SIMILAR PATTERNS OF AMINO ACIDS FOR 4RXD_A_RISA1404_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE


(Gallus gallus)
PF00348
(polyprenyl_synt)
5 LEU A 114
ARG A 126
GLN A 185
LYS A 214
THR A 215
None
1.00A 4rxdA-1fpsA:
38.3
4rxdA-1fpsA:
38.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fps FARNESYL DIPHOSPHATE
SYNTHASE


(Gallus gallus)
PF00348
(polyprenyl_synt)
5 LEU A 114
ASP A 117
ARG A 126
GLN A 185
THR A 215
None
0.82A 4rxdA-1fpsA:
38.3
4rxdA-1fpsA:
38.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
10 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
GLN A 241
ASP A 244
LYS A 258
None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
RIS  A 901 ( 3.6A)
MG  A 908 ( 2.7A)
RIS  A 901 (-2.7A)
0.29A 4rxdA-1rqjA:
30.1
4rxdA-1rqjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  82
ARG A  93
GLN A 154
THR A 178
None
1.20A 4rxdA-1rtrA:
24.2
4rxdA-1rtrA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  88
ARG A  93
GLN A 154
THR A 178
None
0.79A 4rxdA-1rtrA:
24.2
4rxdA-1rtrA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  88
ARG A  93
THR A 178
GLN A 215
None
0.88A 4rxdA-1rtrA:
24.2
4rxdA-1rtrA:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE


(Thermus
thermophilus)
PF00348
(polyprenyl_synt)
6 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
None
1.37A 4rxdA-1wmwA:
32.0
4rxdA-1wmwA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Pyrococcus
horikoshii)
PF00348
(polyprenyl_synt)
5 LEU A  83
ASP A  90
ARG A  95
LYS A 177
THR A 178
None
0.84A 4rxdA-1wy0A:
28.6
4rxdA-1wy0A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Pyrococcus
horikoshii)
PF00348
(polyprenyl_synt)
5 LEU A  83
ASP A  90
ARG A  95
THR A 178
GLN A 215
None
0.65A 4rxdA-1wy0A:
28.6
4rxdA-1wy0A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
6 ASP A  85
ARG A  90
LYS A 160
THR A 161
GLN A 197
ASP A 200
None
1.35A 4rxdA-2azkA:
23.0
4rxdA-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
5 LEU A  78
ASP A  81
ARG A  90
THR A 161
GLN A 197
None
0.93A 4rxdA-2azkA:
23.0
4rxdA-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Sulfolobus
solfataricus)
PF00348
(polyprenyl_synt)
6 LEU A  78
ASP A  85
ARG A  90
THR A 161
GLN A 197
ASP A 200
None
0.83A 4rxdA-2azkA:
23.0
4rxdA-2azkA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae)
PF00348
(polyprenyl_synt)
9 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
GLN A 211
ASP A 214
None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
None
None
0.63A 4rxdA-2dh4A:
9.0
4rxdA-2dh4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE


(Thermotoga
maritima)
PF00348
(polyprenyl_synt)
5 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
0.81A 4rxdA-2ftzA:
23.7
4rxdA-2ftzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE


(Thermotoga
maritima)
PF00348
(polyprenyl_synt)
5 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
MLY  A 163 ( 3.8A)
0.51A 4rxdA-2ftzA:
23.7
4rxdA-2ftzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE


(Agrobacterium
fabrum)
PF00348
(polyprenyl_synt)
5 ASP A 125
ARG A 136
GLN A 198
LYS A 221
THR A 222
None
1.48A 4rxdA-2h8oA:
24.1
4rxdA-2h8oA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE


(Agrobacterium
fabrum)
PF00348
(polyprenyl_synt)
5 LEU A 122
ASP A 125
ARG A 136
GLN A 198
THR A 222
None
1.16A 4rxdA-2h8oA:
24.1
4rxdA-2h8oA:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE


(Cryptosporidium
parvum)
PF00348
(polyprenyl_synt)
8 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
GLN A 251
None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
RIS  A 400 (-3.1A)
0.40A 4rxdA-2o1oA:
36.6
4rxdA-2o1oA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE


(Cryptosporidium
parvum)
PF00348
(polyprenyl_synt)
5 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
1.18A 4rxdA-2o1oA:
36.6
4rxdA-2o1oA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
6 LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.20A 4rxdA-2q80A:
25.7
4rxdA-2q80A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
8 LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.65A 4rxdA-2q80A:
25.7
4rxdA-2q80A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
6 LEU A  61
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.82A 4rxdA-2q80A:
25.7
4rxdA-2q80A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE


(Arabidopsis
thaliana)
PF00348
(polyprenyl_synt)
6 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
0.67A 4rxdA-3aq0A:
24.5
4rxdA-3aq0A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE


(Micrococcus
luteus)
PF00348
(polyprenyl_synt)
8 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
1.01A 4rxdA-3aqcB:
27.7
4rxdA-3aqcB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE


(Legionella
pneumophila)
PF00348
(polyprenyl_synt)
5 LEU A  91
ARG A 105
GLN A 168
THR A 193
GLN A 231
None
0.96A 4rxdA-3lomA:
24.5
4rxdA-3lomA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE


(Legionella
pneumophila)
PF00348
(polyprenyl_synt)
5 LEU A  91
ASP A 100
ARG A 105
THR A 193
GLN A 231
None
0.85A 4rxdA-3lomA:
24.5
4rxdA-3lomA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE


(Rhodobacter
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  78
ASP A  81
GLN A 153
LYS A 178
THR A 179
None
1.40A 4rxdA-3m0gA:
23.6
4rxdA-3m0gA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE


(Rhodobacter
capsulatus)
PF00348
(polyprenyl_synt)
6 LEU A  78
ASP A  87
ARG A  92
GLN A 153
LYS A 178
THR A 179
None
0.88A 4rxdA-3m0gA:
23.6
4rxdA-3m0gA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
5 LEU A  86
ARG A 100
THR A 184
GLN A 221
ASP A 224
GOL  A 310 ( 4.3A)
None
None
None
None
0.91A 4rxdA-3m9uA:
24.1
4rxdA-3m9uA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE


(Rhodobacter
capsulatus)
PF00348
(polyprenyl_synt)
6 LEU A  90
ASP A  93
ARG A 102
LYS A 179
THR A 180
GLN A 217
None
0.83A 4rxdA-3mzvA:
24.9
4rxdA-3mzvA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE


(Campylobacter
jejuni)
PF00348
(polyprenyl_synt)
6 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
None
1.32A 4rxdA-3npkA:
25.3
4rxdA-3npkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE


(Campylobacter
jejuni)
PF00348
(polyprenyl_synt)
6 LEU A  75
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
None
0.95A 4rxdA-3npkA:
25.3
4rxdA-3npkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE


(Pseudomonas
protegens)
PF00348
(polyprenyl_synt)
5 LEU A  80
ARG A  94
LYS A 180
THR A 181
GLN A 219
None
DMA  A 300 (-2.9A)
POP  A 301 ( 2.4A)
None
POP  A 301 ( 4.5A)
0.96A 4rxdA-3p41A:
23.8
4rxdA-3p41A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE


(Pseudomonas
protegens)
PF00348
(polyprenyl_synt)
7 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
THR A 181
None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
0.49A 4rxdA-3p41A:
23.8
4rxdA-3p41A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE


(Enterococcus
faecalis)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  82
ARG A  93
GLN A 153
THR A 177
None
1.23A 4rxdA-3p8lA:
24.4
4rxdA-3p8lA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE


(Enterococcus
faecalis)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  88
ARG A  93
GLN A 153
THR A 177
None
0.75A 4rxdA-3p8lA:
24.4
4rxdA-3p8lA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
5 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.88A 4rxdA-3pkoA:
24.7
4rxdA-3pkoA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
5 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
None
None
CIT  A 326 ( 4.8A)
None
None
0.89A 4rxdA-3pkoA:
24.7
4rxdA-3pkoA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
5 ASP A  98
ARG A 103
GLN A 225
ASP A 228
LYS A 242
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
DMA  A 501 (-2.7A)
1.22A 4rxdA-3q1oA:
29.4
4rxdA-3q1oA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
10 LEU A  89
ASP A  92
ASP A  98
ARG A 103
GLN A 163
LYS A 186
THR A 187
GLN A 225
ASP A 228
LYS A 242
DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
DMA  A 501 (-3.1A)
DMA  A 500 (-3.4A)
DMA  A 501 ( 3.8A)
DMA  A 501 ( 3.5A)
DMA  A 501 (-2.7A)
0.50A 4rxdA-3q1oA:
29.4
4rxdA-3q1oA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Corynebacterium
glutamicum)
PF00348
(polyprenyl_synt)
6 LEU A 105
ASP A 108
ARG A 117
GLN A 191
LYS A 215
LYS A 271
None
MG  A 381 (-2.4A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-3.0A)
DMA  A 384 ( 2.8A)
1.29A 4rxdA-3qqvA:
33.4
4rxdA-3qqvA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Corynebacterium
glutamicum)
PF00348
(polyprenyl_synt)
6 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 191
LYS A 215
None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-3.0A)
0.78A 4rxdA-3qqvA:
33.4
4rxdA-3qqvA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Corynebacterium
glutamicum)
PF00348
(polyprenyl_synt)
7 LEU A 105
ASP A 108
ASP A 112
ARG A 117
LYS A 215
THR A 216
GLN A 254
None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
DMA  A 383 (-3.2A)
0.59A 4rxdA-3qqvA:
33.4
4rxdA-3qqvA:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
5 LEU A  74
ASP A  77
LYS A 162
THR A 163
GLN A 197
None
0.75A 4rxdA-3tc1A:
24.7
4rxdA-3tc1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
5 LEU A  74
LYS A 162
THR A 163
GLN A 197
ASP A 200
None
None
None
None
MG  A 500 (-2.9A)
0.45A 4rxdA-3tc1A:
24.7
4rxdA-3tc1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE


(Methylococcus
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  88
ARG A  99
GLN A 162
THR A 186
None
1.36A 4rxdA-3ts7A:
7.4
4rxdA-3ts7A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE


(Methylococcus
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  88
ARG A  99
LYS A 185
THR A 186
None
0.98A 4rxdA-3ts7A:
7.4
4rxdA-3ts7A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE


(Methylococcus
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  94
ARG A  99
GLN A 162
THR A 186
None
0.90A 4rxdA-3ts7A:
7.4
4rxdA-3ts7A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE


(Methylococcus
capsulatus)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  94
ARG A  99
LYS A 185
THR A 186
None
0.70A 4rxdA-3ts7A:
7.4
4rxdA-3ts7A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
6 LEU A  81
ARG A  93
LYS A 170
THR A 171
GLN A 208
ASP A 211
None
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
IPE  A 402 ( 4.6A)
0.91A 4rxdA-3wjoA:
24.5
4rxdA-3wjoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
6 LEU A  81
ASP A  84
ARG A  93
LYS A 170
THR A 171
GLN A 208
None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 ( 3.8A)
IPE  A 402 (-3.6A)
0.89A 4rxdA-3wjoA:
24.5
4rxdA-3wjoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
5 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
0.49A 4rxdA-3wjoA:
24.5
4rxdA-3wjoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE


(Pseudomonas
aeruginosa)
PF00348
(polyprenyl_synt)
6 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
0.71A 4rxdA-3zouA:
7.2
4rxdA-3zouA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE


(Pseudomonas
aeruginosa)
PF00348
(polyprenyl_synt)
6 LEU A  80
ASP A  83
ASP A  89
ARG A  94
LYS A 180
THR A 181
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.0A)
None
0.52A 4rxdA-3zouA:
7.2
4rxdA-3zouA:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
cruzi)
PF00348
(polyprenyl_synt)
10 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
0MW  A 404 ( 3.8A)
MG  A 401 (-2.7A)
0MW  A 404 ( 3.0A)
0.45A 4rxdA-4e1eA:
53.3
4rxdA-4e1eA:
69.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE


(Marinomonas sp.
MED121)
PF00348
(polyprenyl_synt)
5 LEU A  80
ASP A  83
ASP A  89
LYS A 178
THR A 179
None
0.78A 4rxdA-4f62A:
10.6
4rxdA-4f62A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE


(Marinomonas sp.
MED121)
PF00348
(polyprenyl_synt)
5 LEU A  80
ASP A  83
GLN A 155
LYS A 178
THR A 179
None
0.98A 4rxdA-4f62A:
10.6
4rxdA-4f62A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
6 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
GLN A 199
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
None
1.13A 4rxdA-4fp4A:
20.1
4rxdA-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
6 ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
GLN A 199
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
None
1.14A 4rxdA-4fp4A:
20.1
4rxdA-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
6 LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
1.04A 4rxdA-4fp4A:
20.1
4rxdA-4fp4A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
5 LEU A  82
ASP A  85
ARG A  94
LYS A 184
THR A 185
None
0.82A 4rxdA-4gp1A:
27.5
4rxdA-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
5 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
None
0.82A 4rxdA-4gp1A:
27.5
4rxdA-4gp1A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE


(Pseudoalteromonas
atlantica)
PF00348
(polyprenyl_synt)
5 LEU A  81
ASP A  84
LYS A 170
THR A 171
GLN A 208
None
0.93A 4rxdA-4jxyA:
24.1
4rxdA-4jxyA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE


(Pseudoalteromonas
atlantica)
PF00348
(polyprenyl_synt)
5 LEU A  81
LYS A 170
THR A 171
GLN A 208
ASP A 211
None
0.85A 4rxdA-4jxyA:
24.1
4rxdA-4jxyA:
26.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE


(Leishmania
major)
PF00348
(polyprenyl_synt)
9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
ASP A 250
LYS A 264
None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
0.67A 4rxdA-4jzxA:
54.0
4rxdA-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE


(Leishmania
major)
PF00348
(polyprenyl_synt)
9 LEU A  95
ASP A  98
ASP A 102
ARG A 107
LYS A 207
THR A 208
GLN A 247
ASP A 250
LYS A 264
None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
IPE  A 401 (-3.7A)
CA  A 404 (-3.0A)
476  A 402 (-2.9A)
0.45A 4rxdA-4jzxA:
54.0
4rxdA-4jzxA:
58.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA


(Artemisia
spiciformis)
PF00348
(polyprenyl_synt)
5 LEU A  94
ASP A  97
ARG A 106
GLN A 165
THR A 195
None
0.70A 4rxdA-4kk2A:
40.4
4rxdA-4kk2A:
43.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA


(Artemisia
spiciformis)
PF00348
(polyprenyl_synt)
5 LEU A  94
ASP A  97
ARG A 106
LYS A 194
THR A 195
None
0.90A 4rxdA-4kk2A:
40.4
4rxdA-4kk2A:
43.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE


(Zymomonas
mobilis)
PF00348
(polyprenyl_synt)
6 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 159
THR A 185
None
0.60A 4rxdA-4kkmA:
13.5
4rxdA-4kkmA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE


(Zymomonas
mobilis)
PF00348
(polyprenyl_synt)
5 LEU A  83
ASP A  92
ARG A  97
LYS A 184
THR A 185
None
1.06A 4rxdA-4kkmA:
13.5
4rxdA-4kkmA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE


(Streptococcus
uberis)
PF00348
(polyprenyl_synt)
7 LEU A  75
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
ASP A 213
IPE  A 301 (-4.7A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
None
0.90A 4rxdA-4lfeA:
25.0
4rxdA-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE


(Streptococcus
uberis)
PF00348
(polyprenyl_synt)
7 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
GLN A 210
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
None
0.70A 4rxdA-4lfeA:
25.0
4rxdA-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE


(Streptococcus
uberis)
PF00348
(polyprenyl_synt)
7 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
0.51A 4rxdA-4lfeA:
25.0
4rxdA-4lfeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE


(Roseobacter
denitrificans)
PF00348
(polyprenyl_synt)
7 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
ASP A 216
LYS A 230
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
0.75A 4rxdA-4llsA:
27.7
4rxdA-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE


(Roseobacter
denitrificans)
PF00348
(polyprenyl_synt)
9 LEU A  77
ASP A  80
ASP A  86
ARG A  91
LYS A 178
THR A 179
GLN A 213
ASP A 216
LYS A 230
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
IPE  A 301 ( 4.1A)
CA  A 303 (-2.9A)
GST  A 302 (-2.7A)
0.69A 4rxdA-4llsA:
27.7
4rxdA-4llsA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE


(Acinetobacter
baumannii)
PF00348
(polyprenyl_synt)
5 LEU A  85
ASP A  88
LYS A 174
THR A 175
GLN A 211
None
0.87A 4rxdA-4lobA:
25.7
4rxdA-4lobA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE


(Acinetobacter
baumannii)
PF00348
(polyprenyl_synt)
5 LEU A  85
LYS A 174
THR A 175
GLN A 211
ASP A 214
None
0.84A 4rxdA-4lobA:
25.7
4rxdA-4lobA:
27.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
10 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.26A 4rxdA-4p0vA:
44.9
4rxdA-4p0vA:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
9 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
GLN A 252
ASP A 255
LYS A 269
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
3YQ  A3001 ( 4.2A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
0.66A 4rxdA-4rxeA:
54.8
4rxdA-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
8 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
ASP A 255
LYS A 269
3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
MG  A3003 ( 2.9A)
3YQ  A3001 (-3.1A)
0.81A 4rxdA-4rxeA:
54.8
4rxdA-4rxeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
5 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
1.17A 4rxdA-4rxeA:
54.8
4rxdA-4rxeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE


(Thermotoga
neapolitana)
PF00348
(polyprenyl_synt)
5 LEU A  71
ASP A  74
ARG A  85
THR A 164
GLN A 198
None
0.95A 4rxdA-4wk5A:
23.7
4rxdA-4wk5A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE


(Thermotoga
neapolitana)
PF00348
(polyprenyl_synt)
6 LEU A  71
ASP A  80
ARG A  85
THR A 164
GLN A 198
ASP A 201
None
0.73A 4rxdA-4wk5A:
23.7
4rxdA-4wk5A:
27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
5 ASP B 107
ARG B 112
GLN B 252
ASP B 255
LYS B 269
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
1.20A 4rxdA-5ahuB:
41.7
4rxdA-5ahuB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
10 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
GLN B 252
ASP B 255
LYS B 269
None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
G76  B1368 ( 4.0A)
MG  B1371 ( 3.0A)
G76  B1368 (-3.1A)
0.48A 4rxdA-5ahuB:
41.7
4rxdA-5ahuB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE


(Geobacillus
stearothermophilus)
PF00348
(polyprenyl_synt)
7 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 160
LYS A 183
THR A 184
None
0.82A 4rxdA-5aypA:
22.9
4rxdA-5aypA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00348
(polyprenyl_synt)
5 LEU A  88
ASP A  91
ASP A  97
ARG A 102
GLN A 166
None
0.97A 4rxdA-5e8lA:
23.2
4rxdA-5e8lA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
6 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
GLN A 206
PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
None
0.96A 4rxdA-5h9dA:
28.0
4rxdA-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
5 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
0.83A 4rxdA-5h9dA:
28.0
4rxdA-5h9dA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE


(Staphylococcus
aureus)
PF00348
(polyprenyl_synt)
5 LEU A  79
LYS A 168
THR A 169
GLN A 206
ASP A 209
PO4  A 501 (-4.5A)
None
None
None
None
0.94A 4rxdA-5h9dA:
28.0
4rxdA-5h9dA:
26.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE


(Plasmodium
vivax)
PF00348
(polyprenyl_synt)
9 ASP A 126
ASP A 130
ARG A 135
GLN A 195
LYS A 243
THR A 244
GLN A 284
ASP A 287
LYS A 301
04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-3.3A)
04M  A 401 (-4.5A)
04M  A 401 ( 3.8A)
None
None
04M  A 401 ( 3.9A)
0.76A 4rxdA-5hn7A:
42.8
4rxdA-5hn7A:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa)
PF00348
(polyprenyl_synt)
5 LEU A  82
ASP A  85
ASP A  91
THR A 191
GLN A 228
None
1.06A 4rxdA-5xn6A:
23.9
4rxdA-5xn6A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE


(Choristoneura
fumiferana)
no annotation 9 ASP A 147
ASP A 151
ARG A 156
GLN A 215
LYS A 244
THR A 245
GLN A 284
ASP A 287
LYS A 301
MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.6A)
C6M  A 401 (-3.7A)
MG  A 404 ( 2.7A)
C6M  A 401 (-2.9A)
0.29A 4rxdA-6b07A:
43.1
4rxdA-6b07A:
12.54