SIMILAR PATTERNS OF AMINO ACIDS FOR 4RET_C_DGXC2005_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8p NADPH:FERREDOXIN
OXIDOREDUCTASE


(Azotobacter
vinelandii)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
4 ASN A 148
VAL A 144
THR A  18
ILE A  69
None
None
None
FAD  A 259 (-3.6A)
1.23A 4retC-1a8pA:
3.0
4retC-1a8pA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci3 PROTEIN (CYTOCHROME
F)


(Phormidium
laminosum)
PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N)
4 ASN M 173
VAL M 221
THR M 228
ILE M 214
None
1.50A 4retC-1ci3M:
undetectable
4retC-1ci3M:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes)
PF12354
(Internalin_N)
PF12799
(LRR_4)
4 ASN A 108
VAL A  91
THR A  56
ILE A  57
None
1.42A 4retC-1d0bA:
0.0
4retC-1d0bA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE


(Trichomonas
vaginalis)
PF01053
(Cys_Met_Meta_PP)
4 ASN A 185
VAL A 200
THR A 155
ILE A 164
None
1.50A 4retC-1e5fA:
2.1
4retC-1e5fA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekj BETA-CARBONIC
ANHYDRASE


(Pisum sativum)
PF00484
(Pro_CA)
4 ASN A 183
VAL A 217
THR A 199
ILE A 203
None
None
CL  A2007 (-4.1A)
None
1.31A 4retC-1ekjA:
undetectable
4retC-1ekjA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3m ESTROGEN
SULFOTRANSFERASE


(Homo sapiens)
PF00685
(Sulfotransfer_1)
4 ASN A 130
VAL A 136
THR A 260
ILE A 259
None
1.48A 4retC-1g3mA:
0.0
4retC-1g3mA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3


(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N)
4 ASN A 679
VAL A 124
THR A 178
ILE A 177
None
1.21A 4retC-1g8xA:
0.0
4retC-1g8xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE


(Hyphomicrobium
methylovorum)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 ASN A 210
VAL A 236
THR A 105
ILE A 108
None
1.40A 4retC-1gdhA:
3.0
4retC-1gdhA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae)
PF05203
(Hom_end_hint)
4 ASN A 448
VAL A 452
THR A   6
ILE A  18
None
1.47A 4retC-1gppA:
0.0
4retC-1gppA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A


(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
4 ASN A 690
VAL A 135
THR A 189
ILE A 188
None
0.99A 4retC-1jx2A:
2.5
4retC-1jx2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION


(Saccharomyces
cerevisiae)
PF03853
(YjeF_N)
4 ASN A  70
VAL A 137
THR A 176
ILE A 190
None
1.40A 4retC-1jztA:
3.2
4retC-1jztA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)


(Aquifex
aeolicus)
PF00072
(Response_reg)
PF00158
(Sigma54_activat)
4 ASN A 282
VAL A 287
THR A 279
ILE A 240
None
1.39A 4retC-1ny5A:
undetectable
4retC-1ny5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN


(Sulfolobus
solfataricus)
PF00005
(ABC_tran)
4 ASN K 245
VAL K 281
THR K 314
ILE K 313
None
1.33A 4retC-1oxxK:
undetectable
4retC-1oxxK:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus)
PF00028
(Cadherin)
4 ASN A 278
VAL A 302
THR A 245
ILE A 220
None
None
NAG  A 802 (-2.1A)
NAG  A 802 ( 4.8A)
1.46A 4retC-1q5aA:
undetectable
4retC-1q5aA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)


(Escherichia
coli)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1)
4 ASN A 465
VAL A 492
THR A 223
ILE A 246
TPQ  A 466 ( 3.3A)
None
None
None
1.26A 4retC-1qafA:
undetectable
4retC-1qafA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnh PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Plasmodium
falciparum)
PF00160
(Pro_isomerase)
4 ASN A  17
VAL A 145
THR A 166
ILE A 165
None
1.05A 4retC-1qnhA:
undetectable
4retC-1qnhA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Methanocaldococcus
jannaschii)
PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N)
4 ASN A 123
VAL A 279
THR A 121
ILE A 120
None
1.42A 4retC-1u9zA:
undetectable
4retC-1u9zA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
4 ASN A 216
VAL A 206
THR A 192
ILE A 173
None
1.47A 4retC-1vcwA:
undetectable
4retC-1vcwA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woc PRIMOSOMAL
REPLICATION PROTEIN
N


(Escherichia
coli)
PF00436
(SSB)
4 ASN A  59
VAL A  74
THR A  63
ILE A  66
None
1.13A 4retC-1wocA:
undetectable
4retC-1wocA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhl SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY MEMBER
(5L265), PUTATIVE
TROPINONE
REDUCTASE-II


(Caenorhabditis
elegans)
PF13561
(adh_short_C2)
4 ASN A  92
VAL A  67
THR A 130
ILE A  77
None
NDP  A1278 (-3.9A)
None
None
1.23A 4retC-1xhlA:
undetectable
4retC-1xhlA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A)
PF00680
(RdRP_1)
4 ASN A  71
VAL A 245
THR A 306
ILE A 303
None
1.21A 4retC-1xr6A:
undetectable
4retC-1xr6A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfo RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
ALPHA


(Mus musculus)
PF00102
(Y_phosphatase)
4 ASN A 422
VAL A 328
THR A 324
ILE A 319
None
1.47A 4retC-1yfoA:
2.0
4retC-1yfoA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yi7 BETA-XYLOSIDASE,
FAMILY 43 GLYCOSYL
HYDROLASE


(Clostridium
acetobutylicum)
PF04616
(Glyco_hydro_43)
4 ASN A 514
VAL A 396
THR A 420
ILE A 421
None
1.33A 4retC-1yi7A:
undetectable
4retC-1yi7A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A


(Homo sapiens)
PF00782
(DSPc)
4 ASN A 128
VAL A  55
THR A  97
ILE A  98
None
1.26A 4retC-1yz4A:
3.4
4retC-1yz4A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A


(Homo sapiens)
PF00782
(DSPc)
4 ASN A 128
VAL A  61
THR A  97
ILE A  98
None
1.37A 4retC-1yz4A:
3.4
4retC-1yz4A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE


(Burkholderia
cepacia)
PF00202
(Aminotran_3)
4 ASN A 394
VAL A 404
THR A 383
ILE A 382
None
1.23A 4retC-1z3zA:
undetectable
4retC-1z3zA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayu NUCLEOSOME ASSEMBLY
PROTEIN


(Saccharomyces
cerevisiae)
PF00956
(NAP)
4 ASN A 314
VAL A 283
THR A 202
ILE A 203
None
1.33A 4retC-2ayuA:
undetectable
4retC-2ayuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bht CYSTEINE SYNTHASE B

(Escherichia
coli)
PF00291
(PALP)
4 ASN A 270
VAL A 196
THR A 167
ILE A 166
None
1.27A 4retC-2bhtA:
2.1
4retC-2bhtA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE


(Pestivirus A)
PF00998
(RdRP_3)
4 ASN A 117
VAL A 104
THR A 391
ILE A 390
None
1.47A 4retC-2cjqA:
undetectable
4retC-2cjqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO


(Escherichia
coli)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 ASN A 487
VAL A 516
THR A 450
ILE A 447
CIT  A 701 (-3.5A)
None
None
None
1.43A 4retC-2fqdA:
undetectable
4retC-2fqdA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6z DUAL SPECIFICITY
PROTEIN PHOSPHATASE
5


(Homo sapiens)
PF00782
(DSPc)
4 ASN A 303
VAL A 230
THR A 272
ILE A 273
None
1.25A 4retC-2g6zA:
4.1
4retC-2g6zA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C


(Toxoplasma
gondii)
PF00481
(PP2C)
4 ASN A 297
VAL A 303
THR A 324
ILE A 269
None
1.34A 4retC-2i44A:
undetectable
4retC-2i44A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli)
PF01177
(Asp_Glu_race)
4 ASN A  93
VAL A 201
THR A 144
ILE A 148
GLU  A1287 (-4.0A)
None
None
None
1.37A 4retC-2jfnA:
2.3
4retC-2jfnA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyh POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 4


(Azotobacter
vinelandii)
PF12708
(Pectate_lyase_3)
4 ASN A 288
VAL A 252
THR A 261
ILE A 260
None
1.49A 4retC-2pyhA:
undetectable
4retC-2pyhA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3u PROTEASE DEGS

(Escherichia
coli)
PF13365
(Trypsin_2)
4 ASN A 216
VAL A 206
THR A 192
ILE A 173
None
1.48A 4retC-2r3uA:
undetectable
4retC-2r3uA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus)
PF00423
(HN)
4 ASN A 513
VAL A 525
THR A 455
ILE A 467
None
1.26A 4retC-2rkcA:
undetectable
4retC-2rkcA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE


(Lactococcus
lactis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 ASN A 141
VAL A   4
THR A 135
ILE A 162
ASN  A 141 ( 0.6A)
VAL  A   4 ( 0.6A)
THR  A 135 ( 0.8A)
ILE  A 162 ( 0.7A)
1.27A 4retC-2vbfA:
2.4
4retC-2vbfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3


(Homo sapiens)
PF00378
(ECH_1)
4 ASN A  58
VAL A  93
THR A 233
ILE A 236
None
1.46A 4retC-2vx2A:
undetectable
4retC-2vx2A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4g MYOSIN HEAVY CHAIN,
SKELETAL MUSCLE,
ADULT


(Gallus gallus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
4 ASN M 698
VAL M 124
THR M 178
ILE M 177
None
1.06A 4retC-2w4gM:
undetectable
4retC-2w4gM:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqw INTERNALIN B

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4)
4 ASN A 108
VAL A  91
THR A  56
ILE A  57
None
1.33A 4retC-2wqwA:
undetectable
4retC-2wqwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9q CYCLODIPEPTIDE
SYNTHETASE


(Mycobacterium
tuberculosis)
PF16715
(CDPS)
4 ASN A 251
VAL A 116
THR A 240
ILE A 243
None
1.43A 4retC-2x9qA:
4.0
4retC-2x9qA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2r NUCLEOSOME ASSEMBLY
PROTEIN


(Saccharomyces
cerevisiae)
PF00956
(NAP)
4 ASN A 314
VAL A 283
THR A 202
ILE A 203
None
1.37A 4retC-2z2rA:
2.1
4retC-2z2rA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium)
PF01370
(Epimerase)
4 ASN A 235
VAL A 115
THR A 129
ILE A 130
None
1.33A 4retC-3a1nA:
3.4
4retC-3a1nA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150


(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct)
PF00423
(HN)
PF06214
(SLAM)
4 ASN A 513
VAL A 525
THR A 455
ILE A 467
None
1.28A 4retC-3alxA:
undetectable
4retC-3alxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE


(Thermotoga
maritima)
PF01268
(FTHFS)
4 ASN A  71
VAL A 284
THR A 247
ILE A  64
None
1.47A 4retC-3do6A:
undetectable
4retC-3do6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eua PUTATIVE
FRUCTOSE-AMINOACID-6
-PHOSPHATE DEGLYCASE


(Bacillus
subtilis)
PF01380
(SIS)
4 ASN A 181
VAL A 301
THR A 273
ILE A 246
None
1.25A 4retC-3euaA:
5.8
4retC-3euaA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3


(Homo sapiens)
PF00782
(DSPc)
4 ASN A 163
VAL A   9
THR A 133
ILE A 136
None
1.34A 4retC-3f81A:
3.6
4retC-3f81A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Ruegeria
pomeroyi)
PF13458
(Peripla_BP_6)
4 ASN A 210
VAL A 223
THR A 199
ILE A 198
None
1.08A 4retC-3h5lA:
2.9
4retC-3h5lA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00171
(Aldedh)
4 ASN A 432
VAL A 257
THR A 266
ILE A 267
None
1.41A 4retC-3ju8A:
2.8
4retC-3ju8A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl0 GLUCURONOXYLANASE
XYNC


(Bacillus
subtilis)
PF17189
(Glyco_hydro_30C)
4 ASN A 289
VAL A 328
THR A 356
ILE A 355
None
0.98A 4retC-3kl0A:
undetectable
4retC-3kl0A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgi PROTEASE DEGS

(Escherichia
coli)
PF13365
(Trypsin_2)
4 ASN A 216
VAL A  58
THR A 169
ILE A 168
None
1.30A 4retC-3lgiA:
undetectable
4retC-3lgiA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgi PROTEASE DEGS

(Escherichia
coli)
PF13365
(Trypsin_2)
4 ASN A 216
VAL A 206
THR A 192
ILE A 173
None
1.47A 4retC-3lgiA:
undetectable
4retC-3lgiA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Clostridium
perfringens)
PF14010
(PEPcase_2)
4 ASN A  87
VAL A 122
THR A 127
ILE A 176
None
1.27A 4retC-3odmA:
undetectable
4retC-3odmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 ASN A  75
VAL A 466
THR A 474
ILE A 471
None
1.34A 4retC-3t6wA:
undetectable
4retC-3t6wA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE


(Coxiella
burnetii)
PF01041
(DegT_DnrJ_EryC1)
4 ASN A  83
VAL A 340
THR A 132
ILE A 284
None
1.42A 4retC-3uwcA:
undetectable
4retC-3uwcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB


(Pseudomonas
aeruginosa)
PF00873
(ACR_tran)
4 ASN A  83
VAL A  57
THR A  89
ILE A  90
None
1.45A 4retC-3w9iA:
undetectable
4retC-3w9iA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0t UNCHARACTERIZED
PROTEIN


(Vibrio
parahaemolyticus)
no annotation 4 ASN A  99
VAL A  17
THR A  52
ILE A  53
None
1.47A 4retC-3x0tA:
undetectable
4retC-3x0tA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asm BETA-AGARASE D

(Zobellia
galactanivorans)
no annotation 4 ASN B  57
VAL B  40
THR B 119
ILE B 118
None
0.80A 4retC-4asmB:
undetectable
4retC-4asmB:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
4 ASN A  14
VAL A  47
THR A  44
ILE A  43
None
0.94A 4retC-4c3oA:
undetectable
4retC-4c3oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus)
PF01650
(Peptidase_C13)
4 ASN A 201
VAL A 168
THR A 213
ILE A 191
None
1.24A 4retC-4d3yA:
2.5
4retC-4d3yA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A


(Homo sapiens)
PF01201
(Ribosomal_S8e)
4 ASN i 490
VAL i 271
THR i 284
ILE i 285
None
1.11A 4retC-4d61i:
undetectable
4retC-4d61i:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyv PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Serendipita
indica)
PF00160
(Pro_isomerase)
4 ASN A  16
VAL A 138
THR A 159
ILE A 158
None
0.92A 4retC-4eyvA:
undetectable
4retC-4eyvA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Enterococcus
gallinarum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A 324
VAL A 319
THR A 308
ILE A 312
None
1.42A 4retC-4hnlA:
undetectable
4retC-4hnlA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans)
PF00343
(Phosphorylase)
4 ASN A  67
VAL A 578
THR A 416
ILE A 415
None
0.93A 4retC-4l22A:
2.7
4retC-4l22A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Thermotoga
maritima)
PF00496
(SBP_bac_5)
4 ASN A 181
VAL A 163
THR A  53
ILE A  54
None
1.01A 4retC-4pfyA:
undetectable
4retC-4pfyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN


(Ruminiclostridium
thermocellum)
PF14262
(Cthe_2159)
4 ASN A  38
VAL A  53
THR A  72
ILE A  41
None
1.43A 4retC-4phbA:
undetectable
4retC-4phbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppy PUTATIVE
ACYLHYDROLASE


(Bacteroides
fragilis)
PF13472
(Lipase_GDSL_2)
4 ASN A  59
VAL A 212
THR A 151
ILE A 170
None
1.36A 4retC-4ppyA:
2.5
4retC-4ppyA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct)
PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ASN A  80
VAL A  63
THR A  28
ILE A  29
None
1.38A 4retC-4psjA:
undetectable
4retC-4psjA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT P


(Thermococcus
kodakarensis)
PF00562
(RNA_pol_Rpb2_6)
PF03604
(DNA_RNApol_7kD)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
4 ASN B  96
VAL B 690
THR B 857
ILE P  34
None
1.39A 4retC-4qiwB:
undetectable
4retC-4qiwB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ASN A  72
VAL A  55
THR A  20
ILE A  21
None
1.39A 4retC-4r5cA:
undetectable
4retC-4r5cA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ASN A  72
VAL A  55
THR A  20
ILE A  21
None
1.41A 4retC-4r5dA:
undetectable
4retC-4r5dA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I


(synthetic
construct)
PF12354
(Internalin_N)
PF13855
(LRR_8)
4 ASN A  72
VAL A  55
THR A  20
ILE A  21
None
1.40A 4retC-4r6fA:
undetectable
4retC-4r6fA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K


(synthetic
construct)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
4 ASN A  72
VAL A  55
THR A  20
ILE A  21
None
1.35A 4retC-4r6gA:
undetectable
4retC-4r6gA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp8 ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA


(Escherichia
coli)
PF03611
(EIIC-GAT)
4 ASN A 232
VAL A 327
THR A 284
ILE A 283
None
1.32A 4retC-4rp8A:
2.8
4retC-4rp8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uip REPEBODY (RAC1)

(Eptatretus
burgeri;
Listeria
monocytogenes;
synthetic
construct)
PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8)
4 ASN B  74
VAL B  57
THR B  22
ILE B  23
None
1.38A 4retC-4uipB:
undetectable
4retC-4uipB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB


(Burkholderia
cenocepacia)
PF00155
(Aminotran_1_2)
4 ASN A 242
VAL A 228
THR A  97
ILE A  95
None
1.21A 4retC-4wd2A:
undetectable
4retC-4wd2A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE


(Neurospora
crassa)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch)
4 ASN A 237
VAL A 257
THR A 269
ILE A 272
None
1.16A 4retC-4xgtA:
2.3
4retC-4xgtA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE


(Sulfurisphaera
tokodaii)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 ASN A 160
VAL A 296
THR A 274
ILE A 153
None
1.45A 4retC-4yzoA:
undetectable
4retC-4yzoA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE


(Sulfurisphaera
tokodaii)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 ASN A 160
VAL A 296
THR A 274
ILE A 275
None
1.38A 4retC-4yzoA:
undetectable
4retC-4yzoA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxz LEVOGLUCOSAN KINASE

(Lipomyces
starkeyi)
PF03702
(AnmK)
4 ASN A 332
VAL A 296
THR A 303
ILE A 302
None
0.99A 4retC-4zxzA:
undetectable
4retC-4zxzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP1
CAPSID PROTEIN VP3
CAPSID PROTEIN VP4


(Enterovirus D)
PF00073
(Rhv)
PF02226
(Pico_P1A)
4 ASN A  36
VAL D  66
THR C 164
ILE C 163
None
1.18A 4retC-5bnnA:
undetectable
4retC-5bnnA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
4 ASN A 286
VAL A 239
THR A 190
ILE A 199
None
1.28A 4retC-5c70A:
undetectable
4retC-5c70A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dpt PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY M MEMBER 1,
GAMMA-AMINOBUTYRIC
ACID
RECEPTOR-ASSOCIATED
PROTEIN-LIKE
1,GAMMA-AMINOBUTYRIC
ACID
RECEPTOR-ASSOCIATED
PROTEIN-LIKE 1


(Homo sapiens)
PF02991
(Atg8)
4 ASN A 105
VAL A  64
THR A  90
ILE A  91
None
1.37A 4retC-5dptA:
undetectable
4retC-5dptA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE


(Neurospora
crassa)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch)
4 ASN A 237
VAL A 257
THR A 269
ILE A 272
None
None
A  C   4 ( 4.7A)
None
1.23A 4retC-5e02A:
undetectable
4retC-5e02A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh5 LYSINE-SPECIFIC
DEMETHYLASE 2B


(Homo sapiens)
PF00646
(F-box)
4 ASN A1108
VAL A1155
THR A1134
ILE A1136
None
1.48A 4retC-5jh5A:
undetectable
4retC-5jh5A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF01437
(PSI)
PF01833
(TIG)
4 ASN A 686
VAL A 626
THR A 582
ILE A 583
None
1.44A 4retC-5lspA:
undetectable
4retC-5lspA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urb METHIONINE--TRNA
LIGASE


(Acinetobacter
baumannii)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g)
4 ASN A 327
VAL A 538
THR A 337
ILE A 339
None
1.47A 4retC-5urbA:
undetectable
4retC-5urbA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4t CADHERIN 23

(Danio rerio)
no annotation 4 ASN C   8
VAL C  93
THR C  28
ILE C  27
None
1.05A 4retC-5w4tC:
undetectable
4retC-5w4tC:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3


(Armillaria
tabescens)
no annotation 4 ASN A 208
VAL A 205
THR A 240
ILE A 241
None
1.19A 4retC-5yfbA:
undetectable
4retC-5yfbA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1


(Escherichia
coli;
Homo sapiens)
no annotation 4 ASN A1298
VAL A1225
THR A1267
ILE A1268
None
1.23A 4retC-6apxA:
4.5
4retC-6apxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4


(Homo sapiens)
no annotation 4 ASN A 196
VAL A 216
THR A 228
ILE A 231
None
1.10A 4retC-6c90A:
2.0
4retC-6c90A:
9.11