SIMILAR PATTERNS OF AMINO ACIDS FOR 4R88_B_1LDB501_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bou | 4,5-DIOXYGENASE BETACHAIN (Sphingomonaspaucimobilis) |
PF02900(LigB) | 5 | HIS B 61HIS B 12GLU B 86ASP B 126SER B 63 | FE B 501 ( 3.3A) FE B 501 ( 3.3A)NoneNoneNone | 1.39A | 4r88B-1bouB:undetectable | 4r88B-1bouB:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0n | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Mus musculus) |
PF00268(Ribonuc_red_sm) | 5 | LEU A 73PHE A 273ILE A 91GLU A 153LEU A 74 | None | 0.96A | 4r88B-1h0nA:undetectable | 4r88B-1h0nA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1krm | ADENOSINE DEAMINASE (Bos taurus) |
PF00962(A_deaminase) | 5 | HIS A 14LEU A 55HIS A 211GLU A 214ASP A 292 | PRH A 401 ( 3.0A)None ZN A 501 ( 3.4A)PRH A 401 (-2.5A)PRH A 401 ( 2.5A) | 0.54A | 4r88B-1krmA:22.1 | 4r88B-1krmA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p1m | HYPOTHETICAL PROTEINTM0936 (Thermotogamaritima) |
PF01979(Amidohydro_1) | 5 | HIS A 57HIS A 200GLU A 203LEU A 257ASP A 279 | NI A9001 (-3.3A) NI A9001 (-3.4A)NoneNone NI A9001 (-2.6A) | 0.60A | 4r88B-1p1mA:35.7 | 4r88B-1p1mA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sjq | POLYPYRIMIDINETRACT-BINDINGPROTEIN 1 (Homo sapiens) |
no annotation | 5 | HIS A 20LEU A 47ILE A 26LEU A 94SER A 89 | None | 1.47A | 4r88B-1sjqA:undetectable | 4r88B-1sjqA:14.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uio | ADENOSINE DEAMINASE (Mus musculus) |
PF00962(A_deaminase) | 5 | HIS A 17LEU A 58HIS A 214GLU A 217ASP A 295 | HPR A 353 ( 3.1A)None ZN A 400 ( 3.3A)HPR A 353 (-2.7A)HPR A 353 ( 2.5A) | 0.37A | 4r88B-1uioA:22.9 | 4r88B-1uioA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8j | MYOSIN VA (Gallus gallus) |
PF00063(Myosin_head) | 5 | LEU A 682PHE A 673ILE A 110GLU A 82LEU A 688 | None | 1.28A | 4r88B-1w8jA:undetectable | 4r88B-1w8jA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xez | HEMOLYSIN (Vibrio cholerae) |
PF07968(Leukocidin)PF12563(Hemolysin_N)PF16458(Beta-prism_lec) | 5 | LEU A 290ILE A 388GLU A 189GLU A 135LEU A 139 | None | 1.21A | 4r88B-1xezA:undetectable | 4r88B-1xezA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ypx | PUTATIVE VITAMIN-B12INDEPENDENTMETHIONINE SYNTHASEFAMILY PROTEIN (Listeriamonocytogenes) |
PF01717(Meth_synt_2) | 5 | LEU A 264ILE A 225LEU A 260ASP A 188SER A 190 | None | 1.33A | 4r88B-1ypxA:7.9 | 4r88B-1ypxA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amx | ADENOSINE DEAMINASE (Plasmodiumyoelii) |
PF00962(A_deaminase) | 5 | HIS A 57HIS A 239GLU A 242LEU A 297ASP A 323 | CO A1000 (-3.2A) CO A1000 (-3.4A)UNX A2004 ( 4.8A)None CO A1000 (-2.7A) | 0.33A | 4r88B-2amxA:22.0 | 4r88B-2amxA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2az4 | HYPOTHETICAL PROTEINEF2904 (Enterococcusfaecalis) |
PF12706(Lactamase_B_2) | 5 | HIS A 97ILE A 403HIS A 404GLU A 216LEU A 190 | ZN A 602 (-3.3A)None ZN A 602 (-3.5A)NoneNone | 1.32A | 4r88B-2az4A:undetectable | 4r88B-2az4A:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ctm | VIGILIN (Homo sapiens) |
PF00013(KH_1) | 5 | HIS A 28PHE A 52ILE A 50GLU A 83LEU A 80 | None | 1.44A | 4r88B-2ctmA:undetectable | 4r88B-2ctmA:14.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dfs | MYOSIN-5A (Gallus gallus) |
PF00063(Myosin_head)PF00612(IQ) | 5 | LEU A 682PHE A 673ILE A 110GLU A 82LEU A 688 | None | 1.42A | 4r88B-2dfsA:undetectable | 4r88B-2dfsA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9u | CYTOSINE/GUANINEDEAMINASE RELATEDPROTEIN (Clostridiumacetobutylicum) |
PF01979(Amidohydro_1) | 6 | HIS A 75LEU A 90HIS A 229GLU A 232LEU A 298ASP A 320 | FE A 501 ( 3.6A)GUN A 503 (-4.9A)GUN A 503 ( 3.5A)GUN A 503 (-3.1A)None FE A 501 ( 2.7A) | 0.47A | 4r88B-2i9uA:31.8 | 4r88B-2i9uA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9u | CYTOSINE/GUANINEDEAMINASE RELATEDPROTEIN (Clostridiumacetobutylicum) |
PF01979(Amidohydro_1) | 5 | HIS A 75LEU A 298HIS A 229GLU A 232ASP A 320 | FE A 501 ( 3.6A)NoneGUN A 503 ( 3.5A)GUN A 503 (-3.1A) FE A 501 ( 2.7A) | 1.41A | 4r88B-2i9uA:31.8 | 4r88B-2i9uA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2imr | HYPOTHETICAL PROTEINDR_0824 (Deinococcusradiodurans) |
PF01979(Amidohydro_1) | 6 | HIS A 99HIS A 238GLU A 241LEU A 330ASP A 352SER A 353 | ZN A 500 (-3.2A) ZN A 500 (-3.2A)NoneNone ZN A 500 (-3.9A)None | 0.66A | 4r88B-2imrA:23.5 | 4r88B-2imrA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ood | BLR3880 PROTEIN (Bradyrhizobiumdiazoefficiens) |
PF01979(Amidohydro_1) | 6 | HIS A 81LEU A 95HIS A 234GLU A 237LEU A 302ASP A 326 | ZN A 500 ( 3.3A)GUN A 600 (-3.1A)GUN A 600 ( 2.8A)GUN A 600 (-2.8A)NoneGUN A 600 ( 2.5A) | 0.50A | 4r88B-2oodA:28.5 | 4r88B-2oodA:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgm | SUCCINOGLYCANBIOSYNTHESIS PROTEIN (Bacillus cereus) |
PF05139(Erythro_esteras) | 5 | HIS A 435LEU A 426PHE A 386ILE A 45LEU A 407 | None | 1.47A | 4r88B-2qgmA:undetectable | 4r88B-2qgmA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qsj | DNA-BINDING RESPONSEREGULATOR, LUXRFAMILY (Ruegeriapomeroyi) |
PF00072(Response_reg) | 5 | HIS A 114LEU A 20GLN A 110LEU A 21SER A 117 | None | 1.44A | 4r88B-2qsjA:2.3 | 4r88B-2qsjA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3v | MEVALONATE KINASE (Homo sapiens) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | LEU A 305ILE A 271HIS A 17GLU A 19LEU A 331 | None | 1.39A | 4r88B-2r3vA:undetectable | 4r88B-2r3vA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjq | ADAMTS-5 (Homo sapiens) |
PF01421(Reprolysin) | 5 | LEU A 291ILE A 363LEU A 287ASP A 276SER A 278 | None | 1.39A | 4r88B-2rjqA:undetectable | 4r88B-2rjqA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vx4 | CELLVIBRIO JAPONICUSMANNANASE CJMAN26C (Cellvibriojaponicus) |
PF02156(Glyco_hydro_26) | 5 | HIS A 156PHE A 227HIS A 220GLU A 338GLU A 85 | GOL A1420 ( 4.1A)NoneNoneNoneNone | 1.21A | 4r88B-2vx4A:6.3 | 4r88B-2vx4A:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0q | ALCALIGINBIOSYNTHESIS PROTEIN (Bordetellabronchiseptica) |
PF04183(IucA_IucC)PF06276(FhuF) | 5 | ILE A 563HIS A 564GLU A 509GLU A 39LEU A 567 | None | 1.38A | 4r88B-2x0qA:undetectable | 4r88B-2x0qA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aw9 | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Pyrobaculumcalidifontis) |
PF01370(Epimerase) | 5 | LEU A 168ILE A 12HIS A 15GLU A 305LEU A 302 | NoneNAD A 901 (-4.4A)NoneNoneNone | 1.49A | 4r88B-3aw9A:undetectable | 4r88B-3aw9A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdw | NKG2-A/NKG2-B TYPEII INTEGRAL MEMBRANEPROTEIN (Homo sapiens) |
PF00059(Lectin_C) | 5 | LEU B 211PHE B 194HIS B 196GLU B 162LEU B 166 | None | 1.12A | 4r88B-3bdwB:undetectable | 4r88B-3bdwB:14.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0l | GUANINE DEAMINASE (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | HIS A 84HIS A 238GLU A 241LEU A 306ASP A 328 | ZN A1452 (-3.1A) ZN A1452 (-3.2A)NoneNone ZN A1452 (-2.8A) | 0.48A | 4r88B-3e0lA:31.5 | 4r88B-3e0lA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewd | ADENOSINE DEAMINASE (Plasmodiumvivax) |
PF00962(A_deaminase) | 6 | HIS A 44LEU A 85HIS A 225GLU A 228LEU A 283ASP A 309 | MCF A 372 ( 3.3A)MCF A 372 (-4.7A) ZN A 371 ( 3.4A)MCF A 372 (-2.8A)NoneMCF A 372 ( 2.4A) | 0.45A | 4r88B-3ewdA:22.8 | 4r88B-3ewdA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewd | ADENOSINE DEAMINASE (Plasmodiumvivax) |
PF00962(A_deaminase) | 5 | HIS A 44LEU A 85HIS A 225LEU A 283ASP A 310 | MCF A 372 ( 3.3A)MCF A 372 (-4.7A) ZN A 371 ( 3.4A)NoneMCF A 372 (-2.9A) | 1.41A | 4r88B-3ewdA:22.8 | 4r88B-3ewdA:23.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g77 | CYTOSINE DEAMINASE (Escherichiacoli) |
PF07969(Amidohydro_3) | 10 | HIS A 63LEU A 81PHE A 154GLN A 156ILE A 183HIS A 214GLU A 217LEU A 282ASP A 313TRP A 319 | FE A 502 (-3.1A)NoneNoneNoneNone FE A 502 (-3.6A)NoneNone FE A 502 (-3.2A)None | 0.32A | 4r88B-3g77A:68.7 | 4r88B-3g77A:54.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpa | AMIDOHYDROLASE (unidentified) |
PF01979(Amidohydro_1) | 5 | HIS A 95LEU A 112HIS A 259LEU A 325ASP A 347 | ZN A 480 (-3.3A)None ZN A 480 (-3.5A)None ZN A 480 (-3.2A) | 0.73A | 4r88B-3hpaA:34.8 | 4r88B-3hpaA:25.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3io1 | AMINOBENZOYL-GLUTAMATE UTILIZATIONPROTEIN (Klebsiellapneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | HIS A 153ILE A 395HIS A 208GLU A 375ASP A 116 | NoneNoneNoneNone NA A 501 (-3.0A) | 1.30A | 4r88B-3io1A:undetectable | 4r88B-3io1A:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lgg | ADENOSINE DEAMINASECECR1 (Homo sapiens) |
PF00962(A_deaminase)PF08451(A_deaminase_N) | 5 | HIS A 88HIS A 330GLU A 333LEU A 389ASP A 415 | CFE A 513 ( 3.3A) ZN A 512 ( 3.5A)CFE A 513 (-3.0A)NoneCFE A 513 ( 2.8A) | 0.37A | 4r88B-3lggA:21.0 | 4r88B-3lggA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lnp | AMIDOHYDROLASEFAMILY PROTEINOLEI01672_1_465 (Oleispiraantarctica) |
PF01979(Amidohydro_1) | 5 | HIS A 90HIS A 243GLU A 246LEU A 309ASP A 331 | CA A 471 (-3.6A) CA A 471 (-4.7A)NoneNone CA A 471 (-2.7A) | 0.96A | 4r88B-3lnpA:31.1 | 4r88B-3lnpA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | HIS A 56LEU A 298HIS A 232GLU A 235GLU A 295 | ZN A 454 (-3.3A)NGQ A 455 (-4.7A) ZN A 454 (-3.3A)NGQ A 455 (-2.9A)None | 1.33A | 4r88B-3mduA:30.1 | 4r88B-3mduA:27.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | HIS A 58HIS A 232GLU A 235LEU A 298ASP A 320 | ZN A 454 ( 3.2A) ZN A 454 (-3.3A)NGQ A 455 (-2.9A)NGQ A 455 (-4.7A) ZN A 454 (-2.9A) | 0.54A | 4r88B-3mduA:30.1 | 4r88B-3mduA:27.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | HIS A 232GLU A 235LEU A 298ASP A 320SER A 321 | ZN A 454 (-3.3A)NGQ A 455 (-2.9A)NGQ A 455 (-4.7A) ZN A 454 (-2.9A)None | 1.01A | 4r88B-3mduA:30.1 | 4r88B-3mduA:27.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mn3 | CARBONCATABOLITE-DEREPRESSING PROTEIN KINASE (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | LEU A 242ILE A 300GLU A 151LEU A 246SER A 276 | None | 1.21A | 4r88B-3mn3A:undetectable | 4r88B-3mn3A:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ob8 | BETA-GALACTOSIDASE (Kluyveromyceslactis) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N) | 5 | HIS A 647LEU A 348GLN A 567ILE A 643GLU A 688 | None | 1.33A | 4r88B-3ob8A:6.3 | 4r88B-3ob8A:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oun | PUTATIVEUNCHARACTERIZEDPROTEIN TB39.8 (Mycobacteriumtuberculosis) |
PF00498(FHA) | 5 | LEU A 61ILE A 106GLU A 62LEU A 75SER A 38 | None | 1.47A | 4r88B-3ounA:undetectable | 4r88B-3ounA:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 6 | HIS A 18LEU A 56HIS A 196GLU A 199LEU A 251ASP A 277 | ADE A 328 ( 3.0A)ADE A 328 (-4.6A) ZN A 327 ( 3.5A)ADE A 328 (-3.0A)None ZN A 327 ( 2.6A) | 0.32A | 4r88B-3paoA:23.5 | 4r88B-3paoA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 5 | HIS A 18LEU A 56HIS A 196LEU A 251ASP A 278 | ADE A 328 ( 3.0A)ADE A 328 (-4.6A) ZN A 327 ( 3.5A)NoneADE A 328 (-2.8A) | 1.48A | 4r88B-3paoA:23.5 | 4r88B-3paoA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 5 | HIS A 18PHE A 98HIS A 16LEU A 56ASP A 278 | ADE A 328 ( 3.0A)None ZN A 327 (-3.4A)ADE A 328 (-4.6A)ADE A 328 (-2.8A) | 1.48A | 4r88B-3paoA:23.5 | 4r88B-3paoA:24.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qki | GLUCOSE-6-PHOSPHATEISOMERASE (Plasmodiumfalciparum) |
PF00342(PGI) | 5 | LEU A 342PHE A 370ILE A 428GLU A 426SER A 378 | None | 1.06A | 4r88B-3qkiA:undetectable | 4r88B-3qkiA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rf7 | IRON-CONTAININGALCOHOLDEHYDROGENASE (Shewanelladenitrificans) |
PF00465(Fe-ADH) | 5 | HIS A 272ILE A 249HIS A 198GLU A 201SER A 261 | NI A 361 (-3.4A)None FE A 360 ( 3.4A)NoneNone | 1.29A | 4r88B-3rf7A:undetectable | 4r88B-3rf7A:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rys | ADENOSINE DEAMINASE1 (Paenarthrobacteraurescens) |
PF00962(A_deaminase) | 6 | HIS A 21LEU A 59HIS A 199GLU A 202LEU A 254ASP A 280 | ADE A 345 ( 3.2A)ADE A 345 (-4.5A) ZN A 344 ( 3.4A)ADE A 345 (-2.8A)None ZN A 344 ( 2.5A) | 0.36A | 4r88B-3rysA:23.9 | 4r88B-3rysA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rys | ADENOSINE DEAMINASE1 (Paenarthrobacteraurescens) |
PF00962(A_deaminase) | 5 | HIS A 21LEU A 59HIS A 199LEU A 254ASP A 281 | ADE A 345 ( 3.2A)ADE A 345 (-4.5A) ZN A 344 ( 3.4A)NoneADE A 345 (-2.8A) | 1.43A | 4r88B-3rysA:23.9 | 4r88B-3rysA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uc3 | SERINE/THREONINE-PROTEIN KINASE SRK2I (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | LEU A 208ILE A 272GLU A 115LEU A 212SER A 248 | None | 1.16A | 4r88B-3uc3A:undetectable | 4r88B-3uc3A:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3udb | SERINE/THREONINE-PROTEIN KINASE SRK2E (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | LEU A 207ILE A 271GLU A 114LEU A 211SER A 247 | None | 1.23A | 4r88B-3udbA:undetectable | 4r88B-3udbA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujg | SERINE/THREONINE-PROTEIN KINASE SRK2E (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | LEU A 207ILE A 271GLU A 114LEU A 211SER A 247 | None | 1.23A | 4r88B-3ujgA:undetectable | 4r88B-3ujgA:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7p | AMIDOHYDROLASEFAMILY PROTEIN (Nitratiruptorsp. SB155-2) |
PF01979(Amidohydro_1) | 5 | HIS A 63HIS A 206GLU A 209LEU A 286ASP A 306 | FE A 429 (-3.2A) FE A 429 (-3.3A)UNL A 436 ( 2.8A)None FE A 429 (-3.1A) | 0.31A | 4r88B-3v7pA:33.9 | 4r88B-3v7pA:26.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7p | AMIDOHYDROLASEFAMILY PROTEIN (Nitratiruptorsp. SB155-2) |
PF01979(Amidohydro_1) | 5 | HIS A 63HIS A 206GLU A 209LEU A 286SER A 309 | FE A 429 (-3.2A) FE A 429 (-3.3A)UNL A 436 ( 2.8A)NoneUNL A 437 ( 3.1A) | 1.15A | 4r88B-3v7pA:33.9 | 4r88B-3v7pA:26.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dyk | AMIDOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | HIS A 74HIS A 221GLU A 224LEU A 287ASP A 309 | ZN A 501 (-3.2A) ZN A 501 (-3.3A)NoneNone ZN A 501 (-2.6A) | 0.49A | 4r88B-4dykA:35.3 | 4r88B-4dykA:25.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzh | AMIDOHYDROLASE (Xanthomonascampestris) |
PF01979(Amidohydro_1) | 5 | HIS A 80HIS A 227GLU A 230LEU A 293ASP A 315 | ZN A 504 (-3.1A) ZN A 504 (-3.3A) ZN A 505 ( 4.2A)None ZN A 505 ( 2.0A) | 0.53A | 4r88B-4dzhA:34.3 | 4r88B-4dzhA:25.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0l | AMIDOHYDROLASE (Brucellaabortus) |
PF01979(Amidohydro_1) | 5 | HIS A 63HIS A 237GLU A 240LEU A 303ASP A 325 | FE A 501 (-3.4A) FE A 501 (-3.5A)NoneNone FE A 501 (-2.8A) | 0.48A | 4r88B-4f0lA:30.9 | 4r88B-4f0lA:24.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0s | 5-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE DEAMINASE (Chromobacteriumviolaceum) |
PF01979(Amidohydro_1) | 6 | HIS A 72LEU A 87HIS A 219GLU A 222LEU A 285ASP A 307 | NOS A 501 (-3.7A)NOS A 501 (-4.8A)NOS A 501 (-3.5A)NOS A 501 (-3.0A)NoneNOS A 501 (-2.8A) | 0.60A | 4r88B-4f0sA:35.7 | 4r88B-4f0sA:25.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h5u | PROBABLE HYDROLASENIT2 (Saccharomycescerevisiae) |
PF00795(CN_hydrolase) | 5 | HIS A 93LEU A 130ILE A 168GLU A 143SER A 57 | NoneNoneCAF A 169 ( 3.9A)CAF A 169 ( 4.8A)None | 1.37A | 4r88B-4h5uA:2.8 | 4r88B-4h5uA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwm | UPF0135 PROTEINMJ0927 (Methanocaldococcusjannaschii) |
PF01784(NIF3) | 5 | HIS A 103LEU A 49GLU A 225LEU A 229ASP A 107 | None | 1.14A | 4r88B-4iwmA:undetectable | 4r88B-4iwmA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kt1 | LEUCINE-RICHREPEAT-CONTAININGG-PROTEIN COUPLEDRECEPTOR 4 (Homo sapiens) |
PF01462(LRRNT)PF13516(LRR_6)PF13855(LRR_8) | 5 | LEU A 425PHE A 409ILE A 380GLU A 449LEU A 447 | None | 1.39A | 4r88B-4kt1A:undetectable | 4r88B-4kt1A:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ptf | DNA POLYMERASEEPSILON CATALYTICSUBUNIT A (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | HIS A 823LEU A 515PHE A 492ILE A 493LEU A 519 | None | 1.46A | 4r88B-4ptfA:undetectable | 4r88B-4ptfA:17.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r85 | CYTOSINE DEAMINASE (Klebsiellapneumoniae) |
PF07969(Amidohydro_3) | 12 | HIS A 58LEU A 76PHE A 149GLN A 151ILE A 178HIS A 209GLU A 212GLU A 273LEU A 277ASP A 308SER A 309TRP A 314 | FE2 A 502 ( 3.5A)17E A 501 (-4.9A)17E A 501 (-4.9A)17E A 501 (-2.9A)NoneFE2 A 502 ( 3.4A)17E A 501 (-2.9A)17E A 501 (-4.3A)NoneFE2 A 502 ( 2.8A)17E A 501 (-3.2A)17E A 501 (-3.4A) | 0.14A | 4r88B-4r85A:72.6 | 4r88B-4r85A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v1y | ATRAZINECHLOROHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 5 | HIS A 68HIS A 243GLU A 246LEU A 305ASP A 327 | FE A 481 (-3.9A) FE A 481 (-4.1A) FE A 481 ( 4.3A)None FE A 481 (-2.8A) | 0.40A | 4r88B-4v1yA:32.8 | 4r88B-4v1yA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f64 | POSITIVETRANSCRIPTIONREGULATOR EVGA (Shigellaflexneri) |
PF00072(Response_reg)PF00196(GerE) | 5 | LEU A 186PHE A 86ILE A 203GLU A 148SER A 145 | None | 1.44A | 4r88B-5f64A:2.6 | 4r88B-5f64A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j8j | HISTONE DEACETYLASEHDA1 (Saccharomycescerevisiae) |
PF09757(Arb2) | 5 | HIS A 507LEU A 491LEU A 469ASP A 532SER A 534 | None | 1.30A | 4r88B-5j8jA:undetectable | 4r88B-5j8jA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ndx | GLYCOSYL HYDROLASE (Rhizobiumleguminosarum) |
no annotation | 5 | HIS A 220GLU A 95GLU A 142ASP A 264SER A 218 | 8U8 A 712 ( 4.7A)NoneNoneNoneNone | 1.41A | 4r88B-5ndxA:6.1 | 4r88B-5ndxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nmp | ISATIN HYDROLASE (Ralstoniasolanacearum) |
no annotation | 5 | HIS A 84GLN A 226ILE A 197GLU A 73SER A 252 | SIN A 302 (-3.7A) MN A 301 ( 3.0A)NoneNoneNone | 1.21A | 4r88B-5nmpA:undetectable | 4r88B-5nmpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olk | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE,BETA SUBUNIT 1 (Leeuwenhoekiellablandensis) |
no annotation | 5 | PHE A 107ILE A 312GLU A 250ASP A 247SER A 245 | None | 1.38A | 4r88B-5olkA:undetectable | 4r88B-5olkA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ovn | POL PROTEIN (Felineimmunodeficiencyvirus) |
no annotation | 5 | HIS A 197LEU A 108ILE A 179GLU A 222LEU A 220 | None | 1.12A | 4r88B-5ovnA:undetectable | 4r88B-5ovnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ux5 | BIFUNCTIONAL PROTEINPROLINE UTILIZATIONA (PUTA) (Corynebacteriumfreiburgense) |
PF00171(Aldedh)PF01619(Pro_dh) | 5 | LEU A 859GLU A 856LEU A 831ASP A 853SER A 851 | None | 1.48A | 4r88B-5ux5A:8.0 | 4r88B-5ux5A:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v7v | ERAD-ASSOCIATED E3UBIQUITIN-PROTEINLIGASE COMPONENTHRD3 (Saccharomycescerevisiae) |
PF08238(Sel1) | 5 | LEU A 93PHE A 120ILE A 112GLU A 91LEU A 92 | None | 1.33A | 4r88B-5v7vA:undetectable | 4r88B-5v7vA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wax | - (-) |
no annotation | 5 | LEU A 199ILE A 263GLU A 106LEU A 203SER A 239 | None | 1.18A | 4r88B-5waxA:undetectable | 4r88B-5waxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wht | PUTATIVEPERTUSSIS-LIKE TOXINSUBUNIT (Salmonellaenterica) |
no annotation | 5 | LEU A 125PHE A 53ILE A 55GLU A 84SER A 81 | None | 1.42A | 4r88B-5whtA:undetectable | 4r88B-5whtA:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6btg | FUCULOSE PHOSPHATEALDOLASE (Bacillusthuringiensis) |
no annotation | 5 | HIS A 97LEU A 138ILE A 160HIS A 95GLU A 76 | MN A 301 ( 3.3A)NoneNone MN A 301 (-3.3A)13P A 302 ( 3.6A) | 1.43A | 4r88B-6btgA:undetectable | 4r88B-6btgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c0f | RIBOSOME BIOGENESISPROTEIN SSF1 (Saccharomycescerevisiae) |
no annotation | 5 | LEU v 339ILE v 342HIS v 353GLU v 355ASP v 158 | None | 1.39A | 4r88B-6c0fv:undetectable | 4r88B-6c0fv:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhw | GLUCOAMYLASE P (Amorphothecaresinae) |
no annotation | 5 | HIS A 301LEU A 252ILE A 261LEU A 249SER A 294 | None | 1.28A | 4r88B-6fhwA:undetectable | 4r88B-6fhwA:undetectable |