SIMILAR PATTERNS OF AMINO ACIDS FOR 4R82_A_ACTA207

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 GLU A 159
GLY A 157
HIS A 152
ARG A  43
 None
 1.15A 4r82A-1d6sA:
0.0
4r82B-1d6sA:
0.0		 4r82A-1d6sA:
19.63
4r82B-1d6sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		4 GLU A 180
GLY A  65
HIS A  62
ARG A  86
 FMB  A 270 (-4.6A)
None
None
SO4  A 250 ( 3.1A)
 1.41A 4r82A-1jdzA:
0.0
4r82B-1jdzA:
0.0		 4r82A-1jdzA:
24.19
4r82B-1jdzA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkk HUMAN P56 TYROSINE
KINASE

(Homo sapiens) 		PF00017
(SH2) 		4 GLU A 176
GLY A 175
HIS A 148
ARG A 168
 None
 1.06A 4r82A-1lkkA:
0.0
4r82B-1lkkA:
undetectable		 4r82A-1lkkA:
21.62
4r82B-1lkkA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		4 GLU A 215
GLY A  95
HIS A  98
ARG A 102
 None
 1.44A 4r82A-2gzmA:
0.0
4r82B-2gzmA:
0.0		 4r82A-2gzmA:
21.67
4r82B-2gzmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 GLU A 164
GLY A 162
HIS A 157
ARG A  48
 None
 1.24A 4r82A-2isqA:
0.0
4r82B-2isqA:
0.0		 4r82A-2isqA:
21.30
4r82B-2isqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 GLU A 459
GLY A 597
HIS A 698
ARG A 723
 None
 1.31A 4r82A-2rdyA:
0.0
4r82B-2rdyA:
0.0		 4r82A-2rdyA:
14.20
4r82B-2rdyA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		4 GLU A  98
GLY A 190
HIS A 193
ARG A 166
 None
 1.43A 4r82A-3a27A:
0.0
4r82B-3a27A:
0.0		 4r82A-3a27A:
19.71
4r82B-3a27A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 GLU X 366
GLY X 362
HIS X 351
ARG X 349
 None
G  B1846 ( 3.8A)
None
None
 1.37A 4r82A-3j8gX:
0.0
4r82B-3j8gX:
0.0		 4r82A-3j8gX:
19.08
4r82B-3j8gX:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 GLU A 271
GLY A 269
HIS A 171
ARG A 226
 None
None
CL  A 387 (-4.6A)
CL  A 387 (-3.9A)
 1.46A 4r82A-3k2kA:
0.0
4r82B-3k2kA:
0.0		 4r82A-3k2kA:
18.95
4r82B-3k2kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfw UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF07848
(PaaX)
PF08223
(PaaX_C) 		4 GLU X 118
GLY X 117
HIS X 112
ARG X 108
 None
 1.12A 4r82A-3kfwX:
undetectable
4r82B-3kfwX:
undetectable		 4r82A-3kfwX:
25.49
4r82B-3kfwX:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnt 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Burkholderia
pseudomallei) 		PF00300
(His_Phos_1) 		4 GLU A  30
GLY A  32
HIS A  67
ARG A  37
 None
None
EDO  A 251 (-3.5A)
None
 1.01A 4r82A-3lntA:
undetectable
4r82B-3lntA:
undetectable		 4r82A-3lntA:
24.90
4r82B-3lntA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(marine
actinobacterium
PHSC20C1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  64
GLY A  63
HIS A  56
ARG A  54
 None
 1.25A 4r82A-3msyA:
undetectable
4r82B-3msyA:
undetectable		 4r82A-3msyA:
19.89
4r82B-3msyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 GLU B 432
GLY B 433
HIS B 378
ARG B 377
 None
 1.48A 4r82A-3opyB:
undetectable
4r82B-3opyB:
undetectable		 4r82A-3opyB:
11.75
4r82B-3opyB:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q54 OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Escherichia
coli) 		PF13360
(PQQ_2) 		4 GLU A 343
GLY A 344
HIS A 347
ARG A 325
 None
 0.77A 4r82A-3q54A:
undetectable
4r82B-3q54A:
undetectable		 4r82A-3q54A:
21.64
4r82B-3q54A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2y SULFIDE-QUINONE
REDUCTASE, PUTATIVE

(Acidithiobacillus
ferrooxidans) 		PF07992
(Pyr_redox_2) 		4 GLU A 139
GLY A 122
HIS A 120
ARG A 135
 None
 1.36A 4r82A-3t2yA:
undetectable
4r82B-3t2yA:
undetectable		 4r82A-3t2yA:
17.51
4r82B-3t2yA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		4 GLU A 169
GLY A 167
HIS A 162
ARG A  53
 None
 1.20A 4r82A-3tbhA:
undetectable
4r82B-3tbhA:
undetectable		 4r82A-3tbhA:
21.71
4r82B-3tbhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaj ENVELOPE PROTEIN

(Dengue virus) 		no annotation 4 GLU B 368
GLY B 318
HIS B 317
ARG B   9
 None
 1.42A 4r82A-3uajB:
undetectable
4r82B-3uajB:
undetectable		 4r82A-3uajB:
16.86
4r82B-3uajB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		4 GLU A 483
GLY A1049
HIS A1071
ARG A1046
 None
 1.47A 4r82A-3ummA:
undetectable
4r82B-3ummA:
undetectable		 4r82A-3ummA:
10.22
4r82B-3ummA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 GLU A 563
GLY A 636
HIS A 423
ARG A 730
 None
 1.41A 4r82A-3ux1A:
undetectable
4r82B-3ux1A:
undetectable		 4r82A-3ux1A:
16.18
4r82B-3ux1A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 GLU A 322
GLY A 418
HIS A 494
ARG A 488
 None
VO4  A 600 ( 4.8A)
VO4  A 600 (-3.4A)
VO4  A 600 (-4.0A)
 1.19A 4r82A-3w36A:
undetectable
4r82B-3w36A:
undetectable		 4r82A-3w36A:
16.98
4r82B-3w36A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wla OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Sphingopyxis
sp. 113P3) 		no annotation 4 GLU A 235
GLY A 234
HIS A 328
ARG A 252
 None
 1.20A 4r82A-3wlaA:
undetectable
4r82B-3wlaA:
undetectable		 4r82A-3wlaA:
20.61
4r82B-3wlaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 GLU A 272
GLY A 270
HIS A 265
ARG A 156
 None
 1.18A 4r82A-4aecA:
undetectable
4r82B-4aecA:
undetectable		 4r82A-4aecA:
19.19
4r82B-4aecA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		4 GLU A 271
GLY A 269
HIS A 171
ARG A 226
 None
None
ZN  A 385 ( 3.2A)
ACT  A1387 (-2.8A)
 1.49A 4r82A-4b6zA:
undetectable
4r82B-4b6zA:
undetectable		 4r82A-4b6zA:
18.32
4r82B-4b6zA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLU A 614
GLY A 612
HIS A 593
ARG A 592
 None
 1.34A 4r82A-4f0iA:
undetectable
4r82B-4f0iA:
undetectable		 4r82A-4f0iA:
19.00
4r82B-4f0iA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Yersinia pestis) 		PF00005
(ABC_tran) 		4 GLU C 146
GLY C 144
HIS C 182
ARG C 149
 None
 1.25A 4r82A-4g1uC:
undetectable
4r82B-4g1uC:
undetectable		 4r82A-4g1uC:
20.22
4r82B-4g1uC:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575) 		PF00201
(UDPGT)
PF06722
(DUF1205) 		4 GLU A 115
GLY A  12
HIS A 295
ARG A 138
 None
TYD  A 401 ( 3.7A)
None
None
 1.08A 4r82A-4g2tA:
undetectable
4r82B-4g2tA:
undetectable		 4r82A-4g2tA:
19.65
4r82B-4g2tA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 GLU A 180
GLY A 507
HIS A 440
ARG A 441
 None
 1.24A 4r82A-4h1sA:
undetectable
4r82B-4h1sA:
undetectable		 4r82A-4h1sA:
16.05
4r82B-4h1sA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Pseudomonas
aeruginosa) 		PF13360
(PQQ_2) 		4 GLU A 330
GLY A 331
HIS A 334
ARG A 312
 None
 0.75A 4r82A-4hdjA:
undetectable
4r82B-4hdjA:
undetectable		 4r82A-4hdjA:
21.74
4r82B-4hdjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7i RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 GLU A 248
GLY A 250
HIS A 255
ARG A 257
 None
 0.82A 4r82A-4i7iA:
undetectable
4r82B-4i7iA:
undetectable		 4r82A-4i7iA:
16.74
4r82B-4i7iA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jed GLUTATHIONE
S-TRANSFERASE

(Methylobacterium
radiotolerans) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 GLU A 136
GLY A 137
HIS A 184
ARG A 183
 None
 1.50A 4r82A-4jedA:
undetectable
4r82B-4jedA:
undetectable		 4r82A-4jedA:
25.45
4r82B-4jedA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		4 GLU X 160
GLY X 158
HIS X 153
ARG X  44
 None
 1.19A 4r82A-4li3X:
undetectable
4r82B-4li3X:
undetectable		 4r82A-4li3X:
21.45
4r82B-4li3X:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		4 GLU A 163
GLY A 161
HIS A 156
ARG A  45
 None
 1.22A 4r82A-4ofxA:
undetectable
4r82B-4ofxA:
undetectable		 4r82A-4ofxA:
20.50
4r82B-4ofxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		4 GLU A1343
GLY A1344
HIS A1347
ARG A1325
 None
 0.85A 4r82A-4pk1A:
undetectable
4r82B-4pk1A:
undetectable		 4r82A-4pk1A:
13.84
4r82B-4pk1A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 GLU A 152
GLY A 149
HIS A 178
ARG A 140
 None
 1.46A 4r82A-4rnxA:
undetectable
4r82B-4rnxA:
undetectable		 4r82A-4rnxA:
18.95
4r82B-4rnxA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoz BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 GLU A 164
GLY A 166
HIS A 168
ARG A 125
 GLA  A 701 (-3.1A)
None
None
GLA  A 701 (-2.7A)
 1.34A 4r82A-4uozA:
undetectable
4r82B-4uozA:
undetectable		 4r82A-4uozA:
14.88
4r82B-4uozA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 GLU A 161
GLY A 163
HIS A 165
ARG A 122
 GOL  A 702 (-3.0A)
None
None
GOL  A 702 (-2.8A)
 1.28A 4r82A-4uzsA:
undetectable
4r82B-4uzsA:
undetectable		 4r82A-4uzsA:
15.46
4r82B-4uzsA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd4 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 GLU A 125
GLY A 122
HIS A 132
ARG A 117
 None
 1.50A 4r82A-4wd4A:
undetectable
4r82B-4wd4A:
undetectable		 4r82A-4wd4A:
17.91
4r82B-4wd4A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Burkholderia
cenocepacia) 		PF00005
(ABC_tran) 		4 GLU C 150
GLY C 148
HIS C 190
ARG C 153
 None
 1.28A 4r82A-5b57C:
undetectable
4r82B-5b57C:
undetectable		 4r82A-5b57C:
22.63
4r82B-5b57C:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 GLU A 638
GLY A 635
HIS A 924
ARG A 928
 None
 1.43A 4r82A-5h42A:
undetectable
4r82B-5h42A:
undetectable		 4r82A-5h42A:
10.28
4r82B-5h42A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 4 GLU B 155
GLY B 138
HIS B 100
ARG B 136
 None
 1.36A 4r82A-5hdfB:
undetectable
4r82B-5hdfB:
undetectable		 4r82A-5hdfB:
21.37
4r82B-5hdfB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxf 3C PROTEASE

(Enterovirus A) 		PF00548
(Peptidase_C3) 		4 GLU A  66
GLY A  68
HIS A 134
ARG A 135
 None
 1.08A 4r82A-5hxfA:
2.7
4r82B-5hxfA:
2.8		 4r82A-5hxfA:
21.13
4r82B-5hxfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4p NADPH DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 303
GLY A 300
HIS A 329
ARG A 291
 None
 1.35A 4r82A-5v4pA:
undetectable
4r82B-5v4pA:
undetectable		 4r82A-5v4pA:
undetectable
4r82B-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		4 GLU A 160
GLY A 158
HIS A 153
ARG A  46
 None
 1.17A 4r82A-5xa2A:
undetectable
4r82B-5xa2A:
undetectable		 4r82A-5xa2A:
21.54
4r82B-5xa2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 GLU A 271
GLY A 267
HIS A 259
ARG A 148
 None
 1.32A 4r82A-5za2A:
undetectable
4r82B-5za2A:
undetectable		 4r82A-5za2A:
undetectable
4r82B-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A 174
GLY A 172
HIS A 167
ARG A  55
 None
 1.21A 4r82A-6c2hA:
undetectable
4r82B-6c2hA:
undetectable		 4r82A-6c2hA:
undetectable
4r82B-6c2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dft


(;
) 		no annotation
no annotation 		4 GLU A 331
GLY A 327
HIS B 266
ARG B 270
 None
None
NAD  A 502 (-3.6A)
None
 1.49A 4r82A-6dftA:
undetectable
4r82B-6dftA:
undetectable		 4r82A-6dftA:
undetectable
4r82B-6dftA:
undetectable