SIMILAR PATTERNS OF AMINO ACIDS FOR 4RP8_A_ASCA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 THR A 138
HIS A 129
ILE A 171
ASP A 200
ALA A 202
 None
None
None
PLP  A2291 (-3.0A)
PLP  A2291 (-3.4A)
 1.40A 4rp8A-1cj0A:
0.0		 4rp8A-1cj0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 THR A 519
HIS A 513
GLN A  50
ASP A  88
ALA A  89
 None
 1.15A 4rp8A-4hozA:
0.0		 4rp8A-4hozA:
19.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA

(Escherichia
coli) 		PF03611
(EIIC-GAT) 		11 THR A  86
TYR A  87
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ASP A 314
ALA A 316
PHE A 362
MET A 410
 ASC  A 501 (-3.3A)
ASC  A 501 (-3.9A)
ASC  A 501 (-4.1A)
None
ASC  A 501 (-2.5A)
ASC  A 501 (-4.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-2.7A)
ASC  A 501 ( 3.7A)
ASC  A 501 (-3.4A)
ASC  A 501 (-4.1A)
 0.01A 4rp8A-4rp8A:
71.3		 4rp8A-4rp8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		5 THR A 279
TYR A 332
HIS A 325
ILE A 390
GLN A 235
 MG  A1612 (-2.8A)
None
None
None
None
 1.42A 4rp8A-4uopA:
0.1		 4rp8A-4uopA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		5 THR A 584
HIS A 562
GLN A 587
HIS A 451
ASP A 404
 None
FE  A 702 ( 3.4A)
None
D5M  A 701 (-4.1A)
ZN  A 703 (-2.7A)
 1.25A 4rp8A-5iheA:
0.0		 4rp8A-5iheA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		5 HIS A 258
GLN A 257
ASP A 100
ALA A 101
PHE A 198
 MG  A 300 (-3.3A)
None
MG  A 300 (-2.7A)
None
None
 1.32A 4rp8A-5vn6A:
0.0		 4rp8A-5vn6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zov -

(-) 		no annotation 10 TYR A  87
HIS A 135
ILE A 136
GLN A 139
HIS A 194
GLN A 195
ASP A 314
ALA A 316
PHE A 362
MET A 415
 ASC  A 501 (-4.0A)
ASC  A 501 (-4.0A)
None
ASC  A 501 (-3.1A)
ASC  A 501 (-4.0A)
ASC  A 501 (-4.2A)
ASC  A 501 (-2.7A)
ASC  A 501 (-3.6A)
ASC  A 501 (-3.8A)
ASC  A 501 ( 4.6A)
 0.32A 4rp8A-5zovA:
44.5		 4rp8A-5zovA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0b FRIZZLED-2

(Homo sapiens) 		no annotation 5 THR B  55
TYR B  52
ILE B  44
GLN B  66
MET B  57
 None
 1.50A 4rp8A-6c0bB:
undetectable		 4rp8A-6c0bB:
undetectable