SIMILAR PATTERNS OF AMINO ACIDS FOR 4RTM_A_SAMA301_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fcd | FLAVOCYTOCHROME CSULFIDEDEHYDROGENASE(FLAVIN-BINDINGSUBUNIT) (Allochromatiumvinosum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind) | 5 | GLY A 10ALA A 18ILE A 289SER A 283PRO A 104 | NoneNoneNoneNoneFAD A 699 (-4.5A) | 0.75A | 4rtmA-1fcdA:undetectable | 4rtmA-1fcdA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g60 | ADENINE-SPECIFICMETHYLTRANSFERASEMBOIIA (Moraxella bovis) |
PF01555(N6_N4_Mtase) | 5 | PHE A 220GLY A 222ASN A 243PRO A 32TYR A 33 | SAM A 500 (-4.6A)SAM A 500 (-3.2A)NoneNoneNone | 0.65A | 4rtmA-1g60A:2.0 | 4rtmA-1g60A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h81 | POLYAMINE OXIDASE (Zea mays) |
PF01593(Amino_oxidase) | 5 | GLY A 42GLY A 41GLY A 11ALA A 12ILE A 276 | FAD A 579 (-3.2A)NoneFAD A 579 (-3.1A)NoneNone | 1.03A | 4rtmA-1h81A:2.0 | 4rtmA-1h81A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1led | WEST-CENTRAL AFRICANLEGUME LECTIN IV (Griffoniasimplicifolia) |
PF00139(Lectin_legB) | 5 | GLY A 107GLY A 106GLY A 90ILE A 146TYR A 143 | GAL A 253 ( 3.4A)FUC A 254 ( 3.8A)NoneNoneNone | 0.96A | 4rtmA-1ledA:undetectable | 4rtmA-1ledA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrw | METHANOLDEHYDROGENASESUBUNIT 1 (Paracoccusdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 5 | GLY A 182GLY A 240GLY A 175ALA A 176ILE A 152 | NoneNonePQQ A 701 (-3.7A)PQQ A 701 (-2.8A)None | 0.90A | 4rtmA-1lrwA:undetectable | 4rtmA-1lrwA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n47 | ISOLECTIN B4 (Vicia villosa) |
PF00139(Lectin_legB) | 5 | GLY A 103GLY A 102GLY A 86ILE A 138TYR A 135 | TNR A1401 (-3.4A)TNR A1401 ( 3.9A)NoneNoneNone | 1.05A | 4rtmA-1n47A:undetectable | 4rtmA-1n47A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qmo | MANNOSE BINDINGLECTIN, FRILMANNOSE BINDINGLECTIN, FRIL (Lablabpurpureus;Lablabpurpureus) |
PF00139(Lectin_legB)PF00139(Lectin_legB) | 5 | GLY A 104GLY A 103GLY A 87ILE E 155TYR E 152 | MAN A 302 (-3.7A)MAN A 302 ( 3.8A)NoneNoneNone | 1.04A | 4rtmA-1qmoA:undetectable | 4rtmA-1qmoA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qmo | MANNOSE BINDINGLECTIN, FRILMANNOSE BINDINGLECTIN, FRIL (Lablabpurpureus;Lablabpurpureus) |
PF00139(Lectin_legB)PF00139(Lectin_legB) | 5 | GLY A 104GLY A 103GLY A 87TYR E 152TYR E 147 | MAN A 302 (-3.7A)MAN A 302 ( 3.8A)NoneNoneNone | 0.91A | 4rtmA-1qmoA:undetectable | 4rtmA-1qmoA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1toa | PROTEIN (PERIPLASMICBINDING PROTEINTROA) (Treponemapallidum) |
PF01297(ZnuA) | 5 | GLY A 59GLY A 41ALA A 44PRO A 67TYR A 70 | None | 1.03A | 4rtmA-1toaA:undetectable | 4rtmA-1toaA:25.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ur4 | GALACTANASE (Bacilluslicheniformis) |
PF07745(Glyco_hydro_53) | 5 | GLY A 366GLY A 365GLY A 82ALA A 348ILE A 34 | None | 1.01A | 4rtmA-1ur4A:undetectable | 4rtmA-1ur4A:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ux6 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 5 | GLY A1127GLY A1128GLY A 848ILE A 844PRO A 860 | NoneNoneNoneNone CA A2009 ( 4.8A) | 0.88A | 4rtmA-1ux6A:undetectable | 4rtmA-1ux6A:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vqv | THIAMINEMONOPHOSPHATE KINASE (Aquifexaeolicus) |
PF00586(AIRS) | 5 | GLY A 77GLY A 76ALA A 74ILE A 65ASN A 68 | None | 0.95A | 4rtmA-1vqvA:undetectable | 4rtmA-1vqvA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x1n | 4-ALPHA-GLUCANOTRANSFERASE (Solanumtuberosum) |
PF02446(Glyco_hydro_77) | 5 | GLY A 325GLY A 328GLY A 349ILE A 356TYR A 245 | NoneNoneNoneNoneGOL A1002 (-4.7A) | 0.94A | 4rtmA-1x1nA:undetectable | 4rtmA-1x1nA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3l | HYPOTHETICAL PROTEINPH0495 (Pyrococcushorikoshii) |
PF05161(MOFRL)PF13660(DUF4147) | 5 | GLY A 342GLY A 341GLY A 378ALA A 376ILE A 428 | None | 1.04A | 4rtmA-1x3lA:3.3 | 4rtmA-1x3lA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xnf | LIPOPROTEIN NLPI (Escherichiacoli) |
PF07719(TPR_2)PF13181(TPR_8) | 5 | GLY A 143GLY A 144ALA A 149ASN A 135SER A 121 | None | 0.91A | 4rtmA-1xnfA:undetectable | 4rtmA-1xnfA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfj | DNA ADENINEMETHYLASE (Escherichiavirus T4) |
PF02086(MethyltransfD12) | 5 | GLY A 9GLY A 34ILE A 51PRO A 173TYR A 174 | NoneSAH A 401 (-3.2A)SAH A 401 (-3.6A)SAH A 401 (-4.0A)None | 1.05A | 4rtmA-1yfjA:26.3 | 4rtmA-1yfjA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfj | DNA ADENINEMETHYLASE (Escherichiavirus T4) |
PF02086(MethyltransfD12) | 5 | GLY A 9PHE A 32GLY A 34ILE A 51PRO A 173 | NoneSAH A 401 (-4.2A)SAH A 401 (-3.2A)SAH A 401 (-3.6A)SAH A 401 (-4.0A) | 0.47A | 4rtmA-1yfjA:26.3 | 4rtmA-1yfjA:27.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ahw | PUTATIVE ENZYME YDIF (Escherichiacoli) |
PF01144(CoA_trans) | 5 | GLY A 39GLY A 38GLY A 35ALA A 36ILE A 186 | None | 0.97A | 4rtmA-2ahwA:undetectable | 4rtmA-2ahwA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cdp | BETA-AGARASE 1 (Saccharophagusdegradans) |
PF03422(CBM_6) | 5 | GLY A 72GLY A 121ALA A 122SER A 28TYR A 40 | NoneNoneNoneNoneAAL A1006 ( 3.8A) | 1.00A | 4rtmA-2cdpA:undetectable | 4rtmA-2cdpA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cvt | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASELARGE CHAIN 1 (Saccharomycescerevisiae) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | GLY A 246GLY A 247GLY A 295ALA A 296TYR A 285 | None | 0.98A | 4rtmA-2cvtA:undetectable | 4rtmA-2cvtA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddt | SPHINGOMYELINPHOSPHODIESTERASE (Bacillus cereus) |
PF03372(Exo_endo_phos) | 5 | GLY A 101GLY A 102PHE A 133ALA A 104ILE A 115 | None | 0.93A | 4rtmA-2ddtA:undetectable | 4rtmA-2ddtA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dpm | PROTEIN(ADENINE-SPECIFICMETHYLTRANSFERASEDPNII 1) (Streptococcuspneumoniae) |
PF02086(MethyltransfD12) | 7 | GLY A 19GLY A 20PHE A 43GLY A 45ASN A 64PRO A 196TYR A 197 | SAM A 300 (-4.4A)SAM A 300 (-3.3A)SAM A 300 (-4.2A)SAM A 300 (-3.6A)NoneSAM A 300 ( 4.1A)None | 0.84A | 4rtmA-2dpmA:28.6 | 4rtmA-2dpmA:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ghb | MALTOSE ABCTRANSPORTER,PERIPLASMICMALTOSE-BINDINGPROTEIN (Thermotogamaritima) |
PF13416(SBP_bac_8) | 5 | GLY A 169GLY A 168GLY A 194SER A 153TYR A 159 | None | 1.04A | 4rtmA-2ghbA:undetectable | 4rtmA-2ghbA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oas | 4-HYDROXYBUTYRATECOENZYME ATRANSFERASE (Shewanellaoneidensis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 5 | GLY A 130GLY A 28ALA A 29ILE A 180SER A 182 | None | 1.03A | 4rtmA-2oasA:2.4 | 4rtmA-2oasA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2okb | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDOHYDROLASE (Vaccinia virus) |
PF00692(dUTPase) | 5 | GLY A 82GLY A 81GLY A 93ILE A 54TYR A 35 | None | 0.94A | 4rtmA-2okbA:undetectable | 4rtmA-2okbA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q9t | DING (Pseudomonasfluorescens) |
PF12849(PBP_like_2) | 5 | GLY A 179GLY A 178PHE A 117ILE A 136ASN A 122 | None | 0.97A | 4rtmA-2q9tA:undetectable | 4rtmA-2q9tA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qi9 | VITAMIN B12 IMPORTSYSTEM PERMEASEPROTEIN BTUC (Escherichiacoli) |
PF01032(FecCD) | 5 | GLY A 251GLY A 98ALA A 97ILE A 164SER A 167 | None | 0.80A | 4rtmA-2qi9A:undetectable | 4rtmA-2qi9A:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vpj | KELCH-LIKE PROTEIN12 (Homo sapiens) |
PF01344(Kelch_1) | 5 | GLY A 433GLY A 432GLY A 465ALA A 466TYR A 337 | NoneNoneNoneNoneACT A1569 ( 4.9A) | 0.99A | 4rtmA-2vpjA:undetectable | 4rtmA-2vpjA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtb | FATTY ACIDMULTIFUNCTIONALPROTEIN (ATMFP2) (Arabidopsisthaliana) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | GLY A 116GLY A 115GLY A 147ILE A 91TYR A 88 | None | 1.01A | 4rtmA-2wtbA:6.4 | 4rtmA-2wtbA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ygl | BLOOD GROUP A-ANDB-CLEAVINGENDO-BETA-GALACTOSIDASE (Streptococcuspneumoniae) |
PF08305(NPCBM) | 5 | GLY A 248GLY A 247PHE A 324ALA A 411TYR A 250 | None | 1.04A | 4rtmA-2yglA:undetectable | 4rtmA-2yglA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yky | BETA-TRANSAMINASE (Mesorhizobiumsp. LUK) |
PF00202(Aminotran_3) | 5 | GLY A 171GLY A 170GLY A 224ALA A 225GLN A 266 | NoneNoneNoneSFE A1546 (-3.4A)None | 1.05A | 4rtmA-2ykyA:undetectable | 4rtmA-2ykyA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9r | THIAMINEMONOPHOSPHATE KINASE (Aquifexaeolicus) |
PF00586(AIRS) | 5 | GLY A 77GLY A 76ALA A 74ILE A 65ASN A 68 | None | 0.96A | 4rtmA-3c9rA:undetectable | 4rtmA-3c9rA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d46 | PUTATIVE GALACTONATEDEHYDRATASE (Salmonellaenterica) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 187GLY A 188PHE A 170ALA A 180ASN A 376 | None | 1.04A | 4rtmA-3d46A:undetectable | 4rtmA-3d46A:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dy5 | ALLENE OXIDESYNTHASE-LIPOXYGENASE PROTEIN (Plexaurahomomalla) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | GLY A 421GLY A 383PHE A 418GLY A 389ALA A 388 | None | 1.00A | 4rtmA-3dy5A:undetectable | 4rtmA-3dy5A:13.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ekg | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Azotobactervinelandii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 177GLY A 178PHE A 160ALA A 170ASN A 367 | None | 0.91A | 4rtmA-3ekgA:undetectable | 4rtmA-3ekgA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ggg | PREPHENATEDEHYDROGENASE (Aquifexaeolicus) |
no annotation | 5 | GLY D 42GLY D 43ALA D 71ILE D 63ASN D 64 | NoneNoneNoneNAD D6686 (-4.0A)None | 1.04A | 4rtmA-3gggD:4.1 | 4rtmA-3gggD:25.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0g | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB11 (Schizosaccharomycespombe;Schizosaccharomycespombe;Schizosaccharomycespombe) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4)PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5)PF13656(RNA_pol_L_2) | 5 | GLY B 821GLY A 361SER A 472TYR B 983GLN K 3 | None | 1.02A | 4rtmA-3h0gB:undetectable | 4rtmA-3h0gB:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k55 | BETA-HEMOLYSIN (Staphylococcusaureus) |
PF03372(Exo_endo_phos) | 5 | GLY A 100GLY A 101PHE A 132ALA A 103ILE A 114 | None | 0.84A | 4rtmA-3k55A:undetectable | 4rtmA-3k55A:26.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq3 | PYRUVATEDEHYDROGENASEPHOSPHATASE 1 (Bos taurus) |
PF00481(PP2C) | 5 | GLY A 200GLY A 77ALA A 76ILE A 52ASN A 49 | None | 0.96A | 4rtmA-3mq3A:undetectable | 4rtmA-3mq3A:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n79 | PDUT (Salmonellaenterica) |
PF00936(BMC) | 5 | GLY A 134GLY A 133ILE A 99SER A 168TYR A 166 | None | 1.01A | 4rtmA-3n79A:undetectable | 4rtmA-3n79A:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nep | MALATE DEHYDROGENASE (Salinibacterruber) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY X 193GLY X 194GLY X 165ALA X 164ILE X 268 | None | 0.74A | 4rtmA-3nepX:2.8 | 4rtmA-3nepX:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qv2 | 5-CYTOSINE DNAMETHYLTRANSFERASE (Entamoebahistolytica) |
PF00145(DNA_methylase) | 5 | PHE A 12GLY A 14ILE A 38ASN A 39PRO A 80 | SAH A 323 (-4.4A)SAH A 323 (-3.6A)SAH A 323 (-4.0A)SAH A 323 (-4.8A)SAH A 323 (-4.4A) | 0.92A | 4rtmA-3qv2A:undetectable | 4rtmA-3qv2A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3red | HYDROXYNITRILE LYASE (Prunus mume) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 35GLY A 34GLY A 259ALA A 258SER A 494 | FAD A 773 (-3.4A)NoneFAD A 773 (-3.5A)FAD A 773 (-3.6A)None | 1.04A | 4rtmA-3redA:2.3 | 4rtmA-3redA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rha | PUTRESCINE OXIDASE (Paenarthrobacteraurescens) |
PF01593(Amino_oxidase) | 5 | GLY A 44GLY A 43GLY A 14ALA A 15SER A 271 | FDA A 483 (-3.1A)NoneFDA A 483 (-3.1A)NoneNone | 0.96A | 4rtmA-3rhaA:undetectable | 4rtmA-3rhaA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rju | BETA-LACTAMASE/D-ALANINECARBOXYPEPTIDASE (Yersinia pestis) |
PF00144(Beta-lactamase) | 5 | GLY A 224GLY A 225GLY A 303TYR A 309GLN A 298 | None | 0.89A | 4rtmA-3rjuA:undetectable | 4rtmA-3rjuA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u0f | BETA-KETOACYLSYNTHASE (Brucellaabortus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 186GLY A 187PHE A 184ALA A 140ASN A 154 | None | 1.03A | 4rtmA-3u0fA:undetectable | 4rtmA-3u0fA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7p | AMIDOHYDROLASEFAMILY PROTEIN (Nitratiruptorsp. SB155-2) |
PF01979(Amidohydro_1) | 5 | PHE A 353GLY A 347ALA A 346ILE A 116ASN A 59 | None | 1.04A | 4rtmA-3v7pA:undetectable | 4rtmA-3v7pA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vgl | GLUCOKINASE (Streptomycesgriseus) |
PF00480(ROK) | 5 | GLY A 260GLY A 259GLY A 302ALA A 301ILE A 9 | ANP A 325 ( 4.1A)NoneNoneNoneNone | 0.95A | 4rtmA-3vglA:undetectable | 4rtmA-3vglA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vgl | GLUCOKINASE (Streptomycesgriseus) |
PF00480(ROK) | 5 | GLY A 260GLY A 259GLY A 302ALA A 301ILE A 14 | ANP A 325 ( 4.1A)NoneNoneNoneNone | 0.99A | 4rtmA-3vglA:undetectable | 4rtmA-3vglA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpz | GLUCOKINASE (Pseudoalteromonassp. AS-131) |
PF02685(Glucokinase) | 5 | GLY A 268GLY A 269GLY A 265ALA A 261GLN A 161 | None | 0.93A | 4rtmA-3vpzA:undetectable | 4rtmA-3vpzA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrb | FLAVOPROTEIN SUBUNITOF COMPLEX II (Ascaris suum) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | GLY A 50GLY A 51GLY A 420ALA A 441ILE A 393 | FAD A 702 (-3.0A)FAD A 702 (-4.4A)FAD A 702 (-3.6A)FAD A 702 ( 4.3A)None | 0.99A | 4rtmA-3vrbA:undetectable | 4rtmA-3vrbA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wuy | NITRILASE (Synechocystissp. PCC 6803) |
PF00795(CN_hydrolase) | 5 | GLY A 271ALA A 18ILE A 255ASN A 223SER A 256 | None | 0.96A | 4rtmA-3wuyA:undetectable | 4rtmA-3wuyA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wuy | NITRILASE (Synechocystissp. PCC 6803) |
PF00795(CN_hydrolase) | 5 | GLY A 271ALA A 18ILE A 255SER A 256PRO A 265 | None | 1.02A | 4rtmA-3wuyA:undetectable | 4rtmA-3wuyA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ae0 | DIPHTHERIA TOXIN (Corynebacteriumdiphtheriae) |
PF01324(Diphtheria_R)PF02763(Diphtheria_C)PF02764(Diphtheria_T) | 5 | GLY A 75ILE A 165ASN A 166TYR A 60GLN A 184 | None | 0.99A | 4rtmA-4ae0A:undetectable | 4rtmA-4ae0A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4af1 | PEPTIDE CHAINRELEASE FACTORSUBUNIT 1 (Halobacteriumsalinarum) |
PF03463(eRF1_1)PF03464(eRF1_2)PF03465(eRF1_3) | 5 | GLY A 29PHE A 97GLY A 99ALA A 100ILE A 37 | None | 1.00A | 4rtmA-4af1A:undetectable | 4rtmA-4af1A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bvl | PHB DEPOLYMERASEPHAZ7 (Paucimonaslemoignei) |
PF01674(Lipase_2) | 5 | GLY A 163GLY A 164ALA A 258ILE A 272ASN A 273 | None | 0.74A | 4rtmA-4bvlA:undetectable | 4rtmA-4bvlA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d5g | CYCLOHEXANE-1,2-DIONE HYDROLASE (Azoarcus sp.BH72) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 429GLY A 450ALA A 453ASN A 400SER A 376 | NoneTPP A1589 (-3.3A)TPP A1589 (-3.3A)TPP A1589 (-4.3A)None | 1.02A | 4rtmA-4d5gA:undetectable | 4rtmA-4d5gA:17.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gom | DNA ADENINEMETHYLASE (Escherichiacoli) |
PF02086(MethyltransfD12) | 9 | GLY D 12PHE D 35ILE D 55ASN D 56SER D 164TYR D 165PRO D 183TYR D 184GLN D 205 | None0Y0 D 301 (-4.4A)0Y0 D 301 (-3.8A)None0Y0 D 301 (-3.6A)None0Y0 D 301 (-4.0A)0Y0 D 301 (-3.4A)0Y0 D 301 ( 4.6A) | 1.06A | 4rtmA-4gomD:38.9 | 4rtmA-4gomD:92.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gom | DNA ADENINEMETHYLASE (Escherichiacoli) |
PF02086(MethyltransfD12) | 10 | PHE D 35GLY D 37ALA D 38ILE D 55ASN D 56SER D 164TYR D 165PRO D 183TYR D 184GLN D 205 | 0Y0 D 301 (-4.4A)0Y0 D 301 ( 3.8A)None0Y0 D 301 (-3.8A)None0Y0 D 301 (-3.6A)None0Y0 D 301 (-4.0A)0Y0 D 301 (-3.4A)0Y0 D 301 ( 4.6A) | 0.33A | 4rtmA-4gomD:38.9 | 4rtmA-4gomD:92.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gpg | PROTEASE 1 (Achromobacterlyticus) |
PF00089(Trypsin) | 5 | GLY A 171GLY A 174ALA A 173SER A 233GLN A 208 | None | 1.02A | 4rtmA-4gpgA:undetectable | 4rtmA-4gpgA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7u | PYRANOSEDEHYDROGENASE (Leucoagaricusmeleagris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 515GLY A 317ILE A 296ASN A 313SER A 294 | None | 1.03A | 4rtmA-4h7uA:undetectable | 4rtmA-4h7uA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ia4 | AQUAPORIN (Spinaciaoleracea) |
PF00230(MIP) | 5 | GLY A 151GLY A 150ALA A 229ILE A 221ASN A 222 | None | 1.04A | 4rtmA-4ia4A:undetectable | 4rtmA-4ia4A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ita | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE (Synechococcussp. PCC 7002) |
PF00171(Aldedh) | 5 | GLY A 427GLY A 426GLY A 388ALA A 410GLN A 357 | NoneEDO A 515 (-4.0A)NoneEDO A 515 ( 3.7A)None | 0.91A | 4rtmA-4itaA:2.7 | 4rtmA-4itaA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv9 | TRYPTOPHAN2-MONOOXYGENASE (Pseudomonassavastanoi) |
PF01593(Amino_oxidase) | 5 | GLY A 76GLY A 75GLY A 45ALA A 46ILE A 337 | FAD A 601 (-3.1A)NoneFAD A 601 (-3.1A)NoneNone | 0.97A | 4rtmA-4iv9A:undetectable | 4rtmA-4iv9A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcl | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Paenibacillusmacerans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 5 | GLY A 524GLY A 525GLY A 528ALA A 527PRO A 500 | NoneNoneNone CL A 707 ( 4.3A)None | 0.95A | 4rtmA-4jclA:undetectable | 4rtmA-4jclA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m3c | SEED LECTIN BETACHAIN (Spatholobusparviflorus) |
PF00139(Lectin_legB) | 5 | GLY F 106GLY F 105GLY F 89ILE F 143TYR F 140 | CA F 301 ( 4.6A)NoneNoneNoneNone | 0.98A | 4rtmA-4m3cF:undetectable | 4rtmA-4m3cF:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nd4 | LACTATEDEHYDROGENASE,ADJACENT GENEENCODES PREDICTEDMALATE DEHYDROGENASE (Cryptosporidiumparvum) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 193GLY A 194GLY A 165ALA A 164SER A 188 | NoneGOL A 405 (-3.8A)NoneNAD A 401 ( 4.5A)None | 0.87A | 4rtmA-4nd4A:undetectable | 4rtmA-4nd4A:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4plh | MALATE DEHYDROGENASE (Apicomplexa) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 175GLY A 176GLY A 147ALA A 146ILE A 254 | NoneNoneNoneNAI A 403 ( 4.5A)None | 0.89A | 4rtmA-4plhA:3.5 | 4rtmA-4plhA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qfh | GLUCOSE-6-PHOSPHATEISOMERASE (Trypanosomacruzi) |
PF00342(PGI) | 5 | GLY A 207PHE A 232GLY A 205ILE A 256PRO A 213 | G6P A 700 ( 4.3A)NoneNoneNoneNone | 1.05A | 4rtmA-4qfhA:3.2 | 4rtmA-4qfhA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9n | LMO0547 PROTEIN (Listeriamonocytogenes) |
PF04198(Sugar-bind) | 5 | GLY A 263GLY A 199ILE A 137SER A 168TYR A 170 | None | 1.04A | 4rtmA-4r9nA:undetectable | 4rtmA-4r9nA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rep | GAMMA-CAROTENEDESATURASE (Nonlabensdokdonensis) |
PF01593(Amino_oxidase) | 5 | GLY A 13GLY A 12PHE A 231GLY A 37ASN A 33 | NoneFAD A 501 (-3.4A)NoneNoneFAD A 501 (-3.7A) | 0.94A | 4rtmA-4repA:2.6 | 4rtmA-4repA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rjk | ACETOLACTATESYNTHASE (Bacillussubtilis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 86GLY A 88GLY A 111ALA A 110ILE A 114 | None | 1.00A | 4rtmA-4rjkA:undetectable | 4rtmA-4rjkA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rlb | CARBAPENEM-ASSOCIATED RESISTANCE PROTEIN (Acinetobacterbaumannii) |
no annotation | 5 | GLY A 151GLY A 100ALA A 99ILE A 146TYR A 103 | None | 1.00A | 4rtmA-4rlbA:undetectable | 4rtmA-4rlbA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s28 | PHOSPHOMETHYLPYRIMIDINE SYNTHASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF01964(ThiC_Rad_SAM) | 5 | GLY A 344GLY A 345ALA A 349ILE A 295TYR A 286 | AIR A 702 (-3.6A)NoneNoneNoneAIR A 702 (-4.6A) | 0.97A | 4rtmA-4s28A:2.4 | 4rtmA-4s28A:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqo | METHANOLDEHYDROGENASEPROTEIN, LARGESUBUNIT (Methylococcuscapsulatus) |
no annotation | 5 | GLY B 210GLY B 268GLY B 203ALA B 204ILE B 180 | NoneNonePQQ B 702 (-3.1A)PQQ B 702 (-3.0A)None | 0.95A | 4rtmA-4tqoB:undetectable | 4rtmA-4tqoB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txg | CHITINASE (Chromobacteriumviolaceum) |
PF00704(Glyco_hydro_18)PF06483(ChiC) | 5 | GLY A 518GLY A 517GLY A 401ALA A 402SER A 396 | None | 0.96A | 4rtmA-4txgA:undetectable | 4rtmA-4txgA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y63 | HISTO-BLOOD GROUPABO SYSTEMTRANSFERASE (Homo sapiens) |
PF03414(Glyco_transf_6) | 5 | GLY A 266GLY A 267GLY A 230ILE A 94PRO A 321 | None | 0.96A | 4rtmA-4y63A:undetectable | 4rtmA-4y63A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cde | PROLINE DIPEPTIDASE (Xanthomonascampestris) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | GLY A 162GLY A 157ALA A 158ILE A 137TYR A 61 | None | 0.83A | 4rtmA-5cdeA:undetectable | 4rtmA-5cdeA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cju | ISOBUTYRYL-COAMUTASE FUSED (Cupriavidusmetallidurans) |
PF01642(MM_CoA_mutase)PF02310(B12-binding)PF03308(ArgK) | 5 | GLY A 216GLY A 219ALA A 220PRO A 250GLN A 51 | NoneGDP A1104 (-3.2A)GDP A1104 (-4.8A)NoneNone | 0.97A | 4rtmA-5cjuA:undetectable | 4rtmA-5cjuA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cmc | ML032222A IGLUR (Mnemiopsisleidyi) |
PF10613(Lig_chan-Glu_bd) | 5 | GLY A 142GLY A 64ALA A 65ILE A 90SER A 14 | None | 1.04A | 4rtmA-5cmcA:undetectable | 4rtmA-5cmcA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e72 | N2,N2-DIMETHYLGUANOSINETRNAMETHYLTRANSFERASE (Thermococcuskodakarensis) |
PF01170(UPF0020)PF02926(THUMP) | 6 | PHE A 187GLY A 189ALA A 190ILE A 209PRO A 256TYR A 257 | SAM A 400 (-4.7A)SAM A 400 (-3.3A)NoneSAM A 400 (-3.9A)SAM A 400 (-4.2A)None | 0.83A | 4rtmA-5e72A:12.4 | 4rtmA-5e72A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fkr | ENDO-1,4-BETA-GLUCANASE/XYLOGLUCANASE,PUTATIVE, GLY74A (Cellvibriojaponicus) |
no annotation | 5 | GLY A 295GLY A 296ILE A 289TYR A 206GLN A 269 | None | 0.87A | 4rtmA-5fkrA:undetectable | 4rtmA-5fkrA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsa | CYP51 VARIANT1 (Candidaalbicans) |
PF00067(p450) | 5 | GLY A 465GLY A 466PHE A 463ASN A 435PRO A 462 | NoneNoneHEM A 580 ( 4.5A)NoneNone | 1.04A | 4rtmA-5fsaA:undetectable | 4rtmA-5fsaA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fsg | MALTOSE-BINDINGPERIPLASMIC PROTEIN,HANTAVIRUSNUCLEOPROTEIN (Hantaanorthohantavirus) |
PF00846(Hanta_nucleocap)PF13416(SBP_bac_8) | 5 | GLY A-303ILE A-106ASN A-105TYR A-266TYR A-273 | None | 1.03A | 4rtmA-5fsgA:undetectable | 4rtmA-5fsgA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fya | PATATIN-LIKEPROTEIN, PLPD (Pseudomonasaeruginosa) |
PF01734(Patatin) | 6 | GLY A 66GLY A 67GLY A 58ALA A 163ILE A 214ASN A 213 | None | 1.23A | 4rtmA-5fyaA:undetectable | 4rtmA-5fyaA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7d | PUTRESCINEAMINOTRANSFERASE,IMMUNOGLOBULING-BINDING PROTEIN A (Escherichiacoli;Staphylococcusaureus) |
PF00202(Aminotran_3)PF02216(B) | 5 | GLY A 92GLY A 305ASN A 100SER A 72GLN A 437 | None | 1.03A | 4rtmA-5h7dA:2.1 | 4rtmA-5h7dA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hsi | PUTATIVEDECARBOXYLASE (Lactobacillusbrevis) |
PF00282(Pyridoxal_deC) | 5 | GLY A 402GLY A 401ILE A 414SER A 415TYR A 435 | None | 0.92A | 4rtmA-5hsiA:undetectable | 4rtmA-5hsiA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l46 | DIMETHYLGLYCINEDEHYDROGENASE,MITOCHONDRIAL (Homo sapiens) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 6 | GLY A 58GLY A 57GLY A 249ALA A 248ILE A 372TYR A 399 | FAD A 901 (-3.3A)FAD A 901 (-4.5A)FAD A 901 (-3.4A)FAD A 901 (-4.1A)FAD A 901 (-4.3A)None | 1.31A | 4rtmA-5l46A:2.4 | 4rtmA-5l46A:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m49 | AMINOTRANSFERASECLASS-III (Rhizobiumfreirei) |
PF00202(Aminotran_3) | 5 | GLY A 271GLY A 272GLY A 50ALA A 48SER A 247 | None | 1.01A | 4rtmA-5m49A:undetectable | 4rtmA-5m49A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m6g | BETA-GLUCOSIDASE (Saccharopolysporaerythraea) |
no annotation | 5 | GLY A 454GLY A 442ILE A 465TYR A 194GLN A 413 | None | 0.88A | 4rtmA-5m6gA:undetectable | 4rtmA-5m6gA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mzs | FERRIC ENTEROBACTINRECEPTOR (Pseudomonasaeruginosa) |
no annotation | 5 | GLY A 325GLY A 324GLY A 321ILE A 318ASN A 319 | None | 0.87A | 4rtmA-5mzsA:undetectable | 4rtmA-5mzsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wt3 | TRNA(GUANINE(37)-N1)-METHYLTRANSFERASE TRM5A (Pyrococcusabyssi) |
no annotation | 5 | PHE A 191GLY A 193ILE A 214ASN A 215PRO A 262 | MTA A 401 (-4.4A)MTA A 401 (-3.6A)MTA A 401 (-3.7A)None G C 37 ( 4.1A) | 0.83A | 4rtmA-5wt3A:0.0 | 4rtmA-5wt3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xm3 | GLUCOSEDEHYDROGENASE (Methylophagaaminisulfidivorans) |
no annotation | 5 | GLY A 213GLY A 271GLY A 206ALA A 207ILE A 183 | NoneNonePQQ A 701 (-3.7A)PQQ A 701 (-3.0A)None | 1.03A | 4rtmA-5xm3A:undetectable | 4rtmA-5xm3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b07 | FARNESYL DIPHOSPHATESYNTHASE (Choristoneurafumiferana) |
no annotation | 5 | PHE A 282GLY A 280ALA A 246ILE A 389TYR A 393 | None | 1.03A | 4rtmA-6b07A:undetectable | 4rtmA-6b07A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bka | NITRONATEMONOOXYGENASE (Cyberlindneramrakii) |
no annotation | 5 | GLY A 240GLY A 239GLY A 195ILE A 301SER A 302 | FMN A 401 (-3.4A)FMN A 401 (-3.2A)FMN A 401 (-3.7A)NoneNone | 0.98A | 4rtmA-6bkaA:undetectable | 4rtmA-6bkaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cmz | DIHYDROLIPOYLDEHYDROGENASE (Burkholderiacenocepacia) |
no annotation | 5 | GLY A 16GLY A 17GLY A 40ILE A 49SER A 51 | FAD A 502 (-3.7A)NoneNoneNoneFAD A 502 (-3.6A) | 1.05A | 4rtmA-6cmzA:2.5 | 4rtmA-6cmzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eic | MYCOBACTERIUMTUBERCULOSISMONOGLYCERIDE LIPASE (Mycobacteriumtuberculosis) |
no annotation | 5 | GLY C 112GLY C 114ALA C 136ILE C 171SER C 172 | NoneNoneSO4 C 301 ( 4.0A)MPD C 302 ( 4.6A)None | 0.94A | 4rtmA-6eicC:2.4 | 4rtmA-6eicC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 5 | GLY A 290PHE A 285GLY A 287SER A 33TYR A 283 | None | 1.02A | 4rtmA-6enxA:3.2 | 4rtmA-6enxA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fay | ODZ3 PROTEIN (Mus musculus) |
no annotation | 6 | GLY A2356GLY A2357ILE A2103ASN A2314TYR A2291GLN A2084 | None | 1.25A | 4rtmA-6fayA:undetectable | 4rtmA-6fayA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fb3 | TENEURIN-2 (Gallus gallus) |
no annotation | 6 | GLY A2441GLY A2442ILE A2188ASN A2399TYR A2376GLN A2169 | None | 1.31A | 4rtmA-6fb3A:undetectable | 4rtmA-6fb3A:undetectable |