SIMILAR PATTERNS OF AMINO ACIDS FOR 4RVD_A_ACTA503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 ALA A 331
LYS A 332
TYR A 419
GLU A 417
 None
 1.23A 4rvdA-1ua4A:
3.4		 4rvdA-1ua4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gae PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL) 		4 ALA A 536
LYS A 533
TYR A 556
GLU A 559
 None
 1.41A 4rvdA-3gaeA:
0.0		 4rvdA-3gaeA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ALA E 612
LYS E 613
TYR E 690
GLU E 834
 None
 1.14A 4rvdA-4a0lE:
0.0		 4rvdA-4a0lE:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG

(Homo sapiens) 		PF00515
(TPR_1)
PF12895
(ANAPC3)
PF13181
(TPR_8) 		4 ALA A 557
LYS A 554
TYR A 545
GLU A 525
 None
 1.41A 4rvdA-4rg6A:
0.0		 4rvdA-4rg6A:
19.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 ALA A 373
LYS A 374
TYR A 381
GLU A 396
 CSO  A 349 ( 3.9A)
None
None
None
 0.16A 4rvdA-4rvhA:
67.3		 4rvdA-4rvhA:
100.00