SIMILAR PATTERNS OF AMINO ACIDS FOR 4RN6_A_15UA301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak2 ADENYLATE KINASE
ISOENZYME-2

(Bos taurus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 HIS A 208
TYR A 202
ALA A 213
ALA A 210
GLY A  23
 None
 1.24A 4rn6A-1ak2A:
0.0		 4rn6A-1ak2A:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Escherichia
coli) 		PF01182
(Glucosamine_iso) 		5 TRP A  15
LEU A 133
LEU A 229
ALA A 235
GLY A 136
 None
 1.47A 4rn6A-1fs5A:
0.0		 4rn6A-1fs5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		5 TYR A 350
LEU A 275
LEU A 481
ALA A 169
GLY A 487
 None
 1.26A 4rn6A-1gzvA:
0.0		 4rn6A-1gzvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		5 TRP A  47
LEU A 185
LEU A 224
ALA A 268
GLY A 227
 None
 1.32A 4rn6A-1hc7A:
0.0		 4rn6A-1hc7A:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		6 HIS K  57
TYR K  60
TRP K  60
LEU K  99
ALA K 190
GLY K 216
 None
 1.03A 4rn6A-1mkxK:
42.4		 4rn6A-1mkxK:
85.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		6 HIS K  57
TYR K  60
TRP K  60
LEU K  99
TRP K 215
GLY K 216
 None
 0.84A 4rn6A-1mkxK:
42.4		 4rn6A-1mkxK:
85.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfx PROTEIN (PH 2.5 ACID
PHOSPHATASE)

(Aspergillus
niger) 		PF00328
(His_Phos_2) 		5 LEU A 382
LEU A 415
ALA A 288
ALA A 295
GLY A 330
 None
 1.09A 4rn6A-1qfxA:
0.0		 4rn6A-1qfxA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz8 FAB 17B HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR B  90
LEU B  80
LEU B 100
ALA B  93
GLY B  49
 None
 0.99A 4rn6A-1rz8B:
0.0		 4rn6A-1rz8B:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		5 LEU A 116
LEU A  35
ALA A  62
ALA A  83
GLY A  38
 None
 1.38A 4rn6A-2e5fA:
undetectable		 4rn6A-2e5fA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7q BIFUNCTIONAL
3-DEHYDROQUINATE
DEHYDRATASE/SHIKIMAT
E DEHYDROGENASE

(Arabidopsis
thaliana) 		PF01487
(DHquinase_I)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 506
LEU A 468
ALA A 464
ALA A 518
GLY A 460
 None
 1.30A 4rn6A-2o7qA:
0.0		 4rn6A-2o7qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgq DOMAIN OF UNKNOWN
FUNCTION WITH A
CYSTATIN-LIKE FOLD

(Nostoc
punctiforme) 		PF13577
(SnoaL_4) 		5 HIS A  70
LEU A  90
LEU A  61
ALA A  59
ALA A  65
 None
 1.50A 4rn6A-2rgqA:
undetectable		 4rn6A-2rgqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x47 MACRO
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF01661
(Macro) 		5 LEU A 194
TRP A  95
ALA A 191
ALA A  98
GLY A 214
 None
 1.33A 4rn6A-2x47A:
undetectable		 4rn6A-2x47A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 HIS A  86
LEU A 118
ALA A 181
ALA A 250
GLY A 155
 None
 1.24A 4rn6A-2xrmA:
undetectable		 4rn6A-2xrmA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 HIS A  86
LEU A 118
ALA A 198
ALA A 250
GLY A 155
 None
 1.22A 4rn6A-2xrmA:
undetectable		 4rn6A-2xrmA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CAA3-TYPE CYTOCHROME
OXIDASE SUBUNIT IV
CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3)
no annotation 		5 LEU C  58
LEU A 724
ALA A 728
ALA A 647
GLY A 638
 None
 1.41A 4rn6A-2yevC:
undetectable		 4rn6A-2yevC:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		5 HIS A 153
LEU A 185
ALA A 274
ALA A 324
GLY A 236
 None
 1.26A 4rn6A-2z2zA:
undetectable		 4rn6A-2z2zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		5 LEU A  69
LEU A  45
ALA A  80
ALA A  51
GLY A 296
 None
 1.44A 4rn6A-2zbzA:
undetectable		 4rn6A-2zbzA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcx TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 LEU A 153
LEU A 209
ALA A 107
ALA A 171
GLY A 102
 None
 1.46A 4rn6A-2zcxA:
undetectable		 4rn6A-2zcxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 HIS A 180
LEU A 214
ALA A 278
ALA A 359
GLY A 249
 None
 1.36A 4rn6A-3afgA:
undetectable		 4rn6A-3afgA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		5 HIS A 180
LEU A 214
ALA A 292
ALA A 359
GLY A 249
 None
 1.36A 4rn6A-3afgA:
undetectable		 4rn6A-3afgA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		5 TYR A 165
LEU A 102
LEU A  51
ALA A  48
GLY A 295
 None
None
None
WO4  A 701 (-3.2A)
None
 1.26A 4rn6A-3cfxA:
undetectable		 4rn6A-3cfxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		5 TYR A 162
LEU A  99
LEU A  48
ALA A  45
GLY A 290
 None
None
None
WO4  A 701 (-3.0A)
None
 1.21A 4rn6A-3cfzA:
undetectable		 4rn6A-3cfzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		5 TYR A 164
LEU A  99
LEU A  43
ALA A  40
GLY A 287
 None
None
None
WO4  A 701 (-3.1A)
None
 1.26A 4rn6A-3cg1A:
undetectable		 4rn6A-3cg1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		5 TYR A 159
LEU A  94
LEU A  38
ALA A  35
GLY A 282
 None
None
None
WO4  A 701 (-2.9A)
None
 1.23A 4rn6A-3cg3A:
undetectable		 4rn6A-3cg3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cij UPF0100 PROTEIN
AF_0094

(Archaeoglobus
fulgidus) 		PF13531
(SBP_bac_11) 		5 TYR A 157
LEU A  94
LEU A  43
ALA A  40
GLY A 286
 None
None
None
WO4  A 400 (-3.3A)
None
 1.27A 4rn6A-3cijA:
undetectable		 4rn6A-3cijA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 TYR A 366
LEU A 356
LEU A 196
ALA A  95
GLY A 189
 None
 1.19A 4rn6A-3eoqA:
undetectable		 4rn6A-3eoqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7c PROTEIN OF UNKNOWN
FUNCTION (DUF416)

(Marinobacter
hydrocarbonoclasticus) 		PF04222
(DUF416) 		5 HIS A 113
LEU A  22
ALA A  20
ALA A 115
GLY A  15
 None
 1.11A 4rn6A-3f7cA:
undetectable		 4rn6A-3f7cA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		5 LEU A 213
TRP A 205
ALA A 260
ALA A 124
GLY A 211
 None
 1.34A 4rn6A-3fw6A:
undetectable		 4rn6A-3fw6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		5 TYR A 165
LEU A 102
LEU A  51
ALA A  48
GLY A 295
 None
None
None
MOO  A 500 (-3.2A)
None
 1.25A 4rn6A-3k6xA:
undetectable		 4rn6A-3k6xA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdr HK97 FAMILY PHAGE
PORTAL PROTEIN

(Corynebacterium
diphtheriae) 		PF04860
(Phage_portal) 		5 LEU A 136
LEU A 301
ALA A 304
ALA A 107
GLY A 114
 None
 1.31A 4rn6A-3kdrA:
undetectable		 4rn6A-3kdrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 350
LEU A 319
ALA A 321
ALA A 305
GLY A 300
 None
 1.47A 4rn6A-3kumA:
undetectable		 4rn6A-3kumA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 TYR A 268
LEU A 413
ALA A 243
ALA A 194
GLY A 353
 None
 1.40A 4rn6A-3kzuA:
undetectable		 4rn6A-3kzuA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		5 HIS A 408
LEU A 449
LEU A  51
ALA A  49
GLY A 437
 None
CL  A  23 ( 4.7A)
None
None
None
 1.20A 4rn6A-3m1uA:
undetectable		 4rn6A-3m1uA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 TYR A 207
TRP A 212
LEU A 160
ALA A 153
GLY A 119
 None
 1.40A 4rn6A-3m49A:
undetectable		 4rn6A-3m49A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oka GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-6)-PHOSPHAT
IDYLINOSITOL
MONOMANNOSIDE
MANNOSYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 LEU A 247
LEU A 334
ALA A 277
ALA A 219
GLY A 212
 None
 1.22A 4rn6A-3okaA:
undetectable		 4rn6A-3okaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 LEU A 163
LEU A 498
ALA A 489
ALA A 476
GLY A 485
 None
 1.21A 4rn6A-3qp9A:
undetectable		 4rn6A-3qp9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 TYR A 309
LEU A  99
ALA A 101
ALA A 220
TRP A 105
 None
None
None
None
PO4  A 402 (-3.5A)
 1.36A 4rn6A-3qt4A:
undetectable		 4rn6A-3qt4A:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS B  57
TYR B  60
LEU B  99
TRP B 215
GLY B 216
 None
 0.54A 4rn6A-3r3gB:
36.4		 4rn6A-3r3gB:
97.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7k PROBABLE ACYL COA
DEHYDROGENASE

(Mycobacteroides
abscessus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 TYR A 169
LEU A 158
ALA A 156
ALA A 190
GLY A 200
 None
 1.14A 4rn6A-3r7kA:
undetectable		 4rn6A-3r7kA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sra ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		6 TRP A 116
LEU A 162
LEU A  31
ALA A  33
ALA A 132
GLY A  54
 None
 1.48A 4rn6A-3sraA:
undetectable		 4rn6A-3sraA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 TYR A 258
LEU A 400
ALA A 233
ALA A 185
GLY A 339
 None
 1.40A 4rn6A-3u0fA:
undetectable		 4rn6A-3u0fA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		5 HIS A 166
LEU A 168
LEU A 106
ALA A 109
GLY A 130
 None
 1.30A 4rn6A-3uykA:
undetectable		 4rn6A-3uykA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 TYR A1936
LEU A1781
ALA A1747
ALA A1727
GLY A1942
 None
 1.48A 4rn6A-3vkgA:
undetectable		 4rn6A-3vkgA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		5 TYR A 334
LEU A 320
ALA A 230
ALA A 255
GLY A 301
 None
 1.14A 4rn6A-3vszA:
undetectable		 4rn6A-3vszA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 HIS A 154
LEU A 186
ALA A 243
ALA A 311
GLY A 217
 None
 1.38A 4rn6A-3whiA:
undetectable		 4rn6A-3whiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 HIS A 154
LEU A 186
ALA A 259
ALA A 311
GLY A 217
 None
 1.21A 4rn6A-3whiA:
undetectable		 4rn6A-3whiA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuk D-LACTATE
DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 HIS A 204
LEU A 203
LEU A 163
ALA A 159
GLY A 148
 None
 1.42A 4rn6A-4cukA:
undetectable		 4rn6A-4cukA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du5 PFKB

(Polaromonas sp.
JS666) 		PF00294
(PfkB) 		5 LEU A 228
LEU A 170
ALA A 173
ALA A 207
GLY A 160
 None
 1.32A 4rn6A-4du5A:
undetectable		 4rn6A-4du5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqf PEX5-RELATED PROTEIN

(Mus musculus) 		PF13181
(TPR_8)
PF13432
(TPR_16) 		5 LEU A 203
TRP A 113
ALA A 106
ALA A  92
GLY A 172
 None
 1.17A 4rn6A-4eqfA:
undetectable		 4rn6A-4eqfA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1

(Saccharomyces
cerevisiae) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A 244
LEU A 163
ALA A 178
ALA A 236
GLY A 153
 None
 1.21A 4rn6A-4fgwA:
undetectable		 4rn6A-4fgwA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 TYR A 594
LEU A 596
LEU A 404
ALA A 560
GLY A 581
 TYR  A 594 (-1.3A)
LEU  A 596 ( 0.6A)
LEU  A 404 (-0.6A)
ALA  A 560 ( 0.0A)
GLY  A 581 ( 0.0A)
 1.50A 4rn6A-4flxA:
undetectable		 4rn6A-4flxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzl BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		5 TRP A 244
LEU A  80
LEU A 149
ALA A 147
GLY A 141
 None
 1.06A 4rn6A-4fzlA:
undetectable		 4rn6A-4fzlA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		5 TRP A 244
LEU A  80
LEU A 149
ALA A 147
GLY A 141
 None
 1.26A 4rn6A-4fznA:
undetectable		 4rn6A-4fznA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		5 LEU L 209
LEU M 381
ALA M 393
ALA L 174
GLY L 168
 None
 1.06A 4rn6A-4heaL:
undetectable		 4rn6A-4heaL:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkt INOSITOL
2-DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 TYR A 283
LEU A   7
ALA A  40
ALA A  18
GLY A  11
 None
 1.19A 4rn6A-4hktA:
undetectable		 4rn6A-4hktA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		5 TYR B 517
TRP B 480
LEU B 166
ALA B 169
GLY B 159
 None
 1.24A 4rn6A-4hstB:
undetectable		 4rn6A-4hstB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		5 LEU A 146
LEU A 108
ALA A 141
ALA A 105
GLY A 102
 None
 1.23A 4rn6A-4iheA:
undetectable		 4rn6A-4iheA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ius GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF00583
(Acetyltransf_1) 		5 TYR A 233
LEU A 222
ALA A 148
ALA A 207
GLY A 187
 None
 1.35A 4rn6A-4iusA:
undetectable		 4rn6A-4iusA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 TYR A 275
LEU A 421
ALA A 250
ALA A 201
GLY A 361
 None
 1.35A 4rn6A-4jgaA:
undetectable		 4rn6A-4jgaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		5 TYR A  22
LEU A 443
LEU A  92
ALA A  95
ALA A  30
 None
 1.35A 4rn6A-4jo0A:
undetectable		 4rn6A-4jo0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpz SODIUM CHANNEL
PROTEIN TYPE 2
SUBUNIT ALPHA

(Homo sapiens) 		PF00612
(IQ)
PF16905
(GPHH) 		5 TRP B1802
LEU B1825
LEU B1844
ALA B1841
ALA B1860
 None
 1.46A 4rn6A-4jpzB:
undetectable		 4rn6A-4jpzB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		5 LEU A 347
LEU A 178
ALA A 166
ALA A 276
GLY A 273
 None
 1.47A 4rn6A-4k22A:
undetectable		 4rn6A-4k22A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		5 LEU A 249
LEU A 155
ALA A 127
ALA A 201
GLY A 252
 None
 1.30A 4rn6A-4mlcA:
undetectable		 4rn6A-4mlcA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		5 LEU A 295
LEU A 219
ALA A 162
ALA A 151
GLY A 242
 None
 1.38A 4rn6A-4p98A:
undetectable		 4rn6A-4p98A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		5 TYR A 102
LEU A 246
LEU A  38
ALA A  57
GLY A  50
 PYR  A 402 (-4.4A)
PYR  A 402 ( 4.6A)
None
None
None
 1.47A 4rn6A-4petA:
undetectable		 4rn6A-4petA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 LEU A 244
LEU A 270
ALA A 234
ALA A 279
GLY A 231
 None
 1.42A 4rn6A-4q0mA:
undetectable		 4rn6A-4q0mA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1

(Saccharomyces
cerevisiae) 		PF02127
(Peptidase_M18) 		5 LEU A 448
LEU A 345
ALA A 440
ALA A 430
GLY A 442
 None
 1.30A 4rn6A-4r8fA:
undetectable		 4rn6A-4r8fA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 TYR A 152
LEU A 141
ALA A 139
ALA A 173
GLY A 188
 None
 1.26A 4rn6A-4x28A:
undetectable		 4rn6A-4x28A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5u L-ASPARAGINASE

(Pyrococcus
furiosus) 		no annotation 5 LEU B 244
LEU B 270
ALA B 234
ALA B 279
GLY B 231
 None
 1.47A 4rn6A-5b5uB:
undetectable		 4rn6A-5b5uB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		5 LEU A 247
LEU A 198
TRP A 232
ALA A 228
GLY A 234
 None
 1.50A 4rn6A-5bp8A:
undetectable		 4rn6A-5bp8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 TYR A  56
ALA A  17
ALA A  61
TRP A 312
GLY A 316
 None
 1.43A 4rn6A-5dz2A:
undetectable		 4rn6A-5dz2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		5 TYR A 640
TRP A 658
LEU A 627
ALA A 548
ALA A 577
 None
 1.18A 4rn6A-5gvbA:
undetectable		 4rn6A-5gvbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		5 TRP A  15
LEU A 133
LEU A 229
ALA A 235
GLY A 136
 None
 1.45A 4rn6A-5hj5A:
undetectable		 4rn6A-5hj5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk8 PROBABLE
PHEOPHORBIDASE

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 TYR A  64
LEU A 189
ALA A 107
ALA A  96
GLY A  90
 None
 1.20A 4rn6A-5hk8A:
undetectable		 4rn6A-5hk8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk8 PROBABLE
PHEOPHORBIDASE

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		5 TYR A  64
LEU A 189
LEU A  83
ALA A  96
GLY A  90
 None
 1.11A 4rn6A-5hk8A:
undetectable		 4rn6A-5hk8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		5 HIS A  96
TYR A  97
ALA A 136
ALA A 129
GLY A  59
 None
 1.26A 4rn6A-5hvmA:
undetectable		 4rn6A-5hvmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 HIS A 264
LEU A 292
LEU A 210
ALA A 220
ALA A 259
 None
 1.49A 4rn6A-5ie2A:
undetectable		 4rn6A-5ie2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbe INACTIVE
GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF02324
(Glyco_hydro_70) 		5 LEU A1272
LEU A1221
ALA A1224
ALA A1183
TRP A1348
 None
 1.49A 4rn6A-5jbeA:
undetectable		 4rn6A-5jbeA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd3 LAE5

(uncultured
bacterium) 		PF13472
(Lipase_GDSL_2) 		5 TYR A 138
LEU A  42
ALA A  44
ALA A 205
GLY A  37
 None
 1.38A 4rn6A-5jd3A:
undetectable		 4rn6A-5jd3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muw PACKAGING ENZYME P4

(Pseudomonas
virus phi6) 		PF11602
(NTPase_P4) 		5 HIS A 163
LEU A 145
ALA A 185
ALA A 161
TRP A 148
 None
 1.48A 4rn6A-5muwA:
undetectable		 4rn6A-5muwA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 5 HIS A 242
TYR A 244
TRP A 296
ALA A 173
GLY A  70
 None
 1.29A 4rn6A-5o82A:
undetectable		 4rn6A-5o82A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 5 TYR A 640
TRP A 658
LEU A 627
ALA A 548
ALA A 577
 None
 1.16A 4rn6A-5ogsA:
undetectable		 4rn6A-5ogsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		6 TYR A 138
LEU A 126
LEU A  56
ALA A 242
ALA A 177
GLY A 208
 None
 1.40A 4rn6A-5tr1A:
undetectable		 4rn6A-5tr1A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 5 TYR B 345
LEU B 170
LEU B 126
ALA B 380
GLY B 287
 None
 1.35A 4rn6A-5txrB:
undetectable		 4rn6A-5txrB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 TRP A 356
LEU A 165
TRP A 279
ALA A 244
GLY A 194
 None
PEG  A1206 ( 4.9A)
None
None
None
 1.29A 4rn6A-5u09A:
undetectable		 4rn6A-5u09A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 LEU A  34
LEU A 133
ALA A 129
ALA A 174
GLY A  99
 None
 1.44A 4rn6A-5u4hA:
undetectable		 4rn6A-5u4hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unl 3-KETOACYL-ACP
REDUCTASE

(Burkholderia
multivorans) 		PF13561
(adh_short_C2) 		5 HIS A  40
LEU A  16
ALA A  48
ALA A  63
GLY A  19
 None
 1.33A 4rn6A-5unlA:
undetectable		 4rn6A-5unlA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 TYR A 199
LEU A 172
LEU A  69
ALA A  24
GLY A  17
 None
 1.49A 4rn6A-5w4xA:
undetectable		 4rn6A-5w4xA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 5 TYR A 148
LEU A 154
ALA A 128
ALA A 121
GLY A 136
 None
 1.42A 4rn6A-5zb8A:
undetectable		 4rn6A-5zb8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eys -

(-) 		no annotation 5 TYR B 357
LEU B 361
LEU B 372
ALA B 253
GLY B 367
 None
 1.47A 4rn6A-6eysB:
undetectable		 4rn6A-6eysB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 5 LEU A 298
LEU A 283
ALA A 286
ALA A 275
GLY A 295
 None
 1.41A 4rn6A-6f74A:
undetectable		 4rn6A-6f74A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
13
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Mus musculus) 		no annotation 5 HIS H 304
LEU H 307
ALA Z  41
ALA H 178
GLY Z  45
 None
 1.36A 4rn6A-6g72H:
undetectable		 4rn6A-6g72H:
14.24