SIMILAR PATTERNS OF AMINO ACIDS FOR 4R38_B_RBFB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)

(Escherichia
coli) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 235
ALA A 143
ILE A 104
GLY A  11
GLN A  83
 None
 1.01A 4r38B-1b3nA:
undetectable		 4r38B-1b3nA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzs SOPE

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		5 ALA B 210
GLN B 225
ALA B 117
ILE B 114
GLN B 223
 None
 1.21A 4r38B-1gzsB:
undetectable		 4r38B-1gzsB:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jnu PHY3 PROTEIN

(Adiantum
capillus-veneris) 		PF13426
(PAS_9) 		8 ASN A 965
CYH A 966
ARG A 967
GLN A 970
ASN A 998
ASN A1008
GLY A1027
GLN A1029
 FMN  A1033 (-3.2A)
FMN  A1033 (-1.8A)
FMN  A1033 (-3.6A)
FMN  A1033 (-3.1A)
FMN  A1033 (-3.2A)
FMN  A1033 (-4.1A)
FMN  A1033 (-3.7A)
FMN  A1033 (-4.2A)
 0.59A 4r38B-1jnuA:
19.6		 4r38B-1jnuA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 ALA A 358
ASN A 318
GLN A  61
ALA A 313
GLY A 354
 None
 1.13A 4r38B-1kplA:
undetectable		 4r38B-1kplA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 ALA A 358
ASN A 318
GLN A  61
ALA A 313
GLY A 355
 None
None
None
None
CL  A 503 (-3.5A)
 1.19A 4r38B-1kplA:
undetectable		 4r38B-1kplA:
14.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n9l PUTATIVE BLUE LIGHT
RECEPTOR

(Chlamydomonas
reinhardtii) 		PF13426
(PAS_9) 		11 ALA A  25
ASN A  56
CYH A  57
ARG A  58
GLN A  61
ILE A  77
ASN A  89
ASN A  99
LEU A 101
GLY A 118
GLN A 120
 FMN  A 500 ( 3.7A)
FMN  A 500 (-2.9A)
FMN  A 500 (-3.4A)
FMN  A 500 (-4.0A)
FMN  A 500 (-3.3A)
FMN  A 500 (-4.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.9A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.7A)
 0.52A 4r38B-1n9lA:
19.5		 4r38B-1n9lA:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n9l PUTATIVE BLUE LIGHT
RECEPTOR

(Chlamydomonas
reinhardtii) 		PF13426
(PAS_9) 		6 ALA A  25
ASN A  56
CYH A  57
ARG A  58
ILE A  77
ASN A  89
 FMN  A 500 ( 3.7A)
FMN  A 500 (-2.9A)
FMN  A 500 (-3.4A)
FMN  A 500 (-4.0A)
FMN  A 500 (-4.7A)
FMN  A 500 (-3.0A)
 1.11A 4r38B-1n9lA:
19.5		 4r38B-1n9lA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r71 TRANSCRIPTIONAL
REPRESSOR PROTEIN
KORB

(Escherichia
coli) 		PF08535
(KorB) 		5 ALA A 158
ILE A 161
ASN A 150
LEU A 147
GLY A 179
 None
 1.09A 4r38B-1r71A:
undetectable		 4r38B-1r71A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE

(Rattus
norvegicus) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 ALA A 266
ALA A 233
ILE A 211
LEU A 287
GLY A 281
 None
 1.13A 4r38B-1s3iA:
undetectable		 4r38B-1s3iA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09152
(DUF1937) 		5 ALA A  91
ARG A  21
ALA A  13
ASN A  50
GLY A  62
 None
 1.20A 4r38B-1t1jA:
undetectable		 4r38B-1t1jA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux4 BNI1 PROTEIN

(Saccharomyces
cerevisiae) 		PF02181
(FH2) 		5 GLN A1744
ILE A1737
ASN A1747
ASN A1611
LEU A1610
 None
 1.14A 4r38B-1ux4A:
undetectable		 4r38B-1ux4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		5 ALA A 386
ILE A 389
ASN A  76
LEU A  75
GLN A  72
 None
 1.23A 4r38B-1v5cA:
undetectable		 4r38B-1v5cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans) 		PF00154
(RecA) 		5 ALA A  88
ILE A  91
ASN A 262
LEU A  63
GLY A  66
 None
 1.15A 4r38B-1xp8A:
undetectable		 4r38B-1xp8A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus) 		PF00909
(Ammonium_transp) 		5 ASN A 325
ALA A 263
ASN A 334
LEU A 337
GLY A 146
 None
 1.21A 4r38B-2b2iA:
undetectable		 4r38B-2b2iA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkn 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Pseudomonas sp.
B-0831) 		PF13561
(adh_short_C2) 		5 ALA A 209
ALA A 116
ILE A 115
LEU A 191
GLY A 214
 None
None
None
NAI  A4000 ( 3.9A)
None
 0.96A 4r38B-2dknA:
undetectable		 4r38B-2dknA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A  37
ALA A  12
ILE A  13
ASN A 345
GLY A 216
 None
None
None
None
PLP  A 401 (-3.5A)
 1.19A 4r38B-2dy3A:
undetectable		 4r38B-2dy3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 ALA A 311
ARG A  78
ALA A  69
LEU A 272
GLY A 269
 None
 1.19A 4r38B-2e7uA:
undetectable		 4r38B-2e7uA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 ALA A  99
GLN A 165
ALA A 224
ILE A 225
GLY A 174
 None
 1.16A 4r38B-2gouA:
undetectable		 4r38B-2gouA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		5 ALA A 155
ALA A 136
ILE A 176
ASN A  96
GLY A  90
 KCX  A 154 ( 3.4A)
None
None
None
KCX  A 154 ( 3.6A)
 1.25A 4r38B-2icsA:
undetectable		 4r38B-2icsA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwg BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF01740
(STAS)
PF13426
(PAS_9) 		7 ASN A  61
CYH A  62
GLN A  66
ASN A  94
ASN A 104
LEU A 106
GLN A 123
 FMN  A 900 (-2.0A)
FMN  A 900 (-3.3A)
FMN  A 900 (-2.6A)
FMN  A 900 (-2.9A)
FMN  A 900 (-3.9A)
FMN  A 900 (-4.3A)
FMN  A 900 (-4.2A)
 0.71A 4r38B-2mwgA:
15.3		 4r38B-2mwgA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwg BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF01740
(STAS)
PF13426
(PAS_9) 		6 CYH A  62
ARG A  63
ASN A  94
ASN A 104
GLY A 121
GLN A 123
 FMN  A 900 (-3.3A)
FMN  A 900 (-4.9A)
FMN  A 900 (-2.9A)
FMN  A 900 (-3.9A)
FMN  A 900 (-2.9A)
FMN  A 900 (-4.2A)
 1.24A 4r38B-2mwgA:
15.3		 4r38B-2mwgA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwg BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF01740
(STAS)
PF13426
(PAS_9) 		7 CYH A  62
GLN A  66
ASN A  94
ASN A 104
LEU A 106
GLY A 121
GLN A 123
 FMN  A 900 (-3.3A)
FMN  A 900 (-2.6A)
FMN  A 900 (-2.9A)
FMN  A 900 (-3.9A)
FMN  A 900 (-4.3A)
FMN  A 900 (-2.9A)
FMN  A 900 (-4.2A)
 0.56A 4r38B-2mwgA:
15.3		 4r38B-2mwgA:
26.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pr5 BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF13426
(PAS_9) 		9 ASN A  61
CYH A  62
ARG A  63
GLN A  66
ASN A  94
ASN A 104
LEU A 106
GLY A 121
GLN A 123
 FMN  A 500 (-3.2A)
FMN  A 500 (-3.5A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.9A)
 0.57A 4r38B-2pr5A:
18.0		 4r38B-2pr5A:
40.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		5 ALA A 139
ALA A 185
ASN A 208
LEU A 146
GLY A 123
 None
 0.98A 4r38B-2uz0A:
undetectable		 4r38B-2uz0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		5 ALA A 158
ALA A 120
ILE A 123
LEU A 134
GLY A  52
 None
 0.96A 4r38B-2v4yA:
undetectable		 4r38B-2v4yA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		8 ASN A 449
ARG A 451
GLN A 454
ILE A 470
ASN A 482
ASN A 492
GLY A 511
GLN A 513
 FMN  A1725 (-3.0A)
FMN  A1725 (-3.8A)
FMN  A1725 (-3.1A)
FMN  A1725 (-4.7A)
FMN  A1725 (-3.0A)
FMN  A1725 (-3.8A)
FMN  A1725 (-3.7A)
FMN  A1725 (-3.8A)
 0.64A 4r38B-2wkpA:
17.5		 4r38B-2wkpA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		6 ASN A 449
CYH A 450
ARG A 451
GLN A 454
GLY A 511
GLN A 513
 FMN  A1725 (-3.0A)
FMN  A1725 (-3.4A)
FMN  A1725 (-3.8A)
FMN  A1725 (-3.1A)
FMN  A1725 (-3.7A)
FMN  A1725 (-3.8A)
 1.00A 4r38B-2wkpA:
17.5		 4r38B-2wkpA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 ALA A  54
GLN A  89
ILE A  81
LEU A  74
GLY A  49
 None
 1.23A 4r38B-2yr0A:
undetectable		 4r38B-2yr0A:
18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z6c PHOTOTROPIN-1

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		9 ASN A 233
CYH A 234
ARG A 235
GLN A 238
ASN A 266
ASN A 276
LEU A 278
GLY A 295
GLN A 297
 FMN  A 500 (-3.0A)
FMN  A 500 (-3.4A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.6A)
 0.73A 4r38B-2z6cA:
17.8		 4r38B-2z6cA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z6d PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		9 ASN A 169
CYH A 170
ARG A 171
GLN A 174
ASN A 202
ASN A 212
LEU A 214
GLY A 231
GLN A 233
 FMN  A 500 (-3.0A)
FMN  A 500 (-3.5A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.8A)
 0.51A 4r38B-2z6dA:
19.1		 4r38B-2z6dA:
35.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z6d PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		5 GLN A 174
ALA A 184
ASN A 202
ASN A 212
LEU A 214
 FMN  A 500 (-3.0A)
None
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.3A)
 1.12A 4r38B-2z6dA:
19.1		 4r38B-2z6dA:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwi CYSTEINE SYNTHASE B

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ALA A 156
ALA A  90
ILE A  59
ASN A  45
LEU A  11
 None
 1.12A 4r38B-3dwiA:
undetectable		 4r38B-3dwiA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 241
ILE A 264
ASN A 128
LEU A 124
GLY A 326
 None
 1.23A 4r38B-3fk5A:
undetectable		 4r38B-3fk5A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ALA A 360
GLN A 197
ILE A 243
LEU A 368
GLN A 335
 None
 1.24A 4r38B-3gyrA:
undetectable		 4r38B-3gyrA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwb D-ALANINE--D-ALANINE
LIGASE

(Mycobacterium
tuberculosis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ALA A  31
ILE A  34
LEU A 117
GLY A 140
GLN A 128
 None
 1.09A 4r38B-3lwbA:
undetectable		 4r38B-3lwbA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okf 3-DEHYDROQUINATE
SYNTHASE

(Vibrio cholerae) 		PF01761
(DHQ_synthase) 		5 ALA A 256
ALA A 357
ILE A 360
LEU A 336
GLY A 250
 None
 1.03A 4r38B-3okfA:
undetectable		 4r38B-3okfA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7n SENSOR HISTIDINE
KINASE

(Erythrobacter
litoralis) 		PF00196
(GerE)
PF13426
(PAS_9) 		7 ASN A  74
CYH A  75
ARG A  76
ASN A 107
ASN A 117
GLY A 136
GLN A 138
 FMN  A 500 (-3.1A)
FMN  A 500 (-3.3A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.1A)
FMN  A 500 ( 4.0A)
FMN  A 500 (-3.9A)
 0.66A 4r38B-3p7nA:
18.7		 4r38B-3p7nA:
25.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rh8 VIVID PAS PROTEIN
VVD

(Neurospora
crassa) 		PF13426
(PAS_9) 		5 ARG B 124
ASN B 151
ASN B 161
LEU B 163
GLN B 182
 FAD  B5201 (-3.4A)
FAD  B5201 (-3.0A)
FAD  B5201 (-3.7A)
FAD  B5201 (-3.8A)
FAD  B5201 (-4.1A)
 1.13A 4r38B-3rh8B:
16.4		 4r38B-3rh8B:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rh8 VIVID PAS PROTEIN
VVD

(Neurospora
crassa) 		PF13426
(PAS_9) 		10 ASN B 107
CYH B 108
ARG B 109
GLN B 112
ILE B 139
ASN B 151
ASN B 161
LEU B 163
GLY B 180
GLN B 182
 FAD  B5201 (-3.2A)
FAD  B5201 (-1.8A)
FAD  B5201 (-4.3A)
FAD  B5201 (-3.1A)
FAD  B5201 (-4.6A)
FAD  B5201 (-3.0A)
FAD  B5201 (-3.7A)
FAD  B5201 (-3.8A)
FAD  B5201 (-3.8A)
FAD  B5201 (-4.1A)
 0.68A 4r38B-3rh8B:
16.4		 4r38B-3rh8B:
31.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t50 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE

(Brucella
melitensis) 		PF13426
(PAS_9) 		8 ASN A  68
ARG A  70
GLN A  73
ILE A  89
ASN A 101
ASN A 111
LEU A 113
GLN A 132
 FMN  A 200 (-3.1A)
FMN  A 200 (-3.9A)
FMN  A 200 (-3.1A)
FMN  A 200 (-4.5A)
FMN  A 200 (-3.1A)
FMN  A 200 (-3.8A)
FMN  A 200 (-4.3A)
FMN  A 200 (-3.9A)
 0.60A 4r38B-3t50A:
20.0		 4r38B-3t50A:
34.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t50 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE

(Brucella
melitensis) 		PF13426
(PAS_9) 		6 ASN A  68
CYH A  69
ARG A  70
GLN A  73
LEU A 113
GLN A 132
 FMN  A 200 (-3.1A)
FMN  A 200 (-3.4A)
FMN  A 200 (-3.9A)
FMN  A 200 (-3.1A)
FMN  A 200 (-4.3A)
FMN  A 200 (-3.9A)
 0.93A 4r38B-3t50A:
20.0		 4r38B-3t50A:
34.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t50 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE

(Brucella
melitensis) 		PF13426
(PAS_9) 		6 GLN A  73
ALA A  84
ASN A 101
ASN A 111
LEU A 113
GLN A 132
 FMN  A 200 (-3.1A)
None
FMN  A 200 (-3.1A)
FMN  A 200 (-3.8A)
FMN  A 200 (-4.3A)
FMN  A 200 (-3.9A)
 1.38A 4r38B-3t50A:
20.0		 4r38B-3t50A:
34.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u43 COLICIN-E2

(Escherichia
coli) 		no annotation 5 ALA B  32
ALA B  39
ILE B  34
LEU B  67
GLN B  70
 None
 1.17A 4r38B-3u43B:
undetectable		 4r38B-3u43B:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ue6 AUREOCHROME1

(Vaucheria
frigida) 		PF13426
(PAS_9) 		8 ASN A 253
ARG A 255
GLN A 258
ILE A 274
ASN A 286
ASN A 296
GLY A 315
GLN A 317
 FMN  A 500 (-3.1A)
FMN  A 500 (-3.6A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.9A)
FMN  A 500 (-3.3A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
 0.76A 4r38B-3ue6A:
19.0		 4r38B-3ue6A:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ue6 AUREOCHROME1

(Vaucheria
frigida) 		PF13426
(PAS_9) 		7 ASN A 253
CYH A 254
ARG A 255
GLN A 258
ILE A 274
GLY A 315
GLN A 317
 FMN  A 500 (-3.1A)
FMN  A 500 (-3.5A)
FMN  A 500 (-3.6A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.9A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
 0.92A 4r38B-3ue6A:
19.0		 4r38B-3ue6A:
34.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 ALA A1246
ALA A1193
ILE A1192
ASN A1160
GLY A1243
 None
 1.02A 4r38B-3ummA:
undetectable		 4r38B-3ummA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8x TRANSFERRIN-BINDING
PROTEIN 1

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ASN A 677
ARG A 643
ASN A 737
ASN A 762
GLY A 103
 None
 1.10A 4r38B-3v8xA:
undetectable		 4r38B-3v8xA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh0 UNCHARACTERIZED
PROTEIN YNCE

(Escherichia
coli) 		no annotation 5 ALA A  58
ALA A 115
ILE A 116
ASN A 110
GLY A  69
 None
 1.09A 4r38B-3vh0A:
undetectable		 4r38B-3vh0A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv4 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
halstedii) 		PF00501
(AMP-binding) 		5 ALA A 171
ASN A  62
LEU A  61
GLY A  39
GLN A  58
 None
 1.18A 4r38B-3wv4A:
undetectable		 4r38B-3wv4A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avx HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE

(Homo sapiens) 		PF00790
(VHS)
PF01363
(FYVE) 		5 CYH A 169
ARG A 170
ALA A 163
ILE A 188
GLY A 191
 ZN  A1226 (-2.3A)
None
None
None
None
 1.09A 4r38B-4avxA:
undetectable		 4r38B-4avxA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		5 ALA P   9
ILE P  10
ASN P  78
LEU P  79
GLY P 302
 None
 1.00A 4r38B-4crmP:
undetectable		 4r38B-4crmP:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djf CORRINOID/IRON-SULFU
R PROTEIN LARGE
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD)
PF04060
(FeS) 		5 ALA C 184
ARG C 236
ALA C 266
ILE C 265
LEU C 214
 None
 1.09A 4r38B-4djfC:
undetectable		 4r38B-4djfC:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Lactobacillus
brevis) 		PF12849
(PBP_like_2) 		5 GLN A 129
ILE A 199
ASN A 217
LEU A 216
GLY A 170
 None
None
EDO  A 304 (-3.9A)
EDO  A 304 (-4.2A)
EDO  A 310 (-4.0A)
 1.12A 4r38B-4ecfA:
undetectable		 4r38B-4ecfA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ees PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		9 ASN A 425
ARG A 427
GLN A 430
ILE A 446
ASN A 458
ASN A 468
LEU A 470
GLY A 487
GLN A 489
 FMN  A1001 (-3.0A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.2A)
FMN  A1001 (-4.6A)
FMN  A1001 (-3.0A)
FMN  A1001 (-3.9A)
FMN  A1001 (-4.2A)
FMN  A1001 (-3.8A)
FMN  A1001 (-3.9A)
 0.56A 4r38B-4eesA:
19.6		 4r38B-4eesA:
35.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcz BLUE-LIGHT
PHOTORECEPTOR,
SENSOR PROTEIN FIXL

(Bacillus
subtilis;
Bradyrhizobium
diazoefficiens) 		PF00512
(HisKA)
PF02518
(HATPase_c)
PF13426
(PAS_9) 		9 ASN A  61
CYH A  62
ARG A  63
GLN A  66
ASN A  94
ASN A 104
LEU A 106
GLY A 121
GLN A 123
 FMN  A 401 (-3.1A)
FMN  A 401 (-3.3A)
FMN  A 401 (-3.9A)
FMN  A 401 (-3.2A)
FMN  A 401 (-3.1A)
FMN  A 401 (-3.7A)
FMN  A 401 (-4.3A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.75A 4r38B-4gczA:
18.4		 4r38B-4gczA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		5 ALA A 218
GLN A 226
ASN A 179
GLY A 220
GLN A 181
 None
 1.19A 4r38B-4gpgA:
undetectable		 4r38B-4gpgA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hhd PHOTOTROPIN-1

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		8 ASN A 511
ARG A 513
GLN A 516
ILE A 532
ASN A 544
ASN A 554
GLY A 573
GLN A 575
 FMN  A 701 (-2.9A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-2.8A)
FMN  A 701 (-3.8A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.65A 4r38B-4hhdA:
19.2		 4r38B-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hhd PHOTOTROPIN-1

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		7 ASN A 511
CYH A 512
ARG A 513
GLN A 516
ILE A 532
GLY A 573
GLN A 575
 FMN  A 701 (-2.9A)
FMN  A 701 (-3.7A)
FMN  A 701 (-2.6A)
FMN  A 701 (-3.3A)
FMN  A 701 (-4.7A)
FMN  A 701 (-3.7A)
FMN  A 701 (-3.6A)
 0.85A 4r38B-4hhdA:
19.2		 4r38B-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj3 LOV PROTEIN

(Rhodobacter
sphaeroides) 		PF13426
(PAS_9) 		9 ASN A  54
CYH A  55
ARG A  56
GLN A  59
ASN A  87
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 FMN  A 201 (-3.1A)
FMN  A 201 (-3.7A)
FMN  A 201 (-3.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-2.9A)
FMN  A 201 (-3.8A)
FMN  A 201 (-4.4A)
FMN  A 201 (-3.9A)
FMN  A 201 (-3.8A)
 0.77A 4r38B-4hj3A:
15.4		 4r38B-4hj3A:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 5 ALA D 236
ALA D 144
ILE D 105
GLY D  12
GLN D  84
 None
 1.17A 4r38B-4jrmD:
undetectable		 4r38B-4jrmD:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nyn RIBONUCLEASE HI

(Halobacterium
salinarum) 		PF13456
(RVT_3) 		5 ALA A 121
ALA A  85
ILE A 106
ASN A 185
GLY A 102
 None
 1.18A 4r38B-4nynA:
undetectable		 4r38B-4nynA:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		12 ALA A  23
ASN A  54
CYH A  55
ARG A  56
GLN A  59
ALA A  72
ILE A  75
ASN A  87
ASN A  97
LEU A  99
GLY A 116
GLN A 118
 RBF  A 402 ( 2.9A)
RBF  A 402 (-2.9A)
RBF  A 402 (-3.4A)
RBF  A 402 (-3.6A)
RBF  A 402 (-3.3A)
RBF  A 402 ( 3.1A)
RBF  A 402 (-4.3A)
RBF  A 402 (-2.3A)
RBF  A 402 (-4.0A)
RBF  A 402 (-4.3A)
RBF  A 402 ( 3.8A)
RBF  A 402 (-4.3A)
 0.31A 4r38B-4r3aA:
16.8		 4r38B-4r3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 ALA A  23
ASN A  54
CYH A  55
ILE A  75
ASN A  87
 RBF  A 402 ( 2.9A)
RBF  A 402 (-2.9A)
RBF  A 402 (-3.4A)
RBF  A 402 (-4.3A)
RBF  A 402 (-2.3A)
 1.06A 4r38B-4r3aA:
16.8		 4r38B-4r3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 ALA A  23
CYH A  55
ALA A  72
ILE A  75
ASN A  97
 RBF  A 402 ( 2.9A)
RBF  A 402 (-3.4A)
RBF  A 402 ( 3.1A)
RBF  A 402 (-4.3A)
RBF  A 402 (-4.0A)
 1.12A 4r38B-4r3aA:
16.8		 4r38B-4r3aA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		5 ALA A  74
GLN A 118
ALA A  23
ASN A  97
ASN A  87
 None
RBF  A 402 (-4.3A)
RBF  A 402 ( 2.9A)
RBF  A 402 (-4.0A)
RBF  A 402 (-2.3A)
 1.22A 4r38B-4r3aA:
16.8		 4r38B-4r3aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 235
ALA A 143
ILE A 104
GLY A  11
GLN A  83
 None
 0.98A 4r38B-4r8eA:
undetectable		 4r38B-4r8eA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 ALA L 472
ALA L 449
ASN L 433
LEU L 463
GLY L 500
 None
None
EDO  L 709 (-3.7A)
EDO  L 709 ( 4.5A)
None
 1.13A 4r38B-4tkxL:
undetectable		 4r38B-4tkxL:
14.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY

(Trichoderma
reesei) 		PF13426
(PAS_9) 		9 ASN A 134
CYH A 135
ARG A 136
GLN A 139
ILE A 161
ASN A 173
ASN A 183
GLY A 202
GLN A 204
 FMN  A5201 (-2.5A)
FMN  A5201 (-3.5A)
FMN  A5201 (-3.7A)
FMN  A5201 (-3.1A)
FMN  A5201 (-3.8A)
FMN  A5201 (-2.4A)
FMN  A5201 (-4.1A)
FMN  A5201 (-3.0A)
FMN  A5201 (-3.7A)
 0.78A 4r38B-4wujA:
15.5		 4r38B-4wujA:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 ALA A 264
ALA A 323
ILE A 322
GLY A 336
GLN A 371
 None
 0.96A 4r38B-4wz9A:
undetectable		 4r38B-4wz9A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 ALA A 206
ALA A 139
LEU A 124
GLY A 214
GLN A 121
 None
 1.17A 4r38B-4z2aA:
undetectable		 4r38B-4z2aA:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a8b PTAUREO1A LOV2
DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		8 ASN A 286
ARG A 288
GLN A 291
ILE A 307
ASN A 319
ASN A 329
GLY A 348
GLN A 350
 FMN  A 500 (-3.2A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.0A)
FMN  A 500 (-4.8A)
FMN  A 500 (-3.0A)
FMN  A 500 (-4.2A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.9A)
 0.74A 4r38B-5a8bA:
17.7		 4r38B-5a8bA:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a8b PTAUREO1A LOV2
DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		7 ASN A 286
CYH A 287
ARG A 288
GLN A 291
ILE A 307
GLY A 348
GLN A 350
 FMN  A 500 (-3.2A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.0A)
FMN  A 500 (-4.8A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.9A)
 0.90A 4r38B-5a8bA:
17.7		 4r38B-5a8bA:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a8b PTAUREO1A LOV2
DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		6 ASN A 286
CYH A 287
ARG A 288
ILE A 307
ASN A 319
GLY A 348
 FMN  A 500 (-3.2A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.1A)
FMN  A 500 (-4.8A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.8A)
 1.31A 4r38B-5a8bA:
17.7		 4r38B-5a8bA:
34.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9c POLYHEDRIN

(Cypovirus 4) 		PF17515
(CPV_Polyhedrin) 		5 ALA A  36
ASN A 123
ARG A 187
GLN A 188
ASN A 193
 None
 1.21A 4r38B-5a9cA:
undetectable		 4r38B-5a9cA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 ALA A 293
ILE A 294
ASN A  26
GLY A 219
GLN A  28
 None
 1.13A 4r38B-5cnxA:
undetectable		 4r38B-5cnxA:
17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dju NPH1-2

(Avena sativa) 		PF13426
(PAS_9) 		8 ASN A 449
ARG A 451
GLN A 454
ILE A 470
ASN A 482
ASN A 492
GLY A 511
GLN A 513
 FMN  A 601 ( 3.1A)
FMN  A 601 ( 3.8A)
FMN  A 601 (-3.1A)
CL  A 603 (-4.4A)
FMN  A 601 (-3.1A)
FMN  A 601 (-3.9A)
FMN  A 601 (-3.8A)
FMN  A 601 (-3.8A)
 0.62A 4r38B-5djuA:
17.2		 4r38B-5djuA:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dkk LOV DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		8 ASN A 286
ARG A 288
GLN A 291
ILE A 307
ASN A 319
ASN A 329
GLY A 348
GLN A 350
 FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.86A 4r38B-5dkkA:
17.5		 4r38B-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dkk LOV DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		7 ASN A 286
CYH A 287
ARG A 288
GLN A 291
ILE A 307
GLY A 348
GLN A 350
 FMN  A 401 (-3.0A)
FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.96A 4r38B-5dkkA:
17.5		 4r38B-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dkk LOV DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		6 ASN A 286
CYH A 287
ARG A 288
ILE A 307
ASN A 319
GLY A 348
 FMN  A 401 (-3.0A)
FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.0A)
FMN  A 401 (-3.7A)
 1.29A 4r38B-5dkkA:
17.5		 4r38B-5dkkA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE
PROTEASOME, PUTATIVE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 ALA H 166
ALA N  35
LEU N  58
GLY H 171
GLN N  62
 None
 0.91A 4r38B-5fmgH:
undetectable		 4r38B-5fmgH:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ALA C 622
ILE C 475
ASN C 442
GLY C 691
GLN C 509
 MCN  C 921 ( 3.7A)
MCN  C 921 ( 4.3A)
None
MCN  C 921 (-3.6A)
None
 1.17A 4r38B-5g5gC:
undetectable		 4r38B-5g5gC:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		8 ASN A  96
ARG A  98
GLN A 101
ILE A 117
ASN A 129
ASN A 139
GLY A 158
GLN A 160
 FMN  A 402 (-3.2A)
FMN  A 402 (-3.3A)
FMN  A 402 (-2.9A)
FMN  A 402 (-4.8A)
FMN  A 402 (-2.9A)
FMN  A 402 (-4.2A)
FMN  A 402 (-3.7A)
FMN  A 402 (-3.6A)
 0.59A 4r38B-5hzhA:
17.4		 4r38B-5hzhA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		8 ASN B1354
ARG B1356
GLN B1359
ILE B1375
ASN B1387
ASN B1397
GLY B1416
GLN B1418
 FMN  B1801 (-3.0A)
FMN  B1801 (-3.9A)
FMN  B1801 (-3.0A)
FMN  B1801 (-4.9A)
FMN  B1801 (-3.0A)
FMN  B1801 (-4.2A)
FMN  B1801 (-3.7A)
FMN  B1801 (-3.7A)
 0.74A 4r38B-5hzkB:
17.9		 4r38B-5hzkB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		6 ASN B1354
CYH B1355
ARG B1356
GLN B1359
GLY B1416
GLN B1418
 FMN  B1801 (-3.0A)
FMN  B1801 (-3.5A)
FMN  B1801 (-3.9A)
FMN  B1801 (-3.0A)
FMN  B1801 (-3.7A)
FMN  B1801 (-3.7A)
 1.05A 4r38B-5hzkB:
17.9		 4r38B-5hzkB:
13.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j3w SENSORY BOX PROTEIN

(Pseudomonas
putida) 		PF13426
(PAS_9) 		9 ALA A  21
CYH A  53
ARG A  54
GLN A  57
ASN A  85
ASN A  95
LEU A  97
GLY A 114
GLN A 116
 FMN  A 500 (-3.6A)
FMN  A 500 (-3.6A)
FMN  A 500 (-3.5A)
FMN  A 500 (-4.0A)
FMN  A 500 (-3.0A)
FMN  A 500 (-4.3A)
FMN  A 500 (-4.2A)
FMN  A 500 (-3.8A)
FMN  A 500 (-4.5A)
 0.63A 4r38B-5j3wA:
17.4		 4r38B-5j3wA:
38.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 ALA A 265
ALA A 327
ILE A 326
GLY A 340
GLN A 375
 None
 1.04A 4r38B-5j6sA:
undetectable		 4r38B-5j6sA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		5 ASN A  21
ALA A  52
ILE A  15
ASN A 202
GLY A 205
 None
EDO  A 601 (-3.4A)
None
None
None
 1.25A 4r38B-5khaA:
undetectable		 4r38B-5khaA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  96
ALA A 120
ILE A 119
ASN A  85
ASN A 126
 None
 1.13A 4r38B-5mfbA:
undetectable		 4r38B-5mfbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 5 ALA A 218
ALA A 193
ILE A 224
GLY A  66
GLN A 447
 SNN  A 176 ( 4.2A)
None
None
SNN  A 176 ( 3.7A)
SNN  A 176 (-3.0A)
 1.24A 4r38B-5nijA:
undetectable		 4r38B-5nijA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nus P34

(Chaetomium
thermophilum) 		no annotation 5 ALA A 157
ALA A 233
ILE A 232
ASN A  66
GLN A  67
 None
 1.12A 4r38B-5nusA:
undetectable		 4r38B-5nusA:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5svw ADAGIO PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 9 ASN B  53
CYH B  54
ARG B  55
GLN B  58
ILE B  83
ASN B  95
ASN B 105
LEU B 107
GLN B 126
 FMN  B5201 (-2.9A)
FMN  B5201 (-3.3A)
FMN  B5201 (-3.8A)
FMN  B5201 (-3.1A)
FMN  B5201 (-4.2A)
FMN  B5201 (-2.4A)
FMN  B5201 (-3.8A)
FMN  B5201 ( 4.5A)
FMN  B5201 (-3.8A)
 0.98A 4r38B-5svwB:
17.3		 4r38B-5svwB:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5svw ADAGIO PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 9 ASN B  53
CYH B  54
ARG B  55
GLN B  58
ILE B  83
ASN B  95
ASN B 105
LEU B 107
GLY B 124
 FMN  B5201 (-2.9A)
FMN  B5201 (-3.3A)
FMN  B5201 (-3.8A)
FMN  B5201 (-3.1A)
FMN  B5201 (-4.2A)
FMN  B5201 (-2.4A)
FMN  B5201 (-3.8A)
FMN  B5201 ( 4.5A)
FMN  B5201 (-3.0A)
 0.71A 4r38B-5svwB:
17.3		 4r38B-5svwB:
32.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		5 ALA O 916
ILE O 892
ASN O 783
LEU O 809
GLY O 817
 None
 1.23A 4r38B-5x0yO:
undetectable		 4r38B-5x0yO:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 5 ALA A 276
ALA A 340
ILE A 339
GLY A 353
GLN A 388
 None
 0.98A 4r38B-6bv2A:
undetectable		 4r38B-6bv2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbv PUTATIVE BLUE-LIGHT
PHOTORECEPTOR

(Dinoroseobacter
shibae) 		no annotation 5 ALA A  87
ASN A 104
LEU A 116
GLY A 133
GLN A 135
 None
FMN  A 500 (-3.0A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.8A)
 1.16A 4r38B-6gbvA:
18.4		 4r38B-6gbvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbv PUTATIVE BLUE-LIGHT
PHOTORECEPTOR

(Dinoroseobacter
shibae) 		no annotation 7 ASN A  71
ARG A  73
ASN A 104
ASN A 114
LEU A 116
GLY A 133
GLN A 135
 FMN  A 500 ( 3.2A)
FMN  A 500 (-4.5A)
FMN  A 500 (-3.0A)
FMN  A 500 (-4.0A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.8A)
 0.79A 4r38B-6gbvA:
18.4		 4r38B-6gbvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbv PUTATIVE BLUE-LIGHT
PHOTORECEPTOR

(Dinoroseobacter
shibae) 		no annotation 6 ASN A  71
ARG A  73
GLN A  76
ASN A 104
GLY A 133
GLN A 135
 FMN  A 500 ( 3.2A)
FMN  A 500 (-4.5A)
FMN  A 500 (-4.2A)
FMN  A 500 (-3.0A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.8A)
 1.04A 4r38B-6gbvA:
18.4		 4r38B-6gbvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbv PUTATIVE BLUE-LIGHT
PHOTORECEPTOR

(Dinoroseobacter
shibae) 		no annotation 7 ASN A  71
CYH A  72
ARG A  73
ASN A 104
LEU A 116
GLY A 133
GLN A 135
 FMN  A 500 ( 3.2A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.5A)
FMN  A 500 (-3.0A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.8A)
 0.95A 4r38B-6gbvA:
18.4		 4r38B-6gbvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b47 CBL

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		4 GLU A  57
LEU A  88
LEU A  95
MET A 119
 None
 0.95A 4r38B-1b47A:
1.5		 4r38B-1b47A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 THR A 353
GLU A 364
LEU A 361
VAL A 314
LEU A 319
 None
 1.36A 4r38B-1bdgA:
0.0		 4r38B-1bdgA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by8 PROTEIN
(PROCATHEPSIN K)

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 THR A 141
LEU A 145
VAL A 130
LEU A 133
MET A 314
 None
 1.32A 4r38B-1by8A:
0.0		 4r38B-1by8A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		4 THR A 608
ILE A 575
LEU A 591
LEU A 539
 None
 0.84A 4r38B-1ciiA:
0.0		 4r38B-1ciiA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		4 THR A 482
ILE A 477
LEU A 437
VAL A 386
 None
 0.97A 4r38B-1clwA:
2.1		 4r38B-1clwA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8k GENERAL
TRANSCRIPTION FACTOR
TFIIE-BETA

(Homo sapiens) 		PF02186
(TFIIE_beta) 		4 THR A  41
GLU A  36
LEU A  54
MET A  20
 None
 0.97A 4r38B-1d8kA:
undetectable		 4r38B-1d8kA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8k GENERAL
TRANSCRIPTION FACTOR
TFIIE-BETA

(Homo sapiens) 		PF02186
(TFIIE_beta) 		4 THR A  41
LEU A  54
VAL A  67
MET A  20
 None
 0.83A 4r38B-1d8kA:
undetectable		 4r38B-1d8kA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ILE A 166
LEU A  12
VAL A 160
PHE A 167
 None
 0.97A 4r38B-1e5dA:
0.0		 4r38B-1e5dA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7c RHOGAP PROTEIN

(Gallus gallus) 		PF00620
(RhoGAP) 		4 GLU A 306
LEU A 315
VAL A 301
LEU A 304
 None
 0.86A 4r38B-1f7cA:
undetectable		 4r38B-1f7cA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnn CELL DIVISION
CONTROL PROTEIN 6

(Pyrobaculum
aerophilum) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 ILE A 277
GLU A 370
VAL A 273
LEU A 274
 None
 0.95A 4r38B-1fnnA:
0.0		 4r38B-1fnnA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 THR A 453
ILE A 440
LEU A 182
PHE A 160
 None
 0.99A 4r38B-1g8kA:
0.0		 4r38B-1g8kA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 ILE A 173
LEU A 325
VAL A 333
PHE A 299
 None
 0.93A 4r38B-1gl6A:
undetectable		 4r38B-1gl6A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 ILE A  88
GLU A  43
LEU A 293
VAL A 119
 None
 0.97A 4r38B-1h54A:
1.4		 4r38B-1h54A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		4 ILE A 252
LEU A 268
LEU A 281
PHE A 241
 None
 1.02A 4r38B-1hdiA:
undetectable		 4r38B-1hdiA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 THR A 202
ILE A 154
VAL A 120
LEU A 123
 None
 1.01A 4r38B-1hkwA:
undetectable		 4r38B-1hkwA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 THR A  63
ILE A  59
VAL A 107
LEU A 244
 None
 0.96A 4r38B-1jcnA:
undetectable		 4r38B-1jcnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1klp MEROMYCOLATE
EXTENSION ACYL
CARRIER PROTEIN

(Mycobacterium
tuberculosis) 		PF00550
(PP-binding) 		4 THR A  51
LEU A  67
VAL A  34
LEU A  37
 None
 0.91A 4r38B-1klpA:
undetectable		 4r38B-1klpA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kng THIOL:DISULFIDE
INTERCHANGE PROTEIN
CYCY

(Bradyrhizobium
japonicum) 		PF08534
(Redoxin) 		4 ILE A 168
LEU A 186
LEU A 172
PHE A 160
 None
 0.83A 4r38B-1kngA:
undetectable		 4r38B-1kngA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks9 2-DEHYDROPANTOATE
2-REDUCTASE

(Escherichia
coli) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 THR A  70
ILE A 139
LEU A  16
LEU A 160
 None
 0.94A 4r38B-1ks9A:
undetectable		 4r38B-1ks9A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2x CLASS B
CARBAPENEMASE BLAB-1

(Elizabethkingia
meningoseptica) 		PF00753
(Lactamase_B) 		4 ILE A 113
LEU A  48
VAL A  75
LEU A  74
 None
 0.96A 4r38B-1m2xA:
undetectable		 4r38B-1m2xA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox)
PF02964
(MeMO_Hyd_G) 		4 THR B  91
LEU B 320
VAL G  75
LEU G  78
 None
 0.93A 4r38B-1mhyB:
undetectable		 4r38B-1mhyB:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1q DPS PROTEIN

(Brevibacillus
brevis) 		PF00210
(Ferritin) 		4 LEU A  12
VAL A  17
LEU A  60
MET A 129
 None
 0.98A 4r38B-1n1qA:
undetectable		 4r38B-1n1qA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni6 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		4 ILE A  65
LEU A  54
VAL A 115
LEU A 118
 None
 0.99A 4r38B-1ni6A:
undetectable		 4r38B-1ni6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nij HYPOTHETICAL PROTEIN
YJIA

(Escherichia
coli) 		PF02492
(cobW)
PF07683
(CobW_C) 		4 THR A  55
ILE A  89
VAL A  95
LEU A  94
 None
 0.93A 4r38B-1nijA:
undetectable		 4r38B-1nijA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 ILE A 485
LEU A 446
VAL A 153
LEU A 156
 None
 0.93A 4r38B-1nr6A:
undetectable		 4r38B-1nr6A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oed ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN
ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02932
(Neur_chan_memb) 		4 GLU A 262
LEU A 253
VAL B 261
LEU B 264
 None
 0.92A 4r38B-1oedA:
undetectable		 4r38B-1oedA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		4 GLU B 459
LEU B 467
VAL B 451
LEU B 454
 None
 0.99A 4r38B-1ox4B:
undetectable		 4r38B-1ox4B:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 THR A 381
ILE A 423
VAL A 434
LEU A 433
 None
 0.97A 4r38B-1p31A:
undetectable		 4r38B-1p31A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		4 ILE A 192
LEU A 144
MET A  21
PHE A  17
 FAD  A 501 (-4.5A)
None
None
FAD  A 501 (-4.9A)
 0.85A 4r38B-1qbgA:
undetectable		 4r38B-1qbgA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4k ARGONAUTE 1

(Drosophila
melanogaster) 		PF02170
(PAZ) 		4 THR A 334
ILE A 342
LEU A 313
LEU A 416
 None
 1.00A 4r38B-1r4kA:
undetectable		 4r38B-1r4kA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcw CT610

(Chlamydia
trachomatis) 		PF03070
(TENA_THI-4) 		4 ILE A 145
LEU A  78
VAL A 135
LEU A 138
 None
 0.83A 4r38B-1rcwA:
undetectable		 4r38B-1rcwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rg6 SECOND SPLICE
VARIANT P63

(Homo sapiens) 		PF07647
(SAM_2) 		4 LEU A  31
VAL A  11
LEU A  14
PHE A  54
 None
 1.00A 4r38B-1rg6A:
undetectable		 4r38B-1rg6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0h VOLTAGE-GATED
CALCIUM CHANNEL
SUBUNIT BETA2A

(Rattus
norvegicus) 		PF00625
(Guanylate_kin) 		4 THR B 322
ILE B 338
LEU B 272
LEU B 334
 None
 1.01A 4r38B-1t0hB:
undetectable		 4r38B-1t0hB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 THR A 477
LEU A 438
VAL A 443
LEU A 442
 None
 0.89A 4r38B-1t1uA:
undetectable		 4r38B-1t1uA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tba TRANSCRIPTION
INITIATION FACTOR
TFIID

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		4 ILE B 146
LEU B 114
LEU B  82
PHE B 148
 None
 1.01A 4r38B-1tbaB:
undetectable		 4r38B-1tbaB:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tbu PEROXISOMAL
ACYL-COENZYME A
THIOESTER HYDROLASE
1

(Saccharomyces
cerevisiae) 		PF13622
(4HBT_3) 		4 THR A  40
ILE A  14
VAL A  18
LEU A  17
 None
 1.01A 4r38B-1tbuA:
undetectable		 4r38B-1tbuA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		5 THR A  28
ILE A 246
GLU A 242
LEU A 239
PHE A 243
 None
 1.41A 4r38B-1tcdA:
undetectable		 4r38B-1tcdA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkp IRON-RICH
DPSA-HOMOLOG PROTEIN

(Halobacterium
salinarum) 		PF00210
(Ferritin) 		4 LEU A  20
VAL A  31
LEU A  34
MET A 151
 None
 1.01A 4r38B-1tkpA:
undetectable		 4r38B-1tkpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		4 THR A 195
LEU A  31
LEU A  21
PHE A  89
 APR  A 285 (-3.6A)
None
None
APR  A 285 ( 4.9A)
 0.98A 4r38B-1txzA:
undetectable		 4r38B-1txzA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz9 MANNONATE
DEHYDRATASE

(Enterococcus
faecalis) 		PF03786
(UxuA) 		4 ILE A 194
LEU A 228
VAL A 183
LEU A 186
 None
 1.00A 4r38B-1tz9A:
undetectable		 4r38B-1tz9A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz8 IGG FAB (IGG3,
KAPPA) HEAVY CHAIN
291-2G3-A

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE B  48
LEU B 109
MET B  82
PHE B  67
 None
 0.91A 4r38B-1uz8B:
undetectable		 4r38B-1uz8B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4v UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Thermus
thermophilus) 		PF02350
(Epimerase_2) 		4 THR A 177
GLU A  17
VAL A  38
LEU A  10
 None
 1.01A 4r38B-1v4vA:
undetectable		 4r38B-1v4vA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		4 THR A  27
ILE A 161
LEU A  73
PHE A   4
 None
 0.87A 4r38B-1vpxA:
undetectable		 4r38B-1vpxA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyt CALCIUM CHANNEL
BETA-3 SUBUNIT

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		4 THR A 273
ILE A 289
LEU A 223
LEU A 285
 None
 0.98A 4r38B-1vytA:
undetectable		 4r38B-1vytA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6

(Homo sapiens) 		PF00307
(CH) 		4 ILE A  28
LEU A 108
LEU A  15
PHE A  34
 None
 0.96A 4r38B-1wyrA:
undetectable		 4r38B-1wyrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7f OUTER SURFACE
PROTEIN

(Bacillus cereus) 		PF05913
(DUF871) 		4 ILE A  96
LEU A   9
LEU A  38
PHE A  88
 None
 0.99A 4r38B-1x7fA:
undetectable		 4r38B-1x7fA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdz METHYLTRANSFERASE
GIDB

(Bacillus
subtilis) 		PF02527
(GidB) 		4 THR A 221
ILE A 218
LEU A 162
VAL A 170
 None
 0.99A 4r38B-1xdzA:
undetectable		 4r38B-1xdzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbd RABPHILIN-3A

(Rattus
norvegicus) 		PF00071
(Ras) 		4 ILE A  71
LEU A  39
LEU A 179
PHE A  23
 None
 0.97A 4r38B-1zbdA:
undetectable		 4r38B-1zbdA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		4 ILE A  64
LEU A 134
VAL A  99
PHE A 106
 None
 1.02A 4r38B-1zupA:
undetectable		 4r38B-1zupA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 THR A 148
LEU A 107
VAL A 154
LEU A 153
 None
 0.86A 4r38B-2a7nA:
undetectable		 4r38B-2a7nA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum) 		PF00378
(ECH_1) 		4 THR A 148
ILE A 215
VAL A  83
MET A 115
 None
None
BCN  A 501 (-4.6A)
None
 1.02A 4r38B-2a81A:
undetectable		 4r38B-2a81A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akp ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A  35
LEU A 185
VAL A 208
LEU A 207
 None
 0.96A 4r38B-2akpA:
undetectable		 4r38B-2akpA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amy PHOSPHOMANNOMUTASE 2

(Homo sapiens) 		PF03332
(PMM) 		4 THR A 237
ILE A  41
VAL A  52
LEU A  56
 None
 0.96A 4r38B-2amyA:
undetectable		 4r38B-2amyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2an1 PUTATIVE KINASE

(Salmonella
enterica) 		PF01513
(NAD_kinase) 		4 THR A 183
LEU A  77
VAL A  90
LEU A 269
 THR  A 183 ( 0.8A)
LEU  A  77 ( 0.6A)
VAL  A  90 ( 0.6A)
LEU  A 269 ( 0.6A)
 0.94A 4r38B-2an1A:
undetectable		 4r38B-2an1A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anu HYPOTHETICAL PROTEIN
TM0559

(Thermotoga
maritima) 		no annotation 4 THR A  51
ILE A  46
LEU A 104
VAL A 122
 None
 0.89A 4r38B-2anuA:
undetectable		 4r38B-2anuA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 THR A 877
VAL A 715
LEU A 712
MET A 895
 BHM  A   1 (-3.0A)
None
None
None
 0.91A 4r38B-2ax9A:
undetectable		 4r38B-2ax9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		4 ILE A  22
LEU A  29
MET A  77
PHE A  75
 None
 0.99A 4r38B-2az3A:
undetectable		 4r38B-2az3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be3 GTP
PYROPHOSPHOKINASE

(Streptococcus
pneumoniae) 		PF04607
(RelA_SpoT) 		4 ILE A 142
LEU A 137
VAL A  16
LEU A  19
 None
 0.83A 4r38B-2be3A:
undetectable		 4r38B-2be3A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bj8 NICKEL RESPONSIVE
REGULATOR

(Pyrococcus
horikoshii) 		PF01402
(RHH_1)
PF08753
(NikR_C) 		4 ILE A  84
LEU A  98
VAL A  70
LEU A  73
 None
 0.96A 4r38B-2bj8A:
undetectable		 4r38B-2bj8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		4 ILE A 114
VAL A 227
LEU A 230
PHE A 167
 None
 0.94A 4r38B-2c20A:
undetectable		 4r38B-2c20A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ILE A  35
LEU A 185
VAL A 208
LEU A 207
 None
 0.97A 4r38B-2cg9A:
undetectable		 4r38B-2cg9A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		4 THR A 134
ILE A 156
LEU A 167
PHE A 109
 None
None
BR  A 801 ( 4.1A)
HEM  A 396 (-4.5A)
 1.00A 4r38B-2ciyA:
undetectable		 4r38B-2ciyA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		4 GLU A 175
LEU A 230
VAL A 200
LEU A 254
 None
 0.97A 4r38B-2cw5A:
undetectable		 4r38B-2cw5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		4 GLU A  15
LEU A 252
VAL A 208
LEU A 207
 None
 0.96A 4r38B-2cybA:
undetectable		 4r38B-2cybA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		4 GLU A  15
VAL A 208
LEU A 207
MET A  51
 None
 0.82A 4r38B-2cybA:
undetectable		 4r38B-2cybA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czd OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrococcus
horikoshii) 		PF00215
(OMPdecase) 		4 ILE A  63
LEU A  99
VAL A  84
LEU A  60
 None
 0.91A 4r38B-2czdA:
undetectable		 4r38B-2czdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt9 ASPARTOKINASE

(Thermus
thermophilus) 		PF01842
(ACT)
PF13840
(ACT_7) 		5 ILE A 129
LEU A  12
VAL A 101
MET A 115
PHE A 116
 None
 1.18A 4r38B-2dt9A:
undetectable		 4r38B-2dt9A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		4 THR A 215
ILE A  35
VAL A  62
LEU A  13
 None
 0.98A 4r38B-2dwuA:
undetectable		 4r38B-2dwuA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		4 ILE A 749
LEU A 780
MET A 834
PHE A 752
 None
 0.91A 4r38B-2ec5A:
undetectable		 4r38B-2ec5A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		4 ILE A 173
VAL A 202
LEU A 184
PHE A 181
 None
 0.99A 4r38B-2ehhA:
undetectable		 4r38B-2ehhA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ets HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF08807
(DUF1798) 		4 GLU A  80
VAL A  98
LEU A  95
PHE A  19
 None
 0.95A 4r38B-2etsA:
undetectable		 4r38B-2etsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151

(Pyrobaculum
aerophilum) 		PF01850
(PIN) 		4 THR A  97
LEU A  38
VAL A   4
LEU A 114
 None
 1.02A 4r38B-2fe1A:
undetectable		 4r38B-2fe1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffs HYPOTHETICAL PROTEIN
PA1206

(Pseudomonas
aeruginosa) 		PF08982
(DUF1857) 		4 THR A 141
LEU A  94
VAL A  67
LEU A  60
 None
 0.99A 4r38B-2ffsA:
undetectable		 4r38B-2ffsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fki PROTEIN YJBR

(Escherichia
coli) 		PF04237
(YjbR) 		4 GLU A 109
LEU A 118
VAL A 104
LEU A 107
 None
 0.79A 4r38B-2fkiA:
undetectable		 4r38B-2fkiA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf9 RAS-RELATED PROTEIN
RAB-3D

(Homo sapiens) 		PF00071
(Ras) 		5 ILE A  71
LEU A  39
VAL A 175
LEU A 179
PHE A  23
 None
 1.21A 4r38B-2gf9A:
undetectable		 4r38B-2gf9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn4 UDP-GLCNAC C6
DEHYDRATASE

(Helicobacter
pylori) 		PF02719
(Polysacc_synt_2) 		5 ILE A 284
GLU A 228
LEU A 218
LEU A 302
PHE A 279
 None
 1.37A 4r38B-2gn4A:
undetectable		 4r38B-2gn4A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		4 GLU A 271
LEU A 305
VAL A 320
LEU A 324
 None
 1.01A 4r38B-2hcbA:
undetectable		 4r38B-2hcbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 422
VAL A 365
LEU A 368
PHE A 389
 None
 0.97A 4r38B-2hnzA:
undetectable		 4r38B-2hnzA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		4 ILE A 209
LEU A 340
VAL A  34
LEU A 163
 None
 0.93A 4r38B-2inrA:
undetectable		 4r38B-2inrA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu5 HTH-TYPE DHAKLM
OPERON
TRANSCRIPTIONAL
ACTIVATOR DHAS

(Lactococcus
lactis) 		PF00440
(TetR_N) 		4 ILE A 119
LEU A  82
VAL A 168
LEU A 171
 None
 0.77A 4r38B-2iu5A:
undetectable		 4r38B-2iu5A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 THR A 751
GLU A 731
LEU A 464
PHE A 728
 None
 0.92A 4r38B-2iujA:
undetectable		 4r38B-2iujA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv8 AP-2 COMPLEX SUBUNIT
BETA-1

(Homo sapiens) 		PF02883
(Alpha_adaptinC2)
PF09066
(B2-adapt-app_C) 		4 ILE A 899
LEU A 819
VAL A 824
LEU A 825
 None
 1.02A 4r38B-2iv8A:
1.9		 4r38B-2iv8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivx CYCLIN-T2

(Homo sapiens) 		PF00134
(Cyclin_N) 		4 GLU A 239
LEU A 230
VAL A 194
PHE A 240
 None
 1.01A 4r38B-2ivxA:
undetectable		 4r38B-2ivxA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Sulfolobus
solfataricus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE A 211
GLU A 210
LEU A 175
LEU A 181
 None
 0.92A 4r38B-2izoA:
undetectable		 4r38B-2izoA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		4 ILE A 488
LEU A 449
VAL A 153
LEU A 156
 None
 0.82A 4r38B-2nnjA:
undetectable		 4r38B-2nnjA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nux 2-KETO-3-DEOXYGLUCON
ATE/2-KETO-3-DEOXY-6
-PHOSPHO GLUCONATE
ALDOLASE

(Sulfolobus
acidocaldarius) 		PF00701
(DHDPS) 		4 ILE A  92
LEU A  49
VAL A  80
LEU A  83
 None
 1.02A 4r38B-2nuxA:
undetectable		 4r38B-2nuxA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
NEDD8-CONJUGATING
ENZYME UBC12

(Homo sapiens) 		PF00179
(UQ_con)
PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		4 ILE B2400
LEU C  32
VAL C  82
LEU C  58
 None
 1.00A 4r38B-2nvuB:
undetectable		 4r38B-2nvuB:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN

(Shewanella
oneidensis) 		PF08933
(DUF1864) 		4 THR A 190
ILE A 242
LEU A 287
LEU A 251
 None
HEM  A 401 (-3.7A)
None
None
 0.96A 4r38B-2nwbA:
undetectable		 4r38B-2nwbA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 KIT LIGAND

(Mus musculus) 		PF02404
(SCF) 		4 ILE A  15
VAL A  49
LEU A  52
PHE A 116
 None
 0.94A 4r38B-2o26A:
undetectable		 4r38B-2o26A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ILE A 462
LEU A 571
VAL A 491
LEU A 492
 None
 1.00A 4r38B-2ongA:
undetectable		 4r38B-2ongA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN

(Homo sapiens) 		PF02545
(Maf) 		5 THR A 123
ILE A 127
VAL A  37
LEU A  17
PHE A 204
 None
 1.43A 4r38B-2p5xA:
1.7		 4r38B-2p5xA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pls CBS DOMAIN PROTEIN

(Chlorobaculum
tepidum) 		PF03471
(CorC_HlyC) 		4 THR A 402
GLU A 405
VAL A 361
LEU A 364
 None
 0.87A 4r38B-2plsA:
undetectable		 4r38B-2plsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q04 ACETOIN UTILIZATION
PROTEIN

(Exiguobacterium
sibiricum) 		PF00583
(Acetyltransf_1) 		4 ILE A  72
LEU A 116
LEU A  11
PHE A 106
 None
 0.95A 4r38B-2q04A:
undetectable		 4r38B-2q04A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		4 THR A  50
ILE A 375
GLU A 374
LEU A 329
 None
 0.94A 4r38B-2qa1A:
undetectable		 4r38B-2qa1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh5 MANNOSE-6-PHOSPHATE
ISOMERASE

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		4 ILE A 153
VAL A 190
MET A 249
PHE A 164
 None
 0.99A 4r38B-2qh5A:
undetectable		 4r38B-2qh5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLU A  65
LEU A  99
VAL A 108
LEU A 111
 None
 0.82A 4r38B-2qq6A:
undetectable		 4r38B-2qq6A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 GLU A 380
LEU A 471
VAL A 386
LEU A 387
 None
 0.96A 4r38B-2qveA:
undetectable		 4r38B-2qveA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 ILE A 729
LEU A 662
LEU A 656
PHE A 741
 None
None
MN  A 757 ( 4.7A)
None
 0.97A 4r38B-2qvwA:
undetectable		 4r38B-2qvwA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 THR A 701
ILE A 707
LEU A 814
PHE A 704
 None
 1.00A 4r38B-2r6fA:
undetectable		 4r38B-2r6fA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 ILE A 137
LEU A 109
LEU A 189
MET A 120
 None
 0.97A 4r38B-2v25A:
undetectable		 4r38B-2v25A:
21.48