SIMILAR PATTERNS OF AMINO ACIDS FOR 4RTB_A_SAMA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 LEU A 308
PHE A 275
LEU A 270
LEU A 226
ALA A 234
 None
 1.22A 4rtbA-1c3rA:
undetectable		 4rtbA-1c3rA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kvk MEVALONATE KINASE

(Rattus
norvegicus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 VAL A  31
LEU A 234
LEU A 331
LEU A 305
ALA A  21
 None
 1.43A 4rtbA-1kvkA:
undetectable		 4rtbA-1kvkA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3a P24: PLANT
TRANSCRIPTIONAL
REGULATOR PBF-2

(Solanum
tuberosum) 		PF08536
(Whirly) 		5 TYR A  96
VAL A 192
PHE A 134
ALA A 233
PHE A 234
 None
 1.36A 4rtbA-1l3aA:
undetectable		 4rtbA-1l3aA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mx3 C-TERMINAL BINDING
PROTEIN 1

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 CYH A 232
LEU A 217
LEU A 226
LEU A 227
ALA A 259
 None
 1.35A 4rtbA-1mx3A:
undetectable		 4rtbA-1mx3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np8 CALCIUM-DEPENDENT
PROTEASE, SMALL
SUBUNIT

(Rattus
norvegicus) 		PF13833
(EF-hand_8) 		5 CYH A  60
VAL A  44
LEU A  83
LEU A  75
ALA A  33
 None
 1.33A 4rtbA-1np8A:
undetectable		 4rtbA-1np8A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nqz COA PYROPHOSPHATASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		5 TYR A 170
VAL A 107
LEU A 189
LEU A 147
PHE A  68
 None
 1.18A 4rtbA-1nqzA:
undetectable		 4rtbA-1nqzA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q47 SEMAPHORIN 3A

(Mus musculus) 		PF01403
(Sema) 		5 CYH A 517
VAL A 439
LEU A 494
PHE A 450
LEU A  32
 None
 1.31A 4rtbA-1q47A:
undetectable		 4rtbA-1q47A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjt EPIDERMAL GROWTH
FACTOR RECEPTOR
SUBSTRATE SUBSTRATE
15, EPS15

(Mus musculus) 		PF12763
(EF-hand_4) 		5 VAL A  26
LEU A  53
LEU A  48
ALA A  81
PHE A 103
 None
 1.38A 4rtbA-1qjtA:
undetectable		 4rtbA-1qjtA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u61 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF00636
(Ribonuclease_3) 		5 VAL A 125
PHE A  64
LEU A  65
ALA A  98
PHE A  99
 None
 1.36A 4rtbA-1u61A:
undetectable		 4rtbA-1u61A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		5 LEU A 183
PHE A 234
LEU A 232
LEU A 230
ALA A 360
 None
 1.26A 4rtbA-1uhgA:
undetectable		 4rtbA-1uhgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		5 TYR A 249
LEU A 304
PHE A 253
LEU A 250
ALA A 268
 None
 1.39A 4rtbA-1wstA:
undetectable		 4rtbA-1wstA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		5 VAL A  78
LEU A  46
LEU A   3
LEU A   5
ALA A  33
 None
 1.14A 4rtbA-1xe4A:
undetectable		 4rtbA-1xe4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		5 VAL B 233
PHE B 106
LEU B  44
LEU B  40
ALA B 163
 None
 1.34A 4rtbA-1zunB:
undetectable		 4rtbA-1zunB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4x FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 3

(Salmonella
enterica) 		PF00669
(Flagellin_N) 		5 VAL A  83
LEU A 250
LYS A  72
ALA A 144
PHE A 146
 None
 1.42A 4rtbA-2d4xA:
undetectable		 4rtbA-2d4xA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dla 397AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF04104
(DNA_primase_lrg) 		5 ASN A  89
LEU A  69
PHE A  66
LEU A  63
LEU A  15
 None
 0.94A 4rtbA-2dlaA:
undetectable		 4rtbA-2dlaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		5 TYR A 233
ASN A 207
LEU A 185
LEU A 123
PHE A 226
 None
None
None
None
SAM  A 400 (-4.9A)
 1.32A 4rtbA-2f8lA:
undetectable		 4rtbA-2f8lA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gaf POLY(A) POLYMERASE
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03296
(Pox_polyA_pol)
PF12629
(Pox_polyA_pol_C)
PF12630
(Pox_polyA_pol_N) 		5 TYR D 186
ASN D 386
LEU D 237
LEU D 206
PHE D 280
 None
 1.12A 4rtbA-2gafD:
undetectable		 4rtbA-2gafD:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmn METALLO-BETA-LACTAMA
SE

(Bradyrhizobium
diazoefficiens) 		PF00753
(Lactamase_B) 		5 VAL A 188
LEU A 198
PHE A 199
LEU A  98
LEU A  96
 None
 1.15A 4rtbA-2gmnA:
undetectable		 4rtbA-2gmnA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 CYH A  91
VAL A  10
LEU A  96
LEU A 125
ALA A  89
 None
 1.28A 4rtbA-2hjsA:
undetectable		 4rtbA-2hjsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iag PROSTACYCLIN
SYNTHASE

(Homo sapiens) 		PF00067
(p450) 		5 TYR A 181
LEU A 128
LEU A 256
LEU A 246
ALA A 274
 None
 1.38A 4rtbA-2iagA:
undetectable		 4rtbA-2iagA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iee PROBABLE ABC
TRANSPORTER
EXTRACELLULAR-BINDIN
G PROTEIN YCKB

(Bacillus
subtilis) 		PF00497
(SBP_bac_3) 		5 TYR A 107
VAL A  65
LEU A 220
LEU A 228
LEU A 237
 None
 1.36A 4rtbA-2ieeA:
undetectable		 4rtbA-2ieeA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 TYR A 176
LEU A 252
LEU A 216
LEU A 173
PHE A   5
 None
 1.37A 4rtbA-2iipA:
undetectable		 4rtbA-2iipA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3c APEX NUCLEASE 1

(Danio rerio) 		PF03372
(Exo_endo_phos) 		5 TYR A 188
ASN A 134
LEU A 192
LEU A 189
ALA A 163
 None
 1.40A 4rtbA-2o3cA:
undetectable		 4rtbA-2o3cA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 VAL A 224
LEU A 234
LEU A 191
LEU A 169
ALA A 181
 None
 1.33A 4rtbA-2omvA:
undetectable		 4rtbA-2omvA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg4 UNCHARACTERIZED
PROTEIN

(Oceanicola
granulosus) 		PF13759
(2OG-FeII_Oxy_5) 		5 CYH A  35
LEU A  80
LEU A  66
LEU A  63
ALA A  39
 None
 1.32A 4rtbA-2rg4A:
undetectable		 4rtbA-2rg4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri0 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Streptococcus
mutans) 		PF01182
(Glucosamine_iso) 		5 LEU A  61
LEU A 187
LEU A 223
ALA A 229
PHE A 190
 None
 1.36A 4rtbA-2ri0A:
undetectable		 4rtbA-2ri0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 VAL A 273
ASN A 369
LEU A 372
LEU A 135
LEU A 139
 None
 1.44A 4rtbA-2wsxA:
undetectable		 4rtbA-2wsxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxz ANGIOTENSINOGEN

(Rattus
norvegicus) 		PF00079
(Serpin) 		5 TYR A 248
LEU A 243
PHE A 244
LEU A 392
LEU A 232
 None
 1.34A 4rtbA-2wxzA:
undetectable		 4rtbA-2wxzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3

(Saccharomyces
cerevisiae) 		PF15612
(WHIM1) 		5 ASN B 255
PHE B 295
LEU B 299
LEU B 302
ALA B 394
 None
 1.18A 4rtbA-2y9yB:
undetectable		 4rtbA-2y9yB:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z80 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 TYR A 189
VAL A 224
PHE A 217
LEU A 212
ALA A 183
 None
 1.43A 4rtbA-2z80A:
undetectable		 4rtbA-2z80A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 VAL A  35
LEU A  50
LEU A 102
LEU A 126
LYS A 127
 None
 1.34A 4rtbA-2z81A:
undetectable		 4rtbA-2z81A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvc UNCHARACTERIZED
PROTEIN ISM_01780

(Roseovarius
nubinhibens) 		PF13759
(2OG-FeII_Oxy_5) 		5 CYH A  35
LEU A  80
LEU A  66
LEU A  63
ALA A  39
 None
 1.26A 4rtbA-3bvcA:
undetectable		 4rtbA-3bvcA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu3 DOMAIN OF UNKNOWN
FUNCTION WITH A
CYSTATIN-LIKE FOLD

(Nostoc
punctiforme) 		PF14534
(DUF4440) 		5 LEU A 152
PHE A 149
LEU A 146
LEU A 138
ALA A 110
 None
 1.44A 4rtbA-3cu3A:
undetectable		 4rtbA-3cu3A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu3 DOMAIN OF UNKNOWN
FUNCTION WITH A
CYSTATIN-LIKE FOLD

(Nostoc
punctiforme) 		PF14534
(DUF4440) 		5 VAL A 164
PHE A 149
LEU A 146
LEU A 138
ALA A 110
 None
 1.20A 4rtbA-3cu3A:
undetectable		 4rtbA-3cu3A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TYR A 473
VAL A 315
LEU A 296
LEU A 469
LEU A 465
 L41  A 501 (-4.8A)
None
None
L41  A 501 (-3.8A)
None
 1.36A 4rtbA-3d5fA:
undetectable		 4rtbA-3d5fA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		5 VAL A 169
LEU A 188
LEU A 160
LEU A 157
ALA A  94
 None
 1.35A 4rtbA-3fdgA:
4.3		 4rtbA-3fdgA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 350
PHE A 330
LEU A 307
LEU A 280
ALA A 276
 None
 1.36A 4rtbA-3fxiA:
undetectable		 4rtbA-3fxiA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hut PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 TYR A 307
VAL A 322
LEU A  47
ALA A 302
PHE A 299
 None
 1.35A 4rtbA-3hutA:
undetectable		 4rtbA-3hutA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		5 VAL P 302
ASN P 261
LEU P 268
LEU P 272
ALA P 318
 None
 1.18A 4rtbA-3j9tP:
undetectable		 4rtbA-3j9tP:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jx9 PUTATIVE
PHOSPHOHEPTOSE
ISOMERASE

(Exiguobacterium
sibiricum) 		PF10740
(DUF2529) 		5 VAL A  26
LEU A  34
LEU A  55
ALA A 151
PHE A  83
 None
 1.33A 4rtbA-3jx9A:
undetectable		 4rtbA-3jx9A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		5 TYR A 311
VAL A 285
LEU A 333
ALA A 253
PHE A 256
 None
 1.32A 4rtbA-3kq5A:
undetectable		 4rtbA-3kq5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		5 TYR A 311
VAL A 285
LEU A 333
LEU A 307
PHE A 256
 None
 1.41A 4rtbA-3kq5A:
undetectable		 4rtbA-3kq5A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzz SNAP-TAG

(Homo sapiens) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		5 TYR A  69
ASN A 137
LEU A 102
LEU A 168
PHE A  33
 None
 1.44A 4rtbA-3kzzA:
undetectable		 4rtbA-3kzzA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 TYR A  68
VAL A 161
LEU A  48
LEU A  70
ALA A  63
 None
 1.38A 4rtbA-3m1lA:
2.5		 4rtbA-3m1lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 5 TYR I 122
VAL I 275
LEU I  70
LEU I 111
LEU I 120
 None
 1.40A 4rtbA-3opyI:
undetectable		 4rtbA-3opyI:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 ASN A  41
LEU A  80
LEU A  74
LEU A  20
ALA A  16
 None
 1.33A 4rtbA-3p41A:
undetectable		 4rtbA-3p41A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		5 VAL A 114
LEU A 151
LEU A  42
LEU A  41
PHE A  65
 None
 1.26A 4rtbA-3pjaA:
undetectable		 4rtbA-3pjaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv0 MITOCHONDRIAL ACIDIC
PROTEIN MAM33

(Saccharomyces
cerevisiae) 		PF02330
(MAM33) 		5 VAL A 234
ASN A 235
LEU A  81
LEU A  88
ALA A  97
 None
 1.23A 4rtbA-3qv0A:
undetectable		 4rtbA-3qv0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r77 PROBABLE
ISOCHORISMATASE

(Pseudomonas
fluorescens) 		PF00857
(Isochorismatase) 		5 CYH A 148
VAL A  71
LEU A 137
LEU A 172
ALA A 176
 None
 1.12A 4rtbA-3r77A:
undetectable		 4rtbA-3r77A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 VAL B1270
ASN B1267
LEU B1263
LEU B1304
LEU B1364
 None
 1.45A 4rtbA-3s4wB:
undetectable		 4rtbA-3s4wB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smv S-(-)-AZETIDINE-2-CA
RBOXYLATE HYDROLASE

(Pseudomonas sp.
AC2) 		PF13419
(HAD_2) 		5 VAL A 220
LEU A 194
LEU A   9
LEU A 111
ALA A 233
 None
 1.37A 4rtbA-3smvA:
undetectable		 4rtbA-3smvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		5 VAL A 458
LEU A 476
LEU A 416
LEU A 412
LYS A 409
 None
 1.31A 4rtbA-3sqnA:
undetectable		 4rtbA-3sqnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 ASN A 334
LEU A 338
LEU A 349
LEU A 203
PHE A 128
 None
 1.31A 4rtbA-3ttfA:
undetectable		 4rtbA-3ttfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0b OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 TYR A  64
VAL A 157
LEU A  44
LEU A  66
ALA A  59
 None
None
None
NA  A 451 ( 4.9A)
None
 1.22A 4rtbA-3u0bA:
2.1		 4rtbA-3u0bA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 TYR A 326
LEU A 301
LEU A 311
LEU A 355
ALA A 329
 None
 1.16A 4rtbA-3zhyA:
undetectable		 4rtbA-3zhyA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		5 VAL A 100
LEU A  48
PHE A  49
LEU A  83
ALA A  65
 None
 1.32A 4rtbA-4bq4A:
6.1		 4rtbA-4bq4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 VAL A  88
LEU A  81
LEU A 119
LEU A 139
PHE A 171
 None
 1.42A 4rtbA-4byfA:
undetectable		 4rtbA-4byfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 VAL P 446
ASN P 453
LEU P 454
LEU P 262
ALA P 344
 None
 1.44A 4rtbA-4crnP:
undetectable		 4rtbA-4crnP:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex6 ALNB

(Streptomyces
sp. CM020) 		PF13419
(HAD_2) 		5 TYR A  79
VAL A 197
LEU A  16
LEU A  55
LEU A  59
 None
 1.25A 4rtbA-4ex6A:
undetectable		 4rtbA-4ex6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		5 VAL A 339
LEU A 346
LEU A 300
LEU A 297
ALA A 293
 None
 1.31A 4rtbA-4fmzA:
undetectable		 4rtbA-4fmzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqz PUTATIVE PERIPLASMIC
OR EXPORTED PROTEIN

(Salmonella
enterica) 		no annotation 5 LEU A 142
PHE A  82
LEU A  78
LYS A  66
ALA A  58
 None
 1.02A 4rtbA-4gqzA:
undetectable		 4rtbA-4gqzA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		5 VAL A  81
ASN A  80
LEU A  85
LEU A  64
ALA A  55
 None
 1.41A 4rtbA-4hy3A:
undetectable		 4rtbA-4hy3A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		5 ASN A  36
LEU A  37
LEU A 145
LEU A 216
ALA A 236
 None
 1.31A 4rtbA-4ifqA:
undetectable		 4rtbA-4ifqA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		no annotation 5 TYR A  89
VAL A  31
LEU A 100
LEU A   8
PHE A  75
 None
 1.34A 4rtbA-4je3A:
undetectable		 4rtbA-4je3A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kop SINGLE-STRANDED
DNA-BINDING PROTEIN
WHY2, MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF08536
(Whirly) 		5 TYR A  58
VAL A 154
PHE A  96
ALA A 195
PHE A 196
 None
 1.39A 4rtbA-4kopA:
undetectable		 4rtbA-4kopA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		5 CYH A 182
ASN A 165
LEU A 159
LEU A 154
ALA A 180
 None
 1.42A 4rtbA-4mlgA:
undetectable		 4rtbA-4mlgA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		7 CYH A 102
ASN A 175
PHE A 202
LYS A 224
LEU A 250
ALA A 288
PHE A 364
 SF4  A 502 (-2.4A)
SAH  A 501 (-3.9A)
SAH  A 501 ( 4.6A)
SAH  A 501 ( 2.8A)
SAH  A 501 ( 3.6A)
SAH  A 501 ( 3.7A)
SAH  A 501 ( 3.8A)
 0.70A 4rtbA-4r33A:
39.7		 4rtbA-4r33A:
29.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 LEU A 273
LEU A  42
LEU A  74
ALA A  67
PHE A  64
 None
 1.15A 4rtbA-4r9oA:
8.3		 4rtbA-4r9oA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		6 TYR A  94
CYH A  95
LYS A 205
LEU A 234
LEU A 267
ALA A 270
 SAM  A 501 (-4.5A)
SF4  A 502 ( 2.7A)
SAM  A 501 (-3.3A)
None
SAM  A 501 (-4.4A)
SAM  A 501 ( 3.7A)
 1.43A 4rtbA-4rtbA:
71.5		 4rtbA-4rtbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		12 TYR A  94
CYH A  95
VAL A 132
ASN A 164
LEU A 186
PHE A 187
LYS A 205
LEU A 231
LEU A 267
LYS A 268
ALA A 270
PHE A 347
 SAM  A 501 (-4.5A)
SF4  A 502 ( 2.7A)
SAM  A 501 (-4.8A)
SAM  A 501 (-3.5A)
None
SAM  A 501 (-4.3A)
SAM  A 501 (-3.3A)
SAM  A 501 (-4.1A)
SAM  A 501 (-4.4A)
None
SAM  A 501 ( 3.7A)
SAM  A 501 (-4.8A)
 0.01A 4rtbA-4rtbA:
71.5		 4rtbA-4rtbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4h TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		5 TYR A  34
CYH A  29
VAL A 100
LEU A  72
LEU A 180
 None
 1.35A 4rtbA-4u4hA:
undetectable		 4rtbA-4u4hA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2

(Homo sapiens) 		PF01661
(Macro) 		5 TYR A 215
VAL A 152
LEU A 145
LEU A 186
LEU A 219
 None
 1.30A 4rtbA-4umlA:
undetectable		 4rtbA-4umlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1w ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 VAL A 383
LEU A 362
LEU A 356
LEU A 352
ALA A  60
 None
 1.29A 4rtbA-4w1wA:
undetectable		 4rtbA-4w1wA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wcx BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED

(Thermoanaerobacter
italicus) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		9 TYR A  96
CYH A  97
ASN A 169
LEU A 191
PHE A 192
LYS A 210
LEU A 236
LEU A 272
ALA A 275
 None
SF4  A 501 (-2.1A)
MET  A 503 (-3.2A)
None
None
SF4  A 501 (-3.3A)
None
None
None
 0.66A 4rtbA-4wcxA:
47.7		 4rtbA-4wcxA:
43.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfq SUPPRESSOR OF
STEM-LOOP PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04056
(Ssl1) 		5 LEU A 276
LEU A 264
LEU A 297
ALA A 153
PHE A 156
 None
 1.43A 4rtbA-4wfqA:
undetectable		 4rtbA-4wfqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		5 TYR A 307
ASN A 318
LEU A 208
LEU A 431
ALA A 376
 None
 1.13A 4rtbA-4wj3A:
undetectable		 4rtbA-4wj3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		5 LEU A 324
PHE A 330
LYS A  73
ALA A  75
PHE A  72
 None
 1.39A 4rtbA-4xwlA:
undetectable		 4rtbA-4xwlA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yub NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Homo sapiens) 		no annotation 5 VAL A 292
PHE A 272
LEU A 305
ALA A 338
PHE A 335
 None
 1.37A 4rtbA-4yubA:
3.1		 4rtbA-4yubA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		5 VAL A 476
LEU A 395
PHE A 394
LEU A 426
PHE A 514
 None
 1.11A 4rtbA-4zm6A:
10.1		 4rtbA-4zm6A:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		5 VAL A 373
LEU A 391
LEU A 194
LEU A 183
ALA A 178
 None
 1.43A 4rtbA-4zpjA:
undetectable		 4rtbA-4zpjA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxi TYROCIDINE
SYNTHETASE 3

(Acinetobacter
baumannii) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A1002
PHE A 999
LEU A1024
LYS A1017
ALA A1019
 None
 1.17A 4rtbA-4zxiA:
undetectable		 4rtbA-4zxiA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 VAL A  62
LEU A  43
LEU A  81
LEU A 118
PHE A 111
 None
 1.41A 4rtbA-5affA:
undetectable		 4rtbA-5affA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE

(Serratia
marcescens) 		PF00753
(Lactamase_B) 		5 VAL A  21
PHE A 172
LEU A  69
LEU A  93
ALA A  90
 None
 1.34A 4rtbA-5b1uA:
undetectable		 4rtbA-5b1uA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		5 TYR A 278
LEU A 440
LEU A 323
LEU A 277
ALA A 281
 None
 1.43A 4rtbA-5dgkA:
undetectable		 4rtbA-5dgkA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE

(Salmonella
enterica) 		PF02664
(LuxS) 		5 VAL A  73
PHE A  36
LEU A  38
LYS A 105
ALA A 107
 None
 1.03A 4rtbA-5e68A:
undetectable		 4rtbA-5e68A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 VAL X 141
LEU X  48
LEU X 182
LEU X 155
ALA X 115
 None
 1.23A 4rtbA-5eztX:
undetectable		 4rtbA-5eztX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1m PHOSPHORYLATED
PROTEIN PHOSPHATASE

(Staphylococcus
aureus) 		PF13672
(PP2C_2) 		5 VAL A 174
ASN A  83
LEU A  86
LEU A  56
LEU A  32
 None
 1.44A 4rtbA-5f1mA:
undetectable		 4rtbA-5f1mA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 ASN A 460
LEU A  45
LEU A 450
LEU A 512
ALA A 510
 None
 1.17A 4rtbA-5f56A:
undetectable		 4rtbA-5f56A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7

(Homo sapiens;
Homo sapiens) 		PF12157
(DUF3591)
PF04658
(TAFII55_N) 		5 VAL G 803
LEU G 775
LEU G 797
LEU G 784
ALA H  89
 None
 1.22A 4rtbA-5furG:
undetectable		 4rtbA-5furG:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 TYR B1431
LEU B1400
LEU B1372
ALA B1434
PHE B1377
 None
 1.09A 4rtbA-5hb4B:
undetectable		 4rtbA-5hb4B:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 LEU B 640
LEU B 363
LEU B 424
ALA B 392
PHE B 433
 None
 1.38A 4rtbA-5hccB:
undetectable		 4rtbA-5hccB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		5 VAL A 131
LEU A 164
LEU A 203
LEU A 242
ALA A 195
 None
 1.28A 4rtbA-5hjlA:
3.9		 4rtbA-5hjlA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		5 TYR A  16
VAL A 347
LEU A  24
ALA A  59
PHE A 293
 None
 1.41A 4rtbA-5j1dA:
undetectable		 4rtbA-5j1dA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 CYH A2243
VAL A1958
LEU A2123
ALA A2246
PHE A1950
 None
 1.35A 4rtbA-5nnnA:
undetectable		 4rtbA-5nnnA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oce PHOSPHATIDYLINOSITOL
MANNOSIDE
ACYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU A 185
LEU A 234
LEU A 254
ALA A 269
PHE A 272
 None
 1.29A 4rtbA-5oceA:
undetectable		 4rtbA-5oceA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj SUPPRESSOR OF
STEM-LOOP PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU 6 276
LEU 6 264
LEU 6 297
ALA 6 153
PHE 6 156
 None
 1.38A 4rtbA-5oqj6:
undetectable		 4rtbA-5oqj6:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 5 TYR A 484
VAL A 447
LEU A 491
LEU A 481
ALA A 454
 None
 1.34A 4rtbA-5xb7A:
7.7		 4rtbA-5xb7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 5 ASN A 538
LEU A 503
LEU A 525
LYS A 522
ALA A 519
 MG  A 725 (-3.7A)
None
None
None
None
 1.39A 4rtbA-5yjhA:
undetectable		 4rtbA-5yjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfz ASK1
DAD2
HSK3
SPC19

(Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation
no annotation
no annotation 		5 ASN G  41
LEU G  42
LEU I  15
LEU C  45
PHE A  36
 None
 1.44A 4rtbA-6cfzG:
undetectable		 4rtbA-6cfzG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fln E3 UBIQUITIN/ISG15
LIGASE TRIM25

(Homo sapiens) 		no annotation 5 VAL A 579
LEU A 624
PHE A 615
LEU A 502
ALA A 547
 None
 1.42A 4rtbA-6flnA:
undetectable		 4rtbA-6flnA:
undetectable