SIMILAR PATTERNS OF AMINO ACIDS FOR 4RP8_C_ASCC501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		5 LEU A 150
ILE A 275
ILE A   8
ILE A  28
PHE A  25
 None
 1.23A 4rp8C-1a7jA:
0.0		 4rp8C-1a7jA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A 192
ILE A 225
ILE A 191
ILE A 294
PHE A 263
 None
 1.11A 4rp8C-1kywA:
0.0		 4rp8C-1kywA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 LEU A 343
THR A 215
ILE A 184
ALA A 202
PHE A 208
 None
 1.14A 4rp8C-1lnlA:
0.0		 4rp8C-1lnlA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvf IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION

(Camelus
dromedarius) 		PF07686
(V-set) 		5 ILE A  53
GLN A  72
ILE A  59
ALA A 107
ILE A  70
 None
 1.10A 4rp8C-1mvfA:
undetectable		 4rp8C-1mvfA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A 445
ILE A 438
ILE A 109
ILE A 464
MET A 473
 None
 1.07A 4rp8C-1obbA:
0.0		 4rp8C-1obbA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		5 LEU A  46
THR A 107
ILE A 123
ALA A  18
PHE A  20
 None
 1.17A 4rp8C-1pzsA:
0.0		 4rp8C-1pzsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		5 LEU A 257
THR A 282
ILE A 274
ALA A 312
ILE A 286
 None
 1.22A 4rp8C-1q6yA:
0.0		 4rp8C-1q6yA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 LEU A 282
ILE A 227
ILE A 322
ILE A 125
PHE A 252
 None
 1.13A 4rp8C-1qhoA:
0.0		 4rp8C-1qhoA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri6 PUTATIVE ISOMERASE
YBHE

(Escherichia
coli) 		PF10282
(Lactonase) 		5 LEU A 313
THR A 239
ILE A 255
ALA A 293
PHE A 282
 None
 1.25A 4rp8C-1ri6A:
undetectable		 4rp8C-1ri6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vio RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A

(Haemophilus
influenzae) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		5 LEU A 166
THR A 161
ILE A 178
GLN A 185
ILE A 152
 None
 1.03A 4rp8C-1vioA:
undetectable		 4rp8C-1vioA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG

(Clostridium
acetobutylicum) 		PF04321
(RmlD_sub_bind) 		5 ILE A 275
GLN A 279
ALA A 218
ILE A 227
PHE A 222
 None
 1.14A 4rp8C-1vl0A:
undetectable		 4rp8C-1vl0A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjl ANNEXIN A2

(Homo sapiens) 		PF00191
(Annexin) 		5 LEU A 174
ILE A 263
ALA A 255
PHE A 256
MET A 240
 None
 1.16A 4rp8C-1xjlA:
undetectable		 4rp8C-1xjlA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg) 		5 LEU A 108
ILE A   6
ILE A 105
ALA A  20
PHE A  16
 None
 1.06A 4rp8C-1zh4A:
undetectable		 4rp8C-1zh4A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Homo sapiens) 		PF16770
(RTT107_BRCT_5) 		5 LEU A1987
ILE A1947
ALA A1940
ILE A1931
PHE A1937
 None
 1.21A 4rp8C-2adoA:
undetectable		 4rp8C-2adoA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctm VIGILIN

(Homo sapiens) 		PF00013
(KH_1) 		5 LEU A  82
HIS A  78
ILE A  31
ALA A  38
ILE A  50
 None
 0.99A 4rp8C-2ctmA:
undetectable		 4rp8C-2ctmA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5u N-GLYCANASE 1

(Mus musculus) 		PF09409
(PUB) 		5 LEU A  48
ILE A 106
GLN A 102
ILE A  47
PHE A  85
 None
 1.12A 4rp8C-2d5uA:
undetectable		 4rp8C-2d5uA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 HIS A 149
ILE A 150
ALA A 108
ILE A  92
PHE A  88
 None
 1.12A 4rp8C-2dy3A:
undetectable		 4rp8C-2dy3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		6 LEU A 334
ILE A 167
GLN A 208
ILE A 330
ILE A 218
PHE A 209
 None
 1.40A 4rp8C-2e87A:
2.2		 4rp8C-2e87A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		5 LEU A 207
GLN A 186
GLN A 187
ALA A 195
MET A 166
 None
 1.10A 4rp8C-2f5xA:
undetectable		 4rp8C-2f5xA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		5 LEU A  42
THR A  74
ILE A  99
ALA A  87
ILE A  19
 None
 0.96A 4rp8C-2hcuA:
undetectable		 4rp8C-2hcuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		5 LEU A 519
THR A 454
ILE A 482
ILE A 490
ILE A 452
 None
 1.22A 4rp8C-2hroA:
undetectable		 4rp8C-2hroA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Saccharomyces
cerevisiae;
Aequorea
victoria) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		5 HIS A 330
ILE A 331
ALA A 268
ILE A 260
PHE A 266
 None
 1.13A 4rp8C-2jadA:
undetectable		 4rp8C-2jadA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q34 CURF

(Moorea
producens) 		PF00378
(ECH_1) 		5 LEU A 122
ILE A  45
ILE A 100
ILE A  30
PHE A  53
 None
 1.19A 4rp8C-2q34A:
undetectable		 4rp8C-2q34A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbg PUTATIVE
UNCHARACTERIZED
PROTEIN ST0493

(Sulfurisphaera
tokodaii) 		no annotation 5 LEU A  69
ILE A  38
ILE A  44
ILE A  53
PHE A  17
 None
 1.25A 4rp8C-2rbgA:
undetectable		 4rp8C-2rbgA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 LEU B 386
THR B 263
HIS B 388
GLN B 265
ILE B 279
 None
 1.14A 4rp8C-2uzxB:
undetectable		 4rp8C-2uzxB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1l HYPOTHETICAL PROTEIN

(Vibrio cholerae) 		PF10980
(DUF2787) 		5 LEU A  64
THR A   9
HIS A  18
ILE A  62
PHE A  17
 None
 1.14A 4rp8C-2v1lA:
undetectable		 4rp8C-2v1lA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 THR A 344
ILE A 396
GLN A  49
ILE A  11
PHE A 298
 None
 1.24A 4rp8C-2zktA:
undetectable		 4rp8C-2zktA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		6 LEU C 163
ILE C 176
ILE C 217
ALA C 134
ILE C 143
PHE C 139
 None
 1.41A 4rp8C-3aizC:
undetectable		 4rp8C-3aizC:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		5 LEU A 108
ILE A  98
ILE A 113
ALA A 234
ILE A 243
 None
 0.80A 4rp8C-3ax6A:
undetectable		 4rp8C-3ax6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		5 LEU A 126
THR A 158
ILE A 133
ILE A 171
ILE A 138
 None
None
GOL  A 209 ( 4.7A)
None
None
 1.20A 4rp8C-3bbhA:
undetectable		 4rp8C-3bbhA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 HIS A 155
HIS A 145
ILE A 116
ALA A 114
ILE A 153
 ZN  A 503 ( 3.3A)
ZN  A 503 ( 3.3A)
None
None
None
 1.25A 4rp8C-3dslA:
undetectable		 4rp8C-3dslA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 422
THR A 391
ILE A 316
ILE A 411
ALA A 407
 None
 1.24A 4rp8C-3eh7A:
undetectable		 4rp8C-3eh7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		5 LEU A 221
GLN A  92
ALA A  97
ILE A  85
PHE A 248
 None
 1.23A 4rp8C-3getA:
undetectable		 4rp8C-3getA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		5 LEU A 262
ILE A 314
ALA A 307
ILE A 242
PHE A 239
 None
 1.23A 4rp8C-3hjlA:
undetectable		 4rp8C-3hjlA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B  39
ILE B 394
ILE B  43
ILE B 116
PHE B 358
 None
 1.23A 4rp8C-3hkzB:
undetectable		 4rp8C-3hkzB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 LEU A 639
ILE A 619
ILE A 634
ILE A 691
PHE A 687
 None
 1.19A 4rp8C-3ibjA:
1.4		 4rp8C-3ibjA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5h PHOSPHORIBOSYL-AMINO
IMIDAZOLE
CARBOXYLASE

(Aspergillus
clavatus) 		PF01262
(AlaDh_PNT_C)
PF02222
(ATP-grasp) 		5 THR A 279
ILE A 193
GLN A 287
ILE A 300
ALA A 294
 None
 1.25A 4rp8C-3k5hA:
undetectable		 4rp8C-3k5hA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		5 LEU A 102
THR A 233
ALA A  79
ILE A 230
PHE A 229
 None
None
FAD  A 401 (-3.7A)
None
FAD  A 401 (-4.4A)
 1.16A 4rp8C-3kljA:
undetectable		 4rp8C-3kljA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF02815
(MIR) 		5 ILE A 150
GLN A 161
ILE A 105
ALA A 103
ILE A  37
 None
SO4  A   1 (-4.0A)
None
None
None
 1.24A 4rp8C-3malA:
undetectable		 4rp8C-3malA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 THR B 157
ILE B 250
ILE B 256
ALA B 208
ILE B 152
 None
 0.97A 4rp8C-3mcaB:
undetectable		 4rp8C-3mcaB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtx PROTEIN MD-1

(Gallus gallus) 		PF02221
(E1_DerP2_DerF2) 		5 LEU A 123
ILE A  63
ILE A 135
ALA A 137
ILE A  35
 None
None
PGT  A 300 (-4.7A)
PGT  A 300 ( 3.9A)
PGT  A 300 ( 4.6A)
 1.09A 4rp8C-3mtxA:
undetectable		 4rp8C-3mtxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohe HISTIDINE TRIAD
(HIT) PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF01230
(HIT) 		5 LEU A  57
GLN A  88
ILE A  46
ALA A  81
ILE A  43
 None
 1.20A 4rp8C-3oheA:
undetectable		 4rp8C-3oheA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		5 ILE A  47
GLN A  44
ILE A 141
ALA A 127
ILE A  40
 None
 1.10A 4rp8C-3tr7A:
undetectable		 4rp8C-3tr7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		5 LEU A 194
ILE A  21
HIS A 234
ILE A 193
ILE A 284
 HEC  A1001 ( 3.7A)
SO4  A 534 ( 3.9A)
HEC  A1002 (-3.1A)
HEC  A1002 (-4.1A)
None
 1.03A 4rp8C-3ttbA:
2.8		 4rp8C-3ttbA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		5 LEU A 133
ILE A 107
ILE A 169
ALA A 172
PHE A 173
 None
 1.18A 4rp8C-3ujpA:
1.4		 4rp8C-3ujpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usw FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 LEU A 271
ILE A 323
ALA A 316
ILE A 251
PHE A 248
 None
 1.18A 4rp8C-3uswA:
undetectable		 4rp8C-3uswA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usy FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 LEU A 271
ILE A 323
ALA A 316
ILE A 251
PHE A 248
 None
 1.17A 4rp8C-3usyA:
undetectable		 4rp8C-3usyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		5 LEU A 377
ILE A 267
ILE A 373
ALA A 189
PHE A 190
 None
 0.78A 4rp8C-3vs8A:
undetectable		 4rp8C-3vs8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 LEU A 170
GLN A 134
ILE A 119
ILE A  96
PHE A 132
 None
 1.00A 4rp8C-3wa1A:
undetectable		 4rp8C-3wa1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 ILE B1013
GLN B1115
ILE B1073
ALA B1003
PHE B1112
 None
 1.05A 4rp8C-3zefB:
undetectable		 4rp8C-3zefB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 ILE A 632
GLN A 583
ILE A 604
ALA A 607
PHE A 635
 None
 1.12A 4rp8C-3ziuA:
undetectable		 4rp8C-3ziuA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		5 LEU A 198
ILE A 290
ILE A 200
ALA A 351
ILE A 331
 None
 1.25A 4rp8C-4a1fA:
3.4		 4rp8C-4a1fA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF01058
(Oxidored_q6) 		5 LEU B 199
ILE B 254
GLN B 258
ALA B 134
ILE B 177
 None
SF4  B1275 ( 4.6A)
None
None
None
 1.21A 4rp8C-4ci0B:
undetectable		 4rp8C-4ci0B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		5 HIS A 186
ILE A 213
ILE A 241
ALA A 233
ILE A 487
 None
 1.09A 4rp8C-4ddqA:
1.9		 4rp8C-4ddqA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE

(Clostridioides
difficile) 		PF00155
(Aminotran_1_2) 		5 LEU A 351
ILE A 387
ILE A 367
ALA A 379
ILE A 307
 None
 1.06A 4rp8C-4dq6A:
undetectable		 4rp8C-4dq6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eay MANNONATE
DEHYDRATASE

(Escherichia
coli) 		PF03786
(UxuA) 		5 LEU A 197
THR A 111
ILE A 241
ILE A 177
PHE A 136
 None
 1.20A 4rp8C-4eayA:
undetectable		 4rp8C-4eayA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ese FMN-DEPENDENT
NADH-AZOREDUCTASE

(Yersinia pestis) 		PF02525
(Flavodoxin_2) 		5 LEU A   7
ILE A  48
ILE A  92
ILE A 112
PHE A 109
 None
 1.24A 4rp8C-4eseA:
undetectable		 4rp8C-4eseA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 ILE A 219
ILE A 189
ALA A 212
ILE A 202
PHE A 203
 None
 1.10A 4rp8C-4fdwA:
undetectable		 4rp8C-4fdwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 LEU B 261
ILE B 313
ALA B 306
ILE B 241
PHE B 238
 None
 1.18A 4rp8C-4fhrB:
undetectable		 4rp8C-4fhrB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi5 QUINONE REDUCTASE

(Klebsiella
pneumoniae) 		PF02525
(Flavodoxin_2) 		5 LEU A  88
ILE A   6
ALA A 147
ILE A 113
MET A 105
 None
 1.25A 4rp8C-4gi5A:
undetectable		 4rp8C-4gi5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 LEU A 332
ILE A 355
ALA A 382
ILE A 369
PHE A 383
 None
None
EDO  A 509 (-4.5A)
None
None
 1.15A 4rp8C-4h09A:
undetectable		 4rp8C-4h09A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 LEU A 639
ILE A 619
ILE A 634
ILE A 691
PHE A 687
 None
 1.05A 4rp8C-4htzA:
2.1		 4rp8C-4htzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		5 LEU A  55
ILE A  51
ALA A 205
ILE A 197
PHE A 240
 None
None
None
LLP  A 196 ( 4.0A)
None
 1.25A 4rp8C-4ixoA:
undetectable		 4rp8C-4ixoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 LEU B 386
THR B 263
HIS B 388
GLN B 265
ILE B 279
 None
 1.10A 4rp8C-4k3jB:
undetectable		 4rp8C-4k3jB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kny KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A 108
ILE A   6
ILE A 105
ALA A  20
PHE A  16
 None
 0.96A 4rp8C-4knyA:
undetectable		 4rp8C-4knyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET) 		5 LEU A 619
ILE A 721
ILE A 689
ALA A 692
PHE A 729
 None
 1.08A 4rp8C-4mi5A:
undetectable		 4rp8C-4mi5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oue PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		5 LEU A 459
ILE A 441
ILE A 390
ALA A 388
PHE A 379
 None
 1.23A 4rp8C-4oueA:
undetectable		 4rp8C-4oueA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 LEU A 401
ILE A 509
ILE A 406
ALA A 297
PHE A 294
 None
 1.19A 4rp8C-4pfwA:
undetectable		 4rp8C-4pfwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 LEU A 401
ILE A 507
ILE A 406
ALA A 297
PHE A 294
 None
 1.14A 4rp8C-4pfyA:
undetectable		 4rp8C-4pfyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 5 LEU B 298
ILE B 306
ILE B 254
ALA B 236
ILE B 232
 None
 1.14A 4rp8C-4pl2B:
undetectable		 4rp8C-4pl2B:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F

(Thermococcus
kodakarensis) 		PF03874
(RNA_pol_Rpb4) 		5 LEU F  66
ILE F 112
ILE F  73
ILE F  95
PHE F  96
 None
 1.19A 4rp8C-4qiwF:
undetectable		 4rp8C-4qiwF:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 5 LEU B 425
THR B 419
ILE B 432
ILE B 392
MET B 336
 None
None
FA5  B 701 (-4.1A)
None
FA5  B 701 (-4.2A)
 1.22A 4rp8C-4r0mB:
undetectable		 4rp8C-4r0mB:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		10 THR A  86
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ALA A 316
ILE A 358
PHE A 362
MET A 410
 ASC  A 501 (-3.3A)
ASC  A 501 (-4.1A)
None
ASC  A 501 (-2.5A)
ASC  A 501 (-4.1A)
ASC  A 501 (-4.0A)
ASC  A 501 ( 3.7A)
ASC  A 501 ( 4.9A)
ASC  A 501 (-3.4A)
ASC  A 501 (-4.1A)
 0.18A 4rp8C-4rp8A:
59.7		 4rp8C-4rp8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 ILE A 215
HIS A 212
ILE A 189
ALA A 153
PHE A 207
 None
 1.24A 4rp8C-4rxlA:
undetectable		 4rp8C-4rxlA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A  37
GLN A  55
ILE A 105
ALA A 107
PHE A  72
 None
 1.02A 4rp8C-4um8A:
undetectable		 4rp8C-4um8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C) 		5 THR A 108
ILE A 126
GLN A  72
ALA A 172
ILE A  49
 None
 1.09A 4rp8C-4whoA:
undetectable		 4rp8C-4whoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 5 LEU A  83
ILE A  59
HIS A 311
ILE A 193
PHE A 308
 None
 1.22A 4rp8C-5a0kA:
1.1		 4rp8C-5a0kA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		5 LEU A 397
ILE A 498
ILE A 402
ALA A 405
ILE A 381
 None
 1.14A 4rp8C-5bu1A:
undetectable		 4rp8C-5bu1A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 HIS A 285
ILE A 366
HIS A 321
ALA A 289
ILE A 164
 KCX  A 191 ( 3.7A)
None
KCX  A 191 ( 3.5A)
None
KCX  A 191 ( 4.1A)
 1.15A 4rp8C-5c2cA:
undetectable		 4rp8C-5c2cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 146
THR A 391
ILE A 366
HIS A 285
ALA A 259
 None
KCX  A 191 ( 2.9A)
None
KCX  A 191 ( 3.7A)
None
 1.25A 4rp8C-5c2cA:
undetectable		 4rp8C-5c2cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 261
ILE A 366
HIS A 321
ALA A 289
ILE A 164
 KCX  A 191 ( 4.4A)
None
KCX  A 191 ( 3.5A)
None
KCX  A 191 ( 4.1A)
 1.24A 4rp8C-5c2cA:
undetectable		 4rp8C-5c2cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		5 ILE A 109
HIS A  65
ILE A  54
PHE A  30
MET A  62
 None
PCA  A 403 (-3.9A)
None
PCA  A 403 (-4.1A)
PCA  A 403 ( 4.9A)
 1.05A 4rp8C-5cadA:
undetectable		 4rp8C-5cadA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cc8 THIAMINE-MONOPHOSPHA
TE KINASE

(Acinetobacter
baumannii) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		6 LEU A 114
THR A 119
ILE A   7
ILE A 103
ILE A  86
PHE A  99
 ANP  A 401 ( 4.6A)
ANP  A 401 (-3.9A)
ANP  A 401 (-4.0A)
None
ANP  A 401 ( 4.8A)
None
 1.38A 4rp8C-5cc8A:
undetectable		 4rp8C-5cc8A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 LEU A 797
HIS A 766
ILE A 849
ALA A 802
PHE A 863
 None
 1.12A 4rp8C-5d0fA:
undetectable		 4rp8C-5d0fA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di0 NATTERIN-LIKE
PROTEIN

(Danio rerio) 		PF03318
(ETX_MTX2) 		5 LEU A  88
ILE A   9
ILE A  91
ILE A 126
PHE A 139
 None
PEG  A 408 (-4.3A)
None
None
None
 1.06A 4rp8C-5di0A:
undetectable		 4rp8C-5di0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		6 LEU A 194
ILE A 150
ILE A 202
ALA A  71
PHE A  68
MET A 181
 None
 1.34A 4rp8C-5f83A:
undetectable		 4rp8C-5f83A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 LEU B 170
GLN B 134
ILE B 119
ILE B  96
PHE B 132
 None
 0.97A 4rp8C-5fozB:
undetectable		 4rp8C-5fozB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 147
THR A 392
ILE A 367
HIS A 286
ALA A 260
 None
KCX  A 192 ( 3.1A)
None
KCX  A 192 ( 3.5A)
None
 1.18A 4rp8C-5hqlA:
undetectable		 4rp8C-5hqlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 262
ILE A 367
HIS A 322
ALA A 290
ILE A 165
 KCX  A 192 ( 4.1A)
None
KCX  A 192 (-3.8A)
None
KCX  A 192 (-3.7A)
 1.25A 4rp8C-5hqlA:
undetectable		 4rp8C-5hqlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy3 MRNA
ENDORIBONUCLEASE
LSOA

(Escherichia
coli) 		PF15935
(RnlA_toxin) 		5 ILE A 118
ILE A 152
ALA A 144
ILE A 165
PHE A 154
 None
 1.21A 4rp8C-5hy3A:
undetectable		 4rp8C-5hy3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Acinetobacter
baumannii) 		PF00005
(ABC_tran) 		5 LEU A  70
ILE A 252
GLN A 255
ILE A 229
PHE A  41
 None
 1.13A 4rp8C-5idvA:
undetectable		 4rp8C-5idvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 262
THR A 422
ILE A 397
HIS A 322
ILE A 165
 None
KCX  A 193 ( 3.7A)
None
CAP  A 501 (-4.0A)
CAP  A 501 (-3.7A)
 1.19A 4rp8C-5macA:
undetectable		 4rp8C-5macA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Caenorhabditis
elegans) 		no annotation 6 LEU A  92
ILE A  69
GLN A  75
HIS A  96
ILE A 143
PHE A 145
 None
NAP  A 301 (-3.7A)
None
None
None
None
 1.25A 4rp8C-5ojiA:
undetectable		 4rp8C-5ojiA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4q DTDP-GLUCOSE
4,6-DEHYDRATASE

(Klebsiella
pneumoniae) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 176
ILE A  80
ILE A 260
ALA A 226
ILE A  12
 None
None
None
None
NAD  A 401 (-3.9A)
 1.10A 4rp8C-5u4qA:
undetectable		 4rp8C-5u4qA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 5 ILE A 109
HIS A  65
ILE A  54
PHE A  30
MET A  62
 None
 1.05A 4rp8C-5vf5A:
undetectable		 4rp8C-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		no annotation 5 THR A 245
ILE A 213
ILE A 292
ALA A 236
PHE A 241
 None
 1.11A 4rp8C-5yg7A:
undetectable		 4rp8C-5yg7A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5zov -

(-) 		no annotation 9 HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ALA A 316
ILE A 358
PHE A 362
MET A 415
 ASC  A 501 (-4.0A)
None
ASC  A 501 (-3.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-4.2A)
ASC  A 501 (-3.6A)
ASC  A 501 ( 4.9A)
ASC  A 501 (-3.8A)
ASC  A 501 ( 4.6A)
 0.35A 4rp8C-5zovA:
44.7		 4rp8C-5zovA:
62.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 5 LEU A 131
THR A 112
ILE A 110
ALA A 170
ILE A  97
 None
 1.12A 4rp8C-6d6vA:
undetectable		 4rp8C-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehi NUCLEASE NUCT

(Helicobacter
pylori) 		no annotation 5 LEU A  17
ILE A 106
ILE A  40
ALA A  43
ILE A  30
 None
 0.98A 4rp8C-6ehiA:
undetectable		 4rp8C-6ehiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD

(Acetobacterium
woodii) 		no annotation 5 LEU B 176
ILE B 148
ALA B 155
ILE B  48
MET B   1
 None
 1.24A 4rp8C-6fahB:
undetectable		 4rp8C-6fahB:
undetectable