SIMILAR PATTERNS OF AMINO ACIDS FOR 4RVG_A_SAMA503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		5 TYR A 313
ILE A 307
ALA A 272
VAL A 298
ILE A 257
 None
COA  A3000 (-4.4A)
None
None
COA  A3000 (-4.0A)
 0.93A 4rvgA-1aj8A:
undetectable		 4rvgA-1aj8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 ILE A 119
GLY A 120
ASN A 122
PRO A 183
ILE A 190
 None
None
COA  A 901 (-4.7A)
None
None
 1.12A 4rvgA-1cqjA:
4.6		 4rvgA-1cqjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fb1 GTP CYCLOHYDROLASE I

(Homo sapiens) 		PF01227
(GTP_cyclohydroI) 		5 THR A 225
ILE A 189
VAL A 152
HIS A 153
ILE A 154
 None
 1.07A 4rvgA-1fb1A:
undetectable		 4rvgA-1fb1A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 PRO A 247
ALA A 246
ARG A 209
HIS A 173
ILE A 172
 None
PQQ  A 701 ( 4.2A)
None
None
None
 1.13A 4rvgA-1flgA:
undetectable		 4rvgA-1flgA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 ILE A 184
GLY A 189
PRO A 106
PHE A 187
VAL A 111
 None
 1.11A 4rvgA-1gqrA:
3.1		 4rvgA-1gqrA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 TYR A 342
ILE A 347
GLY A 346
ASN A 392
PHE A 334
 None
 1.12A 4rvgA-1iidA:
undetectable		 4rvgA-1iidA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1is7 GTP CYCLOHYDROLASE I

(Rattus
norvegicus) 		PF01227
(GTP_cyclohydroI) 		5 THR A 216
ILE A 180
VAL A 143
HIS A 144
ILE A 145
 None
 1.12A 4rvgA-1is7A:
undetectable		 4rvgA-1is7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 TYR A  36
THR A  26
ILE A  32
GLY A  33
ALA A  37
 None
 1.14A 4rvgA-1kb0A:
undetectable		 4rvgA-1kb0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 ILE A 563
ALA A 315
VAL A 504
HIS A 503
ILE A 501
 None
 0.92A 4rvgA-1kclA:
undetectable		 4rvgA-1kclA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 ILE A 134
GLY A 133
ALA A  70
VAL A  55
ILE A  93
 None
 1.04A 4rvgA-1kczA:
undetectable		 4rvgA-1kczA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyq SIROHEME
BIOSYNTHESIS PROTEIN
MET8

(Saccharomyces
cerevisiae) 		PF13241
(NAD_binding_7)
PF14823
(Sirohm_synth_C)
PF14824
(Sirohm_synth_M) 		5 ILE A  19
GLY A  20
PRO A  44
PHE A  93
ARG A  28
 None
NAD  A 800 (-3.5A)
NAD  A 800 (-3.7A)
None
None
 0.98A 4rvgA-1kyqA:
4.0		 4rvgA-1kyqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 TYR A 376
ILE A 327
GLY A 351
VAL A 223
ILE A 227
 None
 0.97A 4rvgA-1l1fA:
4.2		 4rvgA-1l1fA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llu ALCOHOL
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 156
ALA A 150
PHE A 304
VAL A 185
HIS A 184
 None
 1.14A 4rvgA-1lluA:
3.5		 4rvgA-1lluA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		5 THR A 110
ILE A 230
GLY A 229
ALA A  38
PHE A 225
 None
 1.09A 4rvgA-1mqqA:
undetectable		 4rvgA-1mqqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 162
GLY A 413
ALA A 418
VAL A 166
ILE A 120
 None
 0.89A 4rvgA-1qgdA:
3.4		 4rvgA-1qgdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 248
GLY A 249
PRO A  30
ALA A  15
VAL A 260
 TPP  A1671 (-4.4A)
None
None
None
None
 1.13A 4rvgA-1r9jA:
3.4		 4rvgA-1r9jA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE BETA
SUBUNIT

(Klebsiella
oxytoca) 		PF02288
(Dehydratase_MU) 		5 ILE B 168
GLY B 169
ALA B 176
ARG B 166
VAL B  91
 None
 1.07A 4rvgA-1uc4B:
undetectable		 4rvgA-1uc4B:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf3 HYPOTHETICAL PROTEIN
TT1561

(Thermus
thermophilus) 		PF14582
(Metallophos_3) 		5 GLY A 112
ALA A 136
ARG A  95
VAL A  69
ILE A  39
 None
 1.14A 4rvgA-1uf3A:
undetectable		 4rvgA-1uf3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya0 SMG-7 TRANSCRIPT
VARIANT 2

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		5 GLY A 186
ASN A 190
PRO A 220
ALA A 221
PHE A 217
 None
 1.13A 4rvgA-1ya0A:
undetectable		 4rvgA-1ya0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		5 GLY A 181
ASN A 179
ALA A  36
PHE A  31
ILE A 175
 None
 1.07A 4rvgA-2c5qA:
undetectable		 4rvgA-2c5qA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF00047
(ig) 		5 ILE A 170
GLY A 169
PHE A 162
VAL A 134
ILE A 172
 None
 1.15A 4rvgA-2e9wA:
undetectable		 4rvgA-2e9wA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		5 ILE A  99
GLY A  77
ALA A  31
VAL A 143
ILE A 152
 None
 1.14A 4rvgA-2eceA:
undetectable		 4rvgA-2eceA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN
GENOME POLYPROTEIN

(West Nile
virus;
West Nile virus) 		PF01002
(Flavi_NS2B)
PF00949
(Peptidase_S7) 		5 ILE A  60
GLY B 144
ASN B 143
VAL B 140
ILE B  98
 None
 1.13A 4rvgA-2fp7A:
undetectable		 4rvgA-2fp7A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		5 ILE A 309
ASN A 326
ARG A 398
VAL A 331
ILE A 647
 None
 1.07A 4rvgA-2g8gA:
undetectable		 4rvgA-2g8gA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Aquifex
aeolicus) 		PF03331
(LpxC) 		5 THR A  60
ILE A 244
GLY A 245
HIS A 238
ILE A 186
 None
None
None
ZN  A 601 ( 3.2A)
None
 0.99A 4rvgA-2go4A:
undetectable		 4rvgA-2go4A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Staphylococcus
aureus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 THR A 145
ILE A 172
GLY A 190
ALA A 236
ILE A   9
 None
 1.05A 4rvgA-2gqdA:
undetectable		 4rvgA-2gqdA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus) 		PF01784
(NIF3) 		5 ILE A  10
GLY A   7
ASN A  37
ALA A  35
VAL A  40
 None
 1.14A 4rvgA-2gx8A:
undetectable		 4rvgA-2gx8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		5 THR A 334
ILE A  30
PRO A 166
ARG A  35
VAL A  33
 None
 1.04A 4rvgA-2icyA:
undetectable		 4rvgA-2icyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb1 L-AMINO ACID OXIDASE

(Rhodococcus
opacus) 		PF01593
(Amino_oxidase) 		5 GLY A  20
PRO A  47
PHE A 246
VAL A  40
ILE A 250
 FAD  A1489 ( 4.6A)
None
None
None
None
 1.10A 4rvgA-2jb1A:
2.7		 4rvgA-2jb1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY

(Enterococcus
faecalis) 		PF04198
(Sugar-bind) 		5 ILE A 290
GLY A 178
PRO A 175
VAL A 208
ILE A 226
 None
 0.98A 4rvgA-2o0mA:
2.3		 4rvgA-2o0mA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
acinosa) 		PF00161
(RIP) 		5 THR A  61
ILE A  65
ALA A 169
HIS A  87
ILE A  88
 None
 1.02A 4rvgA-2q8wA:
undetectable		 4rvgA-2q8wA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 GLY A 134
ALA A 137
PHE A 166
VAL A 194
ILE A 168
 None
 1.08A 4rvgA-2rfqA:
undetectable		 4rvgA-2rfqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		5 ILE D 449
GLY D 405
PHE D 467
VAL D 424
ILE D 436
 None
 0.91A 4rvgA-2vnuD:
undetectable		 4rvgA-2vnuD:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		5 ILE J 449
GLY J 405
PHE J 467
VAL J 424
ILE J 436
 None
 0.92A 4rvgA-2wp8J:
undetectable		 4rvgA-2wp8J:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0m PROBABLE HISTONE
ACETYLTRANSFERASE
MYST1

(Homo sapiens) 		PF01853
(MOZ_SAS) 		5 TYR A 212
ILE A 184
GLY A 185
HIS A 297
ILE A 298
 None
 1.14A 4rvgA-2y0mA:
undetectable		 4rvgA-2y0mA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		5 TYR A 290
THR A 244
GLY A 250
ALA A 287
HIS A 300
 None
PMP  A 409 (-2.8A)
None
None
None
 1.06A 4rvgA-2zc0A:
4.2		 4rvgA-2zc0A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		5 ILE Y 403
GLY Y 406
ALA Y 232
VAL Y 271
ILE Y 274
 None
 1.12A 4rvgA-2zqpY:
undetectable		 4rvgA-2zqpY:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 ILE A 279
GLY A 280
ALA A 413
VAL A 421
ILE A 480
 None
 0.83A 4rvgA-3a1iA:
undetectable		 4rvgA-3a1iA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		5 TYR A 207
ILE A 120
ALA A 203
PHE A 213
ARG A 469
 None
 0.90A 4rvgA-3ayxA:
undetectable		 4rvgA-3ayxA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 ILE A 171
GLY A 172
PRO A 169
VAL A 175
ILE A 254
 None
 1.05A 4rvgA-3ccfA:
16.2		 4rvgA-3ccfA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzb PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Shewanella
putrefaciens) 		PF12680
(SnoaL_2) 		5 ILE A  96
GLY A  97
ASN A  82
PRO A 120
ALA A 118
 None
 1.02A 4rvgA-3gzbA:
undetectable		 4rvgA-3gzbA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		5 THR A 288
GLY A 367
PRO A 242
ALA A 245
PHE A 365
 None
OXY  A 492 ( 4.7A)
None
None
None
 1.01A 4rvgA-3kv6A:
undetectable		 4rvgA-3kv6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 ILE A 138
GLY A 135
PHE A 142
VAL A 124
ILE A 144
 None
 1.02A 4rvgA-3l01A:
3.2		 4rvgA-3l01A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm4 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus
jostii) 		PF00903
(Glyoxalase) 		5 THR A 178
ILE A 189
GLY A 190
VAL A 182
ILE A 292
 None
HPX  A 406 (-4.1A)
None
None
None
 1.00A 4rvgA-3lm4A:
undetectable		 4rvgA-3lm4A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp5 PUTATIVE CELL
SURFACE HYDROLASE

(Lactobacillus
plantarum) 		PF06028
(DUF915) 		5 ILE A  64
GLY A  65
ASN A  69
VAL A  41
ILE A  47
 None
 1.15A 4rvgA-3lp5A:
2.2		 4rvgA-3lp5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 TYR A 414
ILE A 216
GLY A 217
ASN A 219
ILE A 411
 None
 1.06A 4rvgA-3lp8A:
3.1		 4rvgA-3lp8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lza PUTATIVE SNOAL-LIKE
POLYKETIDE CYCLASE

(Shewanella
denitrificans) 		PF12680
(SnoaL_2) 		5 ILE A 100
GLY A 101
ASN A  86
PRO A 124
ALA A 122
 None
 1.01A 4rvgA-3lzaA:
undetectable		 4rvgA-3lzaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqt MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A 316
ILE A 105
GLY A 104
ASN A 284
VAL A  29
 None
 1.00A 4rvgA-3mqtA:
undetectable		 4rvgA-3mqtA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		5 TYR A 134
ILE A 101
VAL A  91
HIS A  90
ILE A  89
 IFP  A 542 (-4.9A)
None
None
IFP  A 542 (-3.4A)
None
 1.07A 4rvgA-3nm1A:
undetectable		 4rvgA-3nm1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A 321
ILE A 110
GLY A 109
ASN A 289
VAL A  34
 None
 1.02A 4rvgA-3nzgA:
undetectable		 4rvgA-3nzgA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		5 ILE A 539
ASN A 565
VAL A 523
HIS A 524
ILE A 525
 None
 1.04A 4rvgA-3ogzA:
undetectable		 4rvgA-3ogzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tca AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus) 		PF00169
(PH)
PF00788
(RA) 		5 ILE A 233
GLY A 370
ALA A 379
VAL A 386
ILE A 399
 None
 0.94A 4rvgA-3tcaA:
undetectable		 4rvgA-3tcaA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teo CARBON DISULFIDE
HYDROLASE

(Acidianus sp.
A1-3) 		PF00484
(Pro_CA) 		5 THR A  87
ILE A 157
GLY A 154
VAL A  63
ILE A  68
 None
 0.92A 4rvgA-3teoA:
undetectable		 4rvgA-3teoA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tni CYCLIN-T1

(Homo sapiens) 		PF00134
(Cyclin_N) 		5 ILE B 150
PRO B 153
ALA B 178
VAL B  64
HIS B  67
 None
 1.12A 4rvgA-3tniB:
undetectable		 4rvgA-3tniB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 ILE A 328
GLY A 329
ALA A 368
PHE A 379
VAL A 388
 None
 1.12A 4rvgA-3wfaA:
undetectable		 4rvgA-3wfaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		6 THR A 141
ILE A 422
GLY A 421
PRO A 169
ALA A 178
ILE A 284
 None
 1.24A 4rvgA-4a3rA:
undetectable		 4rvgA-4a3rA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amq L544

(Acanthamoeba
polyphaga
mimivirus) 		no annotation 5 TYR A 186
THR A 266
ILE A  45
GLY A 189
ILE A  42
 None
 0.85A 4rvgA-4amqA:
undetectable		 4rvgA-4amqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 ILE A  26
GLY A  23
PRO A  50
ALA A  49
VAL A  15
 None
 0.99A 4rvgA-4avyA:
5.8		 4rvgA-4avyA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e2z TCAB9

(Micromonospora
chalcea) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		6 ILE A 112
GLY A 113
ASN A 115
PRO A 135
PHE A 155
ILE A 182
 SAH  A 503 (-4.5A)
SAH  A 503 (-3.4A)
SAH  A 503 (-4.3A)
SAH  A 503 (-3.8A)
None
SAH  A 503 (-4.4A)
 0.31A 4rvgA-4e2zA:
54.1		 4rvgA-4e2zA:
39.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvg AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus) 		PF00169
(PH)
PF00788
(RA) 		5 ILE B 233
GLY B 370
ALA B 379
VAL B 386
ILE B 399
 None
 0.87A 4rvgA-4kvgB:
undetectable		 4rvgA-4kvgB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1

(Homo sapiens) 		PF00400
(WD40) 		5 GLY A 460
ALA A 418
VAL A 466
HIS A 467
ILE A 468
 None
 1.15A 4rvgA-4lg9A:
undetectable		 4rvgA-4lg9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 ILE A  45
GLY A  40
ALA A  37
VAL A  16
ILE A  18
 None
 1.03A 4rvgA-4lmpA:
6.7		 4rvgA-4lmpA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		5 ILE A  61
ASN A 138
ARG A  70
VAL A 140
ILE A 168
 None
 1.15A 4rvgA-4m0dA:
2.7		 4rvgA-4m0dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF14262
(Cthe_2159) 		5 ILE A 173
GLY A 172
ALA A 212
VAL A 165
ILE A 186
 None
 1.00A 4rvgA-4phbA:
undetectable		 4rvgA-4phbA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaf LIPOCALIN-1

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A 100
ILE A  80
GLY A 103
HIS A  84
ILE A  83
 None
None
None
None
OMA  A 201 ( 4.9A)
 1.13A 4rvgA-4qafA:
undetectable		 4rvgA-4qafA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn0 ENDONUCLEASE G,
MITOCHONDRIAL

(Caenorhabditis
elegans) 		PF01223
(Endonuclease_NS) 		5 TYR A 202
ALA A 241
PHE A  86
HIS A 103
ILE A  69
 None
 1.14A 4rvgA-4qn0A:
undetectable		 4rvgA-4qn0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		5 ILE A 922
GLY A 933
ALA A 880
VAL A 920
ILE A 633
 None
 1.03A 4rvgA-4ra7A:
undetectable		 4rvgA-4ra7A:
25.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		6 THR A  81
ILE A 113
GLY A 114
ALA A 141
PHE A 156
ARG A 177
 SAH  A 502 (-2.8A)
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
None
None
SAH  A 502 (-3.4A)
 1.22A 4rvgA-4rvhA:
68.7		 4rvgA-4rvhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		12 TYR A  74
THR A  81
ILE A 113
GLY A 114
ASN A 116
PRO A 136
ALA A 137
PHE A 156
ARG A 177
VAL A 179
HIS A 182
ILE A 183
 SAH  A 502 (-3.6A)
SAH  A 502 (-2.8A)
SAH  A 502 (-4.7A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.0A)
SAH  A 502 (-4.0A)
SAH  A 502 ( 3.8A)
None
SAH  A 502 (-3.4A)
SAH  A 502 (-4.2A)
3YN  A 503 (-3.9A)
SAH  A 502 (-4.2A)
 0.12A 4rvgA-4rvhA:
68.7		 4rvgA-4rvhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		5 ILE Q 524
GLY Q  37
ASN Q  36
VAL Q  34
ILE Q  16
 None
 0.89A 4rvgA-4upeQ:
undetectable		 4rvgA-4upeQ:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A   9
GLY A  17
ALA A 241
HIS A  22
ILE A  24
 None
 1.08A 4rvgA-4uulA:
4.5		 4rvgA-4uulA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 ILE A 182
GLY A 187
PRO A 104
PHE A 185
VAL A 109
 None
None
EDO  A1022 (-4.6A)
None
None
 1.09A 4rvgA-4xiiA:
2.7		 4rvgA-4xiiA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		5 ILE A 394
ASN A 416
PRO A 422
VAL A 294
ILE A 310
 None
 1.10A 4rvgA-4xpzA:
undetectable		 4rvgA-4xpzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aov GLYOXYLATE REDUCTASE

(Pyrococcus
furiosus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 THR A  96
ILE A  57
ASN A  95
VAL A  71
ILE A  91
 None
 1.14A 4rvgA-5aovA:
6.6		 4rvgA-5aovA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j NMDA GLUTAMATE
RECEPTOR SUBUNIT

(Xenopus laevis) 		PF01094
(ANF_receptor) 		5 THR A 140
ILE A  29
PRO A 117
VAL A 309
ILE A 313
 None
 0.92A 4rvgA-5b3jA:
5.5		 4rvgA-5b3jA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwi GLYCOSIDE HYDROLASE
FAMILY 79

(Burkholderia
pseudomallei) 		PF12891
(Glyco_hydro_44) 		5 ILE A  26
GLY A 332
PHE A  30
ARG A 334
VAL A 352
 None
GOL  A 501 ( 4.9A)
None
None
None
 1.02A 4rvgA-5bwiA:
undetectable		 4rvgA-5bwiA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diz PROTEINACEOUS RNASE
P 2

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		5 THR A 453
ILE A 485
GLY A 212
PHE A 495
VAL A 484
 None
 1.14A 4rvgA-5dizA:
undetectable		 4rvgA-5dizA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 THR C 171
ILE C 208
GLY C 200
ALA C 247
ILE C 212
 None
None
KCX  C 220 ( 3.2A)
KCX  C 220 ( 4.0A)
None
 1.03A 4rvgA-5fseC:
undetectable		 4rvgA-5fseC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		5 GLY A 199
ASN A 197
ALA A  68
VAL A 155
ILE A 153
 None
 1.00A 4rvgA-5gkxA:
2.9		 4rvgA-5gkxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idk GENOME
POLYPROTEIN,SERINE
PROTEASE SUBUNIT
NS2B, SERINE
PROTEASE NS3

(West Nile virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 ILE A  60
GLY A1144
ASN A1143
VAL A1140
ILE A1098
 None
 1.15A 4rvgA-5idkA:
undetectable		 4rvgA-5idkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3u PROTEIN KINASE A

(Toxoplasma
gondii) 		PF00027
(cNMP_binding) 		5 ILE A 326
GLY A 353
VAL A 285
HIS A 286
ILE A 287
 None
 0.90A 4rvgA-5j3uA:
undetectable		 4rvgA-5j3uA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 ILE A 510
GLY A 410
ASN A 435
ARG A 411
ILE A 474
 None
 1.09A 4rvgA-5j84A:
undetectable		 4rvgA-5j84A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9o HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 THR F 272
ILE F 267
PRO F  58
ALA F  57
ILE F  66
 None
 1.15A 4rvgA-5k9oF:
undetectable		 4rvgA-5k9oF:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2d SURFACE-ASSOCIATED
PROTEIN CSHA

(Streptococcus
gordonii) 		no annotation 5 ILE A 154
GLY A 226
PRO A 213
VAL A 224
ILE A  50
 None
 1.12A 4rvgA-5l2dA:
undetectable		 4rvgA-5l2dA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lk7 VP1

(Slow bee
paralysis virus) 		PF08762
(CRPV_capsid) 		5 ILE A 202
GLY A 203
ASN A  59
VAL A 118
ILE A 163
 None
 1.11A 4rvgA-5lk7A:
undetectable		 4rvgA-5lk7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 THR A 574
ILE A 570
ASN A 546
VAL A 598
ILE A 600
 None
 1.07A 4rvgA-5n8pA:
undetectable		 4rvgA-5n8pA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 THR A 574
ILE A 570
ASN A 546
VAL A 598
ILE A 600
 None
 1.07A 4rvgA-5n97A:
undetectable		 4rvgA-5n97A:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 GLY A 322
ALA A 325
ARG A 319
VAL A 343
ILE A 338
 None
 0.90A 4rvgA-5t67A:
54.1		 4rvgA-5t67A:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 ILE A 112
GLY A 113
ASN A 115
ALA A 140
PHE A 155
 SAH  A 502 (-4.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.3A)
None
None
 0.84A 4rvgA-5t67A:
54.1		 4rvgA-5t67A:
39.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		7 ILE A 112
GLY A 113
ASN A 115
PRO A 135
PHE A 155
HIS A 181
ILE A 182
 SAH  A 502 (-4.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-4.3A)
SAH  A 502 (-3.9A)
None
JHZ  A 503 (-3.9A)
SAH  A 502 (-4.4A)
 0.36A 4rvgA-5t67A:
54.1		 4rvgA-5t67A:
39.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 ILE A  35
ALA A 219
ARG A  43
VAL A  47
ILE A  51
 None
 1.12A 4rvgA-5u2wA:
5.8		 4rvgA-5u2wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyr BACTERIOPHYTOCHROME

(Xanthomonas
campestris) 		no annotation 5 ILE A 409
GLY A 425
ALA A 358
VAL A 406
HIS A 405
 None
 1.12A 4rvgA-5uyrA:
undetectable		 4rvgA-5uyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ILE 7 121
ALA 7  65
ARG 7 199
VAL 7  78
ILE 7  80
 None
 1.14A 4rvgA-5v8f7:
undetectable		 4rvgA-5v8f7:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
PF01801
(Cytomega_gL) 		5 THR A  69
ASN A  79
ARG B 207
VAL B 191
ILE B 173
 None
 0.98A 4rvgA-5vocA:
undetectable		 4rvgA-5vocA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B 158
GLY B 159
PHE B 414
VAL B 115
ILE B  46
 None
 1.05A 4rvgA-5xogB:
undetectable		 4rvgA-5xogB:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 5 ILE A 344
GLY A 349
PRO A 267
PHE A 347
VAL A 272
 None
 1.09A 4rvgA-5ydjA:
undetectable		 4rvgA-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an0 HISTIDINOL
DEHYDROGENASE

(Elizabethkingia
anophelis) 		PF00815
(Histidinol_dh) 		5 TYR A 180
THR A 192
ILE A 123
ALA A 182
ILE A 176
 None
 1.07A 4rvgA-6an0A:
3.5		 4rvgA-6an0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2v SORB

(Sorangium
cellulosum) 		no annotation 5 TYR A  42
ALA A  46
VAL A  99
HIS A 100
ILE A  66
 None
 1.04A 4rvgA-6b2vA:
undetectable		 4rvgA-6b2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckt 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E

(Legionella
pneumophila) 		no annotation 5 ILE A 164
GLY A 147
ASN A 129
ALA A 115
ILE A 158
 None
None
EDO  A 302 (-3.2A)
None
None
 1.14A 4rvgA-6cktA:
undetectable		 4rvgA-6cktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkx ACETYL XYLAN
ESTERASE

(metagenome) 		no annotation 5 THR C 161
GLY C 189
PRO C 206
ALA C 204
VAL C 256
 None
 1.14A 4rvgA-6fkxC:
undetectable		 4rvgA-6fkxC:
undetectable