SIMILAR PATTERNS OF AMINO ACIDS FOR 4RP8_C_ASCC501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 SER A  40
TYR A  38
ASP A 131
 None
 0.75A 4rp8C-1ct9A:
0.0		 4rp8C-1ct9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		3 SER A 299
TYR A 320
ASP A 292
 None
None
PLP  A 342 ( 4.5A)
 0.80A 4rp8C-1f2dA:
0.0		 4rp8C-1f2dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		3 SER A 218
TYR A 147
ASP A  22
 None
None
ZN  A 401 ( 2.2A)
 0.70A 4rp8C-1ituA:
0.0		 4rp8C-1ituA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 SER A 172
TYR A 176
ASP A  61
 NGA  A 870 (-2.6A)
None
NGA  A 870 (-2.9A)
 0.89A 4rp8C-1ktcA:
0.0		 4rp8C-1ktcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		3 SER B 247
TYR B 249
ASP B 243
 None
None
BPY  B 401 (-3.9A)
 0.88A 4rp8C-1kwcB:
0.0		 4rp8C-1kwcB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		3 SER A 248
TYR A 250
ASP A 244
 None
P6G  A 600 ( 3.7A)
BP6  A 300 ( 4.4A)
 0.83A 4rp8C-1lkdA:
0.0		 4rp8C-1lkdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0z SENSOR KINASE CITA

(Klebsiella
pneumoniae) 		PF17203
(sCache_3_2) 		3 SER A 105
TYR A  56
ASP A  83
 None
FLC  A1632 (-3.8A)
OMO  A1631 (-3.9A)
 0.83A 4rp8C-1p0zA:
0.0		 4rp8C-1p0zA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		3 SER A 187
TYR A 191
ASP A  88
 None
None
ZN  A 270 (-2.4A)
 0.79A 4rp8C-1smlA:
0.0		 4rp8C-1smlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		3 SER A 201
TYR A 128
ASP A 257
 None
 0.74A 4rp8C-1sznA:
0.0		 4rp8C-1sznA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pseudomonas sp.
ACP) 		PF00291
(PALP) 		3 SER A 298
TYR A 319
ASP A 291
 None
None
PLP  A 401 ( 4.9A)
 0.77A 4rp8C-1tzmA:
undetectable		 4rp8C-1tzmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 SER A 160
TYR A 126
ASP A 216
 None
None
GLA  A1501 ( 4.4A)
 0.75A 4rp8C-1uasA:
undetectable		 4rp8C-1uasA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		3 SER A  60
TYR A  32
ASP A  80
 GLU  A1313 (-2.6A)
GLU  A1313 (-3.7A)
None
 0.73A 4rp8C-1us4A:
undetectable		 4rp8C-1us4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I

(Thermoproteus
tenax) 		PF01791
(DeoC) 		3 SER A  92
TYR A 114
ASP A  24
 None
None
FBP  A 270 (-2.8A)
 0.85A 4rp8C-1w8sA:
undetectable		 4rp8C-1w8sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		3 SER A 104
TYR A 106
ASP A 292
 None
 0.73A 4rp8C-1wyeA:
2.1		 4rp8C-1wyeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 SER A 967
TYR A 930
ASP A 801
 None
 0.86A 4rp8C-1xc6A:
undetectable		 4rp8C-1xc6A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		3 SER A 229
TYR A 196
ASP A  40
 None
 0.66A 4rp8C-1xvxA:
undetectable		 4rp8C-1xvxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		3 SER A 226
TYR A 193
ASP A  37
 None
 0.68A 4rp8C-1xvyA:
undetectable		 4rp8C-1xvyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 SER A 130
TYR A 132
ASP A 167
 None
 0.90A 4rp8C-1y9gA:
undetectable		 4rp8C-1y9gA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 SER A 251
TYR A 263
ASP A  90
 None
 0.86A 4rp8C-2b2cA:
undetectable		 4rp8C-2b2cA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl8 DECTIN-1

(Mus musculus) 		PF00059
(Lectin_C) 		3 SER A 129
TYR A 131
ASP A 158
 CA  A1245 ( 4.8A)
None
CA  A1245 (-3.3A)
 0.81A 4rp8C-2cl8A:
undetectable		 4rp8C-2cl8A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		3 SER A 467
TYR A 471
ASP A 442
 None
 0.88A 4rp8C-2e0pA:
undetectable		 4rp8C-2e0pA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		3 SER A  78
TYR A  76
ASP A  82
 None
 0.89A 4rp8C-2ewyA:
undetectable		 4rp8C-2ewyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		3 SER A 305
TYR A 285
ASP A  16
 SAH  A 328 (-2.7A)
None
None
 0.90A 4rp8C-2i9kA:
undetectable		 4rp8C-2i9kA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 SER A 512
TYR A 507
ASP A 598
 None
 0.85A 4rp8C-2iujA:
undetectable		 4rp8C-2iujA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbi HEP200 PROTEIN

(Cylindrotheca
fusiformis) 		no annotation 3 SER A 125
TYR A 117
ASP A 156
 None
 0.89A 4rp8C-2nbiA:
undetectable		 4rp8C-2nbiA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ULTRASPIRACLE (USP,
NR2B4)
ECDYSONE RECEPTOR
(ECR, NRH1)

(Tribolium
castaneum;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		3 SER E 509
TYR A 343
ASP A 325
 None
 0.82A 4rp8C-2nxxE:
undetectable		 4rp8C-2nxxE:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p90 HYPOTHETICAL PROTEIN
CGL1923

(Corynebacterium
glutamicum) 		PF09754
(PAC2) 		3 SER A 195
TYR A 197
ASP A 161
 None
 0.88A 4rp8C-2p90A:
undetectable		 4rp8C-2p90A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		3 SER B 256
TYR B 266
ASP B 260
 None
 0.65A 4rp8C-2pbiB:
undetectable		 4rp8C-2pbiB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		3 SER A 173
TYR A 186
ASP A 134
 None
 0.82A 4rp8C-2pxxA:
undetectable		 4rp8C-2pxxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN

(Prochlorococcus
phage P-SSM2) 		PF05996
(Fe_bilin_red) 		3 SER A  84
TYR A 211
ASP A  58
 None
GOL  A1235 ( 4.7A)
None
 0.77A 4rp8C-2vclA:
undetectable		 4rp8C-2vclA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION

(Nostoc
punctiforme) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 SER A 321
TYR A 260
ASP A 122
 None
 0.90A 4rp8C-2wc7A:
undetectable		 4rp8C-2wc7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 SER A  25
TYR A  23
ASP A 125
 None
 0.86A 4rp8C-2x4dA:
undetectable		 4rp8C-2x4dA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		3 SER A 556
TYR A 552
ASP A 609
 None
 0.84A 4rp8C-2x6kA:
undetectable		 4rp8C-2x6kA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		3 SER A  93
TYR A  90
ASP A 158
 None
 0.83A 4rp8C-2yg6A:
undetectable		 4rp8C-2yg6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6b BASEPLATE STRUCTURAL
PROTEIN GP27

(Escherichia
virus T4) 		PF09096
(Phage-tail_2)
PF09097
(Phage-tail_1) 		3 SER D 131
TYR D 169
ASP D 159
 None
 0.81A 4rp8C-2z6bD:
undetectable		 4rp8C-2z6bD:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		3 SER A 164
TYR A 125
ASP A 240
 None
 0.87A 4rp8C-3a5vA:
undetectable		 4rp8C-3a5vA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		3 SER A 187
TYR A  72
ASP A  79
 None
 0.90A 4rp8C-3ag6A:
2.2		 4rp8C-3ag6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agb RED CHLOROPHYLL
CATABOLITE
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06405
(RCC_reductase) 		3 SER A 209
TYR A 207
ASP A 291
 None
 0.85A 4rp8C-3agbA:
undetectable		 4rp8C-3agbA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		3 SER A  76
TYR A  78
ASP A  22
 None
 0.81A 4rp8C-3cnyA:
undetectable		 4rp8C-3cnyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		3 SER A 303
TYR A 301
ASP A 346
 None
 0.73A 4rp8C-3drkA:
undetectable		 4rp8C-3drkA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fm0 PROTEIN CIAO1

(Homo sapiens) 		PF00400
(WD40) 		3 SER A 167
TYR A 177
ASP A 171
 None
 0.64A 4rp8C-3fm0A:
undetectable		 4rp8C-3fm0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 SER A 283
TYR A  68
ASP A  41
 None
 0.84A 4rp8C-3gfvA:
0.8		 4rp8C-3gfvA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		3 SER A 186
TYR A  71
ASP A  78
 ATP  A 300 ( 4.9A)
None
None
 0.89A 4rp8C-3innA:
undetectable		 4rp8C-3innA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j82 C-TYPE LECTIN DOMAIN
FAMILY 9 MEMBER A

(Mus musculus) 		PF00059
(Lectin_C) 		3 SER A 147
TYR A 149
ASP A 176
 CA  A 301 ( 4.1A)
None
CA  A 301 ( 4.1A)
 0.68A 4rp8C-3j82A:
undetectable		 4rp8C-3j82A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhn LIPOPROTEIN

(Shewanella
oneidensis) 		PF04170
(NlpE) 		3 SER A  85
TYR A  87
ASP A 114
 None
 0.75A 4rp8C-3lhnA:
undetectable		 4rp8C-3lhnA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		3 SER A 291
TYR A 301
ASP A 295
 None
 0.85A 4rp8C-3ow8A:
undetectable		 4rp8C-3ow8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr4 DNA POLYMERASE IV

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 SER A 145
TYR A 118
ASP A 231
 None
 0.84A 4rp8C-3pr4A:
2.0		 4rp8C-3pr4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE

(Yersinia pestis) 		PF02569
(Pantoate_ligase) 		3 SER A 188
TYR A  71
ASP A  78
 AMP  A 501 ( 4.9A)
None
None
 0.84A 4rp8C-3q10A:
undetectable		 4rp8C-3q10A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor) 		PF01244
(Peptidase_M19) 		3 SER A 211
TYR A 145
ASP A  22
 None
None
ZN  A 402 ( 2.2A)
 0.77A 4rp8C-3s2jA:
undetectable		 4rp8C-3s2jA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF02569
(Pantoate_ligase) 		3 SER A 183
TYR A  67
ASP A  74
 None
 0.80A 4rp8C-3uk2A:
undetectable		 4rp8C-3uk2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukn NOVEL PROTEIN
SIMILAR TO
VERTEBRATE POTASSIUM
VOLTAGE-GATED
CHANNEL, SUBFAMILY H
(EAG-RELATED) FAMILY

(Danio rerio) 		PF00027
(cNMP_binding) 		3 SER A 631
TYR A 723
ASP A 601
 None
 0.85A 4rp8C-3uknA:
undetectable		 4rp8C-3uknA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uy4 PANTOTHENATE
SYNTHETASE

(Campylobacter
jejuni) 		PF02569
(Pantoate_ligase) 		3 SER A 185
TYR A  70
ASP A  77
 AMP  A 301 ( 4.9A)
None
None
 0.87A 4rp8C-3uy4A:
2.1		 4rp8C-3uy4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6o LEPTIN RECEPTOR
MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation
PF07654
(C1-set)
PF07686
(V-set) 		3 SER A 507
TYR A 509
ASP C  34
 None
None
ACT  C 301 (-2.8A)
 0.75A 4rp8C-3v6oA:
undetectable		 4rp8C-3v6oA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		3 SER A 479
TYR A 420
ASP A 448
 None
 0.89A 4rp8C-3vilA:
undetectable		 4rp8C-3vilA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		3 SER A 177
TYR A  66
ASP A 127
 None
 0.89A 4rp8C-3zdbA:
undetectable		 4rp8C-3zdbA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C

(Escherichia
coli) 		PF01464
(SLT)
PF11873
(DUF3393) 		3 SER A  76
TYR A  65
ASP A 123
 None
 0.89A 4rp8C-4c5fA:
undetectable		 4rp8C-4c5fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		3 SER A  41
TYR A  96
ASP A  68
 None
 0.81A 4rp8C-4h1xA:
undetectable		 4rp8C-4h1xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		3 SER L  73
TYR L 251
ASP L 122
 None
 0.81A 4rp8C-4heaL:
2.7		 4rp8C-4heaL:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		3 SER A 176
TYR A  72
ASP A 203
 None
 0.78A 4rp8C-4hwvA:
undetectable		 4rp8C-4hwvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 SER A 961
TYR A 924
ASP A 798
 None
 0.85A 4rp8C-4iugA:
undetectable		 4rp8C-4iugA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		3 SER A 308
TYR A  91
ASP A  64
 None
 0.86A 4rp8C-4jccA:
undetectable		 4rp8C-4jccA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		3 SER A 492
TYR A 502
ASP A 496
 None
 0.67A 4rp8C-4lg8A:
undetectable		 4rp8C-4lg8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		3 SER A 304
TYR A 288
ASP A 403
 None
 0.90A 4rp8C-4mguA:
undetectable		 4rp8C-4mguA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN

(Vibrio cholerae) 		PF00165
(HTH_AraC) 		3 SER A 175
TYR A  26
ASP A  88
 None
 0.84A 4rp8C-4mloA:
undetectable		 4rp8C-4mloA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4moz FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Slackia
heliotrinireducens) 		PF01791
(DeoC) 		3 SER A 119
TYR A 146
ASP A  43
 None
 0.88A 4rp8C-4mozA:
undetectable		 4rp8C-4mozA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 SER A 600
TYR A 262
ASP A  23
 None
 0.85A 4rp8C-4na3A:
undetectable		 4rp8C-4na3A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 SER A 519
TYR A 529
ASP A 523
 None
 0.82A 4rp8C-4nsxA:
undetectable		 4rp8C-4nsxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		3 SER A  18
TYR A 319
ASP A 409
 None
 0.83A 4rp8C-4q76A:
0.8		 4rp8C-4q76A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdq BESTROPHIN-1

(Gallus gallus) 		PF01062
(Bestrophin) 		3 SER A  47
TYR A  43
ASP A 270
 None
 0.71A 4rp8C-4rdqA:
2.8		 4rp8C-4rdqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 SER A2666
TYR A2618
ASP A3343
 None
 0.81A 4rp8C-4rh7A:
undetectable		 4rp8C-4rh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		3 SER A 324
TYR A 108
ASP A 263
 NA  A 701 ( 2.4A)
TRP  A 601 (-4.8A)
NA  A 702 (-2.8A)
 0.90A 4rp8C-4us4A:
0.5		 4rp8C-4us4A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 3 SER A 205
TYR A 407
ASP A 243
 None
 0.83A 4rp8C-4xhpA:
2.2		 4rp8C-4xhpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuu PHOSPHATIDYLINOSITID
E PHOSPHATASE SAC2

(Homo sapiens) 		PF12456
(hSac2) 		3 SER A  54
TYR A  59
ASP A  23
 None
 0.81A 4rp8C-4xuuA:
undetectable		 4rp8C-4xuuA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfq L,D-TRANSPEPTIDASE 5

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		3 SER A 271
TYR A 290
ASP A 285
 None
 0.81A 4rp8C-4zfqA:
undetectable		 4rp8C-4zfqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		3 SER A 167
TYR A 291
ASP A 394
 GLC  A 501 ( 4.6A)
GLC  A 502 ( 4.2A)
GLC  A 501 ( 3.0A)
 0.89A 4rp8C-4zzeA:
undetectable		 4rp8C-4zzeA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		3 SER A 297
TYR A  84
ASP A  57
 None
 0.88A 4rp8C-5advA:
undetectable		 4rp8C-5advA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 3 SER A 240
TYR A 193
ASP A 312
 None
None
BGC  A 701 ( 4.0A)
 0.65A 4rp8C-5awpA:
undetectable		 4rp8C-5awpA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 SER A 540
TYR A 621
ASP A 555
 None
 0.88A 4rp8C-5dmyA:
undetectable		 4rp8C-5dmyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		3 SER A 338
TYR A 352
ASP A 226
 ZN  A 402 ( 4.8A)
None
ZN  A 402 ( 2.8A)
 0.80A 4rp8C-5gneA:
undetectable		 4rp8C-5gneA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hg0 PANTOTHENATE
SYNTHETASE

(Francisella
tularensis) 		PF02569
(Pantoate_ligase) 		3 SER A 186
TYR A  70
ASP A  77
 SAM  A 301 ( 4.6A)
None
None
 0.86A 4rp8C-5hg0A:
undetectable		 4rp8C-5hg0A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		3 SER A 223
TYR A 156
ASP A  25
 None
None
FE  A 401 (-2.0A)
 0.70A 4rp8C-5lx0A:
undetectable		 4rp8C-5lx0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		3 SER A 308
TYR A 298
ASP A 161
 None
 0.86A 4rp8C-5mchA:
undetectable		 4rp8C-5mchA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP1
CAPSID SUBUNIT VP3

(Parechovirus A;
Parechovirus A) 		no annotation
no annotation 		3 SER B 144
TYR B 146
ASP A  39
 None
 0.62A 4rp8C-5mjvB:
undetectable		 4rp8C-5mjvB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Chlamydomonas
reinhardtii) 		PF00400
(WD40) 		3 SER A 322
TYR A 332
ASP A 326
 None
 0.82A 4rp8C-5mzhA:
undetectable		 4rp8C-5mzhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 SER A 341
TYR A 316
ASP A 131
 None
 0.80A 4rp8C-5ngkA:
undetectable		 4rp8C-5ngkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 SER A 631
TYR A 629
ASP A 604
 None
 0.77A 4rp8C-5o1pA:
undetectable		 4rp8C-5o1pA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		3 SER A 287
TYR A 292
ASP A 281
 None
 0.72A 4rp8C-5t6oA:
undetectable		 4rp8C-5t6oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpi PUTATIVE
TRANSCRIPTIONAL
REGULATOR (LYSR
FAMILY)

(Klebsiella
pneumoniae) 		PF03466
(LysR_substrate) 		3 SER A  98
TYR A 218
ASP A 145
 CL  A 301 (-2.9A)
CL  A 301 (-4.9A)
None
 0.69A 4rp8C-5tpiA:
undetectable		 4rp8C-5tpiA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 SER A 271
TYR A 275
ASP A 250
 None
 0.83A 4rp8C-5tu0A:
1.2		 4rp8C-5tu0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		3 SER C 173
TYR C 177
ASP C 525
 None
 0.90A 4rp8C-5tw1C:
1.4		 4rp8C-5tw1C:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		3 SER A  34
TYR A 167
ASP A  27
 None
 0.65A 4rp8C-5ucdA:
undetectable		 4rp8C-5ucdA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		3 SER E 294
TYR E 250
ASP E 297
 None
 0.89A 4rp8C-5v8fE:
undetectable		 4rp8C-5v8fE:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 3 SER A 149
TYR A 143
ASP A 132
 PO4  A1202 (-2.6A)
PO4  A1202 (-4.2A)
PO4  A1205 (-4.7A)
 0.70A 4rp8C-5wivA:
undetectable		 4rp8C-5wivA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 3 SER A 610
TYR A 561
ASP A 618
 None
 0.86A 4rp8C-5xm3A:
undetectable		 4rp8C-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 3 SER A 638
TYR A 703
ASP A 685
 None
 0.87A 4rp8C-6aunA:
undetectable		 4rp8C-6aunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsu XYLOGLUCAN
6-XYLOSYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 3 SER A 157
TYR A 191
ASP A 168
 None
 0.82A 4rp8C-6bsuA:
undetectable		 4rp8C-6bsuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2

(Eptatretus
burgeri;
Danio rerio;
Petromyzon
marinus) 		no annotation
no annotation 		3 SER C  58
TYR A 105
ASP C  34
 None
 0.88A 4rp8C-6bxaC:
undetectable		 4rp8C-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dip NOCTURNIN

(Homo sapiens) 		no annotation 3 SER A 412
TYR A 410
ASP A 377
 None
 0.87A 4rp8C-6dipA:
undetectable		 4rp8C-6dipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 3 SER A 632
TYR A 630
ASP A 668
 None
 0.83A 4rp8C-6f2tA:
undetectable		 4rp8C-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4c ALPHA-GALACTOSIDASE

(Nicotiana
benthamiana) 		no annotation 3 SER B 211
TYR B 177
ASP B 267
 None
 0.67A 4rp8C-6f4cB:
undetectable		 4rp8C-6f4cB:
undetectable