SIMILAR PATTERNS OF AMINO ACIDS FOR 4RRX_B_LURB706_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b1y | PROTEIN(BETA-AMYLASE) (Hordeum vulgare) |
PF01373(Glyco_hydro_14) | 5 | TYR A 210VAL A 137LEU A 142VAL A 112GLY A 113 | None | 1.10A | 4rrxB-1b1yA:0.0 | 4rrxB-1b1yA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3b | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermotogamaritima) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 370VAL A 345GLY A 343ALA A 342 | None | 1.08A | 4rrxB-1b3bA:0.0 | 4rrxB-1b3bA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvu | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermococcuslitoralis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | TYR A 225LEU A 372GLY A 193ALA A 194LEU A 316 | None | 1.11A | 4rrxB-1bvuA:undetectable | 4rrxB-1bvuA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bvu | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermococcuslitoralis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 372VAL A 347GLY A 345ALA A 344 | None | 1.02A | 4rrxB-1bvuA:undetectable | 4rrxB-1bvuA:20.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | TYR A 348VAL A 349LEU A 352TYR A 355LEU A 384TYR A 385TRP A 387GLY A 526ALA A 527LEU A 531 | NoneSCL A 700 ( 4.6A)SCL A 700 ( 4.8A)SCL A 700 (-4.3A)NoneNoneNoneSCL A 700 ( 4.0A)SCL A 700 (-2.9A)OAS A 530 (-4.1A) | 0.67A | 4rrxB-1ebvA:32.4 | 4rrxB-1ebvA:64.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ga8 | GALACTOSYLTRANSFERASE LGTC (Neisseriameningitidis) |
PF01501(Glyco_transf_8) | 5 | LEU A 192TRP A 164VAL A 200GLY A 126ALA A 127 | None | 1.12A | 4rrxB-1ga8A:0.0 | 4rrxB-1ga8A:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gtm | GLUTAMATEDEHYDROGENASE (Pyrococcusfuriosus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | VAL A 95LEU A 373VAL A 348GLY A 346ALA A 345 | None | 1.08A | 4rrxB-1gtmA:0.9 | 4rrxB-1gtmA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jct | GLUCARATEDEHYDRATASE (Escherichiacoli) |
PF13378(MR_MLE_C) | 5 | VAL A 132LEU A 136LEU A 84TYR A 80ALA A 118 | None | 1.06A | 4rrxB-1jctA:undetectable | 4rrxB-1jctA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ks8 | ENDO-B-1,4-GLUCANASE (Nasutitermestakasagoensis) |
PF00759(Glyco_hydro_9) | 5 | VAL A 216LEU A 251VAL A 257GLY A 259LEU A 264 | None | 1.12A | 4rrxB-1ks8A:0.8 | 4rrxB-1ks8A:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rrv | GLYCOSYLTRANSFERASEGTFD (Amycolatopsisorientalis) |
PF03033(Glyco_transf_28) | 5 | VAL A 3LEU A 5LEU A 195ALA A 392LEU A 396 | VAL A 3 ( 0.6A)LEU A 5 ( 0.6A)LEU A 195 ( 0.6A)ALA A 392 ( 0.0A)LEU A 396 ( 0.6A) | 1.10A | 4rrxB-1rrvA:0.0 | 4rrxB-1rrvA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rzm | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Thermotogamaritima) |
PF00793(DAHP_synth_1) | 6 | VAL A 268LEU A 329VAL A 290ALA A 286SER A 284LEU A 283 | None | 1.41A | 4rrxB-1rzmA:undetectable | 4rrxB-1rzmA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1taq | TAQ DNA POLYMERASE (Thermusaquaticus) |
PF00476(DNA_pol_A)PF01367(5_3_exonuc)PF02739(5_3_exonuc_N)PF09281(Taq-exonuc) | 6 | LEU A 30VAL A 44GLY A 46ALA A 48SER A 50LEU A 51 | None | 1.22A | 4rrxB-1taqA:2.0 | 4rrxB-1taqA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umf | CHORISMATE SYNTHASE (Helicobacterpylori) |
PF01264(Chorismate_synt) | 5 | LEU A 341VAL A 133GLY A 136ALA A 137LEU A 38 | None | 1.09A | 4rrxB-1umfA:undetectable | 4rrxB-1umfA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | LEU A 74GLY A 8ALA A 9SER A 34LEU A 55 | None | 0.94A | 4rrxB-1vknA:undetectable | 4rrxB-1vknA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z5x | ULTRASPIRACLEPROTEIN (USP) AHOMOLOGUE OF RXR (Bemisia tabaci) |
PF00104(Hormone_recep) | 5 | LEU U 471GLY U 347ALA U 346SER U 349LEU U 388 | None | 1.01A | 4rrxB-1z5xU:undetectable | 4rrxB-1z5xU:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a0u | INITIATION FACTOR 2B (Leishmaniamajor) |
PF01008(IF-2B) | 5 | VAL A 179TYR A 294GLY A 163ALA A 164LEU A 168 | None | 1.05A | 4rrxB-2a0uA:undetectable | 4rrxB-2a0uA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c49 | SUGAR KINASE MJ0406 (Methanocaldococcusjannaschii) |
PF00294(PfkB) | 5 | TYR A 77LEU A 78GLY A 43ALA A 15LEU A 16 | NoneNoneADN A1301 (-3.3A)ADN A1301 (-3.6A)None | 1.10A | 4rrxB-2c49A:undetectable | 4rrxB-2c49A:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dst | HYPOTHETICAL PROTEINTTHA1544 (Thermusthermophilus) |
no annotation | 5 | LEU A 26LEU A 9VAL A 70GLY A 72ALA A 71 | None | 0.98A | 4rrxB-2dstA:undetectable | 4rrxB-2dstA:11.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | TYR A 238LEU A 74GLY A 290ALA A 289LEU A 223 | None | 1.05A | 4rrxB-2elcA:undetectable | 4rrxB-2elcA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | TYR A 238LEU A 74GLY A 290ALA A 289LEU A 285 | None | 0.93A | 4rrxB-2elcA:undetectable | 4rrxB-2elcA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2elc | ANTHRANILATEPHOSPHORIBOSYLTRANSFERASE (Thermusthermophilus) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N) | 5 | VAL A 215TYR A 238LEU A 74GLY A 290ALA A 289 | None | 0.86A | 4rrxB-2elcA:undetectable | 4rrxB-2elcA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fef | HYPOTHETICAL PROTEINPA2201 (Pseudomonasaeruginosa) |
PF08929(DUF1911) | 5 | LEU A 263LEU A 153GLY A 185ALA A 186LEU A 191 | None | 1.08A | 4rrxB-2fefA:undetectable | 4rrxB-2fefA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fiy | PROTEIN FDHE HOMOLOG (Pseudomonasaeruginosa) |
PF04216(FdhE) | 5 | LEU A 125LEU A 140GLY A 157ALA A 158LEU A 55 | None | 1.11A | 4rrxB-2fiyA:undetectable | 4rrxB-2fiyA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk9 | PHOSPHATIDYLINOSITOL-4-PHOSPHATE5-KINASE, TYPE II,GAMMA (Homo sapiens) |
PF01504(PIP5K) | 5 | TYR A 122LEU A 126TYR A 189GLY A 54SER A 58 | None | 1.11A | 4rrxB-2gk9A:undetectable | 4rrxB-2gk9A:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i34 | ACID PHOSPHATASE (Bacillusanthracis) |
PF03767(Acid_phosphat_B) | 5 | VAL A 70LEU A 71GLY A 142ALA A 143LEU A 110 | None | 1.01A | 4rrxB-2i34A:undetectable | 4rrxB-2i34A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogs | THERMOSTABLECARBOXYLESTERASEEST50 (Geobacillusstearothermophilus) |
PF00135(COesterase) | 5 | LEU A 227LEU A 218GLY A 201SER A 205LEU A 206 | LEU A 227 ( 0.6A)LEU A 218 ( 0.6A)GLY A 201 ( 0.0A)SER A 205 ( 0.0A)LEU A 206 ( 0.6A) | 1.07A | 4rrxB-2ogsA:undetectable | 4rrxB-2ogsA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2or0 | HYDROXYLASE (Rhodococcusjostii) |
PF08028(Acyl-CoA_dh_2) | 5 | LEU A 36LEU A 5VAL A 64GLY A 66ALA A 68 | None | 0.99A | 4rrxB-2or0A:undetectable | 4rrxB-2or0A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pff | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00106(adh_short)PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU A 679TYR A 753LEU A 909ALA A 820LEU A 862 | None | 1.01A | 4rrxB-2pffA:undetectable | 4rrxB-2pffA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppl | PANCREATICLIPASE-RELATEDPROTEIN 1 (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 5 | LEU A 209VAL A 176GLY A 178ALA A 180SER A 182 | NoneNone CA A 478 ( 4.9A)NoneNone | 1.00A | 4rrxB-2pplA:undetectable | 4rrxB-2pplA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r48 | PHOSPHOTRANSFERASESYSTEM (PTS)MANNOSE-SPECIFICENZYME IIBCACOMPONENT (Bacillussubtilis) |
PF02302(PTS_IIB) | 5 | VAL A 67VAL A 82GLY A 81ALA A 62SER A 79 | None | 1.06A | 4rrxB-2r48A:undetectable | 4rrxB-2r48A:12.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v4j | SULFITE REDUCTASE,DISSIMILATORY-TYPESUBUNIT ALPHA (Desulfovibriovulgaris) |
PF01077(NIR_SIR)PF03460(NIR_SIR_ferr) | 5 | TYR A 114TYR A 76VAL A 102GLY A 165ALA A 103 | None | 1.12A | 4rrxB-2v4jA:undetectable | 4rrxB-2v4jA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wua | ACETOACETYL COATHIOLASE (Helianthusannuus) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | TYR A 56VAL A 80LEU A 301GLY A 160ALA A 161 | None | 1.12A | 4rrxB-2wuaA:undetectable | 4rrxB-2wuaA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xec | PUTATIVE MALEATEISOMERASE (Nocardiafarcinica) |
no annotation | 5 | LEU A 158VAL A 174ALA A 178SER A 180LEU A 181 | None | 0.91A | 4rrxB-2xecA:undetectable | 4rrxB-2xecA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xn8 | PUTATIVE CYTOCHROMEP450 125 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | VAL A 313LEU A 415VAL A 267GLY A 269ALA A 268 | HEM A1434 ( 4.9A)NoneNoneHEM A1434 (-3.3A)HEM A1434 (-3.5A) | 0.97A | 4rrxB-2xn8A:undetectable | 4rrxB-2xn8A:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yib | RNA-DIRECTED RNAPOLYMERASE (Infectiouspancreaticnecrosis virus) |
PF04197(Birna_RdRp) | 5 | VAL D 611LEU D 653GLY D 603ALA D 604LEU D 593 | None | 1.07A | 4rrxB-2yibD:undetectable | 4rrxB-2yibD:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bhn | THIJ/PFPI DOMAINPROTEIN (Shewanellaloihica) |
PF01965(DJ-1_PfpI) | 5 | VAL A 64LEU A 66LEU A 139VAL A 158LEU A 165 | None | 1.11A | 4rrxB-3bhnA:undetectable | 4rrxB-3bhnA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fz0 | NUCLEOSIDEHYDROLASE, PUTATIVE (Trypanosomabrucei) |
PF01156(IU_nuc_hydro) | 5 | LEU A 191TRP A 196VAL A 189GLY A 187ALA A 186 | None | 1.08A | 4rrxB-3fz0A:undetectable | 4rrxB-3fz0A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5p | NUCLEOPORIN NUP170 (Saccharomycescerevisiae) |
PF03177(Nucleoporin_C) | 5 | LEU A1307VAL A1268GLY A1270ALA A1269LEU A1229 | None | 1.02A | 4rrxB-3i5pA:undetectable | 4rrxB-3i5pA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2z | BIRA BIFUNCTIONALPROTEIN (Mycobacteriumtuberculosis) |
PF02237(BPL_C)PF03099(BPL_LplA_LipB) | 5 | LEU A 208LEU A 126GLY A 106ALA A 105LEU A 194 | None | 1.02A | 4rrxB-3l2zA:undetectable | 4rrxB-3l2zA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7z | PROBABLE EXOSOMECOMPLEX EXONUCLEASE2 (Sulfolobussolfataricus) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | LEU A 189LEU A 142VAL A 162ALA A 163LEU A 44 | None | 1.01A | 4rrxB-3l7zA:undetectable | 4rrxB-3l7zA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lg5 | EPI-ISOZIZAENESYNTHASE (Streptomycescoelicolor) |
no annotation | 5 | LEU A 54VAL A 139GLY A 141ALA A 143SER A 145 | None | 0.94A | 4rrxB-3lg5A:0.6 | 4rrxB-3lg5A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ljp | CHOLINE OXIDASE (Arthrobacterglobiformis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | VAL A 497LEU A 42VAL A 28GLY A 25ALA A 24 | NoneNoneNoneNoneFDA A 547 (-3.8A) | 1.11A | 4rrxB-3ljpA:undetectable | 4rrxB-3ljpA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq3 | PYRUVATEDEHYDROGENASEPHOSPHATASE 1 (Bos taurus) |
PF00481(PP2C) | 5 | LEU A 88LEU A 141ALA A 93SER A 95LEU A 96 | None | 1.02A | 4rrxB-3mq3A:undetectable | 4rrxB-3mq3A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvu | TENA FAMILYTRANSCRIPTIONALREGULATOR (Ruegeria sp.TM1040) |
PF03070(TENA_THI-4) | 5 | LEU A 62VAL A 121GLY A 125ALA A 124SER A 127 | NoneNoneNoneEDO A 235 (-4.3A)None | 1.09A | 4rrxB-3mvuA:undetectable | 4rrxB-3mvuA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxl | GLUCARATEDEHYDRATASE (Burkholderialata) |
PF13378(MR_MLE_C) | 5 | VAL A 152LEU A 156LEU A 88TYR A 84ALA A 138 | None | 1.09A | 4rrxB-3nxlA:undetectable | 4rrxB-3nxlA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4y | CALCIUM-DEPENDENTPROTEIN KINASE 3 (Plasmodiumvivax) |
PF13499(EF-hand_7)PF13833(EF-hand_8) | 5 | LEU A 113LEU A 64GLY A 80SER A 84LEU A 86 | None | 1.04A | 4rrxB-3o4yA:undetectable | 4rrxB-3o4yA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pwz | SHIKIMATEDEHYDROGENASE 3 (Pseudomonasputida) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | TYR A 212VAL A 186LEU A 214GLY A 103ALA A 135 | None | 1.06A | 4rrxB-3pwzA:undetectable | 4rrxB-3pwzA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzu | ENDOGLUCANASE (Bacillussubtilis) |
PF00150(Cellulase) | 5 | VAL A 74LEU A 79VAL A 126ALA A 93LEU A 67 | None | 1.07A | 4rrxB-3pzuA:undetectable | 4rrxB-3pzuA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rr1 | PUTATIVED-GALACTONATEDEHYDRATASE (Ralstoniapickettii) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 288LEU A 18GLY A 85ALA A 84SER A 81 | None | 0.91A | 4rrxB-3rr1A:undetectable | 4rrxB-3rr1A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t0p | DNA POLYMERASE III,BETA SUBUNIT ([Eubacterium]rectale) |
PF00712(DNA_pol3_beta)PF02767(DNA_pol3_beta_2)PF02768(DNA_pol3_beta_3) | 5 | TYR A 117LEU A 34GLY A 65ALA A 37SER A 38 | None | 0.94A | 4rrxB-3t0pA:undetectable | 4rrxB-3t0pA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t33 | G PROTEIN COUPLEDRECEPTOR (Arabidopsisthaliana) |
PF05147(LANC_like) | 5 | VAL A 59VAL A 79GLY A 81ALA A 83LEU A 86 | None | 1.12A | 4rrxB-3t33A:undetectable | 4rrxB-3t33A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tpa | HEME-BINDING PROTEINA (Glaesserellaparasuis) |
PF00496(SBP_bac_5) | 5 | VAL A 97VAL A 44GLY A 56ALA A 58LEU A 74 | None | 1.12A | 4rrxB-3tpaA:undetectable | 4rrxB-3tpaA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw2 | PHOSPHOGLUCOMUTASE/PHOSPHOMANNOMUTASEFAMILY PROTEIN (Burkholderiathailandensis) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | TYR A 338TRP A 337VAL A 82ALA A 86LEU A 91 | None | 1.11A | 4rrxB-3uw2A:undetectable | 4rrxB-3uw2A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wl1 | CHITINASE (Ostriniafurnacalis) |
PF00704(Glyco_hydro_18) | 6 | TYR A 30LEU A 367VAL A 267GLY A 368ALA A 369LEU A 393 | NAG A 501 (-3.8A)NoneNoneNoneNoneNone | 1.33A | 4rrxB-3wl1A:undetectable | 4rrxB-3wl1A:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bb9 | GLUCOKINASEREGULATORY PROTEIN (Homo sapiens) |
no annotation | 5 | LEU A 53VAL A 489GLY A 492ALA A 493LEU A 497 | None | 1.01A | 4rrxB-4bb9A:undetectable | 4rrxB-4bb9A:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxi | ACCESSORY GENEREGULATOR PROTEIN C (Staphylococcusaureus) |
PF14501(HATPase_c_5) | 5 | VAL A 425LEU A 296GLY A 334SER A 332LEU A 400 | None | 1.03A | 4rrxB-4bxiA:undetectable | 4rrxB-4bxiA:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czp | EXTRALONG MANGANESEPEROXIDASE (Gelatoporiasubvermispora) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | VAL A 28VAL A 112GLY A 110ALA A 109LEU A 90 | None | 1.06A | 4rrxB-4czpA:undetectable | 4rrxB-4czpA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dwq | TRNA-SPLICING LIGASERTCB (Pyrococcushorikoshii) |
PF01139(RtcB) | 5 | VAL A 147LEU A 148GLY A 191ALA A 192LEU A 139 | None | 1.09A | 4rrxB-4dwqA:undetectable | 4rrxB-4dwqA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h4c | 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATEREDUCTASE (Escherichiacoli) |
PF02401(LYTB) | 5 | LEU A 231VAL A 220GLY A 267ALA A 270SER A 269 | NoneNoneNoneNone10D A 402 (-2.7A) | 1.10A | 4rrxB-4h4cA:undetectable | 4rrxB-4h4cA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hka | TRYPTOPHAN2,3-DIOXYGENASE (Drosophilamelanogaster) |
PF03301(Trp_dioxygenase) | 5 | VAL A 189LEU A 199GLY A 275ALA A 276LEU A 295 | None | 0.94A | 4rrxB-4hkaA:undetectable | 4rrxB-4hkaA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hn8 | D-GLUCARATEDEHYDRATASE (Pseudomonasmendocina) |
PF13378(MR_MLE_C) | 5 | VAL A 149LEU A 153LEU A 86TYR A 82ALA A 135 | None | 1.06A | 4rrxB-4hn8A:undetectable | 4rrxB-4hn8A:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hr3 | PUTATIVE ACYL-COADEHYDROGENASE (Mycobacteroidesabscessus) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | VAL A 103LEU A 56LEU A 32VAL A 27SER A 97 | None | 1.12A | 4rrxB-4hr3A:undetectable | 4rrxB-4hr3A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4is2 | BILE ACID 3-ALPHAHYDROXYSTEROIDDEHYDROGENASE ([Clostridium]scindens) |
PF00106(adh_short) | 5 | VAL A 120LEU A 228TYR A 225VAL A 182GLY A 184 | None | 1.03A | 4rrxB-4is2A:undetectable | 4rrxB-4is2A:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9u | TRK SYSTEM POTASSIUMUPTAKE PROTEIN TRKH (Vibrioparahaemolyticus) |
PF02386(TrkH) | 5 | VAL A 79GLY A 81ALA A 83SER A 85LEU A 86 | None | 0.76A | 4rrxB-4j9uA:2.9 | 4rrxB-4j9uA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lc9 | GLUCOKINASEREGULATORY PROTEIN (Rattusnorvegicus) |
no annotation | 5 | LEU A 53VAL A 489GLY A 492ALA A 493LEU A 497 | None | 1.01A | 4rrxB-4lc9A:2.3 | 4rrxB-4lc9A:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | LEU A 233VAL A 265GLY A 268SER A 272LEU A 273 | NoneNAD A 503 (-3.6A)NoneNoneNone | 0.86A | 4rrxB-4lvcA:undetectable | 4rrxB-4lvcA:20.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 11 | TYR A 349VAL A 350LEU A 353TYR A 356LEU A 385TYR A 386TRP A 388VAL A 524GLY A 527ALA A 528LEU A 532 | NoneIBP A 601 (-4.3A)IBP A 601 ( 4.7A)IBP A 601 (-4.5A)NoneIBP A 601 (-4.8A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.9A)IBP A 601 (-3.4A)IBP A 601 ( 4.9A) | 0.62A | 4rrxB-4ph9A:37.1 | 4rrxB-4ph9A:99.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 10 | TYR A 349VAL A 350LEU A 353TYR A 356TYR A 386TRP A 388VAL A 524ALA A 528SER A 531LEU A 532 | NoneIBP A 601 (-4.3A)IBP A 601 ( 4.7A)IBP A 601 (-4.5A)IBP A 601 (-4.8A)NoneIBP A 601 ( 4.0A)IBP A 601 (-3.4A)IBP A 601 ( 3.3A)IBP A 601 ( 4.9A) | 0.73A | 4rrxB-4ph9A:37.1 | 4rrxB-4ph9A:99.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pw8 | TRYPTOPHAN2,3-DIOXYGENASE (Homo sapiens) |
PF03301(Trp_dioxygenase) | 5 | VAL A 205LEU A 215GLY A 291ALA A 292LEU A 311 | None | 0.91A | 4rrxB-4pw8A:undetectable | 4rrxB-4pw8A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0c | VIRULENCE SENSORPROTEIN BVGS (Bordetellapertussis) |
PF00497(SBP_bac_3) | 5 | VAL A 313GLY A 331ALA A 334SER A 333LEU A 337 | None | 1.09A | 4rrxB-4q0cA:undetectable | 4rrxB-4q0cA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7z | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF00493(MCM) | 5 | LEU A 871TYR A 874VAL A 283ALA A 301LEU A 302 | None | 0.98A | 4rrxB-4r7zA:undetectable | 4rrxB-4r7zA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1q | U14 PROTEIN (Humanbetaherpesvirus6B) |
PF04637(Herpes_pp85) | 5 | LEU A 447VAL A 434GLY A 437ALA A 438SER A 441 | None | 0.97A | 4rrxB-5b1qA:undetectable | 4rrxB-5b1qA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bz4 | BETA-KETOTHIOLASE (Mycolicibacteriumsmegmatis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | VAL A 240LEU A 234GLY A 253ALA A 252SER A 255 | None | 1.05A | 4rrxB-5bz4A:undetectable | 4rrxB-5bz4A:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cbk | SHHTL5 (Strigahermonthica) |
PF12697(Abhydrolase_6) | 5 | LEU A 77VAL A 103GLY A 101ALA A 102SER A 98 | None | 0.97A | 4rrxB-5cbkA:undetectable | 4rrxB-5cbkA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cqf | L-LYSINE6-MONOOXYGENASE (Pseudomonassyringae groupgenomosp. 3) |
PF13434(K_oxygenase) | 5 | VAL A 162TYR A 46GLY A 417ALA A 420LEU A 423 | None | 1.11A | 4rrxB-5cqfA:undetectable | 4rrxB-5cqfA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3i | HISTIDINE--TRNALIGASE (Acinetobacterbaumannii) |
PF03129(HGTP_anticodon)PF13393(tRNA-synt_His) | 5 | LEU A 43TYR A 109GLY A 89ALA A 88LEU A 293 | None | 1.05A | 4rrxB-5e3iA:undetectable | 4rrxB-5e3iA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evl | BETA-LACTAMASE (Chromobacteriumviolaceum) |
PF00144(Beta-lactamase) | 5 | TYR A 235LEU A 183GLY A 76ALA A 251SER A 255 | None | 1.05A | 4rrxB-5evlA:undetectable | 4rrxB-5evlA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fgl | NICR (Pseudomonasputida) |
PF00440(TetR_N) | 5 | VAL A 111LEU A 229VAL A 177GLY A 180ALA A 181 | None | 1.01A | 4rrxB-5fglA:undetectable | 4rrxB-5fglA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g1d | SYNTENIN-1 (Rattusnorvegicus) |
PF00595(PDZ) | 5 | LEU A 131VAL A 143GLY A 128ALA A 149LEU A 119 | None | 1.10A | 4rrxB-5g1dA:undetectable | 4rrxB-5g1dA:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ggy | IRON(III) ABCTRANSPORTER,PERIPLASMICIRON-COMPOUND-BINDING PROTEIN (Vibrio cholerae) |
PF01497(Peripla_BP_2) | 5 | VAL A 67LEU A 113VAL A 96GLY A 76ALA A 77 | None | 1.09A | 4rrxB-5ggyA:undetectable | 4rrxB-5ggyA:19.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 12 | TYR A 348VAL A 349LEU A 352TYR A 355LEU A 384TYR A 385TRP A 387VAL A 523GLY A 526ALA A 527SER A 530LEU A 531 | NoneID8 A 601 (-3.9A)ID8 A 601 (-4.1A)ID8 A 601 (-3.8A)ID8 A 601 ( 4.8A)ID8 A 601 ( 3.5A)COH A 602 (-4.5A)ID8 A 601 (-3.6A)ID8 A 601 (-3.5A)ID8 A 601 (-3.5A)ID8 A 601 (-2.7A)ID8 A 601 (-3.5A) | 0.54A | 4rrxB-5ikrA:62.0 | 4rrxB-5ikrA:87.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5inf | CARBOXYL TRANSFERASE (Streptomycesambofaciens) |
PF01039(Carboxyl_trans) | 5 | LEU A 512VAL A 371ALA A 336SER A 334LEU A 327 | None | 1.12A | 4rrxB-5infA:undetectable | 4rrxB-5infA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfm | ALDEHYDEDEHYDROGENASE (Rhodopseudomonaspalustris) |
PF00171(Aldedh) | 5 | VAL A 205LEU A 244VAL A 120GLY A 122LEU A 128 | None | 0.91A | 4rrxB-5jfmA:undetectable | 4rrxB-5jfmA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kkg | ANCMT E72A (syntheticconstruct) |
PF04587(ADP_PFK_GK) | 5 | LEU A 304TYR A 301GLY A 320ALA A 321LEU A 325 | None | 1.02A | 4rrxB-5kkgA:undetectable | 4rrxB-5kkgA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lc5 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN4 (Bos taurus) |
PF00361(Proton_antipo_M)PF01059(Oxidored_q5_N) | 5 | LEU M 14VAL M 25ALA M 29SER M 31LEU M 32 | None | 1.06A | 4rrxB-5lc5M:undetectable | 4rrxB-5lc5M:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | VAL A4309LEU A4312TRP A4320GLY A4152ALA A4155 | None | 1.00A | 4rrxB-5nugA:undetectable | 4rrxB-5nugA:8.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5od2 | BIFUNCTIONALADP-SPECIFICGLUCOKINASE/PHOSPHOFRUCTOKINASE (Methanocaldococcusjannaschii) |
no annotation | 5 | LEU A 315TYR A 312GLY A 331ALA A 332LEU A 336 | None | 0.95A | 4rrxB-5od2A:undetectable | 4rrxB-5od2A:8.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tii | 3-OXOACYL-ACPREDUCTASE (unculturedbacterium) |
PF13561(adh_short_C2) | 5 | VAL A 92VAL A 225GLY A 227ALA A 226LEU A 29 | None | 1.10A | 4rrxB-5tiiA:undetectable | 4rrxB-5tiiA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tnx | ALCOHOLDEHYDROGENASEZINC-BINDING DOMAINPROTEIN (Burkholderiaambifaria) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | TYR A 110GLY A 320ALA A 184SER A 188LEU A 189 | None | 0.89A | 4rrxB-5tnxA:undetectable | 4rrxB-5tnxA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tul | TETRACYCLINEDESTRUCTASE TET(55) (unculturedbacterium) |
PF01494(FAD_binding_3) | 5 | TYR A 292LEU A 32GLY A 16ALA A 15SER A 13 | NoneNoneNonePO4 A 401 (-3.5A)PO4 A 401 (-3.5A) | 1.11A | 4rrxB-5tulA:undetectable | 4rrxB-5tulA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v3n | MONOPOLIN COMPLEXSUBUNIT CSM1 (Saccharomycescerevisiae) |
PF12539(Csm1) | 5 | TYR A 156TYR A 118ALA A 176SER A 178LEU A 179 | None | 1.12A | 4rrxB-5v3nA:undetectable | 4rrxB-5v3nA:14.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veb | CADHERIN-6 (Homo sapiens) |
PF00028(Cadherin) | 5 | VAL X 568LEU X 527LEU X 550GLY X 548ALA X 547 | None | 1.10A | 4rrxB-5vebX:undetectable | 4rrxB-5vebX:10.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vym | BETA-GALACTOSIDASEBGAB (Bifidobacteriumadolescentis) |
PF08532(Glyco_hydro_42M) | 5 | LEU A 119TYR A 107GLY A 109ALA A 110LEU A 69 | None | 0.91A | 4rrxB-5vymA:undetectable | 4rrxB-5vymA:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4b | ADENOSYLHOMOCYSTEINASE (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | VAL A 273LEU A 192GLY A 227ALA A 229LEU A 232 | None | 1.12A | 4rrxB-5w4bA:undetectable | 4rrxB-5w4bA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wy3 | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
no annotation | 5 | VAL A 308LEU A 278GLY A 284ALA A 283LEU A 335 | None | 0.95A | 4rrxB-5wy3A:undetectable | 4rrxB-5wy3A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xao | UNCHARACTERIZEDPROTEIN (Parastagonosporanodorum) |
PF01266(DAO) | 5 | TYR A 170VAL A 167LEU A 171GLY A 382LEU A 378 | None | 1.10A | 4rrxB-5xaoA:undetectable | 4rrxB-5xaoA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yem | CATALASE (Mycothermusthermophilus) |
no annotation | 5 | LEU A 564VAL A 610GLY A 612ALA A 613LEU A 616 | None | 1.10A | 4rrxB-5yemA:undetectable | 4rrxB-5yemA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ckg | D-GLYCERATE 3-KINASE (Cryptococcusneoformans) |
no annotation | 5 | LEU A 68LEU A 73GLY A 98ALA A 97LEU A 219 | None | 1.07A | 4rrxB-6ckgA:undetectable | 4rrxB-6ckgA:7.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d79 | SULFATE TRANSPORTERCYSZ (Pseudomonasfragi) |
no annotation | 5 | VAL A 28LEU A 103LEU A 235GLY A 15LEU A 20 | None | 0.97A | 4rrxB-6d79A:undetectable | 4rrxB-6d79A:9.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | LEU C1098VAL C1143GLY C1146SER C1150LEU C1151 | None | 0.97A | 4rrxB-6en4C:undetectable | 4rrxB-6en4C:10.97 |