SIMILAR PATTERNS OF AMINO ACIDS FOR 4R3A_A_RBFA402_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 GLU A 450
LEU A 102
LEU A  42
GLY A 409
 None
 0.79A 4r3aA-1a6dA:
0.7		 4r3aA-1a6dA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2h PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00496
(SBP_bac_5) 		4 ASN A 487
LEU A 270
VAL A  34
GLY A  54
 None
 0.91A 4r3aA-1b2hA:
1.0		 4r3aA-1b2hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9k PROTEIN
(ALPHA-ADAPTIN
APPENDAGE DOMAIN)

(Mus musculus) 		PF02296
(Alpha_adaptin_C)
PF02883
(Alpha_adaptinC2) 		4 THR A 810
LEU A 721
VAL A 777
GLY A 809
 None
 0.88A 4r3aA-1b9kA:
1.6		 4r3aA-1b9kA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 THR A 232
GLU A 304
ASN A 332
LEU A 286
 SO4  A 502 (-3.6A)
None
None
None
 0.87A 4r3aA-1bdgA:
0.3		 4r3aA-1bdgA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 GLU S 792
LEU S 919
LEU S 872
GLY S 931
 None
 0.83A 4r3aA-1bkdS:
undetectable		 4r3aA-1bkdS:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)

(Thermobifida
fusca) 		PF00150
(Cellulase) 		4 THR A  48
GLU A  84
ASN A 124
GLY A  23
 None
 0.85A 4r3aA-1bqcA:
undetectable		 4r3aA-1bqcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 THR A 116
VAL A 216
LEU A 190
GLY A 114
 None
 0.91A 4r3aA-1bwdA:
undetectable		 4r3aA-1bwdA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 GLU A 207
ASN A 219
LEU A 188
VAL A 175
GLY A 215
 None
 1.19A 4r3aA-1c3rA:
undetectable		 4r3aA-1c3rA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		4 GLU A 207
ASN A 219
VAL A 175
GLY A 213
 None
 0.77A 4r3aA-1c3rA:
undetectable		 4r3aA-1c3rA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhs DEOXYHYPUSINE
SYNTHASE

(Homo sapiens) 		PF01916
(DS) 		4 THR A  52
GLU A  47
VAL A  40
GLY A  33
 None
 0.91A 4r3aA-1dhsA:
0.0		 4r3aA-1dhsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		4 GLU A  95
LEU A  13
LEU A  20
GLY A 102
 None
 0.86A 4r3aA-1drtA:
undetectable		 4r3aA-1drtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		4 GLU A 265
VAL A 257
LEU A 260
GLY A 275
 None
 0.90A 4r3aA-1e19A:
undetectable		 4r3aA-1e19A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE

(Bemisia
argentifolii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 151
VAL A 183
LEU A 186
GLY A 311
 None
 0.81A 4r3aA-1e3jA:
undetectable		 4r3aA-1e3jA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT ALPHA

(Helicobacter
pylori) 		PF00547
(Urease_gamma)
PF00699
(Urease_beta) 		4 LEU A  64
VAL A  70
LEU A  30
GLY A  17
 None
 0.83A 4r3aA-1e9yA:
undetectable		 4r3aA-1e9yA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 THR A  23
GLU A 121
LEU A 235
LEU A 124
GLY A 230
 None
 1.26A 4r3aA-1ee0A:
undetectable		 4r3aA-1ee0A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 THR A  43
LEU A 138
VAL A 210
LEU A 209
GLY A  44
 None
 1.30A 4r3aA-1exfA:
undetectable		 4r3aA-1exfA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5q GAMMA HERPESVIRUS
CYCLIN

(Murid
gammaherpesvirus
4) 		PF00134
(Cyclin_N) 		4 GLU B  89
ASN B  90
LEU B 129
GLY B 122
 None
 0.77A 4r3aA-1f5qB:
undetectable		 4r3aA-1f5qB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		4 THR A 278
GLU A 272
PHE A 274
GLY A 267
 None
 0.84A 4r3aA-1fw8A:
undetectable		 4r3aA-1fw8A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		4 ASN A  15
VAL A  24
LEU A  30
GLY A 206
 None
 0.90A 4r3aA-1g8wA:
undetectable		 4r3aA-1g8wA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ASN A 228
VAL A 215
LEU A 225
PHE A 196
GLY A 174
 None
None
None
None
NAD  A 452 (-3.2A)
 1.43A 4r3aA-1geuA:
undetectable		 4r3aA-1geuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 GLU A  12
LEU A   3
LEU A 175
GLY A  49
 None
 0.76A 4r3aA-1gjuA:
undetectable		 4r3aA-1gjuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		4 LEU A 115
VAL A 130
LEU A 133
GLY A 107
 None
 0.82A 4r3aA-1hcuA:
undetectable		 4r3aA-1hcuA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica) 		PF13561
(adh_short_C2) 		4 GLU A 141
LEU A 132
VAL A  83
GLY A 145
 None
 0.77A 4r3aA-1iy8A:
undetectable		 4r3aA-1iy8A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 VAL A 439
LEU A 442
PHE A 379
GLY A 382
 None
 0.86A 4r3aA-1j0hA:
undetectable		 4r3aA-1j0hA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		5 THR A  46
GLU A  51
LEU A  95
VAL A 122
GLY A  47
 None
 1.50A 4r3aA-1j31A:
undetectable		 4r3aA-1j31A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnu PHY3 PROTEIN

(Adiantum
capillus-veneris) 		PF13426
(PAS_9) 		5 ASN A 965
LEU A 969
VAL A 979
PHE A1025
GLY A1027
 FMN  A1033 (-3.2A)
FMN  A1033 (-4.1A)
FMN  A1033 ( 4.9A)
FMN  A1033 ( 4.6A)
FMN  A1033 (-3.7A)
 0.61A 4r3aA-1jnuA:
15.4		 4r3aA-1jnuA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		4 LEU A 195
VAL A 137
PHE A 141
GLY A 177
 None
 0.86A 4r3aA-1jztA:
undetectable		 4r3aA-1jztA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 LEU A1029
VAL A1131
LEU A1134
GLY A1110
 None
 0.74A 4r3aA-1lu4A:
undetectable		 4r3aA-1lu4A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mk3 APOPTOSIS REGULATOR
BCL-W

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 LEU A  12
VAL A 126
LEU A 129
GLY A 142
 None
 0.81A 4r3aA-1mk3A:
undetectable		 4r3aA-1mk3A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt6 SET9

(Homo sapiens) 		PF00856
(SET)
PF02493
(MORN) 		5 THR A  85
GLU A  90
ASN A 113
LEU A  82
GLY A  70
 None
 1.49A 4r3aA-1mt6A:
undetectable		 4r3aA-1mt6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9l PUTATIVE BLUE LIGHT
RECEPTOR

(Chlamydomonas
reinhardtii) 		PF13426
(PAS_9) 		5 ASN A  56
LEU A  60
VAL A  70
PHE A 116
GLY A 118
 FMN  A 500 (-2.9A)
FMN  A 500 (-4.3A)
FMN  A 500 (-4.3A)
FMN  A 500 (-4.8A)
FMN  A 500 (-3.9A)
 0.40A 4r3aA-1n9lA:
15.9		 4r3aA-1n9lA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nba N-CARBAMOYLSARCOSINE
AMIDOHYDROLASE

(Arthrobacter
sp.) 		PF00857
(Isochorismatase) 		4 GLU A  80
VAL A 227
LEU A 231
GLY A  86
 None
 0.90A 4r3aA-1nbaA:
undetectable		 4r3aA-1nbaA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnl L-3-PHOSPHOSERINE
PHOSPHATASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 THR A  24
LEU A 107
VAL A 161
GLY A 178
 None
 0.86A 4r3aA-1nnlA:
undetectable		 4r3aA-1nnlA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 THR A 298
GLU A 435
LEU A 363
GLY A 295
 HEM  A 500 ( 3.6A)
None
HEM  A 500 (-4.0A)
HEM  A 500 (-3.2A)
 0.78A 4r3aA-1nr6A:
undetectable		 4r3aA-1nr6A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxi CONSERVED
HYPOTHETICAL PROTEIN
VC0424

(Vibrio cholerae) 		PF06877
(RraB) 		5 GLU A  42
LEU A  96
VAL A 101
LEU A 104
GLY A  64
 None
 1.47A 4r3aA-1nxiA:
undetectable		 4r3aA-1nxiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 GLU A 262
LEU A 253
VAL B 261
LEU B 264
 None
 0.68A 4r3aA-1oedA:
undetectable		 4r3aA-1oedA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		4 ASN A 207
LEU A 195
LEU A 210
PHE A 290
 None
 0.86A 4r3aA-1oltA:
undetectable		 4r3aA-1oltA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 THR A 165
LEU A 131
VAL A 145
LEU A 144
GLY A 235
 None
 1.35A 4r3aA-1ot5A:
undetectable		 4r3aA-1ot5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT

(Acidaminococcus
fermentans) 		PF01039
(Carboxyl_trans) 		4 LEU A 142
VAL A 282
LEU A 285
GLY A 180
 None
 0.84A 4r3aA-1pixA:
undetectable		 4r3aA-1pixA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		5 THR A 402
LEU A 282
VAL A 388
LEU A 391
GLY A 365
 None
 1.37A 4r3aA-1rq1A:
undetectable		 4r3aA-1rq1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzf FAB E51 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR H 191
ASN H 155
VAL H 182
LEU H 138
GLY H 190
 None
 1.46A 4r3aA-1rzfH:
undetectable		 4r3aA-1rzfH:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3k HU3S193 FAB
FRAGMENT, HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR H 197
ASN H 161
VAL H 188
LEU H 144
GLY H 196
 None
 1.38A 4r3aA-1s3kH:
undetectable		 4r3aA-1s3kH:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sbd SOYBEAN AGGLUTININ

(Glycine max) 		PF00139
(Lectin_legB) 		4 ASN A  17
VAL A  26
LEU A  32
GLY A 207
 None
 0.87A 4r3aA-1sbdA:
undetectable		 4r3aA-1sbdA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t12 NONSPECIFIC
LIPID-TRANSFER
PROTEIN 1

(Nicotiana
tabacum) 		PF00234
(Tryp_alpha_amyl) 		4 LEU A  15
VAL A  31
LEU A  34
GLY A   5
 None
 0.91A 4r3aA-1t12A:
undetectable		 4r3aA-1t12A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1th5 NIFU1

(Oryza sativa) 		PF01106
(NifU) 		4 LEU A 183
VAL A 161
LEU A 165
GLY A 179
 None
 0.82A 4r3aA-1th5A:
undetectable		 4r3aA-1th5A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ASN A 190
VAL A 284
LEU A 285
PHE A 194
 None
 0.89A 4r3aA-1tveA:
undetectable		 4r3aA-1tveA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj3 IGG FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR B 495
ASN B 459
VAL B 486
LEU B 442
GLY B 494
 None
 1.16A 4r3aA-1uj3B:
undetectable		 4r3aA-1uj3B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwe ANTIBODY 14D9

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR H 191
ASN H 155
VAL H 182
LEU H 138
GLY H 190
 None
 1.46A 4r3aA-1uweH:
undetectable		 4r3aA-1uweH:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1viw ALPHA-AMYLASE-INHIBI
TOR

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		4 ASN B  15
VAL B  24
LEU B  30
GLY B 178
 None
 0.86A 4r3aA-1viwB:
undetectable		 4r3aA-1viwB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		4 THR A  81
GLU A 117
ASN A 154
GLY A  55
 None
 0.89A 4r3aA-1wkyA:
undetectable		 4r3aA-1wkyA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH) 		4 THR A  46
GLU A  56
VAL A  61
LEU A  60
 None
None
None
SO4  A 703 ( 4.3A)
 0.77A 4r3aA-1wpnA:
undetectable		 4r3aA-1wpnA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		4 THR A 179
GLU A 187
ASN A 183
GLY A 164
 None
 0.90A 4r3aA-1x9yA:
undetectable		 4r3aA-1x9yA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL

(Bos taurus) 		PF00889
(EF_TS) 		4 THR B  70
GLU B 102
LEU B  81
GLY B  71
 None
 0.90A 4r3aA-1xb2B:
undetectable		 4r3aA-1xb2B:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcf TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Escherichia
coli) 		PF00290
(Trp_syntA) 		4 LEU A 209
VAL A 197
LEU A 200
GLY A 170
 None
 0.88A 4r3aA-1xcfA:
undetectable		 4r3aA-1xcfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1

(Homo sapiens) 		PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 GLU A 792
LEU A 919
LEU A 872
GLY A 931
 None
 0.83A 4r3aA-1xdvA:
undetectable		 4r3aA-1xdvA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpo RHO TRANSCRIPTION
TERMINATION FACTOR

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		5 GLU A 248
LEU A 264
VAL A 260
LEU A 313
GLY A 302
 None
 1.49A 4r3aA-1xpoA:
undetectable		 4r3aA-1xpoA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI

(Homo sapiens) 		PF00106
(adh_short) 		4 GLU A  70
LEU A  58
LEU A  68
GLY A  44
 None
 0.88A 4r3aA-1yb1A:
undetectable		 4r3aA-1yb1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis) 		PF00696
(AA_kinase) 		4 LEU A 162
VAL A 239
LEU A 238
GLY A 232
 None
 0.89A 4r3aA-1ybdA:
undetectable		 4r3aA-1ybdA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yns E-1 ENZYME

(Homo sapiens) 		no annotation 4 GLU A  36
VAL A  27
LEU A  31
GLY A 115
 None
HPO  A1261 ( 4.8A)
None
None
 0.89A 4r3aA-1ynsA:
undetectable		 4r3aA-1ynsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2p SELENOPROTEIN M

(Mus musculus) 		PF08806
(Sep15_SelM) 		4 ASN A  69
VAL A 109
LEU A 112
GLY A  36
 None
 0.89A 4r3aA-2a2pA:
undetectable		 4r3aA-2a2pA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj3 FAB M18, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR B 191
ASN B 155
VAL B 182
LEU B 138
GLY B 190
 None
 1.45A 4r3aA-2aj3B:
undetectable		 4r3aA-2aj3B:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLU A 395
ASN A 408
LEU A 186
GLY A 368
 None
 0.58A 4r3aA-2akjA:
1.3		 4r3aA-2akjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 GLU B 137
VAL B  65
LEU B  66
PHE B  47
GLY B 143
 None
 1.46A 4r3aA-2amcB:
undetectable		 4r3aA-2amcB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2as0 HYPOTHETICAL PROTEIN
PH1915

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF10672
(Methyltrans_SAM) 		4 LEU A 388
VAL A 294
LEU A 295
PHE A 300
 None
 0.90A 4r3aA-2as0A:
undetectable		 4r3aA-2as0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 THR A 308
GLU A 312
LEU A 272
GLY A 278
 None
 0.79A 4r3aA-2b5mA:
undetectable		 4r3aA-2b5mA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 GLU A 262
LEU A 253
VAL B 261
LEU B 264
 None
 0.86A 4r3aA-2bg9A:
undetectable		 4r3aA-2bg9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 LEU A 324
LEU A 331
PHE A 239
GLY A 241
 None
 0.78A 4r3aA-2bi7A:
undetectable		 4r3aA-2bi7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00155
(Aminotran_1_2) 		4 LEU A  96
LEU A 103
PHE A 242
GLY A 244
 None
 0.90A 4r3aA-2bwpA:
undetectable		 4r3aA-2bwpA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byk CHRAC-14
CHRAC-16

(Drosophila
melanogaster) 		PF00808
(CBFD_NFYB_HMF) 		4 GLU A  41
VAL B  82
LEU B  85
PHE A  44
 None
 0.89A 4r3aA-2bykA:
undetectable		 4r3aA-2bykA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		4 ASN A 112
LEU A  15
PHE A  42
GLY A  44
 None
 0.83A 4r3aA-2c1cA:
1.7		 4r3aA-2c1cA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		4 ASN A 269
LEU A 266
VAL A 297
GLY A 194
 None
 0.91A 4r3aA-2cb0A:
1.5		 4r3aA-2cb0A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 LEU A 225
VAL A  94
LEU A  93
GLY A 291
 None
 0.89A 4r3aA-2cevA:
undetectable		 4r3aA-2cevA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 ASN A 410
VAL A 428
LEU A 419
GLY A 529
 None
 0.90A 4r3aA-2cw7A:
undetectable		 4r3aA-2cw7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 THR A 255
ASN A 261
LEU A 167
LEU A 303
GLY A 307
 None
 1.48A 4r3aA-2d2iA:
2.3		 4r3aA-2d2iA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egu CYSTEINE SYNTHASE

(Geobacillus
kaustophilus) 		PF00291
(PALP) 		5 GLU A  36
LEU A 262
VAL A  18
LEU A  33
GLY A 268
 None
 1.21A 4r3aA-2eguA:
undetectable		 4r3aA-2eguA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		5 ASN A 114
LEU A  83
LEU A  77
PHE A 136
GLY A 138
 None
 1.34A 4r3aA-2ejaA:
undetectable		 4r3aA-2ejaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 ASN A 326
LEU A  39
VAL A 254
GLY A 206
 HMG  A 500 (-3.2A)
None
None
HMG  A 500 (-3.7A)
 0.87A 4r3aA-2fa0A:
0.7		 4r3aA-2fa0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgn PHOSPHOLIPASE C

(Bacillus cereus) 		PF00882
(Zn_dep_PLPC) 		4 ASN A  19
VAL A  37
LEU A  40
GLY A 114
 None
 0.79A 4r3aA-2fgnA:
undetectable		 4r3aA-2fgnA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fki PROTEIN YJBR

(Escherichia
coli) 		PF04237
(YjbR) 		4 GLU A 109
LEU A 118
VAL A 104
LEU A 107
 None
 0.85A 4r3aA-2fkiA:
undetectable		 4r3aA-2fkiA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv0 UNSATURATED
GLUCURONYL HYDROLASE

(Bacillus sp.
GL1) 		PF07470
(Glyco_hydro_88) 		4 THR A 350
VAL A 314
LEU A 317
GLY A 336
 None
 0.75A 4r3aA-2fv0A:
undetectable		 4r3aA-2fv0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 GLU A 131
LEU A  49
LEU A  68
GLY A  32
 None
 0.90A 4r3aA-2g39A:
undetectable		 4r3aA-2g39A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g39 ACETYL-COA HYDROLASE

(Pseudomonas
aeruginosa) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 THR A 145
GLU A 288
VAL A  90
GLY A  40
 None
ACY  A 901 (-2.6A)
None
None
 0.84A 4r3aA-2g39A:
undetectable		 4r3aA-2g39A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 THR A 414
LEU A 426
LEU A 470
GLY A 443
 None
 0.86A 4r3aA-2g3nA:
undetectable		 4r3aA-2g3nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A  22
LEU A 358
LEU A 246
GLY A 243
 None
 0.88A 4r3aA-2gp6A:
undetectable		 4r3aA-2gp6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gyq YCFI, PUTATIVE
STRUCTURAL PROTEIN

(Rhodopseudomonas
palustris) 		PF05974
(DUF892) 		4 LEU A 131
VAL A 137
LEU A 140
GLY A  18
 None
 0.87A 4r3aA-2gyqA:
1.3		 4r3aA-2gyqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		4 THR A   9
LEU A 143
LEU A 129
GLY A  11
 None
 0.88A 4r3aA-2hi1A:
undetectable		 4r3aA-2hi1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 4 THR A 172
GLU A 134
PHE A 120
GLY A 122
 None
 0.81A 4r3aA-2hihA:
undetectable		 4r3aA-2hihA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hkv HYPOTHETICAL PROTEIN

(Exiguobacterium
sibiricum) 		PF05163
(DinB) 		4 LEU A 132
VAL A  45
LEU A  49
GLY A  15
 None
 0.86A 4r3aA-2hkvA:
undetectable		 4r3aA-2hkvA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hn1 MAGNESIUM AND COBALT
TRANSPORTER

(Archaeoglobus
fulgidus) 		PF01544
(CorA) 		5 THR A  29
GLU A  23
VAL A  19
LEU A  96
GLY A  71
 None
 1.43A 4r3aA-2hn1A:
undetectable		 4r3aA-2hn1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASN A 269
LEU A 276
VAL A 291
GLY A 190
 None
 0.76A 4r3aA-2i6tA:
undetectable		 4r3aA-2i6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A

(Homo sapiens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASN A 269
LEU A 276
VAL A 291
GLY A 191
 None
 0.82A 4r3aA-2i6tA:
undetectable		 4r3aA-2i6tA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihw LIPOAMIDE
ACYLTRANSFERASE
COMPONENT OF
BRANCHED-CHAIN
ALPHA-KETO ACID
DEHYDROGENASE
COMPLEX

(Bos taurus) 		PF00198
(2-oxoacid_dh) 		4 THR A 336
LEU A 293
LEU A 330
GLY A 284
 None
ACT  A 601 (-4.5A)
None
None
 0.70A 4r3aA-2ihwA:
undetectable		 4r3aA-2ihwA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermus
thermophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 GLU A 197
LEU A 244
LEU A 251
GLY A 260
 None
 0.76A 4r3aA-2ip4A:
undetectable		 4r3aA-2ip4A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iz7 MOCO CARRIER PROTEIN

(Chlamydomonas
reinhardtii) 		no annotation 4 LEU A 128
VAL A 160
LEU A 163
GLY A 145
 None
 0.87A 4r3aA-2iz7A:
undetectable		 4r3aA-2iz7A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4d CRYPTOCHROME DASH

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 THR A  90
ASN A  48
LEU A 102
PHE A  97
GLY A  95
 None
 1.37A 4r3aA-2j4dA:
undetectable		 4r3aA-2j4dA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwg BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF01740
(STAS)
PF13426
(PAS_9) 		5 ASN A  61
LEU A  65
VAL A  75
PHE A 119
GLY A 121
 FMN  A 900 (-2.0A)
FMN  A 900 ( 4.1A)
None
None
FMN  A 900 (-2.9A)
 1.06A 4r3aA-2mwgA:
12.2		 4r3aA-2mwgA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2num UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT

(Rhodobacter
sphaeroides) 		PF00355
(Rieske) 		4 GLU A 121
VAL A 124
LEU A 123
GLY A  85
 None
 0.90A 4r3aA-2numA:
undetectable		 4r3aA-2numA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 THR A 135
GLU A 193
VAL A 425
GLY A 115
 THR  A 135 ( 0.8A)
GLU  A 193 ( 0.6A)
VAL  A 425 ( 0.6A)
GLY  A 115 ( 0.0A)
 0.71A 4r3aA-2ogsA:
undetectable		 4r3aA-2ogsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		4 GLU A 211
LEU A 173
VAL A 215
GLY A 151
 None
 0.75A 4r3aA-2oi6A:
undetectable		 4r3aA-2oi6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		5 THR A1658
LEU A1649
VAL A1666
LEU A1457
GLY A1657
 None
 1.33A 4r3aA-2oo4A:
undetectable		 4r3aA-2oo4A:
20.49