SIMILAR PATTERNS OF AMINO ACIDS FOR 4RJD_B_TFPB203_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1avs TROPONIN C

(Gallus gallus) 		PF13833
(EF-hand_8) 		4 PHE A  29
LEU A  42
MET A  81
MET A  82
 None
 0.66A 4rjdB-1avsA:
12.0		 4rjdB-1avsA:
46.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckr HEAT SHOCK SUBSTRATE
BINDING DOMAIN OF
HSC-70

(Rattus
norvegicus) 		PF00012
(HSP70) 		4 LEU A 397
MET A 515
ALA A 519
MET A 408
 None
 0.88A 4rjdB-1ckrA:
undetectable		 4rjdB-1ckrA:
17.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A  19
LEU A  32
MET A  51
MET A  71
 None
 0.74A 4rjdB-1ggzA:
13.4		 4rjdB-1ggzA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
MET A 109
MET A 124
ALA A 128
 None
 0.60A 4rjdB-1ggzA:
13.4		 4rjdB-1ggzA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oqp CALTRACTIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		5 PHE A 110
LEU A 123
MET A 142
ALA A 146
MET A 163
 None
 0.89A 4rjdB-1oqpA:
12.0		 4rjdB-1oqpA:
45.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1skx ORPHAN NUCLEAR
RECEPTOR PXR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 373
MET A 343
ALA A 345
MET A 155
 None
 1.02A 4rjdB-1skxA:
undetectable		 4rjdB-1skxA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		4 LEU A  83
MET A  74
MET A  86
ALA A  90
 None
CAO  A 429 (-4.5A)
None
None
 1.01A 4rjdB-1vgqA:
undetectable		 4rjdB-1vgqA:
7.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 LEU B 105
MET B 109
ALA B 128
MET B 144
MET B 145
 None
 1.03A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 LEU B 105
MET B 124
ALA B 128
MET B 144
MET B 145
 None
 0.74A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE B  92
LEU B 105
MET B 109
ALA B 128
MET B 144
 None
 0.99A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE B  92
LEU B 105
MET B 109
MET B 144
 None
 0.92A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE B  92
LEU B 105
MET B 124
ALA B 128
MET B 144
 None
 0.79A 4rjdB-1zotB:
12.8		 4rjdB-1zotB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		4 PHE A 209
LEU A 212
MET A  23
ALA A  21
 None
 1.00A 4rjdB-2bacA:
undetectable		 4rjdB-2bacA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF13833
(EF-hand_8) 		5 LEU C  40
MET C  59
ALA C  63
MET C  79
MET C  80
 None
 1.23A 4rjdB-2bl0C:
10.0		 4rjdB-2bl0C:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF13833
(EF-hand_8) 		5 PHE C  27
MET C  59
ALA C  63
MET C  79
MET C  80
 None
 1.08A 4rjdB-2bl0C:
10.0		 4rjdB-2bl0C:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d58 ALLOGRAFT
INFLAMMATORY FACTOR
1

(Homo sapiens) 		no annotation 4 PHE A  57
LEU A  70
MET A 109
MET A 110
 None
 0.90A 4rjdB-2d58A:
8.5		 4rjdB-2d58A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		4 LEU A 105
MET A 109
MET A 124
ALA A 128
 None
 0.87A 4rjdB-2f2pA:
11.8		 4rjdB-2f2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		4 PHE A  19
LEU A  32
MET A  51
MET A  72
 None
 0.89A 4rjdB-2f2pA:
11.8		 4rjdB-2f2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
ALA A 128
MET A 144
MET A 145
 None
 0.50A 4rjdB-2f2pA:
11.8		 4rjdB-2f2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
MET A 109
ALA A 128
MET A 145
 None
 0.66A 4rjdB-2f2pA:
11.8		 4rjdB-2f2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		4 PHE A 271
LEU A 147
MET A 273
ALA A 399
 None
 0.88A 4rjdB-2g29A:
undetectable		 4rjdB-2g29A:
9.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ggm CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 113
LEU A 126
MET A 145
ALA A 149
MET A 166
 None
 0.68A 4rjdB-2ggmA:
13.0		 4rjdB-2ggmA:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		4 LEU X  73
MET X  76
ALA X  12
MET X  28
 None
 0.95A 4rjdB-2h3gX:
undetectable		 4rjdB-2h3gX:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2

(Homo sapiens) 		no annotation 4 LEU B  72
MET B  76
MET B 111
MET B 112
 None
 0.83A 4rjdB-2jjzB:
7.8		 4rjdB-2jjzB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2

(Homo sapiens) 		no annotation 5 PHE B  59
LEU B  72
MET B  91
MET B 111
MET B 112
 None
 0.95A 4rjdB-2jjzB:
7.8		 4rjdB-2jjzB:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2k2i CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 LEU A 126
MET A 145
ALA A 149
MET A 166
 None
 0.85A 4rjdB-2k2iA:
10.5		 4rjdB-2k2iA:
51.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2k2i CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A 113
LEU A 126
ALA A 149
MET A 166
 None
 0.72A 4rjdB-2k2iA:
10.5		 4rjdB-2k2iA:
51.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kn2 CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  18
LEU A  31
MET A  35
ALA A  54
MET A  71
 None
 0.50A 4rjdB-2kn2A:
11.0		 4rjdB-2kn2A:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kn2 CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  18
LEU A  31
MET A  35
MET A  50
ALA A  54
 None
 0.95A 4rjdB-2kn2A:
11.0		 4rjdB-2kn2A:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
ALA A 128
MET A 144
MET A 145
 None
 0.80A 4rjdB-2l1wA:
10.3		 4rjdB-2l1wA:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
MET A 109
MET A 144
MET A 145
 None
 0.81A 4rjdB-2l1wA:
10.3		 4rjdB-2l1wA:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
MET A 124
ALA A 128
MET A 145
 None
 0.89A 4rjdB-2l1wA:
10.3		 4rjdB-2l1wA:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lmv CALMODULIN-RELATED
PROTEIN 97A

(Drosophila
melanogaster) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
MET A 109
MET A 124
ALA A 128
 None
 1.09A 4rjdB-2lmvA:
10.8		 4rjdB-2lmvA:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 LEU A 105
MET A 109
MET A 124
ALA A 128
MET A 144
 None
 1.28A 4rjdB-2n6aA:
10.6		 4rjdB-2n6aA:
98.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
MET A 124
ALA A 128
MET A 144
 None
 1.03A 4rjdB-2n6aA:
10.6		 4rjdB-2n6aA:
98.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n7l TROPONIN C/TROPONIN
I CHIMERA

(Homo sapiens) 		PF13833
(EF-hand_8) 		4 PHE C  27
LEU C  41
MET C  80
MET C  81
 None
4J4  C  84 ( 4.1A)
4J4  C  84 ( 4.1A)
4J4  C  84 ( 4.7A)
 0.87A 4rjdB-2n7lC:
8.4		 4rjdB-2n7lC:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obh CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 113
LEU A 126
MET A 145
ALA A 149
MET A 166
 None
 0.70A 4rjdB-2obhA:
13.1		 4rjdB-2obhA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ro9 CALMODULIN-2

(Glycine max) 		PF13499
(EF-hand_7) 		4 LEU A 105
MET A 109
ALA A 128
MET A 145
 None
 0.65A 4rjdB-2ro9A:
12.7		 4rjdB-2ro9A:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ro9 CALMODULIN-2

(Glycine max) 		PF13499
(EF-hand_7) 		4 PHE A  92
LEU A 105
MET A 109
ALA A 128
 None
 0.66A 4rjdB-2ro9A:
12.7		 4rjdB-2ro9A:
86.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		4 LEU A  12
ALA A  24
MET A  30
MET A  45
 None
 0.98A 4rjdB-2wl3A:
undetectable		 4rjdB-2wl3A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 LEU A 308
MET A 493
MET A 247
ALA A 299
MET A 251
 None
 1.39A 4rjdB-2zciA:
undetectable		 4rjdB-2zciA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoi PILM

(Escherichia
coli) 		PF07419
(PilM) 		4 LEU A  82
MET A  78
ALA A  18
MET A  25
 None
 1.03A 4rjdB-3eoiA:
undetectable		 4rjdB-3eoiA:
16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 322
LEU A 335
MET A 354
MET A 374
MET A 375
 None
 0.72A 4rjdB-3evrA:
11.1		 4rjdB-3evrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
LEU A 408
MET A 412
ALA A 431
MET A 447
 None
 1.08A 4rjdB-3evrA:
11.1		 4rjdB-3evrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
LEU A 408
MET A 412
ALA A 431
MET A 448
 None
 0.85A 4rjdB-3evrA:
11.1		 4rjdB-3evrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
LEU A 408
MET A 427
ALA A 431
MET A 447
 None
 1.00A 4rjdB-3evrA:
11.1		 4rjdB-3evrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
LEU A 408
MET A 427
ALA A 431
MET A 448
 None
 0.66A 4rjdB-3evrA:
11.1		 4rjdB-3evrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ifk CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		5 PHE A  19
LEU A  32
MET A  36
MET A  71
MET A  72
 None
 0.56A 4rjdB-3ifkA:
11.7		 4rjdB-3ifkA:
40.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ifk CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		5 PHE A  19
LEU A  32
MET A  51
MET A  71
MET A  72
 None
 0.43A 4rjdB-3ifkA:
11.7		 4rjdB-3ifkA:
40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Plasmodium
falciparum) 		PF13499
(EF-hand_7) 		5 PHE A 131
LEU A 144
MET A 168
MET A 188
MET A 189
 None
 0.71A 4rjdB-3k21A:
11.0		 4rjdB-3k21A:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kf9 CALTRACTIN

(Scherffelia
dubia) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE A  36
LEU A  49
MET A  53
MET A  88
MET A  89
 None
 0.76A 4rjdB-3kf9A:
12.7		 4rjdB-3kf9A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kf9 CALTRACTIN

(Scherffelia
dubia) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE A  36
LEU A  49
MET A  68
MET A  88
MET A  89
 None
 0.72A 4rjdB-3kf9A:
12.7		 4rjdB-3kf9A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kf9 CALTRACTIN

(Scherffelia
dubia) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE A 109
LEU A 122
MET A 141
ALA A 145
MET A 162
 None
 0.59A 4rjdB-3kf9A:
12.7		 4rjdB-3kf9A:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnb N-ACETYLTRANSFERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00797
(Acetyltransf_2) 		4 PHE A  79
LEU A  80
ALA A 124
MET A  32
 None
 0.92A 4rjdB-3lnbA:
undetectable		 4rjdB-3lnbA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzb NICKEL-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 PHE A 407
LEU A 408
MET A 411
ALA A 301
 None
 0.97A 4rjdB-3mzbA:
undetectable		 4rjdB-3mzbA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4y CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Plasmodium
vivax) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 PHE A 134
LEU A 147
MET A 191
MET A 192
 None
 0.51A 4rjdB-3o4yA:
8.6		 4rjdB-3o4yA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ova CCA-ADDING ENZYME

(Archaeoglobus
fulgidus) 		PF01909
(NTP_transf_2)
PF09249
(tRNA_NucTransf2) 		4 PHE A 421
LEU A 420
MET A 432
MET A 433
 None
 1.02A 4rjdB-3ovaA:
undetectable		 4rjdB-3ovaA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 4 PHE A 387
LEU A   3
MET A  86
ALA A  30
 None
 1.01A 4rjdB-3oy2A:
undetectable		 4rjdB-3oy2A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PHE A 463
ALA A 497
MET A 513
MET A 514
 None
 0.87A 4rjdB-3q5iA:
8.3		 4rjdB-3q5iA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PHE A 463
LEU A 476
MET A 513
MET A 514
 None
 0.75A 4rjdB-3q5iA:
8.3		 4rjdB-3q5iA:
9.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qrx CENTRIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		5 PHE A  37
LEU A  50
MET A  69
MET A  89
MET A  90
 None
 0.76A 4rjdB-3qrxA:
12.7		 4rjdB-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qrx CENTRIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		4 PHE A 110
LEU A 123
MET A 142
ALA A 146
 None
 0.99A 4rjdB-3qrxA:
12.7		 4rjdB-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qrx CENTRIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		4 PHE A 110
MET A 142
ALA A 146
MET A 163
 None
 0.65A 4rjdB-3qrxA:
12.7		 4rjdB-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 313
LEU A 326
MET A 345
MET A 365
MET A 366
 None
 0.62A 4rjdB-3u0kA:
13.3		 4rjdB-3u0kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 386
LEU A 399
MET A 418
ALA A 422
 None
 0.48A 4rjdB-3u0kA:
13.3		 4rjdB-3u0kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqf D-THREO-3-HYDROXYASP
ARTATE DEHYDRATASE

(Delftia sp.
HT23) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 PHE A 129
LEU A 107
MET A  87
ALA A 114
 None
 1.04A 4rjdB-3wqfA:
undetectable		 4rjdB-3wqfA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a39 METALLO-CARBOXYPEPTI
DASE

(Pseudomonas
aeruginosa) 		PF00246
(Peptidase_M14) 		4 PHE A 107
ALA A  17
MET A   1
MET A  46
 None
 0.91A 4rjdB-4a39A:
undetectable		 4rjdB-4a39A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asl EPA1P

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 PHE A 141
LEU A 136
ALA A 100
MET A  63
 None
 1.02A 4rjdB-4aslA:
undetectable		 4rjdB-4aslA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fch OUTER MEMBRANE
PROTEIN SUSE

(Bacteroides
thetaiotaomicron) 		PF16411
(SusF_SusE) 		4 PHE A 304
LEU A 287
MET A 327
MET A 319
 None
 1.00A 4rjdB-4fchA:
undetectable		 4rjdB-4fchA:
20.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE D  19
LEU D  32
MET D  36
MET D  71
MET D  72
 PHE  D  19 ( 1.3A)
LEU  D  32 ( 0.6A)
MET  D  36 ( 0.0A)
MET  D  71 ( 0.0A)
MET  D  72 ( 0.0A)
 1.16A 4rjdB-4gowD:
12.6		 4rjdB-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE D  19
LEU D  32
MET D  51
MET D  71
MET D  72
 PHE  D  19 ( 1.3A)
LEU  D  32 ( 0.6A)
MET  D  51 ( 0.0A)
MET  D  71 ( 0.0A)
MET  D  72 ( 0.0A)
 0.67A 4rjdB-4gowD:
12.6		 4rjdB-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		7 PHE D  92
LEU D 105
MET D 109
MET D 124
ALA D 128
MET D 144
MET D 145
 PHE  D  92 ( 1.3A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ALA  D 128 ( 0.0A)
MET  D 144 ( 0.0A)
MET  D 145 ( 0.0A)
 0.93A 4rjdB-4gowD:
12.6		 4rjdB-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 322
LEU A 335
MET A 354
MET A 374
MET A 375
 None
 0.72A 4rjdB-4i2yA:
12.2		 4rjdB-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
LEU A 408
MET A 412
ALA A 431
MET A 448
 None
 0.76A 4rjdB-4i2yA:
12.2		 4rjdB-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
LEU A 408
MET A 427
ALA A 431
MET A 448
 None
 0.67A 4rjdB-4i2yA:
12.2		 4rjdB-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
MET A 412
ALA A 431
MET A 447
MET A 448
 None
 1.08A 4rjdB-4i2yA:
12.2		 4rjdB-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
MET A 427
ALA A 431
MET A 447
MET A 448
 None
 1.04A 4rjdB-4i2yA:
12.2		 4rjdB-4i2yA:
95.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwq CALCIUM-DEPENDENT
PROTEIN KINASE

(Plasmodium
berghei) 		PF13499
(EF-hand_7) 		4 LEU A 150
MET A 174
MET A 194
MET A 195
 None
 0.60A 4rjdB-4jwqA:
11.2		 4rjdB-4jwqA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwq CALCIUM-DEPENDENT
PROTEIN KINASE

(Plasmodium
berghei) 		PF13499
(EF-hand_7) 		4 PHE A 137
LEU A 150
MET A 194
MET A 195
 None
 0.71A 4rjdB-4jwqA:
11.2		 4rjdB-4jwqA:
17.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q57 CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  19
LEU A  32
MET A  36
MET A  71
MET A  72
 None
 1.06A 4rjdB-4q57A:
13.8		 4rjdB-4q57A:
46.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q57 CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  19
LEU A  32
MET A  51
MET A  71
MET A  72
 None
 0.68A 4rjdB-4q57A:
13.8		 4rjdB-4q57A:
46.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		4 PHE A 313
LEU A 306
MET A 240
ALA A 387
 None
 0.84A 4rjdB-4ug4A:
undetectable		 4rjdB-4ug4A:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 PHE A 120
LEU A 133
MET A 152
MET A 173
 None
 0.78A 4rjdB-4wpxA:
12.2		 4rjdB-4wpxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzc NUCLEOPROTEIN

(Nairobi sheep
disease
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 PHE A 331
LEU A 332
MET A 335
ALA A 315
 None
 1.03A 4rjdB-4xzcA:
undetectable		 4rjdB-4xzcA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymp INTERNALIN

(Bacillus
anthracis) 		PF05031
(NEAT) 		4 PHE A  56
LEU A  59
MET A 103
ALA A  48
 HEM  A 201 (-4.6A)
None
HEM  A 201 ( 3.8A)
None
 0.97A 4rjdB-4ympA:
undetectable		 4rjdB-4ympA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmu DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF)
PF01590
(GAF) 		4 PHE A 264
LEU A 256
ALA A 249
MET A 287
 None
 1.00A 4rjdB-4zmuA:
undetectable		 4rjdB-4zmuA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN

(Homo sapiens;
Staphylococcus
aureus) 		PF02216
(B)
PF13499
(EF-hand_7) 		4 PHE A1020
LEU A1033
MET A1052
MET A1072
 None
 0.76A 4rjdB-5cocA:
12.6		 4rjdB-5cocA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN

(Homo sapiens;
Staphylococcus
aureus) 		PF02216
(B)
PF13499
(EF-hand_7) 		4 PHE A1020
LEU A1033
MET A1052
MET A1072
 None
 1.03A 4rjdB-5cocA:
12.6		 4rjdB-5cocA:
27.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d43 CENTRIN-1

(Mus musculus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE A 113
LEU A 126
MET A 145
ALA A 149
MET A 166
 None
 0.61A 4rjdB-5d43A:
12.7		 4rjdB-5d43A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 PHE A 370
LEU A 373
ALA A 448
MET A 408
 None
 1.02A 4rjdB-5h7dA:
undetectable		 4rjdB-5h7dA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 PHE A 896
LEU A 946
MET A 905
MET A 944
 None
 0.93A 4rjdB-5hzrA:
undetectable		 4rjdB-5hzrA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 LEU A 652
MET A 648
ALA A 698
MET A 673
 None
 0.82A 4rjdB-5kd5A:
undetectable		 4rjdB-5kd5A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 4 LEU A 370
MET A 389
ALA A 393
MET A 410
 None
 1.00A 4rjdB-5ukgA:
11.9		 4rjdB-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 5 PHE A 284
LEU A 297
MET A 301
MET A 336
MET A 337
 None
 1.01A 4rjdB-5ukgA:
11.9		 4rjdB-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 4 PHE A 357
LEU A 370
ALA A 393
MET A 410
 None
 1.01A 4rjdB-5ukgA:
11.9		 4rjdB-5ukgA:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		4 PHE A  27
LEU A  41
MET A  60
MET A  81
 9XG  A 201 (-3.8A)
9XG  A 201 (-3.9A)
9XG  A 201 (-4.0A)
9XG  A 201 ( 4.6A)
 0.87A 4rjdB-5w88A:
7.8		 4rjdB-5w88A:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5

(Toxoplasma
gondii) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		4 PHE C 218
LEU C 222
ALA C 111
MET C  89
 None
 0.98A 4rjdB-5xxuC:
undetectable		 4rjdB-5xxuC:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 4 PHE A 443
LEU B  20
ALA A 449
MET A 431
 None
 0.92A 4rjdB-6c9mA:
undetectable		 4rjdB-6c9mA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d34 TERC

(Streptomyces) 		no annotation 4 PHE A  70
LEU A 125
MET A 123
MET A 171
 IPA  A 202 ( 4.4A)
IPA  A 202 ( 4.4A)
IPA  A 201 (-2.9A)
IPA  A 202 ( 4.1A)
 0.91A 4rjdB-6d34A:
undetectable		 4rjdB-6d34A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 4 PHE A  91
LEU A 385
MET A 396
ALA A 420
 None
 1.03A 4rjdB-6em0A:
undetectable		 4rjdB-6em0A:
22.35