SIMILAR PATTERNS OF AMINO ACIDS FOR 4R38_A_RBFA201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		4 LEU A 111
VAL A  26
LEU A  29
ILE A 117
 None
 0.78A 4r38A-1efpA:
undetectable		 4r38A-1efpA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvz KALLIKREIN-1E2

(Equus caballus) 		PF00089
(Trypsin) 		4 ILE A 242
VAL A  85
LEU A 108
ILE A  66
 ACT  A1250 ( 4.1A)
None
None
None
 0.81A 4r38A-1gvzA:
undetectable		 4r38A-1gvzA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jnu PHY3 PROTEIN

(Adiantum
capillus-veneris) 		PF13426
(PAS_9) 		4 ASN A 965
LEU A 969
VAL A 979
PHE A1025
 FMN  A1033 (-3.2A)
FMN  A1033 (-4.1A)
FMN  A1033 ( 4.9A)
FMN  A1033 ( 4.6A)
 0.75A 4r38A-1jnuA:
19.5		 4r38A-1jnuA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n9l PUTATIVE BLUE LIGHT
RECEPTOR

(Chlamydomonas
reinhardtii) 		PF13426
(PAS_9) 		4 ASN A  56
LEU A  60
VAL A  70
PHE A 116
 FMN  A 500 (-2.9A)
FMN  A 500 (-4.3A)
FMN  A 500 (-4.3A)
FMN  A 500 (-4.8A)
 0.51A 4r38A-1n9lA:
19.6		 4r38A-1n9lA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 ILE A 190
VAL A 261
LEU A 231
ILE A 281
 None
 0.82A 4r38A-1nhcA:
undetectable		 4r38A-1nhcA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT

(Homo sapiens) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE B 257
LEU B 276
VAL B 295
ILE B 307
 None
 0.75A 4r38A-1olxB:
undetectable		 4r38A-1olxB:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sw6 REGULATORY PROTEIN
SWI6

(Saccharomyces
cerevisiae) 		PF00023
(Ank)
PF13857
(Ank_5) 		4 ILE A 498
LEU A 480
LEU A 489
ILE A 485
 None
 0.74A 4r38A-1sw6A:
undetectable		 4r38A-1sw6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ASN A 190
VAL A 284
LEU A 285
PHE A 194
 None
 0.82A 4r38A-1tveA:
undetectable		 4r38A-1tveA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 OUTER CAPSID PROTEIN
P8

(Rice dwarf
virus) 		no annotation 4 ILE P 400
LEU P 410
LEU P 352
ILE P  72
 None
 0.67A 4r38A-1uf2P:
undetectable		 4r38A-1uf2P:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 THR A 581
LEU A 605
LEU A 669
ILE A 641
 None
 0.81A 4r38A-1v7vA:
undetectable		 4r38A-1v7vA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 ILE B 192
VAL B 136
LEU B 142
ILE B  93
 None
 0.78A 4r38A-1w85B:
undetectable		 4r38A-1w85B:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0v PUTATIVE PROTEASE LA
HOMOLOG TYPE

(Archaeoglobus
fulgidus) 		PF05362
(Lon_C) 		4 ILE A 469
VAL A 543
LEU A 537
ILE A 592
 None
 0.82A 4r38A-1z0vA:
undetectable		 4r38A-1z0vA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aky ADENYLATE KINASE

(Saccharomyces
cerevisiae) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 THR A 110
ILE A   5
LEU A  88
ILE A  72
 None
 0.77A 4r38A-2akyA:
undetectable		 4r38A-2akyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2anc GUANYLATE KINASE

(Escherichia
coli) 		PF00625
(Guanylate_kin) 		4 LEU A 166
LEU A 179
ILE A 121
PHE A 172
 None
 0.75A 4r38A-2ancA:
undetectable		 4r38A-2ancA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5e PROTEIN
DISULFIDE-ISOMERASE

(Saccharomyces
cerevisiae) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		4 ILE A  88
LEU A  53
ILE A 131
PHE A  56
 None
 0.69A 4r38A-2b5eA:
undetectable		 4r38A-2b5eA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c94 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00885
(DMRL_synthase) 		4 LEU A  79
VAL A  97
LEU A 101
ILE A  62
 None
 0.79A 4r38A-2c94A:
undetectable		 4r38A-2c94A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6x (S)-3-O-GERANYLGERAN
YLGLYCERYL PHOSPHATE
SYNTHASE

(Archaeoglobus
fulgidus) 		PF01884
(PcrB) 		4 THR A1229
ILE A1213
LEU A1012
ILE A1022
 None
1GP  A3001 ( 4.6A)
None
None
 0.82A 4r38A-2f6xA:
undetectable		 4r38A-2f6xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1

(Escherichia
coli) 		PF08013
(Tagatose_6_P_K) 		4 ILE A 407
LEU A  42
LEU A  31
ILE A  82
 None
 0.76A 4r38A-2fiqA:
undetectable		 4r38A-2fiqA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf9 RAS-RELATED PROTEIN
RAB-3D

(Homo sapiens) 		PF00071
(Ras) 		5 ILE A  71
LEU A  39
VAL A 175
LEU A 179
PHE A  23
 None
 1.19A 4r38A-2gf9A:
undetectable		 4r38A-2gf9A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 ILE A 688
LEU A 624
LEU A 618
ILE A 633
 None
 0.78A 4r38A-2h5gA:
undetectable		 4r38A-2h5gA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mwg BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF01740
(STAS)
PF13426
(PAS_9) 		4 ASN A  61
LEU A  65
VAL A  75
ILE A  92
 FMN  A 900 (-2.0A)
FMN  A 900 ( 4.1A)
None
FMN  A 900 ( 4.1A)
 0.47A 4r38A-2mwgA:
6.5		 4r38A-2mwgA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppg PUTATIVE ISOMERASE

(Sinorhizobium
meliloti) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 128
VAL A 368
LEU A 329
ILE A 154
 None
 0.71A 4r38A-2ppgA:
undetectable		 4r38A-2ppgA:
15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pr5 BLUE-LIGHT
PHOTORECEPTOR

(Bacillus
subtilis) 		PF13426
(PAS_9) 		5 ASN A  61
LEU A  65
VAL A  75
ILE A  92
PHE A 119
 FMN  A 500 (-3.2A)
FMN  A 500 (-4.4A)
FMN  A 500 (-4.6A)
FMN  A 500 ( 4.6A)
FMN  A 500 ( 4.8A)
 0.67A 4r38A-2pr5A:
17.9		 4r38A-2pr5A:
40.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 THR A 147
ILE A 206
LEU A 185
ILE A 281
 None
 0.81A 4r38A-2pwzA:
undetectable		 4r38A-2pwzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ILE A 442
LEU A 532
VAL A 712
PHE A 431
 None
 0.81A 4r38A-2vr5A:
undetectable		 4r38A-2vr5A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		4 ILE A 182
LEU A 149
LEU A 171
ILE A 161
 None
 0.73A 4r38A-2w3cA:
undetectable		 4r38A-2w3cA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		4 ILE A   5
LEU A  79
ILE A  76
PHE A  92
 TOP  A1160 (-4.2A)
NDP  A1159 ( 4.4A)
None
TOP  A1160 ( 3.9A)
 0.82A 4r38A-2w9sA:
undetectable		 4r38A-2w9sA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkp NPH1-1, RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 ASN A 449
LEU A 453
VAL A 463
PHE A 509
 FMN  A1725 (-3.0A)
FMN  A1725 (-4.2A)
FMN  A1725 (-4.6A)
None
 0.69A 4r38A-2wkpA:
17.7		 4r38A-2wkpA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT

(Rattus
norvegicus) 		PF01602
(Adaptin_N) 		4 ILE A 470
VAL A 461
ILE A 612
PHE A 605
 None
 0.79A 4r38A-2xa7A:
undetectable		 4r38A-2xa7A:
12.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z6c PHOTOTROPIN-1

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		4 ASN A 233
LEU A 237
ILE A 264
PHE A 293
 FMN  A 500 (-3.0A)
FMN  A 500 (-4.4A)
None
None
 0.60A 4r38A-2z6cA:
17.9		 4r38A-2z6cA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z6d PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		4 ASN A 169
LEU A 173
VAL A 183
PHE A 229
 FMN  A 500 (-3.0A)
FMN  A 500 ( 4.4A)
FMN  A 500 ( 4.4A)
FMN  A 500 ( 4.5A)
 0.68A 4r38A-2z6dA:
19.1		 4r38A-2z6dA:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0r SENSOR PROTEIN

(Thermotoga
maritima) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		4 THR A 735
ILE A 725
LEU A 716
PHE A 746
 None
 0.76A 4r38A-3a0rA:
9.2		 4r38A-3a0rA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a30 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF05257
(CHAP) 		4 THR A 183
ASN A 106
VAL A 143
ILE A 145
 None
 0.79A 4r38A-3a30A:
undetectable		 4r38A-3a30A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		4 ILE A  94
VAL A 266
LEU A 205
ILE A 262
 None
 0.78A 4r38A-3axiA:
undetectable		 4r38A-3axiA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx5 CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00355
(Rieske)
PF02921
(UCR_TM) 		4 ILE E 101
LEU E 200
VAL E 147
ILE E 202
 None
 0.78A 4r38A-3cx5E:
undetectable		 4r38A-3cx5E:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE

(Staphylococcus
aureus) 		PF13738
(Pyr_redox_3) 		4 ILE A  52
LEU A 184
LEU A 219
ILE A 229
 FAD  A 500 ( 4.0A)
None
None
None
 0.70A 4r38A-3d1cA:
undetectable		 4r38A-3d1cA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4r DOMAIN OF UNKNOWN
FUNCTION FROM THE
PFAM-B_34464 FAMILY

(Methanococcus
maripaludis) 		PF09891
(DUF2118) 		4 THR A  81
VAL A  18
LEU A  43
ILE A  20
 None
 0.81A 4r38A-3d4rA:
undetectable		 4r38A-3d4rA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjb CYTC3

(Streptomyces
sp.) 		PF05721
(PhyH) 		4 ILE A 281
LEU A  77
VAL A 289
ILE A  81
 None
 0.78A 4r38A-3gjbA:
undetectable		 4r38A-3gjbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrg UNCHARACTERIZED
PROTEIN BT_3980 WITH
ACTIN-LIKE ATPASE
FOLD

(Bacteroides
thetaiotaomicron) 		PF12864
(DUF3822) 		4 ILE A 152
VAL A 116
LEU A 111
ILE A 118
 None
 0.81A 4r38A-3hrgA:
undetectable		 4r38A-3hrgA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		4 LEU B  77
VAL B  67
ILE B  65
PHE B  87
 None
 0.80A 4r38A-3l4gB:
undetectable		 4r38A-3l4gB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyw YBBR FAMILY PROTEIN

(Desulfitobacterium
hafniense) 		no annotation 4 ILE A  74
VAL A  40
LEU A  43
ILE A  38
 None
 0.70A 4r38A-3lywA:
undetectable		 4r38A-3lywA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0z PUTATIVE ALDOLASE

(Klebsiella
pneumoniae) 		PF07071
(KDGP_aldolase) 		4 LEU A  17
VAL A 234
LEU A 237
ILE A 221
 None
 0.75A 4r38A-3m0zA:
undetectable		 4r38A-3m0zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 LEU A  69
VAL A 108
LEU A 111
ILE A 123
 None
 0.77A 4r38A-3mfdA:
undetectable		 4r38A-3mfdA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ILE A 476
VAL A 457
LEU A 460
PHE A 413
 None
 0.59A 4r38A-3mi6A:
undetectable		 4r38A-3mi6A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE

(Bacillus
anthracis) 		PF07071
(KDGP_aldolase) 		4 LEU A  18
VAL A 236
LEU A 239
ILE A 223
 None
 0.73A 4r38A-3muxA:
undetectable		 4r38A-3muxA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 THR A 124
ILE A 258
LEU A 250
ILE A 136
 None
 0.77A 4r38A-3nieA:
undetectable		 4r38A-3nieA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		4 ILE A 358
LEU A 147
ILE A 135
PHE A 121
 None
 0.77A 4r38A-3nzqA:
undetectable		 4r38A-3nzqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE

(Aliivibrio
fischeri) 		PF07071
(KDGP_aldolase) 		4 ILE A 213
VAL A 234
LEU A 237
ILE A 221
 None
 0.69A 4r38A-3nzrA:
undetectable		 4r38A-3nzrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzr 2-DEHYDRO-3-DEOXYPHO
SPHOGLUCONATE
ALDOLASE

(Aliivibrio
fischeri) 		PF07071
(KDGP_aldolase) 		4 LEU A  17
VAL A 234
LEU A 237
ILE A 221
 None
 0.81A 4r38A-3nzrA:
undetectable		 4r38A-3nzrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF

(Bacillus
subtilis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 THR A 198
LEU A  42
VAL A  31
LEU A  34
ILE A  11
 None
 1.09A 4r38A-3pdwA:
undetectable		 4r38A-3pdwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K

(Escherichia
coli) 		no annotation 4 ASN K  27
LEU K  32
VAL J  71
LEU J  74
 None
 0.80A 4r38A-3rkoK:
undetectable		 4r38A-3rkoK:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbg PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF12134
(PRP8_domainIV) 		4 ILE A2207
VAL A2171
LEU A2302
ILE A2169
 None
 0.80A 4r38A-3sbgA:
undetectable		 4r38A-3sbgA:
15.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t50 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE

(Brucella
melitensis) 		PF13426
(PAS_9) 		5 ASN A  68
LEU A  72
VAL A  82
ILE A  99
PHE A 128
 FMN  A 200 (-3.1A)
FMN  A 200 (-4.3A)
FMN  A 200 (-4.3A)
FMN  A 200 ( 4.4A)
FMN  A 200 (-4.5A)
 0.72A 4r38A-3t50A:
20.3		 4r38A-3t50A:
34.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqq METHIONYL-TRNA
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 THR A 237
LEU A 280
VAL A 264
LEU A 263
 None
 0.79A 4r38A-3tqqA:
undetectable		 4r38A-3tqqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		4 ILE A 445
LEU A 436
VAL A 507
LEU A 485
 None
 0.82A 4r38A-3vsmA:
undetectable		 4r38A-3vsmA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zei O-ACETYLSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 ILE A 153
ASN A 147
LEU A  52
ILE A  67
 None
 0.65A 4r38A-3zeiA:
undetectable		 4r38A-3zeiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 ILE A 293
LEU A 313
LEU A 305
ILE A 357
 None
 0.80A 4r38A-4ddwA:
undetectable		 4r38A-4ddwA:
8.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ees PHOTOTROPIN-2

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		4 ASN A 425
LEU A 429
VAL A 439
PHE A 485
 FMN  A1001 (-3.0A)
FMN  A1001 (-4.2A)
FMN  A1001 (-4.5A)
FMN  A1001 (-4.6A)
 0.60A 4r38A-4eesA:
7.6		 4r38A-4eesA:
35.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp KINESIN-LIKE PROTEIN
KAR3

(Saccharomyces
cerevisiae) 		PF00225
(Kinesin) 		4 LEU A 711
VAL A 698
LEU A 391
ILE A 700
 None
 0.71A 4r38A-4etpA:
undetectable		 4r38A-4etpA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 ILE W 773
VAL W 993
LEU W 996
ILE W1073
 None
 0.78A 4r38A-4f5xW:
undetectable		 4r38A-4f5xW:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcu 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Acinetobacter
baumannii) 		PF02348
(CTP_transf_3) 		4 THR A  68
VAL A 190
LEU A 193
ILE A  94
 None
 0.70A 4r38A-4fcuA:
undetectable		 4r38A-4fcuA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 LEU A 395
VAL A 244
LEU A 255
ILE A 390
 None
 0.79A 4r38A-4flnA:
undetectable		 4r38A-4flnA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcz BLUE-LIGHT
PHOTORECEPTOR,
SENSOR PROTEIN FIXL

(Bacillus
subtilis;
Bradyrhizobium
diazoefficiens) 		PF00512
(HisKA)
PF02518
(HATPase_c)
PF13426
(PAS_9) 		4 ASN A  61
LEU A  65
VAL A  75
ILE A  92
 FMN  A 401 (-3.1A)
FMN  A 401 (-4.5A)
FMN  A 401 ( 4.6A)
FMN  A 401 ( 4.6A)
 0.30A 4r38A-4gczA:
18.3		 4r38A-4gczA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcz BLUE-LIGHT
PHOTORECEPTOR,
SENSOR PROTEIN FIXL

(Bacillus
subtilis;
Bradyrhizobium
diazoefficiens) 		PF00512
(HisKA)
PF02518
(HATPase_c)
PF13426
(PAS_9) 		4 ASN A  61
LEU A  65
VAL A  75
PHE A 119
 FMN  A 401 (-3.1A)
FMN  A 401 (-4.5A)
FMN  A 401 ( 4.6A)
FMN  A 401 (-4.7A)
 0.69A 4r38A-4gczA:
18.3		 4r38A-4gczA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 11
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 22

(Schizosaccharomyces
pombe) 		PF06179
(Med22)
no annotation 		4 ILE K  24
VAL V  67
LEU V  70
ILE V  28
 None
 0.68A 4r38A-4h63K:
undetectable		 4r38A-4h63K:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh8 BUTYROPHILIN
SUBFAMILY 1 MEMBER
A1

(Bos taurus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 ILE A 110
VAL A  83
LEU A  22
ILE A  85
 None
 0.77A 4r38A-4hh8A:
undetectable		 4r38A-4hh8A:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hhd PHOTOTROPIN-1

(Arabidopsis
thaliana) 		PF13426
(PAS_9) 		4 ASN A 511
LEU A 515
VAL A 525
PHE A 571
 FMN  A 701 (-2.9A)
FMN  A 701 (-4.4A)
FMN  A 701 (-4.9A)
FMN  A 701 (-4.9A)
 0.66A 4r38A-4hhdA:
19.1		 4r38A-4hhdA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj3 LOV PROTEIN

(Rhodobacter
sphaeroides) 		PF13426
(PAS_9) 		4 THR A  21
ASN A  54
LEU A  58
PHE A 114
 FMN  A 201 (-4.4A)
FMN  A 201 (-3.1A)
FMN  A 201 (-4.4A)
None
 0.31A 4r38A-4hj3A:
15.4		 4r38A-4hj3A:
31.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-RELATED
PROTEIN 7

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 VAL A   8
LEU A 104
ILE A  10
PHE A 128
 None
 0.65A 4r38A-4i6mA:
undetectable		 4r38A-4i6mA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irv CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN

(Helicobacter
pylori) 		no annotation 4 VAL A  37
LEU A 165
ILE A 143
PHE A 117
 None
 0.74A 4r38A-4irvA:
undetectable		 4r38A-4irvA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isa UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Escherichia
coli) 		PF03331
(LpxC) 		4 ILE A 244
ASN A 253
ILE A 120
PHE A 182
 None
FMT  A 420 (-3.7A)
None
None
 0.78A 4r38A-4isaA:
undetectable		 4r38A-4isaA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		8 THR A  21
ILE A  25
ASN A  54
LEU A  58
VAL A  68
LEU A  71
ILE A  85
PHE A 114
 RBF  A 402 (-3.4A)
None
RBF  A 402 (-2.9A)
RBF  A 402 (-4.2A)
RBF  A 402 (-3.5A)
RBF  A 402 (-3.6A)
RBF  A 402 (-4.0A)
RBF  A 402 ( 4.3A)
 0.32A 4r38A-4r3aA:
4.2		 4r38A-4r3aA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ILE A  14
LEU A  27
VAL A  91
LEU A  86
 None
 0.79A 4r38A-4rncA:
undetectable		 4r38A-4rncA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tv4 UNCHARACTERIZED
PROTEIN

(Burkholderia
pseudomallei) 		PF05638
(T6SS_HCP) 		4 THR A 107
ILE A   9
VAL A 132
ILE A 155
 None
 0.80A 4r38A-4tv4A:
undetectable		 4r38A-4tv4A:
24.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY

(Trichoderma
reesei) 		PF13426
(PAS_9) 		5 THR A 101
ASN A 134
LEU A 138
VAL A 154
ILE A 171
 FMN  A5201 (-3.4A)
FMN  A5201 (-2.5A)
FMN  A5201 (-3.7A)
FMN  A5201 (-3.6A)
FMN  A5201 ( 4.4A)
 0.57A 4r38A-4wujA:
15.4		 4r38A-4wujA:
33.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wuj GLYCOSIDE HYDROLASE
FAMILY 15, CELLULOSE
SIGNALING ASSOCIATED
PROTEIN ENVOY

(Trichoderma
reesei) 		PF13426
(PAS_9) 		5 THR A 101
ILE A 105
ASN A 134
LEU A 138
VAL A 154
 FMN  A5201 (-3.4A)
None
FMN  A5201 (-2.5A)
FMN  A5201 (-3.7A)
FMN  A5201 (-3.6A)
 0.67A 4r38A-4wujA:
15.4		 4r38A-4wujA:
33.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		4 ILE A 270
LEU A 260
LEU A 368
ILE A 359
 None
 0.79A 4r38A-4x9eA:
undetectable		 4r38A-4x9eA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgc KELCH PROTEIN

(Plasmodium
falciparum) 		PF01344
(Kelch_1)
PF02214
(BTB_2)
PF13418
(Kelch_4) 		4 ILE A 723
ASN A 490
LEU A 440
ILE A 416
 None
 0.68A 4r38A-4zgcA:
undetectable		 4r38A-4zgcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2

(Legionella
pneumophila) 		PF00905
(Transpeptidase) 		4 ILE A 402
ASN A 504
LEU A 494
VAL A 468
 None
 0.62A 4r38A-4ztkA:
undetectable		 4r38A-4ztkA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxg GLUTATHIONE
S-TRANSFERASE

(Plasmodium
falciparum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ASN A 190
VAL A 103
ILE A  99
PHE A 183
 None
 0.82A 4r38A-4zxgA:
undetectable		 4r38A-4zxgA:
19.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a8b PTAUREO1A LOV2
DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		4 ASN A 286
LEU A 290
VAL A 300
PHE A 346
 FMN  A 500 (-3.2A)
FMN  A 500 (-4.0A)
None
FMN  A 500 (-4.8A)
 0.80A 4r38A-5a8bA:
17.8		 4r38A-5a8bA:
34.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 NEQ263

(Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab) 		4 ILE B 162
LEU B 222
LEU B 207
ILE B 274
 None
 0.68A 4r38A-5bn4B:
undetectable		 4r38A-5bn4B:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo0 HISTONE CHAPERONE
ASF1B

(Homo sapiens) 		PF04729
(ASF1_hist_chap) 		4 THR D 147
ILE D 151
ILE D  43
PHE D 106
 None
 0.80A 4r38A-5bo0D:
undetectable		 4r38A-5bo0D:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce0 NATIVE CONSERPIN
WITH Z-VARIANT
(E342K)

(synthetic
construct) 		PF00079
(Serpin) 		4 ILE A 129
LEU A  97
LEU A  91
ILE A 293
 None
 0.73A 4r38A-5ce0A:
undetectable		 4r38A-5ce0A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw6 DRBRCC36

(Danio rerio) 		PF01398
(JAB) 		4 ILE A 161
LEU A  31
VAL A  15
ILE A  49
 None
 0.80A 4r38A-5cw6A:
undetectable		 4r38A-5cw6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cze PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		4 LEU B  71
VAL B  40
LEU B  43
ILE B  62
 None
 0.76A 4r38A-5czeB:
undetectable		 4r38A-5czeB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czf PLASMID
STABILIZATION
PROTEIN PARE

(Escherichia
coli) 		PF05016
(ParE_toxin) 		4 LEU C  71
VAL C  40
LEU C  43
ILE C  62
 None
 0.78A 4r38A-5czfC:
undetectable		 4r38A-5czfC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 ILE A 577
LEU A 561
VAL A 547
LEU A 551
 None
 0.80A 4r38A-5d39A:
undetectable		 4r38A-5d39A:
14.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dkk LOV DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		4 ASN A 286
LEU A 290
VAL A 300
PHE A 346
 FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-4.4A)
FMN  A 401 (-4.8A)
 0.79A 4r38A-5dkkA:
17.7		 4r38A-5dkkA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erp DESMOCOLLIN-2

(Homo sapiens) 		PF00028
(Cadherin) 		4 ILE A 448
VAL A 513
LEU A 529
ILE A 515
 None
 0.74A 4r38A-5erpA:
undetectable		 4r38A-5erpA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 ASN A  96
LEU A 100
VAL A 110
PHE A 156
 FMN  A 402 (-3.2A)
FMN  A 402 (-4.1A)
FMN  A 402 (-4.5A)
FMN  A 402 (-4.9A)
 0.62A 4r38A-5hzhA:
17.5		 4r38A-5hzhA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		4 ASN B1354
LEU B1358
VAL B1368
PHE B1414
 FMN  B1801 (-3.0A)
FMN  B1801 (-4.2A)
FMN  B1801 (-4.5A)
FMN  B1801 (-4.8A)
 0.69A 4r38A-5hzkB:
17.9		 4r38A-5hzkB:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irp ALANINE RACEMASE 2

(Bacillus
subtilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 228
VAL A  12
LEU A 251
ILE A  10
 UAH  A 402 (-3.7A)
None
None
None
 0.74A 4r38A-5irpA:
undetectable		 4r38A-5irpA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		4 ILE A 269
LEU A 316
ILE A 151
PHE A 273
 None
 0.67A 4r38A-5jjtA:
undetectable		 4r38A-5jjtA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ket ALDO-KETO REDUCTASE
1

(Coptotermes
gestroi) 		PF00248
(Aldo_ket_red) 		4 THR A  61
ILE A  78
LEU A  21
ILE A 283
 None
 0.72A 4r38A-5ketA:
undetectable		 4r38A-5ketA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		4 ILE A 302
LEU A 313
ILE A 329
PHE A 458
 None
 0.64A 4r38A-5mjuA:
undetectable		 4r38A-5mjuA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL

(Homo sapiens) 		PF00300
(His_Phos_1) 		4 THR A 131
ILE A 286
LEU A 254
ILE A 234
 None
 0.79A 4r38A-5mufA:
undetectable		 4r38A-5mufA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 10
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomyces
pombe) 		PF08638
(Med14)
PF09748
(Med10) 		4 ASN A  43
VAL B  32
LEU B  35
ILE B  44
 None
 0.57A 4r38A-5n9jA:
undetectable		 4r38A-5n9jA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 THR T1271
ILE T1292
LEU T1241
ILE T1216
 None
 0.74A 4r38A-5ojsT:
undetectable		 4r38A-5ojsT:
3.40