SIMILAR PATTERNS OF AMINO ACIDS FOR 4R7I_A_STIA1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
LYS A  33
GLU A  51
CYH A  83
LEU A 133
 None
 0.81A 4r7iA-1h4lA:
17.5		 4r7iA-1h4lA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
LEU A 321
 None
 0.48A 4r7iA-1k9aA:
30.5		 4r7iA-1k9aA:
29.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
LEU A 389
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
 0.45A 4r7iA-1opkA:
30.3		 4r7iA-1opkA:
26.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
CYH A 807
LEU A 818
 None
 0.61A 4r7iA-1rjbA:
39.9		 4r7iA-1rjbA:
55.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 818
ASP A 829
 None
 0.59A 4r7iA-1rjbA:
39.9		 4r7iA-1rjbA:
55.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
CYH A 673
CYH A 788
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-2.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.34A 4r7iA-1t46A:
42.4		 4r7iA-1t46A:
67.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
GLU A  76
CYH A 108
LEU A 158
GLY A 168
ASP A 169
 None
 1.06A 4r7iA-1u5qA:
23.8		 4r7iA-1u5qA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
LEU A 158
GLY A 168
 None
 0.66A 4r7iA-1u5qA:
23.8		 4r7iA-1u5qA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  87
LEU A 137
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.2A)
HYM  A 400 (-4.5A)
 0.36A 4r7iA-1zltA:
14.2		 4r7iA-1zltA:
26.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
THR X  82
LEU X 137
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-4.4A)
 0.53A 4r7iA-2dq7X:
31.6		 4r7iA-2dq7X:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLU A  76
CYH A 108
LEU A 158
GLY A 168
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
None
STU  A 400 (-4.0A)
STU  A 400 ( 4.6A)
None
 0.47A 4r7iA-2gcdA:
24.6		 4r7iA-2gcdA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
LYS A 661
GLU A 678
MET A 682
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.90A 4r7iA-2henA:
31.2		 4r7iA-2henA:
29.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
LEU A 371
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.89A 4r7iA-2hk5A:
24.9		 4r7iA-2hk5A:
36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 256
ALA A 269
LYS A 271
GLU A 286
MET A 290
THR A 315
LEU A 370
ASP A 381
PHE A 382
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 0.72A 4r7iA-2hz0A:
32.0		 4r7iA-2hz0A:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		9 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
CYH A 502
LEU A 553
GLY A 563
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
None
4ST  A1687 (-4.7A)
 0.79A 4r7iA-2j0jA:
32.2		 4r7iA-2j0jA:
23.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
CYH A 502
LEU A 553
GLY A 563
ASP A 564
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
BII  A1687 (-4.1A)
BII  A1687 (-4.2A)
BII  A1687 ( 3.9A)
None
 0.88A 4r7iA-2jkmA:
31.0		 4r7iA-2jkmA:
31.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
LEU A 371
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.75A 4r7iA-2og8A:
31.3		 4r7iA-2og8A:
38.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 259
ALA A 271
LYS A 273
GLU A 288
THR A 316
LEU A 371
ASP A 382
PHE A 383
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.94A 4r7iA-2og8A:
31.3		 4r7iA-2og8A:
38.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LYS A 616
GLU A 633
MET A 637
THR A 663
CYH A 774
GLY A 795
ASP A 796
PHE A 797
 None
 0.96A 4r7iA-2ogvA:
29.1		 4r7iA-2ogvA:
95.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 596
ALA A 614
LYS A 616
GLU A 633
MET A 637
THR A 663
CYH A 666
CYH A 774
LEU A 785
GLY A 795
ASP A 796
 None
 0.66A 4r7iA-2ogvA:
29.1		 4r7iA-2ogvA:
95.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A  21
ALA A  34
LYS A  36
GLU A  53
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
AGS  A3001 (-2.8A)
 1.07A 4r7iA-2pmiA:
20.1		 4r7iA-2pmiA:
27.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
GLU A 534
MET A 538
CYH A 622
LEU A 633
 None
 0.49A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
CYH A 622
 None
 0.66A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
LYS A 217
GLU A 230
THR A 265
LEU A 328
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
 0.67A 4r7iA-2qluA:
24.6		 4r7iA-2qluA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
LYS A 653
GLU A 670
MET A 674
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.02A 4r7iA-2qobA:
31.7		 4r7iA-2qobA:
29.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
LYS A 707
GLU A 724
MET A 728
THR A 753
ASP A 818
 None
 0.93A 4r7iA-2r2pA:
32.0		 4r7iA-2r2pA:
31.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
LYS A 707
GLU A 724
THR A 753
LEU A 807
ASP A 818
 None
 1.07A 4r7iA-2r2pA:
32.0		 4r7iA-2r2pA:
31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
LYS A 653
MET A 674
THR A 699
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.3A)
None
 0.91A 4r7iA-2xyuA:
27.2		 4r7iA-2xyuA:
30.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1010
ALA A1028
LYS A1030
GLU A1047
MET A1051
GLY A1149
 S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
None
 0.63A 4r7iA-2z8cA:
30.9		 4r7iA-2z8cA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
LYS A 275
GLU A 290
MET A 294
THR A 319
ASP A 385
 None
 0.85A 4r7iA-2zv7A:
31.2		 4r7iA-2zv7A:
35.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 261
ALA A 273
LYS A 275
THR A 319
LEU A 374
ASP A 385
 None
 0.68A 4r7iA-2zv7A:
31.2		 4r7iA-2zv7A:
35.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
ALA A 512
GLU A 531
MET A 535
CYH A 619
LEU A 630
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
 0.51A 4r7iA-3c4fA:
27.6		 4r7iA-3c4fA:
48.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
ALA A 512
GLU A 531
MET A 535
LEU A 630
PHE A 489
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 (-4.6A)
C4F  A   1 (-3.7A)
 0.81A 4r7iA-3c4fA:
27.6		 4r7iA-3c4fA:
48.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
LEU A 321
 None
 0.48A 4r7iA-3d7uA:
24.7		 4r7iA-3d7uA:
35.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
MET A  77
CYH A 105
LEU A 155
ASP A 169
 DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
None
DRK  A   1 (-4.1A)
DRK  A   1 (-4.6A)
None
 0.77A 4r7iA-3f3zA:
21.7		 4r7iA-3f3zA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
GLU A  71
THR A 106
ASP A 168
PHE A 169
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
 0.71A 4r7iA-3gp0A:
22.2		 4r7iA-3gp0A:
26.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
CYH A1018
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
8ST  A2001 ( 4.7A)
None
None
8ST  A2001 ( 3.7A)
 0.55A 4r7iA-3hngA:
42.0		 4r7iA-3hngA:
44.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
LEU A 767
 None
 0.74A 4r7iA-3kulA:
32.3		 4r7iA-3kulA:
31.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 VAL A 689
ALA A 700
LYS A 702
GLU A 715
CYH A 748
LEU A 804
ASP A 828
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
ADP  A2101 (-4.2A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.91A 4r7iA-3lj0A:
21.7		 4r7iA-3lj0A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A 566
ALA A 579
LYS A 581
GLU A 596
LEU A 684
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
ANP  A 877 (-2.9A)
 0.75A 4r7iA-3lltA:
20.9		 4r7iA-3lltA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
 0.65A 4r7iA-3mdyA:
24.7		 4r7iA-3mdyA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  33
ALA A  46
LYS A  48
GLU A  66
CYH A 106
LEU A 156
 None
 0.77A 4r7iA-3mi9A:
21.6		 4r7iA-3mi9A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
LEU A 337
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
None
 1.11A 4r7iA-3my0A:
24.9		 4r7iA-3my0A:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  44
ALA A  57
LYS A  59
GLU A  77
LEU A 163
ASP A 174
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 ( 4.4A)
ANP  A 430 (-4.4A)
ANP  A 430 (-2.8A)
 0.79A 4r7iA-3nieA:
19.9		 4r7iA-3nieA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  96
ALA A 109
LYS A 111
GLU A 130
MET A 134
LEU A 212
ASP A 223
 JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
SO4  A   5 ( 4.5A)
 0.63A 4r7iA-3nuuA:
22.9		 4r7iA-3nuuA:
24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
LYS A 578
GLU A 596
MET A 600
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.60A 4r7iA-3ppzA:
27.9		 4r7iA-3ppzA:
33.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 206
ALA A 217
LYS A 219
GLU A 232
THR A 267
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.6A)
 0.67A 4r7iA-3q4tA:
23.9		 4r7iA-3q4tA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  71
ALA A  84
LYS A  86
GLU A 115
THR A 144
LEU A 197
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
ANP  A1634 (-4.4A)
 0.63A 4r7iA-3q5iA:
19.6		 4r7iA-3q5iA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B 603
ALA B 616
LYS B 618
GLU B 635
CYH B 889
GLY B 952
 None
 0.78A 4r7iA-3qd2B:
20.5		 4r7iA-3qd2B:
25.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
CYH A 619
LEU A 630
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 ( 4.4A)
 0.60A 4r7iA-3tt0A:
34.4		 4r7iA-3tt0A:
44.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
CYH A 919
CYH A1024
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
None
4TT  A2001 (-4.8A)
None
 0.71A 4r7iA-3vidA:
35.9		 4r7iA-3vidA:
44.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
CYH A 919
CYH A1024
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
DTT  A1202 (-2.0A)
LEV  A1201 (-4.8A)
 0.59A 4r7iA-3wzdA:
34.8		 4r7iA-3wzdA:
48.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
THR A 697
 None
 0.73A 4r7iA-3zfxA:
31.5		 4r7iA-3zfxA:
31.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
CYH A1024
LEU A1035
ASP A1046
PHE A1047
 None
B49  A2000 (-3.5A)
B49  A2000 (-3.0A)
None
B49  A2000 (-4.2A)
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.63A 4r7iA-4agdA:
40.8		 4r7iA-4agdA:
50.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  18
ALA A  31
LYS A  33
GLU A  51
CYH A  83
CYH A 122
LEU A 133
ASP A 144
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.3A)
None
D15  A 500 (-4.5A)
D15  A 500 (-3.7A)
 0.73A 4r7iA-4aguA:
22.7		 4r7iA-4aguA:
25.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
THR A 169
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
 0.82A 4r7iA-4aw5A:
26.7		 4r7iA-4aw5A:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  69
ALA A  82
LYS A  84
LEU A 189
GLY A 199
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.5A)
R4L  A1394 ( 4.1A)
None
 0.70A 4r7iA-4b99A:
20.9		 4r7iA-4b99A:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
LYS A 655
GLU A 672
THR A 701
LEU A 773
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.91A 4r7iA-4ckrA:
33.2		 4r7iA-4ckrA:
35.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
LEU A 773
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.1A)
 0.88A 4r7iA-4ckrA:
33.2		 4r7iA-4ckrA:
35.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
LEU A 501
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-4.4A)
 0.73A 4r7iA-4f4pA:
29.4		 4r7iA-4f4pA:
31.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 863
ALA A 880
LYS A 882
GLU A 898
LEU A 983
GLY A 993
 None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.7A)
None
 0.78A 4r7iA-4gl9A:
28.2		 4r7iA-4gl9A:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 836
ALA A 853
LYS A 855
GLU A 871
CYH A 945
LEU A 956
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 (-4.5A)
 0.55A 4r7iA-4hviA:
29.8		 4r7iA-4hviA:
28.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		6 VAL A 140
ALA A 156
LYS A 158
THR A 205
LEU A 259
GLY A 269
 None
 0.63A 4r7iA-4hzsA:
27.0		 4r7iA-4hzsA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 140
ALA A 156
LYS A 158
THR A 205
LEU A 259
GLY A 269
ASP A 270
 1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 (-4.6A)
None
None
 0.69A 4r7iA-4id7A:
29.7		 4r7iA-4id7A:
32.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ALA A 506
GLU A 525
MET A 529
LEU A 624
ASP A 635
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.4A)
MG  A 802 ( 3.0A)
 0.75A 4r7iA-4k33A:
28.6		 4r7iA-4k33A:
48.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
LEU A 624
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.4A)
 0.52A 4r7iA-4k33A:
28.6		 4r7iA-4k33A:
48.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  86
ALA A  99
LYS A 101
GLU A 117
MET A 121
CYH A 149
 STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-4.2A)
 0.76A 4r7iA-4mvfA:
18.5		 4r7iA-4mvfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
LYS B  53
GLU B  70
LEU B 151
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
 0.57A 4r7iA-4o27B:
19.1		 4r7iA-4o27B:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
None
 0.84A 4r7iA-4o38A:
19.7		 4r7iA-4o38A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  67
LYS A  69
GLU A  85
THR A 123
CYH A 126
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
None
 0.66A 4r7iA-4o38A:
19.7		 4r7iA-4o38A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.67A 4r7iA-4o38A:
19.7		 4r7iA-4o38A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
LYS A  69
GLU A  85
THR A 123
CYH A 126
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-4.3A)
SIN  A 401 ( 4.5A)
 0.39A 4r7iA-4o38A:
19.7		 4r7iA-4o38A:
25.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 644
GLU A 661
MET A 665
CYH A 694
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 3.7A)
None
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.85A 4r7iA-4rt7A:
34.0		 4r7iA-4rt7A:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
CYH A 807
LEU A 818
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
None
P30  A1001 (-4.6A)
P30  A1001 (-3.9A)
 0.51A 4r7iA-4rt7A:
34.0		 4r7iA-4rt7A:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 818
ASP A 829
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.39A 4r7iA-4rt7A:
34.0		 4r7iA-4rt7A:
51.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
LEU A 136
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
 0.89A 4r7iA-4ueuA:
31.4		 4r7iA-4ueuA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
CYH A 608
LEU A 619
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
 0.64A 4r7iA-4xcuA:
27.2		 4r7iA-4xcuA:
43.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 VAL B 275
ALA B 288
LYS B 290
MET B 309
THR B 334
LEU B 389
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 (-3.3A)
1N1  B 601 (-4.3A)
 0.55A 4r7iA-4xeyB:
31.4		 4r7iA-4xeyB:
31.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.54A 4r7iA-4xufA:
30.4		 4r7iA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
MET A 665
CYH A 694
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.72A 4r7iA-4xufA:
30.4		 4r7iA-4xufA:
60.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
LYS A 490
GLU A 509
THR A 539
LEU A 595
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-4.4A)
 0.64A 4r7iA-4yffA:
25.0		 4r7iA-4yffA:
27.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 VAL A 201
ALA A 214
LYS A 216
GLU A 235
LEU A 319
ASP A 330
 AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
AN2  A 601 (-3.0A)
 0.80A 4r7iA-4yhjA:
20.1		 4r7iA-4yhjA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 VAL A  42
ALA A  55
LYS A  57
GLU A  76
THR A 105
LEU A 158
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
ADP  A 506 (-4.7A)
 0.51A 4r7iA-4ysjA:
22.4		 4r7iA-4ysjA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
CYH A 619
LEU A 630
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
 0.44A 4r7iA-5a46A:
34.7		 4r7iA-5a46A:
40.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 258
ALA A 275
LYS A 277
GLU A 290
THR A 325
LEU A 386
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.9A)
 0.50A 4r7iA-5e8yA:
24.6		 4r7iA-5e8yA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		6 VAL A 548
ALA A 561
LYS A 563
THR A 611
LEU A 664
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-3.6A)
None
 0.78A 4r7iA-5ezrA:
18.3		 4r7iA-5ezrA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
LYS A 930
GLU A 947
LEU A1030
GLY A1040
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.71A 4r7iA-5f1zA:
27.6		 4r7iA-5f1zA:
30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 471
ALA A 481
LYS A 483
THR A 529
CYH A 532
GLY A 593
 5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.6A)
5XJ  A 801 ( 3.7A)
 0.59A 4r7iA-5fd2A:
14.2		 4r7iA-5fd2A:
28.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
CYH A 677
CYH A 814
LEU A 825
ASP A 836
PHE A 837
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 (-3.4A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.44A 4r7iA-5grnA:
42.3		 4r7iA-5grnA:
56.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL

(Homo sapiens) 		PF03109
(ABC1) 		6 VAL A 344
ALA A 356
LYS A 358
GLU A 411
THR A 445
ASP A 507
 ANP  A 700 (-4.7A)
ANP  A 700 ( 3.7A)
ANP  A 700 (-3.0A)
None
ANP  A 700 (-4.1A)
ANP  A 700 (-2.8A)
 0.72A 4r7iA-5i35A:
7.4		 4r7iA-5i35A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  65
ALA A  77
GLU A  95
MET A  99
CYH A 133
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-4.6A)
IDV  A 401 (-4.4A)
 0.73A 4r7iA-5i3oA:
22.1		 4r7iA-5i3oA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
CYH A  93
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
TPO  A 145 (-4.1A)
6G2  A 901 (-4.7A)
 0.66A 4r7iA-5j5tA:
20.8		 4r7iA-5j5tA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 VAL A  25
ALA A  38
LYS A  40
GLU A  57
CYH A  89
LEU A 139
ASP A 150
 7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.3A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 0.92A 4r7iA-5tvtA:
21.9		 4r7iA-5tvtA:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 124
ALA A 137
GLU A 157
THR A 187
CYH A 190
GLY A 250
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
 0.60A 4r7iA-5vcxA:
22.7		 4r7iA-5vcxA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 VAL A 374
ALA A 388
LYS A 390
GLU A 409
MET A 413
CYH A 441
 EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
None
EE4  A 701 (-4.6A)
 0.82A 4r7iA-6c0tA:
15.7		 4r7iA-6c0tA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 VAL A 889
ALA A 906
LYS A 908
GLU A 925
LEU A1010
GLY A1020
 ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.5A)
None
 0.55A 4r7iA-6c7yA:
28.0		 4r7iA-6c7yA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
LEU A 189
 None
 0.65A 4r7iA-6c9dA:
21.2		 4r7iA-6c9dA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 ALA A 217
THR A 264
LEU A 319
GLY A 329
ASP A 330
PHE A 331
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
 0.60A 4r7iA-6cz4A:
29.3		 4r7iA-6cz4A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 VAL A 205
ALA A 217
THR A 264
LEU A 319
GLY A 329
PHE A 331
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
FKY  A9001 (-3.9A)
 0.76A 4r7iA-6cz4A:
29.3		 4r7iA-6cz4A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 VAL A 177
ALA A 191
LYS A 193
GLU A 208
LEU A 297
ASP A 327
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
3NG  A 501 (-4.5A)
 0.74A 4r7iA-6fylA:
22.0		 4r7iA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR

(Homo sapiens) 		PF01858
(RB_A) 		4 LEU A 487
VAL A 494
TYR A 446
ARG A 544
 None
 1.12A 4r7iA-1ad6A:
undetectable		 4r7iA-1ad6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fjj HYPOTHETICAL 17.1
KDA PROTEIN IN
MODC-BIOA INTERGENIC
REGION

(Escherichia
coli) 		PF01161
(PBP) 		4 VAL A  65
VAL A 120
TYR A  51
ARG A 127
 None
 1.11A 4r7iA-1fjjA:
undetectable		 4r7iA-1fjjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU B 335
VAL B 162
TYR B 171
ARG B 350
 None
 1.07A 4r7iA-1hr7B:
undetectable		 4r7iA-1hr7B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		4 VAL S 122
VAL S  86
TYR S 108
ARG S 715
 None
 1.08A 4r7iA-1i84S:
undetectable		 4r7iA-1i84S:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luz PROTEIN K3

(Vaccinia virus) 		PF00575
(S1) 		4 LEU A  58
VAL A  79
VAL A  44
TYR A  81
 None
 0.91A 4r7iA-1luzA:
undetectable		 4r7iA-1luzA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		4 LEU A 253
VAL A 420
TYR A 427
ARG A 374
 None
 0.79A 4r7iA-1q15A:
undetectable		 4r7iA-1q15A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7j PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF FAMILY

(Enterococcus
faecalis) 		PF02567
(PhzC-PhzF) 		4 LEU A 169
VAL A 177
TYR A 129
ARG A 231
 None
 1.13A 4r7iA-1s7jA:
undetectable		 4r7iA-1s7jA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 LEU A 317
VAL A 265
TYR A 261
ARG A 199
 None
 1.10A 4r7iA-1sb8A:
undetectable		 4r7iA-1sb8A:
26.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 595
VAL A 654
VAL A 668
TYR A 672
ARG A 791
 STI  A   3 ( 3.8A)
STI  A   3 (-4.3A)
STI  A   3 (-4.6A)
STI  A   3 ( 4.0A)
None
 0.61A 4r7iA-1t46A:
42.4		 4r7iA-1t46A:
67.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 676
VAL A 586
VAL A 610
TYR A 626
 None
 1.13A 4r7iA-1tkcA:
undetectable		 4r7iA-1tkcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 244
VAL A 399
VAL A 238
TYR A 332
 None
 1.09A 4r7iA-1ulzA:
undetectable		 4r7iA-1ulzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxu PEROXISOMAL
BIOGENESIS FACTOR 13

(Mus musculus) 		PF14604
(SH3_9) 		4 LEU A  61
VAL A  74
VAL A  18
ARG A  54
 None
 1.13A 4r7iA-1wxuA:
undetectable		 4r7iA-1wxuA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		4 LEU A  14
VAL A  51
TYR A  44
ARG A 221
 None
None
MET  A 301 (-3.7A)
None
 1.00A 4r7iA-1xs5A:
undetectable		 4r7iA-1xs5A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  68
TYR A  86
ARG A 129
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
 0.64A 4r7iA-1zltA:
14.2		 4r7iA-1zltA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Saccharomyces
cerevisiae) 		PF00977
(His_biosynth) 		4 LEU A 116
VAL A 133
TYR A 171
ARG A 138
 None
 1.13A 4r7iA-2agkA:
undetectable		 4r7iA-2agkA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A 256
VAL A 264
VAL A 244
TYR A 293
 None
 1.03A 4r7iA-2avfA:
undetectable		 4r7iA-2avfA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
VAL X  67
TYR X  84
ARG X 129
 STU  X 902 (-3.8A)
None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
 0.69A 4r7iA-2dq7X:
31.6		 4r7iA-2dq7X:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dws COPPER-CONTAINING
NITRITE REDUCTASE

(Rhodobacter
sphaeroides) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A 288
VAL A 296
VAL A 276
TYR A 325
 None
 1.07A 4r7iA-2dwsA:
undetectable		 4r7iA-2dwsA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 233
VAL A 275
VAL A 270
ARG A 453
 None
 0.98A 4r7iA-2fqdA:
undetectable		 4r7iA-2fqdA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE

(Mus musculus) 		PF02485
(Branch) 		4 LEU A 139
VAL A 176
VAL A 154
ARG A  98
 None
 0.84A 4r7iA-2gamA:
undetectable		 4r7iA-2gamA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gam BETA-1,6-N-ACETYLGLU
COSAMINYLTRANSFERASE

(Mus musculus) 		PF02485
(Branch) 		4 VAL A 176
VAL A 154
TYR A 125
ARG A  98
 None
 1.05A 4r7iA-2gamA:
undetectable		 4r7iA-2gamA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0b NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		4 LEU A 457
VAL A 423
VAL A 331
TYR A 294
 None
 1.11A 4r7iA-2h0bA:
undetectable		 4r7iA-2h0bA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 323
TYR A 340
ARG A 385
 H8H  A 534 (-3.8A)
None
H8H  A 534 (-4.3A)
None
 0.85A 4r7iA-2h8hA:
29.7		 4r7iA-2h8hA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icu HYPOTHETICAL PROTEIN
YEDK

(Escherichia
coli) 		PF02586
(SRAP) 		4 LEU A  97
VAL A  66
TYR A  70
ARG A  31
 None
 1.04A 4r7iA-2icuA:
undetectable		 4r7iA-2icuA:
20.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
VAL A 301
TYR A 318
ARG A 363
 None
None
1N8  A 501 ( 3.7A)
None
 0.95A 4r7iA-2og8A:
31.3		 4r7iA-2og8A:
38.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 588
VAL A 647
VAL A 661
TYR A 665
ARG A 777
 None
 0.50A 4r7iA-2ogvA:
29.1		 4r7iA-2ogvA:
95.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		4 LEU A  36
VAL A  90
VAL A  67
ARG A 246
 None
 1.09A 4r7iA-2olaA:
undetectable		 4r7iA-2olaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 364
VAL A 242
TYR A 255
ARG A 174
 None
 1.11A 4r7iA-2p0uA:
undetectable		 4r7iA-2p0uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbk KSHV PROTEASE

(Human
gammaherpesvirus
8) 		PF00716
(Peptidase_S21) 		4 LEU A  56
VAL A  52
TYR A   6
ARG A 142
 None
 1.09A 4r7iA-2pbkA:
undetectable		 4r7iA-2pbkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pet LUTHERAN BLOOD GROUP
GLYCOPROTEIN

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 LEU A  79
VAL A   6
VAL A  96
TYR A  92
 None
 0.94A 4r7iA-2petA:
undetectable		 4r7iA-2petA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 487
VAL A 562
TYR A 566
ARG A 625
 None
None
None
SO4  A 303 ( 2.9A)
 0.55A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 487
VAL A 562
TYR A 566
ARG A 664
 None
 0.97A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		4 VAL A 644
VAL A 720
TYR A 684
ARG A 660
 None
 0.96A 4r7iA-2r8qA:
undetectable		 4r7iA-2r8qA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 456
VAL A 112
TYR A 429
ARG A 217
 PG4  A1596 (-4.3A)
None
PG4  A1596 (-4.8A)
None
 0.99A 4r7iA-2v6oA:
undetectable		 4r7iA-2v6oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 LEU A   9
VAL A 234
VAL A  39
TYR A 244
 None
 1.03A 4r7iA-2yvtA:
undetectable		 4r7iA-2yvtA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1002
VAL A1060
VAL A1074
ARG A1131
 S91  A   1 ( 4.1A)
None
None
PTR  A1163 ( 3.6A)
 0.96A 4r7iA-2z8cA:
30.9		 4r7iA-2z8cA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 487
VAL A 562
TYR A 566
ARG A 625
 M33  A1996 (-4.0A)
None
M33  A1996 ( 4.7A)
None
 0.59A 4r7iA-3b2tA:
33.4		 4r7iA-3b2tA:
45.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cu2 RIBULOSE-5-PHOSPHATE
3-EPIMERASE

(Histophilus
somni) 		PF00834
(Ribul_P_3_epim) 		4 LEU A  42
VAL A  57
VAL A  87
ARG A 159
 None
 1.06A 4r7iA-3cu2A:
undetectable		 4r7iA-3cu2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00005
(ABC_tran)
PF03459
(TOBE) 		4 LEU A 151
VAL A  23
TYR A  28
ARG A  56
 None
 1.05A 4r7iA-3d31A:
undetectable		 4r7iA-3d31A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		4 LEU A 292
VAL A 360
TYR A 417
ARG A 491
 None
 1.13A 4r7iA-3dwcA:
undetectable		 4r7iA-3dwcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e82 PUTATIVE
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 VAL A 147
VAL A 156
TYR A 291
ARG A 136
 None
 1.12A 4r7iA-3e82A:
undetectable		 4r7iA-3e82A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3faw RETICULOCYTE BINDING
PROTEIN

(Streptococcus
agalactiae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 LEU A1045
VAL A1098
TYR A1094
ARG A 866
 None
None
None
CL  A1226 (-4.0A)
 1.11A 4r7iA-3fawA:
undetectable		 4r7iA-3fawA:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 833
VAL A 892
VAL A 907
TYR A 911
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.5A)
8ST  A2001 (-4.9A)
 0.33A 4r7iA-3hngA:
42.0		 4r7iA-3hngA:
44.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		4 LEU A 471
VAL A 169
VAL A 484
ARG A 363
 None
 1.11A 4r7iA-3hq2A:
undetectable		 4r7iA-3hq2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A  92
VAL A 177
VAL A 139
TYR A 166
 None
 1.09A 4r7iA-3ifrA:
undetectable		 4r7iA-3ifrA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		4 LEU A 582
VAL A 545
VAL A 551
TYR A 578
 None
 1.11A 4r7iA-3jbyA:
undetectable		 4r7iA-3jbyA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S17,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S25,
MITOCHONDRIAL

(Bos taurus) 		PF00366
(Ribosomal_S17)
PF14955
(MRP-S24) 		4 LEU Q  40
VAL c  48
TYR c  57
ARG Q  29
 None
 1.11A 4r7iA-3jd5Q:
undetectable		 4r7iA-3jd5Q:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN

(Suregada
multiflora) 		PF00161
(RIP) 		4 LEU A 157
VAL A  54
VAL A  73
TYR A  78
 None
 1.01A 4r7iA-3ku0A:
undetectable		 4r7iA-3ku0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		4 LEU A 104
VAL A  15
VAL A  43
TYR A 102
 None
 1.06A 4r7iA-3kzaA:
undetectable		 4r7iA-3kzaA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  49
VAL A 104
TYR A 122
ARG A 165
 XFE  A 351 (-4.2A)
None
None
TPO  A 197 ( 3.1A)
 0.75A 4r7iA-3mvjA:
15.1		 4r7iA-3mvjA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		4 LEU A 318
VAL A 363
VAL A 379
ARG A  32
 None
 0.95A 4r7iA-3nraA:
undetectable		 4r7iA-3nraA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		4 LEU A 139
VAL A  93
VAL A 109
TYR A 220
 None
 0.93A 4r7iA-3o8jA:
undetectable		 4r7iA-3o8jA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		4 LEU A 120
VAL A  31
VAL A  59
TYR A 118
 None
 1.00A 4r7iA-3ph5A:
undetectable		 4r7iA-3ph5A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qzb PUTATIVE SUPEROXIDE
REDUCTASE

(Thermotoga
maritima) 		PF01880
(Desulfoferrodox) 		4 LEU A 120
VAL A  39
VAL A  58
TYR A 114
 None
 1.03A 4r7iA-3qzbA:
undetectable		 4r7iA-3qzbA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 899
VAL A 914
ARG A1027
 LEV  A1201 ( 3.8A)
None
None
None
 0.51A 4r7iA-3wzdA:
34.8		 4r7iA-3wzdA:
48.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		4 LEU A 171
VAL A 206
VAL A 231
TYR A 227
 None
 0.97A 4r7iA-3zxlA:
undetectable		 4r7iA-3zxlA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
VAL A 114
VAL A 128
ARG A 175
 939  A1331 (-3.7A)
None
None
None
 0.59A 4r7iA-4a4lA:
22.5		 4r7iA-4a4lA:
26.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aoa BETA-PHENYLALANINE
AMINOTRANSFERASE

(Variovorax
paradoxus) 		PF00202
(Aminotran_3) 		4 LEU A 164
VAL A 181
VAL A 204
ARG A 368
 None
 0.96A 4r7iA-4aoaA:
undetectable		 4r7iA-4aoaA:
23.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 560
VAL A 617
TYR A 635
ARG A 691
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-4.7A)
None
 1.08A 4r7iA-4at3A:
33.0		 4r7iA-4at3A:
37.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 663
VAL A 721
TYR A 739
ARG A 781
 AGS  A1985 (-4.2A)
None
None
TPO  A 816 ( 3.0A)
 0.72A 4r7iA-4crsA:
20.5		 4r7iA-4crsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		4 LEU A 229
VAL A 268
VAL A 259
TYR A 191
 None
 0.97A 4r7iA-4dimA:
undetectable		 4r7iA-4dimA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 LEU A  16
VAL A  71
TYR A  89
ARG A 132
 ANP  A 300 (-4.7A)
None
ANP  A 300 (-4.3A)
None
 1.07A 4r7iA-4eqmA:
21.4		 4r7iA-4eqmA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk5 DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF16727
(REV1_C) 		4 LEU E1203
VAL E1236
VAL E1250
TYR E1244
 None
 1.01A 4r7iA-4gk5E:
undetectable		 4r7iA-4gk5E:
17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 855
VAL A 911
TYR A 931
ARG A 975
 IZA  A2001 (-3.7A)
None
None
None
 0.94A 4r7iA-4gl9A:
28.2		 4r7iA-4gl9A:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 LEU C 787
VAL C 819
TYR C 773
ARG C 807
 None
 1.08A 4r7iA-4hb4C:
undetectable		 4r7iA-4hb4C:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB

(Pseudomonas
aeruginosa) 		PF13360
(PQQ_2) 		4 LEU A  32
VAL A 326
VAL A 344
TYR A 332
 None
 1.12A 4r7iA-4hdjA:
undetectable		 4r7iA-4hdjA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		4 LEU B 201
VAL B  30
VAL B  87
TYR B  35
 None
 1.12A 4r7iA-4hzuB:
undetectable		 4r7iA-4hzuB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00069
(Pkinase) 		4 LEU A  45
VAL A 100
VAL A 114
ARG A 161
 None
 0.80A 4r7iA-4j7bA:
22.3		 4r7iA-4j7bA:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 478
VAL A 553
TYR A 557
ARG A 616
 ACP  A 801 (-3.8A)
None
None
None
 0.66A 4r7iA-4k33A:
28.6		 4r7iA-4k33A:
48.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5n URACIL-DNA
GLYCOSYLASE

(Human
alphaherpesvirus
1) 		PF03167
(UDG) 		4 LEU A  99
VAL A  83
TYR A  74
ARG A 167
 None
 1.08A 4r7iA-4l5nA:
undetectable		 4r7iA-4l5nA:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 323
TYR A 340
ARG A 385
 VGG  A 601 (-3.2A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
None
 0.75A 4r7iA-4lggA:
28.5		 4r7iA-4lggA:
33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 LEU A 104
VAL A 118
VAL A 135
TYR A 128
 None
 1.02A 4r7iA-4my5A:
undetectable		 4r7iA-4my5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 627
VAL A 685
TYR A 703
ARG A 745
 None
None
None
TPO  A 780 ( 2.8A)
 0.83A 4r7iA-4otdA:
21.6		 4r7iA-4otdA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0w DNA REPAIR PROTEIN
RAD2

(Saccharomyces
cerevisiae) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 VAL A 816
VAL A  75
TYR A 825
ARG A 940
 None
 1.10A 4r7iA-4q0wA:
undetectable		 4r7iA-4q0wA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q14 5-HYDROXYISOURATE
HYDROLASE

(Brucella
abortus) 		PF00576
(Transthyretin) 		4 LEU A  52
VAL A 103
VAL A  22
TYR A  62
 None
 1.08A 4r7iA-4q14A:
undetectable		 4r7iA-4q14A:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
VAL A  65
TYR A  83
ARG A 128
 ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.5A)
None
 1.02A 4r7iA-4ueuA:
31.4		 4r7iA-4ueuA:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 LEU A  66
VAL A  58
VAL A   4
TYR A 108
 None
None
None
UCA  A 301 (-3.6A)
 1.12A 4r7iA-4w97A:
undetectable		 4r7iA-4w97A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		4 LEU A 104
VAL A 159
TYR A 177
ARG A 220
 ATP  A 501 ( 4.3A)
None
None
TPO  A 252 ( 2.9A)
 0.76A 4r7iA-4wb7A:
15.3		 4r7iA-4wb7A:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
VAL A 675
TYR A 693
ARG A 810
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.4A)
None
 0.81A 4r7iA-4xufA:
30.4		 4r7iA-4xufA:
60.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1y GALECTIN-1

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 LEU A   4
VAL A  87
VAL A  23
ARG A  73
 None
CSO  A  88 ( 3.1A)
None
6S2  A 202 (-3.8A)
 1.10A 4r7iA-4y1yA:
undetectable		 4r7iA-4y1yA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8j VWA2

(Sulfolobus
acidocaldarius) 		PF00092
(VWA) 		4 LEU A   8
VAL A 293
VAL A 242
ARG A 286
 None
None
None
CIT  A1373 (-3.9A)
 1.06A 4r7iA-5a8jA:
undetectable		 4r7iA-5a8jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA

(Paraburkholderia
xenovorans) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 LEU A  60
VAL A  95
VAL A  67
ARG A 109
 None
 1.09A 4r7iA-5aewA:
undetectable		 4r7iA-5aewA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5akr COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 LEU A 256
VAL A 264
VAL A 244
TYR A 293
 None
 1.05A 4r7iA-5akrA:
undetectable		 4r7iA-5akrA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1y 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Aeropyrum
pernix) 		PF13561
(adh_short_C2) 		4 LEU A 125
VAL A 180
VAL A  85
TYR A 176
 None
 1.12A 4r7iA-5b1yA:
undetectable		 4r7iA-5b1yA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 LEU A 408
VAL A 206
VAL A 221
TYR A 419
 None
 1.03A 4r7iA-5bn4A:
undetectable		 4r7iA-5bn4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 LEU A 427
VAL A 477
TYR A 242
ARG A 459
 None
None
None
SO4  A 601 (-3.6A)
 1.04A 4r7iA-5cwaA:
undetectable		 4r7iA-5cwaA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 599
VAL A 658
TYR A 676
ARG A 817
 748  A1001 (-3.8A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
None
 0.69A 4r7iA-5grnA:
42.3		 4r7iA-5grnA:
56.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 4 LEU A 489
VAL A 521
VAL A 473
TYR A 469
 None
 1.08A 4r7iA-5h4eA:
undetectable		 4r7iA-5h4eA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr6 RLMN METHYLASE

(Escherichia
coli) 		PF04055
(Radical_SAM) 		4 LEU A 230
VAL A 188
VAL A 173
ARG A  25
 None
 1.11A 4r7iA-5hr6A:
undetectable		 4r7iA-5hr6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 VAL A 117
VAL A  74
TYR A  81
ARG A 150
 None
 1.10A 4r7iA-5hxaA:
undetectable		 4r7iA-5hxaA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 328
VAL A 342
TYR A 346
ARG A 388
 None
IPW  A 601 ( 4.4A)
IPW  A 601 (-4.5A)
None
 0.73A 4r7iA-5kbrA:
21.2		 4r7iA-5kbrA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 LEU A1770
VAL A1544
VAL A1570
ARG A1550
 None
 0.96A 4r7iA-5m59A:
undetectable		 4r7iA-5m59A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mt2 BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 LEU A 101
VAL A  65
TYR A 345
ARG A 108
 None
 0.92A 4r7iA-5mt2A:
undetectable		 4r7iA-5mt2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  17
VAL A  72
TYR A  94
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-4.0A)
None
None
 0.39A 4r7iA-5u94A:
24.5		 4r7iA-5u94A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x15 PUTATIVE TRANSFERASE

(Streptomyces
coelicolor) 		PF03737
(RraA-like) 		4 LEU A 184
VAL A 152
TYR A 126
ARG A 140
 None
 0.93A 4r7iA-5x15A:
undetectable		 4r7iA-5x15A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6al7 12-EPI-HAPALINDOLE
C/U SYNTHASE

(Fischerella sp.
ATCC 43239) 		no annotation 4 LEU A 198
VAL A 183
VAL A 218
TYR A 129
 None
 0.94A 4r7iA-6al7A:
undetectable		 4r7iA-6al7A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 4 LEU A 112
VAL A  48
VAL A  93
ARG A  43
 None
 1.13A 4r7iA-6ap6A:
undetectable		 4r7iA-6ap6A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cay STEROL-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 962
VAL A 868
TYR A 937
ARG A 881
 None
 1.08A 4r7iA-6cayA:
undetectable		 4r7iA-6cayA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 4 LEU A 318
VAL A 340
VAL A 289
TYR A 281
 None
 1.11A 4r7iA-6f5dA:
undetectable		 4r7iA-6f5dA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 4 LEU A 378
VAL A 348
TYR A 354
ARG A 256
 None
 1.09A 4r7iA-6fv5A:
undetectable		 4r7iA-6fv5A:
12.32