SIMILAR PATTERNS OF AMINO ACIDS FOR 4R3A_B_RBFB402

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1jnu	PHY3 PROTEIN (Adiantum capillus-veneris)	PF13426 (PAS_9)	5	ASN A 965 LEU A 969 GLN A 970 VAL A 979 PHE A1025	FMN  A1033 (-3.2A) FMN  A1033 (-4.1A) FMN  A1033 (-3.1A) FMN  A1033 ( 4.9A) FMN  A1033 ( 4.6A)	0.76A	4r3aB-1jnuA: 15.7	4r3aB-1jnuA: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1k1x	4-ALPHA-GLUCANOTRANS FERASE (Thermococcus litoralis)	PF03065 (Glyco_hydro_57) PF09094 (DUF1925) PF09095 (DUF1926)	5	ILE A  10 LEU A  66 LEU A  72 MET A  35 PHE A  34	None	1.36A	4r3aB-1k1xA: undetectable	4r3aB-1k1xA: 20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1n9l	PUTATIVE BLUE LIGHT RECEPTOR (Chlamydomonas reinhardtii)	PF13426 (PAS_9)	5	ASN A  56 LEU A  60 GLN A  61 VAL A  70 PHE A 116	FMN  A 500 (-2.9A) FMN  A 500 (-4.3A) FMN  A 500 (-3.3A) FMN  A 500 (-4.3A) FMN  A 500 (-4.8A)	0.62A	4r3aB-1n9lA: 15.6	4r3aB-1n9lA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1olt	OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE (Escherichia coli)	PF04055 (Radical_SAM) PF06969 (HemN_C)	5	THR A 206 ILE A 201 GLU A 200 ASN A 196 LEU A 232	None	1.47A	4r3aB-1oltA: undetectable	4r3aB-1oltA: 23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vdk	FUMARATE HYDRATASE CLASS II (Thermus thermophilus)	PF00206 (Lyase_1) PF10415 (FumaraseC_C)	5	ASN A 359 VAL A 275 LEU A 274 MET A 148 PHE A 144	None	1.48A	4r3aB-1vdkA: undetectable	4r3aB-1vdkA: 24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2dt9	ASPARTOKINASE (Thermus thermophilus)	PF01842 (ACT) PF13840 (ACT_7)	5	ILE A 129 LEU A  12 VAL A 101 MET A 115 PHE A 116	None	1.26A	4r3aB-2dt9A: 2.5	4r3aB-2dt9A: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ehh	DIHYDRODIPICOLINATE SYNTHASE (Aquifex aeolicus)	PF00701 (DHDPS)	5	ILE A 173 LEU A 222 VAL A 202 LEU A 184 PHE A 181	None	1.39A	4r3aB-2ehhA: undetectable	4r3aB-2ehhA: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2f4z	TGTWINSCAN_2721 - E2 DOMAIN (Toxoplasma gondii)	PF00179 (UQ_con)	5	LEU A 155 GLN A 152 VAL A  65 LEU A 148 MET A 111	None	1.37A	4r3aB-2f4zA: undetectable	4r3aB-2f4zA: 18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2gf9	RAS-RELATED PROTEIN RAB-3D (Homo sapiens)	PF00071 (Ras)	5	ILE A  71 LEU A  39 VAL A 175 LEU A 179 PHE A  23	None	1.24A	4r3aB-2gf9A: undetectable	4r3aB-2gf9A: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2jgp	TYROCIDINE SYNTHETASE 3 (Brevibacillus brevis)	PF00550 (PP-binding) PF00668 (Condensation)	5	THR A 220 ILE A 226 LEU A 236 VAL A 230 MET A 123	DIO  A1525 ( 3.8A) None DIO  A1525 ( 3.8A) None None	1.17A	4r3aB-2jgpA: undetectable	4r3aB-2jgpA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2mwg	BLUE-LIGHT PHOTORECEPTOR (Bacillus subtilis)	PF01740 (STAS) PF13426 (PAS_9)	5	ASN A  61 LEU A  65 GLN A  66 VAL A  75 PHE A 119	FMN  A 900 (-2.0A) FMN  A 900 ( 4.1A) FMN  A 900 (-2.6A) None None	1.14A	4r3aB-2mwgA: 12.5	4r3aB-2mwgA: 29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2nzt	HEXOKINASE-2 (Homo sapiens)	PF00349 (Hexokinase_1) PF03727 (Hexokinase_2)	5	THR A 172 ILE A 229 ASN A 208 LEU A 168 LEU A  85	GLC  A1001 (-2.7A) GLC  A1001 (-4.2A) GLC  A1001 ( 3.0A) None None	1.49A	4r3aB-2nztA: undetectable	4r3aB-2nztA: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pr5	BLUE-LIGHT PHOTORECEPTOR (Bacillus subtilis)	PF13426 (PAS_9)	5	ASN A  61 LEU A  65 GLN A  66 VAL A  75 PHE A 119	FMN  A 500 (-3.2A) FMN  A 500 (-4.4A) FMN  A 500 (-3.1A) FMN  A 500 (-4.6A) FMN  A 500 ( 4.8A)	0.58A	4r3aB-2pr5A: 14.7	4r3aB-2pr5A: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2v4y	URIDYLATE KINASE (Escherichia coli)	PF00696 (AA_kinase)	5	GLU A  19 ASN A  59 LEU A  34 LEU A  16 MET A 220	GTP  A1243 (-2.7A) None None None None	1.38A	4r3aB-2v4yA: undetectable	4r3aB-2v4yA: 23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wkp	NPH1-1, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 (Avena sativa; Homo sapiens)	PF00071 (Ras) PF13426 (PAS_9)	5	ASN A 449 LEU A 453 GLN A 454 VAL A 463 PHE A 509	FMN  A1725 (-3.0A) FMN  A1725 (-4.2A) FMN  A1725 (-3.1A) FMN  A1725 (-4.6A) None	0.65A	4r3aB-2wkpA: 17.7	4r3aB-2wkpA: 26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xf4	HYDROXYACYLGLUTATHIO NE HYDROLASE (Salmonella enterica)	PF00753 (Lactamase_B)	5	ILE A 189 GLN A  51 VAL A 117 LEU A 124 MET A   1	None	1.48A	4r3aB-2xf4A: undetectable	4r3aB-2xf4A: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ble	CITRAMALATE SYNTHASE FROM LEPTOSPIRA INTERROGANS (Leptospira interrogans)	PF00682 (HMGL-like)	5	ILE A 289 GLU A 247 ASN A 235 LEU A  42 PHE A 321	None	1.44A	4r3aB-3bleA: undetectable	4r3aB-3bleA: 23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cai	POSSIBLE AMINOTRANSFERASE (Mycobacterium tuberculosis)	PF00266 (Aminotran_5)	5	THR A 174 ILE A 109 ASN A 118 VAL A 212 MET A 179	None	1.32A	4r3aB-3caiA: undetectable	4r3aB-3caiA: 22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3cmm	UBIQUITIN-ACTIVATING ENZYME E1 1 (Saccharomyces cerevisiae)	PF00899 (ThiF) PF09358 (E1_UFD) PF10585 (UBA_e1_thiolCys) PF16190 (E1_FCCH) PF16191 (E1_4HB)	5	THR A 540 GLU A 448 ASN A 452 LEU A 458 VAL A 502	None	1.35A	4r3aB-3cmmA: undetectable	4r3aB-3cmmA: 17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3j1c	CHAPERONIN ALPHA SUBUNIT (Acidianus tengchongensis)	PF00118 (Cpn60_TCP1)	5	THR A 517 ILE A 454 GLU A 422 LEU A 134 LEU A 429	None	1.34A	4r3aB-3j1cA: undetectable	4r3aB-3j1cA: 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3m0z	PUTATIVE ALDOLASE (Klebsiella pneumoniae)	PF07071 (KDGP_aldolase)	5	THR A 190 ILE A 213 LEU A  17 VAL A 234 LEU A 237	None	1.19A	4r3aB-3m0zA: undetectable	4r3aB-3m0zA: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3mtq	PUTATIVE PHOSPHOENOLPYRUVATE- DEPENDENT SUGAR PHOSPHOTRANSFERASE SYSTEM (PTS) PERMEASE (Klebsiella pneumoniae)	PF03610 (EIIA-man)	5	ILE A  64 LEU A  44 VAL A  52 LEU A  51 PHE A   7	None	1.48A	4r3aB-3mtqA: undetectable	4r3aB-3mtqA: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3o0r	NITRIC OXIDE REDUCTASE SUBUNIT B (Pseudomonas aeruginosa)	PF00115 (COX1)	5	ILE B 364 LEU B  63 GLN B  30 LEU B  68 PHE B  20	None None HEM  B 801 (-3.5A) None None	1.50A	4r3aB-3o0rB: undetectable	4r3aB-3o0rB: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ovz	CATHEPSIN K (Homo sapiens)	PF00112 (Peptidase_C1)	5	THR A  42 LEU A  46 VAL A  31 LEU A  34 MET A 215	None	1.38A	4r3aB-3ovzA: undetectable	4r3aB-3ovzA: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3r2u	METALLO-BETA-LACTAMA SE FAMILY PROTEIN (Staphylococcus aureus)	PF00753 (Lactamase_B)	5	ILE A 147 GLN A 239 LEU A 235 MET A 175 PHE A 146	None	1.44A	4r3aB-3r2uA: undetectable	4r3aB-3r2uA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rg1	CD180 MOLECULE (Bos taurus)	PF00560 (LRR_1) PF13855 (LRR_8)	5	ILE A 137 LEU A 127 VAL A 107 LEU A 108 MET A 116	None	1.46A	4r3aB-3rg1A: undetectable	4r3aB-3rg1A: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rg1	CD180 MOLECULE (Bos taurus)	PF00560 (LRR_1) PF13855 (LRR_8)	5	ILE A 137 VAL A 107 LEU A 108 MET A 116 PHE A 142	None	1.25A	4r3aB-3rg1A: undetectable	4r3aB-3rg1A: 20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3slc	ACETATE KINASE (Salmonella enterica)	PF00871 (Acetate_kinase)	5	THR A 331 ILE A 207 GLN A 191 VAL A 201 LEU A 204	None	1.45A	4r3aB-3slcA: undetectable	4r3aB-3slcA: 22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3tbk	RIG-I HELICASE DOMAIN (Mus musculus)	PF00271 (Helicase_C) PF04851 (ResIII)	5	THR A 378 ILE A 371 ASN A 260 LEU A 392 LEU A 364	None	1.36A	4r3aB-3tbkA: undetectable	4r3aB-3tbkA: 20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ty4	PROBABLE HOMOISOCITRATE DEHYDROGENASE (Schizosaccharomyces pombe)	PF00180 (Iso_dh)	5	ILE A  93 ASN A 105 LEU A 311 VAL A 272 PHE A  76	None	1.48A	4r3aB-3ty4A: undetectable	4r3aB-3ty4A: 23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3umm	PHOSPHORIBOSYLFORMYL GLYCINAMIDINE SYNTHASE (Salmonella enterica)	PF02769 (AIRS_C) PF13507 (GATase_5)	5	THR A 721 ILE A 734 LEU A 714 VAL A 760 LEU A 764	None	1.39A	4r3aB-3ummA: undetectable	4r3aB-3ummA: 15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3zpp	CELL WALL SURFACE ANCHOR FAMILY PROTEIN (Streptococcus pneumoniae)	PF12708 (Pectate_lyase_3) PF13229 (Beta_helix)	5	THR A 490 ILE A 508 ASN A 461 LEU A 413 VAL A 404	None	1.46A	4r3aB-3zppA: undetectable	4r3aB-3zppA: 22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4gcz	BLUE-LIGHT PHOTORECEPTOR, SENSOR PROTEIN FIXL (Bacillus subtilis; Bradyrhizobium diazoefficiens)	PF00512 (HisKA) PF02518 (HATPase_c) PF13426 (PAS_9)	5	ASN A  61 LEU A  65 GLN A  66 VAL A  75 PHE A 119	FMN  A 401 (-3.1A) FMN  A 401 (-4.5A) FMN  A 401 (-3.2A) FMN  A 401 ( 4.6A) FMN  A 401 (-4.7A)	0.70A	4r3aB-4gczA: 14.4	4r3aB-4gczA: 31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hhd	PHOTOTROPIN-1 (Arabidopsis thaliana)	PF13426 (PAS_9)	5	ASN A 511 LEU A 515 GLN A 516 VAL A 525 PHE A 571	FMN  A 701 (-2.9A) FMN  A 701 (-4.4A) FMN  A 701 (-3.3A) FMN  A 701 (-4.9A) FMN  A 701 (-4.9A)	0.66A	4r3aB-4hhdA: 16.8	4r3aB-4hhdA: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hj3	LOV PROTEIN (Rhodobacter sphaeroides)	PF13426 (PAS_9)	5	THR A  21 ASN A  54 LEU A  58 GLN A  59 PHE A 114	FMN  A 201 (-4.4A) FMN  A 201 (-3.1A) FMN  A 201 (-4.4A) FMN  A 201 (-3.6A) None	0.43A	4r3aB-4hj3A: 13.9	4r3aB-4hj3A: 24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jkl	BETA-GLUCURONIDASE (Streptococcus agalactiae)	PF00703 (Glyco_hydro_2) PF02836 (Glyco_hydro_2_C) PF02837 (Glyco_hydro_2_N)	5	ILE A 442 GLU A 408 ASN A 407 LEU A 136 PHE A 357	None	1.29A	4r3aB-4jklA: undetectable	4r3aB-4jklA: 19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4m6w	FANCONI ANEMIA GROUP M PROTEIN FANCONI ANEMIA-ASSOCIATED PROTEIN OF 24 KDA (Homo sapiens)	PF02732 (ERCC4) PF12826 (HHH_2)	5	THR B 108 ILE A1932 LEU B  59 VAL B 129 PHE A1934	None	1.40A	4r3aB-4m6wB: undetectable	4r3aB-4m6wB: 22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ovy	HALOACID DEHALOGENASE DOMAIN PROTEIN HYDROLASE (Planctopirus limnophila)	PF12710 (HAD)	5	THR A 283 GLU A  73 ASN A 257 LEU A 304 PHE A 289	None CA  A 409 ( 4.1A) CA  A 409 (-2.8A) None None	1.38A	4r3aB-4ovyA: undetectable	4r3aB-4ovyA: 23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4q0g	PROBABLE ACETYL-/PROPIONYL-CO A CARBOXYLASE (BETA SUBUNIT) ACCD1 (Mycobacterium tuberculosis)	PF01039 (Carboxyl_trans)	5	THR A 503 ILE A 497 LEU A 367 GLN A 368 LEU A 428	None	1.33A	4r3aB-4q0gA: undetectable	4r3aB-4q0gA: 22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4r38	BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2 (Erythrobacter litoralis)	PF13426 (PAS_9)	10	THR A  21 ILE A  25 GLU A  30 ASN A  54 LEU A  58 GLN A  59 VAL A  68 LEU A  71 MET A 101 PHE A 114	RBF  A 201 (-3.1A) None None RBF  A 201 (-2.6A) RBF  A 201 (-3.9A) RBF  A 201 (-3.0A) RBF  A 201 (-3.3A) RBF  A 201 ( 3.6A) RBF  A 201 (-3.2A) RBF  A 201 (-4.4A)	0.59A	4r3aB-4r38A: 16.8	4r3aB-4r38A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4r38	BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2 (Erythrobacter litoralis)	PF13426 (PAS_9)	5	THR A  21 ILE A  75 LEU A  58 MET A 101 PHE A 114	RBF  A 201 (-3.1A) RBF  A 201 (-4.2A) RBF  A 201 (-3.9A) RBF  A 201 (-3.2A) RBF  A 201 (-4.4A)	1.42A	4r3aB-4r38A: 16.8	4r3aB-4r38A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ri2	PHOTOSYSTEM II 22 KDA PROTEIN, CHLOROPLASTIC (Spinacia oleracea)	PF00504 (Chloroa_b-bind)	5	THR A 174 ILE A 178 GLU A 182 VAL A 189 LEU A  52	None	1.40A	4r3aB-4ri2A: undetectable	4r3aB-4ri2A: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wuj	GLYCOSIDE HYDROLASE FAMILY 15, CELLULOSE SIGNALING ASSOCIATED PROTEIN ENVOY (Trichoderma reesei)	PF13426 (PAS_9)	6	THR A 101 ILE A 105 ASN A 134 LEU A 138 GLN A 139 VAL A 154	FMN  A5201 (-3.4A) None FMN  A5201 (-2.5A) FMN  A5201 (-3.7A) FMN  A5201 (-3.1A) FMN  A5201 (-3.6A)	0.65A	4r3aB-4wujA: 12.2	4r3aB-4wujA: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5a8b	PTAUREO1A LOV2 DOMAIN (Phaeodactylum tricornutum)	PF13426 (PAS_9)	5	ASN A 286 LEU A 290 GLN A 291 VAL A 300 PHE A 346	FMN  A 500 (-3.2A) FMN  A 500 (-4.0A) FMN  A 500 (-3.0A) None FMN  A 500 (-4.8A)	0.78A	4r3aB-5a8bA: 14.0	4r3aB-5a8bA: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5cwv	NUCLEOPORIN NUP192 (Chaetomium thermophilum)	PF11894 (Nup192)	5	GLU A1545 LEU A1584 VAL A1536 LEU A1535 MET A1495	None	1.35A	4r3aB-5cwvA: undetectable	4r3aB-5cwvA: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dju	NPH1-2 (Avena sativa)	PF13426 (PAS_9)	5	ASN A 449 LEU A 453 GLN A 454 VAL A 463 PHE A 509	FMN  A 601 ( 3.1A) FMN  A 601 (-4.0A) FMN  A 601 (-3.1A) FMN  A 601 (-4.6A) None	0.63A	4r3aB-5djuA: 17.9	4r3aB-5djuA: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5gqf	LACTO-N-BIOSIDASE (Bifidobacterium longum)	no annotation	5	THR A 159 ILE A 103 ASN A  76 VAL A  51 LEU A  90	None	1.43A	4r3aB-5gqfA: undetectable	4r3aB-5gqfA: 19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hb0	NUCLEOPORIN NUP170 (Chaetomium thermophilum)	no annotation	5	THR B1242 ILE B1170 GLN B1234 LEU B1189 PHE B1171	None	1.38A	4r3aB-5hb0B: undetectable	4r3aB-5hb0B: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hb1	NUCLEOPORIN NUP170 (Chaetomium thermophilum)	PF03177 (Nucleoporin_C)	5	THR A1242 ILE A1170 GLN A1234 LEU A1189 PHE A1171	None	1.48A	4r3aB-5hb1A: undetectable	4r3aB-5hb1A: 18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hzh	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1,NPH1-1,RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 (Avena sativa; Homo sapiens)	PF00071 (Ras) PF13426 (PAS_9)	5	ASN A  96 LEU A 100 GLN A 101 VAL A 110 PHE A 156	FMN  A 402 (-3.2A) FMN  A 402 (-4.1A) FMN  A 402 (-2.9A) FMN  A 402 (-4.5A) FMN  A 402 (-4.9A)	0.59A	4r3aB-5hzhA: 18.2	4r3aB-5hzhA: 26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hzk	INTERSECTIN-1,NPH1-1 ,INTERSECTIN-1 (Avena sativa; Homo sapiens)	PF00621 (RhoGEF) PF13426 (PAS_9) PF16652 (PH_13)	5	ASN B1354 LEU B1358 GLN B1359 VAL B1368 PHE B1414	FMN  B1801 (-3.0A) FMN  B1801 (-4.2A) FMN  B1801 (-3.0A) FMN  B1801 (-4.5A) FMN  B1801 (-4.8A)	0.66A	4r3aB-5hzkB: 18.1	4r3aB-5hzkB: 26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5it3	LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A (Homo sapiens)	PF04433 (SWIRM)	5	THR A 234 ILE A 227 ASN A 263 LEU A 256 LEU A 222	None	1.40A	4r3aB-5it3A: undetectable	4r3aB-5it3A: 12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5k1c	WD REPEAT-CONTAINING PROTEIN 48 (Homo sapiens)	PF00400 (WD40)	5	THR B 115 ILE B 141 LEU B 149 VAL B  82 LEU B 123	None	1.49A	4r3aB-5k1cB: undetectable	4r3aB-5k1cB: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5oom	ACYL CARRIER PROTEIN, MITOCHONDRIAL MIEF1 UPSTREAM OPEN READING FRAME PROTEIN (Homo sapiens)	PF00467 (KOW) PF01016 (Ribosomal_L27) PF17136 (ribosomal_L24)	5	ILE v  35 LEU w 110 GLN w 115 LEU v  10 PHE v  39	None	1.22A	4r3aB-5oomv: undetectable	4r3aB-5oomv: 13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5svw	ADAGIO PROTEIN 1 (Arabidopsis thaliana)	no annotation	5	ILE B 122 ASN B  53 LEU B  57 GLN B  58 VAL B  76	FMN  B5201 (-3.1A) FMN  B5201 (-2.9A) FMN  B5201 (-3.7A) FMN  B5201 (-3.1A) FMN  B5201 (-3.8A)	1.00A	4r3aB-5svwB: 13.9	4r3aB-5svwB: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u4h	UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE (Acinetobacter baumannii)	PF00275 (EPSP_synthase)	5	THR A 252 ILE A 234 LEU A 410 VAL A 378 LEU A 379	None	1.44A	4r3aB-5u4hA: undetectable	4r3aB-5u4hA: 23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5u9p	GLUCONATE 5-DEHYDROGENASE (Burkholderia cenocepacia)	PF13561 (adh_short_C2)	5	ILE A 144 ASN A  96 LEU A 198 VAL A 224 LEU A 227	None NAP  A 301 (-3.3A) NAP  A 301 ( 3.5A) None None	1.30A	4r3aB-5u9pA: undetectable	4r3aB-5u9pA: 25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5veh	KYNURENINE AMINOTRANSFERASE (Aedes aegypti)	no annotation	5	THR A 256 GLU A 222 LEU A  86 VAL A  94 LEU A  93	LLP  A 255 ( 4.4A) None None None None	1.08A	4r3aB-5vehA: undetectable	4r3aB-5vehA: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5wna	MAB 3D3 FAB HEAVY CHAIN MAJOR SURFACE GLYCOPROTEIN G (Homo sapiens; Human orthopneumovirus)	no annotation	5	ILE B 189 GLU H  30 ASN H  74 LEU H  79 LEU H  27	None	1.26A	4r3aB-5wnaB: undetectable	4r3aB-5wnaB: 5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5wsl	KERATINASE (Meiothermus taiwanensis)	no annotation	5	THR A 177 ILE A 147 LEU A 139 MET A 129 PHE A 153	CA  A 302 (-3.5A) None None None None	1.24A	4r3aB-5wslA: undetectable	4r3aB-5wslA: 21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6gbv	PUTATIVE BLUE-LIGHT PHOTORECEPTOR (Dinoroseobacter shibae)	no annotation	5	ASN A  71 LEU A  75 GLN A  76 VAL A  85 PHE A 131	FMN  A 500 ( 3.2A) FMN  A 500 (-4.0A) FMN  A 500 (-4.2A) FMN  A 500 (-4.3A) FMN  A 500 (-4.8A)	1.03A	4r3aB-6gbvA: 14.8	4r3aB-6gbvA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1jnu	PHY3 PROTEIN (Adiantum capillus-veneris)	PF13426 (PAS_9)	6	CYH A 966 ARG A 967 ASN A 998 ASN A1008 GLY A1027 GLN A1029	FMN  A1033 (-1.8A) FMN  A1033 (-3.6A) FMN  A1033 (-3.2A) FMN  A1033 (-4.1A) FMN  A1033 (-3.7A) FMN  A1033 (-4.2A)	0.50A	4r3aB-1jnuA: 15.7	4r3aB-1jnuA: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1n9l	PUTATIVE BLUE LIGHT RECEPTOR (Chlamydomonas reinhardtii)	PF13426 (PAS_9)	10	ALA A  25 LEU A  34 CYH A  57 ARG A  58 ILE A  77 ASN A  89 ASN A  99 LEU A 101 GLY A 118 GLN A 120	FMN  A 500 ( 3.7A) None FMN  A 500 (-3.4A) FMN  A 500 (-4.0A) FMN  A 500 (-4.7A) FMN  A 500 (-3.0A) FMN  A 500 (-3.9A) FMN  A 500 (-4.1A) FMN  A 500 (-3.9A) FMN  A 500 (-3.7A)	0.44A	4r3aB-1n9lA: 15.6	4r3aB-1n9lA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1q1p	EPITHELIAL-CADHERIN (Mus musculus)	PF00028 (Cadherin)	5	LEU A  66 ILE A  52 ILE A  94 LEU A  76 GLY A  42	None	1.02A	4r3aB-1q1pA: undetectable	4r3aB-1q1pA: 20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1qhg	ATP-DEPENDENT HELICASE PCRA (Geobacillus stearothermophilus)	PF00580 (UvrD-helicase) PF13361 (UvrD_C)	5	ALA A 248 ILE A 280 LEU A 282 GLY A  36 GLN A  16	None None None ATP  A 726 (-3.4A) ATP  A 726 (-3.3A)	0.97A	4r3aB-1qhgA: undetectable	4r3aB-1qhgA: 21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1qhh	PROTEIN (PCRA (SUBUNIT)) (Geobacillus stearothermophilus)	PF00580 (UvrD-helicase) PF13361 (UvrD_C)	5	ALA B 248 ILE B 280 LEU B 282 GLY A  36 GLN A  16	None None None ATP  A 700 (-3.4A) ATP  A 700 (-2.8A)	0.94A	4r3aB-1qhhB: undetectable	4r3aB-1qhhB: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1uaq	CYTOSINE DEAMINASE (Saccharomyces cerevisiae)	PF00383 (dCMP_cyt_deam_1)	5	CYH A  71 ILE A  65 ILE A 103 LEU A  84 GLY A  35	None	0.89A	4r3aB-1uaqA: undetectable	4r3aB-1uaqA: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ufr	PYR MRNA-BINDING ATTENUATION PROTEIN (Thermus thermophilus)	PF00156 (Pribosyltran)	5	ALA A 115 LEU A 119 ALA A 145 ILE A  24 GLY A  38	None	0.97A	4r3aB-1ufrA: undetectable	4r3aB-1ufrA: 21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1vhk	HYPOTHETICAL PROTEIN YQEU (Bacillus subtilis)	PF04452 (Methyltrans_RNA)	5	LEU A 227 ALA A 105 ILE A  83 ILE A  79 LEU A 199	None	1.02A	4r3aB-1vhkA: undetectable	4r3aB-1vhkA: 21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wuf	HYPOTHETICAL PROTEIN LIN2664 (Listeria innocua)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	5	LEU A1262 ALA A1121 ILE A1124 LEU A1106 GLY A1269	None	0.97A	4r3aB-1wufA: undetectable	4r3aB-1wufA: 22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1wuu	GALACTOKINASE (Homo sapiens)	PF00288 (GHMP_kinases_N) PF08544 (GHMP_kinases_C) PF10509 (GalKase_gal_bdg)	5	ALA A 387 ALA A 164 ILE A 163 ILE A 201 LEU A 199	None	1.01A	4r3aB-1wuuA: undetectable	4r3aB-1wuuA: 24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ybw	HEPATOCYTE GROWTH FACTOR ACTIVATOR PRECURSOR (Homo sapiens)	PF00089 (Trypsin)	5	ALA A 584 LEU A 561 ALA A 538 ILE A 537 ILE A 520	None	0.99A	4r3aB-1ybwA: undetectable	4r3aB-1ybwA: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2g5c	PREPHENATE DEHYDROGENASE (Aquifex aeolicus)	PF02153 (PDH)	5	ALA A 222 LEU A 223 ALA A 273 ILE A 274 LEU A 281	None	1.02A	4r3aB-2g5cA: undetectable	4r3aB-2g5cA: 20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2hes	YDR267CP (Saccharomyces cerevisiae)	PF00400 (WD40)	5	ALA X  28 LEU X  27 ALA X 114 ASN X 255 GLY X  30	None	0.90A	4r3aB-2hesX: undetectable	4r3aB-2hesX: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ji9	OXALYL-COA DECARBOXYLASE (Oxalobacter formigenes)	PF00205 (TPP_enzyme_M) PF02775 (TPP_enzyme_C) PF02776 (TPP_enzyme_N)	5	LEU A 103 CYH A  76 ALA A  40 ILE A  36 GLY A  83	None	0.96A	4r3aB-2ji9A: undetectable	4r3aB-2ji9A: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2jnk	HYALURONONGLUCOSAMIN IDASE (Clostridium perfringens)	PF00404 (Dockerin_1) PF07554 (FIVAR)	6	ILE A  90 ILE A 118 ASN A 101 ASN A 107 LEU A 110 GLY A  86	None	1.38A	4r3aB-2jnkA: undetectable	4r3aB-2jnkA: 16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2mwg	BLUE-LIGHT PHOTORECEPTOR (Bacillus subtilis)	PF01740 (STAS) PF13426 (PAS_9)	7	CYH A  62 ARG A  63 ASN A  94 ASN A 104 LEU A 106 GLY A 121 GLN A 123	FMN  A 900 (-3.3A) FMN  A 900 (-4.9A) FMN  A 900 (-2.9A) FMN  A 900 (-3.9A) FMN  A 900 (-4.3A) FMN  A 900 (-2.9A) FMN  A 900 (-4.2A)	1.09A	4r3aB-2mwgA: 12.5	4r3aB-2mwgA: 29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2mwg	BLUE-LIGHT PHOTORECEPTOR (Bacillus subtilis)	PF01740 (STAS) PF13426 (PAS_9)	7	CYH A  62 ILE A  92 ASN A  94 ASN A 104 LEU A 106 GLY A 121 GLN A 123	FMN  A 900 (-3.3A) FMN  A 900 ( 4.1A) FMN  A 900 (-2.9A) FMN  A 900 (-3.9A) FMN  A 900 (-4.3A) FMN  A 900 (-2.9A) FMN  A 900 (-4.2A)	0.60A	4r3aB-2mwgA: 12.5	4r3aB-2mwgA: 29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2o56	PUTATIVE MANDELATE RACEMASE (Salmonella enterica)	PF02746 (MR_MLE_N) PF13378 (MR_MLE_C)	5	ALA A 330 ALA A 103 ILE A 102 ILE A  10 GLY A 325	None	1.02A	4r3aB-2o56A: undetectable	4r3aB-2o56A: 22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pjr	PROTEIN (HELICASE PCRA) (Geobacillus stearothermophilus)	PF00580 (UvrD-helicase) PF13361 (UvrD_C)	5	ALA A 248 ILE A 280 LEU A 282 GLY A  36 GLN A  16	None	1.01A	4r3aB-2pjrA: undetectable	4r3aB-2pjrA: 22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2pr5	BLUE-LIGHT PHOTORECEPTOR (Bacillus subtilis)	PF13426 (PAS_9)	8	CYH A  62 ARG A  63 ILE A  92 ASN A  94 ASN A 104 LEU A 106 GLY A 121 GLN A 123	FMN  A 500 (-3.5A) FMN  A 500 (-3.8A) FMN  A 500 ( 4.6A) FMN  A 500 (-3.1A) FMN  A 500 (-3.7A) FMN  A 500 (-4.1A) FMN  A 500 (-3.9A) FMN  A 500 (-3.9A)	0.47A	4r3aB-2pr5A: 14.7	4r3aB-2pr5A: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2r0l	HEPATOCYTE GROWTH FACTOR ACTIVATOR (Homo sapiens)	PF00089 (Trypsin)	5	ALA A 183 LEU A 162 ALA A 139 ILE A 138 ILE A 121	None	0.96A	4r3aB-2r0lA: undetectable	4r3aB-2r0lA: 20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wkp	NPH1-1, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 (Avena sativa; Homo sapiens)	PF00071 (Ras) PF13426 (PAS_9)	6	ARG A 451 ILE A 470 ASN A 482 ASN A 492 GLY A 511 GLN A 513	FMN  A1725 (-3.8A) FMN  A1725 (-4.7A) FMN  A1725 (-3.0A) FMN  A1725 (-3.8A) FMN  A1725 (-3.7A) FMN  A1725 (-3.8A)	0.41A	4r3aB-2wkpA: 17.7	4r3aB-2wkpA: 26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2wkp	NPH1-1, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 (Avena sativa; Homo sapiens)	PF00071 (Ras) PF13426 (PAS_9)	6	CYH A 450 ARG A 451 ILE A 470 ASN A 492 GLY A 511 GLN A 513	FMN  A1725 (-3.4A) FMN  A1725 (-3.8A) FMN  A1725 (-4.7A) FMN  A1725 (-3.8A) FMN  A1725 (-3.7A) FMN  A1725 (-3.8A)	0.86A	4r3aB-2wkpA: 17.7	4r3aB-2wkpA: 26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2xax	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE 1 SUBUNIT ALPHA (Escherichia coli)	PF00317 (Ribonuc_red_lgN) PF02867 (Ribonuc_red_lgC) PF03477 (ATP-cone)	5	ALA A 302 LEU A 438 ALA A 243 ILE A 244 GLY A 300	None	1.02A	4r3aB-2xaxA: undetectable	4r3aB-2xaxA: 20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ywj	GLUTAMINE AMIDOTRANSFERASE SUBUNIT PDXT (Methanocaldococcus jannaschii)	PF01174 (SNO)	5	LEU A  92 ALA A   7 ILE A   8 ILE A  38 LEU A  35	None	0.96A	4r3aB-2ywjA: undetectable	4r3aB-2ywjA: 18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2z6c	PHOTOTROPIN-1 (Arabidopsis thaliana)	PF13426 (PAS_9)	8	CYH A 234 ARG A 235 ILE A 264 ASN A 266 ASN A 276 LEU A 278 GLY A 295 GLN A 297	FMN  A 500 (-3.4A) FMN  A 500 (-3.9A) None FMN  A 500 (-3.0A) FMN  A 500 (-3.6A) FMN  A 500 (-4.3A) FMN  A 500 (-3.9A) FMN  A 500 (-3.6A)	0.69A	4r3aB-2z6cA: 14.6	4r3aB-2z6cA: 17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2z6d	PHOTOTROPIN-2 (Arabidopsis thaliana)	PF13426 (PAS_9)	7	CYH A 170 ARG A 171 ASN A 202 ASN A 212 LEU A 214 GLY A 231 GLN A 233	FMN  A 500 (-3.5A) FMN  A 500 (-3.7A) FMN  A 500 (-3.1A) FMN  A 500 (-3.7A) FMN  A 500 (-4.3A) FMN  A 500 (-3.7A) FMN  A 500 (-3.8A)	0.48A	4r3aB-2z6dA: 14.9	4r3aB-2z6dA: 16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2zcx	TETR-FAMILY TRANSCRIPTIONAL REGULATOR (Streptomyces coelicolor)	PF00440 (TetR_N)	6	LEU A  90 ARG A 154 ILE A 168 ILE A 220 LEU A 217 GLY A 102	None	1.27A	4r3aB-2zcxA: undetectable	4r3aB-2zcxA: 23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3clk	TRANSCRIPTION REGULATOR (Lactobacillus plantarum)	PF13377 (Peripla_BP_3)	5	ALA A 210 ILE A 211 ILE A 174 ASN A 171 GLY A 199	None	1.00A	4r3aB-3clkA: undetectable	4r3aB-3clkA: 22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3eu8	PUTATIVE GLUCOAMYLASE (Bacteroides fragilis)	PF10091 (Glycoamylase) PF11329 (DUF3131)	6	ALA A  65 LEU A  64 ILE A  95 ILE A 184 LEU A 163 GLY A  89	EDO  A 474 (-3.6A) None None None None None	1.40A	4r3aB-3eu8A: undetectable	4r3aB-3eu8A: 22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3grk	ENOYL-(ACYL-CARRIER- PROTEIN) REDUCTASE (NADH) (Brucella melitensis)	PF13561 (adh_short_C2)	5	ALA A  32 LEU A   8 ILE A  15 ILE A 144 GLY A 232	None	0.83A	4r3aB-3grkA: undetectable	4r3aB-3grkA: 23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3j0a	TOLL-LIKE RECEPTOR 5 (Homo sapiens)	PF01582 (TIR) PF13855 (LRR_8)	5	LEU A 341 ILE A 372 ASN A 394 ASN A 370 LEU A 347	None	0.99A	4r3aB-3j0aA: undetectable	4r3aB-3j0aA: 16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3p7n	SENSOR HISTIDINE KINASE (Erythrobacter litoralis)	PF00196 (GerE) PF13426 (PAS_9)	8	LEU A  52 CYH A  75 ARG A  76 ILE A 105 ASN A 107 ASN A 117 GLY A 136 GLN A 138	None FMN  A 500 (-3.3A) FMN  A 500 (-3.8A) FMN  A 500 (-4.1A) FMN  A 500 (-3.1A) FMN  A 500 (-4.1A) FMN  A 500 ( 4.0A) FMN  A 500 (-3.9A)	0.51A	4r3aB-3p7nA: 14.5	4r3aB-3p7nA: 24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3q13	SPONDIN-1 (Homo sapiens)	PF06468 (Spond_N)	5	ALA A 401 LEU A 350 ALA A 233 ILE A 283 LEU A 209	None	0.88A	4r3aB-3q13A: undetectable	4r3aB-3q13A: 21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3q2w	CADHERIN-2 (Mus musculus)	PF00028 (Cadherin)	5	LEU A  66 ILE A  52 ILE A  94 LEU A  76 GLY A  42	None	0.98A	4r3aB-3q2wA: undetectable	4r3aB-3q2wA: 21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3q60	ROP5B (Toxoplasma gondii)	PF14531 (Kinase-like)	5	ARG A 480 ALA A 435 LEU A 444 GLY A 388 GLN A 448	None	0.99A	4r3aB-3q60A: undetectable	4r3aB-3q60A: 23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3rh8	VIVID PAS PROTEIN VVD (Neurospora crassa)	PF13426 (PAS_9)	8	CYH B 108 ARG B 109 ILE B 139 ASN B 151 ASN B 161 LEU B 163 GLY B 180 GLN B 182	FAD  B5201 (-1.8A) FAD  B5201 (-4.3A) FAD  B5201 (-4.6A) FAD  B5201 (-3.0A) FAD  B5201 (-3.7A) FAD  B5201 (-3.8A) FAD  B5201 (-3.8A) FAD  B5201 (-4.1A)	0.60A	4r3aB-3rh8B: 12.5	4r3aB-3rh8B: 17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3t50	BLUE-LIGHT-ACTIVATED HISTIDINE KINASE (Brucella melitensis)	PF13426 (PAS_9)	6	ALA A  84 ILE A  99 ASN A 101 ASN A 111 LEU A 113 GLN A 132	None FMN  A 200 ( 4.4A) FMN  A 200 (-3.1A) FMN  A 200 (-3.8A) FMN  A 200 (-4.3A) FMN  A 200 (-3.9A)	1.22A	4r3aB-3t50A: 15.5	4r3aB-3t50A: 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3t50	BLUE-LIGHT-ACTIVATED HISTIDINE KINASE (Brucella melitensis)	PF13426 (PAS_9)	8	CYH A  69 ARG A  70 ILE A  89 ILE A  99 ASN A 101 ASN A 111 LEU A 113 GLN A 132	FMN  A 200 (-3.4A) FMN  A 200 (-3.9A) FMN  A 200 (-4.5A) FMN  A 200 ( 4.4A) FMN  A 200 (-3.1A) FMN  A 200 (-3.8A) FMN  A 200 (-4.3A) FMN  A 200 (-3.9A)	0.73A	4r3aB-3t50A: 15.5	4r3aB-3t50A: 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3u4c	BACILYSIN BIOSYNTHESIS OXIDOREDUCTASE YWFH (Bacillus subtilis)	PF13561 (adh_short_C2)	5	ALA A 237 ALA A  18 ILE A  19 ILE A  47 LEU A  30	None	0.96A	4r3aB-3u4cA: undetectable	4r3aB-3u4cA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ue6	AUREOCHROME1 (Vaucheria frigida)	PF13426 (PAS_9)	6	ARG A 255 ILE A 274 ASN A 286 ASN A 296 GLY A 315 GLN A 317	FMN  A 500 (-3.6A) FMN  A 500 (-4.9A) FMN  A 500 (-3.3A) FMN  A 500 (-4.3A) FMN  A 500 (-3.7A) FMN  A 500 (-4.1A)	0.57A	4r3aB-3ue6A: 15.1	4r3aB-3ue6A: 19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ue6	AUREOCHROME1 (Vaucheria frigida)	PF13426 (PAS_9)	6	CYH A 254 ARG A 255 ILE A 274 ASN A 296 GLY A 315 GLN A 317	FMN  A 500 (-3.5A) FMN  A 500 (-3.6A) FMN  A 500 (-4.9A) FMN  A 500 (-4.3A) FMN  A 500 (-3.7A) FMN  A 500 (-4.1A)	0.85A	4r3aB-3ue6A: 15.1	4r3aB-3ue6A: 19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3w21	PUTATIVE UNCHARACTERIZED PROTEIN (Burkholderia ambifaria)	no annotation	5	ALA A  24 ILE A  27 ILE A  42 LEU A 237 GLY A 180	None	0.85A	4r3aB-3w21A: undetectable	4r3aB-3w21A: 19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3wj2	CARBOXYLESTERASE (Ferroplasma acidiphilum)	PF07859 (Abhydrolase_3)	5	ALA A 153 ALA A 103 ILE A 110 LEU A 308 GLY A 151	None	0.99A	4r3aB-3wj2A: undetectable	4r3aB-3wj2A: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4af0	INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE (Cryptococcus neoformans)	PF00478 (IMPDH) PF00571 (CBS)	5	ALA B  73 ALA B 262 ILE B 108 ILE B 304 GLY B 334	None	0.92A	4r3aB-4af0B: undetectable	4r3aB-4af0B: 21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4cby	HISTONE DEACETYLASE 4 (Homo sapiens)	PF00850 (Hist_deacetyl)	5	ALA A 935 LEU A 948 ALA A 893 ASN A1010 GLY A 945	None	1.00A	4r3aB-4cbyA: undetectable	4r3aB-4cbyA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4crm	TRANSLATION INITIATION FACTOR RLI1 (Saccharomyces cerevisiae)	PF00005 (ABC_tran) PF00037 (Fer4) PF04068 (RLI)	5	ALA P   9 ILE P  10 ASN P  78 LEU P  79 GLY P 302	None	0.99A	4r3aB-4crmP: undetectable	4r3aB-4crmP: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4cza	NA+/H+ ANTIPORTER, PUTATIVE (Pyrococcus abyssi)	PF00999 (Na_H_Exchanger)	5	ALA A 169 LEU A 173 ALA A 370 ILE A 125 GLY A 119	None	0.98A	4r3aB-4czaA: undetectable	4r3aB-4czaA: 23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4e69	2-DEHYDRO-3-DEOXYGLU CONOKINASE (Oceanicola granulosus)	PF00294 (PfkB)	5	ALA A 147 LEU A 116 ALA A 159 ILE A 158 LEU A 133	None	0.95A	4r3aB-4e69A: undetectable	4r3aB-4e69A: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ees	PHOTOTROPIN-2 (Arabidopsis thaliana)	PF13426 (PAS_9)	7	ARG A 427 ILE A 446 ASN A 458 ASN A 468 LEU A 470 GLY A 487 GLN A 489	FMN  A1001 (-3.8A) FMN  A1001 (-4.6A) FMN  A1001 (-3.0A) FMN  A1001 (-3.9A) FMN  A1001 (-4.2A) FMN  A1001 (-3.8A) FMN  A1001 (-3.9A)	0.44A	4r3aB-4eesA: 15.8	4r3aB-4eesA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4f92	U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE (Homo sapiens)	PF00270 (DEAD) PF00271 (Helicase_C) PF02889 (Sec63)	5	ALA B 471 ARG B 558 ALA B 513 ILE B 585 GLY B 522	None	1.02A	4r3aB-4f92B: undetectable	4r3aB-4f92B: 11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4fsf	PENICILLIN-BINDING PROTEIN 3 (Pseudomonas aeruginosa)	PF00905 (Transpeptidase) PF03717 (PBP_dimer)	5	ALA A 306 ALA A 358 ILE A 361 ILE A 345 LEU A 342	None	0.94A	4r3aB-4fsfA: 3.5	4r3aB-4fsfA: 23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4gcz	BLUE-LIGHT PHOTORECEPTOR, SENSOR PROTEIN FIXL (Bacillus subtilis; Bradyrhizobium diazoefficiens)	PF00512 (HisKA) PF02518 (HATPase_c) PF13426 (PAS_9)	8	CYH A  62 ARG A  63 ILE A  92 ASN A  94 ASN A 104 LEU A 106 GLY A 121 GLN A 123	FMN  A 401 (-3.3A) FMN  A 401 (-3.9A) FMN  A 401 ( 4.6A) FMN  A 401 (-3.1A) FMN  A 401 (-3.7A) FMN  A 401 (-4.3A) FMN  A 401 (-3.7A) FMN  A 401 (-3.8A)	0.72A	4r3aB-4gczA: 14.4	4r3aB-4gczA: 31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hhd	PHOTOTROPIN-1 (Arabidopsis thaliana)	PF13426 (PAS_9)	7	CYH A 512 ARG A 513 ILE A 532 ASN A 544 ASN A 554 GLY A 573 GLN A 575	FMN  A 701 (-3.7A) FMN  A 701 (-2.6A) FMN  A 701 (-4.7A) FMN  A 701 (-2.8A) FMN  A 701 (-3.8A) FMN  A 701 (-3.7A) FMN  A 701 (-3.6A)	0.75A	4r3aB-4hhdA: 16.8	4r3aB-4hhdA: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4hj3	LOV PROTEIN (Rhodobacter sphaeroides)	PF13426 (PAS_9)	8	LEU A  32 CYH A  55 ARG A  56 ASN A  87 ASN A  97 LEU A  99 GLY A 116 GLN A 118	None FMN  A 201 (-3.7A) FMN  A 201 (-3.4A) FMN  A 201 (-2.9A) FMN  A 201 (-3.8A) FMN  A 201 (-4.4A) FMN  A 201 (-3.9A) FMN  A 201 (-3.8A)	0.78A	4r3aB-4hj3A: 13.9	4r3aB-4hj3A: 24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4lb8	UNCHARACTERIZED PROTEIN (Bacteroides thetaiotaomicron)	PF16140 (DUF4848)	5	ALA A 214 LEU A 205 ALA A 265 ILE A 266 GLY A 280	None None None PEG  A 406 (-4.6A) None	0.98A	4r3aB-4lb8A: undetectable	4r3aB-4lb8A: 23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4mbu	SIMILAR TO N-ACETYLTRANSFERASE (Staphylococcus aureus)	PF13420 (Acetyltransf_4)	5	ALA A 155 LEU A 154 ALA A 125 ILE A 127 ILE A  84	None	1.02A	4r3aB-4mbuA: undetectable	4r3aB-4mbuA: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4mp3	PUTATIVE ORNITHINE CYCLODEAMINASE (Staphylococcus aureus)	PF02423 (OCD_Mu_crystall)	5	ALA A  27 ALA A  73 ILE A  68 ILE A 110 LEU A 101	None	0.98A	4r3aB-4mp3A: undetectable	4r3aB-4mp3A: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4nuq	CADHERIN-2 (Mus musculus)	PF00028 (Cadherin)	5	LEU A  66 ILE A  52 ILE A  94 LEU A  76 GLY A  42	None	1.01A	4r3aB-4nuqA: undetectable	4r3aB-4nuqA: 20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4oou	BETA-1,4-MANNANASE (Cryptopygus antarcticus)	no annotation	5	ALA B 266 ILE B 222 ILE B 156 ASN B 153 LEU B 152	None	1.02A	4r3aB-4oouB: undetectable	4r3aB-4oouB: 21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4oqj	PKS (Streptomyces albus)	PF00109 (ketoacyl-synt) PF02801 (Ketoacyl-synt_C) PF16197 (KAsynt_C_assoc)	5	ALA A 200 ALA A  21 ILE A  20 ILE A 382 LEU A 378	None	0.99A	4r3aB-4oqjA: undetectable	4r3aB-4oqjA: 18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4p05	ARYLSULFATE SULFOTRANSFERASE ASST (Escherichia coli)	PF05935 (Arylsulfotrans) PF17425 (Arylsulfotran_N)	5	LEU A 316 ALA A 392 ASN A 358 ASN A 436 GLY A 452	None None 4NS  A 601 (-3.6A) 4NS  A 601 (-3.3A) None	0.87A	4r3aB-4p05A: undetectable	4r3aB-4p05A: 20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4q66	PROTEIN BCH1 (Saccharomyces cerevisiae)	no annotation	5	LEU K 551 ALA K 480 ILE K 395 GLY K 589 GLN K 489	None	0.85A	4r3aB-4q66K: undetectable	4r3aB-4q66K: 18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4r38	BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2 (Erythrobacter litoralis)	PF13426 (PAS_9)	7	ALA A  23 LEU A  32 CYH A  55 ALA A  72 ILE A  75 ILE A  85 ASN A  87	RBF  A 201 ( 3.4A) None RBF  A 201 (-3.3A) RBF  A 201 ( 3.3A) RBF  A 201 (-4.2A) RBF  A 201 ( 4.2A) RBF  A 201 (-2.4A)	1.33A	4r3aB-4r38A: 16.8	4r3aB-4r38A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4r38	BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2 (Erythrobacter litoralis)	PF13426 (PAS_9)	12	ALA A  23 LEU A  32 CYH A  55 ARG A  56 ALA A  72 ILE A  75 ILE A  85 ASN A  87 ASN A  97 LEU A  99 GLY A 116 GLN A 118	RBF  A 201 ( 3.4A) None RBF  A 201 (-3.3A) RBF  A 201 (-3.7A) RBF  A 201 ( 3.3A) RBF  A 201 (-4.2A) RBF  A 201 ( 4.2A) RBF  A 201 (-2.4A) RBF  A 201 (-3.7A) RBF  A 201 (-4.2A) RBF  A 201 ( 3.3A) RBF  A 201 (-4.0A)	0.48A	4r3aB-4r38A: 16.8	4r3aB-4r38A: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4r38	BLUE-LIGHT-ACTIVATED HISTIDINE KINASE 2 (Erythrobacter litoralis)	PF13426 (PAS_9)	6	ALA A  23 LEU A  32 CYH A  55 ARG A  56 ILE A  75 ASN A  97	RBF  A 201 ( 3.4A) None RBF  A 201 (-3.3A) RBF  A 201 (-3.7A) RBF  A 201 (-4.2A) RBF  A 201 (-3.7A)	1.05A	4r3aB-4r38A: 16.8	4r3aB-4r38A: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ru0	PUTATIVE BRANCHED-CHAIN AMINO ACID ABC TRANSPORTER, PERIPLASMIC BRANCHED-CHAIN AMINO ACID-BINDING PROTEIN (Pseudomonas protegens)	PF13458 (Peripla_BP_6)	5	ALA A 334 ILE A 129 ILE A 364 LEU A 381 GLN A 379	None	1.00A	4r3aB-4ru0A: undetectable	4r3aB-4ru0A: 23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ufc	GH95 (Bacteroides ovatus)	PF14498 (Glyco_hyd_65N_2)	5	LEU A 684 ALA A 382 ASN A 714 ASN A 734 GLY A 708	None	0.89A	4r3aB-4ufcA: undetectable	4r3aB-4ufcA: 17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wn9	NITROGENASE MOLYBDENUM-IRON PROTEIN ALPHA CHAIN (Clostridium pasteurianum)	PF00148 (Oxidored_nitro)	5	ARG A 297 ALA A 317 ILE A 320 ILE A 232 GLY A 492	None	1.01A	4r3aB-4wn9A: undetectable	4r3aB-4wn9A: 19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wuj	GLYCOSIDE HYDROLASE FAMILY 15, CELLULOSE SIGNALING ASSOCIATED PROTEIN ENVOY (Trichoderma reesei)	PF13426 (PAS_9)	7	ALA A 200 ILE A 161 ILE A 171 ASN A 173 ASN A 183 GLY A 202 GLN A 204	FMN  A5201 (-2.8A) FMN  A5201 (-3.8A) FMN  A5201 ( 4.4A) FMN  A5201 (-2.4A) FMN  A5201 (-4.1A) FMN  A5201 (-3.0A) FMN  A5201 (-3.7A)	1.42A	4r3aB-4wujA: 12.2	4r3aB-4wujA: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wuj	GLYCOSIDE HYDROLASE FAMILY 15, CELLULOSE SIGNALING ASSOCIATED PROTEIN ENVOY (Trichoderma reesei)	PF13426 (PAS_9)	8	CYH A 135 ARG A 136 ILE A 161 ILE A 171 ASN A 173 ASN A 183 GLY A 202 GLN A 204	FMN  A5201 (-3.5A) FMN  A5201 (-3.7A) FMN  A5201 (-3.8A) FMN  A5201 ( 4.4A) FMN  A5201 (-2.4A) FMN  A5201 (-4.1A) FMN  A5201 (-3.0A) FMN  A5201 (-3.7A)	0.70A	4r3aB-4wujA: 12.2	4r3aB-4wujA: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wz9	AGAP004809-PA (Anopheles gambiae)	PF01433 (Peptidase_M1) PF11838 (ERAP1_C)	5	ALA A 264 ALA A 323 ILE A 322 GLY A 336 GLN A 371	None	0.89A	4r3aB-4wz9A: undetectable	4r3aB-4wz9A: 16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4wz9	AGAP004809-PA (Anopheles gambiae)	PF01433 (Peptidase_M1) PF11838 (ERAP1_C)	5	ALA A 323 ILE A 322 ILE A 364 GLY A 336 GLN A 371	None	1.01A	4r3aB-4wz9A: undetectable	4r3aB-4wz9A: 16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5a8b	PTAUREO1A LOV2 DOMAIN (Phaeodactylum tricornutum)	PF13426 (PAS_9)	6	ARG A 288 ILE A 307 ASN A 319 ASN A 329 GLY A 348 GLN A 350	FMN  A 500 (-4.1A) FMN  A 500 (-4.8A) FMN  A 500 (-3.0A) FMN  A 500 (-4.2A) FMN  A 500 (-3.8A) FMN  A 500 (-3.9A)	0.53A	4r3aB-5a8bA: 14.0	4r3aB-5a8bA: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5a8b	PTAUREO1A LOV2 DOMAIN (Phaeodactylum tricornutum)	PF13426 (PAS_9)	6	CYH A 287 ARG A 288 ILE A 307 ASN A 319 GLY A 348 GLN A 350	FMN  A 500 (-3.6A) FMN  A 500 (-4.1A) FMN  A 500 (-4.8A) FMN  A 500 (-3.0A) FMN  A 500 (-3.8A) FMN  A 500 (-3.9A)	0.81A	4r3aB-5a8bA: 14.0	4r3aB-5a8bA: 18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dju	NPH1-2 (Avena sativa)	PF13426 (PAS_9)	6	ARG A 451 ILE A 470 ASN A 482 ASN A 492 GLY A 511 GLN A 513	FMN  A 601 ( 3.8A) CL  A 603 (-4.4A) FMN  A 601 (-3.1A) FMN  A 601 (-3.9A) FMN  A 601 (-3.8A) FMN  A 601 (-3.8A)	0.38A	4r3aB-5djuA: 17.9	4r3aB-5djuA: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5dkk	LOV DOMAIN (Phaeodactylum tricornutum)	PF13426 (PAS_9)	7	CYH A 287 ARG A 288 ILE A 307 ASN A 319 ASN A 329 GLY A 348 GLN A 350	FMN  A 401 (-3.4A) FMN  A 401 (-4.1A) FMN  A 401 (-4.6A) FMN  A 401 (-3.0A) FMN  A 401 (-4.1A) FMN  A 401 (-3.7A) FMN  A 401 (-3.8A)	0.83A	4r3aB-5dkkA: 14.4	4r3aB-5dkkA: 18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fd4	COMR (Streptococcus suis)	PF13560 (HTH_31)	5	ALA A  22 ARG A  14 ALA A  60 ILE A  44 LEU A  41	None	1.02A	4r3aB-5fd4A: undetectable	4r3aB-5fd4A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5fmg	PROTEASOME SUBUNIT BETA TYPE PROTEASOME, PUTATIVE (Plasmodium falciparum)	PF00227 (Proteasome)	5	ALA H 166 ALA N  35 LEU N  58 GLY H 171 GLN N  62	None	0.83A	4r3aB-5fmgH: undetectable	4r3aB-5fmgH: 20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hzh	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1,NPH1-1,RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 (Avena sativa; Homo sapiens)	PF00071 (Ras) PF13426 (PAS_9)	6	ARG A  98 ILE A 117 ASN A 129 ASN A 139 GLY A 158 GLN A 160	FMN  A 402 (-3.3A) FMN  A 402 (-4.8A) FMN  A 402 (-2.9A) FMN  A 402 (-4.2A) FMN  A 402 (-3.7A) FMN  A 402 (-3.6A)	0.46A	4r3aB-5hzhA: 18.2	4r3aB-5hzhA: 26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hzk	INTERSECTIN-1,NPH1-1 ,INTERSECTIN-1 (Avena sativa; Homo sapiens)	PF00621 (RhoGEF) PF13426 (PAS_9) PF16652 (PH_13)	6	ARG B1356 ILE B1375 ASN B1387 ASN B1397 GLY B1416 GLN B1418	FMN  B1801 (-3.9A) FMN  B1801 (-4.9A) FMN  B1801 (-3.0A) FMN  B1801 (-4.2A) FMN  B1801 (-3.7A) FMN  B1801 (-3.7A)	0.50A	4r3aB-5hzkB: 18.1	4r3aB-5hzkB: 26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hzk	INTERSECTIN-1,NPH1-1 ,INTERSECTIN-1 (Avena sativa; Homo sapiens)	PF00621 (RhoGEF) PF13426 (PAS_9) PF16652 (PH_13)	5	CYH B1355 ARG B1356 ILE B1375 GLY B1416 GLN B1418	FMN  B1801 (-3.5A) FMN  B1801 (-3.9A) FMN  B1801 (-4.9A) FMN  B1801 (-3.7A) FMN  B1801 (-3.7A)	0.95A	4r3aB-5hzkB: 18.1	4r3aB-5hzkB: 26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5icq	METHYLOCYSTIS PARVUS OBBP MBNE (Methylocystis parvus)	PF00496 (SBP_bac_5)	5	LEU A  70 ALA A 579 ILE A 584 LEU A 602 GLY A 599	None	0.98A	4r3aB-5icqA: undetectable	4r3aB-5icqA: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5it5	ATP BINDING MOTIF-CONTAINING PROTEIN PILF (Thermus thermophilus)	no annotation	5	ARG F 754 ALA F 851 ILE F 765 LEU F 769 GLY F 771	None	0.96A	4r3aB-5it5F: 2.8	4r3aB-5it5F: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5j3w	SENSORY BOX PROTEIN (Pseudomonas putida)	PF13426 (PAS_9)	9	ALA A  21 LEU A  30 CYH A  53 ARG A  54 ASN A  85 ASN A  95 LEU A  97 GLY A 114 GLN A 116	FMN  A 500 (-3.6A) None FMN  A 500 (-3.6A) FMN  A 500 (-3.5A) FMN  A 500 (-3.0A) FMN  A 500 (-4.3A) FMN  A 500 (-4.2A) FMN  A 500 (-3.8A) FMN  A 500 (-4.5A)	0.63A	4r3aB-5j3wA: 13.4	4r3aB-5j3wA: 20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5j6s	ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (Homo sapiens)	PF01433 (Peptidase_M1) PF11838 (ERAP1_C)	5	ALA A 265 ALA A 327 ILE A 326 GLY A 340 GLN A 375	None	0.93A	4r3aB-5j6sA: undetectable	4r3aB-5j6sA: 15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5m0y	CELLULOSOME ANCHORING PROTEIN COHESIN REGION IG DOMAIN PROTEIN GROUP 2 DOMAIN PROTEIN (Ruminiclostridium thermocellum)	PF00963 (Cohesin) no annotation	5	ALA A 110 LEU A 109 ALA B 151 ILE B 150 GLY A  91	None	1.01A	4r3aB-5m0yA: undetectable	4r3aB-5m0yA: 19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5mfb	YIII(DQ)4CQI (synthetic construct)	PF00514 (Arm)	5	ALA A 180 ALA A 204 ILE A 203 ASN A 169 ASN A 210	None	0.98A	4r3aB-5mfbA: undetectable	4r3aB-5mfbA: 23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ng6	CRISPR-ASSOCIATED ENDONUCLEASE CPF1 (Francisella tularensis)	no annotation	5	ALA A 459 LEU A 460 ILE A 542 LEU A 399 GLY A 414	None	0.81A	4r3aB-5ng6A: undetectable	4r3aB-5ng6A: 13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5no7	LYTIC POLYSACCHARIDE MONOOXYGENASE (Trametes cinnabarina)	no annotation	5	ALA A 242 ILE A 241 ILE A 165 GLY A 172 GLN A 174	BMA  A 321 ( 4.4A) MAN  A 322 (-4.7A) None None None	0.99A	4r3aB-5no7A: undetectable	4r3aB-5no7A: 13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5svw	ADAGIO PROTEIN 1 (Arabidopsis thaliana)	no annotation	7	CYH B  54 ARG B  55 ILE B  83 ASN B  95 ASN B 105 LEU B 107 GLN B 126	FMN  B5201 (-3.3A) FMN  B5201 (-3.8A) FMN  B5201 (-4.2A) FMN  B5201 (-2.4A) FMN  B5201 (-3.8A) FMN  B5201 ( 4.5A) FMN  B5201 (-3.8A)	0.95A	4r3aB-5svwB: 13.9	4r3aB-5svwB: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5svw	ADAGIO PROTEIN 1 (Arabidopsis thaliana)	no annotation	7	CYH B  54 ARG B  55 ILE B  83 ASN B  95 ASN B 105 LEU B 107 GLY B 124	FMN  B5201 (-3.3A) FMN  B5201 (-3.8A) FMN  B5201 (-4.2A) FMN  B5201 (-2.4A) FMN  B5201 (-3.8A) FMN  B5201 ( 4.5A) FMN  B5201 (-3.0A)	0.63A	4r3aB-5svwB: 13.9	4r3aB-5svwB: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5xoe	ATP-DEPENDENT 6-PHOSPHOFRUCTOKINAS E (Staphylococcus aureus)	no annotation	5	LEU A 276 ALA A   5 ILE A   4 ILE A 100 GLY A 271	None	1.01A	4r3aB-5xoeA: undetectable	4r3aB-5xoeA: 13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5xxo	PERIPLASMIC BETA-GLUCOSIDASE (Bacteroides thetaiotaomicron)	no annotation	5	LEU A 410 ALA A 419 ILE A 418 LEU A 447 GLY A 587	None	0.83A	4r3aB-5xxoA: undetectable	4r3aB-5xxoA: 18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6bv2	AMINOPEPTIDASE N (Sus scrofa)	no annotation	5	ALA A 276 ALA A 340 ILE A 339 GLY A 353 GLN A 388	None	0.90A	4r3aB-6bv2A: undetectable	4r3aB-6bv2A: 14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6bv2	AMINOPEPTIDASE N (Sus scrofa)	no annotation	5	ALA A 340 ILE A 339 ILE A 381 GLY A 353 GLN A 388	None	0.99A	4r3aB-6bv2A: undetectable	4r3aB-6bv2A: 14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6c6l	V-TYPE PROTON ATPASE SUBUNIT A, VACUOLAR ISOFORM V-TYPE PROTON ATPASE SUBUNIT C' V-TYPE PROTON ATPASE SUBUNIT C'' (Saccharomyces cerevisiae)	no annotation	5	ALA D  77 LEU D  74 ALA C 206 ILE A 613 LEU A 617	None	0.96A	4r3aB-6c6lD: undetectable	4r3aB-6c6lD: 11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6gbv	PUTATIVE BLUE-LIGHT PHOTORECEPTOR (Dinoroseobacter shibae)	no annotation	8	CYH A  72 ARG A  73 ILE A 102 ASN A 104 ASN A 114 LEU A 116 GLY A 133 GLN A 135	FMN  A 500 (-3.7A) FMN  A 500 (-4.5A) FMN  A 500 ( 4.3A) FMN  A 500 (-3.0A) FMN  A 500 (-4.0A) FMN  A 500 (-4.1A) FMN  A 500 (-3.9A) FMN  A 500 (-3.8A)	0.65A	4r3aB-6gbvA: 14.8	4r3aB-6gbvA: undetectable