SIMILAR PATTERNS OF AMINO ACIDS FOR 4RTS_A_SAMA301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvu | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermococcuslitoralis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 69ILE A 358ASN A 357ASP A 139PRO A 66 | None | 1.22A | 4rtsA-1bvuA:0.3 | 4rtsA-1bvuA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cp9 | PENICILLIN G AMIDASE (Providenciarettgeri) |
PF01804(Penicil_amidase) | 5 | TRP B 65GLY B 66GLY B 58ILE B 35ASP B 484 | None | 1.21A | 4rtsA-1cp9B:0.0 | 4rtsA-1cp9B:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dus | MJ0882 (Methanocaldococcusjannaschii) |
PF05175(MTS) | 5 | GLY A 65ASP A 84ILE A 85ASN A 86PRO A 131 | None | 0.70A | 4rtsA-1dusA:13.2 | 4rtsA-1dusA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1euz | GLUTAMATEDEHYDROGENASE (Thermococcusprofundus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 70ILE A 359ASN A 358ASP A 140PRO A 67 | SO4 A 601 (-3.3A)NoneNoneNoneNone | 1.13A | 4rtsA-1euzA:1.0 | 4rtsA-1euzA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fiw | BETA-ACROSIN HEAVYCHAINBETA-ACROSIN LIGHTCHAIN (Ovis aries;Ovis aries) |
PF00089(Trypsin)no annotation | 5 | GLY L 7GLY L 10ASN A 202SER A 202PRO A 253 | None | 1.22A | 4rtsA-1fiwL:undetectable | 4rtsA-1fiwL:5.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fw8 | PHOSPHOGLYCERATEKINASE (Saccharomycescerevisiae) |
PF00162(PGK) | 5 | PHE A 114ASP A 90ILE A 88ASN A 89TYR A 392 | None | 0.95A | 4rtsA-1fw8A:undetectable | 4rtsA-1fw8A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g60 | ADENINE-SPECIFICMETHYLTRANSFERASEMBOIIA (Moraxella bovis) |
PF01555(N6_N4_Mtase) | 7 | PHE A 220GLY A 222ASP A 241ASN A 243ASP A 30PRO A 32TYR A 33 | SAM A 500 (-4.6A)SAM A 500 (-3.2A)SAM A 500 (-2.9A)NoneSAM A 500 (-3.7A)NoneNone | 0.91A | 4rtsA-1g60A:2.2 | 4rtsA-1g60A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtm | GLUTAMATEDEHYDROGENASE (Pyrococcusfuriosus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 69ILE A 359ASN A 358ASP A 139PRO A 66 | None | 1.15A | 4rtsA-1gtmA:undetectable | 4rtsA-1gtmA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsx | GLUCOSE-INHIBITEDDIVISION PROTEIN B (Escherichiacoli) |
PF02527(GidB) | 5 | GLY A 99GLY A 75ILE A 81SER A 84PRO A 119 | None | 1.18A | 4rtsA-1jsxA:9.5 | 4rtsA-1jsxA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k5s | PENICILLIN G ACYLASEBETA SUBUNIT (Escherichiacoli) |
PF01804(Penicil_amidase) | 5 | TRP B 65GLY B 66GLY B 58ILE B 35ASP B 484 | None | 1.15A | 4rtsA-1k5sB:undetectable | 4rtsA-1k5sB:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nw5 | MODIFICATIONMETHYLASE RSRI (Rhodobactersphaeroides) |
PF01555(N6_N4_Mtase) | 5 | PHE A 250GLY A 252ASP A 271ASP A 65PRO A 67 | SAM A 401 (-4.7A)SAM A 401 (-3.3A)SAM A 401 (-2.9A)SAM A 401 (-3.3A)SAM A 401 (-4.3A) | 0.64A | 4rtsA-1nw5A:2.3 | 4rtsA-1nw5A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pqw | POLYKETIDE SYNTHASE (Mycobacteriumtuberculosis) |
PF00107(ADH_zinc_N) | 5 | GLY A 107GLY A 131ILE A 134SER A 29TYR A 67 | None | 1.13A | 4rtsA-1pqwA:5.7 | 4rtsA-1pqwA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q50 | GLUCOSE-6-PHOSPHATEISOMERASE (Leishmaniamexicana) |
PF00342(PGI) | 5 | TRP A 188GLY A 190PHE A 295ILE A 310ASN A 314 | None | 1.20A | 4rtsA-1q50A:undetectable | 4rtsA-1q50A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qpg | 3-PHOSPHOGLYCERATEKINASE (Saccharomycescerevisiae) |
PF00162(PGK) | 5 | PHE A 185ASP A 161ILE A 159ASN A 160TYR A 48 | None | 1.04A | 4rtsA-1qpgA:undetectable | 4rtsA-1qpgA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qvb | BETA-GLYCOSIDASE (Thermosphaeraaggregans) |
PF00232(Glyco_hydro_1) | 5 | GLY A 388GLY A 441ASP A 428TYR A 430TYR A 321 | None | 1.22A | 4rtsA-1qvbA:undetectable | 4rtsA-1qvbA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ud3 | AMYLASE (Bacillus sp.KSM-K38) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | GLY A 88ILE A 95ASN A 93TYR A 98ASP A 224 | None | 1.07A | 4rtsA-1ud3A:undetectable | 4rtsA-1ud3A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uwi | BETA-GALACTOSIDASE (Sulfolobussolfataricus) |
PF00232(Glyco_hydro_1) | 5 | GLY A 389GLY A 442ASP A 429TYR A 431TYR A 322 | None | 1.25A | 4rtsA-1uwiA:undetectable | 4rtsA-1uwiA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfj | DNA ADENINEMETHYLASE (Escherichiavirus T4) |
PF02086(MethyltransfD12) | 5 | GLY A 9GLY A 34ASP A 50PRO A 173TYR A 174 | NoneSAH A 401 (-3.2A)SAH A 401 (-2.9A)SAH A 401 (-4.0A)None | 0.75A | 4rtsA-1yfjA:19.1 | 4rtsA-1yfjA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfj | DNA ADENINEMETHYLASE (Escherichiavirus T4) |
PF02086(MethyltransfD12) | 7 | GLY A 9PHE A 32GLY A 34ASP A 50ILE A 51ASP A 171PRO A 173 | NoneSAH A 401 (-4.2A)SAH A 401 (-3.2A)SAH A 401 (-2.9A)SAH A 401 (-3.6A)SAH A 401 (-3.8A)SAH A 401 (-4.0A) | 0.42A | 4rtsA-1yfjA:19.1 | 4rtsA-1yfjA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2as0 | HYPOTHETICAL PROTEINPH1915 (Pyrococcushorikoshii) |
PF01472(PUA)PF10672(Methyltrans_SAM) | 5 | PHE A 225ASP A 247SER A 275ASP A 296PRO A 298 | None | 0.45A | 4rtsA-2as0A:11.3 | 4rtsA-2as0A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bll | PROTEIN YFBG (Escherichiacoli) |
PF01370(Epimerase) | 5 | PHE A 326GLY A 325ASP A 499ASN A 500SER A 509 | None | 1.25A | 4rtsA-2bllA:2.4 | 4rtsA-2bllA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpm | PROTEIN(ADENINE-SPECIFICMETHYLTRANSFERASEDPNII 1) (Streptococcuspneumoniae) |
PF02086(MethyltransfD12) | 9 | TRP A 17GLY A 19PHE A 43GLY A 45ASP A 62ASN A 64ASP A 194PRO A 196TYR A 197 | SAM A 300 (-4.3A)SAM A 300 (-4.4A)SAM A 300 (-4.2A)SAM A 300 (-3.6A)SAM A 300 (-2.8A)NoneSAM A 300 (-3.7A)SAM A 300 ( 4.1A)None | 0.74A | 4rtsA-2dpmA:9.6 | 4rtsA-2dpmA:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpm | PROTEIN(ADENINE-SPECIFICMETHYLTRANSFERASEDPNII 1) (Streptococcuspneumoniae) |
PF02086(MethyltransfD12) | 7 | TRP A 17GLY A 20PHE A 43GLY A 45ASP A 62ASN A 64ASP A 194 | SAM A 300 (-4.3A)SAM A 300 (-3.3A)SAM A 300 (-4.2A)SAM A 300 (-3.6A)SAM A 300 (-2.8A)NoneSAM A 300 (-3.7A) | 1.02A | 4rtsA-2dpmA:9.6 | 4rtsA-2dpmA:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eij | CYTOCHROME C OXIDASESUBUNIT 1 (Bos taurus) |
PF00115(COX1) | 5 | ASP A 227ILE A 229TYR A 231ASP A 221PRO A 131 | None | 1.20A | 4rtsA-2eijA:undetectable | 4rtsA-2eijA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2esr | METHYLTRANSFERASE (Streptococcuspyogenes) |
PF03602(Cons_hypoth95) | 5 | PHE A 49GLY A 51ASN A 73ASP A 117PRO A 119 | None | 0.88A | 4rtsA-2esrA:10.9 | 4rtsA-2esrA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5c | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
PF02153(PDH) | 5 | GLY A 39ASP A 62ILE A 63ASN A 64PRO A 100 | NAD A3686 (-3.3A)NAD A3686 (-2.8A)NAD A3686 (-3.9A)NoneNAD A3686 (-4.5A) | 0.99A | 4rtsA-2g5cA:5.4 | 4rtsA-2g5cA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2igt | SAM DEPENDENTMETHYLTRANSFERASE (Agrobacteriumfabrum) |
PF10672(Methyltrans_SAM) | 5 | PHE A 140GLY A 141ASP A 161ASP A 211PRO A 213 | SAM A1001 (-4.4A)NoneSAM A1001 (-2.9A)SAM A1001 (-2.8A)SAM A1001 (-3.2A) | 1.14A | 4rtsA-2igtA:9.7 | 4rtsA-2igtA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2igt | SAM DEPENDENTMETHYLTRANSFERASE (Agrobacteriumfabrum) |
PF10672(Methyltrans_SAM) | 5 | PHE A 140GLY A 141ASP A 161ASP A 211TYR A 253 | SAM A1001 (-4.4A)NoneSAM A1001 (-2.9A)SAM A1001 (-2.8A)SAM A1001 (-4.7A) | 1.26A | 4rtsA-2igtA:9.7 | 4rtsA-2igtA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjq | UNCHARACTERIZED RNAMETHYLTRANSFERASEPYRAB10780 (Pyrococcusabyssi) |
PF05958(tRNA_U5-meth_tr) | 6 | GLY A 280ASP A 299ASN A 301SER A 325ASP A 340PRO A 342 | SAH A1406 (-3.4A)SAH A1406 (-2.8A)NoneSAH A1406 (-4.0A)SAH A1406 (-3.8A)SAH A1406 (-4.1A) | 0.82A | 4rtsA-2jjqA:10.7 | 4rtsA-2jjqA:27.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nxf | PUTATIVE DIMETALPHOSPHATASE (Danio rerio) |
PF00149(Metallophos) | 5 | GLY A 270GLY A 264ASP A 13ILE A 287ASP A 266 | NoneNone ZN A 401 (-3.1A)NoneNone | 1.26A | 4rtsA-2nxfA:undetectable | 4rtsA-2nxfA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q27 | OXALYL-COADECARBOXYLASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 547GLY A 476ASP A 447ILE A 471ASN A 473 | None MG A1001 ( 4.1A) MG A1001 ( 2.8A)NoneNone | 1.25A | 4rtsA-2q27A:2.7 | 4rtsA-2q27A:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vt2 | REDOX-SENSINGTRANSCRIPTIONALREPRESSOR REX (Bacillussubtilis) |
PF02629(CoA_binding)PF06971(Put_DNA-bind_N) | 5 | GLY A 94ASP A 118ILE A 119ASN A 120PRO A 154 | NAD A1210 (-3.3A)NAD A1210 (-2.8A)NAD A1210 (-4.0A)NoneNAD A1210 (-4.1A) | 0.94A | 4rtsA-2vt2A:undetectable | 4rtsA-2vt2A:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wk1 | NOVP (Actinoalloteichuscyanogriseus) |
PF05711(TylF) | 5 | GLY A 126GLY A 197ASP A 196ILE A 66ASP A 122 | SAH A 301 (-3.0A)EDO A 551 ( 3.7A)SAH A 301 ( 3.5A)SAH A 301 (-4.1A)SAH A 301 (-2.7A) | 1.15A | 4rtsA-2wk1A:undetectable | 4rtsA-2wk1A:25.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu8 | GLUCOSE-6-PHOSPHATEISOMERASE (Mycobacteriumtuberculosis) |
PF00342(PGI) | 5 | TRP A 141GLY A 143PHE A 242ILE A 257ASN A 261 | None | 1.19A | 4rtsA-2wu8A:undetectable | 4rtsA-2wu8A:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yz1 | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPESUBSTRATE 1 (Mus musculus) |
PF07686(V-set) | 5 | GLY A 101PHE A 98GLY A 38SER A 111ASP A 106 | None | 1.13A | 4rtsA-2yz1A:undetectable | 4rtsA-2yz1A:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ay0 | UNCHARACTERIZEDPROTEIN MJ0883 (Methanocaldococcusjannaschii) |
PF02475(Met_10) | 5 | PHE A 203GLY A 205ASP A 223ILE A 224ASN A 225 | ADN A 401 (-4.9A)ADN A 401 ( 4.0A)ADN A 401 (-2.6A)ADN A 401 (-3.7A)ADN A 401 (-4.9A) | 0.56A | 4rtsA-3ay0A:11.4 | 4rtsA-3ay0A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdx | SUCCINYLGLUTAMATEDESUCCINYLASE/ASPARTOACYLASE (Rhodobactersphaeroides) |
PF04952(AstE_AspA) | 5 | GLY A 151ASP A 112ILE A 113ASN A 114TYR A 66 | None | 1.24A | 4rtsA-3cdxA:undetectable | 4rtsA-3cdxA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cp7 | ALKALINE SERINEPROTEASE AL20 (Nesterenkoniaaethiopica) |
PF13365(Trypsin_2) | 5 | GLY A 64GLY A 138SER A 143TYR A 128PRO A 3 | None | 1.16A | 4rtsA-3cp7A:undetectable | 4rtsA-3cp7A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dli | METHYLTRANSFERASE (Archaeoglobusfulgidus) |
PF13489(Methyltransf_23) | 5 | PHE A 351GLY A 292ASP A 311ILE A 312ASN A 313 | None | 0.82A | 4rtsA-3dliA:10.4 | 4rtsA-3dliA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egi | TRIMETHYLGUANOSINESYNTHASE HOMOLOG (Homo sapiens) |
PF09445(Methyltransf_15) | 5 | PHE A 698GLY A 700ASP A 719ILE A 720PRO A 765 | ADP A 3 (-4.5A)ADP A 3 (-3.5A)ADP A 3 (-2.9A)ADP A 3 (-3.8A)ADP A 3 (-3.3A) | 0.44A | 4rtsA-3egiA:11.5 | 4rtsA-3egiA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2b | DNA-DIRECTED DNAPOLYMERASE III ALPHACHAIN (Geobacilluskaustophilus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | PHE A1085ASP A1086ILE A1005PRO A 387TYR A 390 | None | 1.27A | 4rtsA-3f2bA:undetectable | 4rtsA-3f2bA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdh | TRIMETHYLGUANOSINESYNTHASE HOMOLOG (Homo sapiens) |
PF09445(Methyltransf_15) | 5 | PHE A 698GLY A 700ASP A 719ILE A 720PRO A 765 | SAH A 854 (-4.3A)SAH A 854 (-3.3A)SAH A 854 (-2.9A)SAH A 854 (-3.6A)SAH A 854 (-3.8A) | 0.50A | 4rtsA-3gdhA:12.3 | 4rtsA-3gdhA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ggg | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
no annotation | 5 | GLY D 39ASP D 62ILE D 63ASN D 64PRO D 100 | NAD D6686 (-3.3A)NAD D6686 (-2.9A)NAD D6686 (-4.0A)NoneNAD D6686 (-4.6A) | 0.95A | 4rtsA-3gggD:undetectable | 4rtsA-3gggD:25.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grz | RIBOSOMAL PROTEINL11METHYLTRANSFERASE (Lactobacillusdelbrueckii) |
PF06325(PrmA) | 5 | GLY A 158GLY A 186ASP A 206ILE A 207SER A 233 | NoneNoneGOL A 322 (-3.5A)GOL A 322 (-4.1A)GOL A 322 ( 4.3A) | 0.63A | 4rtsA-3grzA:10.9 | 4rtsA-3grzA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjb | GLUCOSE-6-PHOSPHATEISOMERASE (Vibrio cholerae) |
PF00342(PGI) | 5 | TRP A 140GLY A 142PHE A 241ILE A 256ASN A 260 | None | 1.17A | 4rtsA-3hjbA:undetectable | 4rtsA-3hjbA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ifs | GLUCOSE-6-PHOSPHATEISOMERASE (Bacillusanthracis) |
PF00342(PGI) | 5 | GLY A 242PHE A 400GLY A 237PRO A 250TYR A 252 | None | 1.17A | 4rtsA-3ifsA:undetectable | 4rtsA-3ifsA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3izq | ELONGATION FACTOR 1ALPHA-LIKE PROTEIN (Saccharomycescerevisiae) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF08938(HBS1_N) | 5 | GLY 1 489GLY 1 530ILE 1 266ASN 1 261SER 1 267 | None | 1.05A | 4rtsA-3izq1:undetectable | 4rtsA-3izq1:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jbl | NLR FAMILY CARDDOMAIN-CONTAININGPROTEIN 4 (Mus musculus) |
no annotation | 5 | GLY K1004PHE K 972GLY K 946ILE K 924ASP K 971 | None | 1.25A | 4rtsA-3jblK:undetectable | 4rtsA-3jblK:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 5 | GLY A 202ASP A 261ILE A 262PRO A 307TYR A 308 | GTP A 383 (-2.6A)GTP A 383 (-3.0A)GTP A 383 (-4.2A)GTP A 383 (-3.7A)None | 0.59A | 4rtsA-3lduA:10.9 | 4rtsA-3lduA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbu | GLUCOSE-6-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00342(PGI) | 5 | TRP A 139GLY A 141PHE A 240ILE A 255TYR A 142 | None | 1.26A | 4rtsA-3nbuA:undetectable | 4rtsA-3nbuA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3v | PHOSPHOGLYCERATEKINASE (Campylobacterjejuni) |
PF00162(PGK) | 5 | PHE A 173ASP A 145ILE A 143ASN A 144TYR A 48 | None | 0.98A | 4rtsA-3q3vA:3.5 | 4rtsA-3q3vA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qv2 | 5-CYTOSINE DNAMETHYLTRANSFERASE (Entamoebahistolytica) |
PF00145(DNA_methylase) | 6 | PHE A 12GLY A 14ASP A 37ILE A 38ASN A 39PRO A 80 | SAH A 323 (-4.4A)SAH A 323 (-3.6A)SAH A 323 (-2.9A)SAH A 323 (-4.0A)SAH A 323 (-4.8A)SAH A 323 (-4.4A) | 0.87A | 4rtsA-3qv2A:6.1 | 4rtsA-3qv2A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgz | HYDROXYACID OXIDASE2 (Rattusnorvegicus) |
PF01070(FMN_dh) | 5 | PHE A 299GLY A 301ILE A 298TYR A 276TYR A 102 | NoneFMN A 401 (-3.4A)NoneNoneNone | 1.15A | 4rtsA-3sgzA:undetectable | 4rtsA-3sgzA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubg | NEURAL-CADHERIN (Drosophilamelanogaster) |
PF00028(Cadherin) | 5 | GLY A 625ASP A 622ILE A 578ASN A 577TYR A 542 | None CA A 901 (-3.5A)NoneNoneNone | 1.17A | 4rtsA-3ubgA:undetectable | 4rtsA-3ubgA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubh | NEURAL-CADHERIN (Drosophilamelanogaster) |
PF00028(Cadherin) | 5 | GLY A 625ASP A 622ILE A 578ASN A 577TYR A 542 | None CA A 854 (-3.3A)NoneNoneNone | 1.13A | 4rtsA-3ubhA:undetectable | 4rtsA-3ubhA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vta | CUCUMISIN (Cucumis melo) |
PF00082(Peptidase_S8) | 5 | GLY A 164GLY A 266ASP A 268ILE A 134PRO A 159 | None | 1.25A | 4rtsA-3vtaA:undetectable | 4rtsA-3vtaA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgh | REDOX-SENSINGTRANSCRIPTIONALREPRESSOR REX (Thermoanaerobacterethanolicus) |
PF02629(CoA_binding)PF06971(Put_DNA-bind_N) | 5 | GLY A 93ASP A 117ILE A 118ASN A 119PRO A 155 | NAI A 301 (-3.3A)NAI A 301 (-2.8A)NAI A 301 (-4.1A)NoneNAI A 301 (-4.3A) | 0.85A | 4rtsA-3wghA:undetectable | 4rtsA-3wghA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wq8 | BETA-GLUCOSIDASE (Pyrococcusfuriosus) |
PF00232(Glyco_hydro_1) | 5 | GLY A 374GLY A 427ASP A 414TYR A 416TYR A 307 | None | 1.21A | 4rtsA-3wq8A:undetectable | 4rtsA-3wq8A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvu | BETA-MANNOSIDASE (Trichodermaharzianum) |
PF00703(Glyco_hydro_2) | 5 | GLY A 719GLY A 724ASP A 723ASP A 710PRO A 601 | None | 1.22A | 4rtsA-4cvuA:undetectable | 4rtsA-4cvuA:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4de8 | CPS2A (Streptococcuspneumoniae) |
PF02916(DNA_PPF)PF03816(LytR_cpsA_psr) | 5 | GLY A 291ILE A 191ASN A 190TYR A 450ASP A 275 | None | 1.05A | 4rtsA-4de8A:undetectable | 4rtsA-4de8A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dr0 | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT BETA (Bacillussubtilis) |
PF00268(Ribonuc_red_sm) | 5 | ILE A 190SER A 104TYR A 105PRO A 175TYR A 174 | None | 1.22A | 4rtsA-4dr0A:undetectable | 4rtsA-4dr0A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fe9 | OUTER MEMBRANEPROTEIN SUSF (Bacteroidesthetaiotaomicron) |
PF16411(SusF_SusE)PF17142(DUF5115) | 5 | GLY A 480PHE A 449GLY A 451ASP A 450TYR A 455 | None | 1.19A | 4rtsA-4fe9A:undetectable | 4rtsA-4fe9A:19.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gom | DNA ADENINEMETHYLASE (Escherichiacoli) |
PF02086(MethyltransfD12) | 6 | TRP D 10GLY D 12GLY D 37ASP D 54ASN D 56TYR D 184 | 0Y0 D 301 (-4.5A)None0Y0 D 301 ( 3.8A)0Y0 D 301 (-2.8A)None0Y0 D 301 (-3.4A) | 0.93A | 4rtsA-4gomD:38.8 | 4rtsA-4gomD:92.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gom | DNA ADENINEMETHYLASE (Escherichiacoli) |
PF02086(MethyltransfD12) | 11 | TRP D 10PHE D 35GLY D 37ASP D 54ILE D 55ASN D 56SER D 164TYR D 165ASP D 181PRO D 183TYR D 184 | 0Y0 D 301 (-4.5A)0Y0 D 301 (-4.4A)0Y0 D 301 ( 3.8A)0Y0 D 301 (-2.8A)0Y0 D 301 (-3.8A)None0Y0 D 301 (-3.6A)None0Y0 D 301 (-3.2A)0Y0 D 301 (-4.0A)0Y0 D 301 (-3.4A) | 0.28A | 4rtsA-4gomD:38.8 | 4rtsA-4gomD:92.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h0n | DNMT2 (Spodopterafrugiperda) |
PF00145(DNA_methylase) | 5 | GLY A 11ASP A 33ILE A 34ASN A 35PRO A 77 | SAH A 401 (-3.3A)SAH A 401 (-3.1A)SAH A 401 (-4.0A)SAH A 401 (-4.7A)SAH A 401 (-4.2A) | 0.69A | 4rtsA-4h0nA:5.2 | 4rtsA-4h0nA:24.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7u | PYRANOSEDEHYDROGENASE (Leucoagaricusmeleagris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 515GLY A 317ILE A 296ASN A 313SER A 294 | None | 0.98A | 4rtsA-4h7uA:undetectable | 4rtsA-4h7uA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ied | CLASS DBETA-LACTAMASE (Fusobacteriumnucleatum) |
PF00905(Transpeptidase) | 5 | GLY A 209PHE A 31GLY A 29ILE A 21TYR A 246 | None | 1.25A | 4rtsA-4iedA:undetectable | 4rtsA-4iedA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgn | CELLULOSE-BINDING,FAMILY II (Acidothermuscellulolyticus) |
no annotation | 5 | GLY A 190GLY A 213ILE A 210SER A 224ASP A 170 | NoneNoneNoneNoneEDO A 817 (-4.1A) | 1.09A | 4rtsA-4lgnA:undetectable | 4rtsA-4lgnA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4obw | 2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOLMETHYLASE,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF01209(Ubie_methyltran) | 5 | GLY A 121ASP A 148ILE A 149ASN A 150ASP A 117 | NoneSAM A 602 (-2.9A)SAM A 602 (-3.8A)SAM A 602 (-4.9A)None | 1.14A | 4rtsA-4obwA:11.3 | 4rtsA-4obwA:21.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4oki | PHTHIOCEROLSYNTHESIS POLYKETIDESYNTHASE TYPE I PPSC (Mycobacteriumtuberculosis) |
PF00107(ADH_zinc_N) | 5 | GLY A 763GLY A 787ILE A 790SER A 685ASP A 765 | None | 1.26A | 4rtsA-4okiA:undetectable | 4rtsA-4okiA:30.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4oki | PHTHIOCEROLSYNTHESIS POLYKETIDESYNTHASE TYPE I PPSC (Mycobacteriumtuberculosis) |
PF00107(ADH_zinc_N) | 5 | GLY A 763GLY A 787ILE A 790SER A 685TYR A 723 | None | 1.12A | 4rtsA-4okiA:undetectable | 4rtsA-4okiA:30.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pel | PENICILLIN G ACYLASESUBUNIT BETA (Kluyveracryocrescens) |
PF01804(Penicil_amidase) | 5 | TRP B 65GLY B 66GLY B 58ILE B 35ASP B 484 | None | 1.18A | 4rtsA-4pelB:undetectable | 4rtsA-4pelB:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4poo | PUTATIVE RNAMETHYLASE (Bacillussubtilis) |
PF06962(rRNA_methylase) | 5 | GLY A 30ASP A 52ILE A 53SER A 79TYR A 141 | SAM A 301 (-3.5A)SAM A 301 (-2.9A)SAM A 301 (-3.7A)SAM A 301 (-2.9A)None | 0.60A | 4rtsA-4pooA:10.0 | 4rtsA-4pooA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfh | GLUCOSE-6-PHOSPHATEISOMERASE (Trypanosomacruzi) |
PF00342(PGI) | 5 | TRP A 190GLY A 192PHE A 297ILE A 312ASN A 316 | None | 1.20A | 4rtsA-4qfhA:undetectable | 4rtsA-4qfhA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qri | HYPOXANTHINE-GUANINE-XANTHINEPHOSPHORIBOSYLTRANSFERASE (Leptospirainterrogans) |
PF00156(Pribosyltran) | 5 | GLY A 47PHE A 40ILE A 39ASN A 65TYR A 33 | None | 1.17A | 4rtsA-4qriA:2.8 | 4rtsA-4qriA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wmj | GLUCOSE-6-PHOSPHATEISOMERASE (Coliaseurytheme) |
PF00342(PGI) | 6 | TRP A 145GLY A 147PHE A 246ILE A 261ASN A 265TYR A 148 | None | 1.28A | 4rtsA-4wmjA:undetectable | 4rtsA-4wmjA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x81 | MYCINAMICIN III3''-O-METHYLTRANSFERASE (Micromonosporagriseorubida) |
PF05711(TylF) | 5 | GLY A 117GLY A 190ASP A 189ILE A 57ASP A 113 | SAH A 301 (-3.0A)SAH A 301 ( 4.0A) MG A 304 (-2.5A)SAH A 301 (-4.3A)SAH A 301 (-2.7A) | 1.18A | 4rtsA-4x81A:7.3 | 4rtsA-4x81A:25.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xru | RNL (Capnocytophagagingivalis) |
PF16542(PNKP_ligase) | 5 | GLY B 64ASP B 260ILE B 258ASN B 259SER B 254 | MG B 505 (-4.7A)NoneNoneNoneNone | 1.08A | 4rtsA-4xruB:undetectable | 4rtsA-4xruB:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zcf | RESTRICTIONENDONUCLEASEECOP15I,MODIFICATION SUBUNIT (Escherichiacoli) |
PF01555(N6_N4_Mtase) | 5 | PHE A 441GLY A 443ASP A 123PRO A 125TYR A 126 | None | 0.92A | 4rtsA-4zcfA:2.3 | 4rtsA-4zcfA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zoh | PUTATIVEOXIDOREDUCTASEFAD-BINDING SUBUNIT (Sulfurisphaeratokodaii) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 5 | GLY B 208GLY B 190ILE B 95ASN B 94PRO B 120 | NoneNoneFAD B 301 (-4.1A)NoneNone | 1.25A | 4rtsA-4zohB:undetectable | 4rtsA-4zohB:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyx | PROTEIN CDHR2 (Mus musculus) |
PF00028(Cadherin) | 5 | GLY A 137ASP A 130ILE A 101ASN A 100SER A 202 | CA A1003 ( 4.7A) CA A1003 (-2.1A)None CA A1001 (-4.8A)None | 1.08A | 4rtsA-5cyxA:undetectable | 4rtsA-5cyxA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7w | SERRALYSIN (Serratiamarcescens) |
PF00353(HemolysinCabind)PF00413(Peptidase_M10)PF08548(Peptidase_M10_C) | 5 | GLY A 333GLY A 370ASP A 394ILE A 392ASP A 356 | GLY A 333 ( 0.0A)GLY A 370 (-0.0A)ASP A 394 ( 0.6A)ILE A 392 ( 0.7A)ASP A 356 ( 0.6A) | 1.25A | 4rtsA-5d7wA:undetectable | 4rtsA-5d7wA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e72 | N2,N2-DIMETHYLGUANOSINETRNAMETHYLTRANSFERASE (Thermococcuskodakarensis) |
PF01170(UPF0020)PF02926(THUMP) | 6 | PHE A 187GLY A 189ASP A 208ILE A 209PRO A 256TYR A 257 | SAM A 400 (-4.7A)SAM A 400 (-3.3A)SAM A 400 (-2.8A)SAM A 400 (-3.9A)SAM A 400 (-4.2A)None | 0.65A | 4rtsA-5e72A:13.2 | 4rtsA-5e72A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fd5 | FERRIC UPTAKEREGULATION PROTEIN (Rhizobiumleguminosarum) |
PF01475(FUR) | 5 | PHE A 76GLY A 79ASP A 78ASP A 75TYR A 83 | None | 1.15A | 4rtsA-5fd5A:undetectable | 4rtsA-5fd5A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsg | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HANTAVIRUSNUCLEOPROTEIN (Hantaanorthohantavirus) |
PF00846(Hanta_nucleocap)PF13416(SBP_bac_8) | 5 | GLY A-303ILE A-106ASN A-105TYR A-266TYR A-273 | None | 1.08A | 4rtsA-5fsgA:undetectable | 4rtsA-5fsgA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzt | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 5 | GLY B1142GLY B1136ILE B1223SER B1225PRO B1179 | FMT B4007 (-3.4A)NoneNoneNoneNone | 1.24A | 4rtsA-5gztB:undetectable | 4rtsA-5gztB:13.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8w | ATP-DEPENDENT DNAHELICASE TA0057 (Thermoplasmaacidophilum) |
PF06733(DEAD_2)PF06777(HBB)PF13307(Helicase_C_2) | 5 | GLY A 87PHE A 154TYR A 157PRO A 165TYR A 166 | None | 1.16A | 4rtsA-5h8wA:undetectable | 4rtsA-5h8wA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jrp | MARBERG VIRUSMONOCLONAL ANTIBODYMR78 FAB HEAVY CHAIN (Homo sapiens) |
no annotation | 5 | TRP H 43GLY H 42ILE H 30SER H 31TYR H 60 | None | 1.18A | 4rtsA-5jrpH:undetectable | 4rtsA-5jrpH:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ntf | AMINOPEPTIDASE (Trypanosomacruzi) |
PF00883(Peptidase_M17) | 5 | GLY A 307PHE A 165TYR A 176ASP A 213PRO A 215 | None | 1.19A | 4rtsA-5ntfA:undetectable | 4rtsA-5ntfA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oc1 | ARYL-ALCOHOL OXIDASE (Pleurotuseryngii) |
no annotation | 5 | GLY A 505GLY A 307ILE A 286ASN A 303SER A 284 | None | 1.05A | 4rtsA-5oc1A:2.5 | 4rtsA-5oc1A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oie | - (-) |
no annotation | 5 | GLY A 358PHE A 349GLY A 351SER A 367PRO A 361 | None | 1.22A | 4rtsA-5oieA:undetectable | 4rtsA-5oieA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v0t | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Paraburkholderiaxenovorans) |
PF00982(Glyco_transf_20) | 5 | GLY A 377PHE A 167TYR A 206ASP A 199PRO A 168 | None | 1.26A | 4rtsA-5v0tA:undetectable | 4rtsA-5v0tA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vld | HISTIDINOLDEHYDROGENASE,CHLOROPLASTIC (Medicagotruncatula) |
PF00815(Histidinol_dh) | 5 | GLY A 217PHE A 427GLY A 189ILE A 160ASN A 161 | None | 1.20A | 4rtsA-5vldA:3.7 | 4rtsA-5vldA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5whz | ANTI-HIV CODV-FABHEAVY CHAINANTI-HIV CODV-FABLIGHT CHAIN (Homo sapiens;Homo sapiens) |
no annotationno annotation | 5 | GLY H 42GLY L 90ILE L 22SER L 21ASP L 111 | None | 1.08A | 4rtsA-5whzH:undetectable | 4rtsA-5whzH:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wml | - (-) |
no annotation | 5 | PHE A 397GLY A 246ILE A 214ASN A 217PRO A 191 | None | 1.15A | 4rtsA-5wmlA:5.3 | 4rtsA-5wmlA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wt3 | TRNA(GUANINE(37)-N1)-METHYLTRANSFERASE TRM5A (Pyrococcusabyssi) |
no annotation | 5 | PHE A 191GLY A 193ILE A 214ASN A 215PRO A 262 | MTA A 401 (-4.4A)MTA A 401 (-3.6A)MTA A 401 (-3.7A)None G C 37 ( 4.1A) | 0.82A | 4rtsA-5wt3A:10.6 | 4rtsA-5wt3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wy0 | SMALL RNA2'-O-METHYLTRANSFERASE (Homo sapiens) |
no annotation | 6 | GLY A 27ASP A 48ILE A 49ASN A 50SER A 84ASP A 23 | SAM A 800 (-3.5A)SAM A 800 (-2.8A)SAM A 800 (-4.0A)NoneSAM A 800 (-3.4A)SAM A 800 ( 4.5A) | 1.23A | 4rtsA-5wy0A:10.2 | 4rtsA-5wy0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 5 | TRP A 488GLY A 527GLY A 490ASP A 491SER A 535 | None | 1.24A | 4rtsA-5x7sA:undetectable | 4rtsA-5x7sA:13.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y31 | DISINTEGRIN ANDMETALLOPROTEINASEDOMAIN-CONTAININGPROTEIN 22 (Homo sapiens) |
no annotation | 5 | GLY A 448ASP A 459ILE A 452SER A 439PRO A 445 | None CA A 802 (-3.3A)NoneNoneNone | 1.14A | 4rtsA-5y31A:undetectable | 4rtsA-5y31A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 5 | GLY A 290PHE A 285GLY A 287SER A 33TYR A 283 | None | 1.24A | 4rtsA-6enxA:undetectable | 4rtsA-6enxA:20.30 |