SIMILAR PATTERNS OF AMINO ACIDS FOR 4R87_G_SPMG202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		5 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
 None
 1.32A 4r87E-1c7tA:
0.0
4r87G-1c7tA:
0.0		 4r87E-1c7tA:
11.10
4r87G-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		5 ASN A 181
ARG A  87
ASN A 363
GLU A 323
GLU A  53
 None
None
None
EDO  A1396 (-4.4A)
None
 1.32A 4r87E-2jepA:
0.0
4r87G-2jepA:
0.0		 4r87E-2jepA:
22.41
4r87G-2jepA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		6 MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 None
SPD  A 201 (-3.9A)
SPD  A 201 (-4.0A)
SPD  A 201 (-4.6A)
None
SPD  A 201 (-3.1A)
 0.73A 4r87E-3wr7A:
28.3
4r87G-3wr7A:
28.6		 4r87E-3wr7A:
57.06
4r87G-3wr7A:
57.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mi4 SPERMIDINE
N1-ACETYLTRANSFERASE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		7 ASN A  22
MET A  28
GLU A  33
GLU A  34
TYR A  36
GLU A  37
GLU A  41
 SPM  A 201 (-3.7A)
SPM  A 201 ( 4.5A)
SPM  A 201 (-3.2A)
SPM  A 201 (-4.1A)
SPM  A 201 (-4.7A)
SPM  A 201 (-3.5A)
SPM  A 201 (-2.8A)
 0.49A 4r87E-4mi4A:
29.8
4r87G-4mi4A:
30.3		 4r87E-4mi4A:
100.00
4r87G-4mi4A:
100.00