SIMILAR PATTERNS OF AMINO ACIDS FOR 4R21_B_STRB601
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cyd | CARBONYL REDUCTASE (Mus musculus) |
PF13561(adh_short_C2) | 5 | ALA A 36ILE A 219VAL A 216GLY A 20ILE A 54 | None | 1.00A | 4r21B-1cydA:0.0 | 4r21B-1cydA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dm3 | BIOSYNTHETICTHIOLASE ACETYLATEDAT CYS89 (Zoogloearamigera) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA A 256VAL A 385GLY A 92ALA A 355ILE A 7 | None | 1.10A | 4r21B-1dm3A:undetectable | 4r21B-1dm3A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ILE A 84VAL A 82GLY A 27ALA A 28ILE A 47 | A79 A 800 (-3.6A)A79 A 800 (-4.5A)A79 A 800 (-3.0A)A79 A 800 (-3.2A)A79 A 800 ( 3.4A) | 1.07A | 4r21B-1hvcA:undetectable | 4r21B-1hvcA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ILE A 84VAL A 82GLY A 27ALA A 28ILE A 47 | A79 A 800 (-3.8A)A79 A 800 (-4.5A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 ( 3.2A) | 1.05A | 4r21B-1hvcA:undetectable | 4r21B-1hvcA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l7p | PHOSPHOSERINEPHOSPHATASE (Methanocaldococcusjannaschii) |
PF12710(HAD) | 5 | ALA A 105GLY A 100ALA A 120ILE A 104VAL A 134 | NoneSEP A 770 (-3.7A)NoneNoneNone | 1.03A | 4r21B-1l7pA:undetectable | 4r21B-1l7pA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obh | LEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF13603(tRNA-synt_1_2)PF14795(Leucyl-specific) | 5 | ALA A 311VAL A 305GLY A 308ALA A 309ILE A 243 | None | 1.06A | 4r21B-1obhA:2.6 | 4r21B-1obhA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pq5 | TRYPSIN (Fusariumoxysporum) |
PF00089(Trypsin) | 6 | ILE A 30VAL A 31GLY A 197ALA A 209ILE A 235VAL A 51 | None | 1.31A | 4r21B-1pq5A:undetectable | 4r21B-1pq5A:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqj | OLIGOXYLOGLUCANREDUCING-END-SPECIFIC CELLOBIOHYDROLASE (Geotrichum sp.M128) |
PF15899(BNR_6) | 5 | ALA A 383ILE A 11GLY A 14ALA A 416VAL A 367 | None | 1.08A | 4r21B-1sqjA:undetectable | 4r21B-1sqjA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlt | PUTATIVEOXIDOREDUCTASE(VIRULENCE FACTORMVIM HOMOLOG) (Escherichiacoli) |
PF01408(GFO_IDH_MocA) | 5 | ALA A 36ILE A 16GLY A 14SER A 50ILE A 53 | None | 1.10A | 4r21B-1tltA:0.0 | 4r21B-1tltA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ud3 | AMYLASE (Bacillus sp.KSM-K38) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ALA A 137ILE A 174VAL A 120GLY A 162THR A 180 | None | 0.96A | 4r21B-1ud3A:undetectable | 4r21B-1ud3A:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vme | FLAVOPROTEIN (Thermotogamaritima) |
PF00258(Flavodoxin_1) | 5 | ALA A 274ILE A 259GLY A 314ILE A 390VAL A 343 | None | 0.99A | 4r21B-1vmeA:undetectable | 4r21B-1vmeA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xw8 | UPF0271 PROTEIN YBGL (Escherichiacoli) |
PF03746(LamB_YcsF) | 5 | ALA A 93VAL A 127GLY A 87ILE A 54VAL A 103 | None | 1.07A | 4r21B-1xw8A:undetectable | 4r21B-1xw8A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ysj | PROTEIN YXEP (Bacillussubtilis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | VAL A 363GLY A 312ALA A 309THR A 315ILE A 374 | None | 0.99A | 4r21B-1ysjA:undetectable | 4r21B-1ysjA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eis | HYPOTHETICAL PROTEINTTHB207 (Thermusthermophilus) |
PF03061(4HBT) | 5 | ILE A 65VAL A 66GLY A 63THR A 15VAL A 60 | None | 1.06A | 4r21B-2eisA:undetectable | 4r21B-2eisA:13.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gks | BIFUNCTIONAL SAT/APSKINASE (Aquifexaeolicus) |
PF01583(APS_kinase)PF01747(ATP-sulfurylase)PF14306(PUA_2) | 5 | ILE A 430GLY A 434ALA A 437ILE A 448VAL A 411 | None | 1.10A | 4r21B-2gksA:undetectable | 4r21B-2gksA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gn1 | THREONINEDEHYDRATASECATABOLIC (Salmonellaenterica) |
PF00291(PALP) | 5 | ILE A 250VAL A 251GLY A 191ILE A 203VAL A 255 | None | 1.07A | 4r21B-2gn1A:undetectable | 4r21B-2gn1A:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h6e | D-ARABINOSE1-DEHYDROGENASE (Sulfolobussolfataricus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 158ILE A 312GLY A 152ILE A 243VAL A 184 | None | 1.01A | 4r21B-2h6eA:undetectable | 4r21B-2h6eA:22.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hi4 | CYTOCHROME P450 1A2 (Homo sapiens) |
PF00067(p450) | 5 | GLY A 316ALA A 317THR A 321ILE A 386VAL A 227 | BHF A 800 (-3.8A)HEM A 900 ( 3.5A)HEM A 900 ( 3.1A)HEM A 900 (-4.0A)None | 1.01A | 4r21B-2hi4A:40.9 | 4r21B-2hi4A:33.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjd | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE EPSILON (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ALA A 498GLY A 635ALA A 634ILE A 487VAL A 662 | None | 1.04A | 4r21B-2jjdA:2.2 | 4r21B-2jjdA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nq2 | HYPOTHETICAL ABCTRANSPORTER PERMEASEPROTEIN HI1471 (Haemophilusinfluenzae) |
PF01032(FecCD) | 5 | ILE A 260GLY A 73ALA A 291ILE A 66VAL A 297 | None | 1.09A | 4r21B-2nq2A:undetectable | 4r21B-2nq2A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nr4 | CONSERVEDHYPOTHETICAL PROTEIN (Methanosarcinamazei) |
PF04289(DUF447) | 5 | VAL A 102GLY A 143ALA A 117ILE A 32VAL A 111 | None | 0.94A | 4r21B-2nr4A:undetectable | 4r21B-2nr4A:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nx8 | TRNA-SPECIFICADENOSINE DEAMINASE (Streptococcuspyogenes) |
PF14437(MafB19-deam) | 5 | ILE A 111VAL A 110GLY A 113ALA A 114SER A 124 | None | 1.01A | 4r21B-2nx8A:undetectable | 4r21B-2nx8A:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzt | HEXOKINASE-2 (Homo sapiens) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | VAL A 659GLY A 900ALA A 902THR A 905VAL A 655 | None | 1.04A | 4r21B-2nztA:undetectable | 4r21B-2nztA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pk0 | SERINE/THREONINEPROTEIN PHOSPHATASESTP1 (Streptococcusagalactiae) |
PF13672(PP2C_2) | 5 | ILE A 3THR A 234SER A 119ILE A 101VAL A 189 | None | 1.09A | 4r21B-2pk0A:undetectable | 4r21B-2pk0A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtb | FATTY ACIDMULTIFUNCTIONALPROTEIN (ATMFP2) (Arabidopsisthaliana) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ILE A 647VAL A 490GLY A 495SER A 425VAL A 463 | None | 1.03A | 4r21B-2wtbA:undetectable | 4r21B-2wtbA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wxu | PHOSPHOLIPASE C (Clostridiumperfringens) |
PF00882(Zn_dep_PLPC)PF01477(PLAT) | 5 | ALA A 193ILE A 14VAL A 15GLY A 129SER A 102 | None | 0.96A | 4r21B-2wxuA:1.9 | 4r21B-2wxuA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zu0 | PROTEIN SUFD (Escherichiacoli) |
PF01458(UPF0051) | 5 | ALA A 169ILE A 69GLY A 67ALA A 66VAL A 94 | None | 0.89A | 4r21B-2zu0A:undetectable | 4r21B-2zu0A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3w | L-XYLULOSE REDUCTASE (Homo sapiens) |
PF13561(adh_short_C2) | 5 | ALA B 36ILE B 219VAL B 216GLY B 20ILE B 54 | None | 0.97A | 4r21B-3d3wB:undetectable | 4r21B-3d3wB:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6n | ASPARTATECARBAMOYLTRANSFERASE (Aquifexaeolicus) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | VAL B 160GLY B 120ALA B 119THR B 48ILE B 285 | NoneNoneNoneFLC B 292 (-4.1A)None | 0.97A | 4r21B-3d6nB:undetectable | 4r21B-3d6nB:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8r | THIOREDOXINREDUCTASE (TRXB-3) (Sulfolobussolfataricus) |
PF07992(Pyr_redox_2) | 5 | ALA A 30VAL A 123GLY A 286ALA A 285ILE A 20 | NoneNoneNAP A4005 (-3.3A)NoneNone | 1.04A | 4r21B-3f8rA:undetectable | 4r21B-3f8rA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpz | THIAZOLEBIOSYNTHETIC ENZYME (Saccharomycescerevisiae) |
PF01946(Thi4) | 5 | GLY A 307ALA A 308SER A 277ILE A 275VAL A 314 | None | 1.05A | 4r21B-3fpzA:undetectable | 4r21B-3fpzA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g05 | TRNA URIDINE5-CARBOXYMETHYLAMINOMETHYL MODIFICATIONENZYME MNMG (Escherichiacoli) |
PF01134(GIDA)PF13932(GIDA_assoc) | 5 | ALA A 21GLY A 369ALA A 368ILE A 11VAL A 155 | NoneSO4 A 551 ( 3.7A)NoneNoneSO4 A 551 ( 4.9A) | 0.76A | 4r21B-3g05A:undetectable | 4r21B-3g05A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hfw | PROTEINADP-RIBOSYLARGININEHYDROLASE (Homo sapiens) |
PF03747(ADP_ribosyl_GH) | 5 | VAL A 183GLY A 139SER A 11ILE A 309VAL A 316 | None | 0.94A | 4r21B-3hfwA:undetectable | 4r21B-3hfwA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8b | XYLULOSE KINASE (Bifidobacteriumadolescentis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ALA A 327GLY A 311ALA A 312SER A 419ILE A 417 | None | 1.09A | 4r21B-3i8bA:undetectable | 4r21B-3i8bA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ius | UNCHARACTERIZEDCONSERVED PROTEIN (Ruegeriapomeroyi) |
no annotation | 5 | ILE A 185VAL A 182SER A 44ILE A 28VAL A 16 | NoneNoneNoneNoneEDO A 286 (-3.7A) | 1.05A | 4r21B-3iusA:undetectable | 4r21B-3iusA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j09 | COPPER-EXPORTINGP-TYPE ATPASE A (Archaeoglobusfulgidus) |
PF00122(E1-E2_ATPase)PF00403(HMA)PF00702(Hydrolase) | 5 | ALA A 169ILE A 343VAL A 339GLY A 109ALA A 108 | None | 0.96A | 4r21B-3j09A:undetectable | 4r21B-3j09A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpw | ETHANOLAMINEUTILIZATION PROTEINEUTM (Escherichiacoli) |
no annotation | 5 | ALA G 26ILE G 7VAL G 72GLY G 59ALA G 58 | None | 1.02A | 4r21B-3mpwG:undetectable | 4r21B-3mpwG:13.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3omx | CG14216 (Drosophilamelanogaster) |
PF04722(Ssu72) | 5 | VAL A 140GLY A 152ALA A 153THR A 157VAL A 110 | None | 0.99A | 4r21B-3omxA:undetectable | 4r21B-3omxA:15.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pm0 | CYTOCHROME P450 1B1 (Homo sapiens) |
PF00067(p450) | 5 | ALA A 133GLY A 329ALA A 330THR A 334ILE A 399 | HEM A 900 (-3.3A)BHF A 800 ( 4.0A)HEM A 900 ( 3.4A)HEM A 900 ( 3.2A)HEM A 900 (-4.0A) | 0.50A | 4r21B-3pm0A:41.6 | 4r21B-3pm0A:34.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r0o | CARNITINYL-COADEHYDRATASE (Mycobacteriumavium) |
PF00378(ECH_1) | 5 | ALA A 108ILE A 205ALA A 198ILE A 61VAL A 21 | None | 1.10A | 4r21B-3r0oA:undetectable | 4r21B-3r0oA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sze | SERINE PROTEASE ESPP (Escherichiacoli) |
PF02395(Peptidase_S6) | 5 | VAL A 166GLY A 171ALA A 172THR A 115ILE A 306 | None | 1.00A | 4r21B-3szeA:undetectable | 4r21B-3szeA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3umm | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE (Salmonellaenterica) |
PF02769(AIRS_C)PF13507(GATase_5) | 5 | ILE A 655GLY A 372ALA A 309ILE A 316VAL A 333 | NoneNoneNoneNoneADP A2005 ( 4.2A) | 0.98A | 4r21B-3ummA:undetectable | 4r21B-3ummA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vtz | GLUCOSE1-DEHYDROGENASE (Thermoplasmavolcanium) |
PF13561(adh_short_C2) | 5 | ALA A 227ILE A 122VAL A 118ALA A 9ILE A 128 | None | 0.98A | 4r21B-3vtzA:undetectable | 4r21B-3vtzA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ej0 | ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE (Burkholderiathailandensis) |
PF01370(Epimerase) | 5 | ALA A 30ILE A 12GLY A 10ALA A 9ILE A 48 | NoneNAP A 401 (-3.9A)NAP A 401 (-3.3A)NoneNone | 0.98A | 4r21B-4ej0A:undetectable | 4r21B-4ej0A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f9o | HEXOKINASE-1 (Homo sapiens) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 5 | VAL A 659GLY A 900ALA A 902THR A 905VAL A 655 | None | 1.05A | 4r21B-4f9oA:undetectable | 4r21B-4f9oA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha6 | PYRIDOXINE 4-OXIDASE (Mesorhizobiumloti) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | VAL A 491GLY A 268ALA A 269THR A 466ILE A 505 | NoneFAD A 601 (-3.6A)NoneNoneFAD A 601 (-4.4A) | 1.09A | 4r21B-4ha6A:undetectable | 4r21B-4ha6A:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6n | UBIQUITINCARBOXYL-HYDROLASE (Trichinellaspiralis) |
PF01088(Peptidase_C12) | 5 | ALA A 198ILE A 222VAL A 30GLY A 48ILE A 202 | None | 1.04A | 4r21B-4i6nA:undetectable | 4r21B-4i6nA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ig7 | UBIQUITIN C-TERMINALHYDROLASE 37 (Trichinellaspiralis) |
PF01088(Peptidase_C12) | 5 | ALA A 198ILE A 222VAL A 30GLY A 48ILE A 202 | None | 1.05A | 4r21B-4ig7A:undetectable | 4r21B-4ig7A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igd | MANNAN-BINDINGLECTIN SERINEPROTEASE 1 (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | ALA A 643ILE A 463GLY A 648ILE A 606VAL A 651 | None | 0.84A | 4r21B-4igdA:undetectable | 4r21B-4igdA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ivn | TRANSCRIPTIONALREGULATOR (Vibriovulnificus) |
PF01380(SIS)PF01418(HTH_6) | 5 | ILE A 140VAL A 141GLY A 235ALA A 236SER A 104 | NoneNoneBMX A1000 ( 4.7A)NoneNone | 0.92A | 4r21B-4ivnA:undetectable | 4r21B-4ivnA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jig | DEHYDROGENASE (Burkholderiacenocepacia) |
PF13561(adh_short_C2) | 5 | ALA A 45VAL A 66GLY A 14ALA A 15ILE A 61 | NoneNoneACT A 301 ( 4.8A)NoneNone | 0.99A | 4r21B-4jigA:undetectable | 4r21B-4jigA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlv | C-TERMINAL FRAGMENTOF MEMBRANE PROTEINCAPA1, PUTATIVEUNCHARACTERIZEDPROTEIN CAPB1 (Staphylococcusaureus) |
PF13614(AAA_31) | 5 | ALA A1196ILE A 200THR A1047SER A1177VAL A1208 | None | 1.08A | 4r21B-4jlvA:undetectable | 4r21B-4jlvA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jnq | THIOREDOXINREDUCTASE (Brucellamelitensis) |
PF07992(Pyr_redox_2) | 5 | ILE A 208GLY A 223ALA A 238SER A 171VAL A 150 | None | 1.06A | 4r21B-4jnqA:undetectable | 4r21B-4jnqA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 6 | ALA D 191VAL D 240GLY D 12ALA D 81ILE D 143VAL D 187 | None | 1.33A | 4r21B-4jrmD:undetectable | 4r21B-4jrmD:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k2x | POLYKETIDEOXYGENASE/HYDROXYLASE (Streptomycesrimosus) |
PF01494(FAD_binding_3) | 5 | ALA A 275GLY A 287ALA A 289ILE A 167VAL A 152 | NoneFAD A 601 (-3.5A)NoneNoneNone | 1.08A | 4r21B-4k2xA:undetectable | 4r21B-4k2xA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k5r | OXYGENASE (Streptomycesargillaceus) |
PF01494(FAD_binding_3) | 5 | ALA A 279GLY A 291ALA A 293ILE A 178VAL A 163 | NoneFAD A 601 (-3.5A)NoneNoneNone | 1.06A | 4r21B-4k5rA:undetectable | 4r21B-4k5rA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lbw | ELONGATION FACTORTU-A (Thermusthermophilus) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | ALA A 123GLY A 15ALA A 102ILE A 120VAL A 105 | None | 1.06A | 4r21B-4lbwA:undetectable | 4r21B-4lbwA:21.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 5 | ALA A 113GLY A 301ALA A 302ILE A 371VAL A 483 | HEM A 600 ( 2.9A)3QZ A 601 ( 3.0A)3QZ A 601 (-2.9A)HEM A 600 (-3.8A)3QZ A 601 (-4.1A) | 0.97A | 4r21B-4nkyA:49.1 | 4r21B-4nkyA:44.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 6 | ALA A 113ILE A 205GLY A 301ALA A 302THR A 306ILE A 371 | HEM A 600 ( 2.9A)3QZ A 601 ( 3.4A)3QZ A 601 ( 3.0A)3QZ A 601 (-2.9A)HEM A 600 ( 3.2A)HEM A 600 (-3.8A) | 0.89A | 4r21B-4nkyA:49.1 | 4r21B-4nkyA:44.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 5 | ILE A 205GLY A 301ALA A 302THR A 306VAL A 482 | 3QZ A 601 ( 3.4A)3QZ A 601 ( 3.0A)3QZ A 601 (-2.9A)HEM A 600 ( 3.2A)3QZ A 601 (-4.1A) | 0.86A | 4r21B-4nkyA:49.1 | 4r21B-4nkyA:44.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oal | CYTOKININDEHYDROGENASE 4 (Zea mays) |
PF01565(FAD_binding_4)PF09265(Cytokin-bind) | 5 | ALA A 84VAL A 211GLY A 79ILE A 521VAL A 205 | None | 1.10A | 4r21B-4oalA:undetectable | 4r21B-4oalA:23.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r16 | 418AA LONGHYPOTHETICALUDP-N-ACETYL-D-MANNOSAMINURONIC ACIDDEHYDROGENASE (Pyrococcushorikoshii) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | ILE A 168GLY A 170ALA A 147THR A 125ILE A 80 | None | 0.96A | 4r21B-4r16A:undetectable | 4r21B-4r16A:22.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 7 | ALA A 126ILE A 218VAL A 219ALA A 313THR A 317SER A 378ILE A 382 | HEM A 600 (-3.6A)AER A 601 ( 4.3A)NoneHEM A 600 (-3.5A)HEM A 600 ( 3.3A)HEM A 600 ( 4.6A)HEM A 600 ( 4.1A) | 1.00A | 4r21B-4r1zA:49.1 | 4r21B-4r1zA:46.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 7 | ALA A 126ILE A 218VAL A 219ALA A 313THR A 317SER A 378VAL A 493 | HEM A 600 (-3.6A)AER A 601 ( 4.3A)NoneHEM A 600 (-3.5A)HEM A 600 ( 3.3A)HEM A 600 ( 4.6A)None | 1.09A | 4r21B-4r1zA:49.1 | 4r21B-4r1zA:46.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 6 | ALA A 126VAL A 219GLY A 312ALA A 313THR A 317ILE A 382 | HEM A 600 (-3.6A)NoneAER A 601 ( 3.7A)HEM A 600 (-3.5A)HEM A 600 ( 3.3A)HEM A 600 ( 4.1A) | 1.16A | 4r21B-4r1zA:49.1 | 4r21B-4r1zA:46.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 6 | ALA A 126VAL A 219GLY A 312ALA A 313THR A 317VAL A 493 | HEM A 600 (-3.6A)NoneAER A 601 ( 3.7A)HEM A 600 (-3.5A)HEM A 600 ( 3.3A)None | 1.21A | 4r21B-4r1zA:49.1 | 4r21B-4r1zA:46.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 5 | ALA A 120GLY A 301ALA A 302ILE A 371VAL A 481 | AER A 602 (-3.7A)AER A 602 ( 3.8A)HEM A 601 (-3.4A)HEM A 601 ( 4.9A)None | 0.99A | 4r21B-4r20A:59.5 | 4r21B-4r20A:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 9 | ALA A 120ILE A 212VAL A 213GLY A 301ALA A 302THR A 306SER A 367ILE A 371VAL A 480 | AER A 602 (-3.7A)AER A 602 (-3.2A)NoneAER A 602 ( 3.8A)HEM A 601 (-3.4A)HEM A 601 ( 3.3A)AER A 602 (-3.5A)HEM A 601 ( 4.9A)AER A 602 ( 4.9A) | 0.76A | 4r21B-4r20A:59.5 | 4r21B-4r20A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s38 | 4-HYDROXY-3-METHYLBUT-2-EN-1-YLDIPHOSPHATE SYNTHASE (Thermusthermophilus) |
PF04551(GcpE) | 5 | ALA A 369VAL A 294GLY A 357ILE A 386VAL A 315 | NoneMES A 902 (-4.2A)NoneNoneNone | 1.06A | 4r21B-4s38A:undetectable | 4r21B-4s38A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u9i | PERIPLASMIC [NIFE]HYDROGENASE LARGESUBUNITPERIPLASMIC [NIFE]HYDROGENASE SMALLSUBUNIT (Desulfovibriovulgaris) |
PF00374(NiFeSe_Hases)PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | ALA L 249GLY S 246ALA S 245ILE L 111VAL L 240 | None | 0.83A | 4r21B-4u9iL:undetectable | 4r21B-4u9iL:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoz | BETA-GALACTOSIDASE (Bifidobacteriumanimalis) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 6 | ALA A 605ILE A 524VAL A 527THR A 571ILE A 604VAL A 601 | None | 1.47A | 4r21B-4uozA:undetectable | 4r21B-4uozA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wvm | STONUSTOXIN SUBUNITALPHA (Synanceiahorrida) |
PF00622(SPRY)PF13765(PRY) | 5 | ALA A 481VAL A 452GLY A 489ILE A 298VAL A 370 | None | 1.06A | 4r21B-4wvmA:3.4 | 4r21B-4wvmA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yhx | RIBOSOMAL PROTEIN3/HOMINGENDONUCLEASE-LIKEFUSION PROTEIN (Grosmanniapenicillata) |
PF00961(LAGLIDADG_1) | 5 | ALA A 16VAL A 86THR A 60ILE A 44VAL A 63 | None | 1.10A | 4r21B-4yhxA:undetectable | 4r21B-4yhxA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynn | PROTEASE DO (Legionellapneumophila) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | ILE A 21GLY A 192ALA A 190SER A 62ILE A 83 | None | 1.05A | 4r21B-4ynnA:undetectable | 4r21B-4ynnA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z42 | UREASE SUBUNIT ALPHA (Yersiniaenterocolitica) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | ILE C 91VAL C 71GLY C 98THR C 112ILE C 85 | None | 1.03A | 4r21B-4z42C:undetectable | 4r21B-4z42C:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5anb | EUKARYOTICTRANSLATIONINITIATION FACTOR 6 (Dictyosteliumdiscoideum) |
PF01912(eIF-6) | 5 | VAL I 92GLY I 65ALA I 64ILE I 97VAL I 94 | None | 1.09A | 4r21B-5anbI:undetectable | 4r21B-5anbI:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bqk | ICP27 (Humanalphaherpesvirus1) |
PF05459(Herpes_UL69) | 5 | ALA A 426ILE A 495VAL A 496THR A 478ILE A 425 | None | 1.10A | 4r21B-5bqkA:undetectable | 4r21B-5bqkA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bsh | PYRROLINE-5-CARBOXYLATE REDUCTASE (Medicagotruncatula) |
PF03807(F420_oxidored)PF14748(P5CR_dimer) | 5 | ALA A 26ILE A 44GLY A 17SER A 72ILE A 40 | None | 1.08A | 4r21B-5bshA:2.5 | 4r21B-5bshA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ds0 | PEPTIDASE M42 (Thaumarchaeotaarchaeon SCGCAB-539-E09) |
PF05343(Peptidase_M42) | 5 | ALA A 221GLY A 65ALA A 64SER A 314VAL A 316 | None | 1.07A | 4r21B-5ds0A:undetectable | 4r21B-5ds0A:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f38 | ACETYL-COAACETYLTRANSFERASE (Escherichiacoli) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | ALA B 112ILE B 386GLY B 355ALA B 356ILE B 259 | NoneMLY B 86 ( 4.8A)CSX B 88 ( 4.3A)NoneNone | 1.04A | 4r21B-5f38B:undetectable | 4r21B-5f38B:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g0a | TRANSAMINASE (Bacillusmegaterium) |
PF00202(Aminotran_3) | 5 | GLY A 154ALA A 155THR A 159ILE A 267VAL A 189 | None | 1.00A | 4r21B-5g0aA:undetectable | 4r21B-5g0aA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gk2 | KETOSYNTHASE STLD (Photorhabduslaumondii) |
PF08541(ACP_syn_III_C) | 5 | ALA A 91ILE A 215ALA A 148THR A 145ILE A 120 | None | 1.08A | 4r21B-5gk2A:undetectable | 4r21B-5gk2A:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gq0 | EPITHIOSPECIFIERPROTEIN (Arabidopsisthaliana) |
no annotation | 5 | ILE B 255VAL B 249GLY B 316ALA B 309ILE B 28 | None | 1.10A | 4r21B-5gq0B:undetectable | 4r21B-5gq0B:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i20 | UNCHARACTERIZEDPROTEIN (Starkeyanovella) |
PF00892(EamA) | 5 | ALA A 246GLY A 277ALA A 278THR A 282ILE A 14 | NoneNoneNoneOLC A 302 ( 4.4A)None | 0.93A | 4r21B-5i20A:undetectable | 4r21B-5i20A:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jk7 | URACIL-DNAGLYCOSYLASE (Homo sapiens) |
PF03167(UDG) | 5 | ILE D 141VAL D 140GLY D 143ALA D 205THR D 226 | None | 1.09A | 4r21B-5jk7D:undetectable | 4r21B-5jk7D:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jm7 | AEROBACTIN SYNTHASEIUCA (Klebsiellapneumoniae) |
PF04183(IucA_IucC)PF06276(FhuF) | 5 | VAL A 292GLY A 330ALA A 329ILE A 275VAL A 295 | None | 1.08A | 4r21B-5jm7A:undetectable | 4r21B-5jm7A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m41 | NIGRITOXINE (Vibrionigripulchritudo) |
no annotation | 5 | ALA A 255ILE A 438GLY A 359ILE A 247VAL A 328 | None | 1.00A | 4r21B-5m41A:undetectable | 4r21B-5m41A:9.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd1 | CAPSID PROTEIN (Rosellinianecatrixquadrivirus 1) |
no annotation | 5 | ALA B 439ILE B 487THR B 225ILE B 159VAL B 232 | None | 1.06A | 4r21B-5nd1B:undetectable | 4r21B-5nd1B:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t8d | I-ONUI_E-VHIVINT_V2 (syntheticconstruct) |
PF00961(LAGLIDADG_1) | 5 | ALA A 19VAL A 89THR A 63ILE A 47VAL A 66 | None | 1.07A | 4r21B-5t8dA:undetectable | 4r21B-5t8dA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w76 | ANCESTRAL ELOGATIONFACTOR N153 (syntheticconstruct) |
no annotation | 5 | ALA A 123GLY A 16ALA A 102ILE A 120VAL A 105 | None | 1.07A | 4r21B-5w76A:undetectable | 4r21B-5w76A:8.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7q | CONSENSUS ELONGATIONFACTOR (syntheticconstruct) |
no annotation | 5 | ALA A 123GLY A 16ALA A 102ILE A 120VAL A 105 | None | 1.01A | 4r21B-5w7qA:undetectable | 4r21B-5w7qA:9.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xdy | HEAT SHOCK PROTEINHTRA (Mycobacteriumtuberculosis) |
no annotation | 5 | ALA A 308ILE A 258GLY A 256SER A 245VAL A 286 | None | 1.06A | 4r21B-5xdyA:undetectable | 4r21B-5xdyA:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgv | PYRE3 (Streptomycesrugosporus) |
no annotation | 5 | ALA A 262GLY A 274ALA A 276ILE A 162VAL A 147 | NoneFAD A 501 (-3.5A)NoneNoneNone | 1.04A | 4r21B-5xgvA:undetectable | 4r21B-5xgvA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zya | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | ALA C 745ILE C 690VAL C 687ALA C 710VAL C 727 | None | 1.01A | 4r21B-5zyaC:undetectable | 4r21B-5zyaC:9.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b82 | CYTOCHROME P450,FAMILY 17, SUBFAMILYA, POLYPEPTIDE 1 (Danio rerio) |
no annotation | 6 | ALA A 126ILE A 218GLY A 312ALA A 313THR A 317SER A 378 | HEM A 601 (-3.8A)AER A 602 (-3.9A)AER A 602 ( 3.7A)HEM A 601 (-3.6A)HEM A 601 ( 3.7A)AER A 602 (-3.2A) | 1.15A | 4r21B-6b82A:46.9 | 4r21B-6b82A:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b82 | CYTOCHROME P450,FAMILY 17, SUBFAMILYA, POLYPEPTIDE 1 (Danio rerio) |
no annotation | 6 | ALA A 126ILE A 218GLY A 312THR A 317SER A 378ILE A 382 | HEM A 601 (-3.8A)AER A 602 (-3.9A)AER A 602 ( 3.7A)HEM A 601 ( 3.7A)AER A 602 (-3.2A)None | 1.08A | 4r21B-6b82A:46.9 | 4r21B-6b82A:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b82 | CYTOCHROME P450,FAMILY 17, SUBFAMILYA, POLYPEPTIDE 1 (Danio rerio) |
no annotation | 6 | ALA A 126ILE A 218VAL A 219GLY A 312ALA A 313THR A 317 | HEM A 601 (-3.8A)AER A 602 (-3.9A)AER A 602 (-4.8A)AER A 602 ( 3.7A)HEM A 601 (-3.6A)HEM A 601 ( 3.7A) | 1.19A | 4r21B-6b82A:46.9 | 4r21B-6b82A:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b82 | CYTOCHROME P450,FAMILY 17, SUBFAMILYA, POLYPEPTIDE 1 (Danio rerio) |
no annotation | 5 | ILE A 218VAL A 219ALA A 313THR A 317VAL A 493 | AER A 602 (-3.9A)AER A 602 (-4.8A)HEM A 601 (-3.6A)HEM A 601 ( 3.7A)AER A 602 ( 4.7A) | 0.81A | 4r21B-6b82A:46.9 | 4r21B-6b82A:9.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | ALA C 745ILE C 690VAL C 687ALA C 710VAL C 727 | None | 1.08A | 4r21B-6en4C:undetectable | 4r21B-6en4C:11.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gbh | HOPQ (Helicobacterpylori) |
no annotation | 5 | ALA C 227ILE C 347ALA C 90ILE C 165VAL C 380 | None | 0.92A | 4r21B-6gbhC:undetectable | 4r21B-6gbhC:9.28 |