SIMILAR PATTERNS OF AMINO ACIDS FOR 4RJD_A_TFPA203

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1avs TROPONIN C

(Gallus gallus) 		PF13833
(EF-hand_8) 		4 PHE A  29
ILE A  37
LEU A  42
MET A  81
 None
 0.50A 4rjdA-1avsA:
12.4		 4rjdA-1avsA:
46.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  19
ILE A  27
LEU A  32
MET A  51
VAL A  63
 None
None
None
None
CA  A 150 ( 4.9A)
 0.55A 4rjdA-1ggzA:
14.0		 4rjdA-1ggzA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
MET A 109
MET A 124
VAL A 136
 None
 0.42A 4rjdA-1ggzA:
14.0		 4rjdA-1ggzA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ggz CALMODULIN-RELATED
PROTEIN NB-1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  92
LEU A 105
MET A 124
ALA A 128
VAL A 136
 None
 0.33A 4rjdA-1ggzA:
14.0		 4rjdA-1ggzA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana) 		PF00161
(RIP) 		4 ILE A  63
LEU A  68
ALA A  24
VAL A  48
 None
 0.63A 4rjdA-1llnA:
undetectable		 4rjdA-1llnA:
18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oqp CALTRACTIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		5 PHE A 110
ILE A 118
LEU A 123
MET A 142
ALA A 146
 None
 0.64A 4rjdA-1oqpA:
12.4		 4rjdA-1oqpA:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qx2 VITAMIN D-DEPENDENT
CALCIUM-BINDING
PROTEIN, INTESTINAL

(Bos taurus) 		PF00036
(EF-hand_1) 		4 PHE A  13
ILE A  23
VAL A  61
MET A  69
 None
 0.54A 4rjdA-1qx2A:
7.7		 4rjdA-1qx2A:
45.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wrk TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES

(Homo sapiens) 		PF13833
(EF-hand_8) 		4 ILE A  36
LEU A  41
MET A  60
VAL A  72
 None
None
TFP  A 202 ( 4.0A)
None
 0.45A 4rjdA-1wrkA:
10.6		 4rjdA-1wrkA:
44.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 ILE B 100
LEU B 105
MET B 109
MET B 144
 None
 0.67A 4rjdA-1zotB:
13.0		 4rjdA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 ILE B 100
LEU B 105
MET B 109
VAL B 136
 None
None
None
CA  B 800 ( 4.9A)
 0.34A 4rjdA-1zotB:
13.0		 4rjdA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 ILE B 100
LEU B 105
MET B 124
ALA B 128
VAL B 136
 None
None
None
None
CA  B 800 ( 4.9A)
 0.36A 4rjdA-1zotB:
13.0		 4rjdA-1zotB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zot CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE B  92
ILE B 100
LEU B 105
MET B 124
VAL B 136
 None
None
None
None
CA  B 800 ( 4.9A)
 0.52A 4rjdA-1zotB:
13.0		 4rjdA-1zotB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccm CALEXCITIN

(Doryteuthis
pealeii) 		no annotation 4 ILE A  30
ALA A  73
VAL A  81
MET A  89
 None
 0.57A 4rjdA-2ccmA:
4.8		 4rjdA-2ccmA:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		4 ILE A 100
LEU A 105
MET A 109
MET A 124
 None
 0.71A 4rjdA-2f2pA:
13.2		 4rjdA-2f2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		4 PHE A  19
ILE A  27
LEU A  32
MET A  36
 None
 0.50A 4rjdA-2f2pA:
13.2		 4rjdA-2f2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		4 PHE A  19
ILE A  27
LEU A  32
MET A  51
 None
 0.35A 4rjdA-2f2pA:
13.2		 4rjdA-2f2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		6 PHE A  92
ILE A 100
LEU A 105
ALA A 128
VAL A 136
MET A 144
 None
None
None
None
CA  A1004 ( 4.9A)
None
 0.45A 4rjdA-2f2pA:
13.2		 4rjdA-2f2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f2p CALMODULIN FUSED
WITH
CALMODULIN-BINDING
DOMAIN OF
CALCINEURIN

(Bos taurus) 		PF13499
(EF-hand_7) 		6 PHE A  92
ILE A 100
LEU A 105
MET A 109
ALA A 128
VAL A 136
 None
None
None
None
None
CA  A1004 ( 4.9A)
 0.43A 4rjdA-2f2pA:
13.2		 4rjdA-2f2pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ggm CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 ILE A 121
LEU A 126
MET A 145
ALA A 149
VAL A 157
 None
 0.49A 4rjdA-2ggmA:
13.1		 4rjdA-2ggmA:
30.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ggm CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A 113
ILE A 121
LEU A 126
MET A 145
 None
 0.65A 4rjdA-2ggmA:
13.1		 4rjdA-2ggmA:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2

(Homo sapiens) 		no annotation 4 ILE B  67
LEU B  72
MET B  76
MET B 111
 None
 0.70A 4rjdA-2jjzB:
8.0		 4rjdA-2jjzB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjz IONIZED
CALCIUM-BINDING
ADAPTER MOLECULE 2

(Homo sapiens) 		no annotation 4 ILE B  67
LEU B  72
MET B  91
MET B 111
 None
 0.64A 4rjdA-2jjzB:
8.0		 4rjdA-2jjzB:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2k2i CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 ILE A 121
LEU A 126
MET A 145
ALA A 149
VAL A 157
 None
 0.68A 4rjdA-2k2iA:
10.6		 4rjdA-2k2iA:
51.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2k7d CALCIUM-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 ILE A 119
LEU A 124
VAL A 156
MET A 164
 None
 0.63A 4rjdA-2k7dA:
9.5		 4rjdA-2k7dA:
43.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kn2 CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 ILE A  26
LEU A  31
MET A  35
ALA A  54
VAL A  62
 None
None
None
None
CA  A 209 ( 4.5A)
 0.58A 4rjdA-2kn2A:
11.3		 4rjdA-2kn2A:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kn2 CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 ILE A  26
LEU A  31
MET A  35
MET A  50
VAL A  62
 None
None
None
None
CA  A 209 ( 4.5A)
 1.08A 4rjdA-2kn2A:
11.3		 4rjdA-2kn2A:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kn2 CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  18
ILE A  26
LEU A  31
ALA A  54
VAL A  62
 None
None
None
None
CA  A 209 ( 4.5A)
 0.37A 4rjdA-2kn2A:
11.3		 4rjdA-2kn2A:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2kn2 CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  18
ILE A  26
LEU A  31
MET A  50
VAL A  62
 None
None
None
None
CA  A 209 ( 4.5A)
 0.88A 4rjdA-2kn2A:
11.3		 4rjdA-2kn2A:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 ILE A 100
LEU A 105
ALA A 128
VAL A 136
MET A 144
 None
None
None
CA  A 234 ( 4.6A)
None
 0.72A 4rjdA-2l1wA:
10.5		 4rjdA-2l1wA:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 ILE A 100
LEU A 105
MET A 109
VAL A 136
MET A 144
 None
None
None
CA  A 234 ( 4.6A)
None
 0.71A 4rjdA-2l1wA:
10.5		 4rjdA-2l1wA:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  92
ILE A 100
LEU A 105
MET A 124
VAL A 136
 None
None
None
None
CA  A 234 ( 4.6A)
 0.66A 4rjdA-2l1wA:
10.5		 4rjdA-2l1wA:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1w CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		5 PHE A  92
ILE A 100
LEU A 105
VAL A 136
MET A 144
 None
None
None
CA  A 234 ( 4.6A)
None
 0.44A 4rjdA-2l1wA:
10.5		 4rjdA-2l1wA:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lmv CALMODULIN-RELATED
PROTEIN 97A

(Drosophila
melanogaster) 		PF13499
(EF-hand_7) 		5 PHE A  92
ILE A 100
LEU A 105
MET A 109
MET A 124
 None
 0.96A 4rjdA-2lmvA:
3.0		 4rjdA-2lmvA:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 ILE A 100
LEU A 105
MET A 109
ALA A 128
VAL A 136
 None
 0.82A 4rjdA-2n6aA:
10.9		 4rjdA-2n6aA:
98.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID

(Homo sapiens) 		PF13499
(EF-hand_7) 		6 PHE A  92
ILE A 100
LEU A 105
ALA A 128
VAL A 136
MET A 144
 None
 0.91A 4rjdA-2n6aA:
10.9		 4rjdA-2n6aA:
98.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2n6a HUMAN
CALMODULIN/CONNEXIN-
36 PEPTIDE HYBRID

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A  92
ILE A 100
LEU A 105
MET A 124
MET A 144
 None
 1.01A 4rjdA-2n6aA:
10.9		 4rjdA-2n6aA:
98.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obh CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 ILE A 121
LEU A 126
MET A 145
ALA A 149
VAL A 157
 None
None
None
None
CA  A1001 ( 4.9A)
 0.47A 4rjdA-2obhA:
13.3		 4rjdA-2obhA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2obh CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 113
ILE A 121
LEU A 126
MET A 145
VAL A 157
 None
None
None
None
CA  A1001 ( 4.9A)
 0.64A 4rjdA-2obhA:
13.3		 4rjdA-2obhA:
30.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ro9 CALMODULIN-2

(Glycine max) 		PF13499
(EF-hand_7) 		4 ILE A 100
LEU A 105
MET A 109
ALA A 128
 None
 0.43A 4rjdA-2ro9A:
13.0		 4rjdA-2ro9A:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ro9 CALMODULIN-2

(Glycine max) 		PF13499
(EF-hand_7) 		4 PHE A  92
ILE A 100
LEU A 105
ALA A 128
 None
 0.42A 4rjdA-2ro9A:
13.0		 4rjdA-2ro9A:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rob CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		4 ILE A 100
ALA A 128
VAL A 136
MET A 144
 None
 0.58A 4rjdA-2robA:
11.5		 4rjdA-2robA:
80.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rob CALMODULIN

(Glycine max) 		PF13499
(EF-hand_7) 		4 ILE A 100
LEU A 105
ALA A 128
VAL A 136
 None
 0.67A 4rjdA-2robA:
11.5		 4rjdA-2robA:
80.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sas SARCOPLASMIC
CALCIUM-BINDING
PROTEIN

(Branchiostoma
lanceolatum) 		PF13833
(EF-hand_8) 		5 ILE A  26
LEU A  18
ALA A  69
VAL A  77
MET A  85
 None
 1.38A 4rjdA-2sasA:
5.2		 4rjdA-2sasA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b32 CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		4 PHE A  19
ILE A  27
LEU A  32
MET A  51
 None
 0.43A 4rjdA-3b32A:
12.9		 4rjdA-3b32A:
46.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00565
(SNase)
PF00567
(TUDOR) 		4 PHE A 582
LEU A 496
ALA A 504
VAL A 571
 None
 0.66A 4rjdA-3bdlA:
undetectable		 4rjdA-3bdlA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE

(Neisseria
meningitidis) 		PF01225
(Mur_ligase)
PF08245
(Mur_ligase_M) 		4 ILE A  48
LEU A  46
ALA A  21
VAL A  28
 None
 0.70A 4rjdA-3eagA:
undetectable		 4rjdA-3eagA:
13.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 ILE A 403
LEU A 408
MET A 412
ALA A 431
VAL A 439
 None
 0.47A 4rjdA-3evrA:
13.1		 4rjdA-3evrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 322
ILE A 330
LEU A 335
MET A 354
 None
 0.42A 4rjdA-3evrA:
13.1		 4rjdA-3evrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 322
ILE A 330
LEU A 335
MET A 374
 None
 0.52A 4rjdA-3evrA:
13.1		 4rjdA-3evrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		6 PHE A 395
ILE A 403
LEU A 408
MET A 427
ALA A 431
VAL A 439
 None
 0.48A 4rjdA-3evrA:
13.1		 4rjdA-3evrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
MET A 427
ALA A 431
VAL A 439
MET A 447
 None
 0.96A 4rjdA-3evrA:
13.1		 4rjdA-3evrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwb CELL DIVISION
CONTROL PROTEIN 31

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7) 		4 PHE A 105
ILE A 113
LEU A 118
MET A 137
 None
 0.42A 4rjdA-3fwbA:
13.0		 4rjdA-3fwbA:
26.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ifk CALMODULIN

(Rattus
norvegicus) 		PF13499
(EF-hand_7) 		6 PHE A  19
ILE A  27
LEU A  32
MET A  36
MET A  51
MET A  71
 None
 0.56A 4rjdA-3ifkA:
11.8		 4rjdA-3ifkA:
40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k21 CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Plasmodium
falciparum) 		PF13499
(EF-hand_7) 		5 PHE A 131
ILE A 139
LEU A 144
MET A 168
MET A 188
 None
 0.71A 4rjdA-3k21A:
11.3		 4rjdA-3k21A:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kf9 CALTRACTIN

(Scherffelia
dubia) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 ILE A  44
LEU A  49
MET A  53
MET A  68
MET A  88
 None
 0.77A 4rjdA-3kf9A:
12.8		 4rjdA-3kf9A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kf9 CALTRACTIN

(Scherffelia
dubia) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE A  36
ILE A  44
LEU A  49
MET A  53
MET A  68
 None
 0.56A 4rjdA-3kf9A:
12.8		 4rjdA-3kf9A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kf9 CALTRACTIN

(Scherffelia
dubia) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		6 PHE A 109
ILE A 117
LEU A 122
MET A 141
ALA A 145
VAL A 153
 None
 0.55A 4rjdA-3kf9A:
12.8		 4rjdA-3kf9A:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khe CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF13499
(EF-hand_7) 		4 PHE A 132
ILE A 140
VAL A 174
MET A 182
 None
 0.50A 4rjdA-3kheA:
9.2		 4rjdA-3kheA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF13499
(EF-hand_7) 		4 ILE A 466
LEU A 471
VAL A 500
MET A 508
 None
 0.51A 4rjdA-3l19A:
8.1		 4rjdA-3l19A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF13499
(EF-hand_7) 		5 PHE A 458
ILE A 466
LEU A 471
MET A 488
VAL A 500
 None
 0.80A 4rjdA-3l19A:
8.1		 4rjdA-3l19A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ILE A 466
LEU A 471
MET A 488
VAL A 500
MET A 508
 None
 0.63A 4rjdA-3lijA:
8.9		 4rjdA-3lijA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PHE A 458
ILE A 466
VAL A 500
MET A 508
 None
 0.45A 4rjdA-3lijA:
8.9		 4rjdA-3lijA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4y CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Plasmodium
vivax) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 PHE A 134
ILE A 142
LEU A 147
MET A 191
 None
 0.45A 4rjdA-3o4yA:
8.8		 4rjdA-3o4yA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox5 CALCIUM-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A 111
ILE A 119
LEU A 124
MET A 128
 None
 0.53A 4rjdA-3ox5A:
11.5		 4rjdA-3ox5A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PHE A 463
ILE A 471
LEU A 476
MET A 513
 None
 0.68A 4rjdA-3q5iA:
8.4		 4rjdA-3q5iA:
9.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qrx CENTRIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		4 PHE A  37
ILE A  45
LEU A  50
MET A  54
 None
 0.54A 4rjdA-3qrxA:
12.9		 4rjdA-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qrx CENTRIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		5 PHE A  37
ILE A  45
LEU A  50
MET A  69
MET A  89
 None
 0.88A 4rjdA-3qrxA:
12.9		 4rjdA-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qrx CENTRIN

(Chlamydomonas
reinhardtii) 		PF13499
(EF-hand_7) 		5 PHE A 110
ILE A 118
LEU A 123
MET A 142
ALA A 146
 None
 0.75A 4rjdA-3qrxA:
12.9		 4rjdA-3qrxA:
52.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 ILE A 321
LEU A 326
MET A 345
MET A 365
 None
 0.51A 4rjdA-3u0kA:
13.7		 4rjdA-3u0kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 313
ILE A 321
LEU A 326
MET A 345
 None
 0.47A 4rjdA-3u0kA:
13.7		 4rjdA-3u0kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 386
ILE A 394
LEU A 399
MET A 403
VAL A 430
 None
 0.49A 4rjdA-3u0kA:
13.7		 4rjdA-3u0kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		6 PHE A 386
ILE A 394
LEU A 399
MET A 418
ALA A 422
VAL A 430
 None
 0.43A 4rjdA-3u0kA:
13.7		 4rjdA-3u0kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		7 ILE D 100
LEU D 105
MET D 109
MET D 124
ALA D 128
VAL D 136
MET D 144
 ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
MET  D 144 ( 0.0A)
 0.80A 4rjdA-4gowD:
12.6		 4rjdA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE D  19
ILE D  27
LEU D  32
MET D  51
 PHE  D  19 ( 1.3A)
ILE  D  27 ( 0.7A)
LEU  D  32 ( 0.6A)
MET  D  51 ( 0.0A)
 0.56A 4rjdA-4gowD:
12.6		 4rjdA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gow CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		7 PHE D  92
ILE D 100
LEU D 105
MET D 109
MET D 124
ALA D 128
VAL D 136
 PHE  D  92 ( 1.3A)
ILE  D 100 ( 0.7A)
LEU  D 105 ( 0.6A)
MET  D 109 ( 0.0A)
MET  D 124 ( 0.0A)
ALA  D 128 ( 0.0A)
VAL  D 136 ( 0.6A)
 0.65A 4rjdA-4gowD:
12.6		 4rjdA-4gowD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 322
ILE A 330
LEU A 335
MET A 354
MET A 374
 None
 0.72A 4rjdA-4i2yA:
11.9		 4rjdA-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
ILE A 403
LEU A 408
MET A 412
VAL A 439
 None
 0.41A 4rjdA-4i2yA:
11.9		 4rjdA-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		6 PHE A 395
ILE A 403
LEU A 408
MET A 427
ALA A 431
VAL A 439
 None
 0.48A 4rjdA-4i2yA:
11.9		 4rjdA-4i2yA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 395
MET A 427
ALA A 431
VAL A 439
MET A 447
 None
 0.95A 4rjdA-4i2yA:
11.9		 4rjdA-4i2yA:
95.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwq CALCIUM-DEPENDENT
PROTEIN KINASE

(Plasmodium
berghei) 		PF13499
(EF-hand_7) 		4 ILE A 145
LEU A 150
MET A 174
MET A 194
 None
 0.63A 4rjdA-4jwqA:
11.6		 4rjdA-4jwqA:
17.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A  67
ILE A  62
LEU A  31
MET A  35
MET A  50
 None
 0.92A 4rjdA-4oy4A:
5.3		 4rjdA-4oy4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q57 CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A  19
ILE A  27
LEU A  32
MET A  51
 None
 0.38A 4rjdA-4q57A:
13.8		 4rjdA-4q57A:
46.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q57 CALMODULIN

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A  19
ILE A  27
LEU A  32
MET A  71
 None
 0.47A 4rjdA-4q57A:
13.8		 4rjdA-4q57A:
46.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		5 PHE A 120
ILE A 128
LEU A 133
MET A 152
VAL A 164
 None
 0.63A 4rjdA-4wpxA:
12.1		 4rjdA-4wpxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PHE A 427
ILE A 435
LEU A 440
MET A 477
 None
 0.67A 4rjdA-4ysjA:
10.4		 4rjdA-4ysjA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 PHE A 427
ILE A 435
VAL A 469
MET A 477
 None
 0.30A 4rjdA-4ysjA:
10.4		 4rjdA-4ysjA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN

(Homo sapiens;
Staphylococcus
aureus) 		PF02216
(B)
PF13499
(EF-hand_7) 		4 PHE A1020
ILE A1028
LEU A1033
MET A1052
 None
 0.57A 4rjdA-5cocA:
12.7		 4rjdA-5cocA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN

(Homo sapiens;
Staphylococcus
aureus) 		PF02216
(B)
PF13499
(EF-hand_7) 		4 PHE A1020
ILE A1028
LEU A1033
MET A1072
 None
 0.70A 4rjdA-5cocA:
12.7		 4rjdA-5cocA:
27.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d43 CENTRIN-1

(Mus musculus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		6 PHE A 113
ILE A 121
LEU A 126
MET A 145
ALA A 149
VAL A 157
 None
None
None
None
None
CA  A1204 ( 4.9A)
 0.36A 4rjdA-5d43A:
12.9		 4rjdA-5d43A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		4 ILE A 240
LEU A 163
ALA A 519
VAL A 263
 None
 0.70A 4rjdA-5djsA:
undetectable		 4rjdA-5djsA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		4 ILE A 112
LEU A 117
MET A 121
MET A 136
 None
 0.68A 4rjdA-5i2qA:
9.7		 4rjdA-5i2qA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzs PUTATIVE CELL
SURFACE PROTEIN,
SIMILAR TO
INTERNALIN PROTEINS

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 PHE A  80
ILE A  85
LEU A  50
MET A  54
 None
 0.66A 4rjdA-5kzsA:
undetectable		 4rjdA-5kzsA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 5 ILE A 365
LEU A 370
MET A 389
ALA A 393
VAL A 401
 None
 0.69A 4rjdA-5ukgA:
11.7		 4rjdA-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 4 PHE A 284
ILE A 292
LEU A 297
MET A 301
 None
 0.63A 4rjdA-5ukgA:
11.7		 4rjdA-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 4 PHE A 284
ILE A 292
LEU A 297
MET A 316
 None
 0.51A 4rjdA-5ukgA:
11.7		 4rjdA-5ukgA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukg K-GECO

(Entacmaea
quadricolor) 		no annotation 5 PHE A 357
ILE A 365
LEU A 370
ALA A 393
VAL A 401
 None
 0.66A 4rjdA-5ukgA:
11.7		 4rjdA-5ukgA:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		4 ILE A  36
LEU A  41
MET A  45
VAL A  72
 9XG  A 201 ( 3.3A)
9XG  A 201 (-3.9A)
9XG  A 201 (-2.4A)
9XG  A 201 (-3.8A)
 0.64A 4rjdA-5w88A:
8.1		 4rjdA-5w88A:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		4 ILE A  36
LEU A  41
MET A  60
VAL A  72
 9XG  A 201 ( 3.3A)
9XG  A 201 (-3.9A)
9XG  A 201 (-4.0A)
9XG  A 201 (-3.8A)
 0.34A 4rjdA-5w88A:
8.1		 4rjdA-5w88A:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w88 TROPONIN C, TROPONIN
I

(Homo sapiens) 		PF00992
(Troponin)
PF13833
(EF-hand_8) 		4 PHE A  27
LEU A  41
MET A  60
VAL A  72
 9XG  A 201 (-3.8A)
9XG  A 201 (-3.9A)
9XG  A 201 (-4.0A)
9XG  A 201 (-3.8A)
 0.58A 4rjdA-5w88A:
8.1		 4rjdA-5w88A:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 4 ILE A 199
MET A 153
ALA A 151
VAL A 157
 None
 0.69A 4rjdA-5z5kA:
undetectable		 4rjdA-5z5kA:
18.18