SIMILAR PATTERNS OF AMINO ACIDS FOR 4RMJ_A_NCAA402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 352
PHE A 214
LEU A 218
ILE A 330
 None
None
None
PHE  A 566 (-4.6A)
 0.63A 4rmjA-1amuA:
undetectable		 4rmjA-1amuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f02 INTIMIN

(Escherichia
coli) 		PF02368
(Big_2)
PF02369
(Big_1)
PF07979
(Intimin_C) 		4 LEU I 772
LEU I 784
ILE I 756
ASP I 757
 None
 0.83A 4rmjA-1f02I:
undetectable		 4rmjA-1f02I:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g65 PROTEASOME COMPONENT
PUP3

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 ILE I 125
PHE I 109
ILE I 119
ASP I 120
 None
 0.59A 4rmjA-1g65I:
undetectable		 4rmjA-1g65I:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 ILE A 100
LEU A 107
LEU A  67
ILE A  70
 None
 0.79A 4rmjA-1i0aA:
undetectable		 4rmjA-1i0aA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lk5 D-RIBOSE-5-PHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		PF06026
(Rib_5-P_isom_A) 		4 ILE A 208
LEU A 191
ASN A 198
ILE A 195
 None
 0.79A 4rmjA-1lk5A:
2.8		 4rmjA-1lk5A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 ILE A 432
LEU A 426
LEU A 381
ILE A 377
 None
 0.85A 4rmjA-1moxA:
undetectable		 4rmjA-1moxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 PHE A 266
LEU A 267
LEU A 284
ASP A 273
 None
 0.86A 4rmjA-1nntA:
undetectable		 4rmjA-1nntA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 125
LEU A   9
ASN A 100
ILE A  99
 None
 0.85A 4rmjA-1np7A:
undetectable		 4rmjA-1np7A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		4 ILE A 327
PHE A 402
ILE A 323
ASP A 324
 None
None
CA  A 430 (-4.3A)
None
 0.71A 4rmjA-1nw1A:
undetectable		 4rmjA-1nw1A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7l TRANSCRIPTIONAL
REGULATOR MODE

(Escherichia
coli) 		PF00126
(HTH_1)
PF03459
(TOBE) 		4 LEU A 203
LEU A 158
ASN A 252
ASP A 200
 None
 0.82A 4rmjA-1o7lA:
undetectable		 4rmjA-1o7lA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ILE A 218
LEU A 166
LEU A 225
ILE A 228
 None
 0.73A 4rmjA-1p43A:
undetectable		 4rmjA-1p43A:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		6 ILE A  41
PHE A  44
LEU A  51
ASN A 116
ILE A 117
ASP A 118
 None
OAD  A1001 (-3.5A)
None
None
OAD  A1001 ( 4.4A)
None
 0.48A 4rmjA-1q1aA:
34.5		 4rmjA-1q1aA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q1a HST2 PROTEIN

(Saccharomyces
cerevisiae) 		PF02146
(SIR2) 		4 LEU A  86
ASN A 116
ILE A 117
ASP A 118
 None
None
OAD  A1001 ( 4.4A)
None
 0.74A 4rmjA-1q1aA:
34.5		 4rmjA-1q1aA:
41.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A) 		PF00073
(Rhv) 		4 ILE 3 189
LEU 3 113
LEU 3  94
ILE 3  53
 None
 0.74A 4rmjA-1r1a3:
undetectable		 4rmjA-1r1a3:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE

(Escherichia
coli) 		PF02146
(SIR2) 		4 ILE A  57
ASN A 130
ILE A 131
ASP A 132
 None
 0.36A 4rmjA-1s5pA:
20.8		 4rmjA-1s5pA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 ILE A  32
ASN A 101
ILE A 102
ASP A 103
 1PE  A 504 ( 4.7A)
None
None
None
 0.31A 4rmjA-1s7gA:
23.9		 4rmjA-1s7gA:
31.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		4 ILE A 102
LEU A  67
LEU A  48
ILE A  41
 None
 0.84A 4rmjA-1sa3A:
undetectable		 4rmjA-1sa3A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 PHE C 759
LEU C 762
LEU C 735
ILE C 739
 None
 0.86A 4rmjA-1u6gC:
undetectable		 4rmjA-1u6gC:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01547
(SBP_bac_1) 		4 LEU A 372
LEU A 207
ASN A 392
ILE A 393
 None
 0.81A 4rmjA-1urdA:
undetectable		 4rmjA-1urdA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wri FERREDOXIN II

(Equisetum
arvense) 		PF00111
(Fer2) 		4 ILE A  85
PHE A  15
LEU A  33
ILE A  24
 None
 0.77A 4rmjA-1wriA:
undetectable		 4rmjA-1wriA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		4 ILE A 263
PHE A  90
LEU A  89
ILE A 256
 None
 0.72A 4rmjA-1z7aA:
undetectable		 4rmjA-1z7aA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6o ISHP608 TRANSPOSASE

(Helicobacter
pylori) 		PF01797
(Y1_Tnp) 		4 ILE A  91
LEU A 106
LEU A  40
ILE A  44
 None
 0.78A 4rmjA-2a6oA:
undetectable		 4rmjA-2a6oA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MAJOR PLASMODIAL
MYOSIN HEAVY CHAIN
MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum;
Physarum
polycephalum) 		PF00612
(IQ)
PF13833
(EF-hand_8) 		4 PHE C  97
LEU C 117
ASN A 816
ILE A 817
 None
 0.71A 4rmjA-2bl0C:
undetectable		 4rmjA-2bl0C:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hd3 ETHANOLAMINE
UTILIZATION PROTEIN
EUTN

(Escherichia
coli) 		PF03319
(EutN_CcmL) 		4 ILE A  44
LEU A  57
LEU A  25
ASN A  46
 None
 0.83A 4rmjA-2hd3A:
undetectable		 4rmjA-2hd3A:
14.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hjh NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 ILE A 271
PHE A 274
ASN A 345
ILE A 346
ASP A 347
 NCA  A 900 (-4.6A)
NCA  A 900 ( 3.9A)
None
NCA  A 900 (-4.6A)
None
 0.28A 4rmjA-2hjhA:
31.5		 4rmjA-2hjhA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk7 SHIKIMATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ILE A 118
PHE A 110
LEU A 111
ILE A 126
 None
 0.79A 4rmjA-2hk7A:
6.4		 4rmjA-2hk7A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 584
LEU A 774
ASN A 566
ILE A 565
 None
 0.68A 4rmjA-2hnhA:
undetectable		 4rmjA-2hnhA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ILE A 189
PHE A 154
LEU A  85
LEU A 126
 None
 0.74A 4rmjA-2nztA:
undetectable		 4rmjA-2nztA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		4 ILE A 125
LEU A  71
LEU A  87
ILE A  78
 None
 0.86A 4rmjA-2qvlA:
2.7		 4rmjA-2qvlA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 LEU A 340
LEU A 304
ILE A 352
ASP A 351
 None
MTY  A 300 ( 3.9A)
None
None
 0.86A 4rmjA-2tohA:
undetectable		 4rmjA-2tohA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT

(Homo sapiens) 		PF11566
(PI31_Prot_N) 		4 ILE A  15
LEU A   7
ASN A  59
ASP A  20
 None
None
None
CSO  A  17 ( 3.6A)
 0.87A 4rmjA-2vt8A:
undetectable		 4rmjA-2vt8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7i MEVALONATE KINASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A 230
LEU A 277
LEU A  15
ILE A 219
 None
 0.82A 4rmjA-2x7iA:
undetectable		 4rmjA-2x7iA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ILE A  76
LEU A  72
LEU A 163
ILE A 229
 HEM  A1400 (-4.1A)
None
PG4  A1399 (-4.8A)
PG4  A1399 ( 4.5A)
 0.79A 4rmjA-2xkrA:
undetectable		 4rmjA-2xkrA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		4 ILE A 263
PHE A  90
LEU A  89
ILE A 256
 None
 0.70A 4rmjA-3cl6A:
undetectable		 4rmjA-3cl6A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin) 		4 LEU A 274
LEU A 247
ASN A 266
ILE A 265
 None
 0.79A 4rmjA-3ed3A:
undetectable		 4rmjA-3ed3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		4 ILE A  25
PHE A  48
LEU A  97
ILE A  93
 None
 0.87A 4rmjA-3fd2A:
undetectable		 4rmjA-3fd2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		4 ILE A 228
PHE A 251
LEU A 300
ILE A 296
 None
 0.87A 4rmjA-3fd2A:
undetectable		 4rmjA-3fd2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		4 LEU A 173
LEU A 236
ASN A 239
ILE A 238
 None
None
MN  A 502 ( 2.6A)
None
 0.74A 4rmjA-3gg0A:
undetectable		 4rmjA-3gg0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		4 ILE A  81
LEU A 107
LEU A 151
ILE A 127
 SO4  A 251 ( 4.4A)
EDO  A 262 (-4.7A)
None
None
 0.80A 4rmjA-3ggdA:
4.4		 4rmjA-3ggdA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3giu PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Staphylococcus
aureus) 		PF01470
(Peptidase_C15) 		4 ILE A  35
LEU A 191
LEU A  64
ILE A 198
 None
 0.82A 4rmjA-3giuA:
undetectable		 4rmjA-3giuA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ILE A 201
ASN A 157
ILE A 158
ASP A 159
 None
 0.74A 4rmjA-3gwjA:
undetectable		 4rmjA-3gwjA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjp PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG (BCP-4)

(Sulfolobus
solfataricus) 		PF00578
(AhpC-TSA) 		4 ILE A  67
PHE A  36
LEU A  13
ILE A  11
 None
 0.84A 4rmjA-3hjpA:
undetectable		 4rmjA-3hjpA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hnq VIRULENCE PROTEIN
STM3117

(Salmonella
enterica) 		PF00903
(Glyoxalase) 		4 PHE A  61
LEU A  27
ILE A  24
ASP A  25
 None
 0.79A 4rmjA-3hnqA:
undetectable		 4rmjA-3hnqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpe CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF04264
(YceI) 		4 LEU A 116
ASN A 152
ILE A 151
ASP A 155
 None
 0.83A 4rmjA-3hpeA:
undetectable		 4rmjA-3hpeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig0 DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ILE A 527
LEU A 563
LEU A 545
ILE A 556
 ILE  A 527 ( 0.6A)
LEU  A 563 ( 0.6A)
LEU  A 545 ( 0.6A)
ILE  A 556 ( 0.6A)
 0.87A 4rmjA-3ig0A:
undetectable		 4rmjA-3ig0A:
23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		4 ILE A  30
ASN A  99
ILE A 100
ASP A 101
 None
 0.49A 4rmjA-3jr3A:
25.5		 4rmjA-3jr3A:
34.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw3 ALANINE RACEMASE

(Bartonella
henselae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 345
LEU A  53
ILE A  26
ASP A  22
 None
 0.79A 4rmjA-3kw3A:
undetectable		 4rmjA-3kw3A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mip MSO-8G

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 ILE A  25
PHE A  48
LEU A  97
ILE A  93
 None
 0.82A 4rmjA-3mipA:
undetectable		 4rmjA-3mipA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 ILE A 432
LEU A 426
LEU A 381
ILE A 377
 None
 0.86A 4rmjA-3njpA:
undetectable		 4rmjA-3njpA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obi FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Rhodopseudomonas
palustris) 		PF00551
(Formyl_trans_N) 		4 LEU A  93
LEU A 267
ASN A 192
ILE A 191
 None
 0.88A 4rmjA-3obiA:
4.1		 4rmjA-3obiA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3od1 ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Bacillus
halodurans) 		PF13393
(tRNA-synt_His) 		4 ILE A 234
LEU A 217
LEU A 172
ASP A 174
 None
 0.88A 4rmjA-3od1A:
undetectable		 4rmjA-3od1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 ILE A 184
LEU A 213
LEU A 127
ILE A 172
 None
None
None
GOL  A2006 (-3.9A)
 0.86A 4rmjA-3okyA:
undetectable		 4rmjA-3okyA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 LEU A 289
LEU A 336
ILE A 339
ASP A 338
 None
 0.87A 4rmjA-3p27A:
2.1		 4rmjA-3p27A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A  59
PHE A  62
ASN A 112
ASP A 114
 None
A2N  A1000 (-3.8A)
None
None
 0.33A 4rmjA-3pkjA:
19.5		 4rmjA-3pkjA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 LEU A 259
LEU A 248
ILE A 162
ASP A 161
 None
 0.74A 4rmjA-3pkoA:
undetectable		 4rmjA-3pkoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py9 PROTEIN KINASE

(Staphylococcus
aureus) 		PF03793
(PASTA) 		4 LEU A  97
ASN A 132
ILE A 133
ASP A  99
 None
EU  A 305 (-3.6A)
None
EU  A 305 (-2.7A)
 0.63A 4rmjA-3py9A:
undetectable		 4rmjA-3py9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnb OXACILLINASE

(Escherichia
coli) 		PF00905
(Transpeptidase) 		4 ILE A 123
LEU A  78
LEU A 108
ILE A 112
 None
 0.85A 4rmjA-3qnbA:
undetectable		 4rmjA-3qnbA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE

(Ralstonia
pickettii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A   6
LEU A  90
ILE A  93
ASP A  92
 None
 0.83A 4rmjA-3rr1A:
undetectable		 4rmjA-3rr1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ILE A  79
LEU A  40
LEU A  27
ILE A  21
 None
 0.83A 4rmjA-3s8dA:
2.8		 4rmjA-3s8dA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		4 LEU A 380
LEU A  67
ILE A  84
ASP A  83
 None
 0.82A 4rmjA-3s9jA:
undetectable		 4rmjA-3s9jA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1s AUTOPHAGY PROTEIN 5

(Saccharomyces
cerevisiae) 		PF04106
(APG5) 		4 ILE A 220
LEU A 277
LEU A 229
ILE A 236
 None
 0.79A 4rmjA-3w1sA:
undetectable		 4rmjA-3w1sA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 ILE A  42
LEU A 278
ILE A 247
ASP A 248
 None
 0.79A 4rmjA-3wbkA:
2.7		 4rmjA-3wbkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A  59
PHE A  62
ASN A 112
ASP A 114
 None
APR  A1296 (-3.6A)
None
None
 0.30A 4rmjA-3zg6A:
18.7		 4rmjA-3zg6A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ako SPORE COAT PROTEIN A

(Bacillus
subtilis) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A  88
LEU A 159
ILE A  84
ASP A  85
 None
 0.85A 4rmjA-4akoA:
undetectable		 4rmjA-4akoA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq9 ACETYLCHOLINE
RECEPTOR GAMMA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 ILE E 172
LEU E  36
LEU E 212
ILE E 214
 None
 0.70A 4rmjA-4aq9E:
undetectable		 4rmjA-4aq9E:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A 154
ASN A 229
ILE A 230
ASP A 231
 CNA  A1395 (-3.8A)
CNA  A1395 (-3.7A)
SR7  A1396 (-4.8A)
CNA  A1395 (-3.5A)
 0.37A 4rmjA-4bn5A:
32.6		 4rmjA-4bn5A:
49.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 ILE H 608
PHE H 556
LEU H 552
ILE H 636
 None
 0.84A 4rmjA-4c8qH:
undetectable		 4rmjA-4c8qH:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		4 ILE A  74
LEU A  90
LEU A 320
ILE A 323
 None
 0.79A 4rmjA-4dyoA:
undetectable		 4rmjA-4dyoA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eoz SPECKLE-TYPE POZ
PROTEIN

(Homo sapiens) 		PF00651
(BTB) 		4 PHE A 229
LEU A 218
LEU A 204
ASN A 239
 None
 0.85A 4rmjA-4eozA:
undetectable		 4rmjA-4eozA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iao NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2

(Saccharomyces
cerevisiae) 		PF02146
(SIR2)
PF04574
(DUF592) 		5 ILE A 271
PHE A 274
ASN A 345
ILE A 346
ASP A 347
 None
APR  A 602 (-3.5A)
None
None
None
 0.41A 4rmjA-4iaoA:
31.5		 4rmjA-4iaoA:
25.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.51A 4rmjA-4ig9A:
27.7		 4rmjA-4ig9A:
40.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 PHE A 198
LEU A 171
ILE A 182
ASP A 183
 None
 0.87A 4rmjA-4j5uA:
2.0		 4rmjA-4j5uA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		4 ILE A1356
LEU A1305
LEU A1338
ILE A1255
 None
 0.79A 4rmjA-4ll6A:
undetectable		 4rmjA-4ll6A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni6 PUTATIVE SURFACE
ANCHORED PROTEIN

(Clostridium
perfringens) 		no annotation 4 LEU A  48
LEU A   9
ILE A  43
ASP A  44
 None
 0.85A 4rmjA-4ni6A:
undetectable		 4rmjA-4ni6A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nvs PUTATIVE ENZYME,
GLYOXALASE FAMILY

(Clostridioides
difficile) 		PF12681
(Glyoxalase_2) 		4 ILE A  29
LEU A  26
ASN A  41
ILE A  42
 None
 0.86A 4rmjA-4nvsA:
undetectable		 4rmjA-4nvsA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ILE A 303
PHE A 336
LEU A 309
LEU A 295
 None
 0.84A 4rmjA-4om9A:
undetectable		 4rmjA-4om9A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 PHE B 259
LEU B 267
LEU B 233
ASP B 213
 None
 0.79A 4rmjA-4pswB:
undetectable		 4rmjA-4pswB:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A  93
ASN A 168
ILE A 169
ASP A 170
 None
 0.39A 4rmjA-4y6oA:
38.8		 4rmjA-4y6oA:
95.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z11 AURONE SYNTHASE

(Coreopsis
grandiflora) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
PF12143
(PPO1_KFDV) 		4 PHE A 472
LEU A 413
LEU A 493
ASP A 429
 None
 0.85A 4rmjA-4z11A:
undetectable		 4rmjA-4z11A:
18.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.51A 4rmjA-4zzhA:
27.0		 4rmjA-4zzhA:
36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 ILE A 518
PHE A 511
LEU A 596
ILE A 594
 None
None
None
G  C   2 ( 4.3A)
 0.79A 4rmjA-5amqA:
undetectable		 4rmjA-5amqA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		4 LEU A 138
LEU A  29
ASN A  19
ILE A  21
 None
None
SAH  A 301 (-3.7A)
None
 0.85A 4rmjA-5bp7A:
3.3		 4rmjA-5bp7A:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A 270
ASN A 346
ILE A 347
ASP A 348
 None
 0.32A 4rmjA-5btrA:
29.1		 4rmjA-5btrA:
32.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cq9 SECRETED EFFECTOR
PROTEIN SOPD2

(Salmonella
enterica) 		PF11047
(SopD) 		4 ILE A 119
PHE A  99
LEU A  87
LEU A  56
 None
 0.84A 4rmjA-5cq9A:
undetectable		 4rmjA-5cq9A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		4 ILE A 236
LEU A 373
LEU A 366
ILE A 336
 None
 0.85A 4rmjA-5d6aA:
undetectable		 4rmjA-5d6aA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A  93
ASN A 168
ILE A 169
ASP A 170
 None
 0.31A 4rmjA-5fyqA:
39.4		 4rmjA-5fyqA:
84.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A  93
PHE A  96
ASN A 168
ASP A 170
 None
 0.63A 4rmjA-5fyqA:
39.4		 4rmjA-5fyqA:
84.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE B1427
LEU B1432
LEU B1408
ILE B1411
 None
 0.87A 4rmjA-5hb4B:
undetectable		 4rmjA-5hb4B:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd0 AROMATIC
PRENYLTRANSFERASE

(Aspergillus
terreus) 		PF11991
(Trp_DMAT) 		4 LEU A 359
LEU A 308
ASN A 351
ILE A 350
 None
 0.86A 4rmjA-5kd0A:
undetectable		 4rmjA-5kd0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of3 DNA PRIMASE LARGE
SUBUNIT PRIL

(Sulfolobus
solfataricus) 		no annotation 4 ILE B 191
LEU B  72
ASN B  78
ILE B  76
 None
 0.81A 4rmjA-5of3B:
undetectable		 4rmjA-5of3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE

(Xenopus
tropicalis) 		no annotation 4 ILE A  70
LEU A  80
ASN A 143
ASP A 145
 None
 0.57A 4rmjA-5oj7A:
23.1		 4rmjA-5oj7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 4 ILE A  48
ASN A 125
ILE A 126
ASP A 127
 None
 0.27A 4rmjA-5ol0A:
33.9		 4rmjA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 262
LEU A  29
ASN A  38
ILE A  37
 None
 0.60A 4rmjA-5u2aA:
3.0		 4rmjA-5u2aA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00496
(SBP_bac_5) 		4 LEU A 354
ASN A 348
ILE A 347
ASP A 346
 None
 0.67A 4rmjA-5u4oA:
undetectable		 4rmjA-5u4oA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7f UGGT

(Thermomyces
dupontii) 		PF01501
(Glyco_transf_8) 		4 ILE A1399
PHE A1318
LEU A1279
ILE A1276
 None
 0.75A 4rmjA-5y7fA:
undetectable		 4rmjA-5y7fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b1z GLUTAMATE--TRNA
LIGASE

(Elizabethkingia
anophelis) 		PF00749
(tRNA-synt_1c) 		4 ILE A 207
LEU A 230
LEU A 193
ILE A  98
 None
 0.73A 4rmjA-6b1zA:
undetectable		 4rmjA-6b1zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 UNCHARACTERIZED
PROTEIN

(Thermobifida
fusca) 		no annotation 4 LEU I 199
LEU I 139
ILE I 190
ASP I 191
 None
 0.83A 4rmjA-6c66I:
undetectable		 4rmjA-6c66I:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE

(Campylobacter
jejuni) 		no annotation 4 ILE A 151
LEU A 178
ILE A 157
ASP A 156
 None
 0.84A 4rmjA-6cf8A:
undetectable		 4rmjA-6cf8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Danio rerio) 		no annotation 4 PHE A  66
ASN A 137
ILE A 138
ASP A 139
 BJW  A 303 (-3.6A)
None
BJW  A 303 (-3.9A)
None
 0.31A 4rmjA-6enxA:
25.3		 4rmjA-6enxA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6flk CEP120

(Homo sapiens) 		no annotation 5 ILE A 475
LEU A 505
LEU A 534
ASN A 473
ILE A 472
 None
 0.99A 4rmjA-6flkA:
undetectable		 4rmjA-6flkA:
undetectable