SIMILAR PATTERNS OF AMINO ACIDS FOR 4R82_A_ACTA205
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1arl | APO-CARBOXYPEPTIDASEA=ALPHA= (COX) (Bos taurus) |
PF00246(Peptidase_M14) | 4 | SER A 41GLY A 44ARG A 45GLU A 43 | None | 1.25A | 4r82A-1arlA:0.04r82B-1arlA:0.0 | 4r82A-1arlA:22.774r82B-1arlA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3r | HDLP (HISTONEDEACETYLASE-LIKEPROTEIN) (Aquifexaeolicus) |
PF00850(Hist_deacetyl) | 4 | SER A 314GLY A 315ARG A 316GLU A 45 | None | 1.32A | 4r82A-1c3rA:0.04r82B-1c3rA:0.0 | 4r82A-1c3rA:18.454r82B-1c3rA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ei7 | COAT PROTEIN (Tobacco mosaicvirus) |
PF00721(TMV_coat) | 4 | SER A 148GLY A 149GLU A 145PHE A 144 | None | 1.30A | 4r82A-1ei7A:undetectable4r82B-1ei7A:undetectable | 4r82A-1ei7A:20.204r82B-1ei7A:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h0h | FORMATEDEHYDROGENASESUBUNIT ALPHA (Desulfovibriogigas) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 4 | SER A 825ARG A 331GLU A 810PHE A 279 | None | 1.26A | 4r82A-1h0hA:0.04r82B-1h0hA:0.0 | 4r82A-1h0hA:12.714r82B-1h0hA:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iqc | DI-HEME PEROXIDASE (Nitrosomonaseuropaea) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 4 | SER A 181ARG A 265GLU A 271PHE A 267 | NoneNoneNoneHEM A 402 (-4.7A) | 0.84A | 4r82A-1iqcA:0.04r82B-1iqcA:0.0 | 4r82A-1iqcA:19.614r82B-1iqcA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iqc | DI-HEME PEROXIDASE (Nitrosomonaseuropaea) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 4 | SER A 181GLY A 180ARG A 265PHE A 267 | NoneNoneNoneHEM A 402 (-4.7A) | 1.06A | 4r82A-1iqcA:0.04r82B-1iqcA:0.0 | 4r82A-1iqcA:19.614r82B-1iqcA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME ALPHASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 4 | SER A 16GLY A 19GLU A 25PHE A 22 | None | 1.31A | 4r82A-1j2qA:0.94r82B-1j2qA:0.8 | 4r82A-1j2qA:22.514r82B-1j2qA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqg | CARBOXYPEPTIDASE A (Helicoverpaarmigera) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 4 | SER A 41GLY A 44ARG A 45GLU A 43 | None | 1.26A | 4r82A-1jqgA:0.04r82B-1jqgA:0.0 | 4r82A-1jqgA:17.624r82B-1jqgA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ku1 | ARFGUANINE-NUCLEOTIDEEXCHANGE FACTOR 2 (Saccharomycescerevisiae) |
PF01369(Sec7) | 4 | SER A 727GLY A 728GLU A 724PHE A 723 | None | 0.81A | 4r82A-1ku1A:undetectable4r82B-1ku1A:undetectable | 4r82A-1ku1A:19.594r82B-1ku1A:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrw | METHANOLDEHYDROGENASESUBUNIT 1METHANOLDEHYDROGENASESUBUNIT 2 (Paracoccusdenitrificans;Paracoccusdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2)PF02315(MDH) | 4 | GLY B 41ARG A 181GLU A 206PHE A 199 | None | 0.91A | 4r82A-1lrwB:undetectable4r82B-1lrwB:undetectable | 4r82A-1lrwB:16.854r82B-1lrwB:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pca | PROCARBOXYPEPTIDASEA PCPA (Sus scrofa) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 4 | SER A 41GLY A 44ARG A 45GLU A 43 | None | 1.28A | 4r82A-1pcaA:0.04r82B-1pcaA:0.0 | 4r82A-1pcaA:18.834r82B-1pcaA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1q | SULFOTRANSFERASEFAMILY, CYTOSOLIC,2B, MEMBER 1 ISOFORMA (Homo sapiens) |
PF00685(Sulfotransfer_1) | 4 | SER A 205GLY A 204ARG A 208GLU A 197 | None | 0.86A | 4r82A-1q1qA:undetectable4r82B-1q1qA:undetectable | 4r82A-1q1qA:19.374r82B-1q1qA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q20 | SULFOTRANSFERASEFAMILY, CYTOSOLIC,2B, MEMBER 1 ISOFORMB (Homo sapiens) |
PF00685(Sulfotransfer_1) | 4 | SER A 220GLY A 219ARG A 223GLU A 212 | None | 0.97A | 4r82A-1q20A:undetectable4r82B-1q20A:undetectable | 4r82A-1q20A:22.484r82B-1q20A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q9c | SON OF SEVENLESSPROTEIN (Homo sapiens) |
PF00125(Histone) | 4 | GLY A 21ARG A 20GLU A 50PHE A 11 | None | 1.17A | 4r82A-1q9cA:undetectable4r82B-1q9cA:undetectable | 4r82A-1q9cA:22.274r82B-1q9cA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qjp | OUTER MEMBRANEPROTEIN A (Escherichiacoli) |
PF01389(OmpA_membrane) | 4 | SER A 167ARG A 138GLU A 52PHE A 40 | None | 1.31A | 4r82A-1qjpA:undetectable4r82B-1qjpA:undetectable | 4r82A-1qjpA:28.174r82B-1qjpA:28.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ryn | PROTEIN CRS2 (Zea mays) |
PF01195(Pept_tRNA_hydro) | 4 | GLY A 138ARG A 21GLU A 158PHE A 154 | GLY A 138 ( 0.0A)ARG A 21 ( 0.6A)GLU A 158 ( 0.6A)PHE A 154 ( 1.3A) | 1.02A | 4r82A-1rynA:undetectable4r82B-1rynA:undetectable | 4r82A-1rynA:24.194r82B-1rynA:24.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfc | PROTEIN (SNAP-25B) (Rattusnorvegicus) |
PF00835(SNAP-25) | 4 | SER D 154GLY D 155GLU D 151PHE D 133 | None | 1.31A | 4r82A-1sfcD:undetectable4r82B-1sfcD:undetectable | 4r82A-1sfcD:19.304r82B-1sfcD:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1te4 | CONSERVED PROTEINMTH187 (Methanothermobacterthermautotrophicus) |
PF13646(HEAT_2) | 4 | SER A 71GLY A 67ARG A 70PHE A 99 | None | 1.05A | 4r82A-1te4A:undetectable4r82B-1te4A:undetectable | 4r82A-1te4A:21.864r82B-1te4A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vp5 | 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE (Thermotogamaritima) |
PF00248(Aldo_ket_red) | 4 | GLY A 194ARG A 195GLU A 193PHE A 269 | NoneNoneNAP A 300 (-3.4A)None | 1.22A | 4r82A-1vp5A:undetectable4r82B-1vp5A:undetectable | 4r82A-1vp5A:21.604r82B-1vp5A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w98 | G1/S-SPECIFIC CYCLINE1 (Homo sapiens) |
PF00134(Cyclin_N)PF02984(Cyclin_C) | 4 | SER B 328GLY B 327ARG B 324PHE B 292 | None | 1.18A | 4r82A-1w98B:undetectable4r82B-1w98B:undetectable | 4r82A-1w98B:19.794r82B-1w98B:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xvt | CROTONOBETAINYL-COA:CARNITINECOA-TRANSFERASE (Escherichiacoli) |
PF02515(CoA_transf_3) | 4 | SER A 20GLY A 21GLU A 94PHE A 92 | COA A 501 ( 4.0A)NoneNoneNone | 1.33A | 4r82A-1xvtA:undetectable4r82B-1xvtA:undetectable | 4r82A-1xvtA:20.344r82B-1xvtA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yle | ARGININEN-SUCCINYLTRANSFERASE, ALPHA CHAIN (Pseudomonasaeruginosa) |
PF04958(AstA) | 4 | SER A 196GLY A 197GLU A 193PHE A 254 | None | 1.29A | 4r82A-1yleA:undetectable4r82B-1yleA:undetectable | 4r82A-1yleA:22.034r82B-1yleA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yvl | SIGNAL TRANSDUCERAND ACTIVATOR OFTRANSCRIPTION1-ALPHA/BETA (Homo sapiens) |
PF00017(SH2)PF01017(STAT_alpha)PF02864(STAT_bind)PF02865(STAT_int) | 4 | SER A 470GLY A 467GLU A 428PHE A 487 | None | 1.07A | 4r82A-1yvlA:undetectable4r82B-1yvlA:undetectable | 4r82A-1yvlA:15.824r82B-1yvlA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfm | THERMOSTABLE DNALIGASE (Pyrococcusfuriosus) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 4 | SER A 469GLY A 470ARG A 526PHE A 524 | None | 1.32A | 4r82A-2cfmA:undetectable4r82B-2cfmA:undetectable | 4r82A-2cfmA:16.274r82B-2cfmA:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cn3 | BETA-1,4-XYLOGLUCANHYDROLASE (Ruminiclostridiumthermocellum) |
PF02012(BNR) | 4 | SER A 159GLY A 157ARG A 158PHE A 51 | NoneNoneXYS A1773 ( 3.3A)None | 1.11A | 4r82A-2cn3A:undetectable4r82B-2cn3A:undetectable | 4r82A-2cn3A:15.184r82B-2cn3A:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7z | ACETYLENE HYDRATASEAHY (Pelobacteracetylenicus) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 4 | SER A 155GLY A 154ARG A 150PHE A 384 | None | 1.17A | 4r82A-2e7zA:undetectable4r82B-2e7zA:undetectable | 4r82A-2e7zA:14.134r82B-2e7zA:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ec5 | DERMONECROTIC TOXIN (Pasteurellamultocida) |
PF11647(MLD) | 4 | SER A 688GLY A 689ARG A 851GLU A 639 | None | 1.32A | 4r82A-2ec5A:undetectable4r82B-2ec5A:undetectable | 4r82A-2ec5A:14.684r82B-2ec5A:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gfi | PHYTASE (Debaryomycescastellii) |
PF00328(His_Phos_2) | 4 | SER A 168GLY A 169ARG A 170GLU A 122 | None | 1.19A | 4r82A-2gfiA:undetectable4r82B-2gfiA:undetectable | 4r82A-2gfiA:17.434r82B-2gfiA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gks | BIFUNCTIONAL SAT/APSKINASE (Aquifexaeolicus) |
PF01583(APS_kinase)PF01747(ATP-sulfurylase)PF14306(PUA_2) | 4 | SER A 130GLY A 36ARG A 33GLU A 93 | None | 1.33A | 4r82A-2gksA:1.74r82B-2gksA:undetectable | 4r82A-2gksA:15.684r82B-2gksA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hqj | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Leishmaniamajor) |
PF00160(Pro_isomerase) | 4 | SER A 120GLY A 119GLU A 83PHE A 74 | None | 1.28A | 4r82A-2hqjA:undetectable4r82B-2hqjA:undetectable | 4r82A-2hqjA:20.834r82B-2hqjA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iip | NICOTINAMIDEN-METHYLTRANSFERASE (Homo sapiens) |
PF01234(NNMT_PNMT_TEMT) | 4 | GLY A 217ARG A 218GLU A 222PHE A 235 | None | 1.24A | 4r82A-2iipA:undetectable4r82B-2iipA:undetectable | 4r82A-2iipA:20.274r82B-2iipA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ip2 | PROBABLEPHENAZINE-SPECIFICMETHYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 4 | GLY A 143ARG A 145GLU A 105PHE A 101 | None | 1.23A | 4r82A-2ip2A:undetectable4r82B-2ip2A:undetectable | 4r82A-2ip2A:20.984r82B-2ip2A:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kjq | DNAA-RELATED PROTEIN (Neisseriameningitidis) |
no annotation | 4 | SER A 113GLY A 114ARG A 109GLU A 85 | None | 1.06A | 4r82A-2kjqA:undetectable4r82B-2kjqA:undetectable | 4r82A-2kjqA:25.624r82B-2kjqA:25.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lri | AUTOIMMUNE REGULATOR (Homo sapiens) |
no annotation | 4 | SER C 57GLY C 58ARG C 54PHE C 40 | None | 0.99A | 4r82A-2lriC:undetectable4r82B-2lriC:undetectable | 4r82A-2lriC:19.574r82B-2lriC:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n1t | SYNAPTOSOMAL-ASSOCIATED PROTEIN 25 (Homo sapiens) |
no annotation | 4 | SER D 154GLY D 155GLU D 151PHE D 133 | None | 1.34A | 4r82A-2n1tD:undetectable4r82B-2n1tD:undetectable | 4r82A-2n1tD:19.444r82B-2n1tD:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nsm | CARBOXYPEPTIDASE NCATALYTIC CHAIN (Homo sapiens) |
PF00246(Peptidase_M14)PF13620(CarboxypepD_reg) | 4 | SER A 34GLY A 37ARG A 38GLU A 36 | None | 1.31A | 4r82A-2nsmA:undetectable4r82B-2nsmA:undetectable | 4r82A-2nsmA:18.104r82B-2nsmA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5p | FERRIPYOVERDINERECEPTOR (Pseudomonasaeruginosa) |
PF00593(TonB_dep_Rec)PF07660(STN)PF07715(Plug) | 4 | GLY A 567ARG A 568GLU A 565PHE A 593 | None | 1.17A | 4r82A-2o5pA:undetectable4r82B-2o5pA:undetectable | 4r82A-2o5pA:14.684r82B-2o5pA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pif | UPF0317 PROTEINPSPTO_5379 (Pseudomonassyringae groupgenomosp. 3) |
PF07286(DUF1445) | 4 | SER A 83GLY A 82ARG A 19PHE A 257 | None | 1.22A | 4r82A-2pifA:undetectable4r82B-2pifA:undetectable | 4r82A-2pifA:24.464r82B-2pifA:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhh | CG3027-PA (Drosophilamelanogaster) |
PF00795(CN_hydrolase) | 4 | SER A 317GLY A 316ARG A 333GLU A 266 | None | 1.22A | 4r82A-2vhhA:undetectable4r82B-2vhhA:undetectable | 4r82A-2vhhA:17.964r82B-2vhhA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2i | PEPTIDYL-TRNAHYDROLASE (Mycobacteriumtuberculosis) |
PF01195(Pept_tRNA_hydro) | 4 | GLY A 138ARG A 21GLU A 158PHE A 154 | None | 0.98A | 4r82A-2z2iA:undetectable4r82B-2z2iA:undetectable | 4r82A-2z2iA:21.054r82B-2z2iA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zgi | PUTATIVE4-AMINO-4-DEOXYCHORISMATE LYASE (Thermusthermophilus) |
PF01063(Aminotran_4) | 4 | GLY A 217ARG A 162GLU A 147PHE A 146 | PLP A 248 (-3.5A)NoneNoneNone | 1.29A | 4r82A-2zgiA:undetectable4r82B-2zgiA:undetectable | 4r82A-2zgiA:21.834r82B-2zgiA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zpa | UNCHARACTERIZEDPROTEIN YPFI (Escherichiacoli) |
PF05127(Helicase_RecD)PF08351(DUF1726)PF13718(GNAT_acetyltr_2)PF17176(tRNA_bind_3) | 4 | SER A 26GLY A 27ARG A 153GLU A 110 | None | 1.06A | 4r82A-2zpaA:undetectable4r82B-2zpaA:undetectable | 4r82A-2zpaA:15.154r82B-2zpaA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asa | LL-DIAMINOPIMELATEAMINOTRANSFERASE (Chlamydiatrachomatis) |
PF00155(Aminotran_1_2) | 4 | SER A 101GLY A 103ARG A 110PHE A 274 | None | 1.29A | 4r82A-3asaA:undetectable4r82B-3asaA:undetectable | 4r82A-3asaA:22.194r82B-3asaA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ceg | BACULOVIRAL IAPREPEAT-CONTAININGPROTEIN 6 (Homo sapiens) |
PF00179(UQ_con) | 4 | GLY A4688ARG A4687GLU A4675PHE A4678 | None | 1.27A | 4r82A-3cegA:undetectable4r82B-3cegA:undetectable | 4r82A-3cegA:20.134r82B-3cegA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e74 | ALLANTOINASE (Escherichiacoli) |
PF01979(Amidohydro_1) | 4 | GLY A 76ARG A 78GLU A 405PHE A 439 | None | 1.24A | 4r82A-3e74A:undetectable4r82B-3e74A:undetectable | 4r82A-3e74A:18.614r82B-3e74A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gfa | PUTATIVENITROREDUCTASE (Clostridioidesdifficile) |
PF00881(Nitroreductase) | 4 | SER A 78GLY A 77GLU A 68PHE A 154 | None | 1.34A | 4r82A-3gfaA:undetectable4r82B-3gfaA:undetectable | 4r82A-3gfaA:20.834r82B-3gfaA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3igr | RIBOSOMAL-PROTEIN-S5-ALANINEN-ACETYLTRANSFERASE (Aliivibriofischeri) |
PF13302(Acetyltransf_3) | 4 | GLY A 111ARG A 115GLU A 8PHE A 7 | None | 1.25A | 4r82A-3igrA:undetectable4r82B-3igrA:undetectable | 4r82A-3igrA:21.944r82B-3igrA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khk | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLATION SUBUNIT (Methanosarcinamazei) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 4 | SER A 389GLY A 388GLU A 420PHE A 441 | None | 1.31A | 4r82A-3khkA:undetectable4r82B-3khkA:undetectable | 4r82A-3khkA:15.354r82B-3khkA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kml | COAT PROTEIN (Tobacco mosaicvirus) |
PF00721(TMV_coat) | 4 | SER A 50GLY A 51GLU A 47PHE A 46 | None | 1.26A | 4r82A-3kmlA:undetectable4r82B-3kmlA:undetectable | 4r82A-3kmlA:19.494r82B-3kmlA:19.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m3i | PUTATIVEUNCHARACTERIZEDPROTEIN (Leishmaniamajor) |
PF06172(Cupin_5) | 4 | SER A 150GLY A 149GLU A 27PHE A 57 | None | 1.08A | 4r82A-3m3iA:undetectable4r82B-3m3iA:undetectable | 4r82A-3m3iA:22.464r82B-3m3iA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nb3 | OUTER MEMBRANEPROTEIN A (Escherichiacoli) |
PF01389(OmpA_membrane) | 4 | SER A 167ARG A 138GLU A 52PHE A 40 | None | 1.31A | 4r82A-3nb3A:undetectable4r82B-3nb3A:undetectable | 4r82A-3nb3A:20.234r82B-3nb3A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ogr | BETA-GALACTOSIDASE (Trichodermareesei) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 4 | SER A 724GLY A 723ARG A 154GLU A 850 | None | 0.96A | 4r82A-3ogrA:undetectable4r82B-3ogrA:undetectable | 4r82A-3ogrA:11.384r82B-3ogrA:11.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qqv | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Corynebacteriumglutamicum) |
PF00348(polyprenyl_synt) | 4 | GLY A 328ARG A 325GLU A 330PHE A 263 | None | 1.33A | 4r82A-3qqvA:undetectable4r82B-3qqvA:undetectable | 4r82A-3qqvA:21.314r82B-3qqvA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sgh | SUSD HOMOLOG (Bacteroidesthetaiotaomicron) |
PF12741(SusD-like) | 4 | SER A 222GLY A 223ARG A 453GLU A 350 | None | 0.97A | 4r82A-3sghA:undetectable4r82B-3sghA:undetectable | 4r82A-3sghA:18.074r82B-3sghA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tt2 | GCN5-RELATEDN-ACETYLTRANSFERASE (Sphaerobacterthermophilus) |
PF00583(Acetyltransf_1) | 4 | SER A 248GLY A 247ARG A 198PHE A 192 | None | 1.24A | 4r82A-3tt2A:undetectable4r82B-3tt2A:undetectable | 4r82A-3tt2A:21.954r82B-3tt2A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttf | TRANSCRIPTIONALREGULATORY PROTEIN (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 4 | SER A 367GLY A 368ARG A 365GLU A 369 | None | 1.28A | 4r82A-3ttfA:undetectable4r82B-3ttfA:undetectable | 4r82A-3ttfA:16.494r82B-3ttfA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpo | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT M2 (Homo sapiens) |
PF00268(Ribonuc_red_sm) | 4 | GLY A 222ARG A 224GLU A 152PHE A 149 | None | 1.03A | 4r82A-3vpoA:undetectable4r82B-3vpoA:undetectable | 4r82A-3vpoA:18.624r82B-3vpoA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vta | CUCUMISIN (Cucumis melo) |
PF00082(Peptidase_S8) | 4 | SER A 363GLY A 364ARG A 365GLU A 398 | None | 1.18A | 4r82A-3vtaA:undetectable4r82B-3vtaA:undetectable | 4r82A-3vtaA:17.784r82B-3vtaA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wz0 | RIBONUCLEASE PPROTEIN COMPONENT 2 (Thermococcuskodakarensis) |
no annotation | 5 | SER C 93GLY C 92ARG C 27GLU C 33PHE C 29 | None | 1.43A | 4r82A-3wz0C:undetectable4r82B-3wz0C:undetectable | 4r82A-3wz0C:23.244r82B-3wz0C:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zxe | GALECTIN-7 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 4 | SER A 63GLY A 70GLU A 73PHE A 109 | None | 1.27A | 4r82A-3zxeA:undetectable4r82B-3zxeA:undetectable | 4r82A-3zxeA:23.664r82B-3zxeA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4byf | UNCONVENTIONALMYOSIN-IC (Homo sapiens) |
PF00063(Myosin_head)PF00612(IQ) | 4 | SER A 104GLY A 105ARG A 589PHE A 414 | None | 1.27A | 4r82A-4byfA:undetectable4r82B-4byfA:undetectable | 4r82A-4byfA:13.144r82B-4byfA:13.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ctd | OUTER MEMBRANEPROTEIN G (Escherichiacoli) |
PF09381(Porin_OmpG) | 4 | SER A 239GLY A 263GLU A 241PHE A 227 | CL A1273 (-3.3A)None CL A1273 (-3.9A)None | 1.28A | 4r82A-4ctdA:undetectable4r82B-4ctdA:undetectable | 4r82A-4ctdA:22.024r82B-4ctdA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d05 | ATP-DEPENDENT DNALIGASE (Psychromonassp. SP041) |
PF01068(DNA_ligase_A_M)PF14743(DNA_ligase_OB_2) | 4 | SER A 76GLY A 77GLU A 73PHE A 72 | None | 1.22A | 4r82A-4d05A:undetectable4r82B-4d05A:undetectable | 4r82A-4d05A:20.744r82B-4d05A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d61 | EUKARYOTIC PEPTIDECHAIN RELEASE FACTORGTP-BINDING SUBUNITERF3A (Homo sapiens) |
PF01201(Ribosomal_S8e) | 4 | SER i 452GLY i 453ARG i 432PHE i 600 | None | 1.29A | 4r82A-4d61i:2.64r82B-4d61i:undetectable | 4r82A-4d61i:18.664r82B-4d61i:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4djn | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASESUBUNIT M2 B (Homo sapiens) |
PF00268(Ribonuc_red_sm) | 4 | GLY A 184ARG A 186GLU A 114PHE A 111 | None | 1.06A | 4r82A-4djnA:undetectable4r82B-4djnA:undetectable | 4r82A-4djnA:18.714r82B-4djnA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dn7 | ABC TRANSPORTER,ATP-BINDING PROTEIN (Methanosarcinamazei) |
PF01458(UPF0051) | 4 | SER A 242GLY A 215ARG A 241GLU A 24 | None | 1.21A | 4r82A-4dn7A:undetectable4r82B-4dn7A:undetectable | 4r82A-4dn7A:19.194r82B-4dn7A:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezi | UNCHARACTERIZEDPROTEIN (Legionellapneumophila) |
no annotation | 4 | GLY A 241ARG A 345GLU A 239PHE A 235 | None | 1.33A | 4r82A-4eziA:undetectable4r82B-4eziA:undetectable | 4r82A-4eziA:19.524r82B-4eziA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqh | CAPSID PROTEIN (Tobacco mosaicvirus) |
PF00721(TMV_coat) | 4 | SER A 148GLY A 149GLU A 145PHE A 144 | None | 1.24A | 4r82A-4gqhA:undetectable4r82B-4gqhA:undetectable | 4r82A-4gqhA:19.804r82B-4gqhA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gys | ALLOPHANATEHYDROLASE (Granulibacterbethesdensis) |
PF01425(Amidase) | 4 | GLY A 448ARG A 451GLU A 444PHE A 411 | None | 1.19A | 4r82A-4gysA:undetectable4r82B-4gysA:undetectable | 4r82A-4gysA:16.924r82B-4gysA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9u | TRK SYSTEM POTASSIUMUPTAKE PROTEIN TRKH (Vibrioparahaemolyticus) |
PF02386(TrkH) | 4 | GLY A 355ARG A 360GLU A 470PHE A 402 | None | 1.23A | 4r82A-4j9uA:undetectable4r82B-4j9uA:undetectable | 4r82A-4j9uA:15.854r82B-4j9uA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kma | GM14141P (Drosophilamelanogaster) |
PF05076(SUFU)PF12470(SUFU_C) | 4 | GLY A 198ARG A 236GLU A 203PHE A 200 | None | 1.33A | 4r82A-4kmaA:undetectable4r82B-4kmaA:undetectable | 4r82A-4kmaA:16.604r82B-4kmaA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kw7 | ARSENICMETHYLTRANSFERASE (Cyanidioschyzonsp. 5508) |
PF13847(Methyltransf_31) | 4 | SER A 331GLY A 196ARG A 332GLU A 198 | None | 1.21A | 4r82A-4kw7A:undetectable4r82B-4kw7A:undetectable | 4r82A-4kw7A:20.274r82B-4kw7A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l6y | PROTEIN REGULATOR OFCYTOKINESIS 1 (Homo sapiens) |
PF03999(MAP65_ASE1) | 4 | SER A 267GLY A 266ARG A 240GLU A 233 | None | 1.30A | 4r82A-4l6yA:undetectable4r82B-4l6yA:undetectable | 4r82A-4l6yA:15.104r82B-4l6yA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lq1 | 1,4-ALPHA-GLUCANBRANCHING ENZYMEGLGB (Escherichiacoli) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 4 | SER A 172GLY A 173ARG A 169GLU A 176 | None | 1.29A | 4r82A-4lq1A:undetectable4r82B-4lq1A:undetectable | 4r82A-4lq1A:16.334r82B-4lq1A:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhc | NUCLEOPORIN NUP157 (Saccharomycescerevisiae) |
PF08801(Nucleoporin_N) | 4 | SER A 642GLY A 711ARG A 718GLU A 639 | None | 1.18A | 4r82A-4mhcA:undetectable4r82B-4mhcA:undetectable | 4r82A-4mhcA:11.944r82B-4mhcA:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nrh | COPN (Chlamydiapneumoniae) |
PF07201(HrpJ) | 4 | SER A 201GLY A 202ARG A 204GLU A 106 | None | 1.33A | 4r82A-4nrhA:undetectable4r82B-4nrhA:undetectable | 4r82A-4nrhA:21.024r82B-4nrhA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q38 | PUTATIVEUNCHARACTERIZEDPROTEIN TCP24 (Actinoplanesteichomyceticus) |
no annotation | 4 | GLY A 87ARG A 129GLU A 226PHE A 224 | None | 1.22A | 4r82A-4q38A:undetectable4r82B-4q38A:undetectable | 4r82A-4q38A:21.044r82B-4q38A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvw | ZNUD (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | SER A 166GLY A 153ARG A 43GLU A 151 | None | 1.30A | 4r82A-4rvwA:undetectable4r82B-4rvwA:undetectable | 4r82A-4rvwA:14.434r82B-4rvwA:14.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uxd | 2-DEHYDRO-3-DEOXY-D-GLUCONATE/2-DEHYDRO-3-DEOXY-PHOSPHOGLUCONATE ALDOLASE (Picrophilustorridus) |
PF00701(DHDPS) | 4 | GLY A 17ARG A 264GLU A 55PHE A 51 | None | 1.01A | 4r82A-4uxdA:undetectable4r82B-4uxdA:undetectable | 4r82A-4uxdA:19.724r82B-4uxdA:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yly | PEPTIDYL-TRNAHYDROLASE (Staphylococcusaureus) |
PF01195(Pept_tRNA_hydro) | 4 | GLY A 134ARG A 18GLU A 154PHE A 150 | None | 0.87A | 4r82A-4ylyA:undetectable4r82B-4ylyA:undetectable | 4r82A-4ylyA:22.614r82B-4ylyA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxi | TYROCIDINESYNTHETASE 3 (Acinetobacterbaumannii) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 4 | SER A 161ARG A 158GLU A 366PHE A 367 | XP4 A1404 ( 4.7A)NoneNoneNone | 1.28A | 4r82A-4zxiA:undetectable4r82B-4zxiA:undetectable | 4r82A-4zxiA:10.264r82B-4zxiA:10.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0k | LABDANE-RELATEDDITERPENE SYNTHASE (Streptomycessp.) |
no annotation | 4 | GLY A 282ARG A 280GLU A 302PHE A 20 | None | 0.95A | 4r82A-5a0kA:undetectable4r82B-5a0kA:undetectable | 4r82A-5a0kA:20.774r82B-5a0kA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aoh | CARF (Serratia sp.ATCC 39006) |
PF03781(FGE-sulfatase) | 4 | SER A 241GLY A 240ARG A 168PHE A 21 | None | 0.84A | 4r82A-5aohA:undetectable4r82B-5aohA:undetectable | 4r82A-5aohA:23.134r82B-5aohA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5djq | CBB3-TYPE CYTOCHROMEC OXIDASE SUBUNITCCON1CBB3-TYPE CYTOCHROMEC OXIDASE SUBUNIT II (Pseudomonasstutzeri;Pseudomonasstutzeri) |
PF00115(COX1)PF02433(FixO) | 4 | SER A 52GLY A 54ARG A 55GLU B 63 | NoneHEC B 301 ( 4.0A)NoneNone | 1.07A | 4r82A-5djqA:undetectable4r82B-5djqA:undetectable | 4r82A-5djqA:18.744r82B-5djqA:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey6 | PHI CLASSGLUTATHIONETRANSFERASE GSTF2 (Populustrichocarpa) |
PF00043(GST_C)PF02798(GST_N) | 4 | SER A 114GLY A 115GLU A 106PHE A 110 | None | 1.32A | 4r82A-5ey6A:undetectable4r82B-5ey6A:undetectable | 4r82A-5ey6A:23.484r82B-5ey6A:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5glg | FUMARATE REDUCTASE 2 (Saccharomycescerevisiae) |
PF00890(FAD_binding_2) | 4 | SER A 481GLY A 479ARG A 153PHE A 101 | NoneSIN A 601 (-3.6A)NoneNone | 1.26A | 4r82A-5glgA:undetectable4r82B-5glgA:undetectable | 4r82A-5glgA:16.344r82B-5glgA:16.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gyy | S-LOCUS PROTEIN 11 (Brassica rapa) |
PF06876(SCRL) | 4 | SER G 12GLY G 13ARG G 48PHE G 27 | None | 0.93A | 4r82A-5gyyG:undetectable4r82B-5gyyG:undetectable | 4r82A-5gyyG:14.054r82B-5gyyG:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h05 | AMYP (marinemetagenome) |
PF00128(Alpha-amylase) | 4 | SER A 137GLY A 140ARG A 141GLU A 139 | None | 1.28A | 4r82A-5h05A:undetectable4r82B-5h05A:undetectable | 4r82A-5h05A:15.324r82B-5h05A:15.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i0p | BETA-LACTAMASEDOMAIN PROTEIN (Burkholderiaambifaria) |
PF00753(Lactamase_B) | 4 | GLY A 113ARG A 114GLU A 75PHE A 78 | None | 1.14A | 4r82A-5i0pA:undetectable4r82B-5i0pA:undetectable | 4r82A-5i0pA:20.914r82B-5i0pA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l6s | GLUCOSE-1-PHOSPHATEADENYLYLTRANSFERASE (Escherichiacoli) |
PF00483(NTP_transferase) | 4 | SER A 352GLY A 336ARG A 353GLU A 311 | None | 0.87A | 4r82A-5l6sA:undetectable4r82B-5l6sA:undetectable | 4r82A-5l6sA:18.164r82B-5l6sA:18.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqx | NON-STRUCTURALPROTEIN3 (Venezuelanequineencephalitisvirus) |
no annotation | 4 | SER A 115GLY A 116ARG A 120GLU A 78 | None | 1.18A | 4r82A-5mqxA:undetectable4r82B-5mqxA:undetectable | 4r82A-5mqxA:undetectable4r82B-5mqxA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nvr | TELOMERE LENGTHREGULATOR PROTEINRIF1 (Saccharomycescerevisiae) |
PF12231(Rif1_N) | 4 | SER A 534GLY A 535ARG A 537GLU A 461 | None | 1.33A | 4r82A-5nvrA:undetectable4r82B-5nvrA:undetectable | 4r82A-5nvrA:9.464r82B-5nvrA:9.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t5i | TUNGSTENFORMYLMETHANOFURANDEHYDROGENASESUBUNIT B (Methanothermobactersp. CaT2) |
PF00384(Molybdopterin) | 4 | GLY B 13ARG B 395GLU B 397PHE B 136 | None | 1.14A | 4r82A-5t5iB:undetectable4r82B-5t5iB:undetectable | 4r82A-5t5iB:18.564r82B-5t5iB:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wze | AMINOPEPTIDASE P (Pseudomonasaeruginosa) |
no annotation | 4 | SER A 231GLY A 230GLU A 216PHE A 219 | None | 1.25A | 4r82A-5wzeA:undetectable4r82B-5wzeA:undetectable | 4r82A-5wzeA:undetectable4r82B-5wzeA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1n | VANILLATE/3-O-METHYLGALLATEO-DEMETHYLASE (Sphingobium sp.SYK-6) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | GLY A 321ARG A 322GLU A 326PHE A 315 | None | 1.09A | 4r82A-5x1nA:undetectable4r82B-5x1nA:undetectable | 4r82A-5x1nA:17.414r82B-5x1nA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2o | TASTE RECEPTOR, TYPE1, MEMBER 3 (Oryzias latipes) |
PF01094(ANF_receptor) | 4 | SER B 169GLY B 171ARG B 188PHE B 186 | NoneARG B 951 (-4.2A)NoneNone | 1.08A | 4r82A-5x2oB:undetectable4r82B-5x2oB:undetectable | 4r82A-5x2oB:18.604r82B-5x2oB:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x2q | TASTE RECEPTOR, TYPE1, MEMBER 2A (Oryzias latipes) |
PF01094(ANF_receptor) | 4 | SER A 161GLY A 163ARG A 180PHE A 178 | NoneGLY A 951 (-4.9A)NoneNone | 1.19A | 4r82A-5x2qA:undetectable4r82B-5x2qA:undetectable | 4r82A-5x2qA:17.324r82B-5x2qA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xu1 | ABC TRANSPORTERPERMEAE (Streptococcuspneumoniae) |
no annotation | 4 | SER M 314ARG M 318GLU M 342PHE M 339 | None | 1.23A | 4r82A-5xu1M:undetectable4r82B-5xu1M:undetectable | 4r82A-5xu1M:undetectable4r82B-5xu1M:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6erc | PEROXINECTIN A (Dictyosteliumdiscoideum) |
no annotation | 4 | GLY A 31ARG A 490GLU A 23PHE A 491 | None | 1.25A | 4r82A-6ercA:undetectable4r82B-6ercA:undetectable | 4r82A-6ercA:undetectable4r82B-6ercA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f79 | - (-) |
no annotation | 4 | SER A 38GLY A 41ARG A 42GLU A 40 | None | 1.28A | 4r82A-6f79A:undetectable4r82B-6f79A:undetectable | 4r82A-6f79A:undetectable4r82B-6f79A:undetectable |