SIMILAR PATTERNS OF AMINO ACIDS FOR 4RP8_C_ASCC501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		5 LEU A 150
ILE A 275
ILE A   8
ILE A  28
PHE A  25
 None
 1.23A 4rp8C-1a7jA:
0.0		 4rp8C-1a7jA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyw CAFFEIC ACID
3-O-METHYLTRANSFERAS
E

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A 192
ILE A 225
ILE A 191
ILE A 294
PHE A 263
 None
 1.11A 4rp8C-1kywA:
0.0		 4rp8C-1kywA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 LEU A 343
THR A 215
ILE A 184
ALA A 202
PHE A 208
 None
 1.14A 4rp8C-1lnlA:
0.0		 4rp8C-1lnlA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvf IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION

(Camelus
dromedarius) 		PF07686
(V-set) 		5 ILE A  53
GLN A  72
ILE A  59
ALA A 107
ILE A  70
 None
 1.10A 4rp8C-1mvfA:
undetectable		 4rp8C-1mvfA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A 445
ILE A 438
ILE A 109
ILE A 464
MET A 473
 None
 1.07A 4rp8C-1obbA:
0.0		 4rp8C-1obbA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzs SUPEROXIDE DISMUTASE
[CU-ZN]

(Mycobacterium
tuberculosis) 		PF00080
(Sod_Cu) 		5 LEU A  46
THR A 107
ILE A 123
ALA A  18
PHE A  20
 None
 1.17A 4rp8C-1pzsA:
0.0		 4rp8C-1pzsA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		5 LEU A 257
THR A 282
ILE A 274
ALA A 312
ILE A 286
 None
 1.22A 4rp8C-1q6yA:
0.0		 4rp8C-1q6yA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 LEU A 282
ILE A 227
ILE A 322
ILE A 125
PHE A 252
 None
 1.13A 4rp8C-1qhoA:
0.0		 4rp8C-1qhoA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri6 PUTATIVE ISOMERASE
YBHE

(Escherichia
coli) 		PF10282
(Lactonase) 		5 LEU A 313
THR A 239
ILE A 255
ALA A 293
PHE A 282
 None
 1.25A 4rp8C-1ri6A:
undetectable		 4rp8C-1ri6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vio RIBOSOMAL SMALL
SUBUNIT
PSEUDOURIDINE
SYNTHASE A

(Haemophilus
influenzae) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		5 LEU A 166
THR A 161
ILE A 178
GLN A 185
ILE A 152
 None
 1.03A 4rp8C-1vioA:
undetectable		 4rp8C-1vioA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG

(Clostridium
acetobutylicum) 		PF04321
(RmlD_sub_bind) 		5 ILE A 275
GLN A 279
ALA A 218
ILE A 227
PHE A 222
 None
 1.14A 4rp8C-1vl0A:
undetectable		 4rp8C-1vl0A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjl ANNEXIN A2

(Homo sapiens) 		PF00191
(Annexin) 		5 LEU A 174
ILE A 263
ALA A 255
PHE A 256
MET A 240
 None
 1.16A 4rp8C-1xjlA:
undetectable		 4rp8C-1xjlA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg) 		5 LEU A 108
ILE A   6
ILE A 105
ALA A  20
PHE A  16
 None
 1.06A 4rp8C-1zh4A:
undetectable		 4rp8C-1zh4A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ado MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1

(Homo sapiens) 		PF16770
(RTT107_BRCT_5) 		5 LEU A1987
ILE A1947
ALA A1940
ILE A1931
PHE A1937
 None
 1.21A 4rp8C-2adoA:
undetectable		 4rp8C-2adoA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctm VIGILIN

(Homo sapiens) 		PF00013
(KH_1) 		5 LEU A  82
HIS A  78
ILE A  31
ALA A  38
ILE A  50
 None
 0.99A 4rp8C-2ctmA:
undetectable		 4rp8C-2ctmA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5u N-GLYCANASE 1

(Mus musculus) 		PF09409
(PUB) 		5 LEU A  48
ILE A 106
GLN A 102
ILE A  47
PHE A  85
 None
 1.12A 4rp8C-2d5uA:
undetectable		 4rp8C-2d5uA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 HIS A 149
ILE A 150
ALA A 108
ILE A  92
PHE A  88
 None
 1.12A 4rp8C-2dy3A:
undetectable		 4rp8C-2dy3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		6 LEU A 334
ILE A 167
GLN A 208
ILE A 330
ILE A 218
PHE A 209
 None
 1.40A 4rp8C-2e87A:
2.2		 4rp8C-2e87A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		5 LEU A 207
GLN A 186
GLN A 187
ALA A 195
MET A 166
 None
 1.10A 4rp8C-2f5xA:
undetectable		 4rp8C-2f5xA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		5 LEU A  42
THR A  74
ILE A  99
ALA A  87
ILE A  19
 None
 0.96A 4rp8C-2hcuA:
undetectable		 4rp8C-2hcuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hro PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Staphylococcus
carnosus) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		5 LEU A 519
THR A 454
ILE A 482
ILE A 490
ILE A 452
 None
 1.22A 4rp8C-2hroA:
undetectable		 4rp8C-2hroA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Saccharomyces
cerevisiae;
Aequorea
victoria) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		5 HIS A 330
ILE A 331
ALA A 268
ILE A 260
PHE A 266
 None
 1.13A 4rp8C-2jadA:
undetectable		 4rp8C-2jadA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q34 CURF

(Moorea
producens) 		PF00378
(ECH_1) 		5 LEU A 122
ILE A  45
ILE A 100
ILE A  30
PHE A  53
 None
 1.19A 4rp8C-2q34A:
undetectable		 4rp8C-2q34A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbg PUTATIVE
UNCHARACTERIZED
PROTEIN ST0493

(Sulfurisphaera
tokodaii) 		no annotation 5 LEU A  69
ILE A  38
ILE A  44
ILE A  53
PHE A  17
 None
 1.25A 4rp8C-2rbgA:
undetectable		 4rp8C-2rbgA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 LEU B 386
THR B 263
HIS B 388
GLN B 265
ILE B 279
 None
 1.14A 4rp8C-2uzxB:
undetectable		 4rp8C-2uzxB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1l HYPOTHETICAL PROTEIN

(Vibrio cholerae) 		PF10980
(DUF2787) 		5 LEU A  64
THR A   9
HIS A  18
ILE A  62
PHE A  17
 None
 1.14A 4rp8C-2v1lA:
undetectable		 4rp8C-2v1lA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 THR A 344
ILE A 396
GLN A  49
ILE A  11
PHE A 298
 None
 1.24A 4rp8C-2zktA:
undetectable		 4rp8C-2zktA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		6 LEU C 163
ILE C 176
ILE C 217
ALA C 134
ILE C 143
PHE C 139
 None
 1.41A 4rp8C-3aizC:
undetectable		 4rp8C-3aizC:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		5 LEU A 108
ILE A  98
ILE A 113
ALA A 234
ILE A 243
 None
 0.80A 4rp8C-3ax6A:
undetectable		 4rp8C-3ax6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		5 LEU A 126
THR A 158
ILE A 133
ILE A 171
ILE A 138
 None
None
GOL  A 209 ( 4.7A)
None
None
 1.20A 4rp8C-3bbhA:
undetectable		 4rp8C-3bbhA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 HIS A 155
HIS A 145
ILE A 116
ALA A 114
ILE A 153
 ZN  A 503 ( 3.3A)
ZN  A 503 ( 3.3A)
None
None
None
 1.25A 4rp8C-3dslA:
undetectable		 4rp8C-3dslA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 LEU A 422
THR A 391
ILE A 316
ILE A 411
ALA A 407
 None
 1.24A 4rp8C-3eh7A:
undetectable		 4rp8C-3eh7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3get HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF00155
(Aminotran_1_2) 		5 LEU A 221
GLN A  92
ALA A  97
ILE A  85
PHE A 248
 None
 1.23A 4rp8C-3getA:
undetectable		 4rp8C-3getA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		5 LEU A 262
ILE A 314
ALA A 307
ILE A 242
PHE A 239
 None
 1.23A 4rp8C-3hjlA:
undetectable		 4rp8C-3hjlA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B  39
ILE B 394
ILE B  43
ILE B 116
PHE B 358
 None
 1.23A 4rp8C-3hkzB:
undetectable		 4rp8C-3hkzB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 LEU A 639
ILE A 619
ILE A 634
ILE A 691
PHE A 687
 None
 1.19A 4rp8C-3ibjA:
1.4		 4rp8C-3ibjA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5h PHOSPHORIBOSYL-AMINO
IMIDAZOLE
CARBOXYLASE

(Aspergillus
clavatus) 		PF01262
(AlaDh_PNT_C)
PF02222
(ATP-grasp) 		5 THR A 279
ILE A 193
GLN A 287
ILE A 300
ALA A 294
 None
 1.25A 4rp8C-3k5hA:
undetectable		 4rp8C-3k5hA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klj NAD(FAD)-DEPENDENT
DEHYDROGENASE,
NIRB-FAMILY
(N-TERMINAL DOMAIN)

(Clostridium
acetobutylicum) 		PF07992
(Pyr_redox_2) 		5 LEU A 102
THR A 233
ALA A  79
ILE A 230
PHE A 229
 None
None
FAD  A 401 (-3.7A)
None
FAD  A 401 (-4.4A)
 1.16A 4rp8C-3kljA:
undetectable		 4rp8C-3kljA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mal STROMAL CELL-DERIVED
FACTOR 2-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF02815
(MIR) 		5 ILE A 150
GLN A 161
ILE A 105
ALA A 103
ILE A  37
 None
SO4  A   1 (-4.0A)
None
None
None
 1.24A 4rp8C-3malA:
undetectable		 4rp8C-3malA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 THR B 157
ILE B 250
ILE B 256
ALA B 208
ILE B 152
 None
 0.97A 4rp8C-3mcaB:
undetectable		 4rp8C-3mcaB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtx PROTEIN MD-1

(Gallus gallus) 		PF02221
(E1_DerP2_DerF2) 		5 LEU A 123
ILE A  63
ILE A 135
ALA A 137
ILE A  35
 None
None
PGT  A 300 (-4.7A)
PGT  A 300 ( 3.9A)
PGT  A 300 ( 4.6A)
 1.09A 4rp8C-3mtxA:
undetectable		 4rp8C-3mtxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohe HISTIDINE TRIAD
(HIT) PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF01230
(HIT) 		5 LEU A  57
GLN A  88
ILE A  46
ALA A  81
ILE A  43
 None
 1.20A 4rp8C-3oheA:
undetectable		 4rp8C-3oheA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr7 URACIL-DNA
GLYCOSYLASE

(Coxiella
burnetii) 		PF03167
(UDG) 		5 ILE A  47
GLN A  44
ILE A 141
ALA A 127
ILE A  40
 None
 1.10A 4rp8C-3tr7A:
undetectable		 4rp8C-3tr7A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		5 LEU A 194
ILE A  21
HIS A 234
ILE A 193
ILE A 284
 HEC  A1001 ( 3.7A)
SO4  A 534 ( 3.9A)
HEC  A1002 (-3.1A)
HEC  A1002 (-4.1A)
None
 1.03A 4rp8C-3ttbA:
2.8		 4rp8C-3ttbA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		5 LEU A 133
ILE A 107
ILE A 169
ALA A 172
PHE A 173
 None
 1.18A 4rp8C-3ujpA:
1.4		 4rp8C-3ujpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usw FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 LEU A 271
ILE A 323
ALA A 316
ILE A 251
PHE A 248
 None
 1.18A 4rp8C-3uswA:
undetectable		 4rp8C-3uswA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usy FLAGELLAR MOTOR
SWITCH PROTEIN

(Helicobacter
pylori) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 LEU A 271
ILE A 323
ALA A 316
ILE A 251
PHE A 248
 None
 1.17A 4rp8C-3usyA:
undetectable		 4rp8C-3usyA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		5 LEU A 377
ILE A 267
ILE A 373
ALA A 189
PHE A 190
 None
 0.78A 4rp8C-3vs8A:
undetectable		 4rp8C-3vs8A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 LEU A 170
GLN A 134
ILE A 119
ILE A  96
PHE A 132
 None
 1.00A 4rp8C-3wa1A:
undetectable		 4rp8C-3wa1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 ILE B1013
GLN B1115
ILE B1073
ALA B1003
PHE B1112
 None
 1.05A 4rp8C-3zefB:
undetectable		 4rp8C-3zefB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 ILE A 632
GLN A 583
ILE A 604
ALA A 607
PHE A 635
 None
 1.12A 4rp8C-3ziuA:
undetectable		 4rp8C-3ziuA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		5 LEU A 198
ILE A 290
ILE A 200
ALA A 351
ILE A 331
 None
 1.25A 4rp8C-4a1fA:
3.4		 4rp8C-4a1fA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF01058
(Oxidored_q6) 		5 LEU B 199
ILE B 254
GLN B 258
ALA B 134
ILE B 177
 None
SF4  B1275 ( 4.6A)
None
None
None
 1.21A 4rp8C-4ci0B:
undetectable		 4rp8C-4ci0B:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		5 HIS A 186
ILE A 213
ILE A 241
ALA A 233
ILE A 487
 None
 1.09A 4rp8C-4ddqA:
1.9		 4rp8C-4ddqA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE

(Clostridioides
difficile) 		PF00155
(Aminotran_1_2) 		5 LEU A 351
ILE A 387
ILE A 367
ALA A 379
ILE A 307
 None
 1.06A 4rp8C-4dq6A:
undetectable		 4rp8C-4dq6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eay MANNONATE
DEHYDRATASE

(Escherichia
coli) 		PF03786
(UxuA) 		5 LEU A 197
THR A 111
ILE A 241
ILE A 177
PHE A 136
 None
 1.20A 4rp8C-4eayA:
undetectable		 4rp8C-4eayA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ese FMN-DEPENDENT
NADH-AZOREDUCTASE

(Yersinia pestis) 		PF02525
(Flavodoxin_2) 		5 LEU A   7
ILE A  48
ILE A  92
ILE A 112
PHE A 109
 None
 1.24A 4rp8C-4eseA:
undetectable		 4rp8C-4eseA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		5 ILE A 219
ILE A 189
ALA A 212
ILE A 202
PHE A 203
 None
 1.10A 4rp8C-4fdwA:
undetectable		 4rp8C-4fdwA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhr FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Thermotoga
maritima) 		PF01706
(FliG_C)
PF14841
(FliG_M) 		5 LEU B 261
ILE B 313
ALA B 306
ILE B 241
PHE B 238
 None
 1.18A 4rp8C-4fhrB:
undetectable		 4rp8C-4fhrB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi5 QUINONE REDUCTASE

(Klebsiella
pneumoniae) 		PF02525
(Flavodoxin_2) 		5 LEU A  88
ILE A   6
ALA A 147
ILE A 113
MET A 105
 None
 1.25A 4rp8C-4gi5A:
undetectable		 4rp8C-4gi5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 LEU A 332
ILE A 355
ALA A 382
ILE A 369
PHE A 383
 None
None
EDO  A 509 (-4.5A)
None
None
 1.15A 4rp8C-4h09A:
undetectable		 4rp8C-4h09A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 LEU A 639
ILE A 619
ILE A 634
ILE A 691
PHE A 687
 None
 1.05A 4rp8C-4htzA:
2.1		 4rp8C-4htzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		5 LEU A  55
ILE A  51
ALA A 205
ILE A 197
PHE A 240
 None
None
None
LLP  A 196 ( 4.0A)
None
 1.25A 4rp8C-4ixoA:
undetectable		 4rp8C-4ixoA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		5 LEU B 386
THR B 263
HIS B 388
GLN B 265
ILE B 279
 None
 1.10A 4rp8C-4k3jB:
undetectable		 4rp8C-4k3jB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kny KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A 108
ILE A   6
ILE A 105
ALA A  20
PHE A  16
 None
 0.96A 4rp8C-4knyA:
undetectable		 4rp8C-4knyA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET) 		5 LEU A 619
ILE A 721
ILE A 689
ALA A 692
PHE A 729
 None
 1.08A 4rp8C-4mi5A:
undetectable		 4rp8C-4mi5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oue PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		5 LEU A 459
ILE A 441
ILE A 390
ALA A 388
PHE A 379
 None
 1.23A 4rp8C-4oueA:
undetectable		 4rp8C-4oueA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 LEU A 401
ILE A 509
ILE A 406
ALA A 297
PHE A 294
 None
 1.19A 4rp8C-4pfwA:
undetectable		 4rp8C-4pfwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 LEU A 401
ILE A 507
ILE A 406
ALA A 297
PHE A 294
 None
 1.14A 4rp8C-4pfyA:
undetectable		 4rp8C-4pfyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 5 LEU B 298
ILE B 306
ILE B 254
ALA B 236
ILE B 232
 None
 1.14A 4rp8C-4pl2B:
undetectable		 4rp8C-4pl2B:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
F

(Thermococcus
kodakarensis) 		PF03874
(RNA_pol_Rpb4) 		5 LEU F  66
ILE F 112
ILE F  73
ILE F  95
PHE F  96
 None
 1.19A 4rp8C-4qiwF:
undetectable		 4rp8C-4qiwF:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 5 LEU B 425
THR B 419
ILE B 432
ILE B 392
MET B 336
 None
None
FA5  B 701 (-4.1A)
None
FA5  B 701 (-4.2A)
 1.22A 4rp8C-4r0mB:
undetectable		 4rp8C-4r0mB:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		10 THR A  86
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ALA A 316
ILE A 358
PHE A 362
MET A 410
 ASC  A 501 (-3.3A)
ASC  A 501 (-4.1A)
None
ASC  A 501 (-2.5A)
ASC  A 501 (-4.1A)
ASC  A 501 (-4.0A)
ASC  A 501 ( 3.7A)
ASC  A 501 ( 4.9A)
ASC  A 501 (-3.4A)
ASC  A 501 (-4.1A)
 0.18A 4rp8C-4rp8A:
59.7		 4rp8C-4rp8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 ILE A 215
HIS A 212
ILE A 189
ALA A 153
PHE A 207
 None
 1.24A 4rp8C-4rxlA:
undetectable		 4rp8C-4rxlA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A  37
GLN A  55
ILE A 105
ALA A 107
PHE A  72
 None
 1.02A 4rp8C-4um8A:
undetectable		 4rp8C-4um8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4who PROTOCATECHUATE
3,4-DIOXYGENASE
ALPHA CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C) 		5 THR A 108
ILE A 126
GLN A  72
ALA A 172
ILE A  49
 None
 1.09A 4rp8C-4whoA:
undetectable		 4rp8C-4whoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 5 LEU A  83
ILE A  59
HIS A 311
ILE A 193
PHE A 308
 None
 1.22A 4rp8C-5a0kA:
1.1		 4rp8C-5a0kA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		5 LEU A 397
ILE A 498
ILE A 402
ALA A 405
ILE A 381
 None
 1.14A 4rp8C-5bu1A:
undetectable		 4rp8C-5bu1A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 HIS A 285
ILE A 366
HIS A 321
ALA A 289
ILE A 164
 KCX  A 191 ( 3.7A)
None
KCX  A 191 ( 3.5A)
None
KCX  A 191 ( 4.1A)
 1.15A 4rp8C-5c2cA:
undetectable		 4rp8C-5c2cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 146
THR A 391
ILE A 366
HIS A 285
ALA A 259
 None
KCX  A 191 ( 2.9A)
None
KCX  A 191 ( 3.7A)
None
 1.25A 4rp8C-5c2cA:
undetectable		 4rp8C-5c2cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 261
ILE A 366
HIS A 321
ALA A 289
ILE A 164
 KCX  A 191 ( 4.4A)
None
KCX  A 191 ( 3.5A)
None
KCX  A 191 ( 4.1A)
 1.24A 4rp8C-5c2cA:
undetectable		 4rp8C-5c2cA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		5 ILE A 109
HIS A  65
ILE A  54
PHE A  30
MET A  62
 None
PCA  A 403 (-3.9A)
None
PCA  A 403 (-4.1A)
PCA  A 403 ( 4.9A)
 1.05A 4rp8C-5cadA:
undetectable		 4rp8C-5cadA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cc8 THIAMINE-MONOPHOSPHA
TE KINASE

(Acinetobacter
baumannii) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		6 LEU A 114
THR A 119
ILE A   7
ILE A 103
ILE A  86
PHE A  99
 ANP  A 401 ( 4.6A)
ANP  A 401 (-3.9A)
ANP  A 401 (-4.0A)
None
ANP  A 401 ( 4.8A)
None
 1.38A 4rp8C-5cc8A:
undetectable		 4rp8C-5cc8A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 LEU A 797
HIS A 766
ILE A 849
ALA A 802
PHE A 863
 None
 1.12A 4rp8C-5d0fA:
undetectable		 4rp8C-5d0fA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di0 NATTERIN-LIKE
PROTEIN

(Danio rerio) 		PF03318
(ETX_MTX2) 		5 LEU A  88
ILE A   9
ILE A  91
ILE A 126
PHE A 139
 None
PEG  A 408 (-4.3A)
None
None
None
 1.06A 4rp8C-5di0A:
undetectable		 4rp8C-5di0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f83 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		6 LEU A 194
ILE A 150
ILE A 202
ALA A  71
PHE A  68
MET A 181
 None
 1.34A 4rp8C-5f83A:
undetectable		 4rp8C-5f83A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		5 LEU B 170
GLN B 134
ILE B 119
ILE B  96
PHE B 132
 None
 0.97A 4rp8C-5fozB:
undetectable		 4rp8C-5fozB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 147
THR A 392
ILE A 367
HIS A 286
ALA A 260
 None
KCX  A 192 ( 3.1A)
None
KCX  A 192 ( 3.5A)
None
 1.18A 4rp8C-5hqlA:
undetectable		 4rp8C-5hqlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 262
ILE A 367
HIS A 322
ALA A 290
ILE A 165
 KCX  A 192 ( 4.1A)
None
KCX  A 192 (-3.8A)
None
KCX  A 192 (-3.7A)
 1.25A 4rp8C-5hqlA:
undetectable		 4rp8C-5hqlA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy3 MRNA
ENDORIBONUCLEASE
LSOA

(Escherichia
coli) 		PF15935
(RnlA_toxin) 		5 ILE A 118
ILE A 152
ALA A 144
ILE A 165
PHE A 154
 None
 1.21A 4rp8C-5hy3A:
undetectable		 4rp8C-5hy3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Acinetobacter
baumannii) 		PF00005
(ABC_tran) 		5 LEU A  70
ILE A 252
GLN A 255
ILE A 229
PHE A  41
 None
 1.13A 4rp8C-5idvA:
undetectable		 4rp8C-5idvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 262
THR A 422
ILE A 397
HIS A 322
ILE A 165
 None
KCX  A 193 ( 3.7A)
None
CAP  A 501 (-4.0A)
CAP  A 501 (-3.7A)
 1.19A 4rp8C-5macA:
undetectable		 4rp8C-5macA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Caenorhabditis
elegans) 		no annotation 6 LEU A  92
ILE A  69
GLN A  75
HIS A  96
ILE A 143
PHE A 145
 None
NAP  A 301 (-3.7A)
None
None
None
None
 1.25A 4rp8C-5ojiA:
undetectable		 4rp8C-5ojiA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4q DTDP-GLUCOSE
4,6-DEHYDRATASE

(Klebsiella
pneumoniae) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 176
ILE A  80
ILE A 260
ALA A 226
ILE A  12
 None
None
None
None
NAD  A 401 (-3.9A)
 1.10A 4rp8C-5u4qA:
undetectable		 4rp8C-5u4qA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 5 ILE A 109
HIS A  65
ILE A  54
PHE A  30
MET A  62
 None
 1.05A 4rp8C-5vf5A:
undetectable		 4rp8C-5vf5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		no annotation 5 THR A 245
ILE A 213
ILE A 292
ALA A 236
PHE A 241
 None
 1.11A 4rp8C-5yg7A:
undetectable		 4rp8C-5yg7A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5zov -

(-) 		no annotation 9 HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ALA A 316
ILE A 358
PHE A 362
MET A 415
 ASC  A 501 (-4.0A)
None
ASC  A 501 (-3.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-4.2A)
ASC  A 501 (-3.6A)
ASC  A 501 ( 4.9A)
ASC  A 501 (-3.8A)
ASC  A 501 ( 4.6A)
 0.35A 4rp8C-5zovA:
44.7		 4rp8C-5zovA:
62.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		no annotation 5 LEU A 131
THR A 112
ILE A 110
ALA A 170
ILE A  97
 None
 1.12A 4rp8C-6d6vA:
undetectable		 4rp8C-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehi NUCLEASE NUCT

(Helicobacter
pylori) 		no annotation 5 LEU A  17
ILE A 106
ILE A  40
ALA A  43
ILE A  30
 None
 0.98A 4rp8C-6ehiA:
undetectable		 4rp8C-6ehiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD

(Acetobacterium
woodii) 		no annotation 5 LEU B 176
ILE B 148
ALA B 155
ILE B  48
MET B   1
 None
 1.24A 4rp8C-6fahB:
undetectable		 4rp8C-6fahB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		3 SER A  40
TYR A  38
ASP A 131
 None
 0.75A 4rp8C-1ct9A:
0.0		 4rp8C-1ct9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		3 SER A 299
TYR A 320
ASP A 292
 None
None
PLP  A 342 ( 4.5A)
 0.80A 4rp8C-1f2dA:
0.0		 4rp8C-1f2dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		3 SER A 218
TYR A 147
ASP A  22
 None
None
ZN  A 401 ( 2.2A)
 0.70A 4rp8C-1ituA:
0.0		 4rp8C-1ituA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 SER A 172
TYR A 176
ASP A  61
 NGA  A 870 (-2.6A)
None
NGA  A 870 (-2.9A)
 0.89A 4rp8C-1ktcA:
0.0		 4rp8C-1ktcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		3 SER B 247
TYR B 249
ASP B 243
 None
None
BPY  B 401 (-3.9A)
 0.88A 4rp8C-1kwcB:
0.0		 4rp8C-1kwcB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		3 SER A 248
TYR A 250
ASP A 244
 None
P6G  A 600 ( 3.7A)
BP6  A 300 ( 4.4A)
 0.83A 4rp8C-1lkdA:
0.0		 4rp8C-1lkdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0z SENSOR KINASE CITA

(Klebsiella
pneumoniae) 		PF17203
(sCache_3_2) 		3 SER A 105
TYR A  56
ASP A  83
 None
FLC  A1632 (-3.8A)
OMO  A1631 (-3.9A)
 0.83A 4rp8C-1p0zA:
0.0		 4rp8C-1p0zA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		3 SER A 187
TYR A 191
ASP A  88
 None
None
ZN  A 270 (-2.4A)
 0.79A 4rp8C-1smlA:
0.0		 4rp8C-1smlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		3 SER A 201
TYR A 128
ASP A 257
 None
 0.74A 4rp8C-1sznA:
0.0		 4rp8C-1sznA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pseudomonas sp.
ACP) 		PF00291
(PALP) 		3 SER A 298
TYR A 319
ASP A 291
 None
None
PLP  A 401 ( 4.9A)
 0.77A 4rp8C-1tzmA:
undetectable		 4rp8C-1tzmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 SER A 160
TYR A 126
ASP A 216
 None
None
GLA  A1501 ( 4.4A)
 0.75A 4rp8C-1uasA:
undetectable		 4rp8C-1uasA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		3 SER A  60
TYR A  32
ASP A  80
 GLU  A1313 (-2.6A)
GLU  A1313 (-3.7A)
None
 0.73A 4rp8C-1us4A:
undetectable		 4rp8C-1us4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I

(Thermoproteus
tenax) 		PF01791
(DeoC) 		3 SER A  92
TYR A 114
ASP A  24
 None
None
FBP  A 270 (-2.8A)
 0.85A 4rp8C-1w8sA:
undetectable		 4rp8C-1w8sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		3 SER A 104
TYR A 106
ASP A 292
 None
 0.73A 4rp8C-1wyeA:
2.1		 4rp8C-1wyeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 SER A 967
TYR A 930
ASP A 801
 None
 0.86A 4rp8C-1xc6A:
undetectable		 4rp8C-1xc6A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		3 SER A 229
TYR A 196
ASP A  40
 None
 0.66A 4rp8C-1xvxA:
undetectable		 4rp8C-1xvxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		3 SER A 226
TYR A 193
ASP A  37
 None
 0.68A 4rp8C-1xvyA:
undetectable		 4rp8C-1xvyA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 SER A 130
TYR A 132
ASP A 167
 None
 0.90A 4rp8C-1y9gA:
undetectable		 4rp8C-1y9gA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 SER A 251
TYR A 263
ASP A  90
 None
 0.86A 4rp8C-2b2cA:
undetectable		 4rp8C-2b2cA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cl8 DECTIN-1

(Mus musculus) 		PF00059
(Lectin_C) 		3 SER A 129
TYR A 131
ASP A 158
 CA  A1245 ( 4.8A)
None
CA  A1245 (-3.3A)
 0.81A 4rp8C-2cl8A:
undetectable		 4rp8C-2cl8A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		3 SER A 467
TYR A 471
ASP A 442
 None
 0.88A 4rp8C-2e0pA:
undetectable		 4rp8C-2e0pA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		3 SER A  78
TYR A  76
ASP A  82
 None
 0.89A 4rp8C-2ewyA:
undetectable		 4rp8C-2ewyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9k MODIFICATION
METHYLASE HHAI

(Haemophilus
haemolyticus) 		PF00145
(DNA_methylase) 		3 SER A 305
TYR A 285
ASP A  16
 SAH  A 328 (-2.7A)
None
None
 0.90A 4rp8C-2i9kA:
undetectable		 4rp8C-2i9kA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 SER A 512
TYR A 507
ASP A 598
 None
 0.85A 4rp8C-2iujA:
undetectable		 4rp8C-2iujA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbi HEP200 PROTEIN

(Cylindrotheca
fusiformis) 		no annotation 3 SER A 125
TYR A 117
ASP A 156
 None
 0.89A 4rp8C-2nbiA:
undetectable		 4rp8C-2nbiA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ULTRASPIRACLE (USP,
NR2B4)
ECDYSONE RECEPTOR
(ECR, NRH1)

(Tribolium
castaneum;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF00104
(Hormone_recep) 		3 SER E 509
TYR A 343
ASP A 325
 None
 0.82A 4rp8C-2nxxE:
undetectable		 4rp8C-2nxxE:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p90 HYPOTHETICAL PROTEIN
CGL1923

(Corynebacterium
glutamicum) 		PF09754
(PAC2) 		3 SER A 195
TYR A 197
ASP A 161
 None
 0.88A 4rp8C-2p90A:
undetectable		 4rp8C-2p90A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		3 SER B 256
TYR B 266
ASP B 260
 None
 0.65A 4rp8C-2pbiB:
undetectable		 4rp8C-2pbiB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		3 SER A 173
TYR A 186
ASP A 134
 None
 0.82A 4rp8C-2pxxA:
undetectable		 4rp8C-2pxxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN

(Prochlorococcus
phage P-SSM2) 		PF05996
(Fe_bilin_red) 		3 SER A  84
TYR A 211
ASP A  58
 None
GOL  A1235 ( 4.7A)
None
 0.77A 4rp8C-2vclA:
undetectable		 4rp8C-2vclA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc7 ALPHA AMYLASE,
CATALYTIC REGION

(Nostoc
punctiforme) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 SER A 321
TYR A 260
ASP A 122
 None
 0.90A 4rp8C-2wc7A:
undetectable		 4rp8C-2wc7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 SER A  25
TYR A  23
ASP A 125
 None
 0.86A 4rp8C-2x4dA:
undetectable		 4rp8C-2x4dA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		3 SER A 556
TYR A 552
ASP A 609
 None
 0.84A 4rp8C-2x6kA:
undetectable		 4rp8C-2x6kA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		3 SER A  93
TYR A  90
ASP A 158
 None
 0.83A 4rp8C-2yg6A:
undetectable		 4rp8C-2yg6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6b BASEPLATE STRUCTURAL
PROTEIN GP27

(Escherichia
virus T4) 		PF09096
(Phage-tail_2)
PF09097
(Phage-tail_1) 		3 SER D 131
TYR D 169
ASP D 159
 None
 0.81A 4rp8C-2z6bD:
undetectable		 4rp8C-2z6bD:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		3 SER A 164
TYR A 125
ASP A 240
 None
 0.87A 4rp8C-3a5vA:
undetectable		 4rp8C-3a5vA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		3 SER A 187
TYR A  72
ASP A  79
 None
 0.90A 4rp8C-3ag6A:
2.2		 4rp8C-3ag6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agb RED CHLOROPHYLL
CATABOLITE
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06405
(RCC_reductase) 		3 SER A 209
TYR A 207
ASP A 291
 None
 0.85A 4rp8C-3agbA:
undetectable		 4rp8C-3agbA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		3 SER A  76
TYR A  78
ASP A  22
 None
 0.81A 4rp8C-3cnyA:
undetectable		 4rp8C-3cnyA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		3 SER A 303
TYR A 301
ASP A 346
 None
 0.73A 4rp8C-3drkA:
undetectable		 4rp8C-3drkA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fm0 PROTEIN CIAO1

(Homo sapiens) 		PF00400
(WD40) 		3 SER A 167
TYR A 177
ASP A 171
 None
 0.64A 4rp8C-3fm0A:
undetectable		 4rp8C-3fm0A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		3 SER A 283
TYR A  68
ASP A  41
 None
 0.84A 4rp8C-3gfvA:
0.8		 4rp8C-3gfvA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		3 SER A 186
TYR A  71
ASP A  78
 ATP  A 300 ( 4.9A)
None
None
 0.89A 4rp8C-3innA:
undetectable		 4rp8C-3innA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j82 C-TYPE LECTIN DOMAIN
FAMILY 9 MEMBER A

(Mus musculus) 		PF00059
(Lectin_C) 		3 SER A 147
TYR A 149
ASP A 176
 CA  A 301 ( 4.1A)
None
CA  A 301 ( 4.1A)
 0.68A 4rp8C-3j82A:
undetectable		 4rp8C-3j82A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhn LIPOPROTEIN

(Shewanella
oneidensis) 		PF04170
(NlpE) 		3 SER A  85
TYR A  87
ASP A 114
 None
 0.75A 4rp8C-3lhnA:
undetectable		 4rp8C-3lhnA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow8 WD REPEAT-CONTAINING
PROTEIN 61

(Homo sapiens) 		PF00400
(WD40) 		3 SER A 291
TYR A 301
ASP A 295
 None
 0.85A 4rp8C-3ow8A:
undetectable		 4rp8C-3ow8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr4 DNA POLYMERASE IV

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		3 SER A 145
TYR A 118
ASP A 231
 None
 0.84A 4rp8C-3pr4A:
2.0		 4rp8C-3pr4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q10 PANTOATE--BETA-ALANI
NE LIGASE

(Yersinia pestis) 		PF02569
(Pantoate_ligase) 		3 SER A 188
TYR A  71
ASP A  78
 AMP  A 501 ( 4.9A)
None
None
 0.84A 4rp8C-3q10A:
undetectable		 4rp8C-3q10A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor) 		PF01244
(Peptidase_M19) 		3 SER A 211
TYR A 145
ASP A  22
 None
None
ZN  A 402 ( 2.2A)
 0.77A 4rp8C-3s2jA:
undetectable		 4rp8C-3s2jA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF02569
(Pantoate_ligase) 		3 SER A 183
TYR A  67
ASP A  74
 None
 0.80A 4rp8C-3uk2A:
undetectable		 4rp8C-3uk2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukn NOVEL PROTEIN
SIMILAR TO
VERTEBRATE POTASSIUM
VOLTAGE-GATED
CHANNEL, SUBFAMILY H
(EAG-RELATED) FAMILY

(Danio rerio) 		PF00027
(cNMP_binding) 		3 SER A 631
TYR A 723
ASP A 601
 None
 0.85A 4rp8C-3uknA:
undetectable		 4rp8C-3uknA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uy4 PANTOTHENATE
SYNTHETASE

(Campylobacter
jejuni) 		PF02569
(Pantoate_ligase) 		3 SER A 185
TYR A  70
ASP A  77
 AMP  A 301 ( 4.9A)
None
None
 0.87A 4rp8C-3uy4A:
2.1		 4rp8C-3uy4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6o LEPTIN RECEPTOR
MONOCLONAL ANTIBODY
9F8 FAB FRAGMENT
HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation
PF07654
(C1-set)
PF07686
(V-set) 		3 SER A 507
TYR A 509
ASP C  34
 None
None
ACT  C 301 (-2.8A)
 0.75A 4rp8C-3v6oA:
undetectable		 4rp8C-3v6oA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		3 SER A 479
TYR A 420
ASP A 448
 None
 0.89A 4rp8C-3vilA:
undetectable		 4rp8C-3vilA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		3 SER A 177
TYR A  66
ASP A 127
 None
 0.89A 4rp8C-3zdbA:
undetectable		 4rp8C-3zdbA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5f MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE C

(Escherichia
coli) 		PF01464
(SLT)
PF11873
(DUF3393) 		3 SER A  76
TYR A  65
ASP A 123
 None
 0.89A 4rp8C-4c5fA:
undetectable		 4rp8C-4c5fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1x PHOSPHATE-BINDING
PROTEIN PSTS 2

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		3 SER A  41
TYR A  96
ASP A  68
 None
 0.81A 4rp8C-4h1xA:
undetectable		 4rp8C-4h1xA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		3 SER L  73
TYR L 251
ASP L 122
 None
 0.81A 4rp8C-4heaL:
2.7		 4rp8C-4heaL:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		3 SER A 176
TYR A  72
ASP A 203
 None
 0.78A 4rp8C-4hwvA:
undetectable		 4rp8C-4hwvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 SER A 961
TYR A 924
ASP A 798
 None
 0.85A 4rp8C-4iugA:
undetectable		 4rp8C-4iugA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		3 SER A 308
TYR A  91
ASP A  64
 None
 0.86A 4rp8C-4jccA:
undetectable		 4rp8C-4jccA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		3 SER A 492
TYR A 502
ASP A 496
 None
 0.67A 4rp8C-4lg8A:
undetectable		 4rp8C-4lg8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgu STRUCTURAL PROTEIN
VP2

(Orthopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		3 SER A 304
TYR A 288
ASP A 403
 None
 0.90A 4rp8C-4mguA:
undetectable		 4rp8C-4mguA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN

(Vibrio cholerae) 		PF00165
(HTH_AraC) 		3 SER A 175
TYR A  26
ASP A  88
 None
 0.84A 4rp8C-4mloA:
undetectable		 4rp8C-4mloA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4moz FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Slackia
heliotrinireducens) 		PF01791
(DeoC) 		3 SER A 119
TYR A 146
ASP A  43
 None
 0.88A 4rp8C-4mozA:
undetectable		 4rp8C-4mozA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4na3 POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 SER A 600
TYR A 262
ASP A  23
 None
 0.85A 4rp8C-4na3A:
undetectable		 4rp8C-4na3A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 SER A 519
TYR A 529
ASP A 523
 None
 0.82A 4rp8C-4nsxA:
undetectable		 4rp8C-4nsxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		3 SER A  18
TYR A 319
ASP A 409
 None
 0.83A 4rp8C-4q76A:
0.8		 4rp8C-4q76A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdq BESTROPHIN-1

(Gallus gallus) 		PF01062
(Bestrophin) 		3 SER A  47
TYR A  43
ASP A 270
 None
 0.71A 4rp8C-4rdqA:
2.8		 4rp8C-4rdqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 SER A2666
TYR A2618
ASP A3343
 None
 0.81A 4rp8C-4rh7A:
undetectable		 4rp8C-4rh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		3 SER A 324
TYR A 108
ASP A 263
 NA  A 701 ( 2.4A)
TRP  A 601 (-4.8A)
NA  A 702 (-2.8A)
 0.90A 4rp8C-4us4A:
0.5		 4rp8C-4us4A:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhp PARM HYBRID FUSION
PROTEIN

(Bacillus
thuringiensis) 		no annotation 3 SER A 205
TYR A 407
ASP A 243
 None
 0.83A 4rp8C-4xhpA:
2.2		 4rp8C-4xhpA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuu PHOSPHATIDYLINOSITID
E PHOSPHATASE SAC2

(Homo sapiens) 		PF12456
(hSac2) 		3 SER A  54
TYR A  59
ASP A  23
 None
 0.81A 4rp8C-4xuuA:
undetectable		 4rp8C-4xuuA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfq L,D-TRANSPEPTIDASE 5

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		3 SER A 271
TYR A 290
ASP A 285
 None
 0.81A 4rp8C-4zfqA:
undetectable		 4rp8C-4zfqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		3 SER A 167
TYR A 291
ASP A 394
 GLC  A 501 ( 4.6A)
GLC  A 502 ( 4.2A)
GLC  A 501 ( 3.0A)
 0.89A 4rp8C-4zzeA:
undetectable		 4rp8C-4zzeA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN

(Campylobacter
jejuni) 		PF01497
(Peripla_BP_2) 		3 SER A 297
TYR A  84
ASP A  57
 None
 0.88A 4rp8C-5advA:
undetectable		 4rp8C-5advA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awp ISOMALTODEXTRANASE

(Arthrobacter
globiformis) 		no annotation 3 SER A 240
TYR A 193
ASP A 312
 None
None
BGC  A 701 ( 4.0A)
 0.65A 4rp8C-5awpA:
undetectable		 4rp8C-5awpA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 SER A 540
TYR A 621
ASP A 555
 None
 0.88A 4rp8C-5dmyA:
undetectable		 4rp8C-5dmyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gne LEUCINE
AMINOPEPTIDASE

(Legionella
pneumophila) 		PF04389
(Peptidase_M28) 		3 SER A 338
TYR A 352
ASP A 226
 ZN  A 402 ( 4.8A)
None
ZN  A 402 ( 2.8A)
 0.80A 4rp8C-5gneA:
undetectable		 4rp8C-5gneA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hg0 PANTOTHENATE
SYNTHETASE

(Francisella
tularensis) 		PF02569
(Pantoate_ligase) 		3 SER A 186
TYR A  70
ASP A  77
 SAM  A 301 ( 4.6A)
None
None
 0.86A 4rp8C-5hg0A:
undetectable		 4rp8C-5hg0A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx0 DIPEPTIDASE

(Aspergillus
fumigatus) 		PF01244
(Peptidase_M19) 		3 SER A 223
TYR A 156
ASP A  25
 None
None
FE  A 401 (-2.0A)
 0.70A 4rp8C-5lx0A:
undetectable		 4rp8C-5lx0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		3 SER A 308
TYR A 298
ASP A 161
 None
 0.86A 4rp8C-5mchA:
undetectable		 4rp8C-5mchA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP1
CAPSID SUBUNIT VP3

(Parechovirus A;
Parechovirus A) 		no annotation
no annotation 		3 SER B 144
TYR B 146
ASP A  39
 None
 0.62A 4rp8C-5mjvB:
undetectable		 4rp8C-5mjvB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzh DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Chlamydomonas
reinhardtii) 		PF00400
(WD40) 		3 SER A 322
TYR A 332
ASP A 326
 None
 0.82A 4rp8C-5mzhA:
undetectable		 4rp8C-5mzhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 SER A 341
TYR A 316
ASP A 131
 None
 0.80A 4rp8C-5ngkA:
undetectable		 4rp8C-5ngkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		3 SER A 631
TYR A 629
ASP A 604
 None
 0.77A 4rp8C-5o1pA:
undetectable		 4rp8C-5o1pA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		3 SER A 287
TYR A 292
ASP A 281
 None
 0.72A 4rp8C-5t6oA:
undetectable		 4rp8C-5t6oA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpi PUTATIVE
TRANSCRIPTIONAL
REGULATOR (LYSR
FAMILY)

(Klebsiella
pneumoniae) 		PF03466
(LysR_substrate) 		3 SER A  98
TYR A 218
ASP A 145
 CL  A 301 (-2.9A)
CL  A 301 (-4.9A)
None
 0.69A 4rp8C-5tpiA:
undetectable		 4rp8C-5tpiA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 SER A 271
TYR A 275
ASP A 250
 None
 0.83A 4rp8C-5tu0A:
1.2		 4rp8C-5tu0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		3 SER C 173
TYR C 177
ASP C 525
 None
 0.90A 4rp8C-5tw1C:
1.4		 4rp8C-5tw1C:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		3 SER A  34
TYR A 167
ASP A  27
 None
 0.65A 4rp8C-5ucdA:
undetectable		 4rp8C-5ucdA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Saccharomyces
cerevisiae) 		PF13401
(AAA_22)
PF14630
(ORC5_C) 		3 SER E 294
TYR E 250
ASP E 297
 None
 0.89A 4rp8C-5v8fE:
undetectable		 4rp8C-5v8fE:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 3 SER A 149
TYR A 143
ASP A 132
 PO4  A1202 (-2.6A)
PO4  A1202 (-4.2A)
PO4  A1205 (-4.7A)
 0.70A 4rp8C-5wivA:
undetectable		 4rp8C-5wivA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 3 SER A 610
TYR A 561
ASP A 618
 None
 0.86A 4rp8C-5xm3A:
undetectable		 4rp8C-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 3 SER A 638
TYR A 703
ASP A 685
 None
 0.87A 4rp8C-6aunA:
undetectable		 4rp8C-6aunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsu XYLOGLUCAN
6-XYLOSYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 3 SER A 157
TYR A 191
ASP A 168
 None
 0.82A 4rp8C-6bsuA:
undetectable		 4rp8C-6bsuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA
VARIABLE LYMPHOCYTE
RECEPTOR 2

(Eptatretus
burgeri;
Danio rerio;
Petromyzon
marinus) 		no annotation
no annotation 		3 SER C  58
TYR A 105
ASP C  34
 None
 0.88A 4rp8C-6bxaC:
undetectable		 4rp8C-6bxaC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dip NOCTURNIN

(Homo sapiens) 		no annotation 3 SER A 412
TYR A 410
ASP A 377
 None
 0.87A 4rp8C-6dipA:
undetectable		 4rp8C-6dipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 3 SER A 632
TYR A 630
ASP A 668
 None
 0.83A 4rp8C-6f2tA:
undetectable		 4rp8C-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4c ALPHA-GALACTOSIDASE

(Nicotiana
benthamiana) 		no annotation 3 SER B 211
TYR B 177
ASP B 267
 None
 0.67A 4rp8C-6f4cB:
undetectable		 4rp8C-6f4cB:
undetectable