SIMILAR PATTERNS OF AMINO ACIDS FOR 4RET_A_DGXA1107_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a8p | NADPH:FERREDOXINOXIDOREDUCTASE (Azotobactervinelandii) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 4 | ASN A 148VAL A 144THR A 18ILE A 69 | NoneNoneNoneFAD A 259 (-3.6A) | 1.23A | 4retA-1a8pA:3.4 | 4retA-1a8pA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ci3 | PROTEIN (CYTOCHROMEF) (Phormidiumlaminosum) |
PF01333(Apocytochr_F_C)PF16639(Apocytochr_F_N) | 4 | ASN M 173VAL M 221THR M 228ILE M 214 | None | 1.50A | 4retA-1ci3M:0.0 | 4retA-1ci3M:13.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d0b | INTERNALIN B (Listeriamonocytogenes) |
PF12354(Internalin_N)PF12799(LRR_4) | 4 | ASN A 108VAL A 91THR A 56ILE A 57 | None | 1.42A | 4retA-1d0bA:0.0 | 4retA-1d0bA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e5f | METHIONINEGAMMA-LYASE (Trichomonasvaginalis) |
PF01053(Cys_Met_Meta_PP) | 4 | ASN A 185VAL A 200THR A 155ILE A 164 | None | 1.50A | 4retA-1e5fA:0.0 | 4retA-1e5fA:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ekj | BETA-CARBONICANHYDRASE (Pisum sativum) |
PF00484(Pro_CA) | 4 | ASN A 183VAL A 217THR A 199ILE A 203 | NoneNone CL A2007 (-4.1A)None | 1.31A | 4retA-1ekjA:undetectable | 4retA-1ekjA:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g3m | ESTROGENSULFOTRANSFERASE (Homo sapiens) |
PF00685(Sulfotransfer_1) | 4 | ASN A 130VAL A 136THR A 260ILE A 259 | None | 1.48A | 4retA-1g3mA:0.0 | 4retA-1g3mA:14.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8x | MYOSIN II HEAVYCHAIN FUSED TOALPHA-ACTININ 3 (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF00435(Spectrin)PF02736(Myosin_N) | 4 | ASN A 679VAL A 124THR A 178ILE A 177 | None | 1.21A | 4retA-1g8xA:0.0 | 4retA-1g8xA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gdh | D-GLYCERATEDEHYDROGENASE (Hyphomicrobiummethylovorum) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | ASN A 210VAL A 236THR A 105ILE A 108 | None | 1.40A | 4retA-1gdhA:0.0 | 4retA-1gdhA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpp | ENDONUCLEASE PI-SCEI (Saccharomycescerevisiae) |
PF05203(Hom_end_hint) | 4 | ASN A 448VAL A 452THR A 6ILE A 18 | None | 1.47A | 4retA-1gppA:undetectable | 4retA-1gppA:12.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jx2 | MYOSIN-2 HEAVYCHAIN,DYNAMIN-A (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF02736(Myosin_N) | 4 | ASN A 690VAL A 135THR A 189ILE A 188 | None | 0.99A | 4retA-1jx2A:2.5 | 4retA-1jx2A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jzt | HYPOTHETICAL 27.5KDA PROTEIN INSPX19-GCR2INTERGENIC REGION (Saccharomycescerevisiae) |
PF03853(YjeF_N) | 4 | ASN A 70VAL A 137THR A 176ILE A 190 | None | 1.40A | 4retA-1jztA:3.3 | 4retA-1jztA:13.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ny5 | TRANSCRIPTIONALREGULATOR (NTRCFAMILY) (Aquifexaeolicus) |
PF00072(Response_reg)PF00158(Sigma54_activat) | 4 | ASN A 282VAL A 287THR A 279ILE A 240 | None | 1.39A | 4retA-1ny5A:3.5 | 4retA-1ny5A:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oxx | ABC TRANSPORTER, ATPBINDING PROTEIN (Sulfolobussolfataricus) |
PF00005(ABC_tran) | 4 | ASN K 245VAL K 281THR K 314ILE K 313 | None | 1.32A | 4retA-1oxxK:undetectable | 4retA-1oxxK:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5a | EP-CADHERIN (Mus musculus) |
PF00028(Cadherin) | 4 | ASN A 278VAL A 302THR A 245ILE A 220 | NoneNoneNAG A 802 (-2.1A)NAG A 802 ( 4.8A) | 1.44A | 4retA-1q5aA:undetectable | 4retA-1q5aA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qaf | PROTEIN (COPPERAMINE OXIDASE) (Escherichiacoli) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3)PF07833(Cu_amine_oxidN1) | 4 | ASN A 465VAL A 492THR A 223ILE A 246 | TPQ A 466 ( 3.3A)NoneNoneNone | 1.26A | 4retA-1qafA:undetectable | 4retA-1qafA:22.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qnh | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Plasmodiumfalciparum) |
PF00160(Pro_isomerase) | 4 | ASN A 17VAL A 145THR A 166ILE A 165 | None | 1.05A | 4retA-1qnhA:undetectable | 4retA-1qnhA:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u9z | RIBOSE-PHOSPHATEPYROPHOSPHOKINASE (Methanocaldococcusjannaschii) |
PF00156(Pribosyltran)PF13793(Pribosyltran_N) | 4 | ASN A 123VAL A 279THR A 121ILE A 120 | None | 1.42A | 4retA-1u9zA:undetectable | 4retA-1u9zA:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcw | PROTEASE DEGS (Escherichiacoli) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 4 | ASN A 216VAL A 206THR A 192ILE A 173 | None | 1.47A | 4retA-1vcwA:undetectable | 4retA-1vcwA:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1woc | PRIMOSOMALREPLICATION PROTEINN (Escherichiacoli) |
PF00436(SSB) | 4 | ASN A 59VAL A 74THR A 63ILE A 66 | None | 1.13A | 4retA-1wocA:undetectable | 4retA-1wocA:8.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xhl | SHORT-CHAINDEHYDROGENASE/REDUCTASE FAMILY MEMBER(5L265), PUTATIVETROPINONEREDUCTASE-II (Caenorhabditiselegans) |
PF13561(adh_short_C2) | 4 | ASN A 92VAL A 67THR A 130ILE A 77 | NoneNDP A1278 (-3.9A)NoneNone | 1.23A | 4retA-1xhlA:undetectable | 4retA-1xhlA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xr6 | GENOME POLYPROTEIN (Rhinovirus A) |
PF00680(RdRP_1) | 4 | ASN A 71VAL A 245THR A 306ILE A 303 | None | 1.21A | 4retA-1xr6A:undetectable | 4retA-1xr6A:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yfo | RECEPTOR PROTEINTYROSINE PHOSPHATASEALPHA (Mus musculus) |
PF00102(Y_phosphatase) | 4 | ASN A 422VAL A 328THR A 324ILE A 319 | None | 1.47A | 4retA-1yfoA:undetectable | 4retA-1yfoA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yi7 | BETA-XYLOSIDASE,FAMILY 43 GLYCOSYLHYDROLASE (Clostridiumacetobutylicum) |
PF04616(Glyco_hydro_43) | 4 | ASN A 514VAL A 396THR A 420ILE A 421 | None | 1.33A | 4retA-1yi7A:undetectable | 4retA-1yi7A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yz4 | DUAL SPECIFICITYPHOSPHATASE-LIKE 15ISOFORM A (Homo sapiens) |
PF00782(DSPc) | 4 | ASN A 128VAL A 55THR A 97ILE A 98 | None | 1.26A | 4retA-1yz4A:3.5 | 4retA-1yz4A:10.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yz4 | DUAL SPECIFICITYPHOSPHATASE-LIKE 15ISOFORM A (Homo sapiens) |
PF00782(DSPc) | 4 | ASN A 128VAL A 61THR A 97ILE A 98 | None | 1.37A | 4retA-1yz4A:3.5 | 4retA-1yz4A:10.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3z | DIALKYLGLYCINEDECARBOXYLASE (Burkholderiacepacia) |
PF00202(Aminotran_3) | 4 | ASN A 394VAL A 404THR A 383ILE A 382 | None | 1.23A | 4retA-1z3zA:undetectable | 4retA-1z3zA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ayu | NUCLEOSOME ASSEMBLYPROTEIN (Saccharomycescerevisiae) |
PF00956(NAP) | 4 | ASN A 314VAL A 283THR A 202ILE A 203 | None | 1.33A | 4retA-2ayuA:undetectable | 4retA-2ayuA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bht | CYSTEINE SYNTHASE B (Escherichiacoli) |
PF00291(PALP) | 4 | ASN A 270VAL A 196THR A 167ILE A 166 | None | 1.27A | 4retA-2bhtA:2.0 | 4retA-2bhtA:15.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cjq | RNA-DIRECTED RNAPOLYMERASE (Pestivirus A) |
PF00998(RdRP_3) | 4 | ASN A 117VAL A 104THR A 391ILE A 390 | None | 1.47A | 4retA-2cjqA:undetectable | 4retA-2cjqA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fqd | BLUE COPPER OXIDASECUEO (Escherichiacoli) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ASN A 487VAL A 516THR A 450ILE A 447 | CIT A 701 (-3.5A)NoneNoneNone | 1.43A | 4retA-2fqdA:undetectable | 4retA-2fqdA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g6z | DUAL SPECIFICITYPROTEIN PHOSPHATASE5 (Homo sapiens) |
PF00782(DSPc) | 4 | ASN A 303VAL A 230THR A 272ILE A 273 | None | 1.25A | 4retA-2g6zA:4.1 | 4retA-2g6zA:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i44 | SERINE-THREONINEPHOSPHATASE 2C (Toxoplasmagondii) |
PF00481(PP2C) | 4 | ASN A 297VAL A 303THR A 324ILE A 269 | None | 1.34A | 4retA-2i44A:undetectable | 4retA-2i44A:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jfn | GLUTAMATE RACEMASE (Escherichiacoli) |
PF01177(Asp_Glu_race) | 4 | ASN A 93VAL A 201THR A 144ILE A 148 | GLU A1287 (-4.0A)NoneNoneNone | 1.37A | 4retA-2jfnA:2.1 | 4retA-2jfnA:15.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyh | POLY(BETA-D-MANNURONATE) C5 EPIMERASE 4 (Azotobactervinelandii) |
PF12708(Pectate_lyase_3) | 4 | ASN A 288VAL A 252THR A 261ILE A 260 | None | 1.50A | 4retA-2pyhA:undetectable | 4retA-2pyhA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3u | PROTEASE DEGS (Escherichiacoli) |
PF13365(Trypsin_2) | 4 | ASN A 216VAL A 206THR A 192ILE A 173 | None | 1.48A | 4retA-2r3uA:undetectable | 4retA-2r3uA:12.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rkc | HEMAGGLUTININ (Measlesmorbillivirus) |
PF00423(HN) | 4 | ASN A 513VAL A 525THR A 455ILE A 467 | None | 1.26A | 4retA-2rkcA:undetectable | 4retA-2rkcA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vbf | BRANCHED-CHAINALPHA-KETOACIDDECARBOXYLASE (Lactococcuslactis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | ASN A 141VAL A 4THR A 135ILE A 162 | ASN A 141 ( 0.6A)VAL A 4 ( 0.6A)THR A 135 ( 0.8A)ILE A 162 ( 0.7A) | 1.27A | 4retA-2vbfA:3.2 | 4retA-2vbfA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vx2 | ENOYL-COA HYDRATASEDOMAIN-CONTAININGPROTEIN 3 (Homo sapiens) |
PF00378(ECH_1) | 4 | ASN A 58VAL A 93THR A 233ILE A 236 | None | 1.46A | 4retA-2vx2A:3.1 | 4retA-2vx2A:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4g | MYOSIN HEAVY CHAIN,SKELETAL MUSCLE,ADULT (Gallus gallus) |
PF00063(Myosin_head)PF02736(Myosin_N) | 4 | ASN M 698VAL M 124THR M 178ILE M 177 | None | 1.06A | 4retA-2w4gM:undetectable | 4retA-2w4gM:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqw | INTERNALIN B (Listeriamonocytogenes) |
PF08191(LRR_adjacent)PF12354(Internalin_N)PF12799(LRR_4) | 4 | ASN A 108VAL A 91THR A 56ILE A 57 | None | 1.33A | 4retA-2wqwA:undetectable | 4retA-2wqwA:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x9q | CYCLODIPEPTIDESYNTHETASE (Mycobacteriumtuberculosis) |
PF16715(CDPS) | 4 | ASN A 251VAL A 116THR A 240ILE A 243 | None | 1.43A | 4retA-2x9qA:3.6 | 4retA-2x9qA:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2r | NUCLEOSOME ASSEMBLYPROTEIN (Saccharomycescerevisiae) |
PF00956(NAP) | 4 | ASN A 314VAL A 283THR A 202ILE A 203 | None | 1.37A | 4retA-2z2rA:2.2 | 4retA-2z2rA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a1n | NDP-SUGAR EPIMERASE (Thermoplasmavolcanium) |
PF01370(Epimerase) | 4 | ASN A 235VAL A 115THR A 129ILE A 130 | None | 1.33A | 4retA-3a1nA:undetectable | 4retA-3a1nA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3alx | HEMAGGLUTININ,LINKER,CDW150 (Measlesmorbillivirus;Saguinusoedipus;syntheticconstruct) |
PF00423(HN)PF06214(SLAM) | 4 | ASN A 513VAL A 525THR A 455ILE A 467 | None | 1.28A | 4retA-3alxA:undetectable | 4retA-3alxA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3do6 | FORMATE--TETRAHYDROFOLATE LIGASE (Thermotogamaritima) |
PF01268(FTHFS) | 4 | ASN A 71VAL A 284THR A 247ILE A 64 | None | 1.47A | 4retA-3do6A:undetectable | 4retA-3do6A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eua | PUTATIVEFRUCTOSE-AMINOACID-6-PHOSPHATE DEGLYCASE (Bacillussubtilis) |
PF01380(SIS) | 4 | ASN A 181VAL A 301THR A 273ILE A 246 | None | 1.25A | 4retA-3euaA:6.5 | 4retA-3euaA:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f81 | DUAL SPECIFICITYPROTEIN PHOSPHATASE3 (Homo sapiens) |
PF00782(DSPc) | 4 | ASN A 163VAL A 9THR A 133ILE A 136 | None | 1.34A | 4retA-3f81A:3.6 | 4retA-3f81A:10.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5l | PUTATIVEBRANCHED-CHAIN AMINOACID ABC TRANSPORTER (Ruegeriapomeroyi) |
PF13458(Peripla_BP_6) | 4 | ASN A 210VAL A 223THR A 199ILE A 198 | None | 1.08A | 4retA-3h5lA:2.1 | 4retA-3h5lA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ju8 | SUCCINYLGLUTAMICSEMIALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00171(Aldedh) | 4 | ASN A 432VAL A 257THR A 266ILE A 267 | None | 1.41A | 4retA-3ju8A:2.7 | 4retA-3ju8A:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kl0 | GLUCURONOXYLANASEXYNC (Bacillussubtilis) |
PF17189(Glyco_hydro_30C) | 4 | ASN A 289VAL A 328THR A 356ILE A 355 | None | 0.98A | 4retA-3kl0A:undetectable | 4retA-3kl0A:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgi | PROTEASE DEGS (Escherichiacoli) |
PF13365(Trypsin_2) | 4 | ASN A 216VAL A 58THR A 169ILE A 168 | None | 1.30A | 4retA-3lgiA:undetectable | 4retA-3lgiA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgi | PROTEASE DEGS (Escherichiacoli) |
PF13365(Trypsin_2) | 4 | ASN A 216VAL A 206THR A 192ILE A 173 | None | 1.47A | 4retA-3lgiA:undetectable | 4retA-3lgiA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odm | PHOSPHOENOLPYRUVATECARBOXYLASE (Clostridiumperfringens) |
PF14010(PEPcase_2) | 4 | ASN A 87VAL A 122THR A 127ILE A 176 | None | 1.27A | 4retA-3odmA:undetectable | 4retA-3odmA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6w | LACCASE (Steccherinumochraceum) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | ASN A 75VAL A 466THR A 474ILE A 471 | None | 1.34A | 4retA-3t6wA:undetectable | 4retA-3t6wA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwc | NUCLEOTIDE-SUGARAMINOTRANSFERASE (Coxiellaburnetii) |
PF01041(DegT_DnrJ_EryC1) | 4 | ASN A 83VAL A 340THR A 132ILE A 284 | None | 1.42A | 4retA-3uwcA:undetectable | 4retA-3uwcA:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w9i | MULTIDRUG RESISTANCEPROTEIN MEXB (Pseudomonasaeruginosa) |
PF00873(ACR_tran) | 4 | ASN A 83VAL A 57THR A 89ILE A 90 | None | 1.45A | 4retA-3w9iA:2.4 | 4retA-3w9iA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x0t | UNCHARACTERIZEDPROTEIN (Vibrioparahaemolyticus) |
no annotation | 4 | ASN A 99VAL A 17THR A 52ILE A 53 | None | 1.47A | 4retA-3x0tA:undetectable | 4retA-3x0tA:7.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4asm | BETA-AGARASE D (Zobelliagalactanivorans) |
no annotation | 4 | ASN B 57VAL B 40THR B 119ILE B 118 | None | 0.80A | 4retA-4asmB:undetectable | 4retA-4asmB:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 4 | ASN A 14VAL A 47THR A 44ILE A 43 | None | 0.95A | 4retA-4c3oA:undetectable | 4retA-4c3oA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d3y | LEGUMAIN (Cricetulusgriseus) |
PF01650(Peptidase_C13) | 4 | ASN A 201VAL A 168THR A 213ILE A 191 | None | 1.24A | 4retA-4d3yA:2.4 | 4retA-4d3yA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d61 | EUKARYOTIC PEPTIDECHAIN RELEASE FACTORGTP-BINDING SUBUNITERF3A (Homo sapiens) |
PF01201(Ribosomal_S8e) | 4 | ASN i 490VAL i 271THR i 284ILE i 285 | None | 1.11A | 4retA-4d61i:undetectable | 4retA-4d61i:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eyv | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Serendipitaindica) |
PF00160(Pro_isomerase) | 4 | ASN A 16VAL A 138THR A 159ILE A 158 | None | 0.92A | 4retA-4eyvA:undetectable | 4retA-4eyvA:11.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnl | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME (Enterococcusgallinarum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASN A 324VAL A 319THR A 308ILE A 312 | None | 1.42A | 4retA-4hnlA:undetectable | 4retA-4hnlA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l22 | PHOSPHORYLASE (Streptococcusmutans) |
PF00343(Phosphorylase) | 4 | ASN A 67VAL A 578THR A 416ILE A 415 | None | 0.93A | 4retA-4l22A:4.0 | 4retA-4l22A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pfy | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Thermotogamaritima) |
PF00496(SBP_bac_5) | 4 | ASN A 181VAL A 163THR A 53ILE A 54 | None | 1.01A | 4retA-4pfyA:undetectable | 4retA-4pfyA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4phb | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF14262(Cthe_2159) | 4 | ASN A 38VAL A 53THR A 72ILE A 41 | None | 1.43A | 4retA-4phbA:undetectable | 4retA-4phbA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ppy | PUTATIVEACYLHYDROLASE (Bacteroidesfragilis) |
PF13472(Lipase_GDSL_2) | 4 | ASN A 59VAL A 212THR A 151ILE A 170 | None | 1.36A | 4retA-4ppyA:2.7 | 4retA-4ppyA:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psj | OR464 (syntheticconstruct) |
PF12354(Internalin_N)PF13516(LRR_6)PF13855(LRR_8) | 4 | ASN A 80VAL A 63THR A 28ILE A 29 | None | 1.38A | 4retA-4psjA:undetectable | 4retA-4psjA:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASEDNA-DIRECTED RNAPOLYMERASE SUBUNIT P (Thermococcuskodakarensis) |
PF00562(RNA_pol_Rpb2_6)PF03604(DNA_RNApol_7kD)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 4 | ASN B 96VAL B 690THR B 857ILE P 34 | None | 1.40A | 4retA-4qiwB:undetectable | 4retA-4qiwB:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5c | LEUCINE RICH REPEATPROTEIN (syntheticconstruct) |
PF12354(Internalin_N)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 4 | ASN A 72VAL A 55THR A 20ILE A 21 | None | 1.39A | 4retA-4r5cA:undetectable | 4retA-4r5cA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5d | LEUCINE RICH REPEATPROTEIN (syntheticconstruct) |
PF12354(Internalin_N)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 4 | ASN A 72VAL A 55THR A 20ILE A 21 | None | 1.41A | 4retA-4r5dA:undetectable | 4retA-4r5dA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r6f | LEUCINE RICH REPEATDLRR_I (syntheticconstruct) |
PF12354(Internalin_N)PF13855(LRR_8) | 4 | ASN A 72VAL A 55THR A 20ILE A 21 | None | 1.40A | 4retA-4r6fA:undetectable | 4retA-4r6fA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r6g | LEUCINE RICH REPEATSDLRR_K (syntheticconstruct) |
PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 4 | ASN A 72VAL A 55THR A 20ILE A 21 | None | 1.35A | 4retA-4r6gA:undetectable | 4retA-4r6gA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rp8 | ASCORBATE-SPECIFICPERMEASE IICCOMPONENT ULAA (Escherichiacoli) |
PF03611(EIIC-GAT) | 4 | ASN A 232VAL A 327THR A 284ILE A 283 | None | 1.32A | 4retA-4rp8A:3.1 | 4retA-4rp8A:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uip | REPEBODY (RAC1) (Eptatretusburgeri;Listeriamonocytogenes;syntheticconstruct) |
PF11921(DUF3439)PF12354(Internalin_N)PF13855(LRR_8) | 4 | ASN B 74VAL B 57THR B 22ILE B 23 | None | 1.38A | 4retA-4uipB:undetectable | 4retA-4uipB:13.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wd2 | AROMATIC-AMINO-ACIDTRANSAMINASE TYRB (Burkholderiacenocepacia) |
PF00155(Aminotran_1_2) | 4 | ASN A 242VAL A 228THR A 97ILE A 95 | None | 1.21A | 4retA-4wd2A:undetectable | 4retA-4wd2A:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgt | FRQ-INTERACTING RNAHELICASE (Neurosporacrassa) |
PF00270(DEAD)PF00271(Helicase_C)PF08148(DSHCT)PF13234(rRNA_proc-arch) | 4 | ASN A 237VAL A 257THR A 269ILE A 272 | None | 1.17A | 4retA-4xgtA:2.2 | 4retA-4xgtA:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzo | PUTATIVE ACYL-COAACYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | ASN A 160VAL A 296THR A 274ILE A 153 | None | 1.45A | 4retA-4yzoA:undetectable | 4retA-4yzoA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzo | PUTATIVE ACYL-COAACYLTRANSFERASE (Sulfurisphaeratokodaii) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | ASN A 160VAL A 296THR A 274ILE A 275 | None | 1.38A | 4retA-4yzoA:undetectable | 4retA-4yzoA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxz | LEVOGLUCOSAN KINASE (Lipomycesstarkeyi) |
PF03702(AnmK) | 4 | ASN A 332VAL A 296THR A 303ILE A 302 | None | 0.99A | 4retA-4zxzA:undetectable | 4retA-4zxzA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bnn | CAPSID PROTEIN VP1CAPSID PROTEIN VP3CAPSID PROTEIN VP4 (Enterovirus D) |
PF00073(Rhv)PF02226(Pico_P1A) | 4 | ASN A 36VAL D 66THR C 164ILE C 163 | None | 1.18A | 4retA-5bnnA:undetectable | 4retA-5bnnA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c70 | GLUCURONIDASE (Aspergillusoryzae) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 4 | ASN A 286VAL A 239THR A 190ILE A 199 | None | 1.28A | 4retA-5c70A:undetectable | 4retA-5c70A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dpt | PLECKSTRIN HOMOLOGYDOMAIN-CONTAININGFAMILY M MEMBER 1,GAMMA-AMINOBUTYRICACIDRECEPTOR-ASSOCIATEDPROTEIN-LIKE1,GAMMA-AMINOBUTYRICACIDRECEPTOR-ASSOCIATEDPROTEIN-LIKE 1 (Homo sapiens) |
PF02991(Atg8) | 4 | ASN A 105VAL A 64THR A 90ILE A 91 | None | 1.37A | 4retA-5dptA:undetectable | 4retA-5dptA:9.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e02 | FRQ-INTERACTING RNAHELICASE (Neurosporacrassa) |
PF00270(DEAD)PF00271(Helicase_C)PF08148(DSHCT)PF13234(rRNA_proc-arch) | 4 | ASN A 237VAL A 257THR A 269ILE A 272 | NoneNone A C 4 ( 4.7A)None | 1.23A | 4retA-5e02A:undetectable | 4retA-5e02A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jd8 | PERIPLASMIC SERINEPEPTIDASE DEGS (Yersinia pestis) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 4 | ASN A 215VAL A 205THR A 191ILE A 172 | None | 1.50A | 4retA-5jd8A:undetectable | 4retA-5jd8A:17.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jh5 | LYSINE-SPECIFICDEMETHYLASE 2B (Homo sapiens) |
PF00646(F-box) | 4 | ASN A1108VAL A1155THR A1134ILE A1136 | None | 1.49A | 4retA-5jh5A:undetectable | 4retA-5jh5A:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsp | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF01437(PSI)PF01833(TIG) | 4 | ASN A 686VAL A 626THR A 582ILE A 583 | None | 1.44A | 4retA-5lspA:undetectable | 4retA-5lspA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5urb | METHIONINE--TRNALIGASE (Acinetobacterbaumannii) |
PF08264(Anticodon_1)PF09334(tRNA-synt_1g) | 4 | ASN A 327VAL A 538THR A 337ILE A 339 | None | 1.47A | 4retA-5urbA:2.4 | 4retA-5urbA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w4t | CADHERIN 23 (Danio rerio) |
no annotation | 4 | ASN C 8VAL C 93THR C 28ILE C 27 | None | 1.06A | 4retA-5w4tC:undetectable | 4retA-5w4tC:6.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yfb | DIPEPTIDYL PEPTIDASE3 (Armillariatabescens) |
no annotation | 4 | ASN A 208VAL A 205THR A 240ILE A 241 | None | 1.19A | 4retA-5yfbA:undetectable | 4retA-5yfbA:5.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6apx | MALTOSE-BINDINGPERIPLASMICPROTEIN,DUALSPECIFICITY PROTEINPHOSPHATASE 1 (Escherichiacoli;Homo sapiens) |
no annotation | 4 | ASN A1298VAL A1225THR A1267ILE A1268 | None | 1.23A | 4retA-6apxA:4.5 | 4retA-6apxA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c90 | EXOSOME RNA HELICASEMTR4,EXOSOME RNAHELICASE MTR4 (Homo sapiens) |
no annotation | 4 | ASN A 196VAL A 216THR A 228ILE A 231 | None | 1.10A | 4retA-6c90A:2.1 | 4retA-6c90A:9.11 |