SIMILAR PATTERNS OF AMINO ACIDS FOR 4RTR_A_SAMA301_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvu | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermococcuslitoralis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 69ILE A 358ASN A 357ASP A 139PRO A 66 | None | 1.22A | 4rtrA-1bvuA:undetectable | 4rtrA-1bvuA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1esc | ESTERASE (Streptomycesscabiei) |
PF13472(Lipase_GDSL_2) | 5 | GLY A 250ASN A 285TYR A 41PRO A 187TYR A 246 | None | 1.47A | 4rtrA-1escA:undetectable | 4rtrA-1escA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1euz | GLUTAMATEDEHYDROGENASE (Thermococcusprofundus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 70ILE A 359ASN A 358ASP A 140PRO A 67 | SO4 A 601 (-3.3A)NoneNoneNoneNone | 1.12A | 4rtrA-1euzA:undetectable | 4rtrA-1euzA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fw8 | PHOSPHOGLYCERATEKINASE (Saccharomycescerevisiae) |
PF00162(PGK) | 5 | PHE A 114ASP A 90ILE A 88ASN A 89TYR A 392 | None | 0.99A | 4rtrA-1fw8A:undetectable | 4rtrA-1fw8A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g60 | ADENINE-SPECIFICMETHYLTRANSFERASEMBOIIA (Moraxella bovis) |
PF01555(N6_N4_Mtase) | 6 | PHE A 220ASP A 241ASN A 243ASP A 30PRO A 32TYR A 33 | SAM A 500 (-4.6A)SAM A 500 (-2.9A)NoneSAM A 500 (-3.7A)NoneNone | 0.86A | 4rtrA-1g60A:3.2 | 4rtrA-1g60A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtm | GLUTAMATEDEHYDROGENASE (Pyrococcusfuriosus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 69ILE A 359ASN A 358ASP A 139PRO A 66 | None | 1.16A | 4rtrA-1gtmA:undetectable | 4rtrA-1gtmA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzv | GLUCOSE-6-PHOSPHATEISOMERASE (Sus scrofa) |
PF00342(PGI) | 5 | TRP A 140GLY A 142PHE A 242ILE A 257TYR A 143 | None | 1.37A | 4rtrA-1gzvA:3.9 | 4rtrA-1gzvA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp. PCC 6803) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | GLY A1244ILE A1025ASN A1026SER A1285ASP A1249 | None | 1.49A | 4rtrA-1ofeA:undetectable | 4rtrA-1ofeA:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q50 | GLUCOSE-6-PHOSPHATEISOMERASE (Leishmaniamexicana) |
PF00342(PGI) | 5 | TRP A 188GLY A 190PHE A 295ILE A 310ASN A 314 | None | 1.26A | 4rtrA-1q50A:4.0 | 4rtrA-1q50A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qpg | 3-PHOSPHOGLYCERATEKINASE (Saccharomycescerevisiae) |
PF00162(PGK) | 5 | PHE A 185ASP A 161ILE A 159ASN A 160TYR A 48 | None | 1.08A | 4rtrA-1qpgA:4.6 | 4rtrA-1qpgA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s3i | 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE (Rattusnorvegicus) |
PF00551(Formyl_trans_N)PF02911(Formyl_trans_C) | 5 | GLY A 43PHE A 30ILE A 90TYR A 73TYR A 16 | None | 1.46A | 4rtrA-1s3iA:2.5 | 4rtrA-1s3iA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1si1 | IRON BINDING PROTEINFBPA (Mannheimiahaemolytica) |
PF13343(SBP_bac_6) | 5 | GLY A 118ILE A 194SER A 193TYR A 106PRO A 221 | None | 1.46A | 4rtrA-1si1A:undetectable | 4rtrA-1si1A:24.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5l | PRION PROTEIN (Trachemysscripta) |
PF00377(Prion) | 5 | PHE A 176ASP A 179ILE A 183ASN A 182TYR A 163 | None | 1.40A | 4rtrA-1u5lA:undetectable | 4rtrA-1u5lA:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wky | ENDO-BETA-1,4-MANNANASE (Bacillus sp.JAMB-602) |
PF00150(Cellulase) | 5 | TRP A 353GLY A 352ILE A 482SER A 481PRO A 362 | None | 1.31A | 4rtrA-1wkyA:undetectable | 4rtrA-1wkyA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfj | DNA ADENINEMETHYLASE (Escherichiavirus T4) |
PF02086(MethyltransfD12) | 5 | GLY A 9ASP A 50ASP A 171PRO A 173TYR A 174 | NoneSAH A 401 (-2.9A)SAH A 401 (-3.8A)SAH A 401 (-4.0A)None | 0.79A | 4rtrA-1yfjA:26.2 | 4rtrA-1yfjA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfj | DNA ADENINEMETHYLASE (Escherichiavirus T4) |
PF02086(MethyltransfD12) | 6 | GLY A 9PHE A 32ASP A 50ILE A 51ASP A 171PRO A 173 | NoneSAH A 401 (-4.2A)SAH A 401 (-2.9A)SAH A 401 (-3.6A)SAH A 401 (-3.8A)SAH A 401 (-4.0A) | 0.37A | 4rtrA-1yfjA:26.2 | 4rtrA-1yfjA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2as0 | HYPOTHETICAL PROTEINPH1915 (Pyrococcushorikoshii) |
PF01472(PUA)PF10672(Methyltrans_SAM) | 5 | PHE A 225ASP A 247SER A 275ASP A 296PRO A 298 | None | 0.49A | 4rtrA-2as0A:10.2 | 4rtrA-2as0A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2de0 | ALPHA-(1,6)-FUCOSYLTRANSFERASE (Homo sapiens) |
PF14604(SH3_9) | 5 | PHE X 467ASP X 495ILE X 496TYR X 476TYR X 382 | None | 1.47A | 4rtrA-2de0X:undetectable | 4rtrA-2de0X:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpm | PROTEIN(ADENINE-SPECIFICMETHYLTRANSFERASEDPNII 1) (Streptococcuspneumoniae) |
PF02086(MethyltransfD12) | 8 | TRP A 17GLY A 19PHE A 43ASP A 62ASN A 64ASP A 194PRO A 196TYR A 197 | SAM A 300 (-4.3A)SAM A 300 (-4.4A)SAM A 300 (-4.2A)SAM A 300 (-2.8A)NoneSAM A 300 (-3.7A)SAM A 300 ( 4.1A)None | 0.72A | 4rtrA-2dpmA:28.3 | 4rtrA-2dpmA:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpm | PROTEIN(ADENINE-SPECIFICMETHYLTRANSFERASEDPNII 1) (Streptococcuspneumoniae) |
PF02086(MethyltransfD12) | 7 | TRP A 17GLY A 20PHE A 43ASP A 62ASN A 64ASP A 194PRO A 196 | SAM A 300 (-4.3A)SAM A 300 (-3.3A)SAM A 300 (-4.2A)SAM A 300 (-2.8A)NoneSAM A 300 (-3.7A)SAM A 300 ( 4.1A) | 0.97A | 4rtrA-2dpmA:28.3 | 4rtrA-2dpmA:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eax | PEPTIDOGLYCANRECOGNITIONPROTEIN-I-BETA (Homo sapiens) |
PF01510(Amidase_2) | 5 | ASP A 265ILE A 264SER A 269TYR A 263ASP A 258 | None | 1.48A | 4rtrA-2eaxA:undetectable | 4rtrA-2eaxA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eij | CYTOCHROME C OXIDASESUBUNIT 1 (Bos taurus) |
PF00115(COX1) | 5 | ASP A 227ILE A 229TYR A 231ASP A 221PRO A 131 | None | 1.21A | 4rtrA-2eijA:undetectable | 4rtrA-2eijA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fna | CONSERVEDHYPOTHETICAL PROTEIN (Sulfolobussolfataricus) |
PF01637(ATPase_2) | 5 | TRP A 244GLY A 240PHE A 248ILE A 251TYR A 252 | None | 1.32A | 4rtrA-2fnaA:2.4 | 4rtrA-2fnaA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fyj | LOW-DENSITYLIPOPROTEINRECEPTOR-RELATEDPROTEIN 1 (Homo sapiens) |
PF00057(Ldl_recept_a) | 5 | GLY A 79PHE A 51ILE A 61ASN A 62ASP A 76 | None | 1.49A | 4rtrA-2fyjA:undetectable | 4rtrA-2fyjA:12.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iny | HEXON PROTEIN (Fowlaviadenovirus A) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | GLY A 661PHE A 668ASP A 557TYR A 670PRO A 658 | None | 1.46A | 4rtrA-2inyA:undetectable | 4rtrA-2inyA:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjq | UNCHARACTERIZED RNAMETHYLTRANSFERASEPYRAB10780 (Pyrococcusabyssi) |
PF05958(tRNA_U5-meth_tr) | 5 | ASP A 299ASN A 301SER A 325ASP A 340PRO A 342 | SAH A1406 (-2.8A)NoneSAH A1406 (-4.0A)SAH A1406 (-3.8A)SAH A1406 (-4.1A) | 0.75A | 4rtrA-2jjqA:8.9 | 4rtrA-2jjqA:27.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obe | HEXON (HumanmastadenovirusE) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | GLY A 672PHE A 679ASP A 568TYR A 681PRO A 669 | NoneNoneNoneMPD A1704 ( 4.7A)None | 1.33A | 4rtrA-2obeA:undetectable | 4rtrA-2obeA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obe | HEXON (HumanmastadenovirusE) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | GLY A 672PHE A 679TYR A 681ASP A 676PRO A 669 | NoneNoneMPD A1704 ( 4.7A)NoneNone | 1.32A | 4rtrA-2obeA:undetectable | 4rtrA-2obeA:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oxh | SOXZ PROTEIN (Paracoccusdenitrificans) |
no annotation | 5 | ILE Z 47ASN Z 49SER Z 32PRO Z 73TYR Z 74 | None | 1.42A | 4rtrA-2oxhZ:undetectable | 4rtrA-2oxhZ:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2paf | LACTOSE OPERONREPRESSOR (Escherichiacoli) |
PF13377(Peripla_BP_3) | 5 | GLY A 103ASP A 149ASN A 125SER A 158ASP A 129 | NoneNPF A 902 (-3.8A)NPF A 902 (-2.6A)NoneNone | 1.48A | 4rtrA-2pafA:4.3 | 4rtrA-2pafA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vcl | CYANOBACTERIALPHYCOERYTHROBILIN (Prochlorococcusphage P-SSM2) |
PF05996(Fe_bilin_red) | 5 | ILE A 182ASN A 184ASP A 98PRO A 100TYR A 127 | None | 1.47A | 4rtrA-2vclA:undetectable | 4rtrA-2vclA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z0f | PUTATIVEPHOSPHOGLUCOMUTASE (Thermusthermophilus) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | GLY A 299PHE A 279ASP A 280ILE A 213ASP A 277 | None | 1.48A | 4rtrA-2z0fA:undetectable | 4rtrA-2z0fA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cb5 | FACT COMPLEX SUBUNITSPT16 (Schizosaccharomycespombe) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 5 | GLY A 259PHE A 300SER A 204TYR A 437ASP A 277 | None | 1.28A | 4rtrA-3cb5A:undetectable | 4rtrA-3cb5A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdx | SUCCINYLGLUTAMATEDESUCCINYLASE/ASPARTOACYLASE (Rhodobactersphaeroides) |
PF04952(AstE_AspA) | 5 | GLY A 151ASP A 112ILE A 113ASN A 114TYR A 66 | None | 1.32A | 4rtrA-3cdxA:undetectable | 4rtrA-3cdxA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdx | SUCCINYLGLUTAMATEDESUCCINYLASE/ASPARTOACYLASE (Rhodobactersphaeroides) |
PF04952(AstE_AspA) | 5 | GLY A 151ASP A 112ILE A 113SER A 126TYR A 66 | None | 1.45A | 4rtrA-3cdxA:undetectable | 4rtrA-3cdxA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dli | METHYLTRANSFERASE (Archaeoglobusfulgidus) |
PF13489(Methyltransf_23) | 5 | ASP A 311ILE A 312ASN A 313SER A 329ASP A 288 | None | 1.48A | 4rtrA-3dliA:10.0 | 4rtrA-3dliA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3erb | COMPLEMENT C2 (Homo sapiens) |
PF00084(Sushi) | 5 | GLY A 85ASN A 160SER A 189PRO A 70TYR A 87 | None | 1.33A | 4rtrA-3erbA:undetectable | 4rtrA-3erbA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2b | DNA-DIRECTED DNAPOLYMERASE III ALPHACHAIN (Geobacilluskaustophilus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | PHE A1085ASP A1086ILE A1005PRO A 387TYR A 390 | None | 1.26A | 4rtrA-3f2bA:undetectable | 4rtrA-3f2bA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gnr | OS03G0212800 PROTEIN (Oryza sativa) |
PF00232(Glyco_hydro_1) | 5 | GLY A 396PHE A 442ILE A 174ASN A 177TYR A 127 | GLY A 396 ( 0.0A)PHE A 442 ( 1.3A)ILE A 174 ( 0.6A)ASN A 177 (-0.6A)TYR A 127 ( 1.3A) | 1.22A | 4rtrA-3gnrA:undetectable | 4rtrA-3gnrA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjb | GLUCOSE-6-PHOSPHATEISOMERASE (Vibrio cholerae) |
PF00342(PGI) | 5 | TRP A 140GLY A 142PHE A 241ILE A 256ASN A 260 | None | 1.24A | 4rtrA-3hjbA:undetectable | 4rtrA-3hjbA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jr3 | NAD-DEPENDENTDEACETYLASE (Thermotogamaritima) |
PF02146(SIR2) | 5 | GLY A 23PHE A 33ILE A 68ASP A 32PRO A 31 | None | 1.41A | 4rtrA-3jr3A:3.2 | 4rtrA-3jr3A:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ls2 | S-FORMYLGLUTATHIONEHYDROLASE (Pseudoalteromonashaloplanktis) |
PF00756(Esterase) | 5 | GLY A 53PHE A 262ASP A 225ASN A 226TYR A 256 | None | 1.47A | 4rtrA-3ls2A:undetectable | 4rtrA-3ls2A:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbu | GLUCOSE-6-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00342(PGI) | 5 | TRP A 139GLY A 141PHE A 240ILE A 255TYR A 142 | None | 1.30A | 4rtrA-3nbuA:2.9 | 4rtrA-3nbuA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nx3 | ACETYLORNITHINEAMINOTRANSFERASE (Campylobacterjejuni) |
PF00202(Aminotran_3) | 5 | GLY A 51ILE A 381SER A 385ASP A 40PRO A 372 | None | 1.21A | 4rtrA-3nx3A:3.7 | 4rtrA-3nx3A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pih | UVRABC SYSTEMPROTEIN A (Thermotogamaritima) |
PF00005(ABC_tran) | 5 | GLY A 714PHE A 691ILE A 687TYR A 756TYR A 702 | None | 1.37A | 4rtrA-3pihA:5.1 | 4rtrA-3pihA:14.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3v | PHOSPHOGLYCERATEKINASE (Campylobacterjejuni) |
PF00162(PGK) | 5 | PHE A 173ASP A 145ILE A 143ASN A 144TYR A 48 | None | 1.01A | 4rtrA-3q3vA:3.6 | 4rtrA-3q3vA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qv2 | 5-CYTOSINE DNAMETHYLTRANSFERASE (Entamoebahistolytica) |
PF00145(DNA_methylase) | 5 | PHE A 12ASP A 37ILE A 38ASN A 39PRO A 80 | SAH A 323 (-4.4A)SAH A 323 (-2.9A)SAH A 323 (-4.0A)SAH A 323 (-4.8A)SAH A 323 (-4.4A) | 0.79A | 4rtrA-3qv2A:5.6 | 4rtrA-3qv2A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wcy | INTERFERONALPHA/BETA RECEPTOR1 (Mus musculus) |
PF01108(Tissue_fac)PF09294(Interfer-bind) | 5 | TRP A 130GLY A 124ILE A 179TYR A 189PRO A 105 | None | 1.41A | 4rtrA-3wcyA:undetectable | 4rtrA-3wcyA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zif | HEXON PROTEIN (BovinemastadenovirusB) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | GLY A 652PHE A 659ASP A 550SER A 662TYR A 661 | None | 1.39A | 4rtrA-3zifA:undetectable | 4rtrA-3zifA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dr0 | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT BETA (Bacillussubtilis) |
PF00268(Ribonuc_red_sm) | 5 | ILE A 190SER A 104TYR A 105PRO A 175TYR A 174 | None | 1.22A | 4rtrA-4dr0A:undetectable | 4rtrA-4dr0A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ez5 | CYCLIN-DEPENDENTKINASE 6 (Homo sapiens) |
PF00069(Pkinase) | 5 | TRP A 203ILE A 289SER A 293ASP A 201PRO A 199 | None | 1.44A | 4rtrA-4ez5A:undetectable | 4rtrA-4ez5A:20.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gom | DNA ADENINEMETHYLASE (Escherichiacoli) |
PF02086(MethyltransfD12) | 5 | TRP D 10GLY D 12ASP D 54ASN D 56TYR D 184 | 0Y0 D 301 (-4.5A)None0Y0 D 301 (-2.8A)None0Y0 D 301 (-3.4A) | 0.96A | 4rtrA-4gomD:38.7 | 4rtrA-4gomD:92.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gom | DNA ADENINEMETHYLASE (Escherichiacoli) |
PF02086(MethyltransfD12) | 10 | TRP D 10PHE D 35ASP D 54ILE D 55ASN D 56SER D 164TYR D 165ASP D 181PRO D 183TYR D 184 | 0Y0 D 301 (-4.5A)0Y0 D 301 (-4.4A)0Y0 D 301 (-2.8A)0Y0 D 301 (-3.8A)None0Y0 D 301 (-3.6A)None0Y0 D 301 (-3.2A)0Y0 D 301 (-4.0A)0Y0 D 301 (-3.4A) | 0.28A | 4rtrA-4gomD:38.7 | 4rtrA-4gomD:92.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha4 | BETA-GALACTOSIDASE (Acidilobussaccharovorans) |
PF00232(Glyco_hydro_1) | 5 | GLY A 339PHE A 361SER A 478TYR A 398PRO A 353 | None | 1.39A | 4rtrA-4ha4A:undetectable | 4rtrA-4ha4A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hf7 | PUTATIVEACYLHYDROLASE (Bacteroidesthetaiotaomicron) |
PF13472(Lipase_GDSL_2) | 5 | PHE A 131ILE A 179ASN A 176TYR A 182TYR A 129 | None | 1.41A | 4rtrA-4hf7A:4.0 | 4rtrA-4hf7A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iyj | GDSL-LIKE PROTEIN (Bacteroidesuniformis) |
PF13472(Lipase_GDSL_2) | 5 | PHE A 123ILE A 171ASN A 168TYR A 174TYR A 121 | None | 1.41A | 4rtrA-4iyjA:4.2 | 4rtrA-4iyjA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jn7 | ENOLASE (Agrobacteriumtumefaciens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 390ASP A 156ILE A 157PRO A 385TYR A 392 | NoneNoneEDO A 404 ( 4.1A)NoneNone | 1.45A | 4rtrA-4jn7A:undetectable | 4rtrA-4jn7A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jy6 | PGT123 HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | TRP B 36GLY B 49ILE B 29SER B 28TYR B 50 | None | 1.50A | 4rtrA-4jy6B:undetectable | 4rtrA-4jy6B:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nk5 | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE[NADH] (CandidatusLiberibacterasiaticus) |
PF13561(adh_short_C2) | 5 | GLY A 138PHE A 88ILE A 142ASN A 185ASP A 87 | None | 1.37A | 4rtrA-4nk5A:3.3 | 4rtrA-4nk5A:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oju | HYPOTHETICAL LEUCINERICH REPEAT PROTEIN (Pseudoflavonifractorcapillosus) |
PF13306(LRR_5) | 5 | GLY A 44PHE A 38ILE A 80TYR A 36TYR A 75 | None | 1.43A | 4rtrA-4ojuA:undetectable | 4rtrA-4ojuA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qri | HYPOXANTHINE-GUANINE-XANTHINEPHOSPHORIBOSYLTRANSFERASE (Leptospirainterrogans) |
PF00156(Pribosyltran) | 5 | GLY A 47PHE A 40ILE A 39ASN A 65TYR A 33 | None | 1.18A | 4rtrA-4qriA:3.9 | 4rtrA-4qriA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v2i | ESTERASE/LIPASE (Thalassospirasp. GB04J01) |
PF07859(Abhydrolase_3) | 5 | GLY A 85PHE A 287ILE A 303TYR A 280ASP A 286 | None | 1.46A | 4rtrA-4v2iA:undetectable | 4rtrA-4v2iA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wmj | GLUCOSE-6-PHOSPHATEISOMERASE (Coliaseurytheme) |
PF00342(PGI) | 5 | TRP A 145GLY A 147PHE A 246ILE A 261TYR A 148 | None | 1.35A | 4rtrA-4wmjA:undetectable | 4rtrA-4wmjA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wmj | GLUCOSE-6-PHOSPHATEISOMERASE (Coliaseurytheme) |
PF00342(PGI) | 5 | TRP A 145PHE A 246ILE A 261ASN A 265TYR A 148 | None | 1.36A | 4rtrA-4wmjA:undetectable | 4rtrA-4wmjA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xru | RNL (Capnocytophagagingivalis) |
PF16542(PNKP_ligase) | 5 | GLY B 64ASP B 260ILE B 258ASN B 259SER B 254 | MG B 505 (-4.7A)NoneNoneNoneNone | 1.05A | 4rtrA-4xruB:undetectable | 4rtrA-4xruB:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a22 | VESICULAR STOMATITISVIRUS L POLYMERASE (Vesicularstomatitisvirus) |
PF00946(Mononeg_RNA_pol)PF14314(Methyltrans_Mon)PF14318(Mononeg_mRNAcap) | 5 | TRP A 506GLY A1332SER A1171ASP A 457PRO A 456 | None | 1.39A | 4rtrA-5a22A:7.9 | 4rtrA-5a22A:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b8i | SERINE/THREONINE-PROTEIN PHOSPHATASE (Coccidioidesimmitis) |
PF00149(Metallophos) | 5 | GLY A 263PHE A 257ASP A 256TYR A 309TYR A 265 | None | 1.50A | 4rtrA-5b8iA:undetectable | 4rtrA-5b8iA:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5btr | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 5 | GLY A 355ASP A 348ILE A 347ASN A 346TYR A 317 | None | 1.31A | 4rtrA-5btrA:undetectable | 4rtrA-5btrA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d0f | UNCHARACTERIZEDPROTEIN ([Candida]glabrata) |
PF06202(GDE_C)PF14699(hGDE_N)PF14701(hDGE_amylase)PF14702(hGDE_central) | 5 | PHE A1444ASN A1449TYR A1443PRO A1373TYR A1375 | None | 1.49A | 4rtrA-5d0fA:undetectable | 4rtrA-5d0fA:11.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e72 | N2,N2-DIMETHYLGUANOSINETRNAMETHYLTRANSFERASE (Thermococcuskodakarensis) |
PF01170(UPF0020)PF02926(THUMP) | 5 | PHE A 187ASP A 208ILE A 209ASP A 254PRO A 256 | SAM A 400 (-4.7A)SAM A 400 (-2.8A)SAM A 400 (-3.9A)NoneSAM A 400 (-4.2A) | 0.83A | 4rtrA-5e72A:11.2 | 4rtrA-5e72A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e72 | N2,N2-DIMETHYLGUANOSINETRNAMETHYLTRANSFERASE (Thermococcuskodakarensis) |
PF01170(UPF0020)PF02926(THUMP) | 5 | PHE A 187ASP A 208ILE A 209PRO A 256TYR A 257 | SAM A 400 (-4.7A)SAM A 400 (-2.8A)SAM A 400 (-3.9A)SAM A 400 (-4.2A)None | 0.66A | 4rtrA-5e72A:11.2 | 4rtrA-5e72A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsg | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HANTAVIRUSNUCLEOPROTEIN (Hantaanorthohantavirus) |
PF00846(Hanta_nucleocap)PF13416(SBP_bac_8) | 5 | GLY A-303ILE A-106ASN A-105TYR A-266TYR A-273 | None | 1.09A | 4rtrA-5fsgA:undetectable | 4rtrA-5fsgA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8w | ATP-DEPENDENT DNAHELICASE TA0057 (Thermoplasmaacidophilum) |
PF06733(DEAD_2)PF06777(HBB)PF13307(Helicase_C_2) | 5 | GLY A 87PHE A 154TYR A 157PRO A 165TYR A 166 | None | 1.16A | 4rtrA-5h8wA:4.6 | 4rtrA-5h8wA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5isx | GRAMICIDIN SSYNTHASE 1 (Brevibacillusbrevis) |
PF00550(PP-binding)PF00668(Condensation) | 5 | GLY A 618ASP A 792ILE A 795SER A 794ASP A 673 | None | 1.25A | 4rtrA-5isxA:undetectable | 4rtrA-5isxA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jrp | MARBERG VIRUSMONOCLONAL ANTIBODYMR78 FAB HEAVY CHAIN (Homo sapiens) |
no annotation | 5 | TRP H 43GLY H 56ILE H 30SER H 31TYR H 60 | None | 1.38A | 4rtrA-5jrpH:undetectable | 4rtrA-5jrpH:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ntf | AMINOPEPTIDASE (Trypanosomacruzi) |
PF00883(Peptidase_M17) | 5 | GLY A 307PHE A 165TYR A 176ASP A 213PRO A 215 | None | 1.30A | 4rtrA-5ntfA:2.4 | 4rtrA-5ntfA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5od2 | BIFUNCTIONALADP-SPECIFICGLUCOKINASE/PHOSPHOFRUCTOKINASE (Methanocaldococcusjannaschii) |
no annotation | 5 | PHE A 139ILE A 124ASN A 144SER A 113TYR A 164 | None | 1.39A | 4rtrA-5od2A:3.7 | 4rtrA-5od2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tvg | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Burkholderiavietnamiensis) |
PF00982(Glyco_transf_20) | 5 | GLY A 365PHE A 159TYR A 198ASP A 191PRO A 160 | GOL A 504 (-3.7A)NoneNoneNoneNone | 1.31A | 4rtrA-5tvgA:2.1 | 4rtrA-5tvgA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uin | FORMYLTRANSFERASE (Salmonellaenterica) |
PF00551(Formyl_trans_N)PF13637(Ank_4) | 5 | GLY A 304ASP A 10ILE A 156ASN A 9SER A 157 | None | 1.05A | 4rtrA-5uinA:3.1 | 4rtrA-5uinA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v0t | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Paraburkholderiaxenovorans) |
PF00982(Glyco_transf_20) | 5 | GLY A 377PHE A 167TYR A 206ASP A 199PRO A 168 | None | 1.24A | 4rtrA-5v0tA:2.0 | 4rtrA-5v0tA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wy0 | SMALL RNA2'-O-METHYLTRANSFERASE (Homo sapiens) |
no annotation | 5 | ASP A 48ILE A 49ASN A 50SER A 84ASP A 23 | SAM A 800 (-2.8A)SAM A 800 (-4.0A)NoneSAM A 800 (-3.4A)SAM A 800 ( 4.5A) | 1.03A | 4rtrA-5wy0A:10.6 | 4rtrA-5wy0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y83 | MEMBRANE PROTEININSERTASE YIDC (Thermotogamaritima) |
no annotation | 5 | GLY A 180PHE A 72ASP A 73ILE A 50PRO A 141 | None | 1.50A | 4rtrA-5y83A:undetectable | 4rtrA-5y83A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6be3 | FAB (F598) HEAVYCHAIN (Homo sapiens) |
no annotation | 5 | TRP H 36GLY H 49ILE H 29SER H 28ASP H 98 | None | 1.33A | 4rtrA-6be3H:undetectable | 4rtrA-6be3H:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dbr | - (-) |
no annotation | 5 | TRP A 915GLY A 976ASP A 819ILE A 820ASN A 822 | None | 1.32A | 4rtrA-6dbrA:undetectable | 4rtrA-6dbrA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f42 | DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC1DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC2 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
no annotationno annotation | 5 | GLY B 764ILE A 564SER A 565TYR A 562ASP A 556 | None | 1.45A | 4rtrA-6f42B:undetectable | 4rtrA-6f42B:undetectable |