SIMILAR PATTERNS OF AMINO ACIDS FOR 4RTM_A_SAMA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gom DNA ADENINE
METHYLASE

(Escherichia
coli) 		PF02086
(MethyltransfD12) 		4 TRP D  10
SER D  40
ASP D  54
ASP D 181
 0Y0  D 301 (-4.5A)
None
0Y0  D 301 (-2.8A)
0Y0  D 301 (-3.2A)
 0.59A 4rtmA-4gomD:
38.9		 4rtmA-4gomD:
92.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfl AMIDOHYDROLASE EGTC

(Mycolicibacterium
smegmatis) 		PF13522
(GATase_6) 		4 TRP A  59
SER A 101
ASP A  68
ASP A  62
 None
 1.33A 4rtmA-4zflA:
0.0		 4rtmA-4zflA:
21.59