 253
 None
 0.71A 4ryaA-4olsA:
undetectable		 4ryaA-4olsA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		3 GLU A  78
TYR A 243
GLU A 242
 None
 0.80A 4ryaA-4p58A:
undetectable		 4ryaA-4p58A:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		3 GLU A  61
TYR A 135
GLU A 137
 MTL  A 501 (-2.8A)
MTL  A 501 (-4.5A)
MTL  A 501 (-3.0A)
 0.02A 4ryaA-4ryaA:
74.9		 4ryaA-4ryaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v06 TRYPTOPHAN
5-HYDROXYLASE 2

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 GLU A 319
TYR A 358
GLU A 363
 IMD  A 600 (-3.3A)
None
FE  A1491 ( 2.0A)
 0.83A 4ryaA-4v06A:
undetectable		 4ryaA-4v06A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN
PUTATIVE SAC3 FAMILY
PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7)
no annotation 		3 GLU B1129
TYR A  45
GLU A  46
 None
 0.82A 4ryaA-4wpxB:
undetectable		 4ryaA-4wpxB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yiv APICAL MEMBRANE
ANTIGEN AMA1

(Toxoplasma
gondii) 		PF02430
(AMA-1) 		3 GLU A 125
TYR A  96
GLU A 330
 None
 0.80A 4ryaA-4yivA:
undetectable		 4ryaA-4yivA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm2 TRNA
METHYLTRANSFERASE

(Yarrowia
lipolytica) 		PF08241
(Methyltransf_11) 		3 GLU Z 219
TYR Z  70
GLU Z  48
 None
 0.60A 4ryaA-5cm2Z:
undetectable		 4ryaA-5cm2Z:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		3 GLU A 871
TYR A 867
GLU A 549
 None
 0.75A 4ryaA-5ikzA:
undetectable		 4ryaA-5ikzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isu LMO0135 PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		3 GLU A 265
TYR A 320
GLU A 319
 None
 0.62A 4ryaA-5isuA:
3.4		 4ryaA-5isuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 GLU A  99
TYR A 103
GLU A 138
 None
 0.82A 4ryaA-5jjrA:
undetectable		 4ryaA-5jjrA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8f ACETYL-COENZYME A
SYNTHETASE

(Cryptococcus
neoformans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 GLU A  73
TYR A 316
GLU A  54
 None
 0.77A 4ryaA-5k8fA:
undetectable		 4ryaA-5k8fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA

(Mus musculus) 		PF01532
(Glyco_hydro_47) 		3 GLU A 419
TYR A 615
GLU A 611
 LA  A 711 ( 4.4A)
None
MAN  A 709 ( 2.8A)
 0.79A 4ryaA-5kkbA:
undetectable		 4ryaA-5kkbA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1

(Sorangium
cellulosum) 		PF00067
(p450) 		3 GLU A 203
TYR A 281
GLU A 282
 None
 0.74A 4ryaA-5livA:
undetectable		 4ryaA-5livA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		3 GLU A 347
TYR A 443
GLU A 440
 None
 0.83A 4ryaA-5mfaA:
undetectable		 4ryaA-5mfaA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx4 PENTALENENE SYNTHASE

(Streptomyces
clavuligerus) 		no annotation 3 GLU A 142
TYR A 288
GLU A 186
 None
 0.80A 4ryaA-5nx4A:
undetectable		 4ryaA-5nx4A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtk CRISPR-ASSOCIATED
ENDORIBONUCLEASE
C2C2

(Leptotrichia
shahii) 		no annotation 3 GLU A 346
TYR A 479
GLU A 426
 None
 0.81A 4ryaA-5wtkA:
undetectable		 4ryaA-5wtkA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 3 GLU A 315
TYR A 261
GLU A 257
 None
 0.59A 4ryaA-5wzkA:
undetectable		 4ryaA-5wzkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		3 GLU A1253
TYR A1242
GLU A1260
 None
 0.81A 4ryaA-5xblA:
undetectable		 4ryaA-5xblA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 3 GLU A 347
TYR A 443
GLU A 440
 None
 0.82A 4ryaA-6azpA:
undetectable		 4ryaA-6azpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 3 GLU A  56
TYR A  79
GLU A  81
 None
 0.82A 4ryaA-6b2qA:
undetectable		 4ryaA-6b2qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br8 PROTEIN A6 HOMOLOG

(Fowlpox virus) 		no annotation 3 GLU A 368
TYR A 330
GLU A 331
 None
PGV  A 404 (-3.6A)
PGV  A 404 (-4.2A)
 0.70A 4ryaA-6br8A:
undetectable		 4ryaA-6br8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		3 GLU L 143
TYR J  50
GLU J 137
 None
 0.70A 4ryaA-6cfwL:
undetectable		 4ryaA-6cfwL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 GLU A 259
TYR A 323
GLU A 123
 GLA  A 801 (-2.7A)
None
GLA  A 801 (-2.8A)
 0.70A 4ryaA-6eonA:
undetectable		 4ryaA-6eonA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 GLU A 363
TYR A 303
GLU A 305
 None
 0.83A 4ryaA-6eotA:
undetectable		 4ryaA-6eotA:
undetectable