SIMILAR PATTERNS OF AMINO ACIDS FOR 4R87_I_SPMI202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		4 ASN A 162
GLU A 167
TYR A 164
GLU A 160
 None
 1.18A 4r87I-1ajzA:
1.8		 4r87I-1ajzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bik BIKUNIN

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		4 ASN A  45
GLU A  69
TYR A  42
GLU A  52
 NAG  A 148 (-1.7A)
None
None
NAG  A 148 ( 4.0A)
 1.31A 4r87I-1bikA:
undetectable		 4r87I-1bikA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
 None
 1.30A 4r87I-1c7tA:
0.0		 4r87I-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16) 		4 ASN B 352
GLU B 227
GLU B 228
TYR B 353
 None
 1.32A 4r87I-1ezvB:
0.0		 4r87I-1ezvB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		4 MET A 175
GLU A 146
GLU A 147
TYR A 148
 None
 1.03A 4r87I-1h14A:
0.0		 4r87I-1h14A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		4 ASN A 117
GLU A 110
GLU A  15
GLU A  14
 None
 1.01A 4r87I-1ibqA:
0.0		 4r87I-1ibqA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ASN A 178
GLU A 180
TYR A 182
GLU A 181
 None
 1.25A 4r87I-1k20A:
0.0		 4r87I-1k20A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ASN A  81
GLU A  80
GLU A  84
GLU A  78
 None
 1.15A 4r87I-1lamA:
0.0		 4r87I-1lamA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASN A 503
GLU A 495
GLU A 410
TYR A 505
 None
 1.28A 4r87I-1m53A:
0.7		 4r87I-1m53A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s66 HYPOTHETICAL PROTEIN
YDDU

(Escherichia
coli) 		PF13426
(PAS_9) 		4 GLU L  58
GLU L  59
TYR L  55
GLU L  50
 None
 1.21A 4r87I-1s66L:
undetectable		 4r87I-1s66L:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp6 HYPOTHETICAL PROTEIN
PA1314

(Pseudomonas
aeruginosa) 		PF14534
(DUF4440) 		4 GLU A  72
GLU A  92
TYR A  90
GLU A  76
 None
 1.32A 4r87I-1tp6A:
undetectable		 4r87I-1tp6A:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u83 PHOSPHOSULFOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF02679
(ComA) 		4 MET A 160
GLU A 161
GLU A 158
TYR A 155
 None
 1.07A 4r87I-1u83A:
undetectable		 4r87I-1u83A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us8 DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Pyrococcus
furiosus) 		PF13476
(AAA_23) 		4 ASN A  26
GLU A  20
GLU A   4
GLU A  23
 None
 1.19A 4r87I-1us8A:
undetectable		 4r87I-1us8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcm DNA-DIRECTED RNA
POLYMERASE II 32 KDA
POLYPEPTIDE

(Saccharomyces
cerevisiae) 		PF03874
(RNA_pol_Rpb4) 		4 ASN D  39
GLU D  43
GLU D  44
GLU D  45
 None
 0.94A 4r87I-1wcmD:
undetectable		 4r87I-1wcmD:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ASN A  56
GLU A  58
GLU A  61
TYR A  60
 None
 1.11A 4r87I-1x87A:
undetectable		 4r87I-1x87A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ASN A 321
GLU A 378
GLU A 382
GLU A 323
 None
MAN  A3005 (-2.9A)
None
MAN  A3007 (-3.5A)
 1.24A 4r87I-1xc6A:
undetectable		 4r87I-1xc6A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwm PHOSPHATE UPTAKE
REGULATOR

(Geobacillus
stearothermophilus) 		PF01895
(PhoU) 		4 ASN A  60
GLU A  57
GLU A  58
GLU A  56
 None
 1.22A 4r87I-1xwmA:
undetectable		 4r87I-1xwmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl9 GLUTATHIONE
S-TRANSFERASE 5

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.23A 4r87I-1zl9A:
undetectable		 4r87I-1zl9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		4 GLU A 750
GLU A 751
TYR A 747
GLU A 749
 None
 1.22A 4r87I-2aqxA:
undetectable		 4r87I-2aqxA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpt VACUOLAR SORTING
PROTEIN 4B

(Homo sapiens) 		PF04212
(MIT) 		4 ASN A  33
GLU A  35
TYR A  41
GLU A  28
 None
 1.23A 4r87I-2cptA:
undetectable		 4r87I-2cptA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl5 PUTATIVE DEHYDRATASE
PROTEIN

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A 389
GLU A 393
TYR A 394
GLU A 361
 None
 1.06A 4r87I-2gl5A:
1.7		 4r87I-2gl5A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 1.03A 4r87I-2gp6A:
undetectable		 4r87I-2gp6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nck NUCLEOSIDE
DIPHOSPHATE KINASE

(Myxococcus
xanthus) 		no annotation 4 ASN R  81
GLU R  80
GLU R  78
GLU R   4
 None
 1.35A 4r87I-2nckR:
2.3		 4r87I-2nckR:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5k ARGININE REPRESSOR

(Bacillus
subtilis) 		PF01316
(Arg_repressor) 		4 ASN A  17
GLU A  18
TYR A  62
GLU A  24
 None
 1.14A 4r87I-2p5kA:
undetectable		 4r87I-2p5kA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE

(Bacillus
anthracis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ASN A 346
GLU A 341
TYR A 339
GLU A 252
 None
 1.36A 4r87I-2pfmA:
undetectable		 4r87I-2pfmA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 ASN A 290
GLU A 283
TYR A 286
GLU A 389
 None
None
None
CPS  A 777 (-3.5A)
 1.07A 4r87I-2punA:
undetectable		 4r87I-2punA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 ASN A 112
GLU A 116
GLU A 117
GLU A  71
 None
 1.31A 4r87I-2r66A:
undetectable		 4r87I-2r66A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		4 MET A 157
GLU A 154
GLU A 155
GLU A 308
 None
 1.19A 4r87I-2veoA:
0.6		 4r87I-2veoA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 GLU A 211
GLU A 212
TYR A 208
GLU A 213
 None
 1.36A 4r87I-2wnwA:
undetectable		 4r87I-2wnwA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
BETA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF12838
(Fer4_7) 		4 GLU B 330
GLU B 168
GLU B 172
GLU B 171
 None
 1.27A 4r87I-2xsjB:
undetectable		 4r87I-2xsjB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLU A  59
GLU A  60
GLU A  20
GLU A 364
 None
 1.08A 4r87I-2yxxA:
undetectable		 4r87I-2yxxA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.18A 4r87I-2yyyA:
undetectable		 4r87I-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		4 ASN A 356
GLU A 281
TYR A 354
GLU A 355
 None
 1.03A 4r87I-2z61A:
undetectable		 4r87I-2z61A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		4 ASN A 155
GLU A 160
GLU A 161
GLU A 153
 None
 1.20A 4r87I-2zskA:
undetectable		 4r87I-2zskA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx GEMININ

(Mus musculus) 		PF07412
(Geminin) 		4 ASN A 114
GLU A 113
GLU A 109
TYR A 108
 None
 1.12A 4r87I-2zxxA:
undetectable		 4r87I-2zxxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli) 		PF05985
(EutC) 		4 ASN B 177
GLU B 180
GLU B 179
TYR B 178
 None
 1.35A 4r87I-3absB:
undetectable		 4r87I-3absB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c37 PEPTIDASE, M48
FAMILY

(Geobacter
sulfurreducens) 		PF01435
(Peptidase_M48) 		4 ASN A 109
GLU A 162
TYR A 157
GLU A 107
 None
ZN  A 301 (-2.2A)
None
None
 1.03A 4r87I-3c37A:
undetectable		 4r87I-3c37A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD

(Chromobacterium
violaceum) 		no annotation 4 ASN A  34
GLU A 118
GLU A  36
GLU A  38
 FAD  A 401 (-3.6A)
None
None
None
 1.22A 4r87I-3c4aA:
undetectable		 4r87I-3c4aA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6f CG18548-PA
(IP02196P)
(IP02193P)

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ASN A 127
GLU A 126
GLU A 125
TYR A 128
 None
 1.10A 4r87I-3f6fA:
undetectable		 4r87I-3f6fA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Bos taurus) 		PF06052
(3-HAO) 		4 GLU A  49
GLU A 112
GLU A  52
GLU A 208
 None
 1.37A 4r87I-3fe5A:
undetectable		 4r87I-3fe5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fve DIAMINOPIMELATE
EPIMERASE

(Mycobacterium
tuberculosis) 		PF01678
(DAP_epimerase) 		4 ASN A 199
GLU A 217
GLU A 222
GLU A 201
 None
 1.25A 4r87I-3fveA:
undetectable		 4r87I-3fveA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g65 CHECKPOINT PROTEIN
HUS1

(Homo sapiens) 		PF04005
(Hus1) 		4 ASN C 191
GLU C 195
GLU C 183
GLU C 229
 None
 1.20A 4r87I-3g65C:
undetectable		 4r87I-3g65C:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLU A 106
GLU A 102
TYR A 107
GLU A 104
 None
 1.23A 4r87I-3h9uA:
undetectable		 4r87I-3h9uA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima) 		PF00154
(RecA) 		4 ASN A 195
GLU A 209
GLU A 226
GLU A  65
 None
 0.96A 4r87I-3hr8A:
undetectable		 4r87I-3hr8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ASN A 486
GLU A 487
GLU A 488
GLU A 517
 None
 1.32A 4r87I-3hztA:
undetectable		 4r87I-3hztA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 A223 PENTON BASE

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 ASN Q 139
GLU Q 221
GLU Q 220
TYR Q 140
 None
 1.21A 4r87I-3j31Q:
undetectable		 4r87I-3j31Q:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv3 INTERSECTIN-1

(Mus musculus) 		PF00621
(RhoGEF)
PF14604
(SH3_9) 		4 ASN A1247
GLU A1243
GLU A1242
TYR A1245
 None
 1.25A 4r87I-3jv3A:
undetectable		 4r87I-3jv3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyf PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF07238
(PilZ)
PF07317
(YcgR) 		4 ASN A 170
GLU A 206
GLU A 205
GLU A 172
 None
 1.26A 4r87I-3kyfA:
undetectable		 4r87I-3kyfA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		4 ASN A  74
MET A  78
TYR A 430
GLU A  44
 None
 1.34A 4r87I-3lggA:
undetectable		 4r87I-3lggA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcr NADH DEHYDROGENASE,
SUBUNIT C

(Thermobifida
fusca) 		PF00329
(Complex1_30kDa) 		4 GLU A 147
GLU A 145
TYR A 143
GLU A 150
 None
 1.24A 4r87I-3mcrA:
undetectable		 4r87I-3mcrA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na7 HP0958

(Helicobacter
pylori) 		PF02591
(zf-RING_7) 		4 ASN A  48
GLU A  51
GLU A  50
GLU A  52
 None
 1.29A 4r87I-3na7A:
undetectable		 4r87I-3na7A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1031 (-3.9A)
MAN  A1028 (-2.7A)
None
MAN  A1029 (-3.5A)
 1.18A 4r87I-3ogrA:
undetectable		 4r87I-3ogrA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd8 PROBABLE
BACTERIOFERRITIN
BFRB

(Mycobacterium
tuberculosis) 		PF00210
(Ferritin) 		4 ASN A  57
GLU A  22
GLU A  54
GLU A 135
 None
 1.22A 4r87I-3qd8A:
undetectable		 4r87I-3qd8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf2 30S RIBOSOMAL
PROTEIN S8

(Aquifex
aeolicus) 		PF00410
(Ribosomal_S8) 		4 GLU A  59
GLU A  58
TYR A  57
GLU A  60
 None
 1.21A 4r87I-3rf2A:
1.8		 4r87I-3rf2A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		4 GLU A 137
GLU A 136
TYR A 134
GLU A 203
 None
 1.31A 4r87I-3s6pA:
undetectable		 4r87I-3s6pA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASN A 488
MET A  66
GLU A  62
GLU A 493
 None
 1.03A 4r87I-3sdqA:
undetectable		 4r87I-3sdqA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh7 CP32M

(-) 		no annotation 4 ASN B 624
GLU B 625
GLU B 630
GLU B 622
 None
 1.32A 4r87I-3vh7B:
undetectable		 4r87I-3vh7B:
11.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		6 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.55A 4r87I-3wr7A:
28.3		 4r87I-3wr7A:
57.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		4 GLU A 165
TYR A 113
GLU A 169
GLU A 205
 None
None
TRS  A1352 (-2.8A)
None
 1.33A 4r87I-3zizA:
undetectable		 4r87I-3zizA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		4 MET A 157
GLU A 154
GLU A 155
GLU A 308
 None
 1.35A 4r87I-3zpxA:
0.3		 4r87I-3zpxA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amf PHOX

(Pseudomonas
fluorescens) 		PF05787
(DUF839) 		4 ASN A  68
GLU A  90
TYR A  91
GLU A 532
 None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
 1.30A 4r87I-4amfA:
undetectable		 4r87I-4amfA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		4 ASN A 657
GLU A 656
GLU A 655
GLU A 659
 None
 1.27A 4r87I-4dloA:
undetectable		 4r87I-4dloA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 ASN A 489
GLU A  91
GLU A 490
GLU A  98
 FAD  A 501 (-4.4A)
None
None
None
 1.30A 4r87I-4dnsA:
undetectable		 4r87I-4dnsA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		4 ASN A 366
GLU A 368
TYR A 370
GLU A 369
 None
 1.37A 4r87I-4dweA:
undetectable		 4r87I-4dweA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ASN A 324
GLU A 322
GLU A 319
TYR A 326
 None
None
None
TPO  A 308 ( 4.5A)
 1.34A 4r87I-4gv1A:
0.1		 4r87I-4gv1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he4 YELLOW FLUORESCENT
PROTEIN

(Phialidium sp.
SL-2003) 		PF01353
(GFP) 		4 ASN A 119
GLU A 113
TYR A 118
GLU A  17
 CRO  A  65 ( 4.0A)
None
None
None
 1.27A 4r87I-4he4A:
undetectable		 4r87I-4he4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwb FLIC, FLIS CHIMERA

(Aquifex
aeolicus) 		PF00700
(Flagellin_C)
PF02561
(FliS) 		4 ASN A  95
GLU A  71
GLU A  74
GLU A  78
 None
 1.32A 4r87I-4iwbA:
undetectable		 4r87I-4iwbA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb3 HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 ASN A 109
GLU A  51
TYR A 141
GLU A  50
 None
None
None
GOL  A 302 (-2.8A)
 1.21A 4r87I-4jb3A:
undetectable		 4r87I-4jb3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq8 CYTOCHROME P450 19A1

(Homo sapiens) 		PF00067
(p450) 		4 GLU A 416
GLU A 362
TYR A 366
GLU A 412
 None
 1.35A 4r87I-4kq8A:
undetectable		 4r87I-4kq8A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 GLU A 268
GLU A 267
TYR A 266
GLU A 269
 None
 1.28A 4r87I-4ktpA:
undetectable		 4r87I-4ktpA:
14.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		7 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.71A 4r87I-4mi4A:
30.1		 4r87I-4mi4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnu SLYA-LIKE
TRANSCRIPTION
REGULATOR

(Listeria
monocytogenes) 		PF01047
(MarR) 		4 ASN A 105
TYR A 107
GLU A 104
GLU A  22
 None
 1.20A 4r87I-4mnuA:
undetectable		 4r87I-4mnuA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqa POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg)
PF05406
(WGR) 		4 ASN C 767
MET C 686
GLU C 688
GLU C 763
 None
 1.29A 4r87I-4oqaC:
undetectable		 4r87I-4oqaC:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		4 ASN A  72
GLU A  75
TYR A  74
GLU A  77
 None
 1.04A 4r87I-4rgpA:
undetectable		 4r87I-4rgpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 4 GLU D 274
GLU D 267
GLU D 265
GLU D 240
 None
 1.29A 4r87I-4s1vD:
undetectable		 4r87I-4s1vD:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 ASN A 384
GLU A 388
GLU A 389
GLU A 385
 None
 1.28A 4r87I-4wikA:
undetectable		 4r87I-4wikA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 GLU A 341
GLU A 338
GLU A 337
GLU A  87
 None
 1.13A 4r87I-5c70A:
undetectable		 4r87I-5c70A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 MET A 183
GLU A 161
GLU A 243
GLU A 237
 None
None
None
MG  A 402 ( 2.7A)
 1.15A 4r87I-5dz2A:
undetectable		 4r87I-5dz2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo7 PREDICTED PROTEIN

(Aspergillus
oryzae) 		PF07938
(Fungal_lectin) 		4 ASN A  46
GLU A  37
TYR A  40
GLU A  41
 None
SFU  A 401 (-2.3A)
SFU  A 405 (-3.1A)
None
 1.22A 4r87I-5eo7A:
undetectable		 4r87I-5eo7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewu MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02514
(CobN-Mg_chel) 		4 MET A1281
GLU A1291
GLU A1287
TYR A1286
 None
 1.37A 4r87I-5ewuA:
undetectable		 4r87I-5ewuA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwj HISTONE DEMETHYLASE
JARID1C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN)
PF02928
(zf-C5HC2) 		4 GLU A 467
GLU A 468
TYR A 469
GLU A 466
 None
 1.21A 4r87I-5fwjA:
undetectable		 4r87I-5fwjA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		4 ASN B1254
GLU B1250
GLU B1249
TYR B1252
 None
 1.24A 4r87I-5hzkB:
undetectable		 4r87I-5hzkB:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 ASN A 320
GLU A 377
GLU A 381
GLU A 322
 MAN  A1627 (-3.7A)
MAN  A1625 (-2.8A)
None
MAN  A1626 (-3.7A)
 1.17A 4r87I-5ihrA:
undetectable		 4r87I-5ihrA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpq ES8

(Chaetomium
thermophilum) 		no annotation 4 ASN t 162
GLU t 197
GLU t 195
GLU t 160
 None
 1.33A 4r87I-5jpqt:
undetectable		 4r87I-5jpqt:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ASN A 129
GLU A 130
GLU A 131
GLU A 124
 None
 1.36A 4r87I-5jxrA:
undetectable		 4r87I-5jxrA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ln1 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Saccharomyces
cerevisiae) 		PF13519
(VWA_2) 		4 ASN A  12
GLU A  82
GLU A  14
TYR A  15
 None
 1.33A 4r87I-5ln1A:
undetectable		 4r87I-5ln1A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 ASN A 423
GLU A 122
GLU A 119
GLU A 464
 None
 0.72A 4r87I-5m10A:
undetectable		 4r87I-5m10A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ASN B 431
GLU B 430
GLU B 465
TYR B 464
 None
 1.34A 4r87I-5mkkB:
undetectable		 4r87I-5mkkB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 4 ASN A 165
GLU A 157
GLU A 160
GLU A 164
 None
 1.10A 4r87I-5nnyA:
undetectable		 4r87I-5nnyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 ASN A 637
GLU A 629
GLU A 178
TYR A 177
 None
 0.94A 4r87I-5nqdA:
undetectable		 4r87I-5nqdA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 MET A 633
GLU A 629
GLU A 178
TYR A 177
 None
 1.35A 4r87I-5nqdA:
undetectable		 4r87I-5nqdA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx3 AMYLOID-BETA A4
PROTEIN

(Homo sapiens) 		no annotation 4 MET D  52
GLU D  48
TYR D  22
GLU D  27
 None
 1.33A 4r87I-5nx3D:
undetectable		 4r87I-5nx3D:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2

(Homo sapiens) 		no annotation 4 ASN B 373
GLU B 375
GLU B 492
TYR B 272
 None
 1.37A 4r87I-5ofbB:
undetectable		 4r87I-5ofbB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		4 GLU A 343
GLU A 344
GLU A 336
GLU A  72
 None
 1.23A 4r87I-5ti8A:
undetectable		 4r87I-5ti8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu9 ACCUMULATION
ASSOCIATED PROTEIN
AAP G58-SPACER-G513
(VARIANT
G5-SPACER-CONSENSUS
G5)

(Staphylococcus
epidermidis) 		PF07501
(G5)
PF17041
(SasG_E) 		4 ASN A  21
GLU A  28
GLU A  29
GLU A  75
 None
 1.04A 4r87I-5tu9A:
undetectable		 4r87I-5tu9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		4 ASN A1106
GLU A1066
GLU A 955
GLU A 931
 None
 1.32A 4r87I-5tuyA:
undetectable		 4r87I-5tuyA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		4 ASN A  87
GLU A  99
GLU A  97
GLU A  89
 None
 1.25A 4r87I-5xeiA:
undetectable		 4r87I-5xeiA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 4 ASN A 296
GLU A 293
GLU A 294
GLU A 292
 None
 1.23A 4r87I-6ceyA:
undetectable		 4r87I-6ceyA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ASN A 328
GLU A 325
GLU A 326
GLU A 372
 None
 1.19A 4r87I-6ewjA:
undetectable		 4r87I-6ewjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 4 GLU B 115
GLU B 111
TYR B 116
GLU B 113
 None
 1.30A 4r87I-6f3mB:
undetectable		 4r87I-6f3mB:
undetectable