SIMILAR PATTERNS OF AMINO ACIDS FOR 4RRX_A_LURA706_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		5 TYR A 210
VAL A 137
LEU A 142
VAL A 112
GLY A 113
 None
 1.09A 4rrxA-1b1yA:
0.0		 4rrxA-1b1yA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 370
VAL A 345
GLY A 343
ALA A 342
 None
 1.09A 4rrxA-1b3bA:
undetectable		 4rrxA-1b3bA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 372
VAL A 347
GLY A 345
ALA A 344
 None
 1.01A 4rrxA-1bvuA:
undetectable		 4rrxA-1bvuA:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 TYR A 348
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.67A 4rrxA-1ebvA:
57.7		 4rrxA-1ebvA:
64.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga8 GALACTOSYL
TRANSFERASE LGTC

(Neisseria
meningitidis) 		PF01501
(Glyco_transf_8) 		5 LEU A 192
TRP A 164
VAL A 200
GLY A 126
ALA A 127
 None
 1.12A 4rrxA-1ga8A:
0.0		 4rrxA-1ga8A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gtm GLUTAMATE
DEHYDROGENASE

(Pyrococcus
furiosus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 VAL A  95
LEU A 373
VAL A 348
GLY A 346
ALA A 345
 None
 1.08A 4rrxA-1gtmA:
0.7		 4rrxA-1gtmA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A  43
TYR A 107
GLY A  87
ALA A  86
LEU A 291
 None
 0.97A 4rrxA-1httA:
0.0		 4rrxA-1httA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		5 VAL A 132
LEU A 136
LEU A  84
TYR A  80
ALA A 118
 None
 1.01A 4rrxA-1jctA:
undetectable		 4rrxA-1jctA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		5 VAL A 216
LEU A 251
VAL A 257
GLY A 259
LEU A 264
 None
 1.11A 4rrxA-1ks8A:
0.0		 4rrxA-1ks8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrv GLYCOSYLTRANSFERASE
GTFD

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 VAL A   3
LEU A   5
LEU A 195
ALA A 392
LEU A 396
 VAL  A   3 ( 0.6A)
LEU  A   5 ( 0.6A)
LEU  A 195 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 396 ( 0.6A)
 1.12A 4rrxA-1rrvA:
undetectable		 4rrxA-1rrvA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		6 VAL A 268
LEU A 329
VAL A 290
ALA A 286
SER A 284
LEU A 283
 None
 1.40A 4rrxA-1rzmA:
undetectable		 4rrxA-1rzmA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		6 LEU A  30
VAL A  44
GLY A  46
ALA A  48
SER A  50
LEU A  51
 None
 1.22A 4rrxA-1taqA:
undetectable		 4rrxA-1taqA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		5 LEU A 341
VAL A 133
GLY A 136
ALA A 137
LEU A  38
 None
 1.10A 4rrxA-1umfA:
undetectable		 4rrxA-1umfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  74
GLY A   8
ALA A   9
SER A  34
LEU A  55
 None
 0.96A 4rrxA-1vknA:
undetectable		 4rrxA-1vknA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 LEU U 471
GLY U 347
ALA U 346
SER U 349
LEU U 388
 None
 1.03A 4rrxA-1z5xU:
undetectable		 4rrxA-1z5xU:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		5 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.10A 4rrxA-2a0uA:
undetectable		 4rrxA-2a0uA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c49 SUGAR KINASE MJ0406

(Methanocaldococcus
jannaschii) 		PF00294
(PfkB) 		5 TYR A  77
LEU A  78
GLY A  43
ALA A  15
LEU A  16
 None
None
ADN  A1301 (-3.3A)
ADN  A1301 (-3.6A)
None
 1.10A 4rrxA-2c49A:
undetectable		 4rrxA-2c49A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dst HYPOTHETICAL PROTEIN
TTHA1544

(Thermus
thermophilus) 		no annotation 5 LEU A  26
LEU A   9
VAL A  70
GLY A  72
ALA A  71
 None
 0.97A 4rrxA-2dstA:
undetectable		 4rrxA-2dstA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
 None
 1.05A 4rrxA-2elcA:
undetectable		 4rrxA-2elcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
 None
 0.94A 4rrxA-2elcA:
undetectable		 4rrxA-2elcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
 None
 0.87A 4rrxA-2elcA:
undetectable		 4rrxA-2elcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fef HYPOTHETICAL PROTEIN
PA2201

(Pseudomonas
aeruginosa) 		PF08929
(DUF1911) 		5 LEU A 263
LEU A 153
GLY A 185
ALA A 186
LEU A 191
 None
 1.08A 4rrxA-2fefA:
undetectable		 4rrxA-2fefA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 TYR A 122
LEU A 126
TYR A 189
GLY A  54
SER A  58
 None
 1.04A 4rrxA-2gk9A:
undetectable		 4rrxA-2gk9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		5 VAL A  70
LEU A  71
GLY A 142
ALA A 143
LEU A 110
 None
 0.99A 4rrxA-2i34A:
undetectable		 4rrxA-2i34A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		5 LEU A 227
LEU A 218
GLY A 201
SER A 205
LEU A 206
 LEU  A 227 ( 0.6A)
LEU  A 218 ( 0.6A)
GLY  A 201 ( 0.0A)
SER  A 205 ( 0.0A)
LEU  A 206 ( 0.6A)
 1.08A 4rrxA-2ogsA:
undetectable		 4rrxA-2ogsA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		5 LEU A  36
LEU A   5
VAL A  64
GLY A  66
ALA A  68
 None
 0.98A 4rrxA-2or0A:
undetectable		 4rrxA-2or0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 679
TYR A 753
LEU A 909
ALA A 820
LEU A 862
 None
 1.01A 4rrxA-2pffA:
undetectable		 4rrxA-2pffA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 1.01A 4rrxA-2pplA:
undetectable		 4rrxA-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r48 PHOSPHOTRANSFERASE
SYSTEM (PTS)
MANNOSE-SPECIFIC
ENZYME IIBCA
COMPONENT

(Bacillus
subtilis) 		PF02302
(PTS_IIB) 		5 VAL A  67
VAL A  82
GLY A  81
ALA A  62
SER A  79
 None
 1.06A 4rrxA-2r48A:
undetectable		 4rrxA-2r48A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 5 LEU A 158
VAL A 174
ALA A 178
SER A 180
LEU A 181
 None
 0.91A 4rrxA-2xecA:
undetectable		 4rrxA-2xecA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 VAL A 313
LEU A 415
VAL A 267
GLY A 269
ALA A 268
 HEM  A1434 ( 4.9A)
None
None
HEM  A1434 (-3.3A)
HEM  A1434 (-3.5A)
 0.97A 4rrxA-2xn8A:
undetectable		 4rrxA-2xn8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		5 VAL D 611
LEU D 653
GLY D 603
ALA D 604
LEU D 593
 None
 1.09A 4rrxA-2yibD:
undetectable		 4rrxA-2yibD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhn THIJ/PFPI DOMAIN
PROTEIN

(Shewanella
loihica) 		PF01965
(DJ-1_PfpI) 		5 VAL A  64
LEU A  66
LEU A 139
VAL A 158
LEU A 165
 None
 1.11A 4rrxA-3bhnA:
undetectable		 4rrxA-3bhnA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		5 LEU A 355
VAL A 480
GLY A 482
SER A 486
LEU A 487
 None
 1.08A 4rrxA-3edyA:
undetectable		 4rrxA-3edyA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 LEU A 191
TRP A 196
VAL A 189
GLY A 187
ALA A 186
 None
 1.08A 4rrxA-3fz0A:
undetectable		 4rrxA-3fz0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5p NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		PF03177
(Nucleoporin_C) 		5 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.02A 4rrxA-3i5pA:
undetectable		 4rrxA-3i5pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 LEU A 208
LEU A 126
GLY A 106
ALA A 105
LEU A 194
 None
 1.01A 4rrxA-3l2zA:
undetectable		 4rrxA-3l2zA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 189
LEU A 142
VAL A 162
ALA A 163
LEU A  44
 None
 1.01A 4rrxA-3l7zA:
undetectable		 4rrxA-3l7zA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 LEU A  54
VAL A 139
GLY A 141
ALA A 143
SER A 145
 None
 0.94A 4rrxA-3lg5A:
0.6		 4rrxA-3lg5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 497
LEU A  42
VAL A  28
GLY A  25
ALA A  24
 None
None
None
None
FDA  A 547 (-3.8A)
 1.11A 4rrxA-3ljpA:
undetectable		 4rrxA-3ljpA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1

(Bos taurus) 		PF00481
(PP2C) 		5 LEU A  88
LEU A 141
ALA A  93
SER A  95
LEU A  96
 None
 1.02A 4rrxA-3mq3A:
undetectable		 4rrxA-3mq3A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		5 LEU A  62
VAL A 121
GLY A 125
ALA A 124
SER A 127
 None
None
None
EDO  A 235 (-4.3A)
None
 1.09A 4rrxA-3mvuA:
0.5		 4rrxA-3mvuA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE

(Burkholderia
lata) 		PF13378
(MR_MLE_C) 		5 VAL A 152
LEU A 156
LEU A  88
TYR A  84
ALA A 138
 None
 1.02A 4rrxA-3nxlA:
undetectable		 4rrxA-3nxlA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4y CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Plasmodium
vivax) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 LEU A 113
LEU A  64
GLY A  80
SER A  84
LEU A  86
 None
 1.02A 4rrxA-3o4yA:
undetectable		 4rrxA-3o4yA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg8 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		6 VAL A 268
LEU A 329
VAL A 290
ALA A 286
SER A 284
LEU A 283
 None
 1.38A 4rrxA-3pg8A:
undetectable		 4rrxA-3pg8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 TYR A 212
VAL A 186
LEU A 214
GLY A 103
ALA A 135
 None
 1.05A 4rrxA-3pwzA:
undetectable		 4rrxA-3pwzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis) 		PF00150
(Cellulase) 		5 VAL A  74
LEU A  79
VAL A 126
ALA A  93
LEU A  67
 None
 1.06A 4rrxA-3pzuA:
undetectable		 4rrxA-3pzuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 288
LEU A  18
GLY A  85
ALA A  84
SER A  81
 None
 0.91A 4rrxA-3rr1A:
undetectable		 4rrxA-3rr1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t0p DNA POLYMERASE III,
BETA SUBUNIT

([Eubacterium]
rectale) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 TYR A 117
LEU A  34
GLY A  65
ALA A  37
SER A  38
 None
 0.93A 4rrxA-3t0pA:
undetectable		 4rrxA-3t0pA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		5 VAL A  59
VAL A  79
GLY A  81
ALA A  83
LEU A  86
 None
 1.11A 4rrxA-3t33A:
undetectable		 4rrxA-3t33A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpa HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		5 VAL A  97
VAL A  44
GLY A  56
ALA A  58
LEU A  74
 None
 1.12A 4rrxA-3tpaA:
undetectable		 4rrxA-3tpaA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
 None
 1.07A 4rrxA-3uw2A:
undetectable		 4rrxA-3uw2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		6 TYR A  30
LEU A 367
VAL A 267
GLY A 368
ALA A 369
LEU A 393
 NAG  A 501 (-3.8A)
None
None
None
None
None
 1.33A 4rrxA-3wl1A:
undetectable		 4rrxA-3wl1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 5 LEU A  53
VAL A 489
GLY A 492
ALA A 493
LEU A 497
 None
 1.01A 4rrxA-4bb9A:
undetectable		 4rrxA-4bb9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxi ACCESSORY GENE
REGULATOR PROTEIN C

(Staphylococcus
aureus) 		PF14501
(HATPase_c_5) 		5 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.02A 4rrxA-4bxiA:
undetectable		 4rrxA-4bxiA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 VAL A  28
VAL A 112
GLY A 110
ALA A 109
LEU A  90
 None
 1.06A 4rrxA-4czpA:
undetectable		 4rrxA-4czpA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.10A 4rrxA-4dwqA:
undetectable		 4rrxA-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6c AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		PF07993
(NAD_binding_4) 		5 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.09A 4rrxA-4f6cA:
undetectable		 4rrxA-4f6cA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqn MALCAVERNIN

(Homo sapiens) 		PF16545
(CCM2_C) 		5 TYR A 342
LEU A 338
LEU A 299
TYR A 302
ALA A 319
 None
 1.09A 4rrxA-4fqnA:
undetectable		 4rrxA-4fqnA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h4c 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Escherichia
coli) 		PF02401
(LYTB) 		5 LEU A 231
VAL A 220
GLY A 267
ALA A 270
SER A 269
 None
None
None
None
10D  A 402 (-2.7A)
 1.11A 4rrxA-4h4cA:
undetectable		 4rrxA-4h4cA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 0.95A 4rrxA-4hkaA:
undetectable		 4rrxA-4hkaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		5 VAL A 149
LEU A 153
LEU A  86
TYR A  82
ALA A 135
 None
 1.00A 4rrxA-4hn8A:
undetectable		 4rrxA-4hn8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 VAL A  79
GLY A  81
ALA A  83
SER A  85
LEU A  86
 None
 0.77A 4rrxA-4j9uA:
0.7		 4rrxA-4j9uA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A  53
VAL A 489
GLY A 492
ALA A 493
LEU A 497
 None
 1.01A 4rrxA-4lc9A:
2.3		 4rrxA-4lc9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A 233
VAL A 265
GLY A 268
SER A 272
LEU A 273
 None
NAD  A 503 (-3.6A)
None
None
None
 0.87A 4rrxA-4lvcA:
undetectable		 4rrxA-4lvcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mc0 PUTATIVE
SESQUITERPENE
CYCLASE

(Kitasatospora
setae) 		no annotation 5 LEU A 279
LEU A 192
VAL A 293
ALA A 296
LEU A 209
 None
 1.12A 4rrxA-4mc0A:
undetectable		 4rrxA-4mc0A:
18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 TYR A 349
VAL A 350
LEU A 353
TYR A 356
LEU A 385
TYR A 386
TRP A 388
VAL A 524
GLY A 527
ALA A 528
LEU A 532
 None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
None
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
 0.58A 4rrxA-4ph9A:
63.2		 4rrxA-4ph9A:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 TYR A 349
VAL A 350
LEU A 353
TYR A 356
TYR A 386
TRP A 388
VAL A 524
ALA A 528
SER A 531
LEU A 532
 None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 (-4.8A)
None
IBP  A 601 ( 4.0A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.72A 4rrxA-4ph9A:
63.2		 4rrxA-4ph9A:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw8 TRYPTOPHAN
2,3-DIOXYGENASE

(Homo sapiens) 		PF03301
(Trp_dioxygenase) 		5 VAL A 205
LEU A 215
GLY A 291
ALA A 292
LEU A 311
 None
 0.91A 4rrxA-4pw8A:
undetectable		 4rrxA-4pw8A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0c VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 VAL A 313
GLY A 331
ALA A 334
SER A 333
LEU A 337
 None
 1.09A 4rrxA-4q0cA:
undetectable		 4rrxA-4q0cA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 LEU A 871
TYR A 874
VAL A 283
ALA A 301
LEU A 302
 None
 1.01A 4rrxA-4r7zA:
undetectable		 4rrxA-4r7zA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2

(Saccharomyces
cerevisiae) 		PF00909
(Ammonium_transp) 		5 LEU A 120
TYR A 128
GLY A 251
ALA A 250
SER A 249
 None
 1.12A 4rrxA-5aexA:
undetectable		 4rrxA-5aexA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		5 LEU A 447
VAL A 434
GLY A 437
ALA A 438
SER A 441
 None
 0.97A 4rrxA-5b1qA:
1.4		 4rrxA-5b1qA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A 240
LEU A 234
GLY A 253
ALA A 252
SER A 255
 None
 1.04A 4rrxA-5bz4A:
undetectable		 4rrxA-5bz4A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		5 LEU A  77
VAL A 103
GLY A 101
ALA A 102
SER A  98
 None
 0.98A 4rrxA-5cbkA:
undetectable		 4rrxA-5cbkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 VAL A 162
TYR A  46
GLY A 417
ALA A 420
LEU A 423
 None
 1.11A 4rrxA-5cqfA:
undetectable		 4rrxA-5cqfA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 LEU A  43
TYR A 109
GLY A  89
ALA A  88
LEU A 293
 None
 1.00A 4rrxA-5e3iA:
undetectable		 4rrxA-5e3iA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evl BETA-LACTAMASE

(Chromobacterium
violaceum) 		PF00144
(Beta-lactamase) 		5 TYR A 235
LEU A 183
GLY A  76
ALA A 251
SER A 255
 None
 1.04A 4rrxA-5evlA:
undetectable		 4rrxA-5evlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgl NICR

(Pseudomonas
putida) 		PF00440
(TetR_N) 		5 VAL A 111
LEU A 229
VAL A 177
GLY A 180
ALA A 181
 None
 1.01A 4rrxA-5fglA:
undetectable		 4rrxA-5fglA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g1d SYNTENIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 LEU A 131
VAL A 143
GLY A 128
ALA A 149
LEU A 119
 None
 1.11A 4rrxA-5g1dA:
undetectable		 4rrxA-5g1dA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggy IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		5 VAL A  67
LEU A 113
VAL A  96
GLY A  76
ALA A  77
 None
 1.09A 4rrxA-5ggyA:
undetectable		 4rrxA-5ggyA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 TYR A 348
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
VAL A 523
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.6A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.48A 4rrxA-5ikrA:
61.8		 4rrxA-5ikrA:
87.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		5 LEU A 512
VAL A 371
ALA A 336
SER A 334
LEU A 327
 None
 1.10A 4rrxA-5infA:
undetectable		 4rrxA-5infA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 VAL A 205
LEU A 244
VAL A 120
GLY A 122
LEU A 128
 None
 0.92A 4rrxA-5jfmA:
undetectable		 4rrxA-5jfmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct) 		PF04587
(ADP_PFK_GK) 		5 LEU A 304
TYR A 301
GLY A 320
ALA A 321
LEU A 325
 None
 1.10A 4rrxA-5kkgA:
undetectable		 4rrxA-5kkgA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		5 LEU M  14
VAL M  25
ALA M  29
SER M  31
LEU M  32
 None
 1.06A 4rrxA-5lc5M:
undetectable		 4rrxA-5lc5M:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.00A 4rrxA-5nugA:
undetectable		 4rrxA-5nugA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 LEU A 315
TYR A 312
GLY A 331
ALA A 332
LEU A 336
 None
 1.05A 4rrxA-5od2A:
undetectable		 4rrxA-5od2A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tii 3-OXOACYL-ACP
REDUCTASE

(uncultured
bacterium) 		PF13561
(adh_short_C2) 		5 VAL A  92
VAL A 225
GLY A 227
ALA A 226
LEU A  29
 None
 1.10A 4rrxA-5tiiA:
undetectable		 4rrxA-5tiiA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 TYR A 110
GLY A 320
ALA A 184
SER A 188
LEU A 189
 None
 0.86A 4rrxA-5tnxA:
undetectable		 4rrxA-5tnxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 TYR A 292
LEU A  32
GLY A  16
ALA A  15
SER A  13
 None
None
None
PO4  A 401 (-3.5A)
PO4  A 401 (-3.5A)
 1.11A 4rrxA-5tulA:
undetectable		 4rrxA-5tulA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veb CADHERIN-6

(Homo sapiens) 		PF00028
(Cadherin) 		5 VAL X 568
LEU X 527
LEU X 550
GLY X 548
ALA X 547
 None
 1.10A 4rrxA-5vebX:
undetectable		 4rrxA-5vebX:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vym BETA-GALACTOSIDASE
BGAB

(Bifidobacterium
adolescentis) 		PF08532
(Glyco_hydro_42M) 		5 LEU A 119
TYR A 107
GLY A 109
ALA A 110
LEU A  69
 None
 0.87A 4rrxA-5vymA:
undetectable		 4rrxA-5vymA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 VAL A 273
LEU A 192
GLY A 227
ALA A 229
LEU A 232
 None
 1.11A 4rrxA-5w4bA:
undetectable		 4rrxA-5w4bA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 VAL A 308
LEU A 278
GLY A 284
ALA A 283
LEU A 335
 None
 0.94A 4rrxA-5wy3A:
undetectable		 4rrxA-5wy3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xao UNCHARACTERIZED
PROTEIN

(Parastagonospora
nodorum) 		PF01266
(DAO) 		5 TYR A 170
VAL A 167
LEU A 171
GLY A 382
LEU A 378
 None
 1.11A 4rrxA-5xaoA:
undetectable		 4rrxA-5xaoA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 5 LEU A 564
VAL A 610
GLY A 612
ALA A 613
LEU A 616
 None
 1.10A 4rrxA-5yemA:
undetectable		 4rrxA-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckg D-GLYCERATE 3-KINASE

(Cryptococcus
neoformans) 		no annotation 5 LEU A  68
LEU A  73
GLY A  98
ALA A  97
LEU A 219
 None
 1.06A 4rrxA-6ckgA:
undetectable		 4rrxA-6ckgA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d79 SULFATE TRANSPORTER
CYSZ

(Pseudomonas
fragi) 		no annotation 5 VAL A  28
LEU A 103
LEU A 235
GLY A  15
LEU A  20
 None
 0.97A 4rrxA-6d79A:
undetectable		 4rrxA-6d79A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 0.98A 4rrxA-6en4C:
undetectable		 4rrxA-6en4C:
10.97