SIMILAR PATTERNS OF AMINO ACIDS FOR 4RVJ_B_478B101_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1czi	CHYMOSIN (Bos taurus)	PF00026 (Asp)	5	ASP E 215 GLY E 217 VAL E 222 GLY E 76 ILE E 300	None	0.77A	4rvjB-1cziE: 6.6	4rvjB-1cziE: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1czi	CHYMOSIN (Bos taurus)	PF00026 (Asp)	5	LEU E 30 ASP E 32 GLY E 34 ASP E 37 ILE E 120	None	0.58A	4rvjB-1cziE: 6.6	4rvjB-1cziE: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1deu	PROCATHEPSIN X (Homo sapiens)	PF00112 (Peptidase_C1)	6	LEU A 57 GLY A 87 ALA A 83 ASP A 81 GLY A 130 ILE A 241	None	1.26A	4rvjB-1deuA: undetectable	4rvjB-1deuA: 16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ef7	CATHEPSIN X (Homo sapiens)	PF00112 (Peptidase_C1)	6	LEU A 57 GLY A 87 ALA A 83 ASP A 81 GLY A 130 ILE A 241	None	1.28A	4rvjB-1ef7A: undetectable	4rvjB-1ef7A: 19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ek6	UDP-GALACTOSE 4-EPIMERASE (Homo sapiens)	PF16363 (GDP_Man_Dehyd)	5	LEU A 68 GLY A 90 ALA A 89 ILE A 164 ILE A 67	None NAI A 400 (-4.1A) NAI A 400 (-3.7A) None NAI A 400 (-3.8A)	0.79A	4rvjB-1ek6A: undetectable	4rvjB-1ek6A: 14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1gpe	PROTEIN (GLUCOSE OXIDASE) (Penicillium amagasakiense)	PF00732 (GMC_oxred_N) PF05199 (GMC_oxred_C)	6	LEU A 302 GLY A 294 ALA A 293 VAL A 254 ILE A 551 ILE A 301	None FAD A 600 ( 3.8A) FAD A 600 (-3.6A) FAD A 600 (-4.0A) None None	1.33A	4rvjB-1gpeA: undetectable	4rvjB-1gpeA: 9.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ALA A 28 ASP A 30 VAL A 32 GLY A 48 ILE A 84	A79 A 800 (-3.1A) A79 A 800 ( 4.9A) A79 A 800 ( 4.4A) A79 A 800 (-3.6A) A79 A 800 (-3.6A)	0.84A	4rvjB-1hvcA: 13.8	4rvjB-1hvcA: 43.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ALA A 28 ASP A 30 VAL A 32 GLY A 48 ILE A 84	A79 A 800 ( 4.0A) A79 A 800 (-3.2A) A79 A 800 ( 4.7A) A79 A 800 ( 4.3A) A79 A 800 (-4.1A) A79 A 800 (-3.8A)	0.95A	4rvjB-1hvcA: 13.8	4rvjB-1hvcA: 43.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	A79 A 800 ( 3.8A) A79 A 800 (-2.7A) A79 A 800 (-3.1A) A79 A 800 (-2.8A) A79 A 800 ( 3.7A) A79 A 800 (-3.8A)	1.24A	4rvjB-1hvcA: 13.8	4rvjB-1hvcA: 43.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	A79 A 800 ( 4.0A) A79 A 800 (-2.8A) A79 A 800 (-3.2A) A79 A 800 (-2.7A) A79 A 800 (-3.4A) A79 A 800 ( 4.0A)	1.24A	4rvjB-1hvcA: 13.8	4rvjB-1hvcA: 43.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 VAL A 32 GLY A 49 ILE A 50 ILE A 84	A79 A 800 ( 3.8A) A79 A 800 (-2.7A) A79 A 800 (-3.0A) A79 A 800 (-3.1A) A79 A 800 ( 4.9A) A79 A 800 ( 4.4A) A79 A 800 ( 3.7A) A79 A 800 (-3.8A) A79 A 800 (-3.6A)	0.44A	4rvjB-1hvcA: 13.8	4rvjB-1hvcA: 43.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1hvc	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 VAL A 32 GLY A 49 ILE A 50 ILE A 84	A79 A 800 ( 4.0A) A79 A 800 (-2.8A) A79 A 800 (-3.0A) A79 A 800 (-3.2A) A79 A 800 ( 4.7A) A79 A 800 ( 4.3A) A79 A 800 (-3.4A) A79 A 800 ( 4.0A) A79 A 800 (-3.8A)	0.46A	4rvjB-1hvcA: 13.8	4rvjB-1hvcA: 43.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ig8	HEXOKINASE PII (Saccharomyces cerevisiae)	PF00349 (Hexokinase_1) PF03727 (Hexokinase_2)	5	LEU A 41 GLY A 399 ALA A 401 ILE A 453 ILE A 438	None	0.93A	4rvjB-1ig8A: undetectable	4rvjB-1ig8A: 11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1kae	HISTIDINOL DEHYDROGENASE (Escherichia coli)	PF00815 (Histidinol_dh)	5	GLY A 227 ALA A 228 ASP A 204 GLY A 196 ILE A 206	None	0.92A	4rvjB-1kaeA: undetectable	4rvjB-1kaeA: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1kng	THIOL:DISULFIDE INTERCHANGE PROTEIN CYCY (Bradyrhizobium japonicum)	PF08534 (Redoxin)	5	LEU A 57 ASP A 142 GLY A 145 GLY A 152 ILE A 116	None	0.92A	4rvjB-1kngA: undetectable	4rvjB-1kngA: 25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1l5j	ACONITATE HYDRATASE 2 (Escherichia coli)	PF00330 (Aconitase) PF06434 (Aconitase_2_N) PF11791 (Aconitase_B_N)	5	GLY A 721 ALA A 720 GLY A 715 ILE A 714 ILE A 707	None	0.78A	4rvjB-1l5jA: undetectable	4rvjB-1l5jA: 8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1mpp	PEPSIN (Rhizomucor pusillus)	PF00026 (Asp)	5	LEU A 30 ASP A 32 GLY A 34 ASP A 37 ILE A 120	None	0.79A	4rvjB-1mppA: 7.0	4rvjB-1mppA: 13.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1q9p	HIV-1 PROTEASE (Homo sapiens)	PF00077 (RVP)	6	ASP A 25 GLY A 27 ALA A 28 ASP A 30 VAL A 32 ILE A 84	None	0.52A	4rvjB-1q9pA: 10.5	4rvjB-1q9pA: 84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None	1.23A	4rvjB-1sivA: 18.3	4rvjB-1sivA: 48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1siv	SIV PROTEASE (Simian immunodeficiency virus)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 GLY A 49 ILE A 50 ILE A 84	None	0.50A	4rvjB-1sivA: 18.3	4rvjB-1sivA: 48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1suu	DNA GYRASE SUBUNIT A (Borreliella burgdorferi)	PF03989 (DNA_gyraseA_C)	6	GLY A 780 ALA A 779 VAL A 805 GLY A 722 ILE A 792 ILE A 765	None	1.48A	4rvjB-1suuA: undetectable	4rvjB-1suuA: 14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1v5f	PYRUVATE OXIDASE (Aerococcus viridans)	PF00205 (TPP_enzyme_M) PF02775 (TPP_enzyme_C) PF02776 (TPP_enzyme_N)	5	ASP A 388 ALA A 444 ASP A 442 VAL A 466 ILE A 440	None TPP A1602 (-3.7A) MG A1603 ( 2.8A) None None	0.92A	4rvjB-1v5fA: undetectable	4rvjB-1v5fA: 10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2bc0	NADH OXIDASE (Streptococcus pyogenes)	PF02852 (Pyr_redox_dim) PF07992 (Pyr_redox_2)	5	GLY A 453 ALA A 454 ASP A 456 ILE A 387 ILE A 426	None	0.70A	4rvjB-2bc0A: undetectable	4rvjB-2bc0A: 12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2dws	COPPER-CONTAINING NITRITE REDUCTASE (Rhodobacter sphaeroides)	PF00394 (Cu-oxidase) PF07732 (Cu-oxidase_3)	5	LEU A 90 GLY A 254 ALA A 255 GLY A 347 ILE A 250	None	0.83A	4rvjB-2dwsA: undetectable	4rvjB-2dwsA: 14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2e4u	METABOTROPIC GLUTAMATE RECEPTOR 3 (Rattus norvegicus)	PF01094 (ANF_receptor) PF07562 (NCD3G)	5	LEU A 86 GLY A 92 ASP A 77 ILE A 146 ILE A 79	None	0.88A	4rvjB-2e4uA: undetectable	4rvjB-2e4uA: 11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ewn	BIRA BIFUNCTIONAL PROTEIN (Escherichia coli)	PF02237 (BPL_C) PF03099 (BPL_LplA_LipB) PF08279 (HTH_11)	5	GLY A 186 ALA A 185 GLY A 154 ILE A 153 ILE A 207	BTX A 501 (-3.3A) None None None None	0.81A	4rvjB-2ewnA: undetectable	4rvjB-2ewnA: 20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2fmb	EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE (Equine infectious anemia virus)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 VAL A 32 GLY A 54 ILE A 89	None LP1 A 201 (-2.3A) LP1 A 201 (-3.5A) None LP1 A 201 (-3.6A) LP1 A 201 (-4.2A)	0.83A	4rvjB-2fmbA: 15.2	4rvjB-2fmbA: 33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2fmb	EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE (Equine infectious anemia virus)	PF00077 (RVP)	7	LEU A 23 ASP A 25 GLY A 27 ALA A 28 VAL A 32 GLY A 55 ILE A 89	None LP1 A 201 (-2.3A) LP1 A 201 (-3.8A) LP1 A 201 (-3.5A) None LP1 A 201 (-3.4A) LP1 A 201 (-4.2A)	0.43A	4rvjB-2fmbA: 15.2	4rvjB-2fmbA: 33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2guh	PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR (Rhodococcus jostii)	PF00440 (TetR_N)	6	LEU A 53 GLY A 48 ALA A 47 ASP A 24 VAL A 23 ILE A 22	None	1.44A	4rvjB-2guhA: undetectable	4rvjB-2guhA: 17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2oer	PROBABLE TRANSCRIPTIONAL REGULATOR (Pseudomonas aeruginosa)	PF00440 (TetR_N)	5	LEU A 23 GLY A 53 ALA A 52 ILE A 56 ILE A 27	None	0.82A	4rvjB-2oerA: undetectable	4rvjB-2oerA: 19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2omj	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 (Homo sapiens)	PF00595 (PDZ)	5	LEU A 80 GLY A 45 ALA A 44 GLY A 39 ILE A 13	None	0.84A	4rvjB-2omjA: undetectable	4rvjB-2omjA: 27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2p3e	DIAMINOPIMELATE DECARBOXYLASE (Aquifex aeolicus)	PF00278 (Orn_DAP_Arg_deC) PF02784 (Orn_Arg_deC_N)	5	ALA A 355 VAL A 371 GLY A 345 ILE A 308 ILE A 328	None	0.93A	4rvjB-2p3eA: undetectable	4rvjB-2p3eA: 10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ph3	3-OXOACYL-[ACYL CARRIER PROTEIN] REDUCTASE (Thermus thermophilus)	PF13561 (adh_short_C2)	5	LEU A 28 GLY A 14 ALA A 9 VAL A 56 ILE A 30	None	0.85A	4rvjB-2ph3A: undetectable	4rvjB-2ph3A: 19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2qjc	DIADENOSINE TETRAPHOSPHATASE, PUTATIVE (Trypanosoma brucei)	PF00149 (Metallophos)	5	LEU A 14 GLY A 19 VAL A 137 ILE A 22 ILE A 132	None	0.82A	4rvjB-2qjcA: undetectable	4rvjB-2qjcA: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ri6	2-HYDROXY-6-OXO-6-PH ENYLHEXA-2,4-DIENOAT E HYDROLASE (Paraburkholderia xenovorans)	PF12697 (Abhydrolase_6)	5	LEU A 283 GLY A 63 ALA A 62 GLY A 57 ILE A 280	None	0.72A	4rvjB-2ri6A: undetectable	4rvjB-2ri6A: 16.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None AB1 A 501 (-2.4A) AB1 A 501 (-3.5A) AB1 A 501 ( 3.3A) AB1 A 501 (-3.5A) AB1 A 501 (-3.8A)	1.37A	4rvjB-2rkfA: 20.1	4rvjB-2rkfA: 81.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2rkf	PROTEASE RETROPEPSIN (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 GLY A 49 ILE A 50 ILE A 84	None AB1 A 501 (-2.4A) AB1 A 501 (-3.9A) AB1 A 501 (-3.5A) AB1 A 501 (-3.8A) AB1 A 501 (-3.5A) AB1 A 501 (-3.8A) AB1 A 501 ( 4.2A)	0.53A	4rvjB-2rkfA: 20.1	4rvjB-2rkfA: 81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2rsp	RSV PROTEASE (Rous sarcoma virus)	PF00077 (RVP)	5	LEU A 35 ASP A 37 GLY A 39 ALA A 40 ILE A 108	None	0.45A	4rvjB-2rspA: 13.0	4rvjB-2rspA: 29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wsk	GLYCOGEN DEBRANCHING ENZYME (Escherichia coli)	PF00128 (Alpha-amylase) PF02922 (CBM_48)	5	LEU A 188 GLY A 255 ALA A 254 ILE A 248 ILE A 185	None	0.77A	4rvjB-2wskA: undetectable	4rvjB-2wskA: 9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2yfq	NAD-SPECIFIC GLUTAMATE DEHYDROGENASE (Peptoniphilus asaccharolyticus)	PF00208 (ELFV_dehydrog) PF02812 (ELFV_dehydrog_N)	6	LEU A 317 ALA A 213 ASP A 212 GLY A 236 ILE A 231 ILE A 208	None	1.28A	4rvjB-2yfqA: undetectable	4rvjB-2yfqA: 15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3gf7	GLUTACONYL-COA DECARBOXYLASE SUBUNIT A ([Clostridium] symbiosum)	PF01039 (Carboxyl_trans)	5	LEU A 148 GLY A 191 ALA A 213 GLY A 256 ILE A 189	None	0.88A	4rvjB-3gf7A: undetectable	4rvjB-3gf7A: 11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3i4o	TRANSLATION INITIATION FACTOR IF-1 (Mycobacterium tuberculosis)	PF01176 (eIF-1a)	5	LEU A 27 GLY A 66 ALA A 35 VAL A 14 ILE A 25	None	0.91A	4rvjB-3i4oA: undetectable	4rvjB-3i4oA: 20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3kl7	PUTATIVE METAL-DEPENDENT HYDROLASE (Parabacteroides distasonis)	PF13483 (Lactamase_B_3)	5	LEU A 156 GLY A 153 ASP A 120 ILE A 77 ILE A 130	None	0.83A	4rvjB-3kl7A: undetectable	4rvjB-3kl7A: 17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mdo	PUTATIVE PHOSPHORIBOSYLFORMYL GLYCINAMIDINE CYCLO-LIGASE (Parabacteroides distasonis)	PF02769 (AIRS_C)	6	LEU A 251 GLY A 256 ALA A 255 ASP A 246 ILE A 319 ILE A 248	None	1.09A	4rvjB-3mdoA: undetectable	4rvjB-3mdoA: 12.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ALA A 28 ASP A 30 VAL A 32 GLY A 48 ILE A 84	None	0.82A	4rvjB-3mwsA: 19.2	4rvjB-3mwsA: 70.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None	1.28A	4rvjB-3mwsA: 19.2	4rvjB-3mwsA: 70.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 VAL A 32 ILE A 84	None	0.50A	4rvjB-3mwsA: 19.2	4rvjB-3mwsA: 70.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3mws	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 VAL A 32 GLY A 49 ILE A 50 ILE A 84	None	0.48A	4rvjB-3mwsA: 19.2	4rvjB-3mwsA: 70.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3pdx	TYROSINE AMINOTRANSFERASE (Mus musculus)	PF00155 (Aminotran_1_2)	5	LEU A 331 GLY A 325 ALA A 326 VAL A 93 ILE A 330	None	0.93A	4rvjB-3pdxA: undetectable	4rvjB-3pdxA: 16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3s52	PUTATIVE FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (Yersinia pestis)	PF01557 (FAA_hydrolase)	5	GLY A 97 ALA A 74 VAL A 19 ILE A 54 ILE A 186	None	0.92A	4rvjB-3s52A: undetectable	4rvjB-3s52A: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3slz	GAG-PRO-POL POLYPROTEIN (Murine leukemia virus)	PF00077 (RVP)	6	LEU A 30 ASP A 32 GLY A 34 ALA A 35 VAL A 39 GLY A 56	None 3TL A 126 (-2.4A) 3TL A 126 (-3.1A) 3TL A 126 ( 4.0A) None 3TL A 126 (-3.4A)	0.52A	4rvjB-3slzA: 11.9	4rvjB-3slzA: 25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3sm9	METABOTROPIC GLUTAMATE RECEPTOR 3 (Homo sapiens)	PF01094 (ANF_receptor)	5	LEU A 61 GLY A 67 ASP A 52 ILE A 121 ILE A 54	None	0.92A	4rvjB-3sm9A: undetectable	4rvjB-3sm9A: 12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3snh	DYNAMIN-1 (Homo sapiens)	PF00169 (PH) PF00350 (Dynamin_N) PF01031 (Dynamin_M) PF02212 (GED)	6	LEU A 170 GLY A 202 ALA A 173 VAL A 164 GLY A 38 ILE A 171	None	1.49A	4rvjB-3snhA: undetectable	4rvjB-3snhA: 9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3t05	PYRUVATE KINASE (Staphylococcus aureus)	PF00224 (PK) PF00391 (PEP-utilizers) PF02887 (PK_C)	5	GLY A 575 VAL A 487 GLY A 483 ILE A 482 ILE A 570	None	0.92A	4rvjB-3t05A: undetectable	4rvjB-3t05A: 9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3t2y	SULFIDE-QUINONE REDUCTASE, PUTATIVE (Acidithiobacillus ferrooxidans)	PF07992 (Pyr_redox_2)	5	LEU A 7 GLY A 106 ALA A 303 GLY A 281 ILE A 103	FAD A 500 (-4.7A) FAD A 500 (-3.1A) None None None	0.70A	4rvjB-3t2yA: undetectable	4rvjB-3t2yA: 13.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	SO4 A 101 (-4.2A) 017 A 201 (-2.6A) 017 A 201 (-3.5A) 017 A 201 (-3.5A) 017 A 201 (-4.0A) 017 A 201 (-3.3A)	1.38A	4rvjB-3t3cA: 18.4	4rvjB-3t3cA: 75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3t3c	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 VAL A 32 GLY A 49 ILE A 50	SO4 A 101 (-4.2A) 017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-3.5A) 017 A 201 (-4.2A) None 017 A 201 (-4.0A) 017 A 201 (-3.3A)	0.41A	4rvjB-3t3cA: 18.4	4rvjB-3t3cA: 75.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None 017 A 201 (-2.6A) 017 A 201 (-3.4A) 017 A 201 (-3.3A) 017 A 201 (-3.0A) 017 A 201 (-3.3A)	1.26A	4rvjB-3ttpA: 19.4	4rvjB-3ttpA: 78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3ttp	HIV-1 PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 GLY A 49 ILE A 50 ILE A 84	None 017 A 201 (-2.6A) 017 A 201 (-3.6A) 017 A 201 (-3.4A) 017 A 201 (-4.6A) 017 A 201 (-3.0A) 017 A 201 (-3.3A) 017 A 201 (-4.7A)	0.56A	4rvjB-3ttpA: 19.4	4rvjB-3ttpA: 78.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None 017 A 202 ( 2.5A) 017 A 201 (-3.4A) 017 A 201 (-3.2A) 017 A 202 (-2.9A) 017 A 201 ( 3.5A)	1.29A	4rvjB-3u7sA: 19.8	4rvjB-3u7sA: 79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3u7s	POL POLYPROTEIN (Human immunodeficiency virus 1)	PF00077 (RVP)	7	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 GLY A 49 ILE A 50	None 017 A 202 ( 2.5A) 017 A 201 ( 3.5A) 017 A 201 (-3.4A) 017 A 201 ( 4.0A) 017 A 202 (-2.9A) 017 A 201 ( 3.5A)	0.30A	4rvjB-3u7sA: 19.8	4rvjB-3u7sA: 79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3uzu	RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A (Burkholderia pseudomallei)	PF00398 (RrnaAD)	5	LEU A 88 GLY A 48 VAL A 56 GLY A 116 ILE A 45	None	0.80A	4rvjB-3uzuA: undetectable	4rvjB-3uzuA: 17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4emk	U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5 U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7 (Schizosaccharomyces pombe)	PF01423 (LSM)	5	LEU A 10 GLY C 84 VAL C 88 GLY C 48 ILE C 49	None	0.89A	4rvjB-4emkA: undetectable	4rvjB-4emkA: 20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4g6c	BETA-HEXOSAMINIDASE 1 (Burkholderia cenocepacia)	PF00933 (Glyco_hydro_3)	5	ASP A 128 GLY A 174 VAL A 136 ILE A 215 ILE A 137	None	0.83A	4rvjB-4g6cA: undetectable	4rvjB-4g6cA: 15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4inj	LMO1638 PROTEIN (Listeria monocytogenes)	PF02016 (Peptidase_S66)	5	LEU A 162 ALA A 309 GLY A 306 ILE A 305 ILE A 321	None	0.82A	4rvjB-4injA: undetectable	4rvjB-4injA: 16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ky0	PROTON/GLUTAMATE SYMPORTER, SDF FAMILY (Thermococcus kodakarensis)	PF00375 (SDF)	5	GLY A 210 ALA A 213 VAL A 41 GLY A 25 ILE A 45	None	0.91A	4rvjB-4ky0A: undetectable	4rvjB-4ky0A: 14.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	ALA A 28 ASP A 30 VAL A 32 GLY A 48 ILE A 84	RIT A 500 (-3.6A) RIT A 500 (-4.8A) None RIT A 500 (-4.8A) RIT A 500 (-4.3A)	0.80A	4rvjB-4njvA: 20.0	4rvjB-4njvA: 98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None RIT A 500 (-2.4A) RIT A 500 (-3.6A) RIT A 500 (-3.2A) RIT A 500 (-3.4A) RIT A 500 (-4.3A)	1.28A	4rvjB-4njvA: 20.0	4rvjB-4njvA: 98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	7	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 VAL A 32 ILE A 84	None RIT A 500 (-2.4A) RIT A 500 (-3.9A) RIT A 500 (-3.6A) RIT A 500 (-4.8A) None RIT A 500 (-4.3A)	0.46A	4rvjB-4njvA: 20.0	4rvjB-4njvA: 98.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4njv	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 VAL A 32 GLY A 49 ILE A 50 ILE A 84	None RIT A 500 (-2.4A) RIT A 500 (-3.9A) RIT A 500 (-3.6A) None RIT A 500 (-3.4A) RIT A 500 (-4.3A) RIT A 500 (-4.3A)	0.40A	4rvjB-4njvA: 20.0	4rvjB-4njvA: 98.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4nnm	TAX1-BINDING PROTEIN 3 (Homo sapiens)	PF00595 (PDZ)	5	LEU A 108 GLY A 71 ALA A 70 GLY A 65 ILE A 19	None	0.93A	4rvjB-4nnmA: undetectable	4rvjB-4nnmA: 19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4nzr	PROTEIN M TD (Mycoplasma genitalium)	no annotation	6	LEU M 278 GLY M 270 ALA M 248 ASP M 250 ILE M 267 ILE M 251	None None None None GOL M 501 ( 4.3A) None	1.25A	4rvjB-4nzrM: undetectable	4rvjB-4nzrM: 13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4oy7	PUTATIVE SECRETED CELLULOSE BINDING PROTEIN (Streptomyces coelicolor)	PF03067 (LPMO_10)	5	LEU A 194 GLY A 131 ALA A 132 GLY A 229 ILE A 134	None	0.93A	4rvjB-4oy7A: undetectable	4rvjB-4oy7A: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4pyr	PUTATIVE BRANCHED-CHAIN AMINO ACID ABC TRANSPORTER (Chromobacterium violaceum)	PF04348 (LppC)	5	LEU A 166 VAL A 88 GLY A 107 ILE A 337 ILE A 146	None	0.68A	4rvjB-4pyrA: undetectable	4rvjB-4pyrA: 14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4qi6	CELLOBIOSE DEHYDROGENASE (Crassicarpon hotsonii)	PF00732 (GMC_oxred_N) PF00734 (CBM_1) PF05199 (GMC_oxred_C) PF16010 (CDH-cyt)	5	LEU A 489 GLY A 481 ALA A 480 ILE A 477 ILE A 488	None FAD A 902 (-3.6A) FAD A 902 (-3.9A) None None	0.92A	4rvjB-4qi6A: undetectable	4rvjB-4qi6A: 8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ql6	CARBOXY-TERMINAL PROCESSING PROTEASE (Chlamydia trachomatis)	PF00595 (PDZ) PF03572 (Peptidase_S41)	5	LEU A 360 GLY A 400 VAL A 449 ILE A 459 ILE A 395	None	0.89A	4rvjB-4ql6A: undetectable	4rvjB-4ql6A: 10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4qpn	PROTEIN-LYSINE METHYLTRANSFERASE METTL21B (Homo sapiens)	PF10294 (Methyltransf_16)	5	LEU A 109 GLY A 83 ALA A 84 ILE A 80 ILE A 112	None SAH A 301 (-3.6A) None None None	0.76A	4rvjB-4qpnA: undetectable	4rvjB-4qpnA: 17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xib	E3 UBIQUITIN-PROTEIN LIGASE MIB1 (Homo sapiens)	PF00569 (ZZ) PF06701 (MIB_HERC2)	6	LEU A 215 GLY A 154 ALA A 155 ASP A 220 GLY A 223 ILE A 151	None	1.40A	4rvjB-4xibA: undetectable	4rvjB-4xibA: 14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xll	DJ-1 FAMILY PROTEIN (Toxoplasma gondii)	PF01965 (DJ-1_PfpI)	5	LEU A 168 GLY A 29 ALA A 28 ILE A 22 ILE A 165	None	0.84A	4rvjB-4xllA: undetectable	4rvjB-4xllA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4xr9	CALS8 (Micromonospora echinospora)	PF00984 (UDPG_MGDP_dh) PF03720 (UDPG_MGDP_dh_C) PF03721 (UDPG_MGDP_dh_N)	5	ASP A 248 VAL A 249 GLY A 452 ILE A 451 ILE A 250	None	0.91A	4rvjB-4xr9A: undetectable	4rvjB-4xr9A: 14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4ydf	HTLV-1 PROTEASE (Primate T-lymphotropic virus 1)	PF00077 (RVP)	7	LEU A 30 ASP A 32 GLY A 34 ALA A 35 VAL A 39 GLY A 58 ILE A 100	None 4B1 A 201 (-2.9A) 4B1 A 201 ( 4.6A) 4B1 A 201 (-3.6A) None 4B1 A 201 (-3.4A) 4B1 A 201 (-4.8A)	0.67A	4rvjB-4ydfA: 13.4	4rvjB-4ydfA: 33.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5b18	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	5	GLY A 27 ALA A 28 ASP A 30 GLY A 49 ILE A 84	None	0.86A	4rvjB-5b18A: 18.4	4rvjB-5b18A: 79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cni	METABOTROPIC GLUTAMATE RECEPTOR 2 (Homo sapiens)	PF01094 (ANF_receptor)	5	LEU A 79 GLY A 85 ASP A 70 ILE A 140 ILE A 72	None	0.92A	4rvjB-5cniA: undetectable	4rvjB-5cniA: 11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cw2	PUTATIVE EPOXIDE HYDROLASE EPHA (Mycolicibacterium thermoresistibile)	no annotation	5	LEU C 315 GLY C 53 ALA C 52 ILE C 46 ILE C 312	None	0.77A	4rvjB-5cw2C: undetectable	4rvjB-5cw2C: 15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cw5	BRCA1/BRCA2-CONTAINI NG COMPLEX SUBUNIT 3 (Camponotus floridanus)	PF01398 (JAB)	5	LEU A 79 VAL A 89 GLY A 33 ILE A 51 ILE A 36	None	0.91A	4rvjB-5cw5A: undetectable	4rvjB-5cw5A: 16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ej1	PUTATIVE CELLULOSE SYNTHASE (Rhodobacter sphaeroides)	PF00535 (Glycos_transf_2) PF03552 (Cellulose_synt) PF07238 (PilZ)	5	LEU A 688 GLY A 614 VAL A 681 GLY A 655 ILE A 637	None C2E A 919 (-3.4A) None None None	0.75A	4rvjB-5ej1A: undetectable	4rvjB-5ej1A: 9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ema	SORTING NEXIN-27 (Rattus norvegicus)	PF00595 (PDZ)	5	LEU A 130 GLY A 94 ALA A 93 GLY A 88 ILE A 46	None	0.89A	4rvjB-5emaA: undetectable	4rvjB-5emaA: 24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5g5g	PUTATIVE XANTHINE DEHYDROGENASE YAGR MOLYBDENUM-BINDING SU SUBUNIT (Escherichia coli)	PF00941 (FAD_binding_5) PF03450 (CO_deh_flav_C)	5	LEU B 172 ALA B 94 ASP B 164 VAL B 167 ILE B 227	None None FAD B 321 (-3.9A) None None	0.93A	4rvjB-5g5gB: undetectable	4rvjB-5g5gB: 15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5g5g	PUTATIVE XANTHINE DEHYDROGENASE YAGT IRON-SULFUR-BINDING SUBUNIT (Escherichia coli)	PF00111 (Fer2) PF01799 (Fer2_2)	5	GLY A 211 ALA A 212 ASP A 154 GLY A 159 ILE A 216	None None None FES A 230 (-4.2A) None	0.90A	4rvjB-5g5gA: undetectable	4rvjB-5g5gA: 24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ija	HYDROGENASE-SPECIFIC MATURATION ENDOPEPTIDASE (Thermococcus kodakarensis)	PF01750 (HycI)	6	GLY A 17 ALA A 18 ASP A 57 GLY A 23 ILE A 25 ILE A 117	None	1.48A	4rvjB-5ijaA: undetectable	4rvjB-5ijaA: 18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5it1	PUTATIVE CYTOCHROME P450 (Streptomyces peucetius)	PF00067 (p450)	5	ALA A 238 VAL A 150 GLY A 350 ILE A 349 ILE A 151	HEM A 401 (-3.1A) None HEM A 401 ( 3.7A) HEM A 401 (-4.4A) None	0.92A	4rvjB-5it1A: undetectable	4rvjB-5it1A: 13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5jxk	ASP/GLU-SPECIFIC DIPEPTIDYL-PEPTIDASE (Porphyromonas endodontalis)	PF10459 (Peptidase_S46)	5	GLY A 583 ALA A 594 VAL A 263 ILE A 689 ILE A 581	None	0.91A	4rvjB-5jxkA: undetectable	4rvjB-5jxkA: 8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5kzn	METABOTROPIC GLUTAMATE RECEPTOR 2 (Homo sapiens)	PF01094 (ANF_receptor) PF07562 (NCD3G)	5	LEU A 79 GLY A 85 ASP A 70 ILE A 140 ILE A 72	None	0.90A	4rvjB-5kznA: undetectable	4rvjB-5kznA: 11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5n6m	APOLIPOPROTEIN N-ACYLTRANSFERASE (Pseudomonas aeruginosa)	PF00795 (CN_hydrolase)	5	GLY A 324 ALA A 372 VAL A 400 ILE A 265 ILE A 377	None	0.88A	4rvjB-5n6mA: undetectable	4rvjB-5n6mA: 9.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	6	LEU A 23 ASP A 25 ALA A 28 ASP A 29 GLY A 49 ILE A 50	None	1.28A	4rvjB-5t2zA: 19.6	4rvjB-5t2zA: 85.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5t2z	PROTEASE (Human immunodeficiency virus 1)	PF00077 (RVP)	9	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 VAL A 32 GLY A 49 ILE A 50 ILE A 84	None	0.51A	4rvjB-5t2zA: 19.6	4rvjB-5t2zA: 85.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5tf0	GLYCOSYL HYDROLASE FAMILY 3 N-TERMINAL DOMAIN PROTEIN (Bacteroides intestinalis)	PF00933 (Glyco_hydro_3) PF01915 (Glyco_hydro_3_C) PF14310 (Fn3-like)	5	GLY A 452 VAL A 461 GLY A 589 ILE A 588 ILE A 463	None	0.88A	4rvjB-5tf0A: undetectable	4rvjB-5tf0A: 8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5z2e	DIHYDRODIPICOLINATE REDUCTASE (Paenisporosarcina sp. TG-14)	no annotation	6	GLY A 259 ALA A 124 VAL A 96 GLY A 242 ILE A 129 ILE A 122	None	1.48A	4rvjB-5z2eA: undetectable	4rvjB-5z2eA: 21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6fiv	RETROPEPSIN (Feline immunodeficiency virus)	PF00077 (RVP)	5	LEU A 28 ASP A 30 GLY A 32 ALA A 33 GLY A 58	None 3TL A 201 (-3.5A) 3TL A 201 (-3.4A) 3TL A 201 (-4.0A) 3TL A 201 (-3.4A)	0.27A	4rvjB-6fivA: 15.8	4rvjB-6fivA: 31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6upj	HIV-2 PROTEASE (Human immunodeficiency virus 2)	PF00077 (RVP)	8	LEU A 23 ASP A 25 GLY A 27 ALA A 28 ASP A 30 GLY A 49 ILE A 50 ILE A 84	None NIU A 100 (-2.8A) NIU A 100 (-4.5A) NIU A 100 (-3.6A) None NIU A 100 ( 3.8A) NIU A 100 (-3.9A) None	0.77A	4rvjB-6upjA: 17.6	4rvjB-6upjA: 47.47

[["4RVJ_B_478B101_2","1czi","Bos taurus","CHYMOSIN","PF00026(Asp)",5,"ASP E 215;GLY E 217;VAL E 222;GLY E  76;ILE E 300","None","0.77A","4rvjB-1cziE:6.6","4rvjB-1cziE:17.79"],["4RVJ_B_478B101_2","1czi","Bos taurus","CHYMOSIN","PF00026(Asp)",5,"LEU E  30;ASP E  32;GLY E  34;ASP E  37;ILE E 120","None","0.58A","4rvjB-1cziE:6.6","4rvjB-1cziE:17.79"],["4RVJ_B_478B101_2","1deu","Homo sapiens","PROCATHEPSIN X","PF00112(Peptidase_C1)",6,"LEU A  57;GLY A  87;ALA A  83;ASP A  81;GLY A 130;ILE A 241","None","1.26A","4rvjB-1deuA:undetectable","4rvjB-1deuA:16.55"],["4RVJ_B_478B101_2","1ef7","Homo sapiens","CATHEPSIN X","PF00112(Peptidase_C1)",6,"LEU A  57;GLY A  87;ALA A  83;ASP A  81;GLY A 130;ILE A 241","None","1.28A","4rvjB-1ef7A:undetectable","4rvjB-1ef7A:19.01"],["4RVJ_B_478B101_2","1ek6","Homo sapiens","UDP-GALACTOSE 4-EPIMERASE","PF16363(GDP_Man_Dehyd)",5,"LEU A  68;GLY A  90;ALA A  89;ILE A 164;ILE A  67","None;NAI A 400 (-4.1A);NAI A 400 (-3.7A);None;NAI A 400 (-3.8A)","0.79A","4rvjB-1ek6A:undetectable","4rvjB-1ek6A:14.78"],["4RVJ_B_478B101_2","1gpe","Penicillium amagasakiense","PROTEIN (GLUCOSE OXIDASE)","PF00732(GMC_oxred_N);PF05199(GMC_oxred_C)",6,"LEU A 302;GLY A 294;ALA A 293;VAL A 254;ILE A 551;ILE A 301","None;FAD A 600 ( 3.8A);FAD A 600 (-3.6A);FAD A 600 (-4.0A);None;None","1.33A","4rvjB-1gpeA:undetectable","4rvjB-1gpeA:9.23"],["4RVJ_B_478B101_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  30;VAL A  32;GLY A  48;ILE A  84","A79 A 800 (-3.1A);A79 A 800 ( 4.9A);A79 A 800 ( 4.4A);A79 A 800 (-3.6A);A79 A 800 (-3.6A)","0.84A","4rvjB-1hvcA:13.8","4rvjB-1hvcA:43.84"],["4RVJ_B_478B101_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ALA A  28;ASP A  30;VAL A  32;GLY A  48;ILE A  84","A79 A 800 ( 4.0A);A79 A 800 (-3.2A);A79 A 800 ( 4.7A);A79 A 800 ( 4.3A);A79 A 800 (-4.1A);A79 A 800 (-3.8A)","0.95A","4rvjB-1hvcA:13.8","4rvjB-1hvcA:43.84"],["4RVJ_B_478B101_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","A79 A 800 ( 3.8A);A79 A 800 (-2.7A);A79 A 800 (-3.1A);A79 A 800 (-2.8A);A79 A 800 ( 3.7A);A79 A 800 (-3.8A)","1.24A","4rvjB-1hvcA:13.8","4rvjB-1hvcA:43.84"],["4RVJ_B_478B101_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","A79 A 800 ( 4.0A);A79 A 800 (-2.8A);A79 A 800 (-3.2A);A79 A 800 (-2.7A);A79 A 800 (-3.4A);A79 A 800 ( 4.0A)","1.24A","4rvjB-1hvcA:13.8","4rvjB-1hvcA:43.84"],["4RVJ_B_478B101_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;VAL A  32;GLY A  49;ILE A  50;ILE A  84","A79 A 800 ( 3.8A);A79 A 800 (-2.7A);A79 A 800 (-3.0A);A79 A 800 (-3.1A);A79 A 800 ( 4.9A);A79 A 800 ( 4.4A);A79 A 800 ( 3.7A);A79 A 800 (-3.8A);A79 A 800 (-3.6A)","0.44A","4rvjB-1hvcA:13.8","4rvjB-1hvcA:43.84"],["4RVJ_B_478B101_2","1hvc","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;VAL A  32;GLY A  49;ILE A  50;ILE A  84","A79 A 800 ( 4.0A);A79 A 800 (-2.8A);A79 A 800 (-3.0A);A79 A 800 (-3.2A);A79 A 800 ( 4.7A);A79 A 800 ( 4.3A);A79 A 800 (-3.4A);A79 A 800 ( 4.0A);A79 A 800 (-3.8A)","0.46A","4rvjB-1hvcA:13.8","4rvjB-1hvcA:43.84"],["4RVJ_B_478B101_2","1ig8","Saccharomyces cerevisiae","HEXOKINASE PII","PF00349(Hexokinase_1);PF03727(Hexokinase_2)",5,"LEU A  41;GLY A 399;ALA A 401;ILE A 453;ILE A 438","None","0.93A","4rvjB-1ig8A:undetectable","4rvjB-1ig8A:11.92"],["4RVJ_B_478B101_2","1kae","Escherichia coli","HISTIDINOL DEHYDROGENASE","PF00815(Histidinol_dh)",5,"GLY A 227;ALA A 228;ASP A 204;GLY A 196;ILE A 206","None","0.92A","4rvjB-1kaeA:undetectable","4rvjB-1kaeA:14.42"],["4RVJ_B_478B101_2","1kng","Bradyrhizobium japonicum","THIOL:DISULFIDE INTERCHANGE PROTEIN CYCY","PF08534(Redoxin)",5,"LEU A  57;ASP A 142;GLY A 145;GLY A 152;ILE A 116","None","0.92A","4rvjB-1kngA:undetectable","4rvjB-1kngA:25.52"],["4RVJ_B_478B101_2","1l5j","Escherichia coli","ACONITATE HYDRATASE 2","PF00330(Aconitase);PF06434(Aconitase_2_N);PF11791(Aconitase_B_N)",5,"GLY A 721;ALA A 720;GLY A 715;ILE A 714;ILE A 707","None","0.78A","4rvjB-1l5jA:undetectable","4rvjB-1l5jA:8.31"],["4RVJ_B_478B101_2","1mpp","Rhizomucor pusillus","PEPSIN","PF00026(Asp)",5,"LEU A  30;ASP A  32;GLY A  34;ASP A  37;ILE A 120","None","0.79A","4rvjB-1mppA:7.0","4rvjB-1mppA:13.02"],["4RVJ_B_478B101_2","1q9p","Homo sapiens","HIV-1 PROTEASE","PF00077(RVP)",6,"ASP A  25;GLY A  27;ALA A  28;ASP A  30;VAL A  32;ILE A  84","None","0.52A","4rvjB-1q9pA:10.5","4rvjB-1q9pA:84.21"],["4RVJ_B_478B101_2","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None","1.23A","4rvjB-1sivA:18.3","4rvjB-1sivA:48.48"],["4RVJ_B_478B101_2","1siv","Simian immunodeficiency virus","SIV PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;GLY A  49;ILE A  50;ILE A  84","None","0.50A","4rvjB-1sivA:18.3","4rvjB-1sivA:48.48"],["4RVJ_B_478B101_2","1suu","Borreliella burgdorferi","DNA GYRASE SUBUNIT A","PF03989(DNA_gyraseA_C)",6,"GLY A 780;ALA A 779;VAL A 805;GLY A 722;ILE A 792;ILE A 765","None","1.48A","4rvjB-1suuA:undetectable","4rvjB-1suuA:14.42"],["4RVJ_B_478B101_2","1v5f","Aerococcus viridans","PYRUVATE OXIDASE","PF00205(TPP_enzyme_M);PF02775(TPP_enzyme_C);PF02776(TPP_enzyme_N)",5,"ASP A 388;ALA A 444;ASP A 442;VAL A 466;ILE A 440","None;TPP A1602 (-3.7A); MG A1603 ( 2.8A);None;None","0.92A","4rvjB-1v5fA:undetectable","4rvjB-1v5fA:10.63"],["4RVJ_B_478B101_2","2bc0","Streptococcus pyogenes","NADH OXIDASE","PF02852(Pyr_redox_dim);PF07992(Pyr_redox_2)",5,"GLY A 453;ALA A 454;ASP A 456;ILE A 387;ILE A 426","None","0.70A","4rvjB-2bc0A:undetectable","4rvjB-2bc0A:12.50"],["4RVJ_B_478B101_2","2dws","Rhodobacter sphaeroides","COPPER-CONTAINING NITRITE REDUCTASE","PF00394(Cu-oxidase);PF07732(Cu-oxidase_3)",5,"LEU A  90;GLY A 254;ALA A 255;GLY A 347;ILE A 250","None","0.83A","4rvjB-2dwsA:undetectable","4rvjB-2dwsA:14.47"],["4RVJ_B_478B101_2","2e4u","Rattus norvegicus","METABOTROPIC GLUTAMATE RECEPTOR 3","PF01094(ANF_receptor);PF07562(NCD3G)",5,"LEU A  86;GLY A  92;ASP A  77;ILE A 146;ILE A  79","None","0.88A","4rvjB-2e4uA:undetectable","4rvjB-2e4uA:11.15"],["4RVJ_B_478B101_2","2ewn","Escherichia coli","BIRA BIFUNCTIONAL PROTEIN","PF02237(BPL_C);PF03099(BPL_LplA_LipB);PF08279(HTH_11)",5,"GLY A 186;ALA A 185;GLY A 154;ILE A 153;ILE A 207","BTX A 501 (-3.3A);None;None;None;None","0.81A","4rvjB-2ewnA:undetectable","4rvjB-2ewnA:20.75"],["4RVJ_B_478B101_2","2fmb","Equine infectious anemia virus","EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;VAL A  32;GLY A  54;ILE A  89","None;LP1 A 201 (-2.3A);LP1 A 201 (-3.5A);None;LP1 A 201 (-3.6A);LP1 A 201 (-4.2A)","0.83A","4rvjB-2fmbA:15.2","4rvjB-2fmbA:33.33"],["4RVJ_B_478B101_2","2fmb","Equine infectious anemia virus","EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE","PF00077(RVP)",7,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;VAL A  32;GLY A  55;ILE A  89","None;LP1 A 201 (-2.3A);LP1 A 201 (-3.8A);LP1 A 201 (-3.5A);None;LP1 A 201 (-3.4A);LP1 A 201 (-4.2A)","0.43A","4rvjB-2fmbA:15.2","4rvjB-2fmbA:33.33"],["4RVJ_B_478B101_2","2guh","Rhodococcus jostii","PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR","PF00440(TetR_N)",6,"LEU A  53;GLY A  48;ALA A  47;ASP A  24;VAL A  23;ILE A  22","None","1.44A","4rvjB-2guhA:undetectable","4rvjB-2guhA:17.54"],["4RVJ_B_478B101_2","2oer","Pseudomonas aeruginosa","PROBABLE TRANSCRIPTIONAL REGULATOR","PF00440(TetR_N)",5,"LEU A  23;GLY A  53;ALA A  52;ILE A  56;ILE A  27","None","0.82A","4rvjB-2oerA:undetectable","4rvjB-2oerA:19.00"],["4RVJ_B_478B101_2","2omj","Homo sapiens","RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12","PF00595(PDZ)",5,"LEU A  80;GLY A  45;ALA A  44;GLY A  39;ILE A  13","None","0.84A","4rvjB-2omjA:undetectable","4rvjB-2omjA:27.52"],["4RVJ_B_478B101_2","2p3e","Aquifex aeolicus","DIAMINOPIMELATE DECARBOXYLASE","PF00278(Orn_DAP_Arg_deC);PF02784(Orn_Arg_deC_N)",5,"ALA A 355;VAL A 371;GLY A 345;ILE A 308;ILE A 328","None","0.93A","4rvjB-2p3eA:undetectable","4rvjB-2p3eA:10.71"],["4RVJ_B_478B101_2","2ph3","Thermus thermophilus","3-OXOACYL-[ACYL CARRIER PROTEIN] REDUCTASE","PF13561(adh_short_C2)",5,"LEU A  28;GLY A  14;ALA A   9;VAL A  56;ILE A  30","None","0.85A","4rvjB-2ph3A:undetectable","4rvjB-2ph3A:19.18"],["4RVJ_B_478B101_2","2qjc","Trypanosoma brucei","DIADENOSINE TETRAPHOSPHATASE, PUTATIVE","PF00149(Metallophos)",5,"LEU A  14;GLY A  19;VAL A 137;ILE A  22;ILE A 132","None","0.82A","4rvjB-2qjcA:undetectable","4rvjB-2qjcA:19.37"],["4RVJ_B_478B101_2","2ri6","Paraburkholderia xenovorans","2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE","PF12697(Abhydrolase_6)",5,"LEU A 283;GLY A  63;ALA A  62;GLY A  57;ILE A 280","None","0.72A","4rvjB-2ri6A:undetectable","4rvjB-2ri6A:16.34"],["4RVJ_B_478B101_2","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None;AB1 A 501 (-2.4A);AB1 A 501 (-3.5A);AB1 A 501 ( 3.3A);AB1 A 501 (-3.5A);AB1 A 501 (-3.8A)","1.37A","4rvjB-2rkfA:20.1","4rvjB-2rkfA:81.82"],["4RVJ_B_478B101_2","2rkf","Human immunodeficiency virus 1","PROTEASE RETROPEPSIN","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;GLY A  49;ILE A  50;ILE A  84","None;AB1 A 501 (-2.4A);AB1 A 501 (-3.9A);AB1 A 501 (-3.5A);AB1 A 501 (-3.8A);AB1 A 501 (-3.5A);AB1 A 501 (-3.8A);AB1 A 501 ( 4.2A)","0.53A","4rvjB-2rkfA:20.1","4rvjB-2rkfA:81.82"],["4RVJ_B_478B101_2","2rsp","Rous sarcoma virus","RSV PROTEASE","PF00077(RVP)",5,"LEU A  35;ASP A  37;GLY A  39;ALA A  40;ILE A 108","None","0.45A","4rvjB-2rspA:13.0","4rvjB-2rspA:29.60"],["4RVJ_B_478B101_2","2wsk","Escherichia coli","GLYCOGEN DEBRANCHING ENZYME","PF00128(Alpha-amylase);PF02922(CBM_48)",5,"LEU A 188;GLY A 255;ALA A 254;ILE A 248;ILE A 185","None","0.77A","4rvjB-2wskA:undetectable","4rvjB-2wskA:9.39"],["4RVJ_B_478B101_2","2yfq","Peptoniphilus asaccharolyticus","NAD-SPECIFIC GLUTAMATE DEHYDROGENASE","PF00208(ELFV_dehydrog);PF02812(ELFV_dehydrog_N)",6,"LEU A 317;ALA A 213;ASP A 212;GLY A 236;ILE A 231;ILE A 208","None","1.28A","4rvjB-2yfqA:undetectable","4rvjB-2yfqA:15.42"],["4RVJ_B_478B101_2","3gf7","[Clostridium] symbiosum","GLUTACONYL-COA DECARBOXYLASE SUBUNIT A","PF01039(Carboxyl_trans)",5,"LEU A 148;GLY A 191;ALA A 213;GLY A 256;ILE A 189","None","0.88A","4rvjB-3gf7A:undetectable","4rvjB-3gf7A:11.96"],["4RVJ_B_478B101_2","3i4o","Mycobacterium tuberculosis","TRANSLATION INITIATION FACTOR IF-1","PF01176(eIF-1a)",5,"LEU A  27;GLY A  66;ALA A  35;VAL A  14;ILE A  25","None","0.91A","4rvjB-3i4oA:undetectable","4rvjB-3i4oA:20.79"],["4RVJ_B_478B101_2","3kl7","Parabacteroides distasonis","PUTATIVE METAL-DEPENDENT HYDROLASE","PF13483(Lactamase_B_3)",5,"LEU A 156;GLY A 153;ASP A 120;ILE A  77;ILE A 130","None","0.83A","4rvjB-3kl7A:undetectable","4rvjB-3kl7A:17.41"],["4RVJ_B_478B101_2","3mdo","Parabacteroides distasonis","PUTATIVE PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE","PF02769(AIRS_C)",6,"LEU A 251;GLY A 256;ALA A 255;ASP A 246;ILE A 319;ILE A 248","None","1.09A","4rvjB-3mdoA:undetectable","4rvjB-3mdoA:12.40"],["4RVJ_B_478B101_2","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  30;VAL A  32;GLY A  48;ILE A  84","None","0.82A","4rvjB-3mwsA:19.2","4rvjB-3mwsA:70.71"],["4RVJ_B_478B101_2","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None","1.28A","4rvjB-3mwsA:19.2","4rvjB-3mwsA:70.71"],["4RVJ_B_478B101_2","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",7,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;VAL A  32;ILE A  84","None","0.50A","4rvjB-3mwsA:19.2","4rvjB-3mwsA:70.71"],["4RVJ_B_478B101_2","3mws","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;VAL A  32;GLY A  49;ILE A  50;ILE A  84","None","0.48A","4rvjB-3mwsA:19.2","4rvjB-3mwsA:70.71"],["4RVJ_B_478B101_2","3pdx","Mus musculus","TYROSINE AMINOTRANSFERASE","PF00155(Aminotran_1_2)",5,"LEU A 331;GLY A 325;ALA A 326;VAL A  93;ILE A 330","None","0.93A","4rvjB-3pdxA:undetectable","4rvjB-3pdxA:16.09"],["4RVJ_B_478B101_2","3s52","Yersinia pestis","PUTATIVE FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN","PF01557(FAA_hydrolase)",5,"GLY A  97;ALA A  74;VAL A  19;ILE A  54;ILE A 186","None","0.92A","4rvjB-3s52A:undetectable","4rvjB-3s52A:20.55"],["4RVJ_B_478B101_2","3slz","Murine leukemia virus","GAG-PRO-POL POLYPROTEIN","PF00077(RVP)",6,"LEU A  30;ASP A  32;GLY A  34;ALA A  35;VAL A  39;GLY A  56","None;3TL A 126 (-2.4A);3TL A 126 (-3.1A);3TL A 126 ( 4.0A);None;3TL A 126 (-3.4A)","0.52A","4rvjB-3slzA:11.9","4rvjB-3slzA:25.95"],["4RVJ_B_478B101_2","3sm9","Homo sapiens","METABOTROPIC GLUTAMATE RECEPTOR 3","PF01094(ANF_receptor)",5,"LEU A  61;GLY A  67;ASP A  52;ILE A 121;ILE A  54","None","0.92A","4rvjB-3sm9A:undetectable","4rvjB-3sm9A:12.74"],["4RVJ_B_478B101_2","3snh","Homo sapiens","DYNAMIN-1","PF00169(PH);PF00350(Dynamin_N);PF01031(Dynamin_M);PF02212(GED)",6,"LEU A 170;GLY A 202;ALA A 173;VAL A 164;GLY A  38;ILE A 171","None","1.49A","4rvjB-3snhA:undetectable","4rvjB-3snhA:9.64"],["4RVJ_B_478B101_2","3t05","Staphylococcus aureus","PYRUVATE KINASE","PF00224(PK);PF00391(PEP-utilizers);PF02887(PK_C)",5,"GLY A 575;VAL A 487;GLY A 483;ILE A 482;ILE A 570","None","0.92A","4rvjB-3t05A:undetectable","4rvjB-3t05A:9.90"],["4RVJ_B_478B101_2","3t2y","Acidithiobacillus ferrooxidans","SULFIDE-QUINONE REDUCTASE, PUTATIVE","PF07992(Pyr_redox_2)",5,"LEU A   7;GLY A 106;ALA A 303;GLY A 281;ILE A 103","FAD A 500 (-4.7A);FAD A 500 (-3.1A);None;None;None","0.70A","4rvjB-3t2yA:undetectable","4rvjB-3t2yA:13.85"],["4RVJ_B_478B101_2","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","SO4 A 101 (-4.2A);017 A 201 (-2.6A);017 A 201 (-3.5A);017 A 201 (-3.5A);017 A 201 (-4.0A);017 A 201 (-3.3A)","1.38A","4rvjB-3t3cA:18.4","4rvjB-3t3cA:75.76"],["4RVJ_B_478B101_2","3t3c","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;VAL A  32;GLY A  49;ILE A  50","SO4 A 101 (-4.2A);017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-3.5A);017 A 201 (-4.2A);None;017 A 201 (-4.0A);017 A 201 (-3.3A)","0.41A","4rvjB-3t3cA:18.4","4rvjB-3t3cA:75.76"],["4RVJ_B_478B101_2","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None;017 A 201 (-2.6A);017 A 201 (-3.4A);017 A 201 (-3.3A);017 A 201 (-3.0A);017 A 201 (-3.3A)","1.26A","4rvjB-3ttpA:19.4","4rvjB-3ttpA:78.79"],["4RVJ_B_478B101_2","3ttp","Human immunodeficiency virus 1","HIV-1 PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;GLY A  49;ILE A  50;ILE A  84","None;017 A 201 (-2.6A);017 A 201 (-3.6A);017 A 201 (-3.4A);017 A 201 (-4.6A);017 A 201 (-3.0A);017 A 201 (-3.3A);017 A 201 (-4.7A)","0.56A","4rvjB-3ttpA:19.4","4rvjB-3ttpA:78.79"],["4RVJ_B_478B101_2","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None;017 A 202 ( 2.5A);017 A 201 (-3.4A);017 A 201 (-3.2A);017 A 202 (-2.9A);017 A 201 ( 3.5A)","1.29A","4rvjB-3u7sA:19.8","4rvjB-3u7sA:79.80"],["4RVJ_B_478B101_2","3u7s","Human immunodeficiency virus 1","POL POLYPROTEIN","PF00077(RVP)",7,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;GLY A  49;ILE A  50","None;017 A 202 ( 2.5A);017 A 201 ( 3.5A);017 A 201 (-3.4A);017 A 201 ( 4.0A);017 A 202 (-2.9A);017 A 201 ( 3.5A)","0.30A","4rvjB-3u7sA:19.8","4rvjB-3u7sA:79.80"],["4RVJ_B_478B101_2","3uzu","Burkholderia pseudomallei","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A","PF00398(RrnaAD)",5,"LEU A  88;GLY A  48;VAL A  56;GLY A 116;ILE A  45","None","0.80A","4rvjB-3uzuA:undetectable","4rvjB-3uzuA:17.20"],["4RVJ_B_478B101_2","4emk","Schizosaccharomyces pombe","U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5;U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7","PF01423(LSM)",5,"LEU A  10;GLY C  84;VAL C  88;GLY C  48;ILE C  49","None","0.89A","4rvjB-4emkA:undetectable","4rvjB-4emkA:20.91"],["4RVJ_B_478B101_2","4g6c","Burkholderia cenocepacia","BETA-HEXOSAMINIDASE 1","PF00933(Glyco_hydro_3)",5,"ASP A 128;GLY A 174;VAL A 136;ILE A 215;ILE A 137","None","0.83A","4rvjB-4g6cA:undetectable","4rvjB-4g6cA:15.72"],["4RVJ_B_478B101_2","4inj","Listeria monocytogenes","LMO1638 PROTEIN","PF02016(Peptidase_S66)",5,"LEU A 162;ALA A 309;GLY A 306;ILE A 305;ILE A 321","None","0.82A","4rvjB-4injA:undetectable","4rvjB-4injA:16.26"],["4RVJ_B_478B101_2","4ky0","Thermococcus kodakarensis","PROTON\/GLUTAMATE SYMPORTER, SDF FAMILY","PF00375(SDF)",5,"GLY A 210;ALA A 213;VAL A  41;GLY A  25;ILE A  45","None","0.91A","4rvjB-4ky0A:undetectable","4rvjB-4ky0A:14.78"],["4RVJ_B_478B101_2","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",5,"ALA A  28;ASP A  30;VAL A  32;GLY A  48;ILE A  84","RIT A 500 (-3.6A);RIT A 500 (-4.8A);None;RIT A 500 (-4.8A);RIT A 500 (-4.3A)","0.80A","4rvjB-4njvA:20.0","4rvjB-4njvA:98.99"],["4RVJ_B_478B101_2","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None;RIT A 500 (-2.4A);RIT A 500 (-3.6A);RIT A 500 (-3.2A);RIT A 500 (-3.4A);RIT A 500 (-4.3A)","1.28A","4rvjB-4njvA:20.0","4rvjB-4njvA:98.99"],["4RVJ_B_478B101_2","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",7,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;VAL A  32;ILE A  84","None;RIT A 500 (-2.4A);RIT A 500 (-3.9A);RIT A 500 (-3.6A);RIT A 500 (-4.8A);None;RIT A 500 (-4.3A)","0.46A","4rvjB-4njvA:20.0","4rvjB-4njvA:98.99"],["4RVJ_B_478B101_2","4njv","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;VAL A  32;GLY A  49;ILE A  50;ILE A  84","None;RIT A 500 (-2.4A);RIT A 500 (-3.9A);RIT A 500 (-3.6A);None;RIT A 500 (-3.4A);RIT A 500 (-4.3A);RIT A 500 (-4.3A)","0.40A","4rvjB-4njvA:20.0","4rvjB-4njvA:98.99"],["4RVJ_B_478B101_2","4nnm","Homo sapiens","TAX1-BINDING PROTEIN 3","PF00595(PDZ)",5,"LEU A 108;GLY A  71;ALA A  70;GLY A  65;ILE A  19","None","0.93A","4rvjB-4nnmA:undetectable","4rvjB-4nnmA:19.30"],["4RVJ_B_478B101_2","4nzr","Mycoplasma genitalium","PROTEIN M TD","no annotation",6,"LEU M 278;GLY M 270;ALA M 248;ASP M 250;ILE M 267;ILE M 251","None;None;None;None;GOL M 501 ( 4.3A);None","1.25A","4rvjB-4nzrM:undetectable","4rvjB-4nzrM:13.71"],["4RVJ_B_478B101_2","4oy7","Streptomyces coelicolor","PUTATIVE SECRETED CELLULOSE BINDING PROTEIN","PF03067(LPMO_10)",5,"LEU A 194;GLY A 131;ALA A 132;GLY A 229;ILE A 134","None","0.93A","4rvjB-4oy7A:undetectable","4rvjB-4oy7A:20.88"],["4RVJ_B_478B101_2","4pyr","Chromobacterium violaceum","PUTATIVE BRANCHED-CHAIN AMINO ACID ABC TRANSPORTER","PF04348(LppC)",5,"LEU A 166;VAL A  88;GLY A 107;ILE A 337;ILE A 146","None","0.68A","4rvjB-4pyrA:undetectable","4rvjB-4pyrA:14.33"],["4RVJ_B_478B101_2","4qi6","Crassicarpon hotsonii","CELLOBIOSE DEHYDROGENASE","PF00732(GMC_oxred_N);PF00734(CBM_1);PF05199(GMC_oxred_C);PF16010(CDH-cyt)",5,"LEU A 489;GLY A 481;ALA A 480;ILE A 477;ILE A 488","None;FAD A 902 (-3.6A);FAD A 902 (-3.9A);None;None","0.92A","4rvjB-4qi6A:undetectable","4rvjB-4qi6A:8.29"],["4RVJ_B_478B101_2","4ql6","Chlamydia trachomatis","CARBOXY-TERMINAL PROCESSING PROTEASE","PF00595(PDZ);PF03572(Peptidase_S41)",5,"LEU A 360;GLY A 400;VAL A 449;ILE A 459;ILE A 395","None","0.89A","4rvjB-4ql6A:undetectable","4rvjB-4ql6A:10.39"],["4RVJ_B_478B101_2","4qpn","Homo sapiens","PROTEIN-LYSINE METHYLTRANSFERASE METTL21B","PF10294(Methyltransf_16)",5,"LEU A 109;GLY A  83;ALA A  84;ILE A  80;ILE A 112","None;SAH A 301 (-3.6A);None;None;None","0.76A","4rvjB-4qpnA:undetectable","4rvjB-4qpnA:17.19"],["4RVJ_B_478B101_2","4xib","Homo sapiens","E3 UBIQUITIN-PROTEIN LIGASE MIB1","PF00569(ZZ);PF06701(MIB_HERC2)",6,"LEU A 215;GLY A 154;ALA A 155;ASP A 220;GLY A 223;ILE A 151","None","1.40A","4rvjB-4xibA:undetectable","4rvjB-4xibA:14.09"],["4RVJ_B_478B101_2","4xll","Toxoplasma gondii","DJ-1 FAMILY PROTEIN","PF01965(DJ-1_PfpI)",5,"LEU A 168;GLY A  29;ALA A  28;ILE A  22;ILE A 165","None","0.84A","4rvjB-4xllA:undetectable","4rvjB-4xllA:16.67"],["4RVJ_B_478B101_2","4xr9","Micromonospora echinospora","CALS8","PF00984(UDPG_MGDP_dh);PF03720(UDPG_MGDP_dh_C);PF03721(UDPG_MGDP_dh_N)",5,"ASP A 248;VAL A 249;GLY A 452;ILE A 451;ILE A 250","None","0.91A","4rvjB-4xr9A:undetectable","4rvjB-4xr9A:14.32"],["4RVJ_B_478B101_2","4ydf","Primate T-lymphotropic virus 1","HTLV-1 PROTEASE","PF00077(RVP)",7,"LEU A  30;ASP A  32;GLY A  34;ALA A  35;VAL A  39;GLY A  58;ILE A 100","None;4B1 A 201 (-2.9A);4B1 A 201 ( 4.6A);4B1 A 201 (-3.6A);None;4B1 A 201 (-3.4A);4B1 A 201 (-4.8A)","0.67A","4rvjB-4ydfA:13.4","4rvjB-4ydfA:33.06"],["4RVJ_B_478B101_2","5b18","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",5,"GLY A  27;ALA A  28;ASP A  30;GLY A  49;ILE A  84","None","0.86A","4rvjB-5b18A:18.4","4rvjB-5b18A:79.80"],["4RVJ_B_478B101_2","5cni","Homo sapiens","METABOTROPIC GLUTAMATE RECEPTOR 2","PF01094(ANF_receptor)",5,"LEU A  79;GLY A  85;ASP A  70;ILE A 140;ILE A  72","None","0.92A","4rvjB-5cniA:undetectable","4rvjB-5cniA:11.13"],["4RVJ_B_478B101_2","5cw2","Mycolicibacterium thermoresistibile","PUTATIVE EPOXIDE HYDROLASE EPHA","no annotation",5,"LEU C 315;GLY C  53;ALA C  52;ILE C  46;ILE C 312","None","0.77A","4rvjB-5cw2C:undetectable","4rvjB-5cw2C:15.52"],["4RVJ_B_478B101_2","5cw5","Camponotus floridanus","BRCA1\/BRCA2-CONTAINING COMPLEX SUBUNIT 3","PF01398(JAB)",5,"LEU A  79;VAL A  89;GLY A  33;ILE A  51;ILE A  36","None","0.91A","4rvjB-5cw5A:undetectable","4rvjB-5cw5A:16.41"],["4RVJ_B_478B101_2","5ej1","Rhodobacter sphaeroides","PUTATIVE CELLULOSE SYNTHASE","PF00535(Glycos_transf_2);PF03552(Cellulose_synt);PF07238(PilZ)",5,"LEU A 688;GLY A 614;VAL A 681;GLY A 655;ILE A 637","None;C2E A 919 (-3.4A);None;None;None","0.75A","4rvjB-5ej1A:undetectable","4rvjB-5ej1A:9.32"],["4RVJ_B_478B101_2","5ema","Rattus norvegicus","SORTING NEXIN-27","PF00595(PDZ)",5,"LEU A 130;GLY A  94;ALA A  93;GLY A  88;ILE A  46","None","0.89A","4rvjB-5emaA:undetectable","4rvjB-5emaA:24.78"],["4RVJ_B_478B101_2","5g5g","Escherichia coli","PUTATIVE XANTHINE DEHYDROGENASE YAGR MOLYBDENUM-BINDING SU SUBUNIT","PF00941(FAD_binding_5);PF03450(CO_deh_flav_C)",5,"LEU B 172;ALA B  94;ASP B 164;VAL B 167;ILE B 227","None;None;FAD B 321 (-3.9A);None;None","0.93A","4rvjB-5g5gB:undetectable","4rvjB-5g5gB:15.14"],["4RVJ_B_478B101_2","5g5g","Escherichia coli","PUTATIVE XANTHINE DEHYDROGENASE YAGT IRON-SULFUR-BINDING SUBUNIT","PF00111(Fer2);PF01799(Fer2_2)",5,"GLY A 211;ALA A 212;ASP A 154;GLY A 159;ILE A 216","None;None;None;FES A 230 (-4.2A);None","0.90A","4rvjB-5g5gA:undetectable","4rvjB-5g5gA:24.72"],["4RVJ_B_478B101_2","5ija","Thermococcus kodakarensis","HYDROGENASE-SPECIFIC MATURATION ENDOPEPTIDASE","PF01750(HycI)",6,"GLY A  17;ALA A  18;ASP A  57;GLY A  23;ILE A  25;ILE A 117","None","1.48A","4rvjB-5ijaA:undetectable","4rvjB-5ijaA:18.00"],["4RVJ_B_478B101_2","5it1","Streptomyces peucetius","PUTATIVE CYTOCHROME P450","PF00067(p450)",5,"ALA A 238;VAL A 150;GLY A 350;ILE A 349;ILE A 151","HEM A 401 (-3.1A);None;HEM A 401 ( 3.7A);HEM A 401 (-4.4A);None","0.92A","4rvjB-5it1A:undetectable","4rvjB-5it1A:13.32"],["4RVJ_B_478B101_2","5jxk","Porphyromonas endodontalis","ASP\/GLU-SPECIFIC DIPEPTIDYL-PEPTIDASE","PF10459(Peptidase_S46)",5,"GLY A 583;ALA A 594;VAL A 263;ILE A 689;ILE A 581","None","0.91A","4rvjB-5jxkA:undetectable","4rvjB-5jxkA:8.85"],["4RVJ_B_478B101_2","5kzn","Homo sapiens","METABOTROPIC GLUTAMATE RECEPTOR 2","PF01094(ANF_receptor);PF07562(NCD3G)",5,"LEU A  79;GLY A  85;ASP A  70;ILE A 140;ILE A  72","None","0.90A","4rvjB-5kznA:undetectable","4rvjB-5kznA:11.40"],["4RVJ_B_478B101_2","5n6m","Pseudomonas aeruginosa","APOLIPOPROTEIN N-ACYLTRANSFERASE","PF00795(CN_hydrolase)",5,"GLY A 324;ALA A 372;VAL A 400;ILE A 265;ILE A 377","None","0.88A","4rvjB-5n6mA:undetectable","4rvjB-5n6mA:9.94"],["4RVJ_B_478B101_2","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",6,"LEU A  23;ASP A  25;ALA A  28;ASP A  29;GLY A  49;ILE A  50","None","1.28A","4rvjB-5t2zA:19.6","4rvjB-5t2zA:85.86"],["4RVJ_B_478B101_2","5t2z","Human immunodeficiency virus 1","PROTEASE","PF00077(RVP)",9,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;VAL A  32;GLY A  49;ILE A  50;ILE A  84","None","0.51A","4rvjB-5t2zA:19.6","4rvjB-5t2zA:85.86"],["4RVJ_B_478B101_2","5tf0","Bacteroides intestinalis","GLYCOSYL HYDROLASE FAMILY 3 N-TERMINAL DOMAIN PROTEIN","PF00933(Glyco_hydro_3);PF01915(Glyco_hydro_3_C);PF14310(Fn3-like)",5,"GLY A 452;VAL A 461;GLY A 589;ILE A 588;ILE A 463","None","0.88A","4rvjB-5tf0A:undetectable","4rvjB-5tf0A:8.80"],["4RVJ_B_478B101_2","5z2e","Paenisporosarcina sp. TG-14","DIHYDRODIPICOLINATE REDUCTASE","no annotation",6,"GLY A 259;ALA A 124;VAL A  96;GLY A 242;ILE A 129;ILE A 122","None","1.48A","4rvjB-5z2eA:undetectable","4rvjB-5z2eA:21.57"],["4RVJ_B_478B101_2","6fiv","Feline immunodeficiency virus","RETROPEPSIN","PF00077(RVP)",5,"LEU A  28;ASP A  30;GLY A  32;ALA A  33;GLY A  58","None;3TL A 201 (-3.5A);3TL A 201 (-3.4A);3TL A 201 (-4.0A);3TL A 201 (-3.4A)","0.27A","4rvjB-6fivA:15.8","4rvjB-6fivA:31.30"],["4RVJ_B_478B101_2","6upj","Human immunodeficiency virus 2","HIV-2 PROTEASE","PF00077(RVP)",8,"LEU A  23;ASP A  25;GLY A  27;ALA A  28;ASP A  30;GLY A  49;ILE A  50;ILE A  84","None;NIU A 100 (-2.8A);NIU A 100 (-4.5A);NIU A 100 (-3.6A);None;NIU A 100 ( 3.8A);NIU A 100 (-3.9A);None","0.77A","4rvjB-6upjA:17.6","4rvjB-6upjA:47.47"]]