SIMILAR PATTERNS OF AMINO ACIDS FOR 4R38_C_RBFC201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN


(Mus musculus)
PF06482
(Endostatin)
5 ILE A 246
VAL A 150
LEU A 151
ILE A 170
PHE A 121
None
1.34A 4r38C-1dy2A:
undetectable
4r38C-1dy2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli)
PF00224
(PK)
PF02887
(PK_C)
5 THR A  95
VAL A 163
LEU A 160
ILE A 165
PHE A  93
None
1.17A 4r38C-1e0tA:
undetectable
4r38C-1e0tA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE


(Sus scrofa)
PF00162
(PGK)
5 ILE A 252
LEU A 268
LEU A 281
ILE A 279
PHE A 241
None
1.13A 4r38C-1hdiA:
undetectable
4r38C-1hdiA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1


(Homo sapiens)
PF00704
(Glyco_hydro_18)
5 THR A 260
ASN A 374
LEU A  24
LEU A  46
ILE A  54
None
1.19A 4r38C-1hjvA:
0.0
4r38C-1hjvA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1


(Homo sapiens)
PF00704
(Glyco_hydro_18)
5 THR A 260
LEU A  24
LEU A  46
ILE A  54
PHE A 359
None
1.27A 4r38C-1hjvA:
0.0
4r38C-1hjvA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE


(Escherichia
coli)
PF00815
(Histidinol_dh)
5 ASN A 321
LEU A 240
VAL A 339
LEU A 338
ILE A 330
None
1.24A 4r38C-1kaeA:
undetectable
4r38C-1kaeA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica)
PF00069
(Pkinase)
5 THR A  94
ILE A 101
VAL A 209
LEU A 197
ILE A 364
None
1.08A 4r38C-1kobA:
0.9
4r38C-1kobA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA


(Escherichia
coli)
PF02492
(cobW)
PF07683
(CobW_C)
5 THR A  55
ILE A  89
VAL A  95
LEU A  94
ILE A  96
None
1.04A 4r38C-1nijA:
1.9
4r38C-1nijA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT


(Bacillus
subtilis)
PF11563
(Protoglobin)
5 ILE A 100
LEU A  79
VAL A  89
LEU A  92
ILE A  83
None
HEM  A 180 (-4.1A)
None
CYN  A 181 (-3.5A)
None
1.20A 4r38C-1or4A:
undetectable
4r38C-1or4A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1


(Streptomyces
coelicolor)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 THR A 400
ILE A 351
LEU A 363
VAL A  10
ILE A   7
MG  A1095 (-3.9A)
None
None
None
None
1.26A 4r38C-1tqyA:
undetectable
4r38C-1tqyA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz9 MANNONATE
DEHYDRATASE


(Enterococcus
faecalis)
PF03786
(UxuA)
5 ILE A 194
LEU A 228
VAL A 183
LEU A 186
ILE A 221
None
1.25A 4r38C-1tz9A:
undetectable
4r38C-1tz9A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1y HYPOTHETICAL PROTEIN
TT0321


(Thermus
thermophilus)
PF13561
(adh_short_C2)
5 ILE A  22
ASN A  83
VAL A 174
ILE A 172
PHE A  26
None
1.34A 4r38C-2d1yA:
undetectable
4r38C-2d1yA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG


(Mus musculus)
PF01612
(DNA_pol_A_exo1)
5 GLU A  78
LEU A 215
VAL A 132
LEU A 171
ILE A 217
None
None
None
SO4  A 501 (-3.9A)
None
1.32A 4r38C-2e6mA:
undetectable
4r38C-2e6mA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5g PUTATIVE LIPOPROTEIN

(Campylobacter
jejuni)
PF04187
(Cofac_haem_bdg)
5 THR X 221
ILE X 240
LEU X 215
LEU X  36
ILE X  60
None
1.31A 4r38C-2g5gX:
undetectable
4r38C-2g5gX:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf9 RAS-RELATED PROTEIN
RAB-3D


(Homo sapiens)
PF00071
(Ras)
5 ILE A  71
LEU A  39
VAL A 175
LEU A 179
PHE A  23
None
1.17A 4r38C-2gf9A:
undetectable
4r38C-2gf9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA


(Aquifex
aeolicus)
PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C)
5 GLU A 271
LEU A 305
VAL A 320
LEU A 324
ILE A 308
None
1.33A 4r38C-2hcbA:
undetectable
4r38C-2hcbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 THR A 751
GLU A 731
LEU A 464
ILE A 462
PHE A 728
None
1.17A 4r38C-2iujA:
undetectable
4r38C-2iujA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgq TRIOSEPHOSPHATE
ISOMERASE


(Helicobacter
pylori)
PF00121
(TIM)
5 ILE A 118
LEU A 140
LEU A 149
ILE A 185
PHE A 108
None
1.29A 4r38C-2jgqA:
undetectable
4r38C-2jgqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jwy UNCHARACTERIZED
LIPOPROTEIN YAJI


(Escherichia
coli)
PF11622
(DUF3251)
5 ILE A 104
VAL A 144
LEU A 147
ILE A  71
PHE A 149
None
1.17A 4r38C-2jwyA:
undetectable
4r38C-2jwyA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN


(Bacillus
halodurans)
PF04748
(Polysacc_deac_2)
5 THR A 164
ILE A  37
VAL A 152
LEU A 130
ILE A 148
None
1.28A 4r38C-2nlyA:
undetectable
4r38C-2nlyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ILE A1048
VAL A1053
LEU A1064
ILE A 997
PHE A1067
B3P  A 301 ( 3.7A)
None
None
None
None
1.31A 4r38C-2ooqA:
undetectable
4r38C-2ooqA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfm ADENYLOSUCCINATE
LYASE


(Bacillus
anthracis)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
5 ILE A 114
GLU A   9
LEU A 282
LEU A 326
ILE A 235
None
1.25A 4r38C-2pfmA:
undetectable
4r38C-2pfmA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB


(Nitrosomonas
europaea)
PF01272
(GreA_GreB)
PF14760
(Rnk_N)
5 ILE A   7
GLU A  38
VAL A  95
LEU A  99
ILE A  89
None
1.31A 4r38C-2pn0A:
undetectable
4r38C-2pn0A:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pr5 BLUE-LIGHT
PHOTORECEPTOR


(Bacillus
subtilis)
PF13426
(PAS_9)
5 ASN A  61
LEU A  65
VAL A  75
ILE A  92
PHE A 119
FMN  A 500 (-3.2A)
FMN  A 500 (-4.4A)
FMN  A 500 (-4.6A)
FMN  A 500 ( 4.6A)
FMN  A 500 ( 4.8A)
0.72A 4r38C-2pr5A:
17.9
4r38C-2pr5A:
40.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE


(Homo sapiens)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 THR A 103
LEU A  56
VAL A  63
LEU A  88
ILE A  78
None
1.20A 4r38C-2q50A:
undetectable
4r38C-2q50A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM


(Mus musculus)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
5 ASN A 607
LEU A1000
VAL A1012
LEU A 541
ILE A1015
None
1.28A 4r38C-2y3aA:
1.4
4r38C-2y3aA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE


(Pseudomonas sp.
ATCC 19121)
PF00155
(Aminotran_1_2)
5 GLU A 172
LEU A 168
VAL A 371
LEU A 370
ILE A 367
None
1.20A 4r38C-2zy2A:
undetectable
4r38C-2zy2A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahx BETA-GLUCOSIDASE A

(Clostridium
cellulovorans)
PF00232
(Glyco_hydro_1)
5 ILE A  93
LEU A 104
LEU A 150
ILE A 117
PHE A  86
None
1.32A 4r38C-3ahxA:
undetectable
4r38C-3ahxA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM


(Homo sapiens)
PF00343
(Phosphorylase)
5 ILE A 657
ASN A 541
LEU A 534
LEU A 492
ILE A 503
None
1.24A 4r38C-3cemA:
undetectable
4r38C-3cemA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1


(Saccharomyces
cerevisiae)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
5 THR A 540
GLU A 448
LEU A 458
VAL A 502
ILE A 513
None
1.28A 4r38C-3cmmA:
undetectable
4r38C-3cmmA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE


(Thiobacillus
denitrificans)
PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
5 ILE A 296
ASN A 255
LEU A  48
LEU A 248
PHE A  79
None
1.24A 4r38C-3cr8A:
undetectable
4r38C-3cr8A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eet PUTATIVE GNTR-FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
avermitilis)
PF00392
(GntR)
PF07702
(UTRA)
5 GLU A  58
LEU A  49
VAL A  12
LEU A  16
ILE A  37
None
0.97A 4r38C-3eetA:
undetectable
4r38C-3eetA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaf 7-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE


(Brucella
abortus)
PF13561
(adh_short_C2)
5 ILE A  27
ASN A  94
VAL A 184
ILE A 182
PHE A  31
None
1.28A 4r38C-3gafA:
undetectable
4r38C-3gafA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN


(Legionella
pneumophila)
no annotation 5 ILE A 165
VAL A 113
LEU A 114
ILE A 111
PHE A 133
None
1.29A 4r38C-3gozA:
undetectable
4r38C-3gozA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana)
PF00248
(Aldo_ket_red)
5 THR A  99
ILE A  51
LEU A 146
VAL A 157
LEU A 112
None
1.31A 4r38C-3h7uA:
undetectable
4r38C-3h7uA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm7 PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE /
2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE


(Yersinia
enterocolitica)
PF07071
(KDGP_aldolase)
5 THR A 190
LEU A  17
VAL A 234
LEU A 237
ILE A 221
None
1.00A 4r38C-3lm7A:
undetectable
4r38C-3lm7A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0z PUTATIVE ALDOLASE

(Klebsiella
pneumoniae)
PF07071
(KDGP_aldolase)
6 THR A 190
ILE A 213
LEU A  17
VAL A 234
LEU A 237
ILE A 221
None
1.07A 4r38C-3m0zA:
undetectable
4r38C-3m0zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE


(Bacillus
anthracis)
PF07071
(KDGP_aldolase)
5 THR A 192
LEU A  18
VAL A 236
LEU A 239
ILE A 223
None
0.91A 4r38C-3muxA:
undetectable
4r38C-3muxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE


(Gluconobacter
oxydans)
PF00248
(Aldo_ket_red)
5 ILE A  42
LEU A 126
VAL A 121
LEU A 119
ILE A 124
None
1.22A 4r38C-3n2tA:
undetectable
4r38C-3n2tA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3u ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE IBPA


(Histophilus
somni)
PF02661
(Fic)
5 LEU A3502
VAL A3584
LEU A3775
ILE A3580
PHE A3743
None
1.23A 4r38C-3n3uA:
undetectable
4r38C-3n3uA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE


(Escherichia
coli)
PF02784
(Orn_Arg_deC_N)
5 ILE A 358
VAL A 158
LEU A 147
ILE A 135
PHE A 121
None
1.22A 4r38C-3nzqA:
undetectable
4r38C-3nzqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE


(Aliivibrio
fischeri)
PF07071
(KDGP_aldolase)
6 THR A 190
ILE A 213
LEU A  17
VAL A 234
LEU A 237
ILE A 221
None
1.07A 4r38C-3nzrA:
undetectable
4r38C-3nzrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF


(Bacillus
subtilis)
PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6)
5 THR A 198
LEU A  42
VAL A  31
LEU A  34
ILE A  11
None
1.08A 4r38C-3pdwA:
undetectable
4r38C-3pdwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rab PROTEIN (RAB3A)

(Rattus
norvegicus)
PF00071
(Ras)
5 ILE A  71
LEU A  39
LEU A 179
ILE A  99
PHE A  23
ILE  A  71 ( 0.7A)
LEU  A  39 ( 0.6A)
LEU  A 179 ( 0.6A)
ILE  A  99 ( 0.7A)
PHE  A  23 ( 1.3A)
0.94A 4r38C-3rabA:
undetectable
4r38C-3rabA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A 371
LEU A 360
VAL A 121
LEU A 366
ILE A   2
None
1.31A 4r38C-3rzaA:
undetectable
4r38C-3rzaA:
15.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t50 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE


(Brucella
melitensis)
PF13426
(PAS_9)
5 ASN A  68
LEU A  72
VAL A  82
ILE A  99
PHE A 128
FMN  A 200 (-3.1A)
FMN  A 200 (-4.3A)
FMN  A 200 (-4.3A)
FMN  A 200 ( 4.4A)
FMN  A 200 (-4.5A)
0.78A 4r38C-3t50A:
19.9
4r38C-3t50A:
34.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE


(Leishmania
donovani)
PF00291
(PALP)
5 THR A 259
ILE A 228
VAL A 208
LEU A 249
ILE A 285
None
1.22A 4r38C-3tbhA:
undetectable
4r38C-3tbhA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udb SERINE/THREONINE-PRO
TEIN KINASE SRK2E


(Arabidopsis
thaliana)
PF00069
(Pkinase)
5 ILE A 246
GLU A 114
LEU A 124
LEU A 253
ILE A 271
None
1.09A 4r38C-3udbA:
undetectable
4r38C-3udbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E


(Arabidopsis
thaliana)
PF00069
(Pkinase)
5 ILE A 246
GLU A 114
LEU A 124
LEU A 253
ILE A 271
None
1.10A 4r38C-3ujgA:
undetectable
4r38C-3ujgA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum)
PF03136
(Pup_ligase)
5 THR A 206
GLU A 131
VAL A 244
LEU A 245
ILE A 248
None
1.17A 4r38C-4b0tA:
undetectable
4r38C-4b0tA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae)
PF01274
(Malate_synthase)
5 THR A 110
ILE A 516
LEU A 336
VAL A 401
PHE A 510
None
1.14A 4r38C-4ex4A:
undetectable
4r38C-4ex4A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga7 LEUKOCYTE ELASTASE
INHIBITOR


(Homo sapiens)
PF00079
(Serpin)
5 THR A 251
ILE A 370
VAL A 216
LEU A 231
ILE A 209
None
1.32A 4r38C-4ga7A:
undetectable
4r38C-4ga7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcz BLUE-LIGHT
PHOTORECEPTOR,
SENSOR PROTEIN FIXL


(Bacillus
subtilis;
Bradyrhizobium
diazoefficiens)
PF00512
(HisKA)
PF02518
(HATPase_c)
PF13426
(PAS_9)
5 ASN A  61
LEU A  65
VAL A  75
ILE A  92
PHE A 119
FMN  A 401 (-3.1A)
FMN  A 401 (-4.5A)
FMN  A 401 ( 4.6A)
FMN  A 401 ( 4.6A)
FMN  A 401 (-4.7A)
0.81A 4r38C-4gczA:
18.3
4r38C-4gczA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imr 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Agrobacterium
fabrum)
PF13561
(adh_short_C2)
5 ILE A  27
LEU A 126
VAL A  88
LEU A  15
ILE A  79
None
1.26A 4r38C-4imrA:
undetectable
4r38C-4imrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Escherichia
coli)
PF03331
(LpxC)
5 ILE A 244
ASN A 253
LEU A  87
ILE A 120
PHE A 182
None
FMT  A 420 (-3.7A)
None
None
None
1.26A 4r38C-4isaA:
undetectable
4r38C-4isaA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium)
PF00144
(Beta-lactamase)
5 THR A 159
ILE A 224
VAL A 209
LEU A 208
PHE A 132
None
1.29A 4r38C-4iviA:
undetectable
4r38C-4iviA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdy PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS


(Mycobacterium
tuberculosis)
PF01680
(SOR_SNZ)
5 ILE A 121
LEU A  50
LEU A  98
ILE A  72
PHE A 130
None
1.25A 4r38C-4jdyA:
undetectable
4r38C-4jdyA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN


(Pseudovibrio
sp. JE062)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A  11
VAL A 363
LEU A  14
ILE A  37
PHE A  60
None
1.16A 4r38C-4jhmA:
undetectable
4r38C-4jhmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkl BETA-GLUCURONIDASE

(Streptococcus
agalactiae)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
5 ILE A 442
GLU A 408
ASN A 407
LEU A 136
PHE A 357
None
1.28A 4r38C-4jklA:
undetectable
4r38C-4jklA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3z D-ERYTHRULOSE
4-PHOSPHATE
DEHYDROGENASE


(Brucella
melitensis)
no annotation 5 THR A  38
ILE A 225
GLU A 269
VAL A 294
ILE A 290
None
1.34A 4r38C-4k3zA:
undetectable
4r38C-4k3zA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE


(Thermotoga
maritima)
PF01148
(CTP_transf_1)
5 ILE A  49
LEU A  58
VAL A 134
LEU A 138
ILE A 268
None
1.35A 4r38C-4q2eA:
undetectable
4r38C-4q2eA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7l UNCHARACTERIZED ABC
TRANSPORTER
ATP-BINDING PROTEIN
TM_0288


(Thermotoga
maritima)
PF00005
(ABC_tran)
5 ILE A 422
LEU A 513
VAL A 398
LEU A 401
ILE A 544
None
1.21A 4r38C-4q7lA:
undetectable
4r38C-4q7lA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE


(Thermococcus
kodakarensis)
PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 THR A 667
GLU B 972
LEU B 928
VAL B 991
ILE B 992
None
1.28A 4r38C-4qiwA:
undetectable
4r38C-4qiwA:
10.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2


(Erythrobacter
litoralis)
PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2)
9 THR A  21
ILE A  25
GLU A  30
ASN A  54
LEU A  58
VAL A  68
LEU A  71
ILE A  85
PHE A 114
RBF  A 402 (-3.4A)
None
None
RBF  A 402 (-2.9A)
RBF  A 402 (-4.2A)
RBF  A 402 (-3.5A)
RBF  A 402 (-3.6A)
RBF  A 402 (-4.0A)
RBF  A 402 ( 4.3A)
0.48A 4r38C-4r3aA:
16.9
4r38C-4r3aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9p RE28239P

(Drosophila
melanogaster)
PF03166
(MH2)
5 ILE A 153
LEU A 232
VAL A 224
LEU A 202
ILE A  42
None
1.18A 4r38C-4r9pA:
undetectable
4r38C-4r9pA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY


(Trichoderma
reesei)
PF13426
(PAS_9)
6 THR A 101
ILE A 105
ASN A 134
LEU A 138
VAL A 154
ILE A 171
FMN  A5201 (-3.4A)
None
FMN  A5201 (-2.5A)
FMN  A5201 (-3.7A)
FMN  A5201 (-3.6A)
FMN  A5201 ( 4.4A)
0.78A 4r38C-4wujA:
15.4
4r38C-4wujA:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS


(Geobacillus
kaustophilus)
PF01680
(SOR_SNZ)
5 ILE A 116
LEU A  45
LEU A  93
ILE A  67
PHE A 125
None
L5P  A  81 ( 4.8A)
None
None
None
1.32A 4r38C-4wxzA:
undetectable
4r38C-4wxzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx8 DSBA-LIKE PROTEIN

(Proteus
mirabilis)
PF13462
(Thioredoxin_4)
5 ILE A 201
LEU A  93
VAL A 106
LEU A  76
ILE A  97
None
1.26A 4r38C-4yx8A:
undetectable
4r38C-4yx8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9x GLUCONATE
5-DEHYDROGENASE


(Streptococcus
pyogenes)
PF13561
(adh_short_C2)
5 ILE A 123
ASN A  92
LEU A 129
ILE A 181
PHE A 122
None
1.34A 4r38C-4z9xA:
undetectable
4r38C-4z9xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT


(Corynebacterium
glutamicum)
PF01497
(Peripla_BP_2)
5 ILE A 316
LEU A 278
LEU A 289
ILE A 275
PHE A 294
None
1.28A 4r38C-5az3A:
undetectable
4r38C-5az3A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buo AMYLOID BETA A4
PROTEIN


(Homo sapiens)
PF12925
(APP_E2)
5 ILE A 451
LEU A 390
VAL A 461
ILE A 462
PHE A 437
SCN  A 714 ( 3.9A)
None
GOL  A 709 ( 4.9A)
None
None
1.23A 4r38C-5buoA:
undetectable
4r38C-5buoA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3u L-SERINE
AMMONIA-LYASE


(Rhizomucor
miehei)
PF00291
(PALP)
5 ILE A 317
GLU A 279
VAL A  82
LEU A  83
ILE A 112
None
PLP  A 401 ( 4.0A)
None
None
None
1.34A 4r38C-5c3uA:
undetectable
4r38C-5c3uA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzv PROTEIN PCDHA7

(Mus musculus)
PF00028
(Cadherin)
PF08266
(Cadherin_2)
5 GLU A 147
ASN A 146
LEU A 165
LEU A 171
ILE A 113
None
1.19A 4r38C-5dzvA:
undetectable
4r38C-5dzvA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2


(Aeropyrum
pernix)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4)
5 ILE A  74
LEU A 231
VAL A  79
LEU A  78
ILE A  80
None
1.27A 4r38C-5fg3A:
undetectable
4r38C-5fg3A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens)
PF13855
(LRR_8)
5 ILE A 403
GLU A 427
LEU A 486
LEU A 474
ILE A 422
None
1.31A 4r38C-5hdhA:
undetectable
4r38C-5hdhA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE


(Francisella
tularensis)
PF01761
(DHQ_synthase)
5 THR A 143
ILE A 107
VAL A  98
LEU A  99
ILE A 122
None
1.31A 4r38C-5hvnA:
undetectable
4r38C-5hvnA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN


(Chaetomium
thermophilum)
PF03178
(CPSF_A)
PF10433
(MMS1_N)
5 THR A  19
ILE A1118
LEU A 458
VAL A1114
ILE A  15
None
1.34A 4r38C-5hy7A:
undetectable
4r38C-5hy7A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4c TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB


(Escherichia
coli)
PF00072
(Response_reg)
5 GLU A 104
LEU A  70
VAL A  98
LEU A 101
ILE A  68
None
1.19A 4r38C-5i4cA:
undetectable
4r38C-5i4cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id4 DSBA-LIKE PROTEIN

(Proteus
mirabilis)
PF13462
(Thioredoxin_4)
5 ILE A 201
LEU A  93
VAL A 106
LEU A  76
ILE A  97
None
1.07A 4r38C-5id4A:
undetectable
4r38C-5id4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jif HEMAGGLUTININ-ESTERA
SE


(Murine
coronavirus)
PF02710
(Hema_HEFG)
PF03996
(Hema_esterase)
5 THR A 277
ILE A 152
LEU A 260
ILE A 258
PHE A 200
NA  A 801 ( 4.1A)
None
None
None
None
1.27A 4r38C-5jifA:
undetectable
4r38C-5jifA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mji BRAMP DOMAIN PROTEIN

(Streptomyces
davaonensis)
PF03358
(FMN_red)
5 THR A 196
LEU A 130
VAL A 145
LEU A 149
ILE A  87
None
1.26A 4r38C-5mjiA:
undetectable
4r38C-5mjiA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkz PEROXIN 22

(Ogataea angusta)
no annotation 5 ILE D 123
LEU D  81
VAL D 115
LEU D 119
ILE D 104
None
1.28A 4r38C-5nkzD:
undetectable
4r38C-5nkzD:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
5 THR A 388
ILE A 393
LEU A 361
ILE A 245
PHE A   4
None
1.28A 4r38C-5u4hA:
undetectable
4r38C-5u4hA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9p GLUCONATE
5-DEHYDROGENASE


(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
5 ILE A 144
ASN A  96
LEU A 198
VAL A 224
LEU A 227
None
NAP  A 301 (-3.3A)
NAP  A 301 ( 3.5A)
None
None
1.11A 4r38C-5u9pA:
undetectable
4r38C-5u9pA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxv PEROXISOMAL MEMBRANE
PROTEIN PEX15


(Saccharomyces
cerevisiae)
no annotation 5 ILE A 135
VAL A 184
LEU A 187
ILE A 237
PHE A 170
None
1.33A 4r38C-5vxvA:
undetectable
4r38C-5vxvA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wax -

(-)
no annotation 5 ILE A 238
GLU A 106
LEU A 116
LEU A 245
ILE A 263
None
1.19A 4r38C-5waxA:
undetectable
4r38C-5waxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxu 11S GLOBULIN

(Wrightia
tinctoria)
no annotation 5 GLU A  66
LEU A  75
VAL A 182
LEU A 181
ILE A 183
None
1.33A 4r38C-5wxuA:
undetectable
4r38C-5wxuA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE


(Vibrio sp. EJY3)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 THR A  37
GLU A 351
LEU A 112
ILE A 280
PHE A 352
None
1.30A 4r38C-5xd7A:
undetectable
4r38C-5xd7A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z03 MUREIN TETRAPEPTIDE
CARBOXYPEPTIDASE


(Escherichia
coli)
no annotation 5 ILE A  39
ASN A  35
LEU A   3
LEU A  71
ILE A  69
None
1.22A 4r38C-5z03A:
undetectable
4r38C-5z03A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL


(Homo sapiens)
no annotation 5 THR A 167
LEU A 221
VAL A 243
LEU A 240
ILE A 160
None
1.24A 4r38C-5zqzA:
undetectable
4r38C-5zqzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum)
PF01274
(Malate_synthase)
5 THR A 110
ILE A 515
LEU A 335
VAL A 400
PHE A 509
None
1.15A 4r38C-6axeA:
undetectable
4r38C-6axeA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)


(Homo sapiens)
no annotation 5 ILE A1657
LEU A1862
VAL A2038
LEU A2037
ILE A1864
None
1.10A 4r38C-6bq1A:
undetectable
4r38C-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 5 ILE A 415
GLU A 286
LEU A 296
LEU A 422
ILE A 440
None
1.02A 4r38C-6bqlA:
undetectable
4r38C-6bqlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY


(Paraburkholderia
phymatum)
no annotation 5 ILE A  78
LEU A 345
VAL A 204
LEU A 373
ILE A 202
None
1.26A 4r38C-6c0dA:
undetectable
4r38C-6c0dA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F


(Pyrococcus
furiosus)
no annotation 5 ILE F  17
LEU A  17
VAL B  63
LEU B  66
ILE B  62
None
1.34A 4r38C-6cfwF:
undetectable
4r38C-6cfwF:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi)
no annotation 5 ILE A 182
LEU A 220
VAL A 193
LEU A 160
ILE A 226
None
1.34A 4r38C-6d46A:
undetectable
4r38C-6d46A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2


(Saccharomyces
cerevisiae)
no annotation 5 ILE A2161
ASN A2341
LEU A2451
LEU A2263
ILE A2331
None
1.29A 4r38C-6emkA:
undetectable
4r38C-6emkA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo2 TRANSCRIPTIONAL
REGULATORY PROTEIN
RCSB


(Salmonella
enterica)
no annotation 5 GLU A 104
LEU A  70
VAL A  98
LEU A 101
ILE A  68
None
1.28A 4r38C-6eo2A:
undetectable
4r38C-6eo2A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbv PUTATIVE BLUE-LIGHT
PHOTORECEPTOR


(Dinoroseobacter
shibae)
no annotation 5 ASN A  71
LEU A  75
VAL A  85
ILE A 102
PHE A 131
FMN  A 500 ( 3.2A)
FMN  A 500 (-4.0A)
FMN  A 500 (-4.3A)
FMN  A 500 ( 4.3A)
FMN  A 500 (-4.8A)
0.79A 4r38C-6gbvA:
18.5
4r38C-6gbvA:
undetectable