SIMILAR PATTERNS OF AMINO ACIDS FOR 4R7I_A_STIA1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR

(Homo sapiens) 		PF01858
(RB_A) 		4 LEU A 487
VAL A 494
TYR A 446
ARG A 544
 None
 1.12A 4r7iA-1ad6A:
undetectable		 4r7iA-1ad6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fjj HYPOTHETICAL 17.1
KDA PROTEIN IN
MODC-BIOA INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		4 VAL A  65
VAL A 120
TYR A  51
ARG A 127
 None
 1.11A 4r7iA-1fjjA:
undetectable		 4r7iA-1fjjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU B 335
VAL B 162
TYR B 171
ARG B 350
 None
 1.07A 4r7iA-1hr7B:
undetectable		 4r7iA-1hr7B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 VAL S 122
VAL S  86
TYR S 108
ARG S 715
 None
 1.08A 4r7iA-1i84S:
undetectable		 4r7iA-1i84S:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luz PROTEIN K3

(Vaccinia virus) 		PF00575
(S1) 		4 LEU A  58
VAL A  79
VAL A  44
TYR A  81
 None
 0.91A 4r7iA-1luzA:
undetectable		 4r7iA-1luzA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		4 LEU A 253
VAL A 420
TYR A 427
ARG A 374
 None
 0.79A 4r7iA-1q15A:
undetectable		 4r7iA-1q15A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY

(Enterococcus
faecalis) 		PF02567
(PhzC-PhzF) 		4 LEU A 169
VAL A 177
TYR A 129
ARG A 231
 None
 1.13A 4r7iA-1s7jA:
undetectable		 4r7iA-1s7jA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 LEU A 317
VAL A 265
TYR A 261
ARG A 199
 None
 1.10A 4r7iA-1sb8A:
undetectable		 4r7iA-1sb8A:
26.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 595
VAL A 654
VAL A 668
TYR A 672
ARG A 791
 STI  A   3 ( 3.8A)
STI  A   3 (-4.3A)
STI  A   3 (-4.6A)
STI  A   3 ( 4.0A)
None
 0.61A 4r7iA-1t46A:
42.4		 4r7iA-1t46A:
67.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 676
VAL A 586
VAL A 610
TYR A 626
 None
 1.13A 4r7iA-1tkcA:
undetectable		 4r7iA-1tkcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 244
VAL A 399
VAL A 238
TYR A 332
 None
 1.09A 4r7iA-1ulzA:
undetectable		 4r7iA-1ulzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxu PEROXISOMAL
BIOGENESIS FACTOR 13

(Mus musculus) 		PF14604
(SH3_9) 		4 LEU A  61
VAL A  74
VAL A  18
ARG A  54
 None
 1.13A 4r7iA-1wxuA:
undetectable		 4r7iA-1wxuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		4 LEU A  14
VAL A  51
TYR A  44
ARG A 221
 None
None
MET  A 301 (-3.7A)
None
 1.00A 4r7iA-1xs5A:
undetectable		 4r7iA-1xs5A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  68
TYR A  86
ARG A 129
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
 0.64A 4r7iA-1zltA:
14.2		 4r7iA-1zltA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Saccharomyces
cerevisiae) 		PF00977
(His_biosynth) 		4 LEU A 116
VAL A 133
TYR A 171
ARG A 138
 None
 1.13A 4r7iA-2agkA:
undetectable		 4r7iA-2agkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A 256
VAL A 264
VAL A 244
TYR A 293
 None
 1.03A 4r7iA-2avfA:
undetectable		 4r7iA-2avfA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
VAL X  67
TYR X  84
ARG X 129
 STU  X 902 (-3.8A)
None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
 0.69A 4r7iA-2dq7X:
31.6		 4r7iA-2dq7X:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A 288
VAL A 296
VAL A 276
TYR A 325
 None
 1.07A 4r7iA-2dwsA:
undetectable		 4r7iA-2dwsA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 233
VAL A 275
VAL A 270
ARG A 453
 None
 0.98A 4r7iA-2fqdA:
undetectable		 4r7iA-2fqdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE

(Mus musculus) 		PF02485
(Branch) 		4 LEU A 139
VAL A 176
VAL A 154
ARG A  98
 None
 0.84A 4r7iA-2gamA:
undetectable		 4r7iA-2gamA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE

(Mus musculus) 		PF02485
(Branch) 		4 VAL A 176
VAL A 154
TYR A 125
ARG A  98
 None
 1.05A 4r7iA-2gamA:
undetectable		 4r7iA-2gamA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0b NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		4 LEU A 457
VAL A 423
VAL A 331
TYR A 294
 None
 1.11A 4r7iA-2h0bA:
undetectable		 4r7iA-2h0bA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 323
TYR A 340
ARG A 385
 H8H  A 534 (-3.8A)
None
H8H  A 534 (-4.3A)
None
 0.85A 4r7iA-2h8hA:
29.7		 4r7iA-2h8hA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icu HYPOTHETICAL PROTEIN
YEDK

(Escherichia
coli) 		PF02586
(SRAP) 		4 LEU A  97
VAL A  66
TYR A  70
ARG A  31
 None
 1.04A 4r7iA-2icuA:
undetectable		 4r7iA-2icuA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 301
TYR A 318
ARG A 363
 None
None
1N8  A 501 ( 3.7A)
None
 0.95A 4r7iA-2og8A:
31.3		 4r7iA-2og8A:
38.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 588
VAL A 647
VAL A 661
TYR A 665
ARG A 777
 None
 0.50A 4r7iA-2ogvA:
29.1		 4r7iA-2ogvA:
95.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		4 LEU A  36
VAL A  90
VAL A  67
ARG A 246
 None
 1.09A 4r7iA-2olaA:
undetectable		 4r7iA-2olaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 364
VAL A 242
TYR A 255
ARG A 174
 None
 1.11A 4r7iA-2p0uA:
undetectable		 4r7iA-2p0uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbk KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		4 LEU A  56
VAL A  52
TYR A   6
ARG A 142
 None
 1.09A 4r7iA-2pbkA:
undetectable		 4r7iA-2pbkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 LEU A  79
VAL A   6
VAL A  96
TYR A  92
 None
 0.94A 4r7iA-2petA:
undetectable		 4r7iA-2petA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 487
VAL A 562
TYR A 566
ARG A 625
 None
None
None
SO4  A 303 ( 2.9A)
 0.55A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 487
VAL A 562
TYR A 566
ARG A 664
 None
 0.97A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		4 VAL A 644
VAL A 720
TYR A 684
ARG A 660
 None
 0.96A 4r7iA-2r8qA:
undetectable		 4r7iA-2r8qA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 456
VAL A 112
TYR A 429
ARG A 217
 PG4  A1596 (-4.3A)
None
PG4  A1596 (-4.8A)
None
 0.99A 4r7iA-2v6oA:
undetectable		 4r7iA-2v6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 LEU A   9
VAL A 234
VAL A  39
TYR A 244
 None
 1.03A 4r7iA-2yvtA:
undetectable		 4r7iA-2yvtA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1002
VAL A1060
VAL A1074
ARG A1131
 S91  A   1 ( 4.1A)
None
None
PTR  A1163 ( 3.6A)
 0.96A 4r7iA-2z8cA:
30.9		 4r7iA-2z8cA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 487
VAL A 562
TYR A 566
ARG A 625
 M33  A1996 (-4.0A)
None
M33  A1996 ( 4.7A)
None
 0.59A 4r7iA-3b2tA:
33.4		 4r7iA-3b2tA:
45.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE

(Histophilus
somni) 		PF00834
(Ribul_P_3_epim) 		4 LEU A  42
VAL A  57
VAL A  87
ARG A 159
 None
 1.06A 4r7iA-3cu2A:
undetectable		 4r7iA-3cu2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00005
(ABC_tran)
PF03459
(TOBE) 		4 LEU A 151
VAL A  23
TYR A  28
ARG A  56
 None
 1.05A 4r7iA-3d31A:
undetectable		 4r7iA-3d31A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		4 LEU A 292
VAL A 360
TYR A 417
ARG A 491
 None
 1.13A 4r7iA-3dwcA:
undetectable		 4r7iA-3dwcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 VAL A 147
VAL A 156
TYR A 291
ARG A 136
 None
 1.12A 4r7iA-3e82A:
undetectable		 4r7iA-3e82A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 LEU A1045
VAL A1098
TYR A1094
ARG A 866
 None
None
None
CL  A1226 (-4.0A)
 1.11A 4r7iA-3fawA:
undetectable		 4r7iA-3fawA:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 833
VAL A 892
VAL A 907
TYR A 911
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.5A)
8ST  A2001 (-4.9A)
 0.33A 4r7iA-3hngA:
42.0		 4r7iA-3hngA:
44.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 LEU A 471
VAL A 169
VAL A 484
ARG A 363
 None
 1.11A 4r7iA-3hq2A:
undetectable		 4r7iA-3hq2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A  92
VAL A 177
VAL A 139
TYR A 166
 None
 1.09A 4r7iA-3ifrA:
undetectable		 4r7iA-3ifrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		4 LEU A 582
VAL A 545
VAL A 551
TYR A 578
 None
 1.11A 4r7iA-3jbyA:
undetectable		 4r7iA-3jbyA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S17,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S25,
MITOCHONDRIAL

(Bos taurus) 		PF00366
(Ribosomal_S17)
PF14955
(MRP-S24) 		4 LEU Q  40
VAL c  48
TYR c  57
ARG Q  29
 None
 1.11A 4r7iA-3jd5Q:
undetectable		 4r7iA-3jd5Q:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN

(Suregada
multiflora) 		PF00161
(RIP) 		4 LEU A 157
VAL A  54
VAL A  73
TYR A  78
 None
 1.01A 4r7iA-3ku0A:
undetectable		 4r7iA-3ku0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		4 LEU A 104
VAL A  15
VAL A  43
TYR A 102
 None
 1.06A 4r7iA-3kzaA:
undetectable		 4r7iA-3kzaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  49
VAL A 104
TYR A 122
ARG A 165
 XFE  A 351 (-4.2A)
None
None
TPO  A 197 ( 3.1A)
 0.75A 4r7iA-3mvjA:
15.1		 4r7iA-3mvjA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		4 LEU A 318
VAL A 363
VAL A 379
ARG A  32
 None
 0.95A 4r7iA-3nraA:
undetectable		 4r7iA-3nraA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		4 LEU A 139
VAL A  93
VAL A 109
TYR A 220
 None
 0.93A 4r7iA-3o8jA:
undetectable		 4r7iA-3o8jA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		4 LEU A 120
VAL A  31
VAL A  59
TYR A 118
 None
 1.00A 4r7iA-3ph5A:
undetectable		 4r7iA-3ph5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 LEU A 120
VAL A  39
VAL A  58
TYR A 114
 None
 1.03A 4r7iA-3qzbA:
undetectable		 4r7iA-3qzbA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 899
VAL A 914
ARG A1027
 LEV  A1201 ( 3.8A)
None
None
None
 0.51A 4r7iA-3wzdA:
34.8		 4r7iA-3wzdA:
48.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		4 LEU A 171
VAL A 206
VAL A 231
TYR A 227
 None
 0.97A 4r7iA-3zxlA:
undetectable		 4r7iA-3zxlA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
VAL A 114
VAL A 128
ARG A 175
 939  A1331 (-3.7A)
None
None
None
 0.59A 4r7iA-4a4lA:
22.5		 4r7iA-4a4lA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 LEU A 164
VAL A 181
VAL A 204
ARG A 368
 None
 0.96A 4r7iA-4aoaA:
undetectable		 4r7iA-4aoaA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 560
VAL A 617
TYR A 635
ARG A 691
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-4.7A)
None
 1.08A 4r7iA-4at3A:
33.0		 4r7iA-4at3A:
37.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 663
VAL A 721
TYR A 739
ARG A 781
 AGS  A1985 (-4.2A)
None
None
TPO  A 816 ( 3.0A)
 0.72A 4r7iA-4crsA:
20.5		 4r7iA-4crsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		4 LEU A 229
VAL A 268
VAL A 259
TYR A 191
 None
 0.97A 4r7iA-4dimA:
undetectable		 4r7iA-4dimA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 LEU A  16
VAL A  71
TYR A  89
ARG A 132
 ANP  A 300 (-4.7A)
None
ANP  A 300 (-4.3A)
None
 1.07A 4r7iA-4eqmA:
21.4		 4r7iA-4eqmA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk5 DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF16727
(REV1_C) 		4 LEU E1203
VAL E1236
VAL E1250
TYR E1244
 None
 1.01A 4r7iA-4gk5E:
undetectable		 4r7iA-4gk5E:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 855
VAL A 911
TYR A 931
ARG A 975
 IZA  A2001 (-3.7A)
None
None
None
 0.94A 4r7iA-4gl9A:
28.2		 4r7iA-4gl9A:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 LEU C 787
VAL C 819
TYR C 773
ARG C 807
 None
 1.08A 4r7iA-4hb4C:
undetectable		 4r7iA-4hb4C:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Pseudomonas
aeruginosa) 		PF13360
(PQQ_2) 		4 LEU A  32
VAL A 326
VAL A 344
TYR A 332
 None
 1.12A 4r7iA-4hdjA:
undetectable		 4r7iA-4hdjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		4 LEU B 201
VAL B  30
VAL B  87
TYR B  35
 None
 1.12A 4r7iA-4hzuB:
undetectable		 4r7iA-4hzuB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		4 LEU A  45
VAL A 100
VAL A 114
ARG A 161
 None
 0.80A 4r7iA-4j7bA:
22.3		 4r7iA-4j7bA:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 478
VAL A 553
TYR A 557
ARG A 616
 ACP  A 801 (-3.8A)
None
None
None
 0.66A 4r7iA-4k33A:
28.6		 4r7iA-4k33A:
48.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5n URACIL-DNA
GLYCOSYLASE

(Human
alphaherpesvirus
1) 		PF03167
(UDG) 		4 LEU A  99
VAL A  83
TYR A  74
ARG A 167
 None
 1.08A 4r7iA-4l5nA:
undetectable		 4r7iA-4l5nA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 323
TYR A 340
ARG A 385
 VGG  A 601 (-3.2A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
None
 0.75A 4r7iA-4lggA:
28.5		 4r7iA-4lggA:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 LEU A 104
VAL A 118
VAL A 135
TYR A 128
 None
 1.02A 4r7iA-4my5A:
undetectable		 4r7iA-4my5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 627
VAL A 685
TYR A 703
ARG A 745
 None
None
None
TPO  A 780 ( 2.8A)
 0.83A 4r7iA-4otdA:
21.6		 4r7iA-4otdA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 VAL A 816
VAL A  75
TYR A 825
ARG A 940
 None
 1.10A 4r7iA-4q0wA:
undetectable		 4r7iA-4q0wA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q14 5-HYDROXYISOURATE
HYDROLASE

(Brucella
abortus) 		PF00576
(Transthyretin) 		4 LEU A  52
VAL A 103
VAL A  22
TYR A  62
 None
 1.08A 4r7iA-4q14A:
undetectable		 4r7iA-4q14A:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
VAL A  65
TYR A  83
ARG A 128
 ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.5A)
None
 1.02A 4r7iA-4ueuA:
31.4		 4r7iA-4ueuA:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 LEU A  66
VAL A  58
VAL A   4
TYR A 108
 None
None
None
UCA  A 301 (-3.6A)
 1.12A 4r7iA-4w97A:
undetectable		 4r7iA-4w97A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		4 LEU A 104
VAL A 159
TYR A 177
ARG A 220
 ATP  A 501 ( 4.3A)
None
None
TPO  A 252 ( 2.9A)
 0.76A 4r7iA-4wb7A:
15.3		 4r7iA-4wb7A:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
VAL A 675
TYR A 693
ARG A 810
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.4A)
None
 0.81A 4r7iA-4xufA:
30.4		 4r7iA-4xufA:
60.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1y GALECTIN-1

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 LEU A   4
VAL A  87
VAL A  23
ARG A  73
 None
CSO  A  88 ( 3.1A)
None
6S2  A 202 (-3.8A)
 1.10A 4r7iA-4y1yA:
undetectable		 4r7iA-4y1yA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8j VWA2

(Sulfolobus
acidocaldarius) 		PF00092
(VWA) 		4 LEU A   8
VAL A 293
VAL A 242
ARG A 286
 None
None
None
CIT  A1373 (-3.9A)
 1.06A 4r7iA-5a8jA:
undetectable		 4r7iA-5a8jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Paraburkholderia
xenovorans) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LEU A  60
VAL A  95
VAL A  67
ARG A 109
 None
 1.09A 4r7iA-5aewA:
undetectable		 4r7iA-5aewA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5akr COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A 256
VAL A 264
VAL A 244
TYR A 293
 None
 1.05A 4r7iA-5akrA:
undetectable		 4r7iA-5akrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Aeropyrum
pernix) 		PF13561
(adh_short_C2) 		4 LEU A 125
VAL A 180
VAL A  85
TYR A 176
 None
 1.12A 4r7iA-5b1yA:
undetectable		 4r7iA-5b1yA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 LEU A 408
VAL A 206
VAL A 221
TYR A 419
 None
 1.03A 4r7iA-5bn4A:
undetectable		 4r7iA-5bn4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A 427
VAL A 477
TYR A 242
ARG A 459
 None
None
None
SO4  A 601 (-3.6A)
 1.04A 4r7iA-5cwaA:
undetectable		 4r7iA-5cwaA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
VAL A 658
TYR A 676
ARG A 817
 748  A1001 (-3.8A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
None
 0.69A 4r7iA-5grnA:
42.3		 4r7iA-5grnA:
56.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 4 LEU A 489
VAL A 521
VAL A 473
TYR A 469
 None
 1.08A 4r7iA-5h4eA:
undetectable		 4r7iA-5h4eA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		4 LEU A 230
VAL A 188
VAL A 173
ARG A  25
 None
 1.11A 4r7iA-5hr6A:
undetectable		 4r7iA-5hr6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 VAL A 117
VAL A  74
TYR A  81
ARG A 150
 None
 1.10A 4r7iA-5hxaA:
undetectable		 4r7iA-5hxaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 328
VAL A 342
TYR A 346
ARG A 388
 None
IPW  A 601 ( 4.4A)
IPW  A 601 (-4.5A)
None
 0.73A 4r7iA-5kbrA:
21.2		 4r7iA-5kbrA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1770
VAL A1544
VAL A1570
ARG A1550
 None
 0.96A 4r7iA-5m59A:
undetectable		 4r7iA-5m59A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mt2 BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 LEU A 101
VAL A  65
TYR A 345
ARG A 108
 None
 0.92A 4r7iA-5mt2A:
undetectable		 4r7iA-5mt2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  17
VAL A  72
TYR A  94
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-4.0A)
None
None
 0.39A 4r7iA-5u94A:
24.5		 4r7iA-5u94A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x15 PUTATIVE TRANSFERASE

(Streptomyces
coelicolor) 		PF03737
(RraA-like) 		4 LEU A 184
VAL A 152
TYR A 126
ARG A 140
 None
 0.93A 4r7iA-5x15A:
undetectable		 4r7iA-5x15A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE

(Fischerella sp.
ATCC 43239) 		no annotation 4 LEU A 198
VAL A 183
VAL A 218
TYR A 129
 None
 0.94A 4r7iA-6al7A:
undetectable		 4r7iA-6al7A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 4 LEU A 112
VAL A  48
VAL A  93
ARG A  43
 None
 1.13A 4r7iA-6ap6A:
undetectable		 4r7iA-6ap6A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cay STEROL-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 962
VAL A 868
TYR A 937
ARG A 881
 None
 1.08A 4r7iA-6cayA:
undetectable		 4r7iA-6cayA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 4 LEU A 318
VAL A 340
VAL A 289
TYR A 281
 None
 1.11A 4r7iA-6f5dA:
undetectable		 4r7iA-6f5dA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 4 LEU A 378
VAL A 348
TYR A 354
ARG A 256
 None
 1.09A 4r7iA-6fv5A:
undetectable		 4r7iA-6fv5A:
12.32