SIMILAR PATTERNS OF AMINO ACIDS FOR 4RTS_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermococcus
litoralis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 GLY A  69
ILE A 358
ASN A 357
ASP A 139
PRO A  66
None
1.22A 4rtsA-1bvuA:
0.3
4rtsA-1bvuA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri)
PF01804
(Penicil_amidase)
5 TRP B  65
GLY B  66
GLY B  58
ILE B  35
ASP B 484
None
1.21A 4rtsA-1cp9B:
0.0
4rtsA-1cp9B:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii)
PF05175
(MTS)
5 GLY A  65
ASP A  84
ILE A  85
ASN A  86
PRO A 131
None
0.70A 4rtsA-1dusA:
13.2
4rtsA-1dusA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1euz GLUTAMATE
DEHYDROGENASE


(Thermococcus
profundus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 GLY A  70
ILE A 359
ASN A 358
ASP A 140
PRO A  67
SO4  A 601 (-3.3A)
None
None
None
None
1.13A 4rtsA-1euzA:
1.0
4rtsA-1euzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiw BETA-ACROSIN HEAVY
CHAIN
BETA-ACROSIN LIGHT
CHAIN


(Ovis aries;
Ovis aries)
PF00089
(Trypsin)
no annotation
5 GLY L   7
GLY L  10
ASN A 202
SER A 202
PRO A 253
None
1.22A 4rtsA-1fiwL:
undetectable
4rtsA-1fiwL:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE


(Saccharomyces
cerevisiae)
PF00162
(PGK)
5 PHE A 114
ASP A  90
ILE A  88
ASN A  89
TYR A 392
None
0.95A 4rtsA-1fw8A:
undetectable
4rtsA-1fw8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA


(Moraxella bovis)
PF01555
(N6_N4_Mtase)
7 PHE A 220
GLY A 222
ASP A 241
ASN A 243
ASP A  30
PRO A  32
TYR A  33
SAM  A 500 (-4.6A)
SAM  A 500 (-3.2A)
SAM  A 500 (-2.9A)
None
SAM  A 500 (-3.7A)
None
None
0.91A 4rtsA-1g60A:
2.2
4rtsA-1g60A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE


(Pyrococcus
furiosus)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 GLY A  69
ILE A 359
ASN A 358
ASP A 139
PRO A  66
None
1.15A 4rtsA-1gtmA:
undetectable
4rtsA-1gtmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B


(Escherichia
coli)
PF02527
(GidB)
5 GLY A  99
GLY A  75
ILE A  81
SER A  84
PRO A 119
None
1.18A 4rtsA-1jsxA:
9.5
4rtsA-1jsxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5s PENICILLIN G ACYLASE
BETA SUBUNIT


(Escherichia
coli)
PF01804
(Penicil_amidase)
5 TRP B  65
GLY B  66
GLY B  58
ILE B  35
ASP B 484
None
1.15A 4rtsA-1k5sB:
undetectable
4rtsA-1k5sB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI


(Rhodobacter
sphaeroides)
PF01555
(N6_N4_Mtase)
5 PHE A 250
GLY A 252
ASP A 271
ASP A  65
PRO A  67
SAM  A 401 (-4.7A)
SAM  A 401 (-3.3A)
SAM  A 401 (-2.9A)
SAM  A 401 (-3.3A)
SAM  A 401 (-4.3A)
0.64A 4rtsA-1nw5A:
2.3
4rtsA-1nw5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqw POLYKETIDE SYNTHASE

(Mycobacterium
tuberculosis)
PF00107
(ADH_zinc_N)
5 GLY A 107
GLY A 131
ILE A 134
SER A  29
TYR A  67
None
1.13A 4rtsA-1pqwA:
5.7
4rtsA-1pqwA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Leishmania
mexicana)
PF00342
(PGI)
5 TRP A 188
GLY A 190
PHE A 295
ILE A 310
ASN A 314
None
1.20A 4rtsA-1q50A:
undetectable
4rtsA-1q50A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE


(Saccharomyces
cerevisiae)
PF00162
(PGK)
5 PHE A 185
ASP A 161
ILE A 159
ASN A 160
TYR A  48
None
1.04A 4rtsA-1qpgA:
undetectable
4rtsA-1qpgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvb BETA-GLYCOSIDASE

(Thermosphaera
aggregans)
PF00232
(Glyco_hydro_1)
5 GLY A 388
GLY A 441
ASP A 428
TYR A 430
TYR A 321
None
1.22A 4rtsA-1qvbA:
undetectable
4rtsA-1qvbA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ud3 AMYLASE

(Bacillus sp.
KSM-K38)
PF00128
(Alpha-amylase)
PF09154
(DUF1939)
5 GLY A  88
ILE A  95
ASN A  93
TYR A  98
ASP A 224
None
1.07A 4rtsA-1ud3A:
undetectable
4rtsA-1ud3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwi BETA-GALACTOSIDASE

(Sulfolobus
solfataricus)
PF00232
(Glyco_hydro_1)
5 GLY A 389
GLY A 442
ASP A 429
TYR A 431
TYR A 322
None
1.25A 4rtsA-1uwiA:
undetectable
4rtsA-1uwiA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE


(Escherichia
virus T4)
PF02086
(MethyltransfD12)
5 GLY A   9
GLY A  34
ASP A  50
PRO A 173
TYR A 174
None
SAH  A 401 (-3.2A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.0A)
None
0.75A 4rtsA-1yfjA:
19.1
4rtsA-1yfjA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE


(Escherichia
virus T4)
PF02086
(MethyltransfD12)
7 GLY A   9
PHE A  32
GLY A  34
ASP A  50
ILE A  51
ASP A 171
PRO A 173
None
SAH  A 401 (-4.2A)
SAH  A 401 (-3.2A)
SAH  A 401 (-2.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.8A)
SAH  A 401 (-4.0A)
0.42A 4rtsA-1yfjA:
19.1
4rtsA-1yfjA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915


(Pyrococcus
horikoshii)
PF01472
(PUA)
PF10672
(Methyltrans_SAM)
5 PHE A 225
ASP A 247
SER A 275
ASP A 296
PRO A 298
None
0.45A 4rtsA-2as0A:
11.3
4rtsA-2as0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli)
PF01370
(Epimerase)
5 PHE A 326
GLY A 325
ASP A 499
ASN A 500
SER A 509
None
1.25A 4rtsA-2bllA:
2.4
4rtsA-2bllA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)


(Streptococcus
pneumoniae)
PF02086
(MethyltransfD12)
9 TRP A  17
GLY A  19
PHE A  43
GLY A  45
ASP A  62
ASN A  64
ASP A 194
PRO A 196
TYR A 197
SAM  A 300 (-4.3A)
SAM  A 300 (-4.4A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.6A)
SAM  A 300 (-2.8A)
None
SAM  A 300 (-3.7A)
SAM  A 300 ( 4.1A)
None
0.74A 4rtsA-2dpmA:
9.6
4rtsA-2dpmA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpm PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1)


(Streptococcus
pneumoniae)
PF02086
(MethyltransfD12)
7 TRP A  17
GLY A  20
PHE A  43
GLY A  45
ASP A  62
ASN A  64
ASP A 194
SAM  A 300 (-4.3A)
SAM  A 300 (-3.3A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.6A)
SAM  A 300 (-2.8A)
None
SAM  A 300 (-3.7A)
1.02A 4rtsA-2dpmA:
9.6
4rtsA-2dpmA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1


(Bos taurus)
PF00115
(COX1)
5 ASP A 227
ILE A 229
TYR A 231
ASP A 221
PRO A 131
None
1.20A 4rtsA-2eijA:
undetectable
4rtsA-2eijA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes)
PF03602
(Cons_hypoth95)
5 PHE A  49
GLY A  51
ASN A  73
ASP A 117
PRO A 119
None
0.88A 4rtsA-2esrA:
10.9
4rtsA-2esrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE


(Aquifex
aeolicus)
PF02153
(PDH)
5 GLY A  39
ASP A  62
ILE A  63
ASN A  64
PRO A 100
NAD  A3686 (-3.3A)
NAD  A3686 (-2.8A)
NAD  A3686 (-3.9A)
None
NAD  A3686 (-4.5A)
0.99A 4rtsA-2g5cA:
5.4
4rtsA-2g5cA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE


(Agrobacterium
fabrum)
PF10672
(Methyltrans_SAM)
5 PHE A 140
GLY A 141
ASP A 161
ASP A 211
PRO A 213
SAM  A1001 (-4.4A)
None
SAM  A1001 (-2.9A)
SAM  A1001 (-2.8A)
SAM  A1001 (-3.2A)
1.14A 4rtsA-2igtA:
9.7
4rtsA-2igtA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE


(Agrobacterium
fabrum)
PF10672
(Methyltrans_SAM)
5 PHE A 140
GLY A 141
ASP A 161
ASP A 211
TYR A 253
SAM  A1001 (-4.4A)
None
SAM  A1001 (-2.9A)
SAM  A1001 (-2.8A)
SAM  A1001 (-4.7A)
1.26A 4rtsA-2igtA:
9.7
4rtsA-2igtA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780


(Pyrococcus
abyssi)
PF05958
(tRNA_U5-meth_tr)
6 GLY A 280
ASP A 299
ASN A 301
SER A 325
ASP A 340
PRO A 342
SAH  A1406 (-3.4A)
SAH  A1406 (-2.8A)
None
SAH  A1406 (-4.0A)
SAH  A1406 (-3.8A)
SAH  A1406 (-4.1A)
0.82A 4rtsA-2jjqA:
10.7
4rtsA-2jjqA:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxf PUTATIVE DIMETAL
PHOSPHATASE


(Danio rerio)
PF00149
(Metallophos)
5 GLY A 270
GLY A 264
ASP A  13
ILE A 287
ASP A 266
None
None
ZN  A 401 (-3.1A)
None
None
1.26A 4rtsA-2nxfA:
undetectable
4rtsA-2nxfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLY A 547
GLY A 476
ASP A 447
ILE A 471
ASN A 473
None
MG  A1001 ( 4.1A)
MG  A1001 ( 2.8A)
None
None
1.25A 4rtsA-2q27A:
2.7
4rtsA-2q27A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt2 REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX


(Bacillus
subtilis)
PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N)
5 GLY A  94
ASP A 118
ILE A 119
ASN A 120
PRO A 154
NAD  A1210 (-3.3A)
NAD  A1210 (-2.8A)
NAD  A1210 (-4.0A)
None
NAD  A1210 (-4.1A)
0.94A 4rtsA-2vt2A:
undetectable
4rtsA-2vt2A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus)
PF05711
(TylF)
5 GLY A 126
GLY A 197
ASP A 196
ILE A  66
ASP A 122
SAH  A 301 (-3.0A)
EDO  A 551 ( 3.7A)
SAH  A 301 ( 3.5A)
SAH  A 301 (-4.1A)
SAH  A 301 (-2.7A)
1.15A 4rtsA-2wk1A:
undetectable
4rtsA-2wk1A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Mycobacterium
tuberculosis)
PF00342
(PGI)
5 TRP A 141
GLY A 143
PHE A 242
ILE A 257
ASN A 261
None
1.19A 4rtsA-2wu8A:
undetectable
4rtsA-2wu8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yz1 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE
SUBSTRATE 1


(Mus musculus)
PF07686
(V-set)
5 GLY A 101
PHE A  98
GLY A  38
SER A 111
ASP A 106
None
1.13A 4rtsA-2yz1A:
undetectable
4rtsA-2yz1A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883


(Methanocaldococcus
jannaschii)
PF02475
(Met_10)
5 PHE A 203
GLY A 205
ASP A 223
ILE A 224
ASN A 225
ADN  A 401 (-4.9A)
ADN  A 401 ( 4.0A)
ADN  A 401 (-2.6A)
ADN  A 401 (-3.7A)
ADN  A 401 (-4.9A)
0.56A 4rtsA-3ay0A:
11.4
4rtsA-3ay0A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE


(Rhodobacter
sphaeroides)
PF04952
(AstE_AspA)
5 GLY A 151
ASP A 112
ILE A 113
ASN A 114
TYR A  66
None
1.24A 4rtsA-3cdxA:
undetectable
4rtsA-3cdxA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp7 ALKALINE SERINE
PROTEASE AL20


(Nesterenkonia
aethiopica)
PF13365
(Trypsin_2)
5 GLY A  64
GLY A 138
SER A 143
TYR A 128
PRO A   3
None
1.16A 4rtsA-3cp7A:
undetectable
4rtsA-3cp7A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dli METHYLTRANSFERASE

(Archaeoglobus
fulgidus)
PF13489
(Methyltransf_23)
5 PHE A 351
GLY A 292
ASP A 311
ILE A 312
ASN A 313
None
0.82A 4rtsA-3dliA:
10.4
4rtsA-3dliA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG


(Homo sapiens)
PF09445
(Methyltransf_15)
5 PHE A 698
GLY A 700
ASP A 719
ILE A 720
PRO A 765
ADP  A   3 (-4.5A)
ADP  A   3 (-3.5A)
ADP  A   3 (-2.9A)
ADP  A   3 (-3.8A)
ADP  A   3 (-3.3A)
0.44A 4rtsA-3egiA:
11.5
4rtsA-3egiA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN


(Geobacillus
kaustophilus)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
5 PHE A1085
ASP A1086
ILE A1005
PRO A 387
TYR A 390
None
1.27A 4rtsA-3f2bA:
undetectable
4rtsA-3f2bA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG


(Homo sapiens)
PF09445
(Methyltransf_15)
5 PHE A 698
GLY A 700
ASP A 719
ILE A 720
PRO A 765
SAH  A 854 (-4.3A)
SAH  A 854 (-3.3A)
SAH  A 854 (-2.9A)
SAH  A 854 (-3.6A)
SAH  A 854 (-3.8A)
0.50A 4rtsA-3gdhA:
12.3
4rtsA-3gdhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggg PREPHENATE
DEHYDROGENASE


(Aquifex
aeolicus)
no annotation 5 GLY D  39
ASP D  62
ILE D  63
ASN D  64
PRO D 100
NAD  D6686 (-3.3A)
NAD  D6686 (-2.9A)
NAD  D6686 (-4.0A)
None
NAD  D6686 (-4.6A)
0.95A 4rtsA-3gggD:
undetectable
4rtsA-3gggD:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE


(Lactobacillus
delbrueckii)
PF06325
(PrmA)
5 GLY A 158
GLY A 186
ASP A 206
ILE A 207
SER A 233
None
None
GOL  A 322 (-3.5A)
GOL  A 322 (-4.1A)
GOL  A 322 ( 4.3A)
0.63A 4rtsA-3grzA:
10.9
4rtsA-3grzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjb GLUCOSE-6-PHOSPHATE
ISOMERASE


(Vibrio cholerae)
PF00342
(PGI)
5 TRP A 140
GLY A 142
PHE A 241
ILE A 256
ASN A 260
None
1.17A 4rtsA-3hjbA:
undetectable
4rtsA-3hjbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE


(Bacillus
anthracis)
PF00342
(PGI)
5 GLY A 242
PHE A 400
GLY A 237
PRO A 250
TYR A 252
None
1.17A 4rtsA-3ifsA:
undetectable
4rtsA-3ifsA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N)
5 GLY 1 489
GLY 1 530
ILE 1 266
ASN 1 261
SER 1 267
None
1.05A 4rtsA-3izq1:
undetectable
4rtsA-3izq1:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbl NLR FAMILY CARD
DOMAIN-CONTAINING
PROTEIN 4


(Mus musculus)
no annotation 5 GLY K1004
PHE K 972
GLY K 946
ILE K 924
ASP K 971
None
1.25A 4rtsA-3jblK:
undetectable
4rtsA-3jblK:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile)
PF01170
(UPF0020)
PF02926
(THUMP)
5 GLY A 202
ASP A 261
ILE A 262
PRO A 307
TYR A 308
GTP  A 383 (-2.6A)
GTP  A 383 (-3.0A)
GTP  A 383 (-4.2A)
GTP  A 383 (-3.7A)
None
0.59A 4rtsA-3lduA:
10.9
4rtsA-3lduA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF00342
(PGI)
5 TRP A 139
GLY A 141
PHE A 240
ILE A 255
TYR A 142
None
1.26A 4rtsA-3nbuA:
undetectable
4rtsA-3nbuA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3v PHOSPHOGLYCERATE
KINASE


(Campylobacter
jejuni)
PF00162
(PGK)
5 PHE A 173
ASP A 145
ILE A 143
ASN A 144
TYR A  48
None
0.98A 4rtsA-3q3vA:
3.5
4rtsA-3q3vA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE


(Entamoeba
histolytica)
PF00145
(DNA_methylase)
6 PHE A  12
GLY A  14
ASP A  37
ILE A  38
ASN A  39
PRO A  80
SAH  A 323 (-4.4A)
SAH  A 323 (-3.6A)
SAH  A 323 (-2.9A)
SAH  A 323 (-4.0A)
SAH  A 323 (-4.8A)
SAH  A 323 (-4.4A)
0.87A 4rtsA-3qv2A:
6.1
4rtsA-3qv2A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgz HYDROXYACID OXIDASE
2


(Rattus
norvegicus)
PF01070
(FMN_dh)
5 PHE A 299
GLY A 301
ILE A 298
TYR A 276
TYR A 102
None
FMN  A 401 (-3.4A)
None
None
None
1.15A 4rtsA-3sgzA:
undetectable
4rtsA-3sgzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubg NEURAL-CADHERIN

(Drosophila
melanogaster)
PF00028
(Cadherin)
5 GLY A 625
ASP A 622
ILE A 578
ASN A 577
TYR A 542
None
CA  A 901 (-3.5A)
None
None
None
1.17A 4rtsA-3ubgA:
undetectable
4rtsA-3ubgA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubh NEURAL-CADHERIN

(Drosophila
melanogaster)
PF00028
(Cadherin)
5 GLY A 625
ASP A 622
ILE A 578
ASN A 577
TYR A 542
None
CA  A 854 (-3.3A)
None
None
None
1.13A 4rtsA-3ubhA:
undetectable
4rtsA-3ubhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo)
PF00082
(Peptidase_S8)
5 GLY A 164
GLY A 266
ASP A 268
ILE A 134
PRO A 159
None
1.25A 4rtsA-3vtaA:
undetectable
4rtsA-3vtaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgh REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX


(Thermoanaerobacter
ethanolicus)
PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N)
5 GLY A  93
ASP A 117
ILE A 118
ASN A 119
PRO A 155
NAI  A 301 (-3.3A)
NAI  A 301 (-2.8A)
NAI  A 301 (-4.1A)
None
NAI  A 301 (-4.3A)
0.85A 4rtsA-3wghA:
undetectable
4rtsA-3wghA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus)
PF00232
(Glyco_hydro_1)
5 GLY A 374
GLY A 427
ASP A 414
TYR A 416
TYR A 307
None
1.21A 4rtsA-3wq8A:
undetectable
4rtsA-3wq8A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum)
PF00703
(Glyco_hydro_2)
5 GLY A 719
GLY A 724
ASP A 723
ASP A 710
PRO A 601
None
1.22A 4rtsA-4cvuA:
undetectable
4rtsA-4cvuA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4de8 CPS2A

(Streptococcus
pneumoniae)
PF02916
(DNA_PPF)
PF03816
(LytR_cpsA_psr)
5 GLY A 291
ILE A 191
ASN A 190
TYR A 450
ASP A 275
None
1.05A 4rtsA-4de8A:
undetectable
4rtsA-4de8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Bacillus
subtilis)
PF00268
(Ribonuc_red_sm)
5 ILE A 190
SER A 104
TYR A 105
PRO A 175
TYR A 174
None
1.22A 4rtsA-4dr0A:
undetectable
4rtsA-4dr0A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe9 OUTER MEMBRANE
PROTEIN SUSF


(Bacteroides
thetaiotaomicron)
PF16411
(SusF_SusE)
PF17142
(DUF5115)
5 GLY A 480
PHE A 449
GLY A 451
ASP A 450
TYR A 455
None
1.19A 4rtsA-4fe9A:
undetectable
4rtsA-4fe9A:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gom DNA ADENINE
METHYLASE


(Escherichia
coli)
PF02086
(MethyltransfD12)
6 TRP D  10
GLY D  12
GLY D  37
ASP D  54
ASN D  56
TYR D 184
0Y0  D 301 (-4.5A)
None
0Y0  D 301 ( 3.8A)
0Y0  D 301 (-2.8A)
None
0Y0  D 301 (-3.4A)
0.93A 4rtsA-4gomD:
38.8
4rtsA-4gomD:
92.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gom DNA ADENINE
METHYLASE


(Escherichia
coli)
PF02086
(MethyltransfD12)
11 TRP D  10
PHE D  35
GLY D  37
ASP D  54
ILE D  55
ASN D  56
SER D 164
TYR D 165
ASP D 181
PRO D 183
TYR D 184
0Y0  D 301 (-4.5A)
0Y0  D 301 (-4.4A)
0Y0  D 301 ( 3.8A)
0Y0  D 301 (-2.8A)
0Y0  D 301 (-3.8A)
None
0Y0  D 301 (-3.6A)
None
0Y0  D 301 (-3.2A)
0Y0  D 301 (-4.0A)
0Y0  D 301 (-3.4A)
0.28A 4rtsA-4gomD:
38.8
4rtsA-4gomD:
92.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0n DNMT2

(Spodoptera
frugiperda)
PF00145
(DNA_methylase)
5 GLY A  11
ASP A  33
ILE A  34
ASN A  35
PRO A  77
SAH  A 401 (-3.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.7A)
SAH  A 401 (-4.2A)
0.69A 4rtsA-4h0nA:
5.2
4rtsA-4h0nA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE


(Leucoagaricus
meleagris)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 GLY A 515
GLY A 317
ILE A 296
ASN A 313
SER A 294
None
0.98A 4rtsA-4h7uA:
undetectable
4rtsA-4h7uA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ied CLASS D
BETA-LACTAMASE


(Fusobacterium
nucleatum)
PF00905
(Transpeptidase)
5 GLY A 209
PHE A  31
GLY A  29
ILE A  21
TYR A 246
None
1.25A 4rtsA-4iedA:
undetectable
4rtsA-4iedA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II


(Acidothermus
cellulolyticus)
no annotation 5 GLY A 190
GLY A 213
ILE A 210
SER A 224
ASP A 170
None
None
None
None
EDO  A 817 (-4.1A)
1.09A 4rtsA-4lgnA:
undetectable
4rtsA-4lgnA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL


(Saccharomyces
cerevisiae)
PF01209
(Ubie_methyltran)
5 GLY A 121
ASP A 148
ILE A 149
ASN A 150
ASP A 117
None
SAM  A 602 (-2.9A)
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
None
1.14A 4rtsA-4obwA:
11.3
4rtsA-4obwA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oki PHTHIOCEROL
SYNTHESIS POLYKETIDE
SYNTHASE TYPE I PPSC


(Mycobacterium
tuberculosis)
PF00107
(ADH_zinc_N)
5 GLY A 763
GLY A 787
ILE A 790
SER A 685
ASP A 765
None
1.26A 4rtsA-4okiA:
undetectable
4rtsA-4okiA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oki PHTHIOCEROL
SYNTHESIS POLYKETIDE
SYNTHASE TYPE I PPSC


(Mycobacterium
tuberculosis)
PF00107
(ADH_zinc_N)
5 GLY A 763
GLY A 787
ILE A 790
SER A 685
TYR A 723
None
1.12A 4rtsA-4okiA:
undetectable
4rtsA-4okiA:
30.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT BETA


(Kluyvera
cryocrescens)
PF01804
(Penicil_amidase)
5 TRP B  65
GLY B  66
GLY B  58
ILE B  35
ASP B 484
None
1.18A 4rtsA-4pelB:
undetectable
4rtsA-4pelB:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4poo PUTATIVE RNA
METHYLASE


(Bacillus
subtilis)
PF06962
(rRNA_methylase)
5 GLY A  30
ASP A  52
ILE A  53
SER A  79
TYR A 141
SAM  A 301 (-3.5A)
SAM  A 301 (-2.9A)
SAM  A 301 (-3.7A)
SAM  A 301 (-2.9A)
None
0.60A 4rtsA-4pooA:
10.0
4rtsA-4pooA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE


(Trypanosoma
cruzi)
PF00342
(PGI)
5 TRP A 190
GLY A 192
PHE A 297
ILE A 312
ASN A 316
None
1.20A 4rtsA-4qfhA:
undetectable
4rtsA-4qfhA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qri HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE


(Leptospira
interrogans)
PF00156
(Pribosyltran)
5 GLY A  47
PHE A  40
ILE A  39
ASN A  65
TYR A  33
None
1.17A 4rtsA-4qriA:
2.8
4rtsA-4qriA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmj GLUCOSE-6-PHOSPHATE
ISOMERASE


(Colias
eurytheme)
PF00342
(PGI)
6 TRP A 145
GLY A 147
PHE A 246
ILE A 261
ASN A 265
TYR A 148
None
1.28A 4rtsA-4wmjA:
undetectable
4rtsA-4wmjA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE


(Micromonospora
griseorubida)
PF05711
(TylF)
5 GLY A 117
GLY A 190
ASP A 189
ILE A  57
ASP A 113
SAH  A 301 (-3.0A)
SAH  A 301 ( 4.0A)
MG  A 304 (-2.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-2.7A)
1.18A 4rtsA-4x81A:
7.3
4rtsA-4x81A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru RNL

(Capnocytophaga
gingivalis)
PF16542
(PNKP_ligase)
5 GLY B  64
ASP B 260
ILE B 258
ASN B 259
SER B 254
MG  B 505 (-4.7A)
None
None
None
None
1.08A 4rtsA-4xruB:
undetectable
4rtsA-4xruB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT


(Escherichia
coli)
PF01555
(N6_N4_Mtase)
5 PHE A 441
GLY A 443
ASP A 123
PRO A 125
TYR A 126
None
0.92A 4rtsA-4zcfA:
2.3
4rtsA-4zcfA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
FAD-BINDING SUBUNIT


(Sulfurisphaera
tokodaii)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
5 GLY B 208
GLY B 190
ILE B  95
ASN B  94
PRO B 120
None
None
FAD  B 301 (-4.1A)
None
None
1.25A 4rtsA-4zohB:
undetectable
4rtsA-4zohB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyx PROTEIN CDHR2

(Mus musculus)
PF00028
(Cadherin)
5 GLY A 137
ASP A 130
ILE A 101
ASN A 100
SER A 202
CA  A1003 ( 4.7A)
CA  A1003 (-2.1A)
None
CA  A1001 (-4.8A)
None
1.08A 4rtsA-5cyxA:
undetectable
4rtsA-5cyxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens)
PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C)
5 GLY A 333
GLY A 370
ASP A 394
ILE A 392
ASP A 356
GLY  A 333 ( 0.0A)
GLY  A 370 (-0.0A)
ASP  A 394 ( 0.6A)
ILE  A 392 ( 0.7A)
ASP  A 356 ( 0.6A)
1.25A 4rtsA-5d7wA:
undetectable
4rtsA-5d7wA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e72 N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE


(Thermococcus
kodakarensis)
PF01170
(UPF0020)
PF02926
(THUMP)
6 PHE A 187
GLY A 189
ASP A 208
ILE A 209
PRO A 256
TYR A 257
SAM  A 400 (-4.7A)
SAM  A 400 (-3.3A)
SAM  A 400 (-2.8A)
SAM  A 400 (-3.9A)
SAM  A 400 (-4.2A)
None
0.65A 4rtsA-5e72A:
13.2
4rtsA-5e72A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd5 FERRIC UPTAKE
REGULATION PROTEIN


(Rhizobium
leguminosarum)
PF01475
(FUR)
5 PHE A  76
GLY A  79
ASP A  78
ASP A  75
TYR A  83
None
1.15A 4rtsA-5fd5A:
undetectable
4rtsA-5fd5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN


(Hantaan
orthohantavirus)
PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8)
5 GLY A-303
ILE A-106
ASN A-105
TYR A-266
TYR A-273
None
1.08A 4rtsA-5fsgA:
undetectable
4rtsA-5fsgA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
5 GLY B1142
GLY B1136
ILE B1223
SER B1225
PRO B1179
FMT  B4007 (-3.4A)
None
None
None
None
1.24A 4rtsA-5gztB:
undetectable
4rtsA-5gztB:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057


(Thermoplasma
acidophilum)
PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2)
5 GLY A  87
PHE A 154
TYR A 157
PRO A 165
TYR A 166
None
1.16A 4rtsA-5h8wA:
undetectable
4rtsA-5h8wA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrp MARBERG VIRUS
MONOCLONAL ANTIBODY
MR78 FAB HEAVY CHAIN


(Homo sapiens)
no annotation 5 TRP H  43
GLY H  42
ILE H  30
SER H  31
TYR H  60
None
1.18A 4rtsA-5jrpH:
undetectable
4rtsA-5jrpH:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi)
PF00883
(Peptidase_M17)
5 GLY A 307
PHE A 165
TYR A 176
ASP A 213
PRO A 215
None
1.19A 4rtsA-5ntfA:
undetectable
4rtsA-5ntfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii)
no annotation 5 GLY A 505
GLY A 307
ILE A 286
ASN A 303
SER A 284
None
1.05A 4rtsA-5oc1A:
2.5
4rtsA-5oc1A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-)
no annotation 5 GLY A 358
PHE A 349
GLY A 351
SER A 367
PRO A 361
None
1.22A 4rtsA-5oieA:
undetectable
4rtsA-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Paraburkholderia
xenovorans)
PF00982
(Glyco_transf_20)
5 GLY A 377
PHE A 167
TYR A 206
ASP A 199
PRO A 168
None
1.26A 4rtsA-5v0tA:
undetectable
4rtsA-5v0tA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC


(Medicago
truncatula)
PF00815
(Histidinol_dh)
5 GLY A 217
PHE A 427
GLY A 189
ILE A 160
ASN A 161
None
1.20A 4rtsA-5vldA:
3.7
4rtsA-5vldA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whz ANTI-HIV CODV-FAB
HEAVY CHAIN
ANTI-HIV CODV-FAB
LIGHT CHAIN


(Homo sapiens;
Homo sapiens)
no annotation
no annotation
5 GLY H  42
GLY L  90
ILE L  22
SER L  21
ASP L 111
None
1.08A 4rtsA-5whzH:
undetectable
4rtsA-5whzH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-)
no annotation 5 PHE A 397
GLY A 246
ILE A 214
ASN A 217
PRO A 191
None
1.15A 4rtsA-5wmlA:
5.3
4rtsA-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A


(Pyrococcus
abyssi)
no annotation 5 PHE A 191
GLY A 193
ILE A 214
ASN A 215
PRO A 262
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
MTA  A 401 (-3.7A)
None
G  C  37 ( 4.1A)
0.82A 4rtsA-5wt3A:
10.6
4rtsA-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE


(Homo sapiens)
no annotation 6 GLY A  27
ASP A  48
ILE A  49
ASN A  50
SER A  84
ASP A  23
SAM  A 800 (-3.5A)
SAM  A 800 (-2.8A)
SAM  A 800 (-4.0A)
None
SAM  A 800 (-3.4A)
SAM  A 800 ( 4.5A)
1.23A 4rtsA-5wy0A:
10.2
4rtsA-5wy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE


(Paenibacillus
sp. 598K)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110)
5 TRP A 488
GLY A 527
GLY A 490
ASP A 491
SER A 535
None
1.24A 4rtsA-5x7sA:
undetectable
4rtsA-5x7sA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22


(Homo sapiens)
no annotation 5 GLY A 448
ASP A 459
ILE A 452
SER A 439
PRO A 445
None
CA  A 802 (-3.3A)
None
None
None
1.14A 4rtsA-5y31A:
undetectable
4rtsA-5y31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Danio rerio)
no annotation 5 GLY A 290
PHE A 285
GLY A 287
SER A  33
TYR A 283
None
1.24A 4rtsA-6enxA:
undetectable
4rtsA-6enxA:
20.30