SIMILAR PATTERNS OF AMINO ACIDS FOR 4R87_H_SPMH202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ASN A 719
GLU A 782
TYR A 778
GLU A 777
 None
 1.01A 4r87H-1c7tA:
0.0		 4r87H-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ci5 PROTEIN (LYMPHOCYTE
FUNCTION-ASSOCIATED
ANTIGEN 3(CD58))

(Homo sapiens) 		no annotation 4 ASN A  40
GLU A  42
GLU A  39
GLU A  37
 None
 1.47A 4r87H-1ci5A:
undetectable		 4r87H-1ci5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1doi 2FE-2S FERREDOXIN

(Haloarcula
marismortui) 		PF00111
(Fer2) 		4 ASN A 116
GLU A   9
TYR A   5
GLU A  35
 None
 1.37A 4r87H-1doiA:
0.0		 4r87H-1doiA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		4 MET A 232
TYR A 239
GLU A 240
GLU A 245
 None
 1.26A 4r87H-1e08A:
undetectable		 4r87H-1e08A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9n ARGININE
REPRESSOR/ACTIVATOR
PROTEIN

(Bacillus
subtilis) 		PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C) 		4 ASN A  17
GLU A  18
TYR A  62
GLU A  24
 None
 1.24A 4r87H-1f9nA:
undetectable		 4r87H-1f9nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibq ASPERGILLOPEPSIN

(Aspergillus
phoenicis) 		PF00026
(Asp) 		4 ASN A 117
GLU A 110
GLU A  15
GLU A  14
 None
 0.89A 4r87H-1ibqA:
undetectable		 4r87H-1ibqA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		4 ASN B 451
TYR B 452
GLU B 453
GLU B 455
 None
 1.47A 4r87H-1jmuB:
0.0		 4r87H-1jmuB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 MET L 622
GLU L 626
GLU L 633
GLU L 632
 None
 1.42A 4r87H-1kfuL:
0.0		 4r87H-1kfuL:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		4 ASN A 223
GLU A 117
TYR A 111
GLU A 114
 None
 1.46A 4r87H-1ru3A:
0.8		 4r87H-1ru3A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu7 HISTIDYL-TRNA
SYNTHETASE

(Thermoplasma
acidophilum) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 ASN A 163
MET A 168
TYR A 270
GLU A 276
 None
 1.37A 4r87H-1wu7A:
undetectable		 4r87H-1wu7A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z27 OOKINETE SURFACE
PROTEIN PVS25

(Plasmodium
vivax) 		PF06247
(Plasmod_Pvs28) 		4 ASN A  40
GLU A  41
TYR A  69
GLU A  45
 None
 1.09A 4r87H-1z27A:
undetectable		 4r87H-1z27A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl9 GLUTATHIONE
S-TRANSFERASE 5

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASN A  32
GLU A  57
TYR A  29
GLU A  30
 None
 1.23A 4r87H-1zl9A:
undetectable		 4r87H-1zl9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i52 HYPOTHETICAL PROTEIN

(Picrophilus
torridus) 		PF04038
(DHNA) 		4 ASN A  61
MET A  54
GLU A  50
GLU A  89
 None
 1.40A 4r87H-2i52A:
undetectable		 4r87H-2i52A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jaq DEOXYGUANOSINE
KINASE

(Mycoplasma
mycoides) 		PF01712
(dNK) 		4 ASN A  36
MET A  57
GLU A  31
GLU A  34
 None
DCP  A1202 ( 4.2A)
None
None
 1.35A 4r87H-2jaqA:
undetectable		 4r87H-2jaqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krr NUCLEOLIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLU A  90
TYR A 164
GLU A 140
GLU A 144
 None
 1.40A 4r87H-2krrA:
undetectable		 4r87H-2krrA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1

(Saccharomyces
cerevisiae;
synthetic
construct) 		PF13499
(EF-hand_7) 		4 ASN A 460
GLU A  14
GLU A  11
GLU A   7
 None
 1.48A 4r87H-2lhiA:
undetectable		 4r87H-2lhiA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5k ARGININE REPRESSOR

(Bacillus
subtilis) 		PF01316
(Arg_repressor) 		4 ASN A  17
GLU A  18
TYR A  62
GLU A  24
 None
 1.01A 4r87H-2p5kA:
undetectable		 4r87H-2p5kA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		4 ASN A  34
MET A  36
TYR A 132
GLU A 130
 None
 1.37A 4r87H-2wsmA:
undetectable		 4r87H-2wsmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 ASN A 864
GLU A 831
TYR A 865
GLU A 829
 None
 1.46A 4r87H-2x2iA:
undetectable		 4r87H-2x2iA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvx MG2+ TRANSPORTER
MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF01769
(MgtE)
PF03448
(MgtE_N) 		4 GLU A 131
TYR A 129
GLU A 130
GLU A 133
 None
 1.39A 4r87H-2yvxA:
undetectable		 4r87H-2yvxA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		4 ASN A  97
GLU A 115
TYR A 138
GLU A  99
 NAP  A2001 (-3.3A)
None
None
None
 1.12A 4r87H-2yyyA:
undetectable		 4r87H-2yyyA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehe UDP-GLUCOSE
4-EPIMERASE (GALE-1)

(Archaeoglobus
fulgidus) 		PF01370
(Epimerase) 		4 ASN A 287
GLU A 289
TYR A 206
GLU A 290
 None
 1.43A 4r87H-3eheA:
undetectable		 4r87H-3eheA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ASN A 491
GLU A 488
TYR A 486
GLU A 105
 None
 1.45A 4r87H-3fr8A:
undetectable		 4r87H-3fr8A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		4 ASN M 220
GLU M 114
TYR M 108
GLU M 111
 None
 1.42A 4r87H-3i04M:
undetectable		 4r87H-3i04M:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyc PUTATIVE PECTINASE

(Parabacteroides
distasonis) 		PF10988
(DUF2807) 		4 ASN A 177
GLU A 175
GLU A 196
GLU A 216
 None
 1.36A 4r87H-3lycA:
undetectable		 4r87H-3lycA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A 212
GLU A 235
TYR A 240
GLU A 261
 None
MG  A 400 (-2.8A)
None
MG  A 400 ( 4.0A)
 1.46A 4r87H-3mwcA:
1.6		 4r87H-3mwcA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		4 GLU A 215
TYR A 218
GLU A 217
GLU A 286
 ADP  A4001 (-2.4A)
None
P3S  A3001 ( 3.2A)
MG  A2001 ( 2.8A)
 1.33A 4r87H-3o6xA:
undetectable		 4r87H-3o6xA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz7 PHOSPHOGLYCERATE
KINASE

(Plasmodium
falciparum) 		PF00162
(PGK) 		4 ASN A 356
GLU A 360
TYR A 323
GLU A 353
 None
 1.22A 4r87H-3oz7A:
undetectable		 4r87H-3oz7A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK

(Escherichia
coli) 		PF06977
(SdiA-regulated) 		4 ASN A 114
GLU A 310
GLU A 141
GLU A 192
 None
CA  A 325 ( 4.9A)
CA  A 325 ( 2.4A)
CA  A 326 (-2.2A)
 1.25A 4r87H-3qqzA:
undetectable		 4r87H-3qqzA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY

(Francisella
philomiragia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A 194
GLU A 220
TYR A 225
GLU A 246
 MG  A 382 ( 4.7A)
MG  A 382 (-2.9A)
GOL  A 383 (-4.8A)
MG  A 382 ( 3.9A)
 1.32A 4r87H-3r11A:
1.5		 4r87H-3r11A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		4 ASN A  59
MET A 380
GLU A 381
GLU A 187
 None
 1.29A 4r87H-3vw5A:
undetectable		 4r87H-3vw5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		4 GLU A  21
TYR A  23
GLU A 167
GLU A 168
 None
 1.30A 4r87H-3w08A:
undetectable		 4r87H-3w08A:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		5 MET A  28
GLU A  33
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.73A 4r87H-3wr7A:
28.1		 4r87H-3wr7A:
57.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE

(Brevibacillus
brevis) 		PF03306
(AAL_decarboxy) 		4 ASN A 210
MET A 141
GLU A 168
GLU A 166
 None
 1.47A 4r87H-4bt6A:
undetectable		 4r87H-4bt6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		4 ASN A  45
MET A 556
GLU A 552
GLU A  34
 None
 1.50A 4r87H-4c3oA:
undetectable		 4r87H-4c3oA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eba MRNA
3'-END-PROCESSING
PROTEIN RNA14

(Kluyveromyces
lactis) 		PF05843
(Suf) 		4 ASN A 457
MET A 423
TYR A 459
GLU A 461
 None
 1.40A 4r87H-4ebaA:
undetectable		 4r87H-4ebaA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h62 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Saccharomyces
cerevisiae) 		PF10156
(Med17) 		4 MET Q 411
GLU Q 408
GLU Q 477
GLU Q 475
 None
 1.37A 4r87H-4h62Q:
undetectable		 4r87H-4h62Q:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iab HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF14869
(DUF4488) 		4 ASN A  93
GLU A 118
TYR A  95
GLU A 116
 None
 1.48A 4r87H-4iabA:
undetectable		 4r87H-4iabA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		6 ASN A  22
MET A  28
GLU A  33
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.72A 4r87H-4mi4A:
29.8		 4r87H-4mi4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnu SLYA-LIKE
TRANSCRIPTION
REGULATOR

(Listeria
monocytogenes) 		PF01047
(MarR) 		4 ASN A 105
TYR A 107
GLU A 104
GLU A  22
 None
 1.06A 4r87H-4mnuA:
undetectable		 4r87H-4mnuA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 ASN A1558
GLU A1029
TYR A1562
GLU A1559
 None
 1.37A 4r87H-4r04A:
undetectable		 4r87H-4r04A:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 GLU A 361
TYR A 344
GLU A 359
GLU A 316
 None
 1.28A 4r87H-5dl5A:
undetectable		 4r87H-5dl5A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl8 BENZOATE TRANSPORT
PORIN BENP

(Acinetobacter
baumannii) 		no annotation 4 GLU B 345
TYR B 329
GLU B 343
GLU B 303
 None
 1.15A 4r87H-5dl8B:
undetectable		 4r87H-5dl8B:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz2 GERMACRADIENOL/GEOSM
IN SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 MET A 183
GLU A 161
GLU A 243
GLU A 237
 None
None
None
MG  A 402 ( 2.7A)
 1.28A 4r87H-5dz2A:
undetectable		 4r87H-5dz2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		4 ASN A  88
GLU A  91
TYR A  86
GLU A  84
 None
 1.46A 4r87H-5j7xA:
undetectable		 4r87H-5j7xA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 ASN A 190
GLU A 528
TYR A 192
GLU A 227
 None
 1.40A 4r87H-5jxlA:
undetectable		 4r87H-5jxlA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfm CADHERIN-23

(Homo sapiens) 		no annotation 4 ASN A 550
GLU A 551
TYR A 606
GLU A 641
 CA  A 903 ( 3.8A)
None
None
None
 1.36A 4r87H-5tfmA:
undetectable		 4r87H-5tfmA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		4 ASN A 485
TYR A 489
GLU A 525
GLU A 528
 None
 1.20A 4r87H-5wveA:
undetectable		 4r87H-5wveA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		4 ASN A 543
GLU A 546
TYR A 577
GLU A 572
 None
 1.36A 4r87H-5wveA:
undetectable		 4r87H-5wveA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
yayanosii) 		PF02463
(SMC_N) 		4 MET A 154
TYR A 140
GLU A 138
GLU A 165
 None
 1.40A 4r87H-5xeiA:
undetectable		 4r87H-5xeiA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 ASN A 606
GLU A 603
TYR A 601
GLU A 544
 None
None
C  B  33 ( 3.8A)
None
 1.38A 4r87H-5xwyA:
undetectable		 4r87H-5xwyA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 ASN A 934
GLU A 936
TYR A 938
GLU A 937
 None
 1.29A 4r87H-5xwyA:
undetectable		 4r87H-5xwyA:
10.08